psychgirl
Has No Life - Lives on TB
Thank you for the review.
CORONA Main Coronavirus thread
- Thread starter Heliobas Disciple
- Start date
-
- Tags
- coronavirus
Heliobas Disciple
TB Fanatic
Study: Experimental COVID shot made via egg-based technology elicits higher antibody proportion than mRNA vax
An experimental COVID-19 vaccine produced with technology based on a decades-old method, elicited virus-neutralizing antibodies in higher proportion than the amount induced by mRNA immunizations, a Phase 1 clinical trial has found.
Study: Experimental COVID shot made via egg-based technology elicits higher antibody proportion than mRNA vax
by Delthia Ricks, Medical Xpress
March 16, 2023
Neutralizing activity of vaccinee and convalescent serum samples against wild-type SARS-CoV-2 and Delta and Beta variants.Neutralization was measured against (A) wild-type SARS-CoV-2 strain USA-WA01/2020, (B) a Delta (B.1.617.2) isolate, and (C) a Beta (B.1.351) isolate in a microneutralization assay with authentic SARS-CoV-2. For vaccine groups, n = 35, nBNT162b2 = 20, and nHCS = 18. The exception is n3 μg = 34 in (B) and n3 μg = 31 in (C); n1 μg = 34 and n3 μg + ODN1018 = 34 in (C); and the nplacebo = 34 in (A) and nplacebo = 32 in (B) and (C), due to a lack of sample volume. Bars show GMT, and error bars indicate SD of the GMT. The horizontal dotted lines indicate the limit of detection; values below the limit of detection were assigned a value of half of the limit of detection. For statistical analysis, log-transformed neutralization titers were compared using a Kruskal-Wallis test corrected for multiple comparisons using Dunn’s multiple comparisons test. P values for significant differences are indicated in the panels. Experiments were performed once. The vertical dashed lines indicate that the samples on the left are from the clinical trial in Thailand, whereas the samples on the right are from the PARIS study in New York City. Credit: Science Translational Medicine (2023). DOI: 10.1126/scitranslmed.abo2847
An experimental COVID-19 vaccine produced with technology based on a decades-old method, elicited virus-neutralizing antibodies in higher proportion than the amount induced by mRNA immunizations, a Phase 1 clinical trial has found.
The investigational vaccine was developed in New York City and tested in Thailand where the shots were produced using a form of egg-based technology. The fact that researchers are still racing to develop new COVID-19 vaccines highlights an ongoing need, especially in low- and middle-income countries—and for good reason.
A surprising slew of omicron subvariants has emerged since 2021. Last year, omicron spawned a dizzying number of subvariants: BA.5, BQ.1, and BQ.1.1. By January of this year, a new omicron subvariant called XBB.1.5 was sweeping across the United States and beyond.
"A large number of vaccines for SARS-CoV-2 have been developed and licensed," asserted Juan Manuel Carreño, writing with a team of researchers in Science Translational Medicine. As a research scientist in the microbiology department at Mount Sinai's Icahn School of Medicine in New York City where the vaccine was developed, Carreño underscored the need for effective and affordable COVID shots in overlooked regions of the world.
"There is a need for SARS-CoV-2 vaccines that can be produced at low cost locally in low- and middle-income countries," added Carreño, lead author of the new analysis. The study analyzed antibody responses elicited by the investigational vaccine known as NDV-HXP-S, which is produced in hens' eggs.
The research found that the investigational vaccine prompted a higher proportion of neutralizing antibodies against SARS-CoV-2 in volunteers compared with the proportion of neutralizing antibodies produced by a separate group of people who were vaccinated with Pfizer's mRNA vaccine.
A neutralizing antibody is one that defends healthy cells from a virus by neutralizing the pathogen's efforts to get inside. For instance, a neutralizing antibody can stop a virus from making a conformational change—swapping its structure for a new shape. Viral shape-shifting is a way to infect a cell.
Neutralizing antibodies differ from binding antibodies, which latch onto the pathogen and alert warrior cells of the immune system that a viral invasion is underway. While people who were vaccinated with NDV-HXP-S had a higher proportion of neutralizing antibodies, their binding to neutralizing antibody ratios were lower than those who were vaccinated with Pfizer's mRNA vaccine. When all variables were taken into account, the team concluded that the antibody responses between the two vaccines were comparable.
Findings from the research suggest that even in regions with previously limited vaccine-production infrastructure, it's possible to manufacture robust COVID shots at low cost. Western countries averse to technology sharing early in the pandemic, a factor that left scores of people in low- and middle-income countries with few opportunities for vaccination. Now, the tide is turning, albeit three years after the global SARS-CoV-2 pandemic was declared.
"Locally produced vaccines can increase vaccine access and vaccine independence, especially for low- and middle-income countries," Carreño added. "The NDV-HXP-S vaccine is designed to help close this gap because it can be economically produced in influenza vaccine manufacturing plants that are located in [these countries]. Moreover, it can be stored and distributed without the need for freezers."
Although mRNA vaccines have dominated the U.S. response to the pandemic, the technology underlying those shots is expensive. The finicky, temperature-sensitive ingredients required for mRNA vaccines may be difficult to store in far-flung regions of the globe. To address the global need for a low-cost vaccine that can be produced locally, scientists have been developing alternatives, such as NDV-HXP-S.
The vaccine's initials, NDV-HXP-S, stand for Newcastle disease virus, HexaPro, and spike protein. Producing the vaccine involves a vector, which in this case is the Newcastle disease virus, an agent that infects birds. The vaccine is manufactured by way of egg-based technology, which has been used for decades to produce annual flu shots. The Newcastle viral vector is not used in the production of influenza vaccines.
The vector works exquisitely well in the NDV-HXP-S production process, ferrying vaccine components into embryonated chicken eggs. The result, in the case of the vaccine used in Thailand, is an inactivated vaccine, which is a viral particle displaying SARS-C0V-2's spike protein on its surface.
"NDV-HXP-S can be used as a live vaccine or as an inactivated vaccine," Carreño explained, noting in Science Translational Medicine that clinical trials with a live version of the vaccine are ongoing in Mexico and the United States. As in Thailand, clinical trials in Vietnam and Brazil involve an inactivated form of the vaccine.
The NDV-HXP-S immunization was developed at Mount Sinai's Icahn School of Medicine in New York City by world-renowned virologists and vaccinologists, Drs. Peter Palese, Adolfo Garcia-Sastre and Florian Krammer, all leading members of the current clinical research.
The team analyzed antibody responses after Thai volunteers were vaccinated in the phase 1 clinical study. Researchers studied serum samples from 210 Thai volunteers who received either a placebo or the inactivated NDV-HXP-S vaccine.
They compared antibodies from the Thai volunteers to those from 20 people who received the Pfizer mRNA vaccine in New York City. Antibodies elicited by NDV-HXP-S tended to target the receptor binding domain of the virus rather than the spike protein's S2 subunit, the researchers found.
"Neutralizing activity of sera from NDV-HXP-S vaccinees was comparable to that of [Pfizer] vaccinees, whereas spike protein binding activity of the NDV-HXP-S vaccinee samples was lower than that of sera obtained from mRNA vaccines," Carreño and colleagues wrote. "This led us to calculate ratios between binding and neutralizing antibody titers.
"In summary, we show that a vaccine candidate that can be produced locally in [low- and middle-income countries] at low-cost induces neutralizing antibody titers to SARS-CoV-2 comparable to those observed in cohorts having received mRNA-based COVID-19 vaccines," Carreño concluded.
Heliobas Disciple
TB Fanatic
Not a Joke: "New Evidence" that Was Actually Obtained in Early 2020 Suggests "Raccoon Dogs" Responsible for COVID-19 | The Gateway Pundit | by Brian Lupo
As the Chinese Communist Party is demanding Sen.
www.thegatewaypundit.com
Not a Joke: “New Evidence” that Was Actually Obtained in Early 2020 Suggests “Raccoon Dogs” Responsible for COVID-19
by Brian Lupo
Mar. 17, 2023 9:45 pm
As the Chinese Communist Party is demanding Sen. Josh Hawley takes down his COVID Origins Bill as reported by The Gateway Pundit and the Department of Energy and FBI are acknowledging that COVID likely came from a Wuhan Lab, new evidence reported by The Atlantic has just emerged suggesting it came from…checks notes…”raccoon dogs”.
Cute little guys!
According to The Atlantic‘s most recent article conveniently titled “The Strongest Evidence Yet That an Animal Started the Pandemic”:
“…many scientists have stood by the notion that this outbreak—like most others—had purely natural roots. But that hypothesis has been missing a key piece of proof: genetic evidence from the Huanan Seafood Wholesale Market in Wuhan, China, showing that the virus had infected creatures for sale there.”
Now, an international team of virologists, genomicists, and evolutionary biologists may have finally found crucial data to help fill that knowledge gap. A new analysis of genetic sequences collected from the market shows that raccoon dogs being illegally sold at the venue could have been carrying and possibly shedding the virus at the end of 2019. It’s some of the strongest support yet, experts told me, that the pandemic began when SARS-CoV-2 hopped from animals into humans, rather than in an accident among scientists experimenting with viruses.”
How convenient.
This data apparently comes from Chinese scientists who have submitted a paper awaiting publication. It has not been peer reviewed, however, The Atlantic and other mockingbird outlets couldn’t wait to suggest the Department of Energy and the FBI that they are wrong.
The Washington Post couldn’t wait to run the unpublished, not yet peer reviewed “study”. The WaPo article states:
The new evidence comes via swabs taken in animal stalls at the Huanan Seafood Market in Wuhan. Investigators collected them in early 2020 after the market had been closed and all the animals removed. Oneswab contained a mixture of genetic material that included a large amount from a raccoon dog along with tracesfrom the coronavirus, said Stephen Goldstein, a virologist at the University of Utah who was part of the team that analyzed the data.
I guess the source of the global pandemic that killed millions wasn’t important enough an issue to adequately complete the analysis of the swabs they took over 3 years ago in “early 2020”.
A raccoon dog, despite the name, is an actual dog that is close to the fox in terms of genetics that lives in East Asia. This is the first mention of a “raccoon dog”, or any dog for that, being the originator of the COVID-19 virus with this “new evidence” found over three and a half years after the COVID-19 virus was first discovered.
Yeah right.....Bravo Sierra....(fair use applies)Not a Joke: "New Evidence" that Was Actually Obtained in Early 2020 Suggests "Raccoon Dogs" Responsible for COVID-19 | The Gateway Pundit | by Brian Lupo
As the Chinese Communist Party is demanding Sen.
Not a Joke: “New Evidence” that Was Actually Obtained in Early 2020 Suggests “Raccoon Dogs” Responsible for COVID-19
by Brian Lupo
Mar. 17, 2023 9:45 pm
As the Chinese Communist Party is demanding Sen. Josh Hawley takes down his COVID Origins Bill as reported by The Gateway Pundit and the Department of Energy and FBI are acknowledging that COVID likely came from a Wuhan Lab, new evidence reported by The Atlantic has just emerged suggesting it came from…checks notes…”raccoon dogs”.
Cute little guys!
According to The Atlantic‘s most recent article conveniently titled “The Strongest Evidence Yet That an Animal Started the Pandemic”:
“…many scientists have stood by the notion that this outbreak—like most others—had purely natural roots. But that hypothesis has been missing a key piece of proof: genetic evidence from the Huanan Seafood Wholesale Market in Wuhan, China, showing that the virus had infected creatures for sale there.”Now, an international team of virologists, genomicists, and evolutionary biologists may have finally found crucial data to help fill that knowledge gap. A new analysis of genetic sequences collected from the market shows that raccoon dogs being illegally sold at the venue could have been carrying and possibly shedding the virus at the end of 2019. It’s some of the strongest support yet, experts told me, that the pandemic began when SARS-CoV-2 hopped from animals into humans, rather than in an accident among scientists experimenting with viruses.”
How convenient.
This data apparently comes from Chinese scientists who have submitted a paper awaiting publication. It has not been peer reviewed, however, The Atlantic and other mockingbird outlets couldn’t wait to suggest the Department of Energy and the FBI that they are wrong.
The Washington Post couldn’t wait to run the unpublished, not yet peer reviewed “study”. The WaPo article states:
The new evidence comes via swabs taken in animal stalls at the Huanan Seafood Market in Wuhan. Investigators collected them in early 2020 after the market had been closed and all the animals removed. Oneswab contained a mixture of genetic material that included a large amount from a raccoon dog along with tracesfrom the coronavirus, said Stephen Goldstein, a virologist at the University of Utah who was part of the team that analyzed the data.
I guess the source of the global pandemic that killed millions wasn’t important enough an issue to adequately complete the analysis of the swabs they took over 3 years ago in “early 2020”.
A raccoon dog, despite the name, is an actual dog that is close to the fox in terms of genetics that lives in East Asia. This is the first mention of a “raccoon dog”, or any dog for that, being the originator of the COVID-19 virus with this “new evidence” found over three and a half years after the COVID-19 virus was first discovered.
Heliobas Disciple
TB Fanatic
btw, that's now a trending story. It was so ridiculous I didn't want to post it, so posted the Gateway Pundit's story about it instead. But look at all who are now reporting this as the 'truth'... and this is just a sample. Do you think the MSM was told to publish this story to help Fauci and to debunk the recent studies that it was a lab leak (which incidentally the majority of people now believe it was a lab leak according to recent polling, see next article)
apnews.com
www.nytimes.com
www.theatlantic.com
www.theguardian.com
abcnews.go.com
www.nbcnews.com
www.cbsnews.com
www.forbes.com
New COVID origins data point to raccoon dogs in China market
The mystery to the origins of the COVID-19 pandemic now has some new clues. International scientists have found raccoon dog DNA comingled with the virus in previously unavailable genetic data.
apnews.com
New Data Links Pandemic’s Origins to Raccoon Dogs at Wuhan Market
Genetic samples from the market were recently uploaded to an international database and then removed after scientists asked China about them.
