CORONA Main Coronavirus thread
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Heliobas Disciple
TB Fanatic
I watched the whole thing and it was the most scientific, technical interview i've heard Geert give. It was way over my head, but the end result is he still expects the "geert variant" (my term) (as your twtitter link of that part of the video shows) and can't give a time for when he expects to see it, and he said there are things he didn't expect and still doesn't understand about the whole thing. (and personally I'm hoping that means maybe he'll be wrong - too many people I love are vaxxed and I pray he's wrong every day).
Syed did a fantastic job, he seems like a great, compassionate doctor so extra kudos to him for the interview.
I will say my newfound knowledge (previously discussed here) of Geert's history of working with failed mrna vaccines in his past made me appreciate more what he was saying. The subject was not raised though, I wish it had been.
And he said new news about the availability of the book in the USA should be forthcoming soon. If it's anything like that interview, which I suspect it will be since he said multiple times that he went into more detail in the book, I'll pass! It's geared for the scientific community, not laypeople like me.
Thanks again for the link.
HD
Heliobas Disciple
TB Fanatic
COVID is still out there. Here's what to do if you get it now
It's 2023 and you just tested positive for COVID-19. Now what? The latest CDC protocols, isolation recommendations, ways to treat it and ways to prevent long COVID.
COVID is still out there. Here's what to do if you get it now
Jessica Roy - LA Times
Fri, March 24, 2023, 8:00 AM EDT
The government is ready to declare COVID-19 over: The nationwide state of emergency is set to end on May 11. In California, the state of emergency concluded in February. Johns Hopkins University shut down its nationwide COVID-19 data tracking this month.
But COVID-19 isn't gone. Though cases and deaths are on a downswing, plenty of people are still testing positive, especially as mask usage dwindles and pandemic restrictions end. Hundreds of people still die of COVID worldwide every day, according to the World Health Organization.
"It's really hard to not catch Omicron," said Paula Cannon, a virology professor at the USC Keck School of Medicine. "It's so freaking infectious, even if you've been boosted and vaccinated."
After three years and what feels like a thousand public health proclamations about testing and isolating, you might find yourself falling down a frantic Google hole after that second line shows up on an at-home test.
Here are the latest protocols for what you should do if you test positive for COVID in 2023.
How long after exposure do you develop COVID symptoms?
If you've been exposed to COVID, symptoms of infection can show up two to 14 days later, according to a 2020 survey of reported cases. Most infected people began showing symptoms three to six days after exposure; the median length of time between exposure and infection was five days. Of course, you won't necessarily know if or when you've been exposed.
Back in 2020, one hallmark of COVID was a sudden loss of taste and smell. But now, "anything going on in your head, nose or throat, you should absolutely suspect COVID," Cannon said. Sniffles, fatigue, cough, sore throat, fever, stuffy nose, muscle aches — they could all point to COVID, though they could also be signs of any of the plethora of respiratory illnesses floating around in this tripledemic winter.
Loss of taste is a lot less prevalent now but could still be a symptom, said Muntu Davis, health officer for the L.A. County Department of Public Health. In a more severe case, he said, symptoms could include shortness of breath, racing heart, nausea, vomiting and diarrhea.
When should you take a COVID test?
If you've done something during which you could have been exposed to COVID — such as traveled by plane or gone maskless in a large crowd — it's a good idea to test after a few days even if you don't have any symptoms, Cannon said. Over Christmas, she traveled to England and celebrated her birthday at a large family gathering. After returning home, she took a test as a precaution. She got a positive result — her first time catching COVID in three years of the pandemic.
"I had absolutely no symptoms and would not have learned I had COVID apart from having taken the test," she said. "People should also be aware that no symptoms is also a symptom of COVID."
Home antigen tests are widely available and can reliably determine if you have a significant enough viral load to be contagious. You do not need to take a follow-up PCR test if you've had a positive result on a home test.
You aren't required to report your result to the county or anywhere else, Davis said, though he did recommend letting your healthcare provider know.
The new isolation guidelines for COVID
The most recent recommendation from the U.S. Centers for Disease Control and Prevention is to isolate for five full days after symptoms begin. That means the first day you start to feel sick is Day Zero; your five-day countdown begins the next day. If you tested positive but are asymptomatic, the recommendation is to isolate for five full days after the positive test.
Those first five days represent the period during which you are the most infectious, said Georges Benjamin, the executive director of the American Public Health Assn.
"Certainly the first five days, you should definitely isolate," he said.
But that's the minimum, not the maximum. Getting to Day Six doesn't mean you can abandon all precautions. That's the first day you can evaluate how you're feeling to determine if you need to continue isolation: Are your symptoms improving? Have you been fever-free for at least 24 hours without using an over-the-counter fever-reducing medicine (acetaminophen or ibuprofen)?
If you are feeling better and are fever-free without medication, you can end your isolation, Davis said. If not, you need to continue, for up to 10 days.
While you are isolating, you should stay home and limit contact with anyone who's not infected, both inside your home and out. If you need to leave your house for a necessary reason — for instance, to pick up a medication or grocery delivery from your lobby — Benjamin said you should wear a tight-fitting N95 mask.
How long do COVID symptoms last?
The length of your symptoms will depend on a lot of factors, including whether you're up to date on vaccinations and boosters and whether you take Paxlovid (more on that in a moment). Some people will feel better after a few days and some people will still have symptoms after 10 days, possibly even weeks later.
Beyond taking Paxlovid, there isn't much you can actively do to make COVID symptoms go away. Do what you'd normally do when you're sick: Rest; drink lots of fluids; eat healthy meals; take acetaminophen to control aches and fever. In other words, take good care of yourself.
If you start to experience severe symptoms, even if you're fully vaccinated and boosted, you should go to the hospital, Davis said.
"Definitely [go] if you're having a hard time breathing, catching your breath, if you’re really really really really super fatigued and not able to do much," he said. He also said chest pressure or pain, confusion, trouble waking up or staying awake, and bluish or pale gray lips and nails are signs you need to see a doctor right away.
Who should get Paxlovid, and how do you get it?
Paxlovid is an antiviral treatment for COVID-19. There is a broad evidence-based scientific consensus that using it reduces the risk of being hospitalized or dying. Paxlovid may also reduce the chance of developing long COVID in some patients, Benjamin said.
Paxlovid is a five-day course of medication taken twice daily. Treatment has to begin within five days of developing COVID symptoms. Paxlovid may have negative interactions with certain prescription drugs, including statins and some heart and blood pressure medications. Some people who take Paxlovid report noticing an unpleasant metallic taste in their mouths — so-called Paxlovid mouth — which typically goes away after you're done using the medication.
Right now, Paxlovid is prescribed in the U.S. only to people who have certain risk factors that increase the chances of a dangerous outcome from a COVID-19 infection. It's a wide range of conditions and behaviors, including being older than 50, being unvaccinated or not up to date on your booster shots, and health conditions including diabetes, heart conditions, a body mass index classified as obese, pregnancy or recent pregnancy, smoking, physical inactivity, and mental health conditions including depression.
That list of conditions continues to expand, Benjamin said, and even for young, healthy people, "some would say [Paxlovid is] unnecessary, but I would say call your physician and follow their advice."
If you don't have a regular physician, or if they can't see you quickly when you get sick, try a telehealth provider, Cannon said. She said she was on a video call with a "doc in a box" from a telehealth app within an hour of testing positive.
Cannon said she thinks restricting who qualifies for Paxlovid right now is a mistake and that the drug should be more widely available. Beyond the listed eligibility conditions for Paxlovid, she said, "being at risk can be a judgment call by your doctor. Especially if you don't feel good, if you believe that you respond badly to respiratory infections," it's worth talking to a medical professional and asking about a prescription.
What some people term a "Paxlovid rebound" — in which they have COVID, take Paxlovid, test negative, then test positive again days or weeks later — is really a COVID rebound, Cannon said. The treatment is effective enough that you reduce your viral load so that an infection doesn't show up on a test; then after treatment ends, your viral load increases again. That isn't Paxlovid's fault, or a sign it didn't work, she said: "It's a natural rhythm of the infection."
How long are you contagious with COVID?
Right now, Benjamin said, evidence suggests you are definitely contagious for that first five days after you start to develop symptoms or get a positive test result. In those first five days, it's important to stay home and isolate as much as possible.
Beyond that, you should assume you are still infectious as long as you are getting a positive result on a home test. (PCR tests are more sensitive than antigen tests, so a PCR test may return a positive result even after you test negative on a home test.) That's what Cannon did when she had asymptomatic COVID.
"I used the crude estimate of the little COVID test," Cannon said. "If there's enough virus in my nose to turn the test positive, then I know I've still got virus and I'm potentially infectious. Once that test goes negative, I would feel very comfortable saying somebody is not infectious."
If you've reached the five-day threshold and you're feeling better and are fever-free without medication, it's generally considered safe for you to go out. Benjamin said you are still theoretically infectious up to day 10, though much less so, so you should exercise caution around people who could become severely ill.
"If you're going around someone who is immunocompromised, if you're going to go see Grandma, I would still not do that within 10 days" of a positive test, he said.
Beyond that, he said, "you can assume you're not infectious. The risk is very low that you're infectious [at that point]. Nothing's 100%. But that's pretty good."
Is there any way to avoid or prevent long COVID?
Benjamin said the scientific world is only in the early stages of determining what constitutes long COVID, who's the most at risk, and looking into possible preventive measures.
A study recently published in JAMA Internal Medicine suggested an overall healthy lifestyle — adequate nutrition and sleep, regular exercise, moderate alcohol consumption — could lower women's risk of developing long COVID. Another study, published in Cell, identified four risk factors for long COVID, including Type 2 diabetes.
How long are you immune after recovering from COVID?
We don't have a solid answer to this question yet either. Davis, the L.A. County health officer, said the guidance used to be that you were considered immune and shouldn't have to test again within 90 days after you had an infection; now, he said, it's 30 days. But that's just a guideline, not a definitive scientific consensus.
A recent, widely reported meta-analysis published in the Lancet showed many people have antibodies in their blood 10 months after an infection. But the presence of antibodies doesn't mean you're guaranteed to not develop a symptomatic infection — it means your odds are lower. And reinfection protection was shown to be "substantially lower" for omicron variants, which have been the dominant strains in the United States for over a year.
A CDC study of seroprevalence — testing for the presence of antibodies in people's blood — showed that as of May 2022, almost 95% of Americans had either had COVID, gotten vaccinated for COVID, or both. At this point, it's unlikely we will ever reach a point where herd immunity will wipe out COVID entirely. Some scientists are working on tests that look at T-cell immunity, instead of antibody levels, to assess whether someone is immune. For now, it's impossible to say how long you can stop worrying about getting COVID after recovering from it.
psychgirl
Has No Life - Lives on TB
Reminder for me to listen later.
I’m so behind! I just can’t seem to catch up these days.
Thank you!!
Zoner
Veteran Member
Thanks HD for your take. Geert said nature will be the only thing to end this pandemic. But I wonder if he believes this is a bio-weapon? That changes things because if it is, then this could simply be a fast/slow roll to the grave.
I also like Dr. Syed. He has helped many many people with long covid and those with Vax injuries. He's the best.
Heliobas Disciple
TB Fanatic
This is the first interview I heard him mention side effects of the vaxx. He only mentioned it in passing, more than once. Never heard him even acknowledge that aspect of mrna before. But when he went over the very technical mechanisms of MRNA, and when he said the mrna vaxx recipients will get the worst effects of the 'geert variant', even more so than the DNA vaxxed, I suspect he was speaking with knowledge of all the studies he has done on MRNA in the past so that put more weight on his (confusing to me because they were so technical) statements.
have you listened to the whole thing? were you able to make any sense of it? It was very technical, I didn't have energy or the inclination to relisten a few times to understand the science (which I used to do so I do know his basic theories pretty well).. He's admitted he's changed some of his thinking, and he said it was a dynamic situation and he's always evalutating the new data so that leaves room in my mind for his horrific scenario to hopefully be wrong...
HD
have you listened to the whole thing? were you able to make any sense of it? It was very technical, I didn't have energy or the inclination to relisten a few times to understand the science (which I used to do so I do know his basic theories pretty well).. He's admitted he's changed some of his thinking, and he said it was a dynamic situation and he's always evalutating the new data so that leaves room in my mind for his horrific scenario to hopefully be wrong...
HD
psychgirl
Has No Life - Lives on TB
Yes he is!
He’s the doctor who came to our rescue last winter with DH Covid pneumonia!
I still get his email blogs and just love his caring style and attitude!
Zoner
Veteran Member
I need to listen to it again with the goal of taking notes. I try to listen doing other things and as you say the technical things are missed. I'll do that this week.
Heliobas Disciple
TB Fanatic
In light of Geert's latest interview, here's an interesting article. The writer added in a bunch of snarkiness about how money is being spent in the UK instead of on public health. Rather than throwing out the baby with the bathwater, I just deleted those parts with this [...] and kept the relevant parts.
www.thailandmedical.news
(fair use applies)
UK Medical News: COVID-19 Infections In Britain Reach Highest Levels As British Government Halt Collation Of COVID Data. Imminent Catastrophe Coming
Thailand Medical News
March 26, 2023
COVID-19 cases in the United Kingdom have climbed to their highest levels since the beginning of the year, with an estimated 1.7 million people in private households likely to have had the virus in the week ending 13 March according to the last ONS (Office for National Statistics) COVID-19 infection survey report.
Zoe app COVID-19 statistic show that there were about 114,359 new symptomatic COVID-19 infections for the 24th of March 2023.
health-study.joinzoe.com
COVID-19 Hospitalizations in the UK are also rising according to some online reports.
View: https://mobile.twitter.com/LawrenceGilder/status/1638973057615163400
COVID-19 weekly average death rates according to official figures comes hover between 550 the last few weeks to about 600 in the last week.
Due to dubious methods of data collation imposed by the British public health authorities, COVID-19 death rates and excess death rates are speculated to be much higher in the rate of 6 to 7-fold.
Various XBB sub-lineages are behind the new onslaught in the United Kingdom including the XBB.1.9.1 and EG.1 (XBB.1.9.2.1)
cov-spectrum.org
The situation according to some are expected to worsen in coming weeks in the United Kingdom and also in many parts of Europe!
View: https://mobile.twitter.com/edwinhayward/status/1639427891665719296
While COVID-19 Infections are rising in the country, the British government has decided to axe the Office for National Statistics (ONS) survey which provides official estimates of UK infections due to costing issues.
[...]
The survey has provided valuable weekly data on virus levels, antibody levels, and long COVID, allowing successive waves and new variants to be identified and tracked.
Oxford University virologist Professor Aris Katzourakis called the decision "incomprehensible" and warned that the UK could be "fighting blind" against COVID in the absence of regular updates. He believes this is a disservice to public health and scientific advancement, as people will now have to rely on secondary analysis, such as that provided by the COVID ZOE app, to monitor developments.
According to latest UK Medical News updates, in England, the estimated percentage of individuals testing positive for COVID increased in the North West, East Midlands, and South East. The figure also increased among children aged two to 15/16 years old and those aged 50 and over, with uncertain trends in the remaining age groups.
Thomas House, professor of mathematical statistics at Manchester University and one of the academic collaborators on the survey, acknowledged the survey's high cost but expressed disappointment at its termination. He suggested that the survey could have been scaled down instead of being stopped entirely, as the long-term prevalence of COVID and the potential challenges of the upcoming winter remain unknown.
Interestingly, a Muslim in Britain, Professor Majeed Azeem, head of public health at Imperial College London commented that the ONS survey cost was high and also argued that it is time to treat COVID like other infections. He emphasized that the National Health Service (NHS) and public spending are under pressure and that funds allocated to the survey could be spent elsewhere. [...]
Despite its value to public health, active surveillance, such as the ONS survey, is expensive and not routinely performed outside of an active health emergency. Mark Woolhouse, professor of infectious disease epidemiology at Edinburgh University, stressed the importance of maintaining the capacity to perform such surveys when needed.
In the absence of official estimates, hospital admissions and death registrations will be among the few remaining sources of data to provide insight into the prevalence of the virus but even that is being manipulated by reporting strategies imposed by the Tories.
As COVID-19 cases continue to rise in the UK, the lack of official infection estimates places greater importance on alternative methods for monitoring the virus's spread. Many experts warn that the ONS survey's cancellation could leave the UK "fighting blind" against COVID.
Professor Katzourakis suggested that the increase in cases could be due to waning immunity or a variant-driven wave. However, without official variant data, determining the cause remains unclear. The termination of the ONS survey leaves the UK with limited tools to assess the potential impact of new variants or other unforeseen developments in the pandemic.
