CORONA Main Coronavirus thread

Countrymouse

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Trump's former CDC director makes bombshell COVID claim that 'there is a real possibility' virus was born in North Carolina
By STEPHEN M. LEPORE FOR DAILYMAIL.COM
Published: 23:10 EST, 17 November 2024 | Updated: 23:32 EST, 17 November 2024

A former director of the CDC under Donald Trump says he believes COVID-19 may have been born in a North Carolina laboratory as part of a secret biodefense program.

Robert Redfield has previously been a proponent of the 'lab leak' theory which posits the disease came from the Wuhan Institute of Virology in China.

Now Redfield - a frequent critic of Dr. Anthony Fauci - says that the disease may have origins in the Tar Heel State.

Appearing on the Third Opinion podcast, Redfield flat out stated that COVID-19 was 'intentionally engineered as a part of a biodefense program.'

He now argues that China did not necessarily create the virus and did the best that they could once 'they realized they had a problem.

However, he calls the United States' role in the development of the virus 'substantial.'

He claims that the American government holds responsibility for funding research into the NIH, USAID and the Department of Defense.

He then calls out researcher Dr. Ralph Baric from the University of North Carolina, whom he calls 'the scientific mastermind' behind all of this.

'I think he probably helped create some of the original viral lines, but I can’t prove that. But he was very involved,' he said.

When pressed on whether the virus was 'actually developed here' and that the Chinese may have been wrongfully accused of developing the virus, Redfield doubles down.

'Well, I don’t know if they were framed, but I think there is a real possibility that the virus’s birthplace was Chapel Hill,' Redfield said, naming the hometown of the University of North Carolina.

DailyMail.com has reached out to Dr. Baric for comment.

The virus is believed to have originated in bats, but debate is currently raging over whether it leaked from the Wuhan lab - and whether it was modified by Chinese scientists to become more contagious beforehand.

Redfield, who was CDC director under the Trump administration, has in the past said Fauci was 'holding on tightly' to the theory that the virus evolved naturally, before likening the White House COVID tsar to a 'dog with a bone.'

And in 2021, he slammed the 'highly compromised' World Health Organization for not cracking down on China at the start of the COVID-19 pandemic, and for letting its communist government dictate the terms of the WHO probe into the origins of COVID.

Donald Trump and his supporters were widely derided for sharing the same theory when he was president.

Redfield, who doesn't believe the virus was intentionally leaked by China, said COVID-19's ability to spread rapidly from human-to-human was unlike other coronaviruses such as SARS.

Redfield said he was 'disappointed' there was a lack of openness within the scientific community early on to investigate both hypotheses.

Some scientists, the media and academics long heaped scorn on the lab leak hypothesis, insisting that it was a fringe conspiracy theory and even racist after Donald Trump embraced the idea.

New evidence, including reports of three workers at the Wuhan lab who fell seriously ill with COVID-like symptoms in November 2019, has forced a sober reassessment among doubters.

Redfield went on to say that it was a 'critical error' to treat COVID-19 the same as SARS in January and February last year.

'By calling it SARS-like, we mounted a public health response that was mirrored off SARS. The problem is, COVID is nothing like SARS,' Redfield said, adding that response was 'flawed'.

Redfield acknowledged that he should have pushed harder for the CDC to be allowed into the Wuhan lab when the virus first emerged and said the World Health Organization was compromised by China.

'I think they were highly compromised. Clearly they were incapable of compelling China to adhere to the treaty agreements they have on global health,' Redfield said.
What was the name of that lady Chinese doctor and her husband Huber either sent home or deported early on I think in 2019 who had been working on the Covid virus at that college in North Carolina?
 

Countrymouse

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Long COVID and Exercise Intolerance Unveiled by Yale Researchers
Nikhil Prasad Fact checked by:Thailand Medical News Team
Nov 19, 2024

Exercise intolerance is a troubling problem for many living with long COVID, a condition officially known as post-acute sequelae of SARS-CoV-2 infection (PASC). Researchers from Yale School of Medicine recently published a groundbreaking study shedding light on why even mild physical activity can feel like an uphill battle for long COVID patients. The findings provide insights into the physiological and metabolic impairments causing these symptoms, paving the way for better treatments.

This Medical News report explains the research in simple terms, highlighting the study's methodology and findings to make the science accessible to everyone. It offers a clear perspective on how long COVID affects exercise tolerance and what future research might mean for patients.

Understanding the Study
The study involved 47 long COVID patients who underwent invasive cardiopulmonary exercise testing (iCPET). This advanced testing measures oxygen use and metabolic changes in the body during exercise. By comparing data from mild versus severe initial COVID-19 infections, the team uncovered key insights into the body’s response to physical exertion.

Among the study’s participants, eight had been hospitalized for severe COVID-19, while the remaining 39 experienced milder cases. Despite differences in initial illness severity, all participants reported significant and unexplained exercise limitations.


Key Findings: What’s Happening in the Body?
-Reduced Oxygen Use in Muscles

Long COVID patients exhibited reduced peak oxygen extraction (EO2) during exercise, suggesting their muscles struggle to use oxygen effectively. This problem was more pronounced in those who had severe initial COVID infections. However, cardiac output (the amount of blood the heart pumps) was within normal ranges, indicating that the issue lies with the muscles rather than the heart.

-Switch to Anaerobic Energy
When oxygen-dependent energy production falls short, the body relies on anaerobic metabolism, a less efficient backup system. The researchers observed that long COVID patients began using this backup system at lower exercise intensities, even during everyday activities like climbing stairs.

-Metabolic Changes and Potential Biomarkers
The team performed detailed metabolomic analysis, examining blood samples for signs of how the body’s metabolism shifts during exercise. They found increased levels of succinate and inosine, metabolites linked to energy production. Elevated succinate, in particular, correlated with worse exercise tolerance, suggesting it could serve as a biomarker to identify long COVID severity.

-Impaired Energy Production
Long COVID patients showed reduced capacity to produce energy through both aerobic and anaerobic pathways. This dual impairment leaves patients with limited ability to sustain physical activity, leading to quicker fatigue.


What These Findings Mean
The study highlights that long COVID’s impact on exercise tolerance stems from a mix of impaired oxygen use and altered metabolic pathways. This combination results in an early reliance on anaerobic energy production, which is less efficient and contributes to fatigue. The researchers suggest that targeting these metabolic dysfunctions could offer new ways to treat long COVID symptoms.

For example, therapies aimed at improving mitochondrial function (the part of the cell responsible for energy production) or enhancing the purine nucleotide cycle (which supports energy generation during high-intensity exercise) might help patients recover their ability to exercise comfortably.


Moving Forward: Hope for Treatment
While this study provides significant insights, it’s just the beginning. The researchers plan to expand their work to include larger groups and healthy control participants to refine their findings. They also hope to explore new treatments based on the metabolic impairments identified in their study.

For long COVID patients, these findings offer hope. Identifying biomarkers like succinate and understanding the role of purine metabolism opens doors to targeted therapies that could restore energy levels and improve quality of life.


Conclusion: A Step Toward Recovery
Exercise intolerance is a major barrier for many people living with long COVID, but understanding its root causes marks a critical step toward finding solutions. This Yale-led study offers valuable insights into the physiological and metabolic changes driving these symptoms, emphasizing the importance of oxygen and energy production in recovery. By uncovering potential biomarkers and therapeutic targets, the research team has laid the groundwork for future innovations in long COVID treatment.

The study findings were published in the peer-reviewed journal: Pulmonary Circulation.

Which goes to show, once again, that both the virus, and its supposed cure – the shot – attack the blood itself.
 

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Research Points to COVID’s ‘Long Tail’ on School Graduation Rates
Linda Jacobson - The74
Tue, November 19, 2024 at 11:30 AM UTC

The majority of states, 26, saw declines in high school graduation rates following the pandemic, new research shows.

In 2020, for example, 10 states had graduation rates of 90% or higher, but only five did in 2022, according to Tuesday’s analysis from the Grad Partnership, a network of nonprofits working to improve student outcomes.

But the report suggests that the full impact of COVID school closures on graduation rates has yet to be realized. This year’s seniors, for example, were seventh graders when the pandemic hit in March, 2020 and likely spent much of eighth grade learning remotely or in a cycle of on-again, off-again in-person learning.