The Strongest Evidence Yet That an Animal Started the Pandemic
A new analysis of genetic samples from China appears to link the pandemic’s origin to raccoon dogs.
www.theatlantic.com
New data links Covid-19’s origins to raccoon dogs at Wuhan market
Analysis of gene sequences by international team finds Covid-positive samples rich in raccoon dog DNA
www.theguardian.com
New report suggests COVID pandemic's origins linked to raccoon dogs at Wuhan market
A new report from a team of international researchers suggests the COVID pandemic's origins may be linked to raccoon dogs that were being sold at a wet market in Wuhan.
abcnews.go.com
New Covid origins data suggests pandemic linked to raccoon dogs at Wuhan market
The samples were collected from surfaces at the Huanan seafood market in Wuhan after the first human cases of Covid-19 were found in late 2019.
www.nbcnews.com
New genetic analysis finds clues to animal origin of COVID outbreak
Analysis presented to the WHO offers clues to whether animals, possibly raccoon dogs, were infected at the Huanan animal market in early 2020.
www.cbsnews.com
Genetic Data Links Covid Origins To Raccoon Dogs Sold At Wuhan Wet Market, Reports Say
This finding is the first piece of genetic evidence linking an animal being sold at the wet market to the coronavirus that caused the pandemic.
www.forbes.com
Heliobas Disciple
TB Fanatic
(fair use applies)
How the covid lab leak became the American public’s predominant theory
Analysis by Aaron Blake
March 16, 2023 at 3:33 p.m. EDT
For the second time in a week, a new poll shows Americans leaning strongly toward the belief that the coronavirus leaked from a lab rather than occurring naturally.
The Quinnipiac University poll shows Americans side with the former view by 64 percent to 22 percent. And just last week, an Economist/YouGov poll showed an even stronger split in favor of a lab leak: 66-16.
The polls come shortly after it was reported that the Energy Department concluded the virus was probably a function of a lab leak. Republicans have played up that conclusion as they’ve ramped up congressional probes of the virus’s origins and related issues — even as the Energy Department’s conclusion is described as “low confidence,” and intelligence agencies as a whole remain decidedly split on which theory is more likely.
There is no question that the lab leak theory is ascendant in Americans’ minds, despite the scientific community and some in the media having cast plenty of doubt upon it early on.
But it’s also true that this has clearly been an attractive theory for many Americans for a long time.
The first big-name pollster to test this question was the Pew Research Center. It asked the question in mid-March 2020, shortly after the first covid deaths in the United States were reported. At the time, 43 percent believed the virus came about naturally, but about 3 in 10 thought it was created either intentionally or accidentally in a lab.
And as soon as a few months later, those views were effectively tied in Americans’ minds in another poll in September 2020, after President Donald Trump and others had promoted the theory. A Public Religion Research Institute poll then showed 50 percent thought it was developed intentionally in a lab, while 49 percent thought it developed naturally.
Another PRRI poll six months later showed more skepticism of the lab leak theory, with only about 4 in 10 backing it. But by June 2021, a Politico-Harvard poll showed Americans embracing it by a nearly 2-to-1 margin, 52-28.
As The Washington Post’s Dan Diamond noted recently, by this point many Trump critics had begun treating this as more of an open question. The Biden administration launched a 90-day investigation of the virus’s origins in May 2021 (it was inconclusive). And shortly before the June 2021 poll went into the field, comedian Jon Stewart went viral for a bit playing up the possibility.
“Science has, in many ways, helped ease the suffering of this pandemic,” Stewart said, before adding for effect, “which was more than likely caused by science.”
The reasons this has long been an attractive theory are self-evident, and Stewart’s bit hit on a number of them. Among them are that it’s a relatively simple-sounding theory to address a complex issue. (It’s much easier to grasp the idea that something so deadly was created intentionally — or leaked intentionally — rather than that it somehow just happened.) It also carries the benefit of designating a bona fide culprit for something people were, and are, understandably angry about. China’s lack of transparency has undoubtedly increased suspicion.
And indeed, if you look a little more closely, you can see views in favor of a lab leak taking off even earlier.
The Economist and YouGov have actually asked this question repeatedly over time, but in a different way than others. Rather than pit a lab leak against natural transmission, it asked, “Regardless of whether or not the virus responsible for COVID-19 was created or naturally mutated, do you believe it is true or false that a laboratory in China was the origin of the virus?”
This question allowed people to believe a lab was responsible without necessarily believing the virus was deliberately created (which to many people might sound like the more-conspiratorial “bioweapon” theory). And as early as May 2020, YouGov showed Americans leaned in the direction of a lab playing some role. Half favored it, while just 3 in 10 thought it was false that a lab was involved.
Given that Americans arguably already favored a lab leak theory at that very early juncture, it shouldn’t be too surprising that it’s become such a strong favorite — even as it’s not yet such a strong favorite within the government and the scientific community.
How the covid lab leak became the American public’s predominant theory
Analysis by Aaron Blake
March 16, 2023 at 3:33 p.m. EDT
For the second time in a week, a new poll shows Americans leaning strongly toward the belief that the coronavirus leaked from a lab rather than occurring naturally.
The Quinnipiac University poll shows Americans side with the former view by 64 percent to 22 percent. And just last week, an Economist/YouGov poll showed an even stronger split in favor of a lab leak: 66-16.
The polls come shortly after it was reported that the Energy Department concluded the virus was probably a function of a lab leak. Republicans have played up that conclusion as they’ve ramped up congressional probes of the virus’s origins and related issues — even as the Energy Department’s conclusion is described as “low confidence,” and intelligence agencies as a whole remain decidedly split on which theory is more likely.
There is no question that the lab leak theory is ascendant in Americans’ minds, despite the scientific community and some in the media having cast plenty of doubt upon it early on.
But it’s also true that this has clearly been an attractive theory for many Americans for a long time.
The first big-name pollster to test this question was the Pew Research Center. It asked the question in mid-March 2020, shortly after the first covid deaths in the United States were reported. At the time, 43 percent believed the virus came about naturally, but about 3 in 10 thought it was created either intentionally or accidentally in a lab.
And as soon as a few months later, those views were effectively tied in Americans’ minds in another poll in September 2020, after President Donald Trump and others had promoted the theory. A Public Religion Research Institute poll then showed 50 percent thought it was developed intentionally in a lab, while 49 percent thought it developed naturally.
Another PRRI poll six months later showed more skepticism of the lab leak theory, with only about 4 in 10 backing it. But by June 2021, a Politico-Harvard poll showed Americans embracing it by a nearly 2-to-1 margin, 52-28.
As The Washington Post’s Dan Diamond noted recently, by this point many Trump critics had begun treating this as more of an open question. The Biden administration launched a 90-day investigation of the virus’s origins in May 2021 (it was inconclusive). And shortly before the June 2021 poll went into the field, comedian Jon Stewart went viral for a bit playing up the possibility.
“Science has, in many ways, helped ease the suffering of this pandemic,” Stewart said, before adding for effect, “which was more than likely caused by science.”
The reasons this has long been an attractive theory are self-evident, and Stewart’s bit hit on a number of them. Among them are that it’s a relatively simple-sounding theory to address a complex issue. (It’s much easier to grasp the idea that something so deadly was created intentionally — or leaked intentionally — rather than that it somehow just happened.) It also carries the benefit of designating a bona fide culprit for something people were, and are, understandably angry about. China’s lack of transparency has undoubtedly increased suspicion.
And indeed, if you look a little more closely, you can see views in favor of a lab leak taking off even earlier.
The Economist and YouGov have actually asked this question repeatedly over time, but in a different way than others. Rather than pit a lab leak against natural transmission, it asked, “Regardless of whether or not the virus responsible for COVID-19 was created or naturally mutated, do you believe it is true or false that a laboratory in China was the origin of the virus?”
This question allowed people to believe a lab was responsible without necessarily believing the virus was deliberately created (which to many people might sound like the more-conspiratorial “bioweapon” theory). And as early as May 2020, YouGov showed Americans leaned in the direction of a lab playing some role. Half favored it, while just 3 in 10 thought it was false that a lab was involved.
Given that Americans arguably already favored a lab leak theory at that very early juncture, it shouldn’t be too surprising that it’s become such a strong favorite — even as it’s not yet such a strong favorite within the government and the scientific community.
Heliobas Disciple
TB Fanatic
Pfizer, CDC Withheld Evidence of Myocarditis After COVID Shots, New Documents Reveal
Pfizer and the Centers for Disease Control and Prevention (CDC) withheld evidence that COVID-19 vaccinations were causing myocarditis, according documents obtained by Children’s Health Defense via a Freedom of Information Act request to the CDC, and documents leaked this week to Project Veritas.
childrenshealthdefense.org
Pfizer, CDC Withheld Evidence of Myocarditis After COVID Shots, New Documents Reveal
Pfizer and the Centers for Disease Control and Prevention (CDC) withheld evidence that COVID-19 vaccinations were causing myocarditis, according documents obtained by Children’s Health Defense via a Freedom of Information Act request to the CDC, and documents leaked this week to Project Veritas.
By Michael Nevradakis, Ph.D.
03/17/23
Pfizer and the Centers for Disease Control and Prevention (CDC) withheld evidence that COVID-19 vaccinations led to an increased risk of myocarditis, especially in young males, according to two sets of documents made public this week.
Confidential Pfizer documents leaked Thursday by Project Veritas show the company had “evidence that suggests patients who receive a COVID-19 vaccine are at an increased risk of myocarditis.”
And heavily redacted CDC documents obtained by Children’s Health Defense (CHD) via a Freedom of Information Act (FOIA) request indicate the agency provided an undercounted figure of post-COVID-19-vaccination myocarditis cases to Israel’s Ministry of Health in early 2021.
The latest revelations come as Germany, Japan and other governments are raising questions about the significant numbers of severe adverse events recorded in individuals following administration of the COVID-19 vaccines.
According to researchers at the National Organization for Rare Disorders, myocarditis can result from infections, or it may result directly from a toxic effect such as a toxin or a virus.
“More commonly the myocarditis is a result of the body’s immune reaction to the initial heart damage,” researchers said.
Severe myocarditis can permanently damage the heart muscle, possibly causing heart failure.
Internal documents contradict Pfizer claim of ‘low incidence of myocarditis’
An internal Pfizer document leaked to Project Veritas on Thursday, updated Feb. 11, 2022, and authored by eight scientists in Pfizer’s Drug Safety Research & Development division, indicates that the drugmaker was aware of a connection between mRNA COVID-19 vaccines and higher incidence rates of myocarditis within two weeks of vaccination — particularly following the second dose of the primary series.
“There is evidence that suggests patients who receive a COVID-19 vaccine are at an increased risk of myocarditis,” the document read.
“Onset was typically within several days after mRNA COVID-19 vaccination (from Pfizer or Moderna), and cases have occurred more often after the second dose than the first dose.”
Pfizer cited CDC data to make this determination:
“Since April 2021, increased cases of myocarditis and pericarditis have been reported in the United States after mRNA COVID-19 vaccination (Pfizer-BioNTech and Moderna), particularly in adolescents and young adults (CDC 2021).”
“The pattern of cases conform, as per the label, to a pattern of myocarditis cases occurring in majority of young males below 29 years of age within the first two weeks post-vaccination.”
“The reasons for male predominance in myocarditis and pericarditis incidence post COVID-19 vaccination remain unknown.”
Although Pfizer couldn’t identify a “clear mechanism” behind the increased risk in males, it did identify several possibilities.
These included direct cardiotoxicity, acute/active viral infection, genetic predisposition and pre-existing conditions, a prior history of myocarditis, immune-mediated mechanisms and vaccine-associated autoimmunity, molecular mimicry to the spike protein and sex-related effects.
These cases occurred, according to the document, despite a claimed low incidence of myocarditis during the clinical trials for the mRNA COVID-19 vaccines.
“Within the participants 16 years of age and older from the Pfizer clinical trial dataset, two cases of pericarditis were reported through the data cut-off date of 18 June 2021,” the document read. “These cases originated from the Phase 3 clinical study C4591001 and both were deemed not related to study treatment by the Investigator.”
“There were no cases of myocarditis reported as serious adverse events through the data cut-off date of 18 June 2021,” the document added.
Based on these incidences of myocarditis, the document states the product labels for the Pfizer COVID-19 vaccine were updated to state:
“Post marketing data demonstrate increased risks of myocarditis and pericarditis, particularly within 7 days following the second dose of the 2-dose primary series.
“The observed risk is higher among males under 40 years of age than among females and older males. The observed risk is highest in males 12 through 17 years of age.”
This change had already been made as of August 2021, according to a document released as part of the so-called “Pfizer documents” — documents pertaining to the U.S. Food and Drug Administration’s (FDA) issuance of Emergency Use Authorization (EUA) to the Pfizer-BioNTech COVID-19 vaccine.
The “Pfizer documents” were released last year by court order following a FOIA request filed by Public Health and Medical Professionals for Transparency.
Another internal Pfizer document from these same “Pfizer documents” states that on July 13, 2021, it was suggested that myocarditis and pericarditis be added “to the PVP” (pharmacovigilance plan).
This addition appears to have taken place.
The Pfizer pharmacovigilance plan of July 28, 2021 — also contained within the “Pfizer documents” release — lists myocarditis and pericarditis as “important identified risk [S ]” identified in Pfizer’s safety database on June 18, 2021.
A pharmacovigilance plan “proposes activities to better characterize and assess the risks during the lifecycle of a medicine. (e.g., to investigate frequency, severity, seriousness and outcome of a risk under normal conditions of use, and/or which populations are particularly at risk).”
Pfizer’s July 28, 2021 pharmacovigilance plan stated that two serious adverse events of pericarditis were reported during the C4591001 clinical trial, although “both [were] deemed not related to study treatment by the Investigator.”
The document also refers to data from Pfizer’s safety database, stating that among people 16 and older, “490 cases reported events related to myocarditis and 371 cases reported events related to pericarditis (in 38 of these 823 cases, the subjects developed both myocarditis and pericarditis related events).”
Of these 490 cases, 26 were later definitively rejected as not being myocarditis, leaving 464 cases ranging from “definitive case” to “reported event.” From there, 459 were listed as “serious,” 337 required hospitalization, and 14 resulted in death.
Nearly 71% of these cases were recorded in males.
Of 371 reported pericarditis cases in individuals 16 and over, all but one was listed as “serious,” 206 required hospitalization, and 3 resulted in death.
Pfizer, in the same pharmacovigilance plan, claimed that no myocarditis or pericarditis cases were recorded in C4591001 trial participants ages 12 to 15.
However, its safety database recorded 11 possible cases of myocarditis — all but one among males, 10 of which were “serious” and nine of which required hospitalization.
Four cases of pericarditis among males between the ages of 12 and 15 also were recorded in the safety database, three of which were considered serious and one of which required hospitalization.
However, in the July 28, 2021 pharmacovigilance plan, Pfizer told the FDA:
“Considering the low rates of myocarditis and pericarditis reported following vaccination, balanced with the risk of death and illness (including myocarditis) caused by SARS-CoV-2, the public health impact of post-vaccination myocarditis and pericarditis is minimal.”
Nevertheless, in another leaked document publicized by Project Veritas, dated May 2022, further confirms Pfizer was aware of the increased incidence of myocarditis.