Michelle Bowen, ONS head of health surveillance dissemination, stated that while infections are rising in England, the trend remains uncertain across the rest of the UK. She noted that positivity increased in children and those aged 50 and over, with infections also increasing in the North West, East Midlands, and South East of England. However, the trend in other regions remains uncertain.
Sir David Spiegelhalter, emeritus professor of statistics at Cambridge University and chairman of the advisory board for the survey, praised the survey as an "extraordinary achievement" that provided "vital evidence of great value both to national policy and international scientific understanding." He acknowledged the survey's high cost but emphasized that the participant group is not being disbanded, and the survey could ramp up when necessary.
As the UK moves towards living with COVID, a policy peddled by those controlling to COVID-19 narratives, more people are expected to die and millions more expected to live with debilitating conditions due to Long COVID. We can expect to see excess death rates shoot up exponentially. [...]
UK Medical News: COVID-19 Infections In Britain Reach Highest Levels As British Government Halt Collation Of COVID Data. Imminent Catastrophe Coming! - Thailand Medical News
UK Medical News: COVID-19 cases in the United Kingdom have climbed to their highest levels since the beginning of the year, with an estimated 1.7 million people in private households likely to have had the virus in the week ending 13 March according to the last ONS (Office for National...
www.thailandmedical.news
UK Medical News: COVID-19 Infections In Britain Reach Highest Levels As British Government Halt Collation Of COVID Data. Imminent Catastrophe Coming
Thailand Medical News
March 26, 2023
COVID-19 cases in the United Kingdom have climbed to their highest levels since the beginning of the year, with an estimated 1.7 million people in private households likely to have had the virus in the week ending 13 March according to the last ONS (Office for National Statistics) COVID-19 infection survey report.
Coronavirus (COVID-19) latest insights - Office for National Statistics
The latest data and trends about the coronavirus (COVID-18) pandemic from the Office for National Statistics and other sources.
www.ons.gov.uk
Zoe app COVID-19 statistic show that there were about 114,359 new symptomatic COVID-19 infections for the 24th of March 2023.
Latest Daily UK COVID-19 Data: Vaccines, Cases, Trends | ZOE
COVID infection & vaccination rates in the UK today, based on public data and reports from millions of users of the ZOE Health Study app
health-study.joinzoe.com
COVID-19 Hospitalizations in the UK are also rising according to some online reports.
View: https://mobile.twitter.com/LawrenceGilder/status/1638973057615163400
COVID-19 weekly average death rates according to official figures comes hover between 550 the last few weeks to about 600 in the last week.
Due to dubious methods of data collation imposed by the British public health authorities, COVID-19 death rates and excess death rates are speculated to be much higher in the rate of 6 to 7-fold.
Various XBB sub-lineages are behind the new onslaught in the United Kingdom including the XBB.1.9.1 and EG.1 (XBB.1.9.2.1)
covSPECTRUM
covSPECTRUM is an interactive platform aiming to help scientists investigate and identify variants of SARS-CoV-2.
cov-spectrum.org
The situation according to some are expected to worsen in coming weeks in the United Kingdom and also in many parts of Europe!
View: https://mobile.twitter.com/edwinhayward/status/1639427891665719296
While COVID-19 Infections are rising in the country, the British government has decided to axe the Office for National Statistics (ONS) survey which provides official estimates of UK infections due to costing issues.
[...]
The survey has provided valuable weekly data on virus levels, antibody levels, and long COVID, allowing successive waves and new variants to be identified and tracked.
Oxford University virologist Professor Aris Katzourakis called the decision "incomprehensible" and warned that the UK could be "fighting blind" against COVID in the absence of regular updates. He believes this is a disservice to public health and scientific advancement, as people will now have to rely on secondary analysis, such as that provided by the COVID ZOE app, to monitor developments.
According to latest UK Medical News updates, in England, the estimated percentage of individuals testing positive for COVID increased in the North West, East Midlands, and South East. The figure also increased among children aged two to 15/16 years old and those aged 50 and over, with uncertain trends in the remaining age groups.
Thomas House, professor of mathematical statistics at Manchester University and one of the academic collaborators on the survey, acknowledged the survey's high cost but expressed disappointment at its termination. He suggested that the survey could have been scaled down instead of being stopped entirely, as the long-term prevalence of COVID and the potential challenges of the upcoming winter remain unknown.
Interestingly, a Muslim in Britain, Professor Majeed Azeem, head of public health at Imperial College London commented that the ONS survey cost was high and also argued that it is time to treat COVID like other infections. He emphasized that the National Health Service (NHS) and public spending are under pressure and that funds allocated to the survey could be spent elsewhere. [...]
Despite its value to public health, active surveillance, such as the ONS survey, is expensive and not routinely performed outside of an active health emergency. Mark Woolhouse, professor of infectious disease epidemiology at Edinburgh University, stressed the importance of maintaining the capacity to perform such surveys when needed.
In the absence of official estimates, hospital admissions and death registrations will be among the few remaining sources of data to provide insight into the prevalence of the virus but even that is being manipulated by reporting strategies imposed by the Tories.
As COVID-19 cases continue to rise in the UK, the lack of official infection estimates places greater importance on alternative methods for monitoring the virus's spread. Many experts warn that the ONS survey's cancellation could leave the UK "fighting blind" against COVID.
Professor Katzourakis suggested that the increase in cases could be due to waning immunity or a variant-driven wave. However, without official variant data, determining the cause remains unclear. The termination of the ONS survey leaves the UK with limited tools to assess the potential impact of new variants or other unforeseen developments in the pandemic.
Michelle Bowen, ONS head of health surveillance dissemination, stated that while infections are rising in England, the trend remains uncertain across the rest of the UK. She noted that positivity increased in children and those aged 50 and over, with infections also increasing in the North West, East Midlands, and South East of England. However, the trend in other regions remains uncertain.
Sir David Spiegelhalter, emeritus professor of statistics at Cambridge University and chairman of the advisory board for the survey, praised the survey as an "extraordinary achievement" that provided "vital evidence of great value both to national policy and international scientific understanding." He acknowledged the survey's high cost but emphasized that the participant group is not being disbanded, and the survey could ramp up when necessary.
As the UK moves towards living with COVID, a policy peddled by those controlling to COVID-19 narratives, more people are expected to die and millions more expected to live with debilitating conditions due to Long COVID. We can expect to see excess death rates shoot up exponentially. [...]
Heliobas Disciple
TB Fanatic
EXCLUSIVE On Rising: Dr. Robert Redfield RESPONDS After Fauci SLAMMED Him As 'Totally Wrong'
The Hill
24 min 46 sec
Former CDC Director Robert Redfield weighs in on the theory that Covid-19 came from lab versus reporting that maintains coronavirus came from racoon dogs. Originally aired March 20, 2023.
Heliobas Disciple
TB Fanatic
Sars-Cov-2 Kills T-Cells, Just Like HIV
It also works like HIV, via LFA-1 T-cell Receptors and gp120
igorchudov.substack.com
Sars-Cov-2 Kills T-Cells, Just Like HIV
It also works like HIV, via LFA-1 T-cell Receptors and gp120
Igor Chudov
Mar 14, 2022
Is Sars-Cov-2 airborne HIV? Two days ago, an interesting article came out:
This article was not written by a bunch of random scientists, but instead was written by people from the Wuhan Institute of Virology, including the infamous batwoman Shi Zheng-Li. Just keep this in mind. It was originally submitted in Sep 2021 and revised in January 2022, so it does not involve Omicron.
The article is saying the following:
- Many patients who had severe Sars-Cov-2 had “lymphopenia”, that is, depletion of the all important immune T lymphocyte cells
- This depletion was caused by cellular suicide (apoptosis) of T cells after infection
- In experimental setups involving infecting laboratory cell lines of human T cells, Sars-Cov-2 virus was able to penetrate and infect T cells
- This tropism (attraction to) T cells and ability to infect them was UNRELATED to the usual way Sars-Cov-2 infects other cells, such as lung cells, that express ACE2 and TMPRSS2 receptors, because T cells do not have those receptors.
- Infection of T cells occurs via “LFA-1, the protein [that] exclusively expresses in multiple leukocytes”
- It turns out that HIV’s gp120 protein is the one that “Activates LFA-1 on CD4 T-Lymphocytes and Increases Cell Susceptibility to LFA-1-Targeting Leukotoxin”
- I would like to remind you that HIV’s gp120 protein also was mysteriously transplanted into Sars-Cov-2
- Additionally, gp120 protein is located in the spike protein of Sars-Cov-2, and spike protein is used in all “Covid vaccines”.
Let’s look at this more closely:
Lymphopenia
T Lymphocytes are cells that are responsible for killing infected or cancerous cells.
T cells are a type of white blood cell known as a lymphocyte. Lymphocytes protect the body against cancerous cells and cells that have become infected by pathogens, such as bacteria and viruses. T cell lymphocytes develop from stem cells in bone marrow. These immature T cells migrate to the thymus via the blood. The thymus is a lymphatic system gland that functions mainly to promote the development of mature T cells. In fact, the "T " in T cell lymphocyte stands for thymus derived.
T cell lymphocytes are necessary for cell mediated immunity, which is an immune response that involves the activation of immune cells to fight infection. T cells function to actively destroy infected cells, as well as to signal other immune cells to participate in the immune response.
On this graph from the article, you can see dramatic declines in T cells, and also specific big declines of CD4 and CD8 cells:
For example, the picture above shows that both CD4 and CD8 cells decline.
Then the authors explain how they performed genetic tests to make sure that the T cells actually get infected:
HIV and Sars-Cov-2 Use gp120 to Enter T cells
The primary mechanism of AIDS is depletion of CD4 cells. For Sars-Cov-2, we see depletion of CD4 and CD8 cells as well. Science has long answered how HIV infects T cells (1991):
The news here is that Sars-Cov-2 also infects T cells, and Sars-Cov-2 also has the gp120 insert:
LFA-1 Receptor
Remember that for the last two years we have heard how Sars-Cov-2 infects cells expressing ACE-2 receptor ad TMPRSS2 protein. Guess what, our T-cells have neither of those!
So, how do they get infected? The WIV article that I am discussing, conveniently, found the mechanism: it is a so called LFA-1 receptor.
Amazingly enough, if you still believe in coincidences, HIV also uses the same LFA-1 receptor to enter lymphocytes, and uses the same gp120 protein to facilitate the entry.
Summary
From the articles cited, we can see that- Covid-19 causes lymphocytopenia (depletion of lymphocytes) in real life patients
- HIV causes depletion of lymphocytes also
- Both Sars-Cov-2 and HIV use the same receptor LFA-1 to enter T cells
- HIV uses gp120 protein to bind to LFA-1 receptor
- Sars-Cov-2 also has gp120 insert as well, mysteriously
The bats, sitting it Chinese caves a thousand miles from WIV, were clearly very smart when they decided to add gp120 to their natural coronaviruses!
Word of Caution
Before we all get overly excited, please note that this is very much work in progress. I believe very strongly that most people who have mild Covid do NOT develop permanent lymphopenia.How do I know? I am one of them.
My own Test Results
Very conveniently, I had blood tests before, during and after my own Covid. My health care provider lets me see the history of my test results. This became very handy when writing this article.They show, amazingly, that during Covid I did actually have much reduced lymphocytes, that fortunately recovered. During Covid, which was relatively mild, my lymphocytes dropped almost to the lowest range!
Fortunately, 10 months after infection, they recovered. I am NOT vaccinated. Experience of vaccinated people may vary.
Covid Vaccine Spike Protein Causes Lymphopenia Also
So, spike protein in Sars-Cov-2 has gp120, we know that it affects lymphocytes, and “Covid Vaccines” also make spike protein.A question arises, does “Covid Vaxx” also cause lymphopenia?
A search on OpenVaers reveals 312 reports of lymphopenia, spanning 26 pages:
Obviously, the real number of instances of lymphopenia after vaccination is much higher that openVAERS entries, for many obvious reasons. I will let someone else research that.
.
Heliobas Disciple
TB Fanatic
Ralph Baric's Description of the "Perfect Bioweapon" Sounds Awfully Similar to Sars-Cov-2
Those "HIV Inserts" in Sars-CoV-2 are not just random sequences after all
igorchudov.substack.com
Ralph Baric's Description of the "Perfect Bioweapon" Sounds Awfully Similar to Sars-Cov-2
Those "HIV Inserts" in Sars-CoV-2 are not just random sequences after all
Igor Chudov
5 hr ago
SUMMARY: The Sars-Cov-2 virus that causes COVID-19 contains genetic fragments of HIV. This post will show that numerous scientific studies created recombinant viruses containing genes from HIV. Thus, it should not surprise anyone that a lab-engineered pathogen such as Sars-Cov-2 is a recombinant carrier of HIV genes and expresses HIV peptides such as Gp120 or Gag.
HIV Inserts in Sars-Cov-2
You may have heard that Sars-Cov-2 contains certain genes from HIV, which causes AIDS. Those genes encode proteins that go into Covid-19’s “spike protein.” Thus, anyone who had Covid or received the Covid vaccine containing the same spike protein was exposed to the HIV peptides on the spike.The above-mentioned proteins fold together, forming a functional equivalent of HIV’s gp120, as explained here.
This picture from the above article shows visually where these HIV peptides are on the spike:
Far from being random pointless genetic artifacts, these HIV peptides bind to immune cells and cause their destruction.
Fact Checks Describe this as a Baseless Conspiracy Theory
The press made significant efforts to discredit the “HIV genes in Sars-CoV-2” theory.
https://www.factcheck.org/2020/02/baseless-conspiracy-theories-claim-new-coronavirus-was-bioengineered/
https://www.forbes.com/sites/victoriaforster/2020/02/02/no-coronavirus-was-not-bioengineered-to-put-pieces-of-hiv-in-it/?sh=4892d4fc56cb'
Are these fact checks factual? Is “HIV in Sars-CoV-2” a baseless right-wing conspiracy theory? Most importantly, was similar research done before?
NIH Funded Similar Coronavirus Recombinations
Scientists experimented with putting HIV and SIV (Simian Immunodeficiency Virus) bits into coronaviruses in the past, and the NIH supported such work.
In this 2008 grant, Amy Sims, who worked with Ralph Baric at UNC, describes her idea to put bits of Simian Immunodeficiency Virus (SIV, a precursor of HIV) into a human common cold virus OC43. (you probably had a few colds caused by OC43, which causes one-third of common colds). Amy then experimented with infecting monkeys with it.
There were numerous other attempts to add HIV genes to measles, poxviruses, and coronaviruses, specifically:
As all HIV vaccines failed, and most made their recipients paradoxically more susceptible to becoming infected with HIV, the above-described 2008 work did not lead to a working HIV vaccine. In addition, Amy’s discussion of “mucosal immunity” against HIV seems to be at odds with the fact that HIV is blood-borne and is passed through contaminated drug needles, razors, or sexual acts where blood is exchanged (such as unprotected anal sex).
Adding bits and parts of HIV to viruses was the bread and butter of virology. Thus, the fact-checks that deny the possibility that HIV inserts in SARS-Cov-2 were engineered are less than truthful.
Here’s Luc Montagnier, a pioneer in the field of HIV, who coincidentally died soon after giving this interview, explaining that Sars-Cov-2 was engineered:
2 min 26 sec
And lastly, here’s a brand-new Mar 24 interview with Robert Redfield, former director of the CDC who also worked on HIV and HIV vaccines with Anthony Fauci and Debora Birx, explaining that Sars-Cov-2 is a product of mostly US-based research:
24 min 46 sec
Was SARS-CoV-2 a “Live Vaccine” or an Engineered Pathogen?
Many people opined that Sars-CoV-2, the virus that causes COVID-19 was an attempt at creating a live vaccine that went spectacularly wrong. After all, some above-described experiments involved the creation of vaccines. The first peer-reviewed article that asserted that Sars-Cov-2 was engineered, written by Karl and Dan Sirotkin, alleged that the virus was created as a live vaccine.While everything is possible, I doubt that story. The reasons for my doubt are as follows:
- Attempts to create a coronavirus-based HIV vaccine failed a long time ago (see above)
- There is no reason to add a furin cleavage site, which enhances infectivity and pathogenicity, to a vaccine
- There is no reason to pick a “backbone” (an original virus that forms the basis of) for Sars-Cov-2 that was not already known to science
The preparations are listed here:
Igor’s Newsletter
Ralph Baric Described His Perfect Bioweapon
Ralph Baric has devoted a lot of thinking to biological weapons.
Here’s a fascinating article from him:
https://www.jcvi.org/sites/default/files/assets/projects/synthetic-genomics-options-for-governance/Baric-Synthetic-Viral-Genomics.pdf
Ralph shows that recombinant pathogens combining genes from several pathogens will likely be the future bioweapon. He then explains that high pathogenicity is NOT necessary for a perfect bioweapon: instead, what is important is that the bioweapon creates fear.