That’s why the pandemic’s effects on graduation rates and college enrollment could have a “long tail,” the report says.

“Graduating from high school is a long process,” said Robert Balfanz, director of the Everyone Graduates Center at Johns Hopkins University, which supports the Grad Partnership. “It’s the younger kids that may be more impacted.”

The pandemic disturbed a trend of rising graduation rates that began in 2011, driven largely by gains among minorities. But an overall increase following the pandemic was due to state and local efforts to minimize the impact of the COVID emergency rather than actual educational improvement, Balfanz said.

State and local decisions to relax grading policies, accept late work and drop exit exam requirements gave the appearance that more students were meeting expectations. That’s why additional information, like whether ninth graders have earned enough credits to advance to 10th grade, chronic absenteeism data and the rates of students taking advanced courses have become increasingly valuable indicators of whether students are on track.

Meanwhile, states and districts varied widely on how deeply COVID affected families, how long schools were closed and whether they were equipped to respond to the crisis.

“We know some schools took extraordinary efforts to make sure their seniors graduated,” Balfanz said. “Others may not have had that capacity.”

Some students lacked stable Wi-Fi at home or had to go to work when parents were sick, while other families had the resources to hire tutors and form pods or attended schools that reopened in the fall of 2020.

Ohio saw the largest increase in rates between 2019 and 2022 — from 82% to 86.2%, while New Jersey saw the greatest decline, from 90.6% to 85.2%. But actions in two large states — California and New York — actually pushed the national rate to an all-time high, from 85.8% in 2019 to 86.6%.

Both states waived graduation requirements, like required courses and exams, for students. Meanwhile, New Jersey’s stricter definition of on-time graduation for students with disabilities likely contributed to the drop, the report said.

At the district level, rates varied widely. Of the nearly 7,000 districts included in the analysis, about a third saw higher graduation rates in 2022 than in 2019, while roughly the same percentage saw a decline. Rates were stable in about 38% of districts.

But the data, Balfanz said, suggests that districts should start as soon as students enter high school to make sure they’re making progress toward graduation.

As part of their state accountability systems, six states currently monitor whether ninth graders are having a successful first year in high school. Data from five of those states — Connecticut, Delaware, Illinois, Oregon and Washington — shows significantly fewer students were on track in 2021-22 than in 2018-19.

“These students may bear more of the brunt of the pandemic’s impact on high school graduation rates than students who experienced the pandemic as 10th and 11th graders,” the report said.

Chronic absenteeism, which remains above 25% in some states, is also tougher to get under control at the high school level than in earlier grades and is “the wild card for a prolonged period of pandemic impacts on educational attainment,” the report said.


‘Hybrid and weird’

Adam Larsen, assistant superintendent of the Oregon Community School District in Illinois, west of Chicago, remembers how much students who were seventh graders when schools shut down struggled in their freshman year.

“That eighth grade year was hybrid and weird. We had social distancing and no vaccine,” he said. “Socially, they just didn’t mature. Freshman year tried to be normal, and they weren’t ready for normal.”

The Oregon district also offers an afterschool mentoring program, called Hawks Take Flight, designed to prevent students from falling so far behind, because of absenteeism or missing work, that they can’t graduate on time.

At the weekly sessions, students talk about what’s getting in their way. If they meet their goals for the week, they earn prizes.

“Our graduation rate has been high and remains high because of the amount of support that we put in there,” Larsen said. “We have made it impossibly hard for students to fail unless they’ve chosen to fail.”
‘Make the diploma meaningful’

The way districts used their $190 billion in pandemic relief money also determined whether students received enough help to keep up with their work.

Diman Regional Vocational Technical High School, in Fall River, Massachusetts, near the border with Rhode Island, hired virtual tutors, conducted home visits and “looked at the crisis as an opportunity to use funds to support students,” said Andrew Rebello, who was principal at the school until this past August.

In 2021, without any diploma expectations waived, the school hit a record 98% graduation rate. Massachusetts, however, just changed those expectations. In the general election, voters decided to scrap the requirement that students pass exams in English, science and math in order to graduate.

The vote is a sign that the shift toward waiving high-stakes tests wasn’t limited to the pandemic.

Harry Felder, executive director of FairTest, which advocates against standardized testing, celebrated the outcome. “Parents, educators and policymakers realize that these tests fail as drivers of education that our young people need to thrive in the modern world.” he said in a press release.

But Rebello, now assistant superintendent in another district, said he thinks the state needs to add a different requirement to “make the diploma meaningful.”

The growing backlash against high-stakes testing also creates the opportunity for a fresh “conversation about what really matters for high school graduation rates,” Balfanz said.

While some research shows that getting good grades and taking rigorous courses might be greater predictors of success in college than a single test score, there are also concerns that grades no longer reflect subject mastery.

“This is a huge debate,” Balfanz said. “But, post-pandemic, we do need to revise what we expect of our kids.”
 

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Younger patients more affected by neurologic manifestations of long COVID
by Elana Gotkine
November 22, 2024

Younger and middle-aged patients seem to be disproportionately affected by neurologic manifestations of postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection (Neuro-PASC), according to a study published online Nov. 22 in the Annals of Neurology.

Natasha A. Choudhury, M.D., from the Northwestern University Feinberg School of Medicine in Chicago, and colleagues conducted a cross-sectional study of the first consecutive 200 posthospitalization Neuro-PASC and 1,100 nonhospitalized Neuro-PASC (NNP) patients assessed at a Neuro-COVID-19 clinic between May 2020 and March 2023. Patients were divided into age groups: younger, middle-aged, and older (18 to 44, 45 to 64, and 65-plus years, respectively).

The researchers found that significant age-related differences in the frequencies of comorbidities and abnormal neurologic findings demonstrated higher prevalence in older patients. Conversely, significant age-related differences in Neuro-PASC symptoms, indicating lower prevalence and symptom burden in older individuals, were seen at 10 months from COVID-19 onset.

In the NNP group, there were significant age-related differences observed in subjective impression of fatigue and sleep disturbance, corresponding with higher impairment in quality of life for younger patients. In NNP patients, significant age-related differences were seen in objective executive function and working memory, with the worst performance seen in younger patients.

"The impact of this condition causing disproportionate morbidity and disability in younger adults in their prime, who provide much of the workforce, productivity, and innovation in our society, may lead to critical issues of increased health care system burden, mental health crisis, socio-cultural deterioration, and economic recession," the authors write.

More information: Natasha A. Choudhury et al. Neurologic Manifestations of Long COVID Disproportionately Affect Young and Middle-Age Adults, Annals of Neurology (2024). DOI: 10.1002/ana.27128, onlinelibrary.wiley.com/doi/10.1002/ana.27128
Journal information: Annals of Neurology
 

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Microscopic, single-cell differences found in the lungs of COVID-19 patients in Malawi

by University of Glasgow
November 20, 2024


microscopic-single-cel.jpg

Study overview, overview of our cohort and comparator cohorts and histological lesion comparison with other cohorts. Credit: Nature Medicine (2024). DOI: 10.1038/s41591-024-03354-3


Microscopic, single-cell differences found in the lungs of COVID-19 patients in Malawi demonstrate the value and importance of cutting-edge infectious disease research in Sub-Saharan Africa.

The new study—the first of its kind in a Sub-Saharan population—is published in Nature Medicine and reveals previously unobserved differences in the inflammatory response to SARS-CoV-2, the virus that causes COVID-19, in patients who live in Malawi, compared to those who live in Western countries. Scientists believe these differences in response to the virus may be linked to both genetic and environmental factors, highlighting the importance of a global approach to infectious disease research.

Led by the University of Glasgow in collaboration with Malawian scientists at the Malawi-Liverpool-Wellcome program and Kamuzu University of Health Sciences and an international research team, the study is the first to carry out single-cell tests in lung samples in any Sub-Saharan population.

To carry out the study, the team undertook a series of postmortem investigations in fatal lung disease patients, with and without COVID-19, in the early stages of the pandemic (2020-21). Seeking to understand how the disease had impacted people in Malawi, the team performed single-cell tests on lung and nasal tissues as well as on blood samples, alongside using imaging mass cytometry—a state-of-the-art imaging technology.