According to the leaked document:
“Adverse events (AEs) following COVID-19 vaccination are of high clinical importance: even adverse events with small incidence may be seen in appreciable numbers given the massive scope of the vaccination effort.
“There is evidence that suggests patients who received a COVID-19 vaccine are at an increased risk of myocarditis.”
CDC undercounted myocarditis cases in 2021
Documents provided by the CDC in response to an Oct. 12, 2022 FOIA request submitted by CHD reveal the agency provided an undercounted number of recorded myocarditis cases following COVID-19 vaccination to the Israeli Ministry of Health.
The FOIA request asked the CDC to “provide all emails sent by any of the relevant individuals or received by any of the relevant individuals (whether directly or via cc or bcc) containing the search word ‘myocarditis’” between Oct. 1, 2020 and April 30, 2021.
“There has been considerable public discussion of and controversy about how to weigh
the risk of myocarditis that is associated with COVID-19 vaccines,” the request stated. “The public has a significant interest in having a full understanding of how U.S. public health agencies have addressed this issue.”
Following a response by the CDC, CHD on Nov. 17, 2022, narrowed down its request to include only documentation containing the term “myocarditis” within 25 words of “(covid or report* or child* or adolescent* or young*or teen* or male or fatal* or death* or die* or serious or severe or hospital*).”
The heavily redacted 985-page tranche of documents provided to CHD included a Feb. 28, 2021 request, on page 692, from Israel’s Ministry of Health. The request, logged on that date by CDC’s internal task tracking system, stated:
“We are seeing a large number of myocarditis and pericarditis cases in young individuals soon after Pfizer COVID-19 vaccine. We would like to discuss the issue with a relevant expert at CDC.”
A CDC email, dated March 10, 2021, and found on pages 710-714 of the document, read:
“They are investigating a safety signal of myocarditis/myopericarditis in a younger population (16-30 years old) following administration of Pfizer-BioNTech COVID-19 vaccine.
“The Ministry of Health stated they received reports of around 40 cases of this adverse event.”
In the March 10, 2021 response, page 861, sent by the CDC to the Israeli Ministry of Health stated:
“A search of the U.S. Vaccine Adverse Event Reporting System (VAERS) conducted on February 23, 2021 revealed 27 cases (6 cases of myocarditis, 7 cases of myopericarditis, 14 cases pericarditis).
“Twelve cases occurred after dose 1, 7 cases after dose 2, and the dose was not reported for 8 cases. Four patients had comorbid conditions that could suggest alternate etiologies for the adverse event.
“During this analysis period the reporting rate of myopericarditis following administration of the mRNA COVID-19 vaccines was low and estimated to be 0.7 per million doses of vaccine administered.
“However, the limitations of passive surveillance such as under-reporting, lack of a control group, missing and incomplete data make it challenging to assess causation.
“Thus, FDA has not made a final determination regarding the causality between myopericarditis and the mRNA COVID-19 vaccines.”
However, up to Feb. 23, 2021, VAERS had actually received 36 reports of myocarditis — although at that time, the database was significantly backlogged.
It is unclear why data from a Feb. 23, 2021 search was provided by the CDC, when the request from Israel’s Ministry of Health was submitted on Feb. 28, 2021. There is no indication that there was contact from the Israeli health ministry with the CDC regarding this issue prior to Feb. 28, 2021.
While reports submitted to VAERS require further investigation before a causal relationship can be confirmed, the system has been shown to report only 1% of actual vaccine adverse events.
Studies have found further deficiencies in the VAERS system, including deleted or missing reports, the delayed entry of reports and the “recoding of Medical
Dictionary for Regulatory Activities (MedDRA) terms from severe to mild.”
Out of the deleted or missing reports, 13% pertained to deaths and 63% represented severe adverse events.
VAERS data is publicly accessible on the internet and presumably would already have been available to the Israeli Health Ministry as a result, therefore it is unclear why the CDC appears to have relied on this data in its response to Israel.
Moreover, by March 10, 2021, the presumed date of the CDC response to the Israeli Health Ministry, 14 more cases of myocarditis were reported to VAERS, for a total of 49 such cases identified in the database.
Of the 36 myocarditis cases reported to VAERS by Feb. 23, 2021, 25 were in males, 21 involved the Moderna vaccine (15 males), and 15 involved the Pfizer-BioNTech vaccine (10 males).
And of the 49 cases recorded by March 10, 2021, 35 were in males, 26 involved the Moderna vaccine (20 males) and 23 involved the Pfizer-BioNTech vaccine (15 males).
The average age of the patients was 33.6 and median age was 31.5 — with the average age of male cases being 31.1 (median 28) and the average age of females 40.8 (median 36.5), indicating a higher incidence in younger males.
The average number of days before onset and diagnosis following vaccination was 5.4, with a median of 3 days.
With hundreds of pages’ worth of redactions, it is unclear if there are more documents or data that would provide further insights into the response provided by the agency to Israel’s Ministry of Health.
In its Feb. 24 response, the CDC claims the redacted documents are protected by statute, confidentiality laws or privacy laws.
Notably, on the same day as the Israel Ministry of Health’s request to the CDC, Pfizer published a document — released as part of last year’s “Pfizer Documents” release from the FDA — titled “Cumulative Analysis of Post-Authorization Adverse Event Reports of PF-07302048 (BNT162B2) received through 28-Feb-2021.”
BNT162B2 refers to the Pfizer-BioNTech COVID-19 vaccine that received Emergency Use Authorization from the FDA.
This document indicated that 25 cases of myocarditis were reported by Feb. 28, 2021 as part of a list of “adverse events of special interest” (AESI).
This figure drew from several databases, including the Brighton Collaboration (SPEAC), the EU’s ACCESS protocol, U.S. CDC (preliminary list of AESI for VAERS surveillance) and the UK’s Medicines and Healthcare Products Regulatory Agency.
Studies show COVID shots lead to increased risks of myocarditis
Several recent studies have shown an increased prevalence of myocarditis following COVID-19 vaccination.
“Delayed Vigilance: A Comment on Myocarditis in Association with the COVID-19 Injections,” by Karl Jablonowski, Ph.D. and Brian Hooker, Ph.D., P.E., published Oct. 17, 2022 in the International Journal of Vaccine Theory, Practice, and Research, found that two months after COVID-19 vaccines were rolled out to the public, a statistically significant safety signal for myocarditis in males ages 8 to 21 appeared in VAERS.
However, as previously reported by The Defender, even though this safety signal was visible as early as Feb. 19, 2021, CDC officials waited until May 27, 2021 before alerting the public.
By then, over 50% of the eligible U.S. population had received at least one mRNA COVID-19 vaccine — and the FDA expanded the EUA of the Pfizer-BioNTech vaccine to include adolescents 12 and older.
Another study, released April 15, 2022 by seven Israeli researchers, examined the incidence of myocarditis and pericarditis in adults previously were infected with COVID-19, between March 2020 and January 2021.
Despite arguments that an increase in myocarditis diagnoses may be attributed to COVID-19 infections instead of the vaccines, the study “did not observe an increased incidence of either pericarditis nor myocarditis in adult patients recovering from COVID-19 infection.”
As of March 3, 16,641 cases of myocarditis were recorded in VAERS following the receipt of a COVID-19 vaccine or booster — with the number growing to 16,660 when including diagnoses of bacterial myocarditis, infectious myocarditis, mycotic myocarditis, post-infection myocarditis and septic myocarditis.
Of the latter number, 10,701 cases (64.2%) were recorded in males.
While the age of over half of the patients in these recorded cases was listed as “unknown,” in cases where an age was recorded, myocarditis diagnoses peaked in the 18-29 year age group, with high prevalence also found in the 6-17 and 30-39 age groups.
Of 2,778 cases in the 18-29 age group, 2,211 were recorded in males — further indicating the particularly high risk of myocarditis young males face following COVID-19 vaccination.
More governments raising concerns about myocarditis
As early as October 2021, Sweden’s Public Health Agency paused Moderna’s COVID-19 vaccine for people born 1991 and later, “as data pointed to an increase of myocarditis and pericarditis among youths and young adults that had been vaccinated,” according to Reuters.
At around the same time, Finland’s public health authorities also paused the vaccine in young people.
And in November 2022, Sweden paused the Novavax COVID-19 vaccine for those under 30, due to an increased risk of myocarditis and pericarditis.
As reported by The Defender in June 2022, Novavax received EUA from the FDA despite “Multiple events of myocarditis/pericarditis” recorded during clinical trials.
Earlier this week, Yanagase Hirofumi, a member of Japan’s House of Councillors, accused the Japanese government of covering up injuries and deaths stemming from the mRNA COVID-19 vaccines.
Hirofumi told the House of Councillors that in Japan’s vaccine-related adverse events tracking system, at least 2,001 deaths following COVID-19 vaccination have been recorded.
BREAKING
The excess mortality caused by vaccination is making waves in the Japanese Diet.
In Japan, the number of deaths after vaccination has increased by 210,000 since 2020, the highest number since the World War II.
People are dying immediately after vaccination, and… https://t.co/0dDnDtJndf pic.twitter.com/03vB4BYaDR
— You (@You3_JP) March 13, 2023
However, despite “approximately 260 cases in which the doctor in charge reported that there was probably a link between the vaccine and the death” and, citing Japan’s health minister, “52 cases where a pathologist has performed an autopsy, and reported that there is a link between the vaccine and the death,” the database indicates that “only one case has been found to have a causal relationship between the vaccine and death.”
Hirofumi cited the example of “a man in his 30s” who “died three days after receiving the second dose of the vaccine. The cause of death was myocarditis,” adding that “ as a result of the autopsy, doctors concluded that there was a link between the vaccine and the death.”
In an interview on Sunday, Germany’s federal minister of health Karl Lauterbach — previously a proponent of a national vaccine mandate who had stated the COVID-19 vaccines had “no side effects” —admitted that serious adverse events were prevalent and that the vaccine injured are being ignored by the authorities.[/S]
Heliobas Disciple
TB Fanatic
COVID-19 News: SARS-CoV-2 Infections Rising Again In Australia, India, United Kingdom, Russia, Taiwan, Mexico, Japan, South Korea, Austria And Poland - Thailand Medical News
COVID-19 News: In the last 36 hours, the WHO had once again opened their mouths prematurely and said that the threat from COVID-19 would likely be reduced and be on par with that of flu and that the agency will likely be able to declare an end to the health emergency sometime in 2023...
www.thailandmedical.news
COVID-19 News: SARS-CoV-2 Infections Rising Again In Australia, India, United Kingdom, Russia, Taiwan, Mexico, Japan, South Korea, Austria And Poland
Thailand Medical News
March 18, 2023
In the last 36 hours, the WHO had once again opened their mouths prematurely and said that the threat from COVID-19 would likely be reduced and be on par with that of flu and that the agency will likely be able to declare an end to the health emergency sometime in 2023.
WHO Sees COVID Posing Similar Threat to Flu This Year
WHO chief hopes it will become simply a health challenge, but not a disruptive one
www.voanews.com
Interestingly in the same 36 hours, numerous reports and COVID-19 News coverages are emerging that SARS-CoV-2 infections and deaths are once are starting to rise in a number of countries including Australia, India, the United Kingdom, Taiwan, South Korea, Japan, Austria, Poland, Russia, Mexico, Canada and Philippines.
In Australia, there has been 22,289 new SARS-CoV-2 infections in the last 7 days with 1,125 individuals hospitalized and 24 in ICU due to COVID-19 and 107 COVID-19 deaths in the last 24 hours alone.
All the latest COVID-19 case numbers from around Australia — plus the news you may have missed
Here's a quick wrap of the COVID-19 news and case numbers from each Australian jurisdiction from the past week.
www.abc.net.au
It should be noted that there is very little testing in the country and in many states, true caseloads and deaths are being underreported.
Australian media are already warning that COVID-19 caseloads are increasing in South Australia and also in New South Wales.
COVID-19 cases jump by nearly 40 per cent in South Australia
South Australia has recorded a 37 per cent increase in the number of COVID-19 cases reported in the past week.
www.abc.net.au
Covid cases on the rise in NSW with a ‘patchwork quilt’ of variants
Experts say data points to early signs of a new wave but, given level of immunity, is not expected to be as severe as in the past
www.theguardian.com
India saw 796 new COVID-19 infections in the last 24 hours although actual figures could be as high as 7 to 8-fold as many states are not reporting actual figures coupled with limited testing as well.
Covid-19 cases see an uptick in India: active cases surpass 5,000 for first time in 109 days
According to the data, the number of active cases stood at 5,026 while the country recorded 5,30,795 deaths as on March 17.
indianexpress.com
H3N2 Influenza Cases in Pune: Covid-19 & H3N2 virus cases surge in Pune | Pune News - Times of India
Hospitals on Thursday confirmed a rise in respiratory illnesses, including those caused due to Covid-19, H1N1 and H3N2 infections. Doctors said among
timesofindia.indiatimes.com
https://indianexpress.com/article/c...7-new-covid-19-cases/articleshow/98737839.cms"
Goa records 17 new Covid-19 cases | Goa News - Times of India
With there being a slight rise in coronavirus cases, the health services want people to follow Covid-appropriate behaviour if they visit places that a
timesofindia.indiatimes.com
Tamil Nadu records 49 new cases of Covid-19 | Chennai News - Times of India
The state-reported 49 new Covid-19 cases taking the tally of active cases to 284. There were 14 Covid-19 patients in hospitals. None of them required
timesofindia.indiatimes.com
In the United Kingdom, the Zoe app showed more than 127,000 symptomatic COVID-19 cases in the last 24 hours.
Latest Daily UK COVID-19 Data: Vaccines, Cases, Trends | ZOE
COVID infection & vaccination rates in the UK today, based on public data and reports from millions of users of the ZOE Health Study app
health-study.joinzoe.com
Daily COVID-19 deaths averaged about 110 in the last few days and hospitalizations are rising once more again.
View: https://twitter.com/LawrenceGilder/status/1636435312204185602
It is also interesting to note that excess deaths are rising in the United Kingdom.
View: https://twitter.com/1goodtern/status/1635948936119611393
Canada is also reporting a rise in COVID-19 infection and hospitalizations but more so in British Columbia and on Nova Scotia.
COVID-19 hospitalizations rise in latest B.C. update, led by Fraser Health
The B.C. Centre for Disease Control reported 222 people in hospital with COVID-19 Thursday, a modest increase from the 205 seen last week.
Parts of Philippines are also witnessing the start of a new SARS-CoV-2 onslaught.