He also details helpful suggestions for the creation of such designer super pathogens:
Ralph worked on related projects for years. It would make sense that he should be asked to help find the culprits who created Sars-CoV-2.
I am unsure if Ralph would have to go far beyond his office to point at the culprits.
Acknowledgments
When writing this post, I used information from a tweet from Pete Lincoln. Take a look at Pete’s substack. Also, I owe a hat tip to William Colby.What do you think?
Also, is there an additional topic that you would like me to cover in the future?
Last edited:
Zoner
Veteran Member
Just watched the video taking notes: Here they are.
Natural pandemics are not variant pandemics. This one is and variants have become dominant. (so indirectly saying this virus is not natural. i.e., bio-weapon).
This virus will become more virulent in time. Timing is off but still sure we will not escape the worse is yet to come.
The timeline was off because of SIR. The Immune system is refocusing. Also because of epitopes. Don’t understand the technical science of epitopes or virology. My eyes glazed over most the interview. Too technical for me.
he said there is just a delay and it helps the immune system catch up but the course cannot be changed. It is irreversible.
The omicron virus is continuing to evolve. Evolving in a bad direction.
Highly vaccinated populations are in the calm of the storm but they are in for a big surprise because they think the pandemic is over. But Science doesn’t know where this virus is headed.
He sees the prelude to what he has predicted. 46:00 (hospitalizations for different things) He sees that the virulence is increasing with hospitalizations (chronic illnesses etc.) The whole phenomenon is dynamic. The virus is evolving and nature is in charge. Still saying the unvaxxed are much better off because their innate immune is being trained.
How long will it be before it gets bad? The virus is evolving slowly. Will not be surprised if it happens in one week, two weeks, or three months. But it will happen. The price we will have to pay. He is 200% sure.
Everyone is thinking and saying the pandemic is over, that is why they will be surprised.
Furious at the silence of the scientists who know the truth.
In highly vaccinated countries Geert believes we will lose up to 1/3 of the population. Could envision the end of western civilization.
My take: Geert knows his stuff. I'm impressed with his expertise. He has nothing to gain to say what he is saying. He is seeing the prelude to what he has predicted so it's just a matter of time. We're on our own folks. Thank God for Jesus.
Heliobas Disciple
TB Fanatic
Thank you. You did a great job, and you motivated me to take notes for this next video I'm about to post
HD
Heliobas Disciple
TB Fanatic
I apologize for spellling errors, I was typing pretty fast to keep up.
View: https://www.youtube.com/watch?v=Os7U8jYjwXE
When Geert Speaks, the World Listens
Vejon Health
1 hr 6 min 4 sec
Dr. Philip McMillan talking to Geert Vanden Bossche (Vaccinologist) about his new book, looking at what has been learnt over the 3 years of the COVID-19 pandemic. With Dr Shankara Chetty - Covid hero from South Africa.
- Geert: unbelievable to him that his book would be censored. He's trying to bring science. Is it censorship or because it's printed and edited in europe? Very clear that Amazon has not come up with a clear cut answer. very mysterious what's going on. Can't rule out censorship, very embarrasing to him.
- Geert: goal to document the complexity of the pandemic. If laymen read it, will be very difficult. Some section they won't understand but what's important for him is that even laymen will realize these things are complex. And as a result of immune intervention it's even more complex and very dynamic. if the only message that laymen get out of it is that it's more complex than people are being led to believe, it's an achievement. It's for health experts, scientists peers. A lot of immunology, in his humble opinion, the element most ignored is the immunology. it's evolving. There are all kinds of antibodies. Immune response evolving as the virus evolves. Wanted to document it, illustrate the scientific rationale so no one could say this was unpredictable, no one could know this... no, there is a way to understand this. Very clear to him that nothing more predictable than this mass intervention would not have a happy end. Did his best to document this.
- Geert: Impact of mass vaccination on the population. People were worried about the vulnerable. To protect them, like flu vaccine. To extrapolate this to all of the population - no need to do that. Prophylactic vaccines, if given before exposed, but this no longer true when vaxxed during the pandemic because no sterilizing immunity. So textbook example of immune escape. Still unbelievable to him they did this.
- Geert: immune response of someone infected vs. vaxxed is different. One element has been completely ignored in this approach was natural immunity and innate immunity. Unvaxxed develope a differnt type of immune response. Being immunology naive when they were exposed, virus spreads, 90% protected because of innate immunity. The first line of immune defense takes out the bulk of the viral load. Explains why naturally induced antibodies have lower titers and decline - because innate immune system took it out already so adaptive immune is weak, not needed. But vaxxed don't stimulate the innate immunity, they use the vaccinal antibodies. Innate immunity can acquire adapted immunity too, so whereas vaccinal antibodies are highly specific and dimished capacity when virus changes, the unvaxxed trained innate immunity is better because not pathogen specific. Immune status of a vaccinee is completely different from an unvaxxed person.
-Shankara explained further that the natural immunity defense is short lived, after the virus it goes away so you have a clean slate for it to react to the next variant, a clean slate. the vaxxed immunity is long lived so they have the same slate that won't work for the new variant, and it can't adapt.
- Geert: not damaged, won't say that - sidelining the innate immune system. when the vaccine antibodies lose their neutralizing capacities, you generate NonNeutralizing Antibodies that bind to the virus. they can speed up the infectiousness to extent innate immune system is sidelined. No longer trained. Not damaged, not destroyed, it's just sidelined. So not trained so body can't rely on it. That's the important line of immune defense and it's sidelined. Critical problem as virus is evolving.
- Shankara: trying to get herd immunity with non-neutralizing vaccine is nonsenical.
- Geert: studying antibodies with long affinity - neutralizing capcities diminishes with omicron, you get vaccine breakthrough infections. Antibodies were elicited by vaxx don't recognize the new variant with sufficient afinity. They can bind even if not neutralizing. Low afinity antibodies - he thinks this is very important, they can still recognize the dominant epitopes, they can mask them. The ones who weren't dominant, are now exposed with immune refocusing. These antibodies are igg4 subtype. These antibodies, and maybe this is why they provoke tolerance, they hamper uptake to antigen presenting cells. (this is getting too technical to take notes!)
- Geert: relevance to day to day life? He wants to know about these antibodies is what is their function. It seems likely that ultimately vaccine breakthrough infection leads to more non-neutralizing antibodies. Is anyone measuring or characterizing them? If this is the case of repeated breakthrough infections continue to stimulate and boost their non-neutralzing antibodies. these are the ones that are right now are still prtoecting from severe disease. But they are weak, they are temporal, unless continually stimulated by reinfection. but this puts immune pressure on severe disease. How immune response is changing as a function of evolving virus, we have to study this.
- shankara: you develop NonNeutralizing Antibodies. That prevents severe illness. But they are non-neutralizing. At this point, we see decrease in severe illness. but the vaxxed are developing NNA. That puts pressure on the virus itself. Virus can be more infectious or more virulence. The contagiousness will reach it peak, because nna prevent death, the virus will mutate into more virulence to overtake this.
- Geert: we have made this mistake with omicron. Omicron was highly infectious, spreading... people were saying this is fantastic, this will boost vaccine immunity. Variants keep coming, they are not posing severe disease, but they are still very infectious. where to do we have in any history any example that becomes more infectious that can't be neutralized by neutralizing antibodies that becomes endemic. Golden rule - if you can't stop transmission, you can't stop virus. We don't have sterilizing immunity.
- Philip: even though we're not seeing severe disease, but we are seeing excess mortality. Shankara: we seen increase to excess deaths not from covid, that's from the pathogenicity of spike protein itself. (gets very technical on spike protein). Biodistribution in cells around the body we're going to see a wide auto immune reaction to address the foreign protein. So vaxx is double edged sword - it causes these immune problems of the NNA on the one hand, and on the other hand we have the pathogenicity of spike protein on its own and vaccine makes it in the body we see the long term biological effects of spike protein.
- what would Geert tell them now. Geert: It's increasing difficult to get out of this. Omicron is point of no return. He's primarily concerned now of continuing evolution of virus to immune pressure. So if that is the concern, at this stage where it becomes more tricky, suppression of severe disease, that MIGHT be lifted, in the past he said let's do very early treatment; virus is now highly infectious, tehre might be a risk of enhanced severe disease, anti-virals now prophylactically - don't wait for disease. We have to correct with mass prophylactic antivirals. that would bring down the transmission, along with the unvaxxed, so can control the virus. highly vaxxed countries would need it to high level of population. He clearly says in his book there will be a certain percentage of vaccinees who will still be protected as the unvaxxed (not mrna). When they were exposed, now many boosted. There is a grey zone in between. Unvaxxed have to stay in good health to be immune. He has no recommendations of how to get out of this. Omicron will be remembered in history as the point of no return, self fueling large scale immune escape breakthrough infections. We can't stop it now, he's very concerned about.
- Shankara: we'll see a lot of morbidity and mortality we can't explain going forward. Use anti-virals liberally. stop vaxx. Look at anti-virals, give liberally. Unvaxxed are safe, their threat is a new variant that they don't have immunity to from the vaxxed. But he's sure they can train their immunity. And that doesn't even take into acct the side effects of the vaxx itself.
Closing thoughts:
Shankara : for everyone, no more vaccinations. We need to detox from spike protein. Vitamin D, exercise, sunlight, peak health. Waiting for delayed reaction thats to come.
Geert: now primarily up to clinicians to be very vigilant. In highly vaxxed countries we have been profoundly a natural balance between a pathogen and the host immune system. His fear is that we are at a tricky point, we need to do the best we can when people succumb to more virulent variants to save lives. use antivirals when the virulence appears to save lives. Avoid the health system crashing.
Shankara: when dealing with population dynamics, even the slightest adjustments have profound changes. we've increased the deaths, we've decreased fertlity. And just those two can lead to extinction to humanity as we know it. That's how profound this is. Vital for people to understand the impact on humanity. Trust nature to restore balance, stop interfering with it.
They had a chat and q& a after the youtube part of the video ended (don't know where you can see it?)
When Geert Speaks, the World Listens
Vejon Health
1 hr 6 min 4 sec
Dr. Philip McMillan talking to Geert Vanden Bossche (Vaccinologist) about his new book, looking at what has been learnt over the 3 years of the COVID-19 pandemic. With Dr Shankara Chetty - Covid hero from South Africa.
- Geert: unbelievable to him that his book would be censored. He's trying to bring science. Is it censorship or because it's printed and edited in europe? Very clear that Amazon has not come up with a clear cut answer. very mysterious what's going on. Can't rule out censorship, very embarrasing to him.
- Geert: goal to document the complexity of the pandemic. If laymen read it, will be very difficult. Some section they won't understand but what's important for him is that even laymen will realize these things are complex. And as a result of immune intervention it's even more complex and very dynamic. if the only message that laymen get out of it is that it's more complex than people are being led to believe, it's an achievement. It's for health experts, scientists peers. A lot of immunology, in his humble opinion, the element most ignored is the immunology. it's evolving. There are all kinds of antibodies. Immune response evolving as the virus evolves. Wanted to document it, illustrate the scientific rationale so no one could say this was unpredictable, no one could know this... no, there is a way to understand this. Very clear to him that nothing more predictable than this mass intervention would not have a happy end. Did his best to document this.
- Geert: Impact of mass vaccination on the population. People were worried about the vulnerable. To protect them, like flu vaccine. To extrapolate this to all of the population - no need to do that. Prophylactic vaccines, if given before exposed, but this no longer true when vaxxed during the pandemic because no sterilizing immunity. So textbook example of immune escape. Still unbelievable to him they did this.
- Geert: immune response of someone infected vs. vaxxed is different. One element has been completely ignored in this approach was natural immunity and innate immunity. Unvaxxed develope a differnt type of immune response. Being immunology naive when they were exposed, virus spreads, 90% protected because of innate immunity. The first line of immune defense takes out the bulk of the viral load. Explains why naturally induced antibodies have lower titers and decline - because innate immune system took it out already so adaptive immune is weak, not needed. But vaxxed don't stimulate the innate immunity, they use the vaccinal antibodies. Innate immunity can acquire adapted immunity too, so whereas vaccinal antibodies are highly specific and dimished capacity when virus changes, the unvaxxed trained innate immunity is better because not pathogen specific. Immune status of a vaccinee is completely different from an unvaxxed person.
-Shankara explained further that the natural immunity defense is short lived, after the virus it goes away so you have a clean slate for it to react to the next variant, a clean slate. the vaxxed immunity is long lived so they have the same slate that won't work for the new variant, and it can't adapt.
- Geert: not damaged, won't say that - sidelining the innate immune system. when the vaccine antibodies lose their neutralizing capacities, you generate NonNeutralizing Antibodies that bind to the virus. they can speed up the infectiousness to extent innate immune system is sidelined. No longer trained. Not damaged, not destroyed, it's just sidelined. So not trained so body can't rely on it. That's the important line of immune defense and it's sidelined. Critical problem as virus is evolving.
- Shankara: trying to get herd immunity with non-neutralizing vaccine is nonsenical.
- Geert: studying antibodies with long affinity - neutralizing capcities diminishes with omicron, you get vaccine breakthrough infections. Antibodies were elicited by vaxx don't recognize the new variant with sufficient afinity. They can bind even if not neutralizing. Low afinity antibodies - he thinks this is very important, they can still recognize the dominant epitopes, they can mask them. The ones who weren't dominant, are now exposed with immune refocusing. These antibodies are igg4 subtype. These antibodies, and maybe this is why they provoke tolerance, they hamper uptake to antigen presenting cells. (this is getting too technical to take notes!)
- Geert: relevance to day to day life? He wants to know about these antibodies is what is their function. It seems likely that ultimately vaccine breakthrough infection leads to more non-neutralizing antibodies. Is anyone measuring or characterizing them? If this is the case of repeated breakthrough infections continue to stimulate and boost their non-neutralzing antibodies. these are the ones that are right now are still prtoecting from severe disease. But they are weak, they are temporal, unless continually stimulated by reinfection. but this puts immune pressure on severe disease. How immune response is changing as a function of evolving virus, we have to study this.
- shankara: you develop NonNeutralizing Antibodies. That prevents severe illness. But they are non-neutralizing. At this point, we see decrease in severe illness. but the vaxxed are developing NNA. That puts pressure on the virus itself. Virus can be more infectious or more virulence. The contagiousness will reach it peak, because nna prevent death, the virus will mutate into more virulence to overtake this.
- Geert: we have made this mistake with omicron. Omicron was highly infectious, spreading... people were saying this is fantastic, this will boost vaccine immunity. Variants keep coming, they are not posing severe disease, but they are still very infectious. where to do we have in any history any example that becomes more infectious that can't be neutralized by neutralizing antibodies that becomes endemic. Golden rule - if you can't stop transmission, you can't stop virus. We don't have sterilizing immunity.
- Philip: even though we're not seeing severe disease, but we are seeing excess mortality. Shankara: we seen increase to excess deaths not from covid, that's from the pathogenicity of spike protein itself. (gets very technical on spike protein). Biodistribution in cells around the body we're going to see a wide auto immune reaction to address the foreign protein. So vaxx is double edged sword - it causes these immune problems of the NNA on the one hand, and on the other hand we have the pathogenicity of spike protein on its own and vaccine makes it in the body we see the long term biological effects of spike protein.
- what would Geert tell them now. Geert: It's increasing difficult to get out of this. Omicron is point of no return. He's primarily concerned now of continuing evolution of virus to immune pressure. So if that is the concern, at this stage where it becomes more tricky, suppression of severe disease, that MIGHT be lifted, in the past he said let's do very early treatment; virus is now highly infectious, tehre might be a risk of enhanced severe disease, anti-virals now prophylactically - don't wait for disease. We have to correct with mass prophylactic antivirals. that would bring down the transmission, along with the unvaxxed, so can control the virus. highly vaxxed countries would need it to high level of population. He clearly says in his book there will be a certain percentage of vaccinees who will still be protected as the unvaxxed (not mrna). When they were exposed, now many boosted. There is a grey zone in between. Unvaxxed have to stay in good health to be immune. He has no recommendations of how to get out of this. Omicron will be remembered in history as the point of no return, self fueling large scale immune escape breakthrough infections. We can't stop it now, he's very concerned about.
- Shankara: we'll see a lot of morbidity and mortality we can't explain going forward. Use anti-virals liberally. stop vaxx. Look at anti-virals, give liberally. Unvaxxed are safe, their threat is a new variant that they don't have immunity to from the vaxxed. But he's sure they can train their immunity. And that doesn't even take into acct the side effects of the vaxx itself.
Closing thoughts:
Shankara : for everyone, no more vaccinations. We need to detox from spike protein. Vitamin D, exercise, sunlight, peak health. Waiting for delayed reaction thats to come.