Data from the study showed that broadly, the majority of pathological changes in the lung and some immunological responses in COVID-19 in Malawian patients had similarities to other non-African groups. Researchers say these findings are reassuring, indicating that infection with COVID-19 is not an entirely different disease process when comparing these different patient populations—indicating the likely effectiveness of broad anti-inflammatory treatments like steroids in Malawian patients.

However, looking in more detail at a cellular level, the research team also found marked differences in the Malawian samples compared with other global data, with potential implications for more targeted treatments—indicating that some treatments, which have been fairly widely used, may not be effective in Malawian patients.

The researchers believe both genetic and environmental factors, including lifetime exposure to other locally endemic pathogens such as TB and malaria, may be behind some of the differences in cell responses to the disease. The team say their findings highlight the vital importance of carrying out cutting-edge research across different countries and regions of the world, in order to ensure a fuller picture of human health.

Dr. Christopher Moxon, lead author of the paper from the University of Glasgow, said, "It is great to see the results come together of this major multi-disciplinary team effort. The work had social, logistical as well as technical challenges and it was only through bringing together local and international experts in these areas that this study was possible. Our team has shown that we can apply some of the most cutting-edge techniques in a center in sub–Saharan Africa and produce results with important translational implications. This lays exciting foundations for the future."

James Nyirenda, first author on the paper who carried out the research while at the Malawi-Liverpool-Wellcome program and Kamuzu University of Health Sciences, said, "Our study highlights the need for investing in advanced discovery research in low-income regions. This is not just about scientific innovation; it's also about bringing equal benefits of scientific innovation to under-represented countries for equity.

"By uncovering unique immune responses to COVID-19 in Malawi, our study highlights how targeted immunological research can lead to more effective, accessible treatments for populations that might otherwise be overlooked."

More information: James Nyirenda et al, Spatially resolved single-cell atlas unveils a distinct cellular signature of fatal lung COVID-19 in a Malawian population, Nature Medicine (2024). DOI: 10.1038/s41591-024-03354-3
Journal information: Nature Medicine
Provided by University of Glasgow
 

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New FOIA Emails: NIH Silenced Own Expert on Covid Origin
Jeff Carlson & Hans Mahncke
Nov 22, 2024

The National Institutes of Health (NIH) is hiring a new chief for their virology section. That the federal government should not be hiring anyone, especially not senior staff, during the lame-duck period is self-evident. But what is in many ways even more notable about this appointment is that it reveals that the NIH has a virology section. One certainly could not have guessed this based on the people trotted out by Anthony Fauci during the pandemic, all of whom were from outside the NIH. Curiously, there has been no interest whatsoever from the media as to why that might be, especially since, as we can now all see, the NIH has its own virology branch.

This latest revelation aligns perfectly with newly released emails from January 2021, which gives us an insight into how NIH leadership was not only censoring critical voices in academia, such as that of Jay Bhattacharya, President-elect Trump’s likely pick as new NIH head, but also actively censoring its own experts. In one email, obtained last week by Jimmy Tobias after a years-long Freedom of Information Act battle, Carrie Wolinetz, the senior advisor to the director of the NIH, demanded outright censorship of an in-house NIH expert.

The expert, David Resnick, who works in the NIH’s bioethics section, co-authored a paper discussing the merits (or lack thereof) of gain-of-function experiments. This worried Wolinetz because it might have prompted questions about the origin of Covid and the potential role the NIH may have played in the virus's creation:
“I have some global concerns with the notion that an NIH employee would be providing what amount to critiques of HHS policy that is implemented by NIH, or suggestions that contradict messaging by NIH leadership.”
The “HHS policy” which Wolinetz felt compelled to protect from any criticism, according to her own email, was based on a blog post by her superior, the then head of the NIH, Francis Collins. In his blog post, dated March 26, 2020, Collins expressed his strong opposition to the lab leak theory, which he called “outrageous.” The sole basis for Collins' post was the fraudulent Proximal Origin paper, published just a few days earlier. Collins failed to acknowledge that he, along with Fauci, played a significant role in orchestrating the publication of this fraudulent paper, which explicitly aimed to promote the natural origin theory while discrediting the lab leak theory. Wolinetz's justification for silencing a prominent colleague was so flimsy that the only reasonable conclusion one can draw from her actions is that she was helping Collins and Fauci to cover up their involvement in seeding the pandemic, which included outsourcing gain-of-function experiments on coronaviruses to the Wuhan Institute of Virology.

Notably, Wolinetz’s email had only one recipient: Lawrence Tabak, the then principal deputy director of the NIH, who would soon become the acting director, a position he held until 2023. In his reply, Tabak agreed to meet Wolinetz to talk about silencing Resnik.

Even more notably, it took another three and a half years years for Resnik to finally publish his article in July 2024, by which time the NIH's deceitful natural origin narrative had largely collapsed. In the published article Resnik stated:
“the idea that a biosafety lapse at the WIV—or some other laboratory for that matter—could have caused the COVID-19 pandemic is a very real possibility that has significant bioethical and public policy implications.”
It is no wonder that NIH leadership was so eager to silence him.

The implications of Wolinetz’s actions are significant. She pervasively infringed upon academic freedom, as well as on Resnik’s First Amendment rights. Typically, the media experiences a total meltdown when there is even just a suggestion that a government scientist has been silenced; in this instance, we have airtight evidence that this actually occurred. However, since the scientist in question may have made remarks that could be interpreted as mildly critical of Collins and Fauci, the media has completely overlooked the story.

There are additional implications to consider, and this brings us back to the NIH's recruitment of a new chief virologist. The broader issue, which goes directly to the heart of the Covid origin cover-up, is that despite receiving in excess $60 billion annually from taxpayers and employing over 20,000 staff—many of whom are highly compensated scientists—Collins and Fauci completely disregarded their in-house experts regarding the origins of Covid. Instead, they brought in several conflicted scientists whose careers were entirely dependent on funding from Fauci.

The scientists were subsequently tasked with writing the fraudulent Proximal Origin paper, along with other actions to further the cover-up, such as promoting the false natural origin narrative in the media. Not coincidentally, two of the scientists brought in by Fauci and Collins, Kristian Andersen and Robert Garry, had previously worked in a lab in Kenema, Sierra Leone, which is suspected to be the origin of the Ebola outbreak in 2014. Their expertise in covering up suspected lab leaks may explain why they were chosen. Notably, Andersen had no prior experience with coronaviruses.
These external scientists, employed by Fauci to obscure the true origin of Covid, later collectively received over $50 million in grant allocations from Fauci. Andersen, the lead author of the fraudulent Proximal Origin paper, had an $8.9 million grant awaiting approval on Fauci's desk as he was tasked with leading the cover-up.

As a general proposition, we were already aware that NIH’s own scientists had been excluded from the Covid origin issue. This was evident because the only names that consistently appeared in connection with Fauci and Covid’s origin were those of his hand-picked group of conflicted scientists, who relied on his financial support. However, the full extent of this exclusion was not revealed until the latest batch of emails was obtained. As is often the case in matters of government corruption, particularly regarding the cover-up of Covid's origins, the truth is even worse than we initially believed. Rather than merely ignoring or neglecting internal scientists, they were actively silenced by the director's office.

It cannot be overstated that, although the silencing of Resnik is a serious issue, it is likely just one of many such cases—for which we happen to have obtained incriminating emails. Who else has been silenced? How toxic must the work culture at the NIH be if no one, including Resnik himself, has spoken up?

This entire episode further underscores the urgent need for a total overhaul of the NIH, or perhaps even its complete dissolution. Instead of being dedicated to scientific advancement, the $60 billion organization has become a hub of politics, cover-ups, and corruption. The new Trump administration cannot arrive soon enough.
 

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Trump picks Jay Bhattacharya, who backed COVID herd immunity, to lead National Institutes of Health
Carla K. Johnson
Wed, November 27, 2024 at 2:20 AM UTC

President-elect Donald Trump has chosen health economist Dr. Jay Bhattacharya, a critic of pandemic lockdowns and vaccine mandates, to lead the National Institutes of Health, the nation's leading medical research agency.