COVID-19 positivity rate in NCR climbs to 3% — OCTA
The COVID-19 positivity rate in the National Capital Region (NCR) climbed to 3% as of March 15, according to independent monitoring group OCTA Research on Friday.
Various countries including Taiwan, South Korea, Russia, Poland, Austria, Mexico are all witnessing new rise in COVID-19 infections.
Coronavirus Update (Live): 127,455,505 Cases and 2,791,707 Deaths from COVID-19 Virus Pandemic - Worldometer
Live statistics and coronavirus news tracking the number of confirmed cases, recovered patients, tests, and death toll due to the COVID-19 coronavirus from Wuhan, China. Coronavirus counter with new cases, deaths, and number of tests per 1 Million population. Historical data and info. Daily...
At present there are more than 1000 different SARS-CoV-2 sub-lineages and recombinant variants that have emerged in the last few months with many in circulation. Researchers do not even have details about the pathogenicity and virulence of many of these new sub-lineages.
covSPECTRUM
covSPECTRUM is an interactive platform aiming to help scientists investigate and identify variants of SARS-CoV-2.
cov-spectrum.org
Media reports have also emerged in the last 24 hours about Israel discovering a possible new recombinant SARS-CoV-2 variant.
Israel records 2 cases of unidentified new Covid variant: What we know so far
New Covid Variant In Israel: The patients underwent an RT-PCR test upon landing at Ben-Gurion International airport after which they tested positive.
Unfortunately, most people are still being brainwashed into the fallacy that COVID-19 is now mild and endemic and that there is nothing to be worried about.
What is even more worrisome is that many millennials and Gen Zers that I have come across do not even know what Long COVID is or are not even aware that some of the health issues that they are having could be due to Long COVID!
While new onslaughts of SARS-CoV-2 continue silently in many geolocations across the world, we can expect reinfections and coinfections to drive the excess deaths rates in coming months.
Heliobas Disciple
TB Fanatic
btw, that's now a trending story. It was so ridiculous I didn't want to post it, so posted the Gateway Pundit's story about it instead. But look at all who are now reporting this as the 'truth'... and this is just a sample. Do you think the MSM was told to publish this story to help Fauci and to debunk the recent studies that it was a lab leak (which incidentally the majority of people now believe it was a lab leak according to recent polling, see next article)
New COVID origins data point to raccoon dogs in China market
The mystery to the origins of the COVID-19 pandemic now has some new clues. International scientists have found raccoon dog DNA comingled with the virus in previously unavailable genetic data.
New Data Links Pandemic’s Origins to Raccoon Dogs at Wuhan Market
Genetic samples from the market were recently uploaded to an international database and then removed after scientists asked China about them.
The Strongest Evidence Yet That an Animal Started the Pandemic
A new analysis of genetic samples from China appears to link the pandemic’s origin to raccoon dogs.
New data links Covid-19’s origins to raccoon dogs at Wuhan market
Analysis of gene sequences by international team finds Covid-positive samples rich in raccoon dog DNA
New report suggests COVID pandemic's origins linked to raccoon dogs at Wuhan market
A new report from a team of international researchers suggests the COVID pandemic's origins may be linked to raccoon dogs that were being sold at a wet market in Wuhan.
New Covid origins data suggests pandemic linked to raccoon dogs at Wuhan market
The samples were collected from surfaces at the Huanan seafood market in Wuhan after the first human cases of Covid-19 were found in late 2019.
New genetic analysis finds clues to animal origin of COVID outbreak
Analysis presented to the WHO offers clues to whether animals, possibly raccoon dogs, were infected at the Huanan animal market in early 2020.
Genetic Data Links Covid Origins To Raccoon Dogs Sold At Wuhan Wet Market, Reports Say
This finding is the first piece of genetic evidence linking an animal being sold at the wet market to the coronavirus that caused the pandemic.
They are really not letting this go....
WHO, advisors urge China to release all COVID-related data after new research
New sequences of the SARS-CoV-2 virus as well as additional genomic data based on samples taken from a live animal market in Wuhan, China in 2020 were briefly uploaded to the GISAID database by Chinese scientists earlier this year, allowing them to be viewed by researchers in other countries...
WHO, advisors urge China to release all COVID-related data after new research
by Sneha Bhowmik in Bengaluru and Jennifer Rigby in London
Sat, March 18, 2023, 2:56 PM EDT
(Reuters) -Advisors to the World Health Organization on Saturday urged China to release all information related to the origin of the COVID-19 pandemic after new findings were briefly shared on an international database used to track pathogens.
New sequences of the SARS-CoV-2 virus as well as additional genomic data based on samples taken from a live animal market in Wuhan, China in 2020 were briefly uploaded to the GISAID database by Chinese scientists earlier this year, allowing them to be viewed by researchers in other countries, according to the statement from the WHO's Scientific Advisory Group for the Origins of Novel Pathogens (SAGO).
The sequences suggested that raccoon dogs were present in the market and may have also been infected by the coronavirus, providing a new clue in the chain of transmission that eventually reached humans.
Access to the information was subsequently restricted “apparently to allow further data updates” by the Chinese Center for Disease Control and Prevention (CDC).
WHO officials discussed the matter with Chinese colleagues, who explained that the new data were intended to be used to update a preprint study from 2022. China's CDC plans to re-submit the paper to the scientific journal Nature for publication, according to the statement.
WHO officials say such information, while not conclusive, represents a new lead into the investigation of COVID's origins and should have been shared immediately.
"These data do not provide a definitive answer to the question of how the pandemic began, but every piece of data is important in moving us closer to that answer," WHO Director-General Tedros Adhanom Ghebreyesus said on Friday. "These data could have – and should have – been shared three years ago."
"We continue to call on China to be transparent in sharing data, and to conduct the necessary investigations and share the results," he said.
SAGO was tasked by the WHO to continue to investigate the origins of the pandemic that has killed nearly 7 million people worldwide.
"(This is) newly analysed data and nothing new," said George Gao, professor at the Institute of Microbiology at the CDC, when asked by Reuters why the sequences were not uploaded before. He said that GISAID, the pathogen database, took down the sequences, not the scientists.
"All this must be left for scientists to work on，NOT for journalists or public. We are eager to know the answer," he added in an emailed statement.
The Huanan Seafood Wholesale Market in Wuhan was shut down by Chinese authorities after the novel coronavirus emerged in the city in late 2019. The market has since been a focus of study of whether the virus had infected several other species before jumping to humans.
The WHO and other scientists have also said they cannot rule out the possibility that the virus emerged from a high-security laboratory in Wuhan that studies dangerous pathogens. China denies any such link.
The 2022 preprint paper said that a small portion of 923 samples collected from the stalls and sewage systems in and around the market tested positive for the virus; no virus was detected in 457 animal samples tested. The paper said initially that raccoon dogs were not among the animals tested.
The new analysis suggests "that raccoon dog and other animals may have been present before the market was cleaned as part of the public health intervention," the SAGO statement said.
Heliobas Disciple
TB Fanatic
COVID-19 Vaccines Can Cause 'Permanent Disabilities,' Says German Health Minister | ZeroHedge
ZeroHedge - On a long enough timeline, the survival rate for everyone drops to zero
www.zerohedge.com
COVID-19 Vaccines Can Cause 'Permanent Disabilities,' Says German Health Minister
by Tyler Durden
Saturday, Mar 18, 2023 - 08:10 AM
Authored by Lorenz Duchamps via The Epoch Times (emphasis ours),
Germany’s Minister of Health Karl Lauterbach, who once claimed that COVID-19 vaccination is free of side effects, admitted last week that he was wrong, saying adverse reactions occur at a rate of one in 10,000 doses and can cause “severe disabilities.”
On Aug. 14, 2021, Lauterbach said on Twitter that the vaccines had “no side effects,” further questioning why some Germans refused to get vaccinated against COVID-19.
During an interview on ZDF’s “Heute Journal” on March 12, Lauterbach was asked by anchor Christian Sievers about the claim he made in the summer of 2021, confronting the health minister with his previous tweet that stated the shots are virtually free of side effects.
Lauterbach responded that the tweet was “misguided” and an “exaggeration” he made at the time, noting that it “did not represent my true position.”
“I’ve always been aware of the numbers and they’ve remained relatively stable … one in 10,000 [are injured],” Lauterbach said. “Some say that it’s a lot, and some say it’s not so many.”
Lauterbach’s remark on vaccine adverse events came after the German network played a segment of several Germans who’ve been seriously injured after getting the shot, including a 17-year-old gymnast who previously competed in the German Artistic Gymnastics Championships before she was hospitalized for more than one year shortly after receiving the second dose of the BioNTech COVID-19 vaccine.
“What do you say to those who have been affected [by vaccine injuries]?” Sievers asked Lauterbach.
“What’s happened to these people is absolutely dismaying, and every single case is one too many,” Lauterbach responded. “I honestly feel very sorry for these people. There are severe disabilities, and some of them will be permanent.”
Steve Kirsch, executive director of the Vaccine Safety Research Foundation, did not agree with Lauterbach, but he commended the health minister for making “progress” when comparing his latest remark to his previous comments regarding the safety and effectiveness of COVID-19 vaccines.
“The true rate of serious adverse events is approximately 100 times greater than the figures Lauterbach cited—’closer to 1 in 100 doses’ and ‘For death, it is ~1 in 1,000 doses,'” Kirsch said on Twitter.
By Oct. 31, 2022, the Paul-Ehrlich-Institut received a total of 333,492 individual case reports on suspected COVID-19 vaccine adverse reactions or vaccine side effects in Germany, according to official data (pdf) released in December 2022 by the medical regulatory body that researches vaccines and biomedicines.
“The number of individual case reports per month peaked in December 2021 and continued through the summer,” according to the federal agency, which is subordinate to the German Ministry of Health.
Despite these findings, the country’s health ministry website states, as of March 16, that “modern vaccines are safe and adverse effects only occur in sporadic cases.”
Lawsuits Pending
As the subject of post-vaccine injuries has started to be more widely covered by some German media outlets, lawsuits have begun to roll out against BioNTech, and also against other COVID-19 vaccine manufacturers.BioNTech has denied all responsibilities, ZDF reported.
Vaccine manufacturers such as Pfizer and Moderna have immunity from liability if something unintentionally goes wrong with their vaccines, putting them in a very strong legal position.
“It’s true that within the framework of these EU contracts, the companies were largely exempted from liability and that the liability, therefore, lies with the German state,” Lauterbach said.
Read more here...
Heliobas Disciple
TB Fanatic
OMG, seriously?!?!? This is what they are researching now???
(fair use applies)
UFO Sightings and COVID-19 Pandemic Link Tested in Surprising New Research
By Society for Scientific Exploration
March 18, 2023
A recent article published in the Journal of Scientific Exploration investigated whether the COVID-19 pandemic was associated with an increase in UFO sightings. The authors hypothesized that lockdowns and social distancing measures may have led to an increase in available free time and heightened attention to the environment, resulting in more UFO sightings. However, their analysis demonstrated that while UFO reports did increase in 2020 compared to the previous year, there was no association between the number of reports and social factors like the pandemic. The authors identified the initiation of regular launches of Starlink satellites as a complicating factor, which often get reported as UFOs. The study suggests that future research should investigate other factors that may influence UFO reporting.
Have you ever wondered if social factors like pandemics can affect UFO reporting? In a recent article published in the Journal of Scientific Exploration, authors Chase Cockrell from the University of Vermont, and Mark Rodeghier and Linda Murphy from the Center for UFO Studies, investigated whether the COVID-19 pandemic was associated with an increase in UFO sightings.
The authors hypothesized that the COVID-19 pandemic, which resulted in lockdowns and social distancing measures, may have led to an increase in UFO sightings. The reasoning behind this hypothesis was that with more people staying home and spending time outdoors, there may have been an increase in available free time, which could result in more UFO sightings. Additionally, the authors tested the idea that increased feelings of anxiety and uncertainty may have led to heightened attention to the environment, which could have caused people to more often notice unusual phenomena and make sense of what they experienced by connecting it with UFOs.
The authors analyzed data from the National UFO Reporting Center (NUFORC) and the Mutual UFO Network (MUFON), the two most comprehensive UFO reporting sites in the United States, from 2018 through 2020 and compared the number of UFO reports before and after the start of the pandemic. To test whether social factors could have influenced the number of reports, they used publicly available data for social mobility from Google Community Mobility Reports, and SARS-CoV-2 cases and deaths, which are indirect measures of stress and anxiety.
Their analysis demonstrated that UFO reports did increase in 2020 compared to the previous year by about 600 reports in each database. However, there was no association between the number of reports—aggregated across the US or by state—with the mobility and pandemic health measures, providing no support that social factors led to increased reports.
The researchers then searched for alternative causes and identified the initiation of regular launches of Starlink satellites beginning in late 2019 as a complicating factor. These launches include up to 60 small satellites at once, which are very distinctive and often easily visible. As a result, many people understandably reported these as UFOs. The analysis demonstrated a relationship between a launch and subsequent reports. After removing these reports, they retested the association with the social and pandemic-health factors, but again found no relationship. Critically, with the Starlink reports removed, there was no statistical increase in reports in 2020, and even a decrease in reports to NUFORC.
The astronomical community is concerned about the impact of Starlink, and other similar projects, launching large numbers of satellites in relatively low orbits and potentially degrading astronomical measurements. The authors demonstrated that the UFO community has a similar problem.
“This study sheds light on the potential impact of social factors on UFO reporting,” says Mark Rodeghier, Scientific Director of the Center for UFO Studies. While they found that the COVID-19 pandemic did not significantly impact UFO reporting, their findings suggest that future research should investigate other factors that may influence reporting.
Reference: “Social factors and UFO reports: Was the SARS-CoV-2 pandemic associated with an increase in UFO reporting?” by R Chase Cockrell, Linda Murphy and Mark Rodeghier, 11 February 2023, Journal of Scientific Exploration.
DOI: 10.31275/20222681
UFO Sightings and COVID-19 Pandemic Link Tested in Surprising New Research
Have you ever wondered if social factors like pandemics can affect UFO reporting? In a recent article published in the Journal of Scientific Exploration, authors Chase Cockrell from the University of Vermont, and Mark Rodeghier and Linda Murphy from the Center for UFO Studies, investigated whether t
scitechdaily.com
UFO Sightings and COVID-19 Pandemic Link Tested in Surprising New Research
By Society for Scientific Exploration
March 18, 2023
A recent article published in the Journal of Scientific Exploration investigated whether the COVID-19 pandemic was associated with an increase in UFO sightings. The authors hypothesized that lockdowns and social distancing measures may have led to an increase in available free time and heightened attention to the environment, resulting in more UFO sightings. However, their analysis demonstrated that while UFO reports did increase in 2020 compared to the previous year, there was no association between the number of reports and social factors like the pandemic. The authors identified the initiation of regular launches of Starlink satellites as a complicating factor, which often get reported as UFOs. The study suggests that future research should investigate other factors that may influence UFO reporting.