Geert: now primarily up to clinicians to be very vigilant. In highly vaxxed countries we have been profoundly a natural balance between a pathogen and the host immune system. His fear is that we are at a tricky point, we need to do the best we can when people succumb to more virulent variants to save lives. use antivirals when the virulence appears to save lives. Avoid the health system crashing.
Shankara: when dealing with population dynamics, even the slightest adjustments have profound changes. we've increased the deaths, we've decreased fertlity. And just those two can lead to extinction to humanity as we know it. That's how profound this is. Vital for people to understand the impact on humanity. Trust nature to restore balance, stop interfering with it.
They had a chat and q& a after the youtube part of the video ended (don't know where you can see it?)
Zoner
Veteran Member
Good job HD. You're able to follow the tech of this better than me.
Here's the ling to the short chat after the conference: After Conference discussion with Geert and Shankara
Heliobas Disciple
TB Fanatic
THANK YOU!!!!
Here are my notes after listening:
Geert: before the corona virus crisis started he had a rough time, he was lucky enough to rectify the situation with his family. It strengthened him, he's very strong. So not suffering from the criticism. His family and friends, no one is vaxxed so no tension, very relaxed. Very important not to make big mistakes. They are heavily scrutinized, and if they are right, they are criticized, so having relaxing family life is helpful. Convinced his message should be taken seriously and that drives him, that's his passion. A unique moment in history, we must keep fighting for truth. Passion for truth.
Philip - going into toughest period. challenging. for next 15-20 years we will have to look thru a spectrum of covid -19, every specialty will be effected for that long. Changes trajectory of society. He made a prediction that he thought he'd see 100 million excess deaths, the more he hears and observes he still thinks it will happen. He just can't tell time.
Geert: initially he thought it would go very very fast. The immune escape. But the immune refocusing changes that, the mrna vaxx, neutralizing antibodies, etc. That's the result of immune refocusing. Gave the immune system a break, delayed evolution for some time. The evolutionary sense delayed the time line. So he's now cautious about pronouncing time lines, not because of first error, but because what is happening right now it might be very well the case the virus is changing through glycocillation (?) profiles. We have no experience or documentation how under immune pressure glycocillation patterns and profiles can get modified and what kind of time this takes. So he really doesn't know. But maybe the increase in hospitalizations we are starting to see, a little bit more mortality, may be the prelude. The situation is becoming extremely complex. We are dealing with a virus that completely changed its behavior, very different from Wuhan version. It possibly can go to other organs, liver, spleen, etc not just lungs. Also the issue with the spike. They start to overlap so since nothing is still typical, and complication with side effects, a very complex pathology we don't know the agent causing all of this.
Shankara: It's a complete nightmare to treat. Getting symptoms that you can't associate with pathologies you trained with. You have to be very vigilant to know what pathologies spike protein is causing. Time line, look at population to predict timeline. It's like a piece of paper blowing across the yard. You know the direction but you don't know when the paper will actually get there. But you know the wind direction. So over a period of a month or 2 it can all of a sudden explode. All that's required is for the circulating variants to select for the most virulent one.
Geert: what about shedding. Nowadays what they mean is usually shedding of spike protein, I will leave to Shankara. It's not viral shedding, it's vaxx shedding, so he will pass on discussing because he's a virologist (TOO BAD, I WISH HE WOULD WEIGH IN ON IT FROM HIS PAST EXPERIMENTS!) . As far as viral shedding of the virus itself goes, under impression because of recurrent infection and the activation of CTL's in vaccinees, the viral shedding may be diminished, which puts pressure on replication of virus. If that route of transmission is diminished because shedding is diminished, so virus can't be transmitted easily to another person, so to sustain its survival will spread in the body of the host and disseminate in body so that is higher virulence. But shedding spike how it can contaminate non vaxxed, he always found this a very difficult question so leave it to Shankarra.
Shankarra: shedding is well document, it occurs. Menstrual irregularities, breast milk. It can be shed by exosomes, thru bodily fluids, as well as mrna shedding through exosomes and bodily fluids. Not same impact as vaccine, he's doubtful of that. but it does occur. How long? many studies, a lot of variation in that. Some studies show up to 60 days can shed.
Geert: (Bulgaria and the WHO question, implying Geert was planning on going to Bulgaria becasue they didn't sign WHO treaty). Answer: This has nothing to do with WHO. Can't write a book like he did and realize it might not have a happy end. It's logic, he's not panicking, not obsessed, but he has a plan B. Plan B one of the things, if it becomes a really bad situation wouldn't it be good to have a possibility to spend some time in a country that he can drive to that has a low vaccination rate. In Europe is Bulgaria. So that's why he asked about Bulgaria. In regard to treaty, doesn't believe in these things, nature will determine, not mankind.
Philip: were nations deceived by pharmaceuticals? How do you get the public to believe this was just an oversight.
Shankara: impossible. Populations aren't stupid. We have to redress what happened. It was about money, power, human rights, confirmed consent, our freedoms, our constitutions, our sovereignty. People who did it need to justify what happened,
Geert; agree with Shankarra. Pointing to trigger to institutions that made this possible. From very beginning he reached out to WHO in 2021, everybody knows they are dependent financially. They made a huge mistake making it a health emergency of international concern without having the vaccines themselves so opened the door to big pharma. He worked for big pharma. It's not about health, it's about enriching share holders. So when you open door to be pharma, you know what you will get and you decide to open it massively, in an environment where there is no competition between companies, so built an alliance, chaperoned by WHO, with politicians being puppets. It's all about money, and agendas, and hiding. Becomes worse and worse. Doesn't know who will be accountable, so much happened behind curtains we don't know, the contracts that were signed, it's appalling.
Geert; (question: after bad virus arrives, how long to herd immunity.) think in terms of diminishing viral transmission. 2 possibilities, sterilizing immunity developed by unvaxxed and the other possibility for vaxxed in higher vaxxed countries is to prevent them from transmitting. Hospitalized or one way or another to disappear. The transmission can be reduced to a level we truly eradicate it, instead of driving into endimicity. How long will it take, depends on percentage of unvaxxed, how many shots the vaxxed got. Difficult to say. He can not imagine if this starts that it will take a long time. It will be very serious, big wave, will develop independently in different countries, won't be a lot of transmission, but each country will get this outcome on its own. To clear the virus, depends on whether they implement antivirals, which vaccines, percentage of vaxxed, how many unvaxxed. Difficult to stay. Won't last for years and years. For virus itself, not the side effects and long term sequale or immune disturbance due to spike. But acute phase that will lead to herd immunity can't last a long time.
Shankaraa; vaxxing the young population is crazy, that is your herd immunity. Africa evaded the vaccine, not the pandemic.
Geert: they evaded the immune escape by not vaccinating.
Heliobas Disciple
TB Fanatic
COVID-19 Infection During Pregnancy Linked to Higher Risk of Neurodevelopmental Disorders
Further investigation through larger studies and extended monitoring is necessary to assess this potential risk. According to a new study published in JAMA Network Open, researchers at Massachusetts General Hospital, a member of Mass General Brigham, discovered that male newborns (but not females)
scitechdaily.com
COVID-19 Infection During Pregnancy Linked to Higher Risk of Neurodevelopmental Disorders
By Massachusetts General Hospital
March 27, 2023
Further investigation through larger studies and extended monitoring is necessary to assess this potential risk.
According to a new study published in JAMA Network Open, researchers at Massachusetts General Hospital, a member of Mass General Brigham, discovered that male newborns (but not females) born to mothers infected with SARS-CoV-2 during pregnancy are more likely to receive a neurodevelopmental diagnosis within the first year of birth.
Previous research has established connections between other infections during pregnancy and neurodevelopmental disorders in children, such as autism spectrum disorder, but it remains uncertain whether the same holds true for SARS-CoV-2. To shed light on this issue, the researchers analyzed electronic health records of 18,355 live births that occurred during the COVID-19 pandemic, with 883 (4.8%) of these births being to mothers who tested positive for SARS-CoV-2 during pregnancy.
Of the 883 SARS-CoV-2–exposed children, 26 (3.0%) received a neurodevelopmental diagnosis during the first 12 months of life. Among the SARS-CoV-2–unexposed offspring, 317 (1.8%) received such a diagnosis.
After accounting for race, ethnicity, insurance status, hospital type (academic center vs. community), maternal age, and preterm status, maternal SARS-CoV-2 positivity was associated with a nearly two-fold higher odds of a neurodevelopmental diagnosis at 12 months of age among male children. Maternal SARS-CoV-2 positivity was not linked with a higher risk in female children, however.
At 18 months, the effects were more modest in males, with maternal SARS-CoV-2 positivity linked to a 42% higher odds of a neurodevelopmental diagnosis at this age. Too few of the mothers were vaccinated to determine whether vaccination changed risk.
“The neurodevelopmental risk associated with maternal SARS-CoV-2 infection was disproportionately high in male infants, consistent with the known increased vulnerability of males in the face of prenatal adverse exposures,” says co–lead author Andrea Edlow, MD MSc, an associate professor of Obstetrics, Gynecology, and Reproductive Biology, and a Maternal-Fetal Medicine specialist at MGH.
Co–lead author Roy Perlis, MD MSc, associate chief of Research in the Department of Psychiatry and director of the Center for Quantitative Health at MGH, notes that larger studies and longer follow-ups will be required to reliably estimate or refute the risk observed. “We hope to continue to expand this cohort, and to follow them over time, to provide better answers about any longer-term effects,” he says.
Reference: “Sex-Specific Neurodevelopmental Outcomes Among Offspring of Mothers With SARS-CoV-2 Infection During Pregnancy” by Andrea G. Edlow, MD, MSc, Victor M. Castro, MS, Lydia L. Shook, MD, Sebastien Haneuse, Ph.D., Anjali J. Kaimal, MD, MAS and Roy H. Perlis, MD, MSc, 23 March 2023, JAMA Network Open.
DOI: 10.1001/jamanetworkopen.2023.4415
This study was supported by the National Institute of Mental Health, the National Institute of Child Health and Human Development, and the Simons Foundation.
Heliobas Disciple
TB Fanatic
Warning: Researchers Find New York City Rats Carry the COVID-19 Virus
A new study has demonstrated that rats are susceptible to infection with Alpha, Delta, and Omicron variants of SARS-CoV-2, the virus that causes COVID-19. Moreover, wild rats in the New York City municipal sewer systems and elsewhere in the city have been exposed to SARS-CoV-2. The study was publish
scitechdaily.com
Warning: Researchers Find New York City Rats Carry the COVID-19 Virus
By American Society for Microbiology
March 27, 2023
A new study has demonstrated that rats are susceptible to infection with Alpha, Delta, and Omicron variants of SARS-CoV-2, the virus that causes COVID-19. Moreover, wild rats in the New York City municipal sewer systems and elsewhere in the city have been exposed to SARS-CoV-2. The study was published recently in mBio, an open-access journal of the American Society for Microbiology.
“Our findings highlight the need for further monitoring of SARS-CoV-2 in rat populations for potential secondary zoonotic transmission to humans,” said study principal investigator Henry Wan, Ph.D., Professor and Director of the Center for Influenza and Emerging Infectious Diseases at the University of Missouri. “Overall, our work in this space shows that animals can play a role in pandemics that impact humans, and it’s important that we continue to increase our understanding so we can protect both human and animal health.”
Rats are widely distributed in urban communities in the United States. For example, New York City alone has approximately eight million wild rats. These wild rats have ample opportunities to interact with humans. Two previous studies suggested that rats in Asia (Hong Kong) and Europe (Belgium) were exposed to SARS-CoV-2; however, it is unknown which SARS-CoV-2 variant these rats were exposed to in both studies.
In the new study, the researchers set out to determine whether the SARS-CoV-2 virus in humans has been transmitted to the rat population in urban areas of the United States, specifically New York City, and if so, which SARS-CoV-2 variant caused those infections. The researchers also set out to determine whether (and which) SARS-CoV-2 variants in NYC can cause infections in rats.
“In Fall of 2021, U.S. Department of Agriculture (USDA) Animal and Plant Health Inspection Service (APHIS) sampled Norway rats (Rattus norvegicus) in New York City to look for evidence of SARS-CoV-2 infection,” said study coauthor Tom DeLiberto, D.V.M., Ph.D., SARS-CoV-2 Coordinator at USDA APHIS Wildlife Services. “Two trapping efforts were conducted during September and November with permission from the NYC Department of Parks and Recreation in and around locations surrounding wastewater systems. Most of the rats were trapped in city parks within Brooklyn, although some were captured near buildings outside of park boundaries.”
Biologists collected and processed samples from 79 rats for virological studies and genomic sequencing. The researchers found that the rats were exposed to SARS-CoV-2 and showed a possible link to the viruses that were circulating in humans during the early stages of the COVID-19 pandemic. Specifically, 13 of 79 rats (16.5%) tested positive. “To the best of our knowledge, this is one of the first studies to show SARS-CoV-2 variants can cause infections in the wild rat populations in a major U.S. urban area,” Dr. Wan said.
To further investigate rat susceptibility to SARS-CoV-2 variants, the researchers conducted a virus challenge study and showed that Alpha, Delta and Omicron variants (variants found in humans) can cause infections in rats (wild-type Sprague Dawley rats), including high replication levels in the upper and lower respiratory tracts and induction of both innate and adaptive immune responses. Susceptibility to infection varied by type of variant.
“Our findings highlight the need for further monitoring of SARS-CoV-2 in rat populations to determine if the virus is circulating in the animals and evolving into new strains that could pose a risk to humans,” Dr. Wan said. “SARS-CoV-2 virus presents a typical one-health challenge which requires collaborative, multisectoral and transdisciplinary approaches to fully understand such challenges.”
Reference: “SARS-CoV-2 Exposure in Norway Rats (Rattus norvegicus) from New York City” by Yang Wang, Julianna Lenoch, Dennis Kohler, Thomas J. DeLiberto, Cynthia Y. Tang, Tao Li, Yizhi Jane Tao, Minhui Guan, Susan Compton, Caroline Zeiss, Jun Hang and Xiu-Feng Wan, 9 March 2023, mBio.
DOI: 10.1128/mbio.03621-22
Heliobas Disciple
TB Fanatic
Young women given non-mRNA Covid jab were at increased risk of death
Some Covid jabs given to young women early in the Covid pandemic increased their chance of a heart related death by up 3.5 times an analysis from the Office for National Statistics has found.
Certain Covid vaccines might TREBLE risk of sudden cardiac death in women under 30, official data show
By John Ely Senior Health Reporter For Mailonline
Updated: 15:33 EDT, 27 March 2023
- Covid jabs, while overall safe, are linked to rare, and sometime fatal side affects
Covid jabs might raise the risk of sudden cardiac deaths in young women, official UK data revealed today.
Government analysts trawled through data from England's historic roll-out in order to re-check the safety profile of vaccines in under-30s.
No significant increase in deaths among the vaccinated was uncovered, debunking one of the biggest current conspiracy theories surrounding the lockdown-banishing scheme.
Although when the results were broken down further, experts found an elevated risk of cardiac-related deaths in women for one type of jab.
Data collected by the Office for National Statistics (ONS) showed women who got a non-mRNA jab were 3.5 times more likely to die of such ailments within 12 weeks of being vaccinated.
This chart shows the risk increased risk of cardiac death in young people in England following a Covid vaccination according to the ONS analysis. Coloured lines represent the risk recorded through the data. Each bracket shows the lower and higher estimates with the centre dot representing the overall average. A result grater than 1 indicates a greater risk of a cardiac death, while less than 1 is a reduced risk. Young women (pink lines) who got a non-mRNA Covid jab saw a 3.5 times higher risk of death in the 12 weeks post-vaccination. While increases in males deaths (blue) was also observed for non-RNA jabs and in some estimates for mRNA vaccines the ONS said the data range was too large for it to be considered as evidence of an increased risk
This was compared to after that time-frame, as opposed to the unvaccinated.
Looking at the figures this way allowed the ONS team to spot any noticeable link to vaccination.
Some deaths linked to vaccines might have been missed in official figures, hence the need to look at the data another way.
Non-mRNA jabs include ones made by AstraZeneca and Novavax, which were the only two available during the period the study covered.
Although, no data on specific vaccine brand was included in the analysis. In the US, the Johnson and Johnson was one of the non-mRNA jabs used.
Writing in the journal Nature, the ONS team concluded that 11 cardiac deaths in young women may be attributable to non-mRNA jabs.
However, the study doesn't directly prove that any deaths were caused by any vaccine.
Fatalities could, for example, have been from an unrelated health condition or even a Covid infection itself given the virus is known to cause similar cardiac effects.