Trump, in a statement Tuesday evening, said Bhattacharya, a 56-year-old physician and professor at Stanford University School of Medicine, will work in cooperation with Robert F. Kennedy Jr., his pick to lead the Department of Health and Human Services, "to direct the Nation’s Medical Research, and to make important discoveries that will improve Health, and save lives.”

“Together, Jay and RFK Jr. will restore the NIH to a Gold Standard of Medical Research as they examine the underlying causes of, and solutions to, America’s biggest Health challenges, including our Crisis of Chronic Illness and Disease," he wrote.

The decision to choose Bhattacharya for the post is yet another reminder of the ongoing impact of the COVID pandemic on the politics on public health.

Bhattacharya was one of three authors of the Great Barrington Declaration, an October 2020 open letter maintaining that lockdowns were causing irreparable harm.

The document — which came before the availability of COVID-19 vaccines and during the first Trump administration — promoted “herd immunity,” the idea that people at low risk should live normally while building up immunity to COVID-19 through infection. Protection should focus instead on people at higher risk, the document said.

“I think the lockdowns were the single biggest public health mistake,” Bhattacharya said in March 2021 during a panel discussion convened by Florida Gov. Ron DeSantis.

The Great Barrington Declaration was embraced by some in the first Trump administration, even as it was widely denounced by disease experts. Then- NIH director Dr. Francis Collins called it dangerous and “not mainstream science.”

His nomination would need to be approved by the Senate.

Trump on Tuesday also announced that Jim O’Neill, a former HHS official, will serve as deputy secretary of the sprawling agency. Trump said O’Neill “will oversee all operations and improve Management, Transparency, and Accountability to, Make America Healthy Again,” the president-elect announced.

O’Neill is the only one of Trump’s health picks so far who brings previous experience working inside the bureaucracy to the job. Trump’s previous choices to lead public health agencies — including Kennedy, Dr. Mehmet Oz for Centers for Medicare and Medicaid Services administrator and Dr. Marty Makary for Food and Drug Administration commissioner — have all been Washington outsiders who are vowing to shake up the agencies.

Bhattacharya, who faced restrictions on social media platforms because of his views, was also a plaintiff in Murthy v. Missouri, a Supreme Court case contending that federal officials improperly suppressed conservative views on social media as part of their efforts to combat misinformation. The Supreme Court sided with the Biden administration in that case.

After Elon Musk acquired Twitter in 2022, he invited Bhattacharya to the company's headquarters to learn more about how his views had been restricted on the platform, which Musk renamed X. More recently, Bhattacharya has posted on X about scientists leaving the site and joining the alternative site Bluesky, mocking Bluesky as "their own little echo chamber.”

Bhattacharya has argued that vaccine mandates that barred unvaccinated people from activities and workplaces undermined Americans' trust in the public health system.

He is a former research fellow at the Hoover Institution and an economist at the RAND Corporation.

The National Institutes of Health falls under HHS, which Trump has nominated Kennedy to oversee. The NIH's $48 billion budget funds medical research on vaccines, cancer and other diseases through competitive grants to researchers at institutions across the nation. The agency also conducts its own research with thousands of scientists working at NIH labs in Bethesda, Maryland.

Among advances that were supported by NIH money are a medication for opioid addiction, a vaccine to prevent cervical cancer, many new cancer drugs and the speedy development of mRNA COVID-19 vaccines.
 

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Meet the medical contrarians picked to lead health agencies under Trump and Kennedy
Mike Stobbe, Amanda Seitz, Carla K. Johnson, Matthew Perrone and Erica Hunzinger
November 27, 2024

WASHINGTON (AP) — President-elect Donald Trump has assembled a team of medical contrarians and health care critics to fulfill an agenda aimed at remaking how the federal government oversees medicines, health programs and nutrition.

On Tuesday night, Trump nominated Dr. Jay Bhattacharya to lead the National Institutes of Health, tapping an opponent of pandemic lockdowns and vaccine mandates to lead the nation’s top medical research agency. He is the latest in a string of Trump nominees who were critics of COVID-19 health measures.

Bhattacharya and the other nominees are expected to play pivotal roles in implementing Robert F. Kennedy Jr’s sprawling “Make America Healthy Again,” agenda, which calls for removing thousands of additives from U.S. foods, rooting out conflicts of interest at agencies and incentivizing healthier foods in school lunches and other nutrition programs. Trump nominated Kennedy to head the Department of Health and Human Services, which oversees NIH and other federal health agencies.

The new health priorities bear little resemblance to those of Trump’s first term, which focused on cutting regulations for food, drug and agriculture companies.

“You’re hearing a very different tune as we head into this new Trump administration,” said Gabby Headrick, a nutrition researcher at George Washington University’s school of public health. “It’s important that we all proceed with caution and remember some of the public health losses we saw the first time.”

Trump’s nominees don’t have experience running large bureaucratic agencies, but they know how to talk about health on TV.

Centers for Medicare and Medicaid pick Dr. Mehmet Oz hosted a talk show for 13 years and is a well-known wellness and lifestyle influencer. The pick for the Food and Drug Administration, Dr. Marty Makary, and for surgeon general, Dr. Janette Nesheiwat, had been frequent Fox News contributors.

Some of them have ties to Florida like many of Trump’s other Cabinet nominees: Dave Weldon, the pick for the Centers for Disease Control and Prevention, represented the state in Congress for 14 years.

Here’s a look at how the nominees may carry out Kennedy’s plans to “reorganize” agencies, which have an overall $1.7 trillion budget, employ 80,000 scientists, researchers, doctors and other officials:


National Institutes of Health

The National Institutes of Health, with a $48 billion budget, funds medical research through grants to scientists across the nation and conducts its own research.

Bhattacharya, a health economist and physician at Stanford University, was one of three authors of the Great Barrington Declaration, an October 2020 letter maintaining that lockdowns were causing irreparable harm.

The document — which came before the availability of COVID-19 vaccines — promoted “herd immunity,” the idea that people at low risk should live normally while building up immunity to COVID-19 through infection. Protection should focus instead on people at higher risk, the document said.

“I think the lockdowns were the single biggest public health mistake,” Bhattacharya said in March 2021 during a panel discussion convened by Florida Gov. Ron DeSantis.

The Great Barrington Declaration was embraced by some in the first Trump administration, even as it was widely denounced by disease experts. Then- NIH director Dr. Francis Collins called it dangerous and “not mainstream science.”

His nomination would need to be approved by the Senate.

Kennedy has said he would pause NIH’s drug development and infectious disease research and shift its focus to chronic diseases. He also would like to keep NIH funding from researchers with conflicts of interest. In 2017, he said the agency wasn’t doing enough research into the role of vaccines in autism — an idea that has long been debunked.


Centers for Disease Control and Prevention

The Atlanta-based CDC, with a $9.2 billion core budget, is charged with protecting Americans from disease outbreaks and other public health threats.

Kennedy has long attacked vaccines and criticized the CDC, repeatedly alleging corruption at the agency. He said on a 2023 podcast that there is “no vaccine that is safe and effective,” and urged people to resist the CDC’s guidelines about if and when kids should get vaccinated. The World Health Organization estimates that vaccines have saved more than 150 million lives over the past 50 years, and that 100 million of them were infants.

Decades ago, Kennedy found common ground with Weldon, who served in the Army and worked as an internal medicine doctor before he represented a central Florida congressional district from 1995 to 2009.

Starting in the early 2000s, Weldon had a prominent part in a debate about whether there was a relationship between a vaccine preservative called thimerosal and autism. He was a founding member of the Congressional Autism Caucus and tried to ban thimerosal from all vaccines.

Since 2001, all vaccines manufactured for the U.S. market and routinely recommended for children 6 years or younger have contained no thimerosal or only trace amounts, with the exception of inactivated flu vaccine. Meanwhile, study after study found no evidence that thimerosal caused autism.

Weldon’s congressional voting record suggests he may go along with Republican efforts to downsize the CDC, including to eliminate the National Center for Injury Prevention and Control, which works on topics like drownings, drug overdoses and shooting deaths.