Have you ever wondered if social factors like pandemics can affect UFO reporting? In a recent article published in the Journal of Scientific Exploration, authors Chase Cockrell from the University of Vermont, and Mark Rodeghier and Linda Murphy from the Center for UFO Studies, investigated whether the COVID-19 pandemic was associated with an increase in UFO sightings.
The authors hypothesized that the COVID-19 pandemic, which resulted in lockdowns and social distancing measures, may have led to an increase in UFO sightings. The reasoning behind this hypothesis was that with more people staying home and spending time outdoors, there may have been an increase in available free time, which could result in more UFO sightings. Additionally, the authors tested the idea that increased feelings of anxiety and uncertainty may have led to heightened attention to the environment, which could have caused people to more often notice unusual phenomena and make sense of what they experienced by connecting it with UFOs.
The authors analyzed data from the National UFO Reporting Center (NUFORC) and the Mutual UFO Network (MUFON), the two most comprehensive UFO reporting sites in the United States, from 2018 through 2020 and compared the number of UFO reports before and after the start of the pandemic. To test whether social factors could have influenced the number of reports, they used publicly available data for social mobility from Google Community Mobility Reports, and SARS-CoV-2 cases and deaths, which are indirect measures of stress and anxiety.
Their analysis demonstrated that UFO reports did increase in 2020 compared to the previous year by about 600 reports in each database. However, there was no association between the number of reports—aggregated across the US or by state—with the mobility and pandemic health measures, providing no support that social factors led to increased reports.
The researchers then searched for alternative causes and identified the initiation of regular launches of Starlink satellites beginning in late 2019 as a complicating factor. These launches include up to 60 small satellites at once, which are very distinctive and often easily visible. As a result, many people understandably reported these as UFOs. The analysis demonstrated a relationship between a launch and subsequent reports. After removing these reports, they retested the association with the social and pandemic-health factors, but again found no relationship. Critically, with the Starlink reports removed, there was no statistical increase in reports in 2020, and even a decrease in reports to NUFORC.
The astronomical community is concerned about the impact of Starlink, and other similar projects, launching large numbers of satellites in relatively low orbits and potentially degrading astronomical measurements. The authors demonstrated that the UFO community has a similar problem.
“This study sheds light on the potential impact of social factors on UFO reporting,” says Mark Rodeghier, Scientific Director of the Center for UFO Studies. While they found that the COVID-19 pandemic did not significantly impact UFO reporting, their findings suggest that future research should investigate other factors that may influence reporting.
Reference: “Social factors and UFO reports: Was the SARS-CoV-2 pandemic associated with an increase in UFO reporting?” by R Chase Cockrell, Linda Murphy and Mark Rodeghier, 11 February 2023, Journal of Scientific Exploration.
DOI: 10.31275/20222681
Heliobas Disciple
TB Fanatic
Another great video from David Martin.
This one starts off with more of his background. Skip to around 43 minutes for the covid patent info.
It’s Much Worse Than You Think, Govt Corruption And The Creation Of Covid w/ David E. Martin, PhD
The Kim Iversen Show LIVE | March 17, 2023 Dr. David Martin PhD founder of M·CAM® and has published across various fields in law, medicine, engineering, finance, and education. He recently appeared in
rumble.com
It’s Much Worse Than You Think, Govt Corruption And The Creation Of Covid w/ David E. Martin, PhD
The Kim Iversen Show LIVEStreamed on:Mar 17, 9:00 pm EDT
Dr. David Martin PhD founder of M·CAM® and has published across various fields in law, medicine, engineering, finance, and education. He recently appeared in Mikki Willis’ documentary, Plandemic: Indoctornation where he revealed the truth behind the vaccine agenda and how following the money had led him to a number of conclusions about what is really going on during the Coronavirus crisis. He joins us today to discuss his experience uncovering government corruption.
Heliobas Disciple
TB Fanatic
Zerohedge
ZeroHedge - On a long enough timeline, the survival rate for everyone drops to zero
www.zerohedge.com
'Conspiracy At Its Height': Fauci Responds To Message Saying He 'Prompted' Anti-Lab Leak Paper
by Tyler Durden
Saturday, Mar 18, 2023 - 10:30 PM
Authored by Zachary Stieber via The Epoch Times (emphasis ours),
Dr. Anthony Fauci responded on March 15 to a newly released email that said he was among those who “prompted” work on analyzing how COVID-19 came about, which resulted in a paper that claimed the laboratory origin theory was not credible.
A special U.S. House of Representatives panel on March 5 released the email, sent by scientist Kristian Andersen in February 2020 to the journal Nature.
“There has been a lot of speculation, fear mongering, and conspiracies put forward in this space and we thought that bringing some clarity to this discussion might be of interest to Nature,” Andersen wrote at the time. “Prompted by Jeremy Farra[r], Tony Fauci, and Francis Collins, Eddie Holmes, Andrew Rambaut, Bob Garry, Ian Lipkin, and myself have been working through much of the (primarily) genetic data to provide agnostic and scientifically informed hypothesis around the origins of the virus,” Andersen added.
In another message that had previously been made public, Andersen said the work was “focused on trying to disprove any type of lab theory.”
Anderson was one of the co-authors of a paper published without peer review in February 2020. Both that version and one later published by Nature Medicine said the analysis shows that “SARS-CoV-2 is not a laboratory construct nor a purposefully manipulated virus.” SARS-CoV-2 causes COVID-19.
Fauci was asked about the emails on Wednesday during an appearance on NewsNation.
“Absolutely not,” he said when host Chris Cuomo inquired whether the paper was drafted to disprove the lab origin theory.
Fauci referenced the secret phone call involving himself, Andersen, and others that took place on Feb. 1, 2020, and involved several experts—including Andersen—saying characteristics of COVID-19 pointed to it being engineered.
“During the phone call on Feb. 1, where very competent evolutionary biologists were going back and forth, and they decided on the phone call, listen, let’s take a little time and go back and really carefully examine those sequences and see if, in fact, there’s anything to that,” Fauci said.
“They did that and they came to the conclusion that, in fact, it is more likely that it was not something that was engineered, but something that actually escaped from a wet market [in Wuhan, China]. And in order to get it peer reviewed, they wrote a paper to let the peer review system evaluate whether it was valid, and it did and that’s how the paper came about,” Fauci added. “So this idea of saying, write the paper to definitively disprove something is conspiracy at its height. It’s really ridiculous.”
Grateful for ‘Advice and Leadership’
According to other emails made public after being acquired through the Freedom of Information Act, Fauci was involved in looking over drafts of the paper before it was published. In one email, Andersen thanked Fauci and several others “for your advice and leadership as we have been working through the SARS-CoV-2 ‘origins’ paper.”“Thanks for your note. Nice job on the paper,” Fauci responded.
Fauci’s boss, Dr. Francis Collins, was also thanked. In a later email to Fauci, he said that the lab origin theory was “very destructive” and that he had hoped the paper “would settle this” but that it “probably didn’t get much visibility.”
“I would not do anything about this right now. It is a shiny object that will go away in times,” Fauci wrote. In April 2020, Fauci cited the paper during an official White House press conference without mentioning his involvement, telling reporters that “a group of highly qualified evolutionary virologists looked at the sequences there and the sequences in bats as they evolve and the mutations that it took to get to the point where it is now is totally consistent with a jump of a species from an animal to a human.”
For the natural origin theory to be true, a host animal must have passed the virus on to humans. No such animal has been identified.
Fauci has maintained during recent interviews that he’s kept an open mind as to the origin of COVID-19.
“If that is true, why did Dr. Fauci tell the American people at a White House briefing televised on April 17, 2020, that COVID-19 was ‘totally consistent’ with a natural origin and never mentioned that half the scientists on a February 1, 2020, conference call thought it was a lab leak,” Rep. Debbie Lesko (R-Ariz.), a member of the special U.S. House panel, the Select Subcommittee on the Coronavirus Pandemic, told The Epoch Times via email.
“That doesn’t sound like someone with an open mind. That sounds like someone misleading the American public,” Lesko added.
Read more here...
[screengrabs of the rest of the article if you can't access it - click on the images]
Heliobas Disciple
TB Fanatic
'Six smoking guns': Why doctor-turned-US-senator believes COVID-19 came from Wuhan lab
Sen. Roger Marshall (R-Kan.) had pointed to a lab leak at the Wuhan Institute of Virology long before the FBI and other intel agencies.
justthenews.com
'Six smoking guns': Why doctor-turned-US-senator believes COVID-19 came from Wuhan lab
Sen. Roger Marshall (R-Kan.) had pointed to a lab leak at the Wuhan Institute of Virology long before the FBI and other intel agencies.
By John Solomon
Updated: March 20, 2023 - 12:51am
Long before key components of the intelligence community acknowledged they believed COVID-19 came from a lab leak, Kansas Republican Sen. Roger Marshall had drawn a bull's-eye around the Wuhan Institute of Virology.
Marshall, a doctor turned politician, argued early and often that the virus' emergence and genetic characteristics did not seem like those of a naturally evolving animal-to-human virus. But senators like him and Kentucky Republican Rand Paul were marginalized and even demeaned early on by detractors ranging from Dr. Anthony Fauci to TV comedian Stephen Colbert.
Today, Marshall's analysis is gaining widespread acceptance, as the the FBI, House Intelligence Committee and Energy Department have all concluded the most likely source of the pandemic was a leak from the Wuhan research lab.
China and the lab continue to deny such allegations. But even Fauci, who pressed often to portray the virus as naturally evolving from wild animals, has begun to change his tune, saying he has an open mind while still suspecting natural evolution.
"A lab leak could be that someone was out in the wild, maybe looking for different types of viruses in bats, got infected, went into a lab, and was being studied in a lab, and then came out of the lab," Fauci said last week on CNN. "But if that's the definition of lab leak, then that's still a natural occurrence.
"The other possibility is someone takes a virus from the environment that doesn't actually spread very well in humans, and manipulates it a bit, and accidentally it escapes or accidentally infects someone and then you get an outbreak."
Some researchers continue to press the idea of natural evolution, most recently last week with a suggestion the virus leapt from raccoon dogs.
In a wide-ranging interview last week, Marshall described the "six smoking guns" that led him to believe the virus emerged from an accident at the WIV, a lab in Wuhan closely tied to the Chinese military's Academy of Military Medical Sciences, which the State Department first identified in 2005 as a home to an illicit offensive bioweapons program run by Beijing.
"There's just too many coincidences," the senator declared in an interview with the John Solomon Reports podcast.
Here are the six factors Marshall said convinced him the virus came from a lab leak at WIV:
1. The proximity of the lab to the initial outbreak: "There's only three labs in the world doing research on this type of virus," Marshall said, "and this virus breaks out right next to it, a thousand miles away from where that virus is supposed to be" located in a cave of bats. "That's smoking gun number one."
2. No intermediate species: After three years, Marshall noted, China is still unable to "show that there's an intermediate species" via which the virus passed in its leap from bats to humans. "I'm a biochemistry major, nuclear engineering, physician — I get the science, I've always got the science of it," Marshall said, explaining that the virus "should have jumped from bats to some type of an animal and then to humans."
3. The virus' protein spike: The protein spike's ability to extraordinarily and preferentially bind to human lung cells over bats points directly to genetic lab engineering, Marshall said. Researchers have found that a sequence of eight amino acids on a critical part of the virus' spike protein is identical to an amino acid sequence found in cells that line human airways.
4. Furin cleavage site: "The furin cleavage site would be the fourth smoking gun: a perfect junction at the S1/S2 part of this virus that the human lung cells just happened to have the cleaver in there to cleave it, so it dumps its genetic information into you," Marshall said.
Nobel laureate David Baltimore agrees. "When I first saw the furin cleavage site in the viral sequence, with its arginine codons, I said to my wife it was the smoking gun for the origin of the virus," he said, according to the New York Post.
"These features make a powerful challenge to the idea of a natural origin for SARS2," he said.
5. Database deletion: China deleted a key DNA database from its COVID research. In September 2019, the Wuhan Institute of Virology takes its entire genomic data bank offline, keeping it from the rest of the world just before the outbreak, Marshall said.
6. Lack of natural progenitor: No progenitor to COVID-19 has been found showing its natural ancestry. "We've never found that progenitor," the senator said. "There should be a cousin, a grandfather, an uncle of COVID-19. And we've never found it."
Marshall said the mathematical chance a virus evolved with these coincidences is astronomically small. "Your six coincidental events is one in a million each, and that just happened to work perfectly for this virus," he said.
The House Intelligence Committee in December and the Senate Health Committee Republicans in September came to similar conclusions. You can read their reports here:
COVID-19 origins report
final_unclass_summary_-_covid_origins_report_-_dec._2022.pdf
naegling62
Veteran Member
So why does his security have to wear a mask outdoors?
Heliobas Disciple
TB Fanatic
Biden signs bill on COVID origins declassification
WASHINGTON (AP) — President Joe Biden signed a bipartisan bill Monday that directs the federal government to declassify as much intelligence as possible about the origins of COVID-19 more than three years after the start of the pandemic.
apnews.com
Biden signs bill on COVID origins declassification
yesterday
WASHINGTON (AP) — President Joe Biden signed a bipartisan bill Monday that directs the federal government to declassify as much intelligence as possible about the origins of COVID-19 more than three years after the start of the pandemic.
The legislation, which passed both the House and Senate without dissent, directs the Office of the Director of National Intelligence to declassify intelligence related to China’s Wuhan Institute of Virology. It cites “potential links” between the research that was done there and the outbreak of COVID-19, which the World Health Organization declared a pandemic on March 11, 2020. The law allows for redactions to protect sensitive sources and methods.
U.S. intelligence agencies are divided over whether a lab leak or a spillover from animals is the likely source of the deadly virus. Experts say the true origin of the coronavirus pandemic, which has killed more than 1.1 million in the U.S. and millions more around the globe, may not be known for many years — if ever.
Biden, in a statement, said he was pleased to sign the legislation.
“My Administration will continue to review all classified information relating to COVID–19’s origins, including potential links to the Wuhan Institute of Virology,” he said. “In implementing this legislation, my Administration will declassify and share as much of that information as possible, consistent with my constitutional authority to protect against the disclosure of information that would harm national security.”
Heliobas Disciple
TB Fanatic
“Glow-in-the-Dark” Proteins: The Future of Viral Disease Detection?