Researchers said young women given non-mRNA jabs in the period studied tended to be classified as clinically vulnerable, hence why they were prioritized for jabs.
This factor may have explained their increased risk of death, the team suggested.
No similar heightened risk was found in men. Academics did not offer a reason as to why, however, as that was beyond the scope of the analysis.
Nor did they uncover any proof that mRNA jabs, such as ones made by Pfizer and Moderna, carried such risk.
That disproves a conspiracy theory beloved by anti-vaxxers that the mRNA shots are responsible for a wave of 'sudden' deaths.
Just 75 Brits have been killed by Covid vaccines, official statistics show. It equates to roughly one death for every 2.1million jabs dished out in the UK
In fact, the study, which also examined the general risk of death after testing positive for Covid , found unvaccinated young people had significantly higher chance of dying than the jabbed from 'all causes'.
Researchers opted to look at the 12 week period post vaccination as this was the original time period set between vaccination doses.
The analysis was based on data from between December 8 2020, when Covid jabs were first rolled out, until May 25 last year.
It included people in England between the ages of 12 and 29, with researchers looking at this group specifically in response to some studies pointing to a risk of cardiac diseases in young people post-Covid vaccination.
While credited with saving the nation from an endless lockdown and thousands of lives, Covid vaccines, like any medical treatment, aren't risk free.
For example, mRNA vaccines can, in extremely rare cases, cause myocarditis. This inflammation of the heart is particularly a risk for young men and boys.
And the AstraZeneca jab was withdrawn for the under-40s in the UK in April 2021 after it was linked to a rare, but life-threatening, risk of developing blood clots.
Vahé Nafilyan, a senior statistician at the ONS, said overall the study showed mRNA vaccines, which have now been used for the majority of vaccinated young Brits, are generally safe.
'We find no evidence the risk of cardiac or all cause death is increased in the weeks following vaccination with mRNA vaccines,' he said.
However, he added they did find that young women given a non-mRNA Covid jab had a 3.52 times higher chance of cardiac death in the 12 weeks after.
While a 3.52 times increase in risk seems large, it should be noted that the actual number of deaths is estimated to be relatively small.
It equates to six cardiac deaths per 100,000 females vaccinated with at least a first dose of a non-mRNA vaccine.
But Mr Nafilyan said the context in which those jabs were given and to whom needed to be considered.
'Vaccination with the main non-mRNA vaccine used in the UK was stopped for young people following safety concerns in April 2021,' he said.
'And most of the young people who received it would have been prioritised due to clinical vulnerability or being healthcare workers.
'Therefore, these results cannot be generalised to the population as a whole.
'Whilst vaccination carries some risks, these need to be assessed in light of its benefits.'
The ONS analysis did not speculate why women seemed to be at greater risk of cardiac death following their first non-mRNA Covid jab compared to men.
While the data did record men had an estimated 1.18 increased risk of cardiac death following their first non-mRNA Covid jab, the ONS said the evidence wasn't strong enough to establish a link as these few deaths could just be down to chance.
It should also be noted that because young people's general chance of a cardiac death is so small in the first place, any increase can seem dramatic.
The ONS analysis also included data on risk of death following a positive Covid test for both jabbed and unjabbed young people.
Those without a Covid vaccine had a 2.5 times higher risk of death from any cause, whilst, in comparison, those who were jabbed had only a 1.9 times higher risk of dying.
The ONS did not analyse cardiac deaths specifically among people vaccinated who tested positive due to 'insufficient data'.
Other studies have shown that Covid vaccines greatly decrease the risk of hospitalisation and death among the general population, particularly for those most at risk, such as the elderly.
As a whole the study tears apart major claims peddled by anti-vaxxers who have wrongly said people who got the mRNA Covid vaccines are dying in droves.
However, a limitation of the study is that some deaths that have occurred in the period analysed might not be included due to ongoing investigations by a coroner.
Professor Adam Finn, an expert in paediatrics at University of Bristol, said the ONS study, 'raised as many questions as answers'.
'The findings are somewhat unexpected, as concerns about rare cardiac side-effects – specifically myocarditis and pericarditis – have hitherto been particularly associated with mRNA vaccine second doses in males especially when the dose interval was short, whereas the signal reported here is primarily in non-mRNA first doses in females,' he said.
A 2022 study led by academics at Imperial College London suggests almost 20million lives were saved by Covid vaccines in the first year since countries began rolling out the jabs, the majority in wealthy nations
However, he said the data also showing the risk disappeared for the second dose was 'reassuring'.
Professor Finn, a member of the UK's vaccine advisory the Joint Committee on Vaccination and Immunisation (JCVI), said in the end more detail on the cardiac deaths reported was needed.
'The next and most pressing issue that needs to be addressed is to gather more detailed information on what the nature of the reported cardiac events actually was, as this would help us begin to understand what is really being seen in these figures and might help guide future policy and vaccine design,' he said.
While AstraZeneca's jab was pulled specifically for young people in April in 2021 it has been effectively withdrawn in the UK with the Government not ordering any more doses.
This was based on advice from the JCVI which has not listed AstraZeneca in their recommended jab list for booster campaigns.
There are currently two non-mRNA Covid jabs approved for use in the UK.
These are the Novavax and Sanofi/GSK jab.
UK drug watchdog the Medicines and Healthcare products Regulatory Agency (MHRA) hasn't had any safety reports about the Sanofi/GSK jab with it only being approved for use in December last year.
Novavax was approved in February last year and was deployed 1,200 times during the autumn booster campaign, with 57 safety reports.
The ONS said they would continue to monitor data on Covid vaccines outcomes in the future.
.
Zoner
Veteran Member
This virus is a bio weapon for sure. Thanks for transcribing HD.
View: https://twitter.com/p_mcculloughmd/status/1640311582646321152?s=46&t=qtJegGIoLNbZqJYOm7N3mA
Zoner
Veteran Member
Here is the sub-stack article:
Quote: "I disagree with [Sasha Latypova’s] conclusion that the injuries and deaths resulting from the lack of regulatory oversight are intentional murder by a cabal of omnipotent “globalist central bankers” whose aim is to depopulate the planet."
A clarification on my part is required, because I believe my position has been inadvertently mischaracterized. (in the quote above.)
This does not describe my position or research focus correctly. The cabal of central bank private OWNERS (not the same as banks themselves) being behind the “covid pandemic” is only an educated guess on my part.
My research has been focused less on the ultimate ownership structure and much more on the executive organizational structure of the covid crime, which is not fuzzy at all.
I am writing about the cartel’s funding, manufacturing base, distribution, its dealers and enforcers and those who directly implement murder/manslaughter. I don’t have the name of the Godfather or his/her consiglieri.
I am studying the crime scene around me, which looks like this:
We have a mass murder/mass injury event ongoing and bodies are piling up. The deaths and injury are the result of the forced injections of “health products” that do not comply with any regulations for pharmaceuticals nor the lists of ingredients or advertised chemical composition. Thus they should be deemed de-facto poison.
Even if the manufacturers managed to produce these substances with fidelity to the label and the law, the products would be still extremely dangerous to administer on a mass scale due to numerous toxicities built into their design, which is perfectly well known to the regulators and manufacturers.
Albeit, the latter got rid of employees with expertise and conscience to know this in the years immediately preceding “covid success”, and replaced them with diversity hires and software.
The needles are in the hands of “nice people from healthcare” who are doing their jobs as commanded by their superiors. I am tracing this organization back, starting from the weapon of murder and assault - the needle.
Here is the clarification of my position:
- The mass injuries and deaths by the mRNA/DNA injections are intentional. They should be investigated as a crime of mass murder and attempted mass murder by poisoning.
- The lack of any enforcement action by HHS on the injuries and deaths is also intentional. This is demonstrated by the now very obvious refusal of the officialdom to stop them or limit in any way, despite clear evidence of their harm.
- HHS is following the orders of the National Security Council and the DOD as the Chief Operating Officer of the Operation Warp Speed, i.e. the HHS is operating under the military command structure. Debbie Lerman has identified NSC in charge of covid policy in her past writing, and I am grateful to her for pointing me in that direction.
- The organizational structure that is responsible for the execution of this crime in the US can be described as follows: POTUS=>NSC=>DOD=>HHS=>state and local health authorities => owners/administrators of health delivery settings=>local vaccinators.
- All men and women in positions of authority in the above organizational structure operate treasonously and under the color of law.
- What organization is above the treasonous US officials, I can only guess. I do not believe it’s the “market forces” of investors wanting returns and new marvelous tech of the “mRNA platform”. I have familiarity with both, market forces, and with central command-control structures and I am convinced that there is a centralized global control of this operation due to the perfectly implemented global lockstep procedures and control of ALL governments. The US alone cannot do this.
- The DOD is in charge of funding and ordering the injections from complicit pharmaceutical manufacturers, bypassing pharmaceutical regulations, and utilizing opaque defense purchasing systems typically used for weapons manufacture. DOD is in charge of the distribution of injections to the intended targets - the people of the United States. The intended targets also include military service members, government workers and even expendable employees of the pharma companies.
- The pseudo-legal statutory framework that the treasonous men and women are utilizing to commit these crimes has been described in detail by Katherine Watt.
naegling62
Veteran Member
Wow! Page #1686 link saved and will read thoroughly later.
Zoner
Veteran Member
So Dowd is right here.
"The excess deaths are now exceeding 2020. The disabilities are well above 2020. So what do we have now? We have a pandemic! These are pandemic numbers that we're not talking about. This is actually a pandemic of the vaccinated. Full stop." — @DowdEdward
There is currently a pandemic....of those who have been vaccinated. And it's about all the deaths and injuries coming from the vaccines ... not Covid!
View: https://twitter.com/ZombyWoof2022/status/1640472315900166144?s=20
"The excess deaths are now exceeding 2020. The disabilities are well above 2020. So what do we have now? We have a pandemic! These are pandemic numbers that we're not talking about. This is actually a pandemic of the vaccinated. Full stop." — @DowdEdward
There is currently a pandemic....of those who have been vaccinated. And it's about all the deaths and injuries coming from the vaccines ... not Covid!
View: https://twitter.com/ZombyWoof2022/status/1640472315900166144?s=20
Zoner
Veteran Member
View: https://twitter.com/zombywoof2022/status/1637155560410734594?s=46&t=OPE0T1OQsHivoz1auQUcBQHere is the sub-stack article:
Quote: "I disagree with [Sasha Latypova’s] conclusion that the injuries and deaths resulting from the lack of regulatory oversight are intentional murder by a cabal of omnipotent “globalist central bankers” whose aim is to depopulate the planet."
A clarification on my part is required, because I believe my position has been inadvertently mischaracterized. (in the quote above.)
This does not describe my position or research focus correctly. The cabal of central bank private OWNERS (not the same as banks themselves) being behind the “covid pandemic” is only an educated guess on my part.
My research has been focused less on the ultimate ownership structure and much more on the executive organizational structure of the covid crime, which is not fuzzy at all.
I am writing about the cartel’s funding, manufacturing base, distribution, its dealers and enforcers and those who directly implement murder/manslaughter. I don’t have the name of the Godfather or his/her consiglieri.
I am studying the crime scene around me, which looks like this:
We have a mass murder/mass injury event ongoing and bodies are piling up. The deaths and injury are the result of the forced injections of “health products” that do not comply with any regulations for pharmaceuticals nor the lists of ingredients or advertised chemical composition. Thus they should be deemed de-facto poison.
Even if the manufacturers managed to produce these substances with fidelity to the label and the law, the products would be still extremely dangerous to administer on a mass scale due to numerous toxicities built into their design, which is perfectly well known to the regulators and manufacturers.
Albeit, the latter got rid of employees with expertise and conscience to know this in the years immediately preceding “covid success”, and replaced them with diversity hires and software.
The needles are in the hands of “nice people from healthcare” who are doing their jobs as commanded by their superiors. I am tracing this organization back, starting from the weapon of murder and assault - the needle.
Here is the clarification of my position:
- The mass injuries and deaths by the mRNA/DNA injections are intentional. They should be investigated as a crime of mass murder and attempted mass murder by poisoning.
- The lack of any enforcement action by HHS on the injuries and deaths is also intentional. This is demonstrated by the now very obvious refusal of the officialdom to stop them or limit in any way, despite clear evidence of their harm.
- HHS is following the orders of the National Security Council and the DOD as the Chief Operating Officer of the Operation Warp Speed, i.e. the HHS is operating under the military command structure. Debbie Lerman has identified NSC in charge of covid policy in her past writing, and I am grateful to her for pointing me in that direction.
- The organizational structure that is responsible for the execution of this crime in the US can be described as follows: POTUS=>NSC=>DOD=>HHS=>state and local health authorities => owners/administrators of health delivery settings=>local vaccinators.
- All men and women in positions of authority in the above organizational structure operate treasonously and under the color of law.
- What organization is above the treasonous US officials, I can only guess. I do not believe it’s the “market forces” of investors wanting returns and new marvelous tech of the “mRNA platform”. I have familiarity with both, market forces, and with central command-control structures and I am convinced that there is a centralized global control of this operation due to the perfectly implemented global lockstep procedures and control of ALL governments. The US alone cannot do this.
- The DOD is in charge of funding and ordering the injections from complicit pharmaceutical manufacturers, bypassing pharmaceutical regulations, and utilizing opaque defense purchasing systems typically used for weapons manufacture. DOD is in charge of the distribution of injections to the intended targets - the people of the United States. The intended targets also include military service members, government workers and even expendable employees of the pharma companies.
- The pseudo-legal statutory framework that the treasonous men and women are utilizing to commit these crimes has been described in detail by Katherine Watt.
Heliobas Disciple
TB Fanatic
Brazil hits 700,000 virus deaths, 2nd highest in the world
SAO PAULO (AP) — Brazil's government on Tuesday reported the 700,000th death from COVID-19 in the South American nation, which has the second most victims of the virus after the United States. Brazilian health experts say most people dying of COVID-19 in recent days are either unvaccinated or...
apnews.com
Brazil hits 700,000 virus deaths, 2nd highest in the world
By MAURICIO SAVARESE
yesterday
SAO PAULO (AP) — Brazil’s government on Tuesday reported the 700,000th death from COVID-19 in the South American nation, which has the second most victims of the virus after the United States.
Brazilian health experts say most people dying of COVID-19 in recent days are either unvaccinated or suffer from other debilitating diseases.
“The vaccine currently available in every health care unit in Brazil could have changed the lives of families who lost beloved ones in the pandemic,” said the country’s Health Ministry
Health Minister Nisia Trindade criticized former President Jair Bolsonaro for his handling of the pandemic. Bolsonaro, who became ill with COVID, later declined to take the coronavirus vaccine and flouted health restrictions.
“We have to look at the past, but at the same time we have to say the health ministry cannot make the mistake of not coordinating, not taking care, not treating (the disease). We need to be united so new tragedies do not happen,” Trindade said.
Miguel Lago, executive director of Brazil’s Institute for Health Policy Studies, which advises public health officials, said the figure is a reminder of the country’s obligation to punish those who failed to act against the virus or sabotaged those who were trying.
“There was direct responsibility of public agents, who could have answered to this in a much better fashion,” Lago told The Associated Press.
Heliobas Disciple
TB Fanatic
Game-Changer Nasal Spray: A Universal Shield Against All COVID-19 Variants
Researchers have developed a molecule that is, when administered nasally, extremely effective in preventing the disease caused by all known variants of SARS-CoV-2, the virus that causes COVID-19. The molecule can be a key tool in preparing for future pandemics, as it is aimed at preventing both the
scitechdaily.com
Game-Changer Nasal Spray: A Universal Shield Against All COVID-19 Variants
By University of Helsinki
March 28, 2023
Researchers have developed a molecule that is, when administered nasally, extremely effective in preventing the disease caused by all known variants of SARS-CoV-2, the virus that causes COVID-19. The molecule can be a key tool in preparing for future pandemics, as it is aimed at preventing both the transmission and spread of the virus.
In laboratory animal studies, a molecule known as TriSb92, developed by researchers at the University of Helsinki, has been confirmed as affording effective protection against coronavirus infection. The molecule identifies a region in the spike protein of the coronavirus common to all current variants of the virus and inhibits its functioning.
“When administered nasally, the TriSb92 molecule is extremely effective in preventing infection, and experiments carried out in cell cultures indicate that it also encompasses the very latest variants, including XBB, BF7, and BQ.1.1,” explains Postdoctoral Researcher Anna R. Mäkelä from Professor Kalle Saksela’s research group.
Animal models have also demonstrated that, unlike face masks, the molecule can, when sprayed into the nose, prevent infection even after a few hours of exposure.
According to the researchers, the molecule remains fully functional at room temperature for at least 18 months, making it well-suited for use as a nasal spray.
The results were published on March 24 in the Nature Communications journal.