Food and Drug Administration

Kennedy has been extremely critical of the FDA, which has 18,000 employees and is responsible for the safety and effectiveness of prescription drugs, vaccines and other medical products, as well as overseeing cosmetics, electronic cigarettes and most foods.

Makary, Trump’s pick to run the FDA, is a professor at Johns Hopkins University, a trained surgeon and a cancer specialist. He is closely aligned with Kennedy on several topics.

Makary has decried the overprescribing of drugs, the use of pesticides on foods and the influence of pharmaceutical and insurance companies over doctors and government regulators.

Kennedy has suggested he’ll clear out “entire” FDA departments and also recently threatened to fire FDA employees for “aggressive suppression” of a host of unsubstantiated products and therapies, including stem cells, raw milk, psychedelics and discredited COVID-era treatments like hydroxychloroquine.

Makary’s contrarian views during COVID-19 included questioning the need for COVID-19 vaccine boosters in young kids.


Centers for Medicaid and Medicare Services

The agency provides health care coverage for more than 160 million people through Medicaid, Medicare and the Affordable Care Act, and also sets Medicare payment rates for hospitals, doctors and other providers. With a $1.1 trillion budget and more than 6,000 employees, Oz has a massive agency to run if confirmed — and an agency that Kennedy hasn’t talked about much.

While Trump tried to scrap the Affordable Care Act in his first term, Kennedy has not taken aim at it yet.

The Biden administration on Tuesday revealed a new plan to force Medicare and Medicaid to cover weight-loss drugs like Wegovy and Zepbound for many Americans who are obese. Kennedy has opposed the idea, saying government-sponsored insurance programs should instead expand coverage of healthier foods and gym memberships.

Trump said during his campaign that he would protect Medicare, which provides insurance for older Americans. Oz has endorsed expanding Medicare Advantage — a privately run version of Medicare that is popular but also a source of widespread fraud.


Surgeon general

Kennedy doesn’t appear to have said much publicly about what he’d like to see from the surgeon general.

The nation’s top doctor has little administrative power but can influence what counts as a public health danger and what to do about it — suggesting things like warning labels for products and issuing advisories. The current surgeon general, Vivek Murthy, declared gun violence as a public health crisis in June.

Trump’s pick, Nesheiwat, is employed as a New York City medical director with CityMD, a group of urgent care facilities. She also has appeared on Fox News and other TV shows, authored a book on the “transformative power of prayer” in her medical career and endorses a brand of vitamin supplements.
 

Heliobas Disciple

TB Fanatic
(fair use applies)


The COVID Cover-Up: 19 Questions We MUST Answer
Justin Hart
Nov 20, 2024

So here's the deal - remember when "experts" kept telling us what to do during COVID? Turns out they got pretty much everything wrong. Like, spectacularly wrong. We're talking 19 major things they completely screwed up, from how the virus spreads to whether masks actually work (spoiler alert: those cloth masks were basically fashion accessories).

Dr. Fauci is the patron saint of TERRIBLE COVID policies. He was wrong on SO MANY POINTS. It's time to set the record straight.

Did he get anything right?
  • Origin of the disease—wrong
  • Transmission—wrong
  • Asymptomatic spread—wrong
  • PCR testing—wrong
  • Fatality rate—wrong
  • Lockdowns—wrong
  • Community triggers—wrong
  • Business closures—wrong
  • School closures—wrong
  • Quarantining the healthy—wrong
  • Impact on youth—wrong
  • Hospital overload—wrong
  • Plexiglass barriers—wrong
  • Social distancing—wrong
  • Outdoor spread—wrong
  • Masks—wrong
  • Variant impact—wrong
  • Natural immunity—wrong
  • Vaccine efficacy—wrong
  • Vaccine injury—wrong

Last year the Norfolk Group just dropped a bomb of a document laying out all these failures. And it's not just Monday morning quarterbacking - they've got the receipts. Real studies showing how natural immunity was actually legit (while Fauci pretended it didn't exist), data proving schools could've stayed open (looking at you, Sweden), and evidence that maybe, just maybe, locking healthy people in their homes wasn't the brilliant strategy they claimed.

Listen, I'm not here to say "I told you so" (okay, maybe a little), but we need to talk about this. Because if we don't learn from how badly our "experts" messed up, we're just asking for a repeat performance next time around. And honestly? I don't think any of us can handle another round of plexiglass theater and double masking.

Let's break down exactly how they got it wrong, and more importantly, why they kept doubling down even when the evidence said otherwise. Buckle up - this is gonna be a wild ride through the greatest public health face-plant in modern history.

These are the questions WE want answered!


TRANSMISSION
  1. Why did officials insist on surface transmission protocols when evidence showed primarily respiratory spread?
  2. Why weren't hospitals evaluating transmission patterns early to inform policy?
  3. Why did the CDC not conduct studies on actual transmission patterns in schools and workplaces?
  4. Why was outdoor transmission overemphasized despite minimal evidence?
  5. Why weren't transmission studies prioritized to guide evidence-based policies?
ASYMPTOMATIC SPREAD
  1. What evidence supported the claim that asymptomatic spread was a major driver?
  2. Why did health officials emphasize asymptomatic spread without solid data?
  3. Why were resources wasted testing asymptomatic people when they could have focused on symptomatic cases?
  4. How did the emphasis on asymptomatic spread affect public trust when evidence didn't support it?
  5. What data actually existed on true asymptomatic (vs presymptomatic) transmission rates?
PCR TESTING
  1. Why did the CDC insist on developing its own test rather than using WHO's?
  2. Why weren't cycle threshold values standardized or reported?
  3. Why did labs use cycle thresholds up to 40 when this led to false positives?
  4. Why wasn't PCR testing prioritized for high-risk populations early on?
  5. How did high cycle thresholds affect case counts and policy decisions?
FATALITY RATE
  1. Why were infection fatality rates not properly stratified by age from the beginning?
  2. Why were deaths "with COVID" vs "from COVID" not distinguished?
  3. How did inflated fatality rates affect public perception and policy?
  4. Why weren't accurate age-stratified fatality rates clearly communicated?
  5. How did misrepresenting fatality rates affect public trust?
LOCKDOWNS
  1. Why were lockdowns implemented without cost-benefit analysis?
  2. Why were lockdown harms (mental health, delayed medical care, etc.) ignored?
  3. What evidence supported the effectiveness of lockdowns?
  4. Why weren't less restrictive focused protection measures tried first?
  5. How many excess deaths were caused by lockdown policies?
  6. Why weren't regional/seasonal factors considered in lockdown decisions?
COMMUNITY TRIGGERS
  1. Why were arbitrary case numbers used to trigger restrictions?
  2. Why weren't hospital capacity metrics prioritized over case counts?
  3. How were community trigger thresholds determined?
  4. Why weren't triggers adjusted based on actual risk levels?
  5. Why weren't clear exit criteria established for restrictions?
BUSINESS CLOSURES
  1. What evidence supported closing small businesses while keeping large retailers open?
  2. Why weren't occupancy limits tried before full closures?
  3. How many businesses were unnecessarily destroyed?
  4. Why weren't economic impacts weighed against minimal health benefits?
  5. What data supported effectiveness of business closures?
SCHOOL CLOSURES
  1. Why were schools closed despite early evidence of low risk to children?
  2. Why did the US ignore data from European schools that stayed open?
  3. Why weren't the developmental/educational harms to children considered?
  4. How did school closures affect mental health and suicide rates in youth?
  5. Why weren't teachers unions' influence on closure decisions examined?
  6. What evidence supported claims that schools were major transmission vectors?
QUARANTINING THE HEALTHY
  1. Why was mass quarantine implemented without precedent or evidence?
  2. Why weren't focused protection measures tried instead?
  3. What was the cost-benefit analysis of quarantining low-risk groups?
  4. How did mass quarantine affect mental health?
  5. Why weren't vulnerable populations prioritized instead?
IMPACT ON YOUTH
  1. Why weren't developmental impacts on children considered?
  2. How did isolation affect mental health and suicide rates?
  3. What were the educational losses from remote learning?
  4. Why weren't sports/activities preserved for youth wellbeing?
  5. How did masks/distancing affect social development?
  6. What were the impacts on college students' mental health and development?
HOSPITAL OVERLOAD
  1. Why weren't early treatment protocols developed to prevent hospitalizations?
  2. Why were field hospitals built but never used?
  3. How did "flattening the curve" messaging affect hospital preparations?
  4. Why weren't at-risk populations protected to prevent hospitalizations?
  5. What was the actual vs projected hospital capacity usage?
PLEXIGLASS BARRIERS
  1. What evidence supported effectiveness of barriers?
  2. Why weren't airflow patterns considered?
  3. How did barriers affect ventilation?
  4. What was the cost-benefit of barrier installation?
  5. Why weren't barrier recommendations updated when shown ineffective?
SOCIAL DISTANCING
  1. What evidence supported 6-foot distancing?
  2. Why wasn't distancing adjusted based on ventilation/masks/context?
  3. How did arbitrary distance rules affect businesses/schools?
  4. Why wasn't 3-foot distancing considered adequate earlier?
  5. What research supported outdoor distancing requirements?
OUTDOOR SPREAD
  1. Why were outdoor gatherings restricted despite minimal transmission risk?
  2. Why were beaches/parks closed?
  3. Why weren't outdoor activities encouraged as safer alternatives?
  4. How did outdoor restrictions affect mental/physical health?
  5. What evidence supported masks outdoors?
MASKS
  1. Why were mask mandates implemented without RCT evidence?
  2. Why weren't potential harms of masking children considered?
  3. Why were cloth masks promoted despite ineffectiveness?
  4. How did masks affect learning/development in children?
  5. Why weren't mask policies updated when studies showed limited benefit?
  6. Why was natural immunity discounted in mask policies?
VARIANT IMPACT
  1. Why were variants used to justify continued restrictions?
  2. How did variant fears affect vaccine confidence?
  3. Why weren't policies adjusted for milder variants?
  4. How did variant messaging affect public trust?
  5. Why weren't seasonal patterns considered in variant projections?
NATURAL IMMUNITY
  1. Why was natural immunity ignored in policy decisions?
  2. Why were recovered people required to vaccinate?
  3. Why wasn't natural immunity studied more thoroughly?
  4. How did dismissing natural immunity affect public trust?
  5. Why were natural immunity studies from other countries ignored?
VACCINE EFFICACY
  1. Why were initial efficacy claims not properly qualified?
  2. Why wasn't waning efficacy communicated earlier?
  3. How did overselling efficacy affect public trust?
  4. Why weren't breakthrough cases tracked properly?
  5. Why were boosters promoted without clear evidence of benefit?
VACCINE INJURY
  1. Why weren't adverse events properly tracked/investigated?
  2. Why were vaccine injuries downplayed or dismissed?
  3. How did VAERS data interpretation affect public trust?
  4. Why weren't age-stratified risk-benefit analyses conducted?
  5. Why weren't early warning signals investigated more thoroughly?
  6. How did dismissing injuries affect vaccine confidence?
We have a LOT of work to do and THANKFULLY we may have people in charge who are willing to ask these questions!
 