Although there have been significant advancements in diagnostic tests for viral diseases, many highly sensitive tests still rely on complex sample preparation and result interpretation methods, rendering them unsuitable for point-of-care settings or resource-limited areas. However, researchers have
scitechdaily.com
“Glow-in-the-Dark” Proteins: The Future of Viral Disease Detection?
By American Chemical Society
March 21, 2023
Although there have been significant advancements in diagnostic tests for viral diseases, many highly sensitive tests still rely on complex sample preparation and result interpretation methods, rendering them unsuitable for point-of-care settings or resource-limited areas. However, researchers have now revealed in ACS Central Science a novel, sensitive technique that can analyze viral nucleic acids in just 20 minutes using a one-step process with “glow-in-the-dark” proteins.
Bioluminescence, the scientific phenomenon behind the firefly’s glow, the anglerfish’s radiant lure, and the ghostly blue of phytoplankton-laden shores, is powered by a chemical reaction involving the luciferase protein. This luminescent protein has been integrated into sensors that emit visible light when detecting their target, making them ideal for straightforward point-of-care testing. However, until now, these sensors have not achieved the exceptional sensitivity necessary for clinical diagnostic tests.
The gene-editing technique known as CRISPR could provide this ability, but it requires many steps and additional specialized equipment to detect what can be a low signal in a complex, noisy sample. So, Maarten Merkx and colleagues wanted to use CRISPR-related proteins, but combine them with a bioluminescence technique whose signal could be detected with just a digital camera.
To make sure there was enough sample RNA or DNA to analyze, the researchers performed recombinase polymerase amplification (RPA), a simple method that works at a constant temperature of about 100 F. With the new technique, called LUNAS (luminescent nucleic acid sensor), two CRISPR/Cas9 proteins specific for different neighboring parts of a viral genome each have a distinct fragment of luciferase attached to them.
If a specific viral genome that the researchers were testing for was present, the two CRISPR/Cas9 proteins would bind to the targeted nucleic acid sequences and come close to each other, allowing the complete luciferase protein to form and shine blue light in the presence of a chemical substrate. To account for this substrate being used up, the researchers used a control reaction that shined green. A tube that changed from green to blue indicated a positive result.
When tested on clinical samples collected from nasal swabs, RPA-LUNAS successfully detected SARS-CoV-2 RNA within 20 minutes, even at concentrations as low as 200 copies per microliter. The researchers say that the LUNAS assay has great potential for detecting many other viruses effectively and easily.
Reference: “Glow-in-the-Dark Infectious Disease Diagnostics Using CRISPR-Cas9-Based Split Luciferase Complementation” by Harmen J. van der Veer, Eva A. van Aalen, Claire M. S. Michielsen, Eva T. L. Hanckmann, Jeroen Deckers, Marcel M. G. J. van Borren, Jacky Flipse, Anne J. M. Loonen, Joost P. H. Schoeber and Maarten Merkx, 15 March 2023, ACS Central Science.
DOI: 10.1021/acscentsci.2c01467
The study was funded by the Dutch Research Council | Nationaal Regieorgaan Praktijkgericht Onderzoek SIA (NRPO-SIA) and the Eindhoven University Fund.
Heliobas Disciple
TB Fanatic
Three Years To Slow The Spread: COVID Hysteria & The Creation Of A Never-Ending Crisis | ZeroHedge
ZeroHedge - On a long enough timeline, the survival rate for everyone drops to zero
www.zerohedge.com
Three Years To Slow The Spread: COVID Hysteria & The Creation Of A Never-Ending Crisis
by Tyler Durden
Tuesday, Mar 21, 2023 - 06:05 PM
Authored by Jordan Schachtel via 'The Dossier' Substack,
Last Thursday marked the three year anniversary of the infamous “15 Days To Slow The Spread” campaign.
By March 16, yours truly was already pretty fed up with both the governmental and societal “response” to what was being baselessly categorized as the worst pandemic in 100 years, despite zero statistical data supporting such a serious claim.
The Moment That Shook the World: "15 Days to Slow the Spread" (March 16, 2020)
Fauci: "In states with evidence of community transmission, bars, restaurants, food courts, gyms, and other indoor and outdoor venues where groups of people congregate should be https://t.co/T9CGrYFNjv… https://t.co/SwDYBgN438 pic.twitter.com/k5oaU36YAR
— The Vigilant Fox (@VigilantFox) March 16, 2023
I was living in the Washington, D.C. Beltway at the time, and it was pretty much impossible to find a like-minded person within 50 miles who also wasn’t taking the bait. After I read about the news coming out of Wuhan in January, I spent much of the next couple weeks catching up to speed and reading about what a modern pandemic response was supposed to look like.
What surprised me most was that none of “the measures” were mentioned, and that these designated “experts” were nothing more than failed mathematicians, government doctors, and college professors who were more interested in policy via shoddy academic forecasting than observing reality.
Within days of continually hearing their yapping at White House pressers, It quickly became clear that the Deborah Birx’s and Anthony Fauci’s of the world were engaging in nothing more than a giant experiment. There was no an evidence-based approach to managing Covid whatsoever. These figures were leaning into the collective hysteria, and brandishing their credentials as Public Health Experts to demand top-down approaches to stamping out the WuFlu.
DeSantis on Covid lockdowns: “So I call and say, ‘Deborah [Birx], tell me: when in American history has this been done?’ And she says, ‘It’s kind of our own science experiment that we’re doing in real time.’”
Lockdowns were Fauci's “science experiment”pic.twitter.com/K7H8NIBPaV
— Dr. Eli David (@DrEliDavid) March 14, 2023
To put it bluntly, these longtime government bureaucrats had no idea what the f—k they were doing. Fauci and his cohorts were not established or reputable scientists, but authoritarians, charlatans, who had a decades-long track record of hackery and corruption. This Coronavirus Task Force did not have the collective intellect nor the wisdom to be making these broad brush decisions.
Back then, there were only literally a handful of people who attempted to raise awareness about the wave of tyranny, hysteria, and anti-science policies that were coming our way. There were so few of us back in March in 2020 that it was impossible to form any kind of significant structured resistance to the madness that was unfolding before us. These structures would later form, but not until the infrastructure for the highway to Covid hysteria hell had already been cemented.
Making matters worse was the reality that the vast majority of the population — friends, colleagues, peers and family included — agreed that dissenters were nothing more than reckless extremists, bioterrorists, Covid deniers, anti-science rabble rousers, and the like.
Yet we were right, and we had the evidence and data to prove it. There was no evidence to ever support such a heavy-handed series of government initiatives to “slow the spread.”
By March 16, 2020, data had already accumulated indicating that this contagion would be no more lethal than an influenza outbreak.
The February, 2020 outbreak on the Diamond Princess cruise ship provided a clear signal that the hysteria models provided by Bill Gates-funded and managed organizations were incredibly off base. Of the 3,711 people aboard the Diamond Princess, about 20% tested positive with Covid. The majority of those who tested positive had zero symptoms. By the time all passengers had disembarked from the vessel, there were 7 reported deaths on the ship, with the average age of this cohort being in the mid 80s, and it wasn’t even clear if these passengers died from or with Covid.
Despite the strange photos and videos coming out of Wuhan, China, there was no objective evidence of a once in a century disease approaching America’s shores, and the Diamond Princess outbreak made that clear.
Of course, it wasn’t the viral contagion that became the problem.
It was the hysteria contagion that brought out the worst qualities of much of the global ruling class, letting world leaders take off their proverbial masks in unison and reveal their true nature as power drunk madmen.
And even the more decent world leaders were swept up in the fear and mayhem, turning over the keys of government control to the supposed all-knowing Public Health Experts.
They quickly shuttered billions of lives and livelihoods, wreaking exponentially more havoc than a novel coronavirus ever could.
In the United States, 15 Days to Slow The Spread quickly became 30 Days To Slow The Spread. Somewhere along the way, the end date for “the measures” was removed from the equation entirely.
3 years later, there still isn’t an end date…
Anthony Fauci appeared on MSNBC Thursday morning and declared that Americans would need annual Covid boosters to compliment their Flu shots.
NEW - Fauci: Americans will likely need "a booster shot once a year."pic.twitter.com/Ec0zSWhV2b
— Disclose.tv (@disclosetv) March 16, 2023
So much of the Covid hysteria era was driven by pseudoscience and outright nonsense, and yet, very few if any world leaders took it upon themselves to restore sanity in their domains. Now, unsurprisingly, so many elected officials who were complicit in this multi-billion person human tragedy won’t dare to reflect upon it.
In a 1775 letter from John Adams to his wife, Abigail, the American Founding Father wrote:
“Liberty once lost is lost forever. When the People once surrender their share in the Legislature, and their Right of defending the Limitations upon the Government, and of resisting every Encroachment upon them, they can never regain it.”
Covid hysteria and the 3 year anniversary of 15 Days To Slow The Spread serves as the beginning period of a permanent scar resulting from government power grabs and federal overreach.
While life is back to normal in most of the country, the Overton window of acceptable policy has slid even further in the direction of push-button tyranny. Hopefully, much of the world has awakened to the reality that most of the people in charge aren’t actually doing what’s best for their respective populations.
Zoner
Veteran Member
I just listened to this because I'm familiar with Dr. Cottrell. I consider this a must listen interview.
rumble.com
Dr. Paul Cottrell reveals the next chimeric bioweapon likely to be deployed: SARS + HIV + H5N1
Dr. Paul Cottrell reveals the next chimeric bioweapon likely to be deployed: SARS + HIV + H5N1 For more updates, visit: http://www.brighteon.com/channel/hrreport NaturalNews videos would not be possib
rumble.com
Heliobas Disciple
TB Fanatic
I just listened to this because I'm familiar with Dr. Cottrell. I consider this a must listen interview.
Dr. Paul Cottrell reveals the next chimeric bioweapon likely to be deployed: SARS + HIV + H5N1
Dr. Paul Cottrell reveals the next chimeric bioweapon likely to be deployed: SARS + HIV + H5N1 For more updates, visit: http://www.brighteon.com/channel/hrreport NaturalNews videos would not be possib
I listened to it too. Good recommendation.
HD
Heliobas Disciple
TB Fanatic
COVID-19 death rates varied dramatically across US, major analysis finds
Death rates from COVID-19 varied dramatically across the United States, a major new analysis finds. COVID death rates in states like Arizona and New Mexico were roughly four times higher than in states like Hawaii, New Hampshire and Maine, researchers found. The highest COVID-19 death rates...
COVID-19 death rates varied dramatically across US, major analysis finds
DR. ALAA DIAB and DR. KEERTHANA KUMAR - ABC News
Wed, March 22, 2023, 8:34 PM EDT·3 min read
Death rates from COVID-19 varied dramatically across the United States, a major new analysis finds.
The report, published Monday in medical journal The Lancet, looked at the rate of deaths throughout the country between January 2020 and July 2022.
COVID death rates in states like Arizona and New Mexico were roughly four times higher than in states like Hawaii, New Hampshire and Maine, researchers found.
The highest COVID-19 death rates were seen in Arizona with 581 deaths per 100,000 and Washington D.C. with 526 deaths per 100,000.
By comparison, the lowest rates of death were seen in Hawaii with 147 deaths per 100,000, New Hampshire with 215 deaths per 100,000 and Maine with 218 deaths per 100,000.
The authors of the study noted that Arizona's high death rate from COVID-19 deaths may be due to "inequality, some poverty...ultimately [low] vaccination rates and behaviors didn't line up to have good outcomes."
States that did well, like Hawaii, New Hampshire and Washington state, are states -- in most cases -- "[that] have done a good job restricting travel, and in some cases have less poverty, less inequality, and relatively high vaccination rates."
Additionally, states with larger proportions of people who identified as Black or Hispanic witnessed higher death rates.
Lower rates of infection and death from COVID-19 were seen in states with higher education levels, lower poverty levels and higher rates of self-reported trust in the federal government and in the scientific community.
"Nearly every state, from the 26 worst performing states in the pandemic, fall into one of the three...[either] disproportionately high population of people identifying as Hispanic...higher than the national average identifying as black...or high levels of support for the 2020 republican presidential candidate," said lead author Tom Bollyky, a senior fellow for global health, economics, and development at the Council on Foreign Relations and professor of law at Georgetown University, in a video commentary.
The authors further discussed parts of the study highlighting racial, economic and social inequities in the U.S. that led to differences in rates of infection and death rates between states.
States with higher poverty rates of poverty had higher death rates. For every 2.6% increase in poverty rates above the national average within a state, there was a 23.3% increase in the cumulative death rate, reflecting a significant economic healthcare disparity.
"The COVID-19 pandemic clearly exacerbated fundamental social and economic inequities, but science-based interventions and policy changes provided clear impact on mortality rates at the state level," said Dr. John Brownstein, an epidemiologist and chief innovation officer at Boston Children's Hospital and an ABC News contributor.
Policies adopted by states during the pandemic, including mask mandates, social distancing and vaccine mandates, were associated with lower COVID-19 infection rates and higher vaccination rates were associated with lower death rates.
"We can invest in programs that protect the communities that we see disproportionately affected by the pandemic," said co-lead author Emma Castro, a researcher at the Institute of Health Metrics and Evaluation at the University of Washington, in the video commentary. "We can invest in programs such as paid family and sick leaves, expanded health insurance and expanded Medicaid."
She continued, "These sorts of programs will protect individuals in the lower income bracket, and hopefully help void some of the unnecessary loss that we experienced in the pandemic."
Heliobas Disciple
TB Fanatic
Senators press Moderna CEO on COVID-19 vaccine price hike
Moderna’s CEO on Wednesday defended a plan to more than quadruple the company’s COVID-19 vaccine price, but he also said the drugmaker will work to ensure patients continue paying nothing at drugstores or clinics. Stephane Bancel told the Senate Committee on Health, Education, Labor and...
Senators press Moderna CEO on COVID-19 vaccine price hike
TOM MURPHY - AP
Wed, March 22, 2023, 4:18 PM EDT
Moderna’s CEO on Wednesday defended a plan to more than quadruple the company’s COVID-19 vaccine price, but he also said the drugmaker will work to ensure patients continue paying nothing at drugstores or clinics.
Stephane Bancel told the Senate Committee on Health, Education, Labor and Pensions that the drugmaker will charge a list price of around $130 per dose for the vaccine in the U.S.
That price is expected to go into effect later this year. Until now, the federal government had been Moderna’s lone U.S. customer, buying doses in bulk to make sure that people weren’t charged anything.
The government paid around $15 per dose in 2020 and more than $26 last summer for Moderna’s bivalent booster, according to an analysis by the non-profit Kaiser Family Foundation.