Anticipation of future viral variants
While the worst stage of the coronavirus pandemic is, at least for the time being, behind us, nasally administered protection can be a crucial help in preventing the spread of the virus in the future.
“The latest variants effectively avoid the immune protection provided by both vaccines and the COVID-19 disease, and current vaccines are not effective in preventing transmission,” Mäkelä says.
Moreover, the nasal spray can protect those people from serious disease who do not gain sufficient immunity from vaccines, such as immunocompromised individuals and elderly.
According to the researchers, the molecule could also work against future animal-borne close relatives of SARS-CoV-2, which are expected to be the cause of entirely new coronavirus pandemics.
“Since the region in the coronavirus’s spike protein affected by the TriSb92 molecule has remained almost unchanged in all viral variants so far emerged, it can be assumed to be effective also against future SARS-CoV-2 variants,” Mäkelä confirms.
“The easily and inexpensively produced TriSb92 could be a very important first line of defense in curbing such a new pandemic, pending the development, production, and distribution of vaccines,” she adds.
A copyable approach
According to the researchers, the sherpabody-technology used is also applicable to the prevention of many other viral diseases, particularly influenza, and other respiratory viruses.
“The whole approach stems from a technical solution based on a binder protein platform developed in Finland, which was not originally intended for the development of an antiviral drug. It provides an opportunity for many other new initiatives based on the accurate identification of diseased cells or pathogens in patients,” Mäkelä says.
In the next stage, the molecule must be tested in clinical trials, after which it could be made commercially available.
“Successful commercialization of the nasal spray could lead to the creation of a thriving Finnish business,” Mäkelä points out.
Reference: “Intranasal trimeric sherpabody inhibits SARS-CoV-2 including recent immunoevasive Omicron subvariants” by Anna R. Mäkelä, Hasan Uğurlu, Liina Hannula, Ravi Kant, Petja Salminen, Riku Fagerlund, Sanna Mäki, Anu Haveri, Tomas Strandin, Lauri Kareinen, Jussi Hepojoki, Suvi Kuivanen, Lev Levanov, Arja Pasternack, Rauno A. Naves, Olli Ritvos, Pamela Österlund, Tarja Sironen, Olli Vapalahti, Anja Kipar, Juha T. Huiskonen, Ilona Rissanen and Kalle Saksela, 24 March 2023, Nature Communications.
DOI: 10.1038/s41467-023-37290-6
Heliobas Disciple
TB Fanatic
After listening to Geert for so many months, and after some studies we posted here about some weird hyper immune response (I'll have to search the thread which isn't going to be easy because i don't remember what immune response it was so don't have a search term. Does anyone remember what I'm talking about***?), I'm guessing there is more to this study and that we really need Geert or Igor's evaluation of it. I wonder what the t cells of the unvaccinated would be if they were exposed to covid again, and not just recovering for 4 months. You would think it would go down if they were getting better and the elevated t cells if you're no longer sick may not be such a good thing... (?????). Although I vaguely remember Geert saying the vaccinees had elevated t cells which for now was protecting them from all kinds of diseases, I think he said it around the time the monkeypox outbreak was going on. One more thing to note - this study was done in 2021 - long before Omicron, which changed things dramatically according to Geert's last few videos.
Thailand Medical News also reported on t cells tonight too so I'll post that next.
*** I found it - those articles had to do with the IG4 response, not t cells but somehow this has to fit together. I hope Igor does a substack about this new paper and makes sense of it for us.
igorchudov.substack.com
and here are the posts on this thread, click on the post number and it should take you there:
posts #66,473, #66,514 , #66,870, #66,882
~~~~~~~~~~~~~~~~~~~~~~~~~~~~
news.yahoo.com
(fair use applies)
Getting COVID-19 Could Weaken Your Immune System
Alice Park - TIME
Mon, March 27, 2023, 10:37 AM EDT
Even relatively easy bouts with COVID-19 can still take a toll on the immune system, according to a paper published Mar. 15 in the journal Immunity—particularly on T-cells, which provide long term and durable protection against viruses.
Mark Davis, a professor of immunology at Stanford University and director of the Stanford Institute for Immunity, Transplantation, and Infection, and his team made the discovery when studying T cell responses to SARS-CoV-2 among 72 people through the early months of 2021, as the first COVID-19 vaccines were becoming available. They used the most sensitive method available to track changes in T cell responses, relying on an engineered molecule that can detect up to five-fold more T cells targeting SARS-CoV-2 than other molecules. The researchers focused on three groups of people: those who were not yet vaccinated and had gotten COVID-19, those who were fully vaccinated with two doses of the Pfizer-BioNTech mRNA vaccine and had not been infected, and people who had gotten vaccinated after recovering from COVID-19.
The researchers looked at a group of T cells called CD8 cells, or killer T cells, which destroy and remove infected cells during the latter part of an infection. Davis was surprised to find that levels of CD8 cells were lower among people who had gotten vaccinated after recovering from COVID-19, compared to those who had been vaccinated and never infected. The results differ from changes in antibodies, which are the body’s first line of defense and help block viruses from infecting cells. Studies of COVID-19 patients show that antibody levels in people who have been vaccinated and infected tend to be slightly higher than levels of antibodies among those who have been vaccinated and never been infected—creating hybrid immunity. The opposite was true with CD8 cells. “Sometimes you do experiments and don’t always know what you’re going to get, and something jumps out at you, and that was the case here,” Davis says. The fact that they saw “dramatically lower CD8 or killer T cell responses than everyone else” indicated that “there was some damage—something was happening after the infection in these people.”
Because researchers took multiple blood samples from the volunteers over the four-month study, they were able to delve deeper in how the T cell populations were changing, and confirmed the pattern. Vaccinated people who had not had COVID-19 generated CD8 T cells up to 67.1-times higher than they did before they got the shots. While people who had recovered from COVID-19 and then got vaccinated also produced higher levels compared to baseline, these were anywhere from 3.6- to 54-times lower than the levels generated by the first group. “It turns out the virus suppresses CD8 responses,” says Davis. “It could be making it more difficult for CD8 cell populations to come back up again.”
“The message is that with this disease, we are not completely out of the woods yet when the virus is gone,” says Davis. “We generally think in terms of the T cell response that more is better, so what we saw in the reduction in the number of cells can’t be good.”
Researchers don’t yet know what a weaker CD8 response against SARS-CoV-2 means for a person’s health. But the study also showed that people in this group still benefited from the vaccine—just not as much as those who hadn’t been infected before getting it. Levels of CD8 cells among those who had infections and then were vaccinated were still higher than levels among unvaccinated people.
The results raise the question of whether the apparent damage to CD8 T cell production might contribute to a greater risk of Long COVID, but more data are needed to explore that possibility. “There can be lasting damage that might be resulting in something like Long COVID, or it might be something else,” says Davis. “We don’t know yet.”
Given these findings, can repeated COVID-19 infections continue to dampen the T cell response, and increase the likelihood of Long COVID or worsening symptoms? It’s possible, since experts believe that the T cell response is responsible for the more durable protection that keeps people from experiencing severe disease resulting in hospitalization or death. But that question, too, remains unanswered.
These results, which shed light on how T cell immunity responds to natural infections and vaccines, should play a role in ongoing discussions about booster shots, says Davis. Another key will be studying whether the same pattern is found with other types of COVID-19 vaccines that don’t rely on mRNA. He and his team also looked at CD4 T cells, or helper T cells, which work with antibodies soon after infection to block as many viruses from infecting cells as possible. They found that, unlike with other vaccines against viruses, the CD4 and CD8 T cell responses are not synchronous after immunization. Normally, both populations of cells rapidly increase in response to a vaccine, but after the Pfizer-BioNTech shot, levels of CD4 cells rose first, while CD8 cells didn’t peak until two weeks later. Davis suspects that may be related to the mRNA vaccine formulation and the way the mRNA shots present the viral targets to the immune system.
“We hope that with this study, people will look at some of the more recent vaccine formulations, not just mRNA,” he says, to gain more knowledge about which formulation might produce the strongest T cell response. As more and more people get infected, “the best impact of this would be to stimulate further investigations to see if we can boost those CD8 T cells.”
Thailand Medical News also reported on t cells tonight too so I'll post that next.
*** I found it - those articles had to do with the IG4 response, not t cells but somehow this has to fit together. I hope Igor does a substack about this new paper and makes sense of it for us.
Booster-Caused IgG4 Immune Tolerance Explains Excess Mortality and "Chronic Covid"
Perhaps Giving Unproven Vaccines to Billions was a Bad Idea, After All
igorchudov.substack.com
and here are the posts on this thread, click on the post number and it should take you there:
posts #66,473, #66,514 , #66,870, #66,882
~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Getting COVID-19 Could Weaken Your Immune System
A study illustrates how SARS-CoV-2 can damage your immune response.
Getting COVID-19 Could Weaken Your Immune System
Alice Park - TIME
Mon, March 27, 2023, 10:37 AM EDT
Even relatively easy bouts with COVID-19 can still take a toll on the immune system, according to a paper published Mar. 15 in the journal Immunity—particularly on T-cells, which provide long term and durable protection against viruses.
Mark Davis, a professor of immunology at Stanford University and director of the Stanford Institute for Immunity, Transplantation, and Infection, and his team made the discovery when studying T cell responses to SARS-CoV-2 among 72 people through the early months of 2021, as the first COVID-19 vaccines were becoming available. They used the most sensitive method available to track changes in T cell responses, relying on an engineered molecule that can detect up to five-fold more T cells targeting SARS-CoV-2 than other molecules. The researchers focused on three groups of people: those who were not yet vaccinated and had gotten COVID-19, those who were fully vaccinated with two doses of the Pfizer-BioNTech mRNA vaccine and had not been infected, and people who had gotten vaccinated after recovering from COVID-19.
The researchers looked at a group of T cells called CD8 cells, or killer T cells, which destroy and remove infected cells during the latter part of an infection. Davis was surprised to find that levels of CD8 cells were lower among people who had gotten vaccinated after recovering from COVID-19, compared to those who had been vaccinated and never infected. The results differ from changes in antibodies, which are the body’s first line of defense and help block viruses from infecting cells. Studies of COVID-19 patients show that antibody levels in people who have been vaccinated and infected tend to be slightly higher than levels of antibodies among those who have been vaccinated and never been infected—creating hybrid immunity. The opposite was true with CD8 cells. “Sometimes you do experiments and don’t always know what you’re going to get, and something jumps out at you, and that was the case here,” Davis says. The fact that they saw “dramatically lower CD8 or killer T cell responses than everyone else” indicated that “there was some damage—something was happening after the infection in these people.”
Because researchers took multiple blood samples from the volunteers over the four-month study, they were able to delve deeper in how the T cell populations were changing, and confirmed the pattern. Vaccinated people who had not had COVID-19 generated CD8 T cells up to 67.1-times higher than they did before they got the shots. While people who had recovered from COVID-19 and then got vaccinated also produced higher levels compared to baseline, these were anywhere from 3.6- to 54-times lower than the levels generated by the first group. “It turns out the virus suppresses CD8 responses,” says Davis. “It could be making it more difficult for CD8 cell populations to come back up again.”
“The message is that with this disease, we are not completely out of the woods yet when the virus is gone,” says Davis. “We generally think in terms of the T cell response that more is better, so what we saw in the reduction in the number of cells can’t be good.”
Researchers don’t yet know what a weaker CD8 response against SARS-CoV-2 means for a person’s health. But the study also showed that people in this group still benefited from the vaccine—just not as much as those who hadn’t been infected before getting it. Levels of CD8 cells among those who had infections and then were vaccinated were still higher than levels among unvaccinated people.
The results raise the question of whether the apparent damage to CD8 T cell production might contribute to a greater risk of Long COVID, but more data are needed to explore that possibility. “There can be lasting damage that might be resulting in something like Long COVID, or it might be something else,” says Davis. “We don’t know yet.”
Given these findings, can repeated COVID-19 infections continue to dampen the T cell response, and increase the likelihood of Long COVID or worsening symptoms? It’s possible, since experts believe that the T cell response is responsible for the more durable protection that keeps people from experiencing severe disease resulting in hospitalization or death. But that question, too, remains unanswered.
These results, which shed light on how T cell immunity responds to natural infections and vaccines, should play a role in ongoing discussions about booster shots, says Davis. Another key will be studying whether the same pattern is found with other types of COVID-19 vaccines that don’t rely on mRNA. He and his team also looked at CD4 T cells, or helper T cells, which work with antibodies soon after infection to block as many viruses from infecting cells as possible. They found that, unlike with other vaccines against viruses, the CD4 and CD8 T cell responses are not synchronous after immunization. Normally, both populations of cells rapidly increase in response to a vaccine, but after the Pfizer-BioNTech shot, levels of CD4 cells rose first, while CD8 cells didn’t peak until two weeks later. Davis suspects that may be related to the mRNA vaccine formulation and the way the mRNA shots present the viral targets to the immune system.
“We hope that with this study, people will look at some of the more recent vaccine formulations, not just mRNA,” he says, to gain more knowledge about which formulation might produce the strongest T cell response. As more and more people get infected, “the best impact of this would be to stimulate further investigations to see if we can boost those CD8 T cells.”
Last edited:
Heliobas Disciple
TB Fanatic
COVID-19 News: Is SARS-CoV-2 Evolving To Evade T-Cell Immunity And Also Destroy T Cells With The Debut Of XBB.1.16, EG.1, EU.1.1 And FD.1.1 Variants? - Thailand Medical News
COVID-19 News: In the course of the COVID-19 pandemic, we have seen the SARS-CoV-2 virus constantly evolving and spawning newer variants and sub-lineages and, in some cases, even recombining to evade the various antibodies induced by the vaccines or even by the previous infections. The various...
www.thailandmedical.news
COVID-19 News: Is SARS-CoV-2 Evolving To Evade T-Cell Immunity And Also Destroy T Cells With The Debut Of XBB.1.16, EG.1, EU.1.1 And FD.1.1 Variants?
Thailand Medical News
March 29 2023, 3 hrs ago
In the course of the COVID-19 pandemic, we have seen the SARS-CoV-2 virus constantly evolving and spawning newer variants and sub-lineages and, in some cases, even recombining to evade the various antibodies induced by the vaccines or even by the previous infections. The various monoclonal based therapeutics and convalescent plasma protocols are no longer effective to deal with the current range of variants and sub-lineages causing the ongoing COVID-19 onslaughts.
The SARS-CoV-02 virus has even evolved to create drug resistant strains via mutations that can cause the various antivirals like remdesivir, paxlovid and molnupiravir to become ineffective.
Already we have seen through numerous past studies that the SARS-CoV-2 is not only disrupting and stopping both innate and adaptive immune responses so that it can evade their inhibitory effects, but it some cases it also causes the damage of various important components of the human immune system, making many to suffer from a dysfunctional immune system or worse in some cases to suffer from COVID-19 induced immunodeficiency.
(Note; Supporting studies for everything mentioned above can be found in the Thailand Medical news repository of SARS-CoV-2 studies…use the TMN search function.)
However, what is now concerning researchers, scientists and healthcare professionals is whether or not the SARS-CoV-2 virus is now continuing to find ways to not only totally evade the T-Cell immune responses but also destroy or damage the T Cells even more effectively.
Considering the integral role of T cells in SARS-CoV-2 immunity, the potential exists for selective pressure to lead to T cell escape, although the extent to which SARS-CoV-2 mutations affect T cells is currently poorly understood.
Functional T cell responses are directed against multiple virus proteins, with the magnitude of response correlating with viral protein expression levels. Responses to spike protein, N protein and M protein dominate, with appreciable responses also seen against ORF3a and the non-structural proteins NSP3 and NSP12.
Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases - PubMed
T cells are involved in control of SARS-CoV-2 infection. To establish the patterns of immunodominance of different SARS-CoV-2 antigens and precisely measure virus-specific CD4<sup>+</sup> and CD8<sup>+</sup> T cells, we study epitope-specific T cell responses of 99 convalescent coronavirus...
pubmed.ncbi.nlm.nih.gov
As the T cell response targets epitopes across the SARS-CoV-2 genome, the footprints of T cell escape are more broadly distributed than antibody-driven changes, which are concentrated within dominant epitopes of the spike protein.
Few studies have documented intrahost evolution within T cell epitopes, which would serve as direct evidence of T cell escape. Mutations within CD8+ epitopes in N protein (M322I and L331F), M protein (L90F) and the spike protein (L270F) were noted within minority variants in one study during the course of acute infections, resulting in loss of epitope-specific responses.
SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses - PubMed
CD8<sup>+</sup> T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control. Here, we identified nonsynonymous mutations in MHC-I-restricted CD8<sup>+</sup> T cell epitopes after deep sequencing of 747 SARS-CoV-2 virus isolates. Mutant peptides exhibited diminished...
pubmed.ncbi.nlm.nih.gov
Interestingly, prolonged SARS-CoV-2 infections in immunocompromised hosts may offer greater opportunities for T cell escape, akin to the extensively described examples in HIV-1 infection.
The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection - PubMed
Identification of the transmitted/founder virus makes possible, for the first time, a genome-wide analysis of host immune responses against the infecting HIV-1 proteome. A complete dissection was made of the primary HIV-1-specific T cell response induced in three acutely infected patients...
pubmed.ncbi.nlm.nih.gov
The emergence of the NSP3 T504P mutation resulting in loss of a CD8+ epitope response has been reported in multiple individuals with impaired humoral immune deficiency but preserved T cell responses in the context of chronic SARS-CoV-2 infection113,114.
Recurrent SARS-CoV-2 mutations in immunodeficient patients - PubMed
Long-term severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in immunodeficient patients are an important source of variation for the virus but are understudied. Many case studies have been published which describe one or a small number of long-term infected individuals but...
pubmed.ncbi.nlm.nih.gov
SARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19
Evolution of SARS-CoV-2 in immunocompromised hosts may result in novel variants with changed properties, but the mode of selection underlying this process remains unclear. While escape from humoral immunity certainly plays a role in intra-host evolution, escape from cellular immunity is poorly un...
www.researchsquare.com
Although these findings are limited to a few cases, there is an urgent need for more prospective cohort studies systematically evaluating the risk of T cell escape in certain patient populations and with newer emerging sub-lineages.
More details for the answers to these questions can perhaps be found in more comprehensive studies involving the newer SARS-CoV-2 sub-lineages that have emerged including the XBB.1.16, EG.1(XBB.1.9.2.1), EU.1.1(XBB.1.5.26.1.1), FD.1.1 (XBB.1.5.15.1.1) and even the CH.1.1.12.
From a preliminary perspective, most of these new sub-lineages are now having more emphasis on mutations in the N proteins and not spike mutations and are using various mutations on the various ORF proteins that are involved with silencing or disrupting immune responses to achieve its goal of further evading any last left T Cell immunity responses and also damaging them so that it can help when the next line of sub-lineages emerges for the ‘great kill’!
The XBB.1.16 aka Arcturus for instance is a lineage with 5 additional mutations E180V, K478R, and S486P, ORF9b:I5T and ORF9b:N55S. XBB.1.5 doesn’t have these mutations in ORFb.
Studies and COVID-19 News coverages have already shown that the mutations in ORF9b assists with innate immunosuppression.
SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO - PubMed
Coronavirus disease 2019 (COVID-19) is a current global health threat caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Emerging evidence indicates that SARS-CoV-2 elicits a dysregulated immune response and a delayed interferon (IFN) expression in...
pubmed.ncbi.nlm.nih.gov
SARS-CoV-2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG-I/MDA-5-MAVS, TLR3-TRIF, and cGAS-STING signaling pathways - PubMed
The suppression of types I and III interferon (IFN) responses by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contributes to the pathogenesis of coronavirus disease 2019 (COVID-19). The strategy used by SARS-CoV-2 to evade antiviral immunity needs further investigation. Here, we...
pubmed.ncbi.nlm.nih.gov
Shandong University Study Uncovers That SARS-CoV-2 ORF9b Antagonizes Type I and III Interferons By Targeting Components Of Signaling Pathways! - Thailand Medical News
SARS-CoV-2 Research: Chinese scientist from Shandong University in Jinan-China have discovered that the SARS-CoV-2 ORF9b proteins are able to inhibit type I and III interferon (IFN) response and production by targeting various components of various immune signaling pathways. The study...
www.thailandmedical.news
BREAKING! COVID-19 Research: Coronavirus Study Reveals That SARS-CoV-2 Orf9b Protein Binds To Human Host Mitochondria Protein Tom70 - Thailand Medical News
COVID-19 Research: A new international comparison study of the various coronaviruses and their effects on human host proteins and various human cellular pathways have revealed among many findings that the SARS-CoV-2 coronavirus protein Orf9b actually binds with the human host mitochondria...
www.thailandmedical.news
The exact consequences of the mutations in this variant remain unclear; however, it is evident that both XBB.1 and XBB.1.5 have managed to elude antibodies generated from previous infections, the bivalent booster, and monoclonal antibody therapies. Consequently, our reliance on T-cells for protection has increased. For T-cells to effectively defend us, the virus must first infect a cell, which then triggers the T-cells to eliminate the virus-infected cell. This process inadvertently hastens cellular aging with each subsequent infection.
Viral infections that bypass antibodies can be highly damaging, as they infect various cell types, including immune cells. T-cells must eliminate virus-infected cells, which can lead to cell death and the need for uninfected cells to divide and restore the population. However, cells can only divide a limited number of times, with cellular aging indicated by the shortening of telomeres. Women tend to produce more naive T-cells and have longer telomeres, which may contribute to their longer lifespans compared to men. Telomere shortening affects tissue regeneration and homeostasis, and continuous immune reactions can lead to replicative senescence.
Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 Survivors
The SARS-CoV-2 infection determines the COVID-19 syndrome characterized, in the worst cases, by severe respiratory distress, pulmonary and cardiac fibrosis, inflammatory cytokine release, and immunosuppression. This condition has led to the death of about 2.15% of the total infected world...
www.mdpi.com
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835063/’
There is a very high possibility that XBB.1.16 and the rest of the newer SARS-CoV-2 sub-lineages ie EG.1, EU.1.1, FD.1.1, and CH.1.1.12 may be more capable of evading T-cells, the last line of defense for our immune system via using mutations o their various N proteins or ORF proteins.
Initial findings indicate that XBB.1.16 seems to be increasingly adept at disrupting the communication between infected cells and T-cells, making it harder for T-cells to identify and target infected cells. In essence, this means T-cells may struggle to detect infected cells. If T-cells fail to recognize more infected cells, it allows COVID to replicate, spread, and persist in regions inaccessible to T-cells.
If this scenario unfolds, a larger number of individuals will have difficulty eliminating the virus, leading to increased infections, persistent inflammation, and related autoimmune disorders, as well as musculoskeletal, neurological, cognitive, and vascular dysfunction.
As more emerging sub-lineages evolve to better suppress or infect T-cells, the overall impact on the global communal physical, mental, and economic well-being will be substantial.
The pandemic is far from over. COVID is continuously mutating to outcompete other variants and possesses a high rate of evolution. Contrary to popular hopes, it has not stabilized and is evolving more rapidly than before, providing it with countless opportunities to find a more effective method of transmission. Once a variant succeeds, it can spread to nearly every country on Earth within weeks to months.
Already in India, statistical data shows that XBB.1.16 has caused a 205% increase in cases and a 400% increase in deaths in India over the past 14 days.
The coming weeks will show what the XBB.1.16, EG.1, EU.1.1, FD.1.1, and CH.1.1.12 sub-lineages will be causing in various geolocations across the world.
Urgent studies are needed in the meanwhile to assess if the SARS-CoV-2 virus is indeed evolving to completely evade T cell immunity and also to damage or destroy the T Cells.
.
Zoner
Veteran Member
Way out of my pay grade HD, but keep at it. I think you're right on their heels.After listening to Geert for so many months, and after some studies we posted here about some weird hyper immune response (I'll have to search the thread which isn't going to be easy because i don't remember what immune response it was so don't have a search term. Does anyone remember what I'm talking about***?), I'm guessing there is more to this study and that we really need Geert or Igor's evaluation of it. I wonder what the t cells of the unvaccinated would be if they were exposed to covid again, and not just recovering for 4 months. You would think it would go down if they were getting better and the elevated t cells if you're no longer sick may not be such a good thing... (?????). Although I vaguely remember Geert saying the vaccinees had elevated t cells which for now was protecting them from all kinds of diseases, I think he said it around the time the monkeypox outbreak was going on. One more thing to note - this study was done in 2021 - long before Omicron, which changed things dramatically according to Geert's last few videos.
Thailand Medical News also reported on t cells tonight too so I'll post that next.
*** I found it - those articles had to do with the IG4 response, not t cells but somehow this has to fit together. I hope Igor does a substack about this new paper and makes sense of it for us.
Booster-Caused IgG4 Immune Tolerance Explains Excess Mortality and "Chronic Covid"
Perhaps Giving Unproven Vaccines to Billions was a Bad Idea, After All
and here are the posts on this thread, click on the post number and it should take you there:
posts #66,473, #66,514 , #66,870, #66,882
~~~~~~~~~~~~~~~~~~~~~~~~~~~~
(fair use applies)Getting COVID-19 Could Weaken Your Immune System
A study illustrates how SARS-CoV-2 can damage your immune response.
Getting COVID-19 Could Weaken Your Immune System
Alice Park - TIME
Mon, March 27, 2023, 10:37 AM EDT
Even relatively easy bouts with COVID-19 can still take a toll on the immune system, according to a paper published Mar. 15 in the journal Immunity—particularly on T-cells, which provide long term and durable protection against viruses.
Mark Davis, a professor of immunology at Stanford University and director of the Stanford Institute for Immunity, Transplantation, and Infection, and his team made the discovery when studying T cell responses to SARS-CoV-2 among 72 people through the early months of 2021, as the first COVID-19 vaccines were becoming available. They used the most sensitive method available to track changes in T cell responses, relying on an engineered molecule that can detect up to five-fold more T cells targeting SARS-CoV-2 than other molecules. The researchers focused on three groups of people: those who were not yet vaccinated and had gotten COVID-19, those who were fully vaccinated with two doses of the Pfizer-BioNTech mRNA vaccine and had not been infected, and people who had gotten vaccinated after recovering from COVID-19.
The researchers looked at a group of T cells called CD8 cells, or killer T cells, which destroy and remove infected cells during the latter part of an infection. Davis was surprised to find that levels of CD8 cells were lower among people who had gotten vaccinated after recovering from COVID-19, compared to those who had been vaccinated and never infected. The results differ from changes in antibodies, which are the body’s first line of defense and help block viruses from infecting cells. Studies of COVID-19 patients show that antibody levels in people who have been vaccinated and infected tend to be slightly higher than levels of antibodies among those who have been vaccinated and never been infected—creating hybrid immunity. The opposite was true with CD8 cells. “Sometimes you do experiments and don’t always know what you’re going to get, and something jumps out at you, and that was the case here,” Davis says. The fact that they saw “dramatically lower CD8 or killer T cell responses than everyone else” indicated that “there was some damage—something was happening after the infection in these people.”
Because researchers took multiple blood samples from the volunteers over the four-month study, they were able to delve deeper in how the T cell populations were changing, and confirmed the pattern. Vaccinated people who had not had COVID-19 generated CD8 T cells up to 67.1-times higher than they did before they got the shots. While people who had recovered from COVID-19 and then got vaccinated also produced higher levels compared to baseline, these were anywhere from 3.6- to 54-times lower than the levels generated by the first group. “It turns out the virus suppresses CD8 responses,” says Davis. “It could be making it more difficult for CD8 cell populations to come back up again.”
“The message is that with this disease, we are not completely out of the woods yet when the virus is gone,” says Davis. “We generally think in terms of the T cell response that more is better, so what we saw in the reduction in the number of cells can’t be good.”
Researchers don’t yet know what a weaker CD8 response against SARS-CoV-2 means for a person’s health. But the study also showed that people in this group still benefited from the vaccine—just not as much as those who hadn’t been infected before getting it. Levels of CD8 cells among those who had infections and then were vaccinated were still higher than levels among unvaccinated people.
The results raise the question of whether the apparent damage to CD8 T cell production might contribute to a greater risk of Long COVID, but more data are needed to explore that possibility. “There can be lasting damage that might be resulting in something like Long COVID, or it might be something else,” says Davis. “We don’t know yet.”
Given these findings, can repeated COVID-19 infections continue to dampen the T cell response, and increase the likelihood of Long COVID or worsening symptoms? It’s possible, since experts believe that the T cell response is responsible for the more durable protection that keeps people from experiencing severe disease resulting in hospitalization or death. But that question, too, remains unanswered.
These results, which shed light on how T cell immunity responds to natural infections and vaccines, should play a role in ongoing discussions about booster shots, says Davis. Another key will be studying whether the same pattern is found with other types of COVID-19 vaccines that don’t rely on mRNA. He and his team also looked at CD4 T cells, or helper T cells, which work with antibodies soon after infection to block as many viruses from infecting cells as possible. They found that, unlike with other vaccines against viruses, the CD4 and CD8 T cell responses are not synchronous after immunization. Normally, both populations of cells rapidly increase in response to a vaccine, but after the Pfizer-BioNTech shot, levels of CD4 cells rose first, while CD8 cells didn’t peak until two weeks later. Davis suspects that may be related to the mRNA vaccine formulation and the way the mRNA shots present the viral targets to the immune system.
“We hope that with this study, people will look at some of the more recent vaccine formulations, not just mRNA,” he says, to gain more knowledge about which formulation might produce the strongest T cell response. As more and more people get infected, “the best impact of this would be to stimulate further investigations to see if we can boost those CD8 T cells.”
Even the experts like Geert are out there on the wild frontier. No one has been this way before. This is not a natural virus, this is a bio-weapon for cryin out loud. NOBODY knows where this is going or how it will end, not even those who manufactured it. We're in the end of days according to the Bible, so the best thing we can do is be at peace with God. I stay alert but I refuse to live in fear. The human race has never been this way before and darkness has descended. Evil is everywhere. I keep thinking of one thing Jesus said, "Unless those days were shortened, no flesh would be saved; but for the elect’s sake those days will be shortened." - Matthew 24:22. We're right there imho.
psychgirl
Has No Life - Lives on TB
I wonder if this is the same as, or similar to the nasal spray, I bought at the Indian pharmacy two years ago where we bought our ivm?(fair use applies)Game-Changer Nasal Spray: A Universal Shield Against All COVID-19 Variants
Researchers have developed a molecule that is, when administered nasally, extremely effective in preventing the disease caused by all known variants of SARS-CoV-2, the virus that causes COVID-19. The molecule can be a key tool in preparing for future pandemics, as it is aimed at preventing both thescitechdaily.com
Game-Changer Nasal Spray: A Universal Shield Against All COVID-19 Variants
By University of Helsinki
March 28, 2023
Researchers have developed a molecule that is, when administered nasally, extremely effective in preventing the disease caused by all known variants of SARS-CoV-2, the virus that causes COVID-19. The molecule can be a key tool in preparing for future pandemics, as it is aimed at preventing both the transmission and spread of the virus.
In laboratory animal studies, a molecule known as TriSb92, developed by researchers at the University of Helsinki, has been confirmed as affording effective protection against coronavirus infection. The molecule identifies a region in the spike protein of the coronavirus common to all current variants of the virus and inhibits its functioning.
“When administered nasally, the TriSb92 molecule is extremely effective in preventing infection, and experiments carried out in cell cultures indicate that it also encompasses the very latest variants, including XBB, BF7, and BQ.1.1,” explains Postdoctoral Researcher Anna R. Mäkelä from Professor Kalle Saksela’s research group.
Animal models have also demonstrated that, unlike face masks, the molecule can, when sprayed into the nose, prevent infection even after a few hours of exposure.
According to the researchers, the molecule remains fully functional at room temperature for at least 18 months, making it well-suited for use as a nasal spray.
The results were published on March 24 in the Nature Communications journal.
Anticipation of future viral variants
While the worst stage of the coronavirus pandemic is, at least for the time being, behind us, nasally administered protection can be a crucial help in preventing the spread of the virus in the future.
“The latest variants effectively avoid the immune protection provided by both vaccines and the COVID-19 disease, and current vaccines are not effective in preventing transmission,” Mäkelä says.
Moreover, the nasal spray can protect those people from serious disease who do not gain sufficient immunity from vaccines, such as immunocompromised individuals and elderly.
According to the researchers, the molecule could also work against future animal-borne close relatives of SARS-CoV-2, which are expected to be the cause of entirely new coronavirus pandemics.
“Since the region in the coronavirus’s spike protein affected by the TriSb92 molecule has remained almost unchanged in all viral variants so far emerged, it can be assumed to be effective also against future SARS-CoV-2 variants,” Mäkelä confirms.
“The easily and inexpensively produced TriSb92 could be a very important first line of defense in curbing such a new pandemic, pending the development, production, and distribution of vaccines,” she adds.
A copyable approach
According to the researchers, the sherpabody-technology used is also applicable to the prevention of many other viral diseases, particularly influenza, and other respiratory viruses.
“The whole approach stems from a technical solution based on a binder protein platform developed in Finland, which was not originally intended for the development of an antiviral drug. It provides an opportunity for many other new initiatives based on the accurate identification of diseased cells or pathogens in patients,” Mäkelä says.