Zoner

Veteran Member
(fair use applies)


Meet the medical contrarians picked to lead health agencies under Trump and Kennedy
Mike Stobbe, Amanda Seitz, Carla K. Johnson, Matthew Perrone and Erica Hunzinger
November 27, 2024

WASHINGTON (AP) — President-elect Donald Trump has assembled a team of medical contrarians and health care critics to fulfill an agenda aimed at remaking how the federal government oversees medicines, health programs and nutrition.

On Tuesday night, Trump nominated Dr. Jay Bhattacharya to lead the National Institutes of Health, tapping an opponent of pandemic lockdowns and vaccine mandates to lead the nation’s top medical research agency. He is the latest in a string of Trump nominees who were critics of COVID-19 health measures.

Bhattacharya and the other nominees are expected to play pivotal roles in implementing Robert F. Kennedy Jr’s sprawling “Make America Healthy Again,” agenda, which calls for removing thousands of additives from U.S. foods, rooting out conflicts of interest at agencies and incentivizing healthier foods in school lunches and other nutrition programs. Trump nominated Kennedy to head the Department of Health and Human Services, which oversees NIH and other federal health agencies.

The new health priorities bear little resemblance to those of Trump’s first term, which focused on cutting regulations for food, drug and agriculture companies.

“You’re hearing a very different tune as we head into this new Trump administration,” said Gabby Headrick, a nutrition researcher at George Washington University’s school of public health. “It’s important that we all proceed with caution and remember some of the public health losses we saw the first time.”

Trump’s nominees don’t have experience running large bureaucratic agencies, but they know how to talk about health on TV.

Centers for Medicare and Medicaid pick Dr. Mehmet Oz hosted a talk show for 13 years and is a well-known wellness and lifestyle influencer. The pick for the Food and Drug Administration, Dr. Marty Makary, and for surgeon general, Dr. Janette Nesheiwat, had been frequent Fox News contributors.

Some of them have ties to Florida like many of Trump’s other Cabinet nominees: Dave Weldon, the pick for the Centers for Disease Control and Prevention, represented the state in Congress for 14 years.

Here’s a look at how the nominees may carry out Kennedy’s plans to “reorganize” agencies, which have an overall $1.7 trillion budget, employ 80,000 scientists, researchers, doctors and other officials:


National Institutes of Health

The National Institutes of Health, with a $48 billion budget, funds medical research through grants to scientists across the nation and conducts its own research.

Bhattacharya, a health economist and physician at Stanford University, was one of three authors of the Great Barrington Declaration, an October 2020 letter maintaining that lockdowns were causing irreparable harm.

The document — which came before the availability of COVID-19 vaccines — promoted “herd immunity,” the idea that people at low risk should live normally while building up immunity to COVID-19 through infection. Protection should focus instead on people at higher risk, the document said.

“I think the lockdowns were the single biggest public health mistake,” Bhattacharya said in March 2021 during a panel discussion convened by Florida Gov. Ron DeSantis.

The Great Barrington Declaration was embraced by some in the first Trump administration, even as it was widely denounced by disease experts. Then- NIH director Dr. Francis Collins called it dangerous and “not mainstream science.”

His nomination would need to be approved by the Senate.

Kennedy has said he would pause NIH’s drug development and infectious disease research and shift its focus to chronic diseases. He also would like to keep NIH funding from researchers with conflicts of interest. In 2017, he said the agency wasn’t doing enough research into the role of vaccines in autism — an idea that has long been debunked.


Centers for Disease Control and Prevention

The Atlanta-based CDC, with a $9.2 billion core budget, is charged with protecting Americans from disease outbreaks and other public health threats.

Kennedy has long attacked vaccines and criticized the CDC, repeatedly alleging corruption at the agency. He said on a 2023 podcast that there is “no vaccine that is safe and effective,” and urged people to resist the CDC’s guidelines about if and when kids should get vaccinated. The World Health Organization estimates that vaccines have saved more than 150 million lives over the past 50 years, and that 100 million of them were infants.

Decades ago, Kennedy found common ground with Weldon, who served in the Army and worked as an internal medicine doctor before he represented a central Florida congressional district from 1995 to 2009.

Starting in the early 2000s, Weldon had a prominent part in a debate about whether there was a relationship between a vaccine preservative called thimerosal and autism. He was a founding member of the Congressional Autism Caucus and tried to ban thimerosal from all vaccines.

Since 2001, all vaccines manufactured for the U.S. market and routinely recommended for children 6 years or younger have contained no thimerosal or only trace amounts, with the exception of inactivated flu vaccine. Meanwhile, study after study found no evidence that thimerosal caused autism.

Weldon’s congressional voting record suggests he may go along with Republican efforts to downsize the CDC, including to eliminate the National Center for Injury Prevention and Control, which works on topics like drownings, drug overdoses and shooting deaths.


Food and Drug Administration

Kennedy has been extremely critical of the FDA, which has 18,000 employees and is responsible for the safety and effectiveness of prescription drugs, vaccines and other medical products, as well as overseeing cosmetics, electronic cigarettes and most foods.

Makary, Trump’s pick to run the FDA, is a professor at Johns Hopkins University, a trained surgeon and a cancer specialist. He is closely aligned with Kennedy on several topics.