More than 270 million doses of Moderna’s original COVID-19 vaccine and booster shots have been administered in the U.S., according to the U.S. Centers for Disease Control and Prevention. That makes it the second most popular coronavirus vaccine, trailing the shot made by Pfizer, which is also raising prices.
Sen. Bernie Sanders, I-Vt., noted that Moderna has made more than $20 billion in profits over the past two years, and the federal government contributed billions of dollars toward the vaccine’s development.
The hike will hit government payers like Medicaid and cost taxpayers, Sanders said as he pressed Bancel to reconsider the price.
The CEO said Moderna gave the government a discount with its initial prices. Now, the company must assume more costs and risk, he said.
He said, for instance, that the drugmaker will switch to single-dose vials from ones that held 10 doses.
He also that Moderna will have to make more doses than it anticipates using to ensure enough is available. The company will then have to eat the cost of unused doses, something the government has done.
“The volume we had during the pandemic gave us economies of scale we won’t have anymore,” he said.
Sanders later asked Bancel if Moderna was prepared to negotiate the price with Medicare, Medicaid and other agencies. Bancel replied that Moderna was “having discussions with all the different customers.”
While Moderna’s list price for its Spikevax vaccine will soar, company leaders have emphasized that people with insurance will continue to pay nothing out of pocket for the shots. Moderna also has a patient assistance program that will cover shots for people without coverage or who are underinsured.
Senators noted during Wednesday's hearing that these programs can involve complex paperwork and be difficult to use.
“We want that (patient assistance program) to be something that works for patients and is not just something that’s like, ’Oh yeah, we have it, but no one can use it,'” said Sen. Bill Cassidy, R-La., a doctor.
Bancel said Moderna will announce more details this fall on plans to help the uninsured, and the company was working to make the program as “easy as possible to access.”
Pfizer also has said it will charge $110 to $130 for a dose of its COVID-19 vaccine. It also cited the cost of switching to single-dose vials and commercial distribution in explaining the new prices. Pfizer used no government funding to develop its vaccine.
vector7
Dot Collector
Oops...
BOMBSHELL REPORT: Moderna CEO slips up, admits they paid NIH [National Institute of Health] $400 million in royalties just last year..
RT 1min
View: https://twitter.com/ChuckCallesto/status/1638644911414349825?s=20
BOMBSHELL REPORT: Moderna CEO slips up, admits they paid NIH [National Institute of Health] $400 million in royalties just last year..
RT 1min
View: https://twitter.com/ChuckCallesto/status/1638644911414349825?s=20
jward
passin' thru
hmm. Did y'all already mention the promising correlation tween metformin n long covid?
..iirc it's one o' the wonder anti-agin drugs. Betcha you can find some online, too
Nancy Lapid
@NancyLapid
3m
Did you miss @Reuters
Health Rounds today?
-14 days of metformin cuts long COVID risk
-Eye drops tied to serious infections
-Racial disparities seen in C-section care
See preview here: https://bit.ly/42xDvae
Sign up for free to get Tuesday’s edition: Newsletter
..iirc it's one o' the wonder anti-agin drugs. Betcha you can find some online, too
Nancy Lapid
@NancyLapid
3m
Did you miss @Reuters
Health Rounds today?
-14 days of metformin cuts long COVID risk
-Eye drops tied to serious infections
-Racial disparities seen in C-section care
See preview here: https://bit.ly/42xDvae
Sign up for free to get Tuesday’s edition: Newsletter
Zoner
Veteran Member
He tied it all together and showed the origins here in the US and how they are preparing a 4th and 5th bio-weapon.
Zoner
Veteran Member
Heliobas Disciple
TB Fanatic
Heliobas Disciple
TB Fanatic
COVID left some with damaged immune response, study finds
Scientists found a "major reduction" in a part of T cell responses in people who were infected before being vaccinated.
COVID left some with damaged immune response, study finds
Alexander Tin - CBS News
Thu, March 23, 2023, 11:57 AM EDT
A key piece of the body's immune response to COVID-19 looks to have been damaged in people who caught the disease before they were vaccinated, a study published this month found, resulting in a "major reduction" to part of the defense the body typically musters to fight off the virus.
"You have damage that, even in recovery from the infection, you haven't really recovered your ability to make those CD8+ cells. So something happened in the course of infection to prevent that, to damage your response," said Stanford Professor Mark Davis, head of the university's Institute for Immunity, Transplantation and Infection. Davis is lead author of the paper, which was published this month in the journal Immunity.
CD4+ T cells, often dubbed "helper T cells" for their role in marshaling other parts of the immune response, appeared to be undamaged.
But Davis and his team found the response of CD8+ T cells, known as "killer T cells" for their role in destroying infected cells, was substantially worse in people who had survived an infection, with both the quantity and quality of the cells diminished. A disparity remained even after those people got vaccinated with the Pfizer-BioNTech vaccine.
"Looking at the broader swath of data, we came up with a seven-fold average reduction. But it was much larger in several of the cases. So that's a big deal," Davis said.
While researchers often look to antibodies first to measure the body's initial protection against an infection, an array of T cells also make up an essential part of the body's defenses. Davis and his team engineered a unique approach to measuring this response, leveraging a reagent they developed to essentially label a detailed picture of the T cells.
"Technology-wise, looking at the T cell response and quantitatively measuring it is harder than antibody detection. That's why there's a need to improve that technology and also relate it to vaccine development," said Chao Jiang, a program officer for the National Institutes of Health. Jiang oversaw the research, which was funded by the agency.
Davis thinks the dropoff could result in the immune system taking longer to root out infected cells. Compared to others without the damage, it could also potentially make it harder to gain the full benefit from the vaccine they got and fend off new variants.
"I think it would be probably too much of a speculation to say that this could impair responses to other viruses. But SARS-CoV-2 variants have not gone away. They're out there," he said.
The study's authors likened the dysfunction to that seen in their previous work with viruses like hepatitis C or HIV, lingering even after infections were quelled.
"So there are probably, after these years of study, we know that SARS-CoV-2 actually did alter our host immune response. And this CD8 T cell dysfunction may be just one aspect of it," said Jiang.
Not every infectious disease has been linked to this kind of lasting dysfunction, Jiang said. But she cautioned that this does not mean SARS-CoV-2 inflicts the same kind of devastation that HIV can wreak on the immune system.
"This dysfunction may have some long-term immune consequences. It may be possibly related to long COVID, but we don't know. And there is a lot of work ongoing, and I think we will understand more about the mechanism," said Jiang.
It will also be important to study how this damage squares with other parts of the body's complex immune response. Jiang noted research elsewhere has turned up signs of superior antibody protection from people who were both infected and vaccinated.
"That's why, in my mind, it's very important to follow up a study like this, especially when our clinical cohort is getting more years down the road, so that we could be able to correlate that with some more clinical symptoms," Jiang said.
One limitation of this paper from Davis is that they relied on "peripheral" T cells in the blood. Gathering samples from elsewhere in the body — for example the lungs, where the immune response might look strongest — cannot be done with living humans.
However, Davis pointed out their measurements turned up other kinds of T cells for the virus in the blood at levels that looked fine.
"This question has been raised like a million times. And basically, what I would say is that everything ends up in the circulation eventually," said Davis.
Some of the phenomenon they discovered may also be unique to the population scientists tested: people who got an mRNA vaccine for COVID-19 after they were infected.
Davis suggested it was possible people may see different results more years after their initial infection, especially in people who mix-and-matched with other vaccines for their booster.
"Maybe, as we go further along to look at some of those damaged CD8 responses, can we bring them back? Or do people recover after?" he said.
Heliobas Disciple
TB Fanatic
Court blocks COVID-19 vaccine mandate for US gov't workers
President Joe Biden’s order that federal employees get vaccinated against COVID-19 was blocked Thursday by a federal appeals court. The 5th U.S. Circuit Court of Appeals in New Orleans rejected arguments that Biden, as the nation’s chief executive, has the same authority as the CEO of a private...
Court blocks COVID-19 vaccine mandate for US gov't workers
KEVIN MCGILL
Thu, March 23, 2023, 7:49 PM EDT
NEW ORLEANS (AP) — President Joe Biden’s order that federal employees get vaccinated against COVID-19 was blocked Thursday by a federal appeals court.
The 5th U.S. Circuit Court of Appeals in New Orleans rejected arguments that Biden, as the nation’s chief executive, has the same authority as the CEO of a private corporation to require that employees be vaccinated.
The ruling from the full appeals court, 16 full-time judges at the time the case was argued, reversed an earlier ruling by a three-judge 5th Circuit panel that had upheld the vaccination requirement. Judge Andrew Oldham, nominated to the court by then-President Donald Trump, wrote the opinion for a 10-member majority.
The ruling maintains the status quo for federal employee vaccines. It upholds a preliminary injunction blocking the mandate issued by a federal judge in January 2022. At that point, the administration said nearly 98% of covered employees had been vaccinated.
And, Oldham noted, with the preliminary injunction arguments done, the case will return to that court for further arguments, when “both sides will have to grapple with the White House’s announcement that the COVID emergency will finally end on May 11, 2023.”
Opponents of the policy said it was an encroachment on federal workers’ lives that neither the Constitution nor federal statutes authorize.
Biden issued an executive order in September 2021 requiring vaccinations for all executive branch agency employees, with exceptions for medical and religious reasons. The requirement kicked in the following November. U.S. District Judge Jeffrey Brown, who was appointed to the District Court for the Southern District of Texas by Trump, issued a nationwide injunction against the requirement the following January.
The case then went to the 5th Circuit.
One panel of three 5th Circuit judges refused to immediately block the law.
But a different panel, after hearing arguments, upheld Biden’s position. Judges Carl Stewart and James Dennis, both nominated to the court by President Bill Clinton, were in the majority. Judge Rhesa Barksdale, nominated by President George H.W. Bush, dissented, saying the relief the challengers sought does not fall under the Civil Service Reform Act cited by the administration.
The broader court majority agreed, saying federal law does not preclude court jurisdiction over cases involving "private, irreversible medical decisions made in consultation with private medical professionals outside the federal workplace."
A majority of the full court voted to vacate that ruling and reconsider the case. The 16 active judges heard the case on Sept. 13, joined by Barksdale, who is now a senior judge with lighter duties than the full-time members of the court.
Judge Stephen Higginson, a nominee of former President Barack Obama, wrote the main dissenting opinion. "For the wrong reasons, our court correctly concludes that we do have jurisdiction," Higginson wrote. "But contrary to a dozen federal courts — and having left a government motion to stay the district court’s injunction pending for more than a year — our court still refuses to say why the President does not have the power to regulate workplace safety for his employees."
___
The date of President Joe Biden's executive order has been corrected to September 2021, not last September.
Heliobas Disciple
TB Fanatic
Nasal Vaccines: Stopping the COVID-19 Virus Before It Reaches the Lungs
The Pfizer-BioNTech and Moderna mRNA vaccines have played a large role in preventing deaths and severe infections from COVID-19. But researchers are still in the process of developing alternative approaches to vaccines to improve their effectiveness, including how they’re administered. Immunologist
scitechdaily.com
Nasal Vaccines: Stopping the COVID-19 Virus Before It Reaches the Lungs
By Michael W. Russell, University at Buffalo
March 23, 2023
The Pfizer-BioNTech and Moderna mRNA vaccines have played a large role in preventing deaths and severe infections from COVID-19. But researchers are still in the process of developing alternative approaches to vaccines to improve their effectiveness, including how they’re administered. Immunologist and microbiologist Michael W. Russell of the University at Buffalo explains how nasal vaccines work, and where they are in the development pipeline.
How does the immune system fight pathogens?
The immune system has two distinct components: mucosal and circulatory.
The mucosal immune system provides protection at the mucosal surfaces of the body. These include the mouth, eyes, middle ear, the mammary and other glands, and the gastrointestinal, respiratory, and urogenital tracts. Antibodies and a variety of other anti-microbial proteins in the sticky secretions that cover these surfaces, as well as immune cells located in the lining of these surfaces, directly attack invading pathogens.
The circulatory part of the immune system generates antibodies and immune cells that are delivered through the bloodstream to the internal tissues and organs. These circulating antibodies do not usually reach the mucosal surfaces in large enough amounts to be effective. Thus mucosal and circulatory compartments of the immune system are largely separate and independent.
What are the key players in mucosal immunity?
The immune components people may be most familiar with are proteins known as antibodies, or immunoglobulins. The immune system generates antibodies in response to invading agents that the body identifies as “non-self,” such as viruses and bacteria.
Antibodies bind to specific antigens: the part or product of a pathogen that induces an immune response. Binding to antigens allows antibodies to either inactivate them, as they do with toxins and viruses, or kill bacteria with the help of additional immune proteins or cells.
The mucosal immune system generates a specialized form of antibody called secretory IgA, or SIgA. Because SIgA is located in mucosal secretions, such as saliva, tears, nasal and intestinal secretions, and breast milk, it is resistant to digestive enzymes that readily destroy other forms of antibodies. It is also superior to most other immunoglobulins at neutralizing viruses and toxins, and at preventing bacteria from attaching to and invading the cells lining the surfaces of organs.
There are also many other key players in the mucosal immune system, including different types of anti-microbial proteins that kill pathogens, as well as immune cells that generate antibody responses.
How does the COVID-19 virus enter the body?
Almost all infectious diseases in people and other animals are acquired through mucosal surfaces, such as by eating or drinking, breathing or sexual contact. Major exceptions include infections from wounds, or pathogens delivered by insect or tick bites.
The virus that causes COVID-19, SARS-CoV-2, enters the body via droplets or aerosols that get into your nose, mouth, or eyes. It can cause severe disease if it descends deep into the lungs and causes an overactive, inflammatory immune response.
This means that the virus’s first contact with the immune system is probably through the surfaces of the nose, mouth, and throat. This is supported by the presence of SIgA antibodies against SARS-CoV-2 in the secretions of infected people, including their saliva, nasal fluid, and tears. These locations, especially the tonsils, have specialized areas that specifically trigger mucosal immune responses.
Some research suggests that if these SIgA antibody responses form as a result of vaccination or prior infection, or occur quickly enough in response to a new infection, they could prevent serious disease by confining the virus to the upper respiratory tract until it is eliminated.
How do nasal vaccines work?
Vaccines can be given through mucosal routes via the mouth or nose. This induces an immune response through areas that stimulate the mucosal immune system, leading mucosal secretions to produce SIgA antibodies.
There are several existing mucosal vaccines, most of them taken by mouth. Currently, only one, the flu vaccine, is delivered nasally.