In the next stage, the molecule must be tested in clinical trials, after which it could be made commercially available.
“Successful commercialization of the nasal spray could lead to the creation of a thriving Finnish business,” Mäkelä points out.
Reference: “Intranasal trimeric sherpabody inhibits SARS-CoV-2 including recent immunoevasive Omicron subvariants” by Anna R. Mäkelä, Hasan Uğurlu, Liina Hannula, Ravi Kant, Petja Salminen, Riku Fagerlund, Sanna Mäki, Anu Haveri, Tomas Strandin, Lauri Kareinen, Jussi Hepojoki, Suvi Kuivanen, Lev Levanov, Arja Pasternack, Rauno A. Naves, Olli Ritvos, Pamela Österlund, Tarja Sironen, Olli Vapalahti, Anja Kipar, Juha T. Huiskonen, Ilona Rissanen and Kalle Saksela, 24 March 2023, Nature Communications.
DOI: 10.1038/s41467-023-37290-6
I’ll look at the box for the name of it.
I can’t remember off the top, but I’ve not even used it yet because it was a pricey, small bottle.
I was told by the pharmacist there, that they all used it before going to any gatherings of people.
Heliobas Disciple
TB Fanatic
I kind of doubt it because this something new they just discovered. That being said I am really curious as to what you did buy - can you let us know after you find the box? I'm wondering if it is xylitol based, that is something we've discussed extensively on this thread in the past. It's supposed to be an excellent prophylactic.
HD
psychgirl
Has No Life - Lives on TB
I sure will! I’ll do it after work today
Chicory
#KeeptheRepublic
Italian Doctor Suspended for Suggesting Autopsies of Sudden Deaths
We do not need no stinking autopsies, say Italian medical officials.
dailyclout.io
Italian Doctor Suspended for Suggesting Autopsies of Sudden Deaths
March 29, 2023 • by Igor ChudovWe do not need no stinking autopsies, say Italian medical officials.
Originally Published on Igor’s Newsletter.Italian doctor Valerio Petterle was publicly asked about sudden deaths. He suggested that sudden deaths of adults are on the rise and recommended doing more autopsies to discover why people are dying unexpectedly.
For this suggestion, Dr. Petterle was suspended for two months (English translation, archive link in Italian).
«Morti improvvisa in aumento, servono più autopsie»: medico sospeso per due mesi
Italian medical authorities and boards are not interested in doing autopsies to understand excess mortality in Italy. Instead, they suspended the doctor, who suggested looking into the sudden deaths of Italians.
The Italian health authorities have a problem they should investigate: in 2022, Italy had excess mortality of 11-25%.
Short-term Mortality Fluctuations - Human Mortality Database
mpidr.shinyapps.io
What made Italians die at excess rates in 2022? We have no idea! We only know that Italian health officials do NOT want us to know the answer. Instead, they suspend doctors who recommend doing more autopsies.
I am sorry for the brave Italian doctor Valerio Petterle. I hope that he does not give up.
As the suddenly dying people are buried or cremated, we may never have the proof of why they died – which is exactly what Italian medical boards want.
A perfect crime needs a perfect coverup!
Dr. Petterle is not alone. When a brave British parliamentarian Andrew Bridgen suggested that excess deaths in the UK were a national emergency, he was falsely accused of antisemitism. Matt Hancock, a mastermind of British lockdowns, and Rishi Sunak, a WEF member who profited mightily from COVID vaccine companies, were at the forefront of these false accusations.
So, ignoring excess deaths and vilifying those who call for investigations into their causes is not a purely Italian problem.
Now, when autopsies are done properly, as University of Heidelberg pathologists did in Germany, they discover damage caused by the COVID vaccines:
Link to the above piece.
Do you think they will be able to cover up the causes of sudden deaths in Italy and elsewhere?
Heliobas Disciple
TB Fanatic
WHO revises COVID-19 vaccine recommendations for Omicron-era
The U.N. agency said the aim was to focus efforts on vaccinating those facing the greatest threat of severe disease and death from COVID-19, considering the high-level population immunity worldwide due to widespread infection and vaccination. The health agency defined high-risk populations as...
WHO revises COVID-19 vaccine recommendations for Omicron-era
by Bhanvi Satija in Bengaluru and Jennifer Rigby in London
Tue, March 28, 2023, 9:52 AM EDT·2 min read
(Reuters) - The World Health Organization has tailored its COVID-19 vaccination recommendations for a new phase of the pandemic, suggesting that healthy children and adolescents may not necessarily need a shot but older, high-risk groups should get a booster between 6 to 12 months after their last vaccine.
The U.N. agency said the aim was to focus efforts on vaccinating those facing the greatest threat of severe disease and death from COVID-19, considering the high-level population immunity worldwide due to widespread infection and vaccination.
The health agency defined high-risk populations as older adults, as well as younger people with other significant risk factors. For this group, the agency recommends an additional shot of the vaccine either 6 or 12 months after the latest dose, based on factors such as age and immunocompromising conditions.
Meanwhile, it said healthy children and adolescents were "low priority" for COVID-19 vaccination, and urged countries to consider factors like disease burden before recommending vaccination of this group. It said the COVID-19 vaccines and boosters were safe for all ages, but the recommendations took into account other factors like cost-effectiveness.
The WHO said in September last year that the end of the pandemic was "in sight". In a briefing on Tuesday, the agency said its latest advice reflected the current disease picture and global immunity levels, but should not be seen as long-term guidance over whether annual boosters would be needed.
The recommendations come as countries take differing approaches. Some high-income countries like the United Kingdom and Canada are already offering those at high-risk COVID-19 boosters this spring, six months after their last dose.
"The revised roadmap re-emphasises the importance of vaccinating those still at-risk of severe disease," said Hanna Nohynek, chair of the WHO's Strategic Group of Experts on immunisation, which made the recommendations.
The committee also called for urgent efforts to catch up. on routine vaccinations missed during the pandemic and warned of a rise in vaccine-preventable diseases like measles.
For COVID, it said that vaccines beyond the initial two shots and a booster were no longer routinely recommended for those at "medium risk" as benefits were marginal.
Heliobas Disciple
TB Fanatic
What WHO’s New Covid-19 Vaccine Guidance Means for Pfizer and Moderna Stock
The two companies have said they expect roughly 100 million Covid-19 vaccines doses to be administered in the U.S. this year.
What WHO’s New Covid-19 Vaccine Guidance Means for Pfizer and Moderna Stock
Josh Nathan-Kazis - BARRONS
Wed, March 29, 2023, 12:08 PM EDT
The World Health Organization’s newest guidance on Covid-19 vaccinations only recommends regular boosters for older adults, and suggests that demand for shots could be weaker in coming years than vaccine makers have anticipated.
The WHO’s vaccines advisors said Tuesday they don’t recommend annual Covid-19 vaccine boosters for healthy adults under ages 50 to 60 after they have received their first vaccine and booster, and they no longer recommend vaccinating healthy children or teens against the virus.
The guidance takes into account the diminished threat from Covid-19, and the need to commit resources to vaccinating for other diseases, the WHO’s Strategic Advisory Group of Experts on Immunization, or SAGE, said Tuesday.
“We know that we are living in an Omicron era, where the disease severity is reduced, thanks to high population-level immunity, which has been obtained either through infection or vaccine or both,” said SAGE’s chair, Dr. Hanna Nohynek.
Health authorities in the U.S. and many other countries continue to recommend a dose of a bivalent Covid-19 vaccine booster for anyone over the age of 6 months. The latest WHO guidelines represent a significant step away from that stance, and come as Covid-19 vaccine makers face pushback in the U.S. over pricing and as health officials consider a postpandemic future.
It isn’t clear how the U.S. will react to the revised WHO guidance, which isn’t binding. For now, the country is moving toward a fall 2023 Covid-19 booster campaign. The Food and Drug Administration has said it expects to hold a meeting of its vaccine advisors in June to determine which virus strain the fall boosters should target.
Nonetheless, the revised guidance points to dropping global demand for Covid-19 vaccines in coming years. Just how much demand could fall remains a vital question for leading Western Covid-19 vaccine makers Pfizer (ticker: PFE) and Moderna (MRNA).
Pfizer and Moderna both have said they expect roughly 100 million Covid-19 vaccines doses to be administered in the U.S. this year, down from 144 million in 2022.
Wall Street analysts expect Moderna’s Covid-19 vaccine sales to drop to $6.5 billion in 2024 from $18.4 billion in 2022, according to FactSet, though estimates range widely. Analysts expect Pfizer’s Covid-19 vaccine sales to drop to $12.1 billion in 2024, from $37.8 billion in 2022, also according to FactSet.
The FDA and Moderna didn’t immediately respond to a request for comment Wednesday. Pfizer, in a statement, said that Covid-19 remains a public-health threat.
“As we continue the fight against Covid-19, vaccination remains one of the best lines of defense against symptomatic disease, severe disease, and hospitalization,” a Pfizer spokesperson said. “It is, therefore, crucial for individuals to stay up-to-date on vaccination, as recommended by local health authorities.”
WHO officials also voiced skepticism over the advantages offered by the bivalent vaccines, which Moderna and Pfizer have rolled out in response to FDA requests. At a Tuesday news conference, the organization said there was “minimal evidence” showing that bivalent vaccines are more effective than monovalent vaccines, which specifically target Covid’s original strain.
“There is some additional benefit for symptomatic disease by giving the bivalent compared with the monovalent,” Dr. Kate O’Brien, director of the WHO’s department of immunization, vaccines, and biologicals, said Tuesday. “But for severe disease, we have no evidence that the bivalent product is better than the monovalent product.”
The new SAGE guidance recommends Covid-19 boosters for older adults, pregnant people, front-line health workers, younger adults with serious comorbidities like diabetes and heart disease, and people with immunocompromising conditions. People in those categories should receive boosters every six or 12 months, depending on various factors, the committee said.
SAGE said the vaccines are safe and effective for healthy children and teens up to the age of 17, but that countries should focus their efforts elsewhere, given the low burden of disease in that age group. SAGE advises vaccinating pregnant people to protect infants under the age of six months.
Heliobas Disciple
TB Fanatic
AstraZeneca’s COVID Vaccine May Have Posed a Higher Heart Risk for Young Women, Study Shows
Young women who received at least one dose of the COVID vaccine made by AstraZeneca may have been more likely to die of a heart problem in the 12 weeks after their vaccination, according to an analysis of immunization and death records in Britain released Monday. Those findings carry a big...
AstraZeneca’s COVID Vaccine May Have Posed a Higher Heart Risk for Young Women, Study Shows
Apoorva Mandavilli - NY Times
Wed, March 29, 2023, 2:29 PM EDT
Young women who received at least one dose of the COVID vaccine made by AstraZeneca may have been more likely to die of a heart problem in the 12 weeks after their vaccination, according to an analysis of immunization and death records in Britain released Monday.
Those findings carry a big caveat: Britain withdrew AstraZeneca’s vaccine use for people younger than 30 in April 2021, citing the risk of rare but dangerous blood clots. By that time, the young women who were immunized would have been mainly health care workers or those who were medically vulnerable, because people at high risk of COVID from their age, health or employment were vaccinated first. So the results of the study may not apply to the general population.
“It could be that the people who are clinically extremely vulnerable are more susceptible to side effects from vaccination,” said Vahé Nafilyan, a senior statistician for Britain’s Office for National Statistics and one of the lead researchers on the study. The results were published Monday in the journal Nature Communications.
The AstraZeneca vaccine was never authorized for use in the United States. But more than 3 billion doses of the vaccine had been delivered worldwide as of November 2022. It is cleared for use in more than 170 countries, although in recent months, some have relied only on bivalent mRNA vaccines for the latest round of booster shots because of omicron’s dominance.
The analysis found six cardiac-related deaths per 100,000 young women who received at least one dose of the vaccine in Britain. In these women, the cardiac-related death was 3.5 times more likely in the 12 weeks following vaccination than after the 12-week period. Clots that block blood flow can cause a heart attack or stroke.
The researchers did not find a significantly elevated risk of death in any other subgroup or with the Pfizer-BioNTech mRNA vaccine, which was also widely used in Britain. And the study did not prove that the vaccines caused the deaths.
The benefits of COVID vaccines still vastly outweigh the risks, and the incidence of harmful events after vaccination remains very low, the researchers and other experts emphasized.
In the analysis, COVID was associated with one additional death for every 12,000 unvaccinated young people and one additional death for every 56,000 vaccinated young people.
“When you look at vaccination side effects, I think it’s very important to also look at the benefits,” Nafilyan said.
The researchers linked immunization records to deaths from any cause recorded in people age 12 to 29. They looked at data starting Dec. 8, 2020, when the vaccines were rolled out in Britain.
The mortality data came from two independent sources: deaths registered by June 8, 2022, and hospital deaths by March 31, 2022.
The team found a very small increase in cardiac-related deaths in the 12 weeks after vaccination in young men after a second dose of an mRNA vaccine, but said that the finding was not statistically significant. Only young women — just over 177,000 — who received at least one dose of AstraZeneca had a higher risk of cardiac-related death.
The analysis does not conclusively link the vaccines to the deaths, experts cautioned.
“It’s enough to catch my interest and say we should study this more,” said Daniel Salmon, director of the Institute for Vaccine Safety at Johns Hopkins Bloomberg School of Public Health. But “I wouldn’t come close to drawing any causal conclusions.”
“Overall it’s fairly reassuring, but it does bring up some vaccines and some populations that deserve further study,” Salmon said.
Other studies have linked vaccine side effects to specific subgroups. Data from several countries link the mRNA COVID vaccines to an elevated risk of myocarditis and pericarditis — inflammation of the heart or its outer lining — particularly in males between the ages of 12 and 29.
Within weeks of its introduction, the AstraZeneca vaccine was linked to a rare blood-clotting disorder, particularly in young women in Britain and other countries in Europe. Although AstraZeneca’s vaccine did not clear U.S. regulatory approval, the Food and Drug Administration in December 2020 authorized a similar vaccine made by Johnson & Johnson.
In April 2021, the FDA called for a pause in use of the Johnson & Johnson vaccine, following reports of a blood-clotting disorder in six American women. The agency withdrew the recommended pause 10 days later and amended the vaccine’s label to warn about the risk.
A year later, the FDA again restricted the vaccine’s use, saying it should be offered only to people who could not or would not opt for one of the mRNA vaccines. By then, the agency had received reports of 60 cases of the clotting disorder and nine deaths, out of 18 million doses administered.
“Fortunately, as more and more of these types of data are collected and become public, we can continue to rest assured that the rate of serious side effects — referred to as adverse events — is remarkably low for both types of vaccines,” Dr. Susan Cheng, a cardiologist and public health researcher at the Smidt Heart Institute at Cedars Sinai in Los Angeles, said of mRNA and non-mRNA vaccines.
“That said, while the rates of these adverse events remains extremely low,” she said, “they are important, and they need to be counted and analyzed so that we can understand them better.”
Heliobas Disciple
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Senate votes to end COVID-19 national emergency
The Senate on Wednesday passed a GOP-led resolution that would end the COVID-19 national emergency that has been in place since 2020. The measure passed the upper chamber 68-23. A similar resolutio…
thehill.com
Senate votes to end COVID-19 national emergency
by Nathaniel Weixel
03/29/23 7:33 PM ET
The Senate on Wednesday passed a GOP-led resolution that would end the COVID-19 national emergency that has been in place since 2020.
The measure passed the upper chamber 68-23.
A similar resolution sponsored by Sen. Roger Marshall (R-Kan.) passed the Senate last year, but it did not advance in the Democrat-controlled House. This year it passed the House 229-197, with 11 Democrats joining all Republicans.
President Biden last year threatened to veto the measure. This year, he did not threaten a veto but issued a statement of administration principles before the House vote objecting to the resolution.
On Wednesday, however, he said he would sign the measure.
“The President strongly opposes HJ Res 7, and the administration is planning to wind down the COVID national emergency and public health emergency on May 11. If this bill comes to his desk, however, he will sign it, and the administration will continue working with agencies to wind down the national emergency with as much notice as possible to Americans who could potentially be impacted,” a White House official said.
The national emergency is different from the public health emergency, though the White House will end both on May 11. Under federal law, Congress has the power to ask for periodic votes to terminate a national emergency.
President Biden used the powers under the national emergency declaration as the underpinning for his student loan forgiveness plan, which is currently tied up in court.
The initial declaration allowed the Federal Emergency Management Agency (FEMA) to mobilize personnel to support state and local agencies as they worked to combat the virus. The move also allowed FEMA to access billions of dollars.
Ending the national emergency early could also terminate some of the flexibility that COBRA has been able to exercise.