Makary has decried the overprescribing of drugs, the use of pesticides on foods and the influence of pharmaceutical and insurance companies over doctors and government regulators.

Kennedy has suggested he’ll clear out “entire” FDA departments and also recently threatened to fire FDA employees for “aggressive suppression” of a host of unsubstantiated products and therapies, including stem cells, raw milk, psychedelics and discredited COVID-era treatments like hydroxychloroquine.

Makary’s contrarian views during COVID-19 included questioning the need for COVID-19 vaccine boosters in young kids.


Centers for Medicaid and Medicare Services

The agency provides health care coverage for more than 160 million people through Medicaid, Medicare and the Affordable Care Act, and also sets Medicare payment rates for hospitals, doctors and other providers. With a $1.1 trillion budget and more than 6,000 employees, Oz has a massive agency to run if confirmed — and an agency that Kennedy hasn’t talked about much.

While Trump tried to scrap the Affordable Care Act in his first term, Kennedy has not taken aim at it yet.

The Biden administration on Tuesday revealed a new plan to force Medicare and Medicaid to cover weight-loss drugs like Wegovy and Zepbound for many Americans who are obese. Kennedy has opposed the idea, saying government-sponsored insurance programs should instead expand coverage of healthier foods and gym memberships.

Trump said during his campaign that he would protect Medicare, which provides insurance for older Americans. Oz has endorsed expanding Medicare Advantage — a privately run version of Medicare that is popular but also a source of widespread fraud.


Surgeon general

Kennedy doesn’t appear to have said much publicly about what he’d like to see from the surgeon general.

The nation’s top doctor has little administrative power but can influence what counts as a public health danger and what to do about it — suggesting things like warning labels for products and issuing advisories. The current surgeon general, Vivek Murthy, declared gun violence as a public health crisis in June.

Trump’s pick, Nesheiwat, is employed as a New York City medical director with CityMD, a group of urgent care facilities. She also has appeared on Fox News and other TV shows, authored a book on the “transformative power of prayer” in her medical career and endorses a brand of vitamin supplements.
Well, I like Kenndey and Bhattacharya. Hopefully, Kennedy will have long talks with all of these health appointees and they can learn the truth about Big Pharma and their poisonous vaccines, medicines and drugs. As long as they give us the freedom to choose ... that's all I ask. But I'm expecting a BIG education of the public at large through RFK Jr.
 

Heliobas Disciple

TB Fanatic
(fair use applies)


Genetic clues explain why children develop rare post-COVID condition
by Ryan O'Hare, Imperial College London
November 25, 2024


genetic-clues-explain.jpg

Proposed role of BTNL8 in MIS-C. Credit: Journal of Experimental Medicine (2024). DOI: 10.1084/jem.20240699


Scientists have uncovered genetic variants that help to explain why some children with mild COVID-19 go on to develop a severe inflammatory condition weeks after their infection.

Throughout the COVID-19 pandemic, severe SARS-CoV-2 infections in children and infants were rare. But an estimated 1 in 10,000 children went on to develop multisystem inflammatory syndrome in children (MIS-C), presenting with a range of symptoms including rash, swelling and nausea and vomiting.

Now, an international team of researchers led by Imperial College London has identified a gene that may explain why some children were at greater risk of developing this rare condition. The study is published in the Journal of Experimental Medicine.

In an analysis including more than 150 cases of MIS-C from Europe and the United States, they found that rare variations of a gene that helps regulate the lining of the gut made children four-times more likely to develop systemic inflammation and an array of symptoms.

According to the researchers, understanding the genetic basis of MIS-C provides new insights into how the condition develops, who is at risk, and how patients and those with related conditions might be better treated.

Senior author Dr. Vanessa Sancho-Shimizu, from the Department of Infectious Disease at Imperial College London and The Francis Crick Institute, said, "MIS-C was a very worrying condition for children and their families as well as the clinical teams treating them. Thankfully, the majority of patients recovered, but the underlying mechanisms that drive this condition have been difficult to pin down.

"Working with colleagues around the world, we've been able to pinpoint rare genetic variants that we think are likely driving the systemic inflammation we've seen, making children more susceptible to MIS-C. We hope these findings will not only enable us to better understand the condition but to improve how we care for children with these types of conditions."

Genetic analysis

During the COVID-19 pandemic, evidence suggested children were generally at very low risk of severe disease. But reports emerged of a new condition that affected a small proportion of children several weeks after their infection with SARS-CoV-2.

These children generally had mild or no symptoms at the time of their initial infection. But within six weeks they went on to develop a range of symptoms, including abdominal pains and vomiting, fever, rash and more. Clinicians initially reported the symptoms as resembling Kawasaki disease, but it was found to be a new condition call MIS-C .

In the latest analysis, 154 patients aged 0–19 with MIS-C were recruited in Europe and through a research center in the United States, with blood samples used to sequence patients' genomes. Researchers then developed a technique to search for genetic variants that might be associated with the condition.

Dr. Evangelos Bellos, first author of the paper and a Research Fellow in Imperial's Department of Infectious Disease, said, "Our new computational technique, which we call burdenMC, gives us the power to identify links between genes and diseases that were previously elusive. It is particularly useful for shedding light on small, diverse groups of patients with rare conditions such as MIS-C."

Using this approach, the researchers found that small changes in one gene, called BTNL8, were a common factor in children with the condition. Typically, this gene helps to regulate the immune cells in the gut lining, but in patients with MIS-C, rare variants of BTNL8 are believed to have made the gut more sensitive to the SARS-CoV-2 virus and increased inflammation throughout the body, leading to an array of symptoms.

The team worked with the Immunosurveillance Laboratory at the Crick, led by Professor Adrian Hayday, that first identified a function for BTNL8 in the human gut as a regulator of localized T-cells that seemed to contribute to maintaining gut barrier integrity.

Professor Adrian Hayday, Principal Group Leader at the Crick and Professor of Immunobiology at King's College London, said, "The discoveries implicating BTNL8 were wholly unexpected, and potentially offer entirely new insights into mechanisms that ordinarily prevent virus infections from leading to life-threatening disease."

Compared with matched healthy controls, patients with rare BTNL8 variants had a four-fold increase in the risk of developing MIS-C symptoms. The analysis also found that children with European and Hispanic ancestry were more likely to have the variants, and so were at greater risk of the condition.

The researchers say they are now working on understanding the exact mechanisms by which these rare variants promote MIS-C. They are also exploring if the gut also plays an important role in the development of other similar childhood inflammatory conditions like Kawasaki disease.

More information: Evangelos Bellos et al, Heterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children (MIS-C), Journal of Experimental Medicine (2024). DOI: 10.1084/jem.20240699
Journal information: Journal of Experimental Medicine
Provided by Imperial College London
 

Heliobas Disciple

TB Fanatic
(fair use applies)


Air pollution linked to longer duration of long-COVID symptoms
by Barcelona Institute for Global Health
November 27, 2024

Exposure to air pollutants (PM2.5 and PM10) is associated with an increased risk of persistent long-COVID symptoms, partly due to its impact on the severity of the acute infection.

This is the main conclusion of a study led by the Barcelona Institute for Global Health (ISGlobal), a center supported by "la Caixa" Foundation, in collaboration with the Germans Trias i Pujol Research Institute (IGTP), and published in Environmental Health Perspectives.

Long-COVID is a heterogeneous condition in which symptoms like fatigue, breathlessness, and cognitive issues persist for months after a COVID-19 infection and cannot be explained by other diagnoses. The real burden of long-COVID remains unclear, but millions of people are estimated to be affected worldwide. Its risk factors are also not well understood, since even people with mild or no symptoms during acute infection can develop long-COVID.

"We previously found that air pollution exposure is linked to a higher risk of severe COVID-19 and a lower vaccine response, but there are very few studies on long-COVID and the environment," explains Manolis Kogevinas, ISGlobal researcher and senior author of the study.

In this study, he and his colleagues investigated whether air pollution and other environmental exposures such as noise, artificial light at night, and green spaces, were associated with the risk- or persistence- of Long-COVID.

The study followed over 2,800 adults of the COVICAT cohort, aged 40–65 years living in Catalonia who during the pandemic completed three online questionnaires (2020, 2021, 2023).