In the case of nasal vaccines, the viral antigens intended to stimulate the immune system would be taken up by immune cells within the lining of the nose or tonsils. While the exact mechanisms by which nasal vaccines work in people have not been thoroughly studied, researchers believe they work analogously to oral mucosal vaccines. Antigens in the vaccine induce B cells in mucosal sites to mature into plasma cells that secrete a form of IgA. That IgA is then transported into mucosal secretions throughout the body, where it becomes SIgA.
If the SIgA antibodies in the nose, mouth or throat target SARS-CoV-2, they could neutralize the virus before it can drop down into the lungs and establish an infection.
What advantage do mucosal vaccines have against COVID-19?
I believe that arguably the best way to protect an individual against COVID-19 is to block the virus at its point of entry, or at least to confine it to the upper respiratory tract, where it might inflict relatively little damage.
Breaking chains of viral transmission is crucial to controlling epidemics. Researchers know that COVID-19 spreads during normal breathing and speech, and is exacerbated by sneezing, coughing, shouting, singing and other forms of exertion. Because these emissions mostly originate from saliva and nasal secretions, where the predominant form of antibody present is SIgA, it stands to reason that secretions with a sufficiently high level of SIgA antibodies against the virus could neutralize and thereby diminish its transmissibility.
Existing vaccines, however, do not induce SIgA antibody responses. Injected vaccines primarily induce circulating IgG antibodies, which are effective in preventing serious disease in the lungs. Nasal vaccines specifically induce SIgA antibodies in nasal and salivary secretions, where the virus is initially acquired, and can more effectively prevent transmission.
Nasal vaccines may be a useful supplement to injected vaccines in hot spots of infection. Since they don’t require needles, they might also help overcome vaccine hesitancy due to fear of injections.
How close are researchers to creating a nasal COVID-19 vaccine?
There have been over 100 oral or nasal COVID-19 vaccines in development around the world.
Most of these have been or are currently being tested in animal models. Many have reported successfully inducing protective antibodies in the blood and secretions, and have prevented infection in these animals. However, few have been successfully tested in people. Many have been abandoned without fully reporting study details.
According to the World Health Organization, 14 nasal COVID-19 vaccines are in clinical trials as of late 2022. Reports from China and India indicate that nasal or inhaled vaccines have been approved in these countries. But little information is publicly available about the results of the studies supporting approval of these vaccines.
Written by Michael W. Russell, Professor Emeritus of Microbiology and Immunology, University at Buffalo. This article was first published in The Conversation.
Heliobas Disciple
TB Fanatic
How They Convinced Trump to Lock Down ⋆ Brownstone Institute
This scenario cannot be proven because the entire event remains cloaked in secrecy. Not even Senator Rand Paul can get the information.
brownstone.org
How They Convinced Trump to Lock Down
By Jeffrey A. Tucker
March 23, 2023
An enduring mystery for three years is how Donald Trump came to be the president who shut down American society for what turned out to be a manageable respiratory virus, setting off an unspeakable crisis with waves of destructive fallout that continue to this day.
Let’s review the timeline and offer some well-founded speculations about what happened.
On March 9, 2020, Trump was still of the opinion that the virus could be handled by normal means.
So last year 37,000 Americans died from the common Flu. It averages between 27,000 and 70,000 per year. Nothing is shut down, life & the economy go on. At this moment there are 546 confirmed cases of CoronaVirus, with 22 deaths. Think about that!
— Donald J. Trump (@realDonaldTrump) March 9, 2020
Two days later, he changed his tune. He was ready to use the full power of the federal government in a war on the virus.
I am fully prepared to use the full power of the Federal Government to deal with our current challenge of the CoronaVirus!
— Donald J. Trump (@realDonaldTrump) March 11, 2020
What changed? Deborah Birx reports in her book that Trump had a friend die in a New York hospital and this is what shifted his opinion. Jared Kushner reports that he simply listened to reason. Mike Pence says he was persuaded that his staff would respect him more. No question (and based on all existing reports) that he found himself surrounded by “trusted advisors” amounting to about 5 or so people (including Mike Pence and Pfizer board member Scott Gottlieb)
It was only a week later when Trump issued the edict to close all “indoor and outdoor venues where people congregate,” initiating the biggest regime change in US history that flew in the face of all rights and liberties Americans had previously taken for granted. It was the ultimate in political triangulation: as John F. Kennedy cut taxes, Nixon opened China, and Clinton reformed welfare, Trump shut down the economy he promised to revive. This action confounded critics on all sides.
A month later, Trump said his decision to have “turned off” the economy saved millions of lives, later even claiming to have saved billions. He has yet to admit error.
….My Administration and I built the greatest economy in history, of any country, turned it off, saved millions of lives, and now am building an even greater economy than it was before. Jobs are flowing, NASDAQ is already at a record high, the rest to follow. Sit back & watch!
— Donald J. Trump (@realDonaldTrump) August 18, 2020
Even as late as June 23rd of that year, Trump was demanding credit for having followed all of Fauci’s recommendations. Why do they love him and hate me, he wanted to know.
We did a great job on CoronaVirus, including the very early ban on China, Ventilator production, and Testing, which is by far the most, and best, in the World. We saved millions of U.S. lives.! Yet the Fake News refuses to acknowledge this in a positive way. But they do give….
— Donald J. Trump (@realDonaldTrump) June 23, 2020
Something about this story has never really added up. How could one person have been so persuaded by a handful of others such as Fauci, Birx, Pence, and Kushner and his friends? He surely had other sources of information – some other scenario or intelligence – that fed into his disastrous decision.
In one version of events, his advisors simply pointed to the supposed success of Xi Jinping in enacting lockdowns in Wuhan, which the World Health Organization claimed had stopped infections and brought the virus under control. Perhaps his advisors flattered Trump with the observation that he is at least as great as the president of China so he should be bold and enact the same policies here.
One problem with this scenario is timing. The Oval Office meetings that preceded his March 16, 2020, edict took place the weekend of the 14th and 15th, Friday and Saturday. It was already clear by the 11th that Trump was ready for lockdowns. This was the same day as Fauci’s deliberately misleading testimony to the House Oversight Committee in which he rattled the room with predictions of Hollywood-style carnage.
On the 12th, Trump shut all travel from Europe, the UK, and Australia, causing huge human pile-ups at international airports. On the 13th, the Department of Health and Human Services issued a classified document that transferred control of pandemic policy from the CDC to the National Security Council and eventually the Department of Homeland Security. By the time that Trump met with Fauci and Birx in that legendary weekend, the country was already under quasi-martial law.
Isolating the date in the trajectory here, it is apparent that whatever happened to change Trump occurred on March 10, 2020, the day after his Tweet saying there should be no shutdowns and two days before Fauci’s testimony.
That something very likely revolves around the most substantial discovery we’ve made in three years of investigations. It was Debbie Lerman who first cracked the code: Covid policy was forged not by the public-health bureaucracies but by the national-security sector of the administrative state. She has further explained that this occurred because of two critical features of the response: 1) the belief that this virus came from a lab leak, and 2) the vaccine was the biosecurity countermeasure pushed by the same people as the fix.
Knowing this, we gain greater insight into 1) why Trump changed his mind, 2) why he has never explained this momentous decision and otherwise completely avoids the topic, and 3) why it has been so unbearably difficult to find out any information about these mysterious few days other than the pablum served up in books designed to earn royalties for authors like Birx, Pence, and Kushner.
Based on a number of second-hand reports, all available clues we have assembled, and the context of the times, the following scenario seems most likely. On March 10, and in response to Trump’s dismissive tweet the day before, some trusted sources within and around the National Security Council (Matthew Pottinger and Michael Callahan, for example), and probably involving some from military command and others, came to Trump to let him know a highly classified secret.
Imagine a scene from Get Smart with the Cone of Silence, for example. These are the events in the life of statecraft that infuse powerful people with a sense of their personal awesomeness. The fate of all of society rests on their shoulders and the decisions they make at this point. Of course they are sworn to intense secrecy following the great reveal.
The revelation was that the virus was not a textbook virus but something far more threatening and terrible. It came from a research lab in Wuhan. It might in fact be a bioweapon. This is why Xi had to do extreme things to protect his people. The US should do the same, they said, and there is a fix available too and it is being carefully guarded by the military.
It seems that the virus had already been mapped in order to make a vaccine to protect the population. Thanks to 20 years of research on mRNA platforms, they told him, this vaccine can be rolled out in months, not years. That means that Trump can lock down and distribute vaccines to save everyone from the China virus, all in time for the election. Doing this would not only assure his reelection but guarantee that he would go down in history as one of the greatest US presidents of all time.
This meeting might only have lasted an hour or two – and might have included a parade of people with the highest-level security clearances – but it was enough to convince Trump. After all, he had battled China for two previous years, imposing tariffs and making all sorts of threats. It was easy to believe at that point that China might have initiated biological warfare as retaliation. That’s why he made the decision to use all the power of the presidency to push a lockdown under emergency rule.
To be sure, the Constitution does not allow him to override the discretion of the states but with the weight of the office complete with enough funding and persuasion, he could make it happen. And thus did he make the fateful decision that not only wrecked his presidency but the country too, imposing harms that will last a generation.
It only took a few weeks for Trump to become suspicious about what happened. For weeks and months, he toggled between believing that he was tricked and believing that he did the right thing. He had already approved another 30 days of lockdowns and even inveighed against Georgia and later Florida for opening. He went so far as to claim that no state could open without his approval.
For the purpose of creating conflict and confusion, some in the Fake News Media are saying that it is the Governors decision to open up the states, not that of the President of the United States & the Federal Government. Let it be fully understood that this is incorrect….
— Donald J. Trump (@realDonaldTrump) April 13, 2020
He did not fully change his mind until August, when Scott Atlas revealed the whole con to him.There is another fascinating feature to this entirely plausible scenario. Even as Trump’s advisors were telling him that this could be a bioweapon leaked from the lab in China, we had Anthony Fauci and his cronies going to great lengths to deny it was a lab leak (even if they believed that it was). This created an interesting situation. The NIH and those surrounding Fauci were publicly insisting that the virus was of zoonotic origin, even as Trump’s circle was telling the president that it should be regarded as a bioweapon.
Fauci belonged to both camps, which suggests that Trump very likely knew of Fauci’s deception all along: the “noble lie” to protect the public from knowing the truth. Trump had to be fine with that.
Gradually following the lockdown edicts and the takeover by the Department of Homeland Security, in cooperation with a very hostile CDC, Trump lost power and influence over his own government, which is why his later Tweets urging a reopening fell on deaf ears. To top it off, the vaccine failed to arrive in time for the election. This is because Fauci himself delayed the rollout until after the election, claiming that the trials were not racially diverse enough. Thus Trump’s gambit completely failed, despite all the promises of those around him that it was a guaranteed way to win reelection.
To be sure, this scenario cannot be proven because the entire event – certainly the most dramatic political move in at least a generation and one with unspeakable costs for the country – remains cloaked in secrecy. Not even Senator Rand Paul can get the information he needs because it remains classified. If anyone thinks the Biden approval of releasing documents will show what we need, that person is naive. Still, the above scenario fits all available facts and it is confirmed by second-hand reports from inside the White House.
It’s enough for a great movie or a play of Shakespearean levels of tragedy. And to this day, none of the main players are speaking openly about it.
Heliobas Disciple
TB Fanatic
Excess Mortality News Supports the "Geert Variant" Theory
In Good News, Excess Mortality Went Down
igorchudov.substack.com
Excess Mortality News Supports the "Geert Variant" Theory
In Good News, Excess Mortality Went Down
Igor Chudov
Mar 23
I wrote many posts on excess mortality. (Here’s a brief guide to them.)
It is exciting to see that a preprint article found the same association between death rates and vaccinations, where paradoxically, higher vaccination coverage led to higher mortality.
For those who like videos, here’s John Campbell discussing this preprint:
14 min 52 sec
Vaccines are supposed to save lives! Instead, we see that the more vaccines, the greater the mortality increases.
I found that same relationship in several articles, such as this one:
My first finding of this nature was published on Aug 30, 2022, and was shared quite a bit on social networks:
I am glad Jarle Aarstad and Olav Kvitastein found a similar relationship in European data.Sadly, this pattern of vaccines associated with higher mortality held strong over time. If you remember, December of 2022 was a month of illness and death across Europe.
Strong Association Between Vaccines and Deaths in December 2022
I decided to compare excess mortality for weeks 48-52 (5 weeks) of 2022, as the data for this period is finally available for many countries. The vaccination rates (as of Mar 2022) come from Our World in Data, and the excess mortality was recorded based on information from the short-term mortality database.Here’s the data for weeks 48-52 of 2022:
I analyzed this dataset with a linear regression calculator:
You can see that the relationship has great statistical significance and no major outliers. Is there a causal relationship? I have written much about it, and Martin Neil and Norman Fenton analyzed it also.
The preprint above comes to the same conclusion:
When controlling for alternative explanations, the association remained robust, and we discuss the result emphasizing causality as well as potential ecological fallacy.
The authors thoroughly analyze the data and rule out Simpson’s Paradox and other vaccine advocates' contentions. Those curious may find a lot of interesting arguments against typical rebuttals of causality that we hear about. Take a look at pages 6 and 7 of the preprint.The Good Mortality News - for my Theory and Europe
In the Covid-vaccine skeptic world, many opponents of Covid vaccines suggest that vaccines cause deaths via various direct mechanisms. (“spike protein slowly kills heart” or some such)They may partly be right; however, such a straightforward explanation does not explain great month-to-month variations in death rates.
I claimed that excess mortality associated with Covid vaccines is mediated via transmissible illnesses such as Covid-19 or the flu, causing more deaths in Covid-vaccinated or boosted people.
Fortunately, mortality news from February and March suggests that the above statement is correct. Why? The mortality went DOWN by a lot, and in Germany, for example, excess mortality recently became negative. That suggests that temporary factors such as transmissible illnesses were involved!
You can download the latest German mortality data from this Excel spreadsheet.
This is, obviously, great news for Germany. The UK is also experiencing a welcome reduction in excess deaths after experiencing the worst mortality in years this January:
You can see that there is more to the story than “vaccine spike protein slowly killing people.” There is something that causes excess death rates to jump up and down! Thus, I believe mortality is mediated by transmissible illnesses- Covid or the flu - but affects vaccinated people disproportionally.
I hope that this reduction in excess mortality will prove permanent. I am afraid, however, that it is temporary, and mortality will jump up again when the next wave of “Covid variants” or other mystery illnesses sickens people.
The future is hard to predict, and I will be most delighted if excess mortality goes away permanently.
Let us know what you think!