These surveys collected information on COVID-19 infections, vaccination status, health status, and sociodemographic data. Researchers estimated residential exposure to noise, particulate matter, ozone, nitrogen dioxide, green spaces, and light at night for each participant.


Long-COVID risk factors


The analysis showed that one in four people who contracted COVID-19 experienced lingering symptoms for three months or more, with 5% experiencing persistent symptoms for two years or more. Women, individuals with lower education levels, those with prior chronic conditions, and those who had severe COVID-19 were at highest risk of long-COVID.

Vaccination, on the other hand, made a positive difference: only 15% of vaccinated participants developed long-COVID compared to 46% of unvaccinated ones.


Air pollution and persistent long-COVID

Exposure to particulate matter (PM2.5 and PM10) in the air was associated with a slight increase in the risk of persistent long-COVID (i.e. people who reported long-COVID in 2021 and whose symptoms were still present the last week before the 2023 interview).

The risk of persistent long-COVID increased linearly with greater exposure to particulate matter in the air. In contrast, factors such as nearby green spaces or traffic noise showed little impact on long-COVID.

The researchers note that while air pollution may not directly cause long-COVID, it could increase the severity of the initial infection, which, in turn, raises the risk of long COVID.

"This hypothesis is supported by the association between particulate matter and the most severe and persistent cases of long-COVID, but not with all cases of long-COVID," says Apolline Saucy, first author of the study.

Further research is needed to break down the different types of long-term symptoms and get a more detailed picture of how environmental factors might play a role.

"This type of study is particularly relevant as more people continue to recover from COVID-19 and deal with its potential long-term effects," says Kogevinas.

More information: Saucy A, et al. Environmental exposures and Long-COVID in a Prospective Population-Based Study in Catalonia (COVICAT study), Environmental Health Perspectives (2024). DOI: 10.1289/EHP15377
Journal information: Environmental Health Perspectives
Provided by Barcelona Institute for Global Health
 

Heliobas Disciple

TB Fanatic
(fair use applies)


New Wearable Device Eases Long COVID Pain and Fatigue
By University of California - Los Angeles Health Sciences
November 28, 20241

Researchers report that the wearable TENS system provided “immediate, on-demand relief.”

A study co-led by researchers from UCLA and Baylor College of Medicine suggests that a wearable device for electrical nerve stimulation may help alleviate persistent pain and fatigue associated with long COVID.

Long-COVID, a complex and lingering condition following COVID-19 recovery, affects approximately 1 in 13 adults in the U.S. Symptoms such as widespread pain, fatigue, and muscle weakness often continue to disrupt daily activities, including walking and basic tasks.

The study, published in the peer-reviewed Nature Scientific Reports, focused on a wearable Transcutaneous Electrical Nerve Stimulation (TENS) device, which uses low-voltage electrical currents to reduce pain, fatigue, and mobility issues associated with long COVID.


Broader Potential Applications

The project was co-led by Dr. Bijan Najafi, research director of the Center for Advanced Surgical & Interventional Technology at UCLA Health and co-director of NSF IUCRC Center to Stream HealthCare in Place (C2SHIP), who said the device could have wider applications.

“While this study focused on managing pain and fatigue caused by long COVID, it may also have potential applications for addressing similar symptoms in individuals with other respiratory diseases, those who have experienced extended ICU stays and developed post-hospitalization weaknesses, and conditions involving chronic fatigue and pain, such as fibromyalgia or chemotherapy-related side effects,” Najafi said. “But further studies are needed to confirm these potential uses.”

In the study, 25 participants with chronic musculoskeletal pain, fatigue, and gait difficulties were assigned either a high-dose (active) TENS device or a low-dose (placebo) device. Both groups used the TENS device for three to five hours daily over a four-week period.

Researchers measured participants’ pain levels, fatigue, and walking performance before and after the therapy period. Findings indicated that the high-dose TENS group experienced notable improvements in pain relief (26.1% more relief compared to placebo) and walking ability (8% during fast walking), suggesting that wearable TENS therapy may help reduce long COVID’s impact on daily life.

The high-dose TENS group also reported a slightly higher perceived benefit (71.2%) compared to the low-dose group (61.4%), underscoring the potential of wearable TENS technology to support long COVID recovery.


Importance of Wearable Technology


One factor in the study’s success was likely the high rate of daily device usage, Najafi said. The wearable nature of the TENS device allowed participants to use it seamlessly throughout the day, without disrupting their routines.

“This wearable TENS system offered immediate, on-demand relief from pain and fatigue, making it easy to integrate into daily activities,” Najafi said.

He also cautioned that more research is needed. This study provides some hope for finding an effective, non-invasive solution for managing lingering COVID-19 symptoms that continue to affect millions,” he said. “But our sample size was limited, so further research is needed to confirm these findings.”

Reference: “Transcutaneous electrical nerve stimulation for fibromyalgia-like syndrome in patients with Long-COVID: a pilot randomized clinical trial” by Alejandro Zulbaran-Rojas, Rasha O. Bara, Myeounggon Lee, Miguel Bargas-Ochoa, Tina Phan, Manuel Pacheco, Areli Flores Camargo, Syed Murtaza Kazmi, Mohammad Dehghan Rouzi, Dipaben Modi, Fidaa Shaib and Bijan Najafi, 8 November 2024, Scientific Reports.
DOI: 10.1038/s41598-024-78651-5

Study co-authors are Alejandro Zulbaran-Rojas, Rasha Bara, Myeounggon Lee, Miguel Bargas-Ochoa, Tina Phan, Manuel Pacheco, Areli Flores Camargo, Syed Murtaza Kazmi, Mohammad Dehghan Rouzi, Dipaben Modi, and Fidaa Shaib of Baylor College of Medicine.

This study was funded by the National Science Foundation’s Industry-University Cooperative Research Centers (IUCRC), specifically from the Center to Stream HealthCare in Place (C2SHIP), with award numbers NSF 2052514 and C2SHIP Y01-BCM-008. There was also in-kind support provided by Neurometrix Inc., which manufactured the Quell® TENS device.
 

Shadow

Swift, Silent,...Sleepy
At the same time that he is saying that the fed government mandated the vax for commercial pilots the FAA regulations prohibit a commercial pilot from taking any drug that is not approved. Emergency use is not approval. Once a drug is approved commercial pilots are not allowed to take it for a year after the approval.

This whole thing has been screwed up from the beginning. So much so that intentional harm is the only logical explanation.

Shadow
 

Heliobas Disciple

TB Fanatic
(fair use applies)


Long COVID appears to be driven by 'long infection.' Here's what the science says
by Brendan Crabb, Gabriela Khoury and Michelle Scoullar, The Conversation
November 29, 2024

Around 5%–10% of people with COVID infections go on to experience long COVID, with symptoms lasting three months or more.

Researchers have proposed several biological mechanisms to explain long COVID. However, in a perspective article published in the latest Medical Journal of Australia, we argue that much, if not all, long COVID appears to be driven by the virus itself persisting in the body.

Since relatively early in the pandemic, there has been a recognition that in some people, SARS-CoV-2—or at least remnants of the virus—could stay in various tissues and organs for extended periods. This theory is known as "viral persistence."

While the long-term presence of residual viral fragments in some people's bodies is now well established, what remains less certain is whether the live virus itself, not just old bits of virus, is lingering—and if so, whether this is what causes long COVID. This distinction is crucial because the live virus can be targeted by specific antiviral approaches in ways that "dead" viral fragments cannot.

Viral persistence has two significant implications:
  1. When it occurs in some highly immunocompromised people, it is thought to be the source of new and substantially different-looking variants, such as JN.1
  2. It has the potential to continue to cause symptoms in many people in the wider population long beyond the acute illness. In other words, long COVID could be caused by a long infection.

What does the research say?


While there remains no single study that confirms that persistent virus is the cause of long COVID, collectively several recent key papers make a compelling case.

In February, a study in Nature found a high number of people with mild COVID symptoms had extended periods of shedding the genetic material of the virus, so-called viral RNA, from their respiratory tract. Those with persistent shedding of this viral RNA—which almost certainly represents the presence of live virus—were at higher risk of long COVID.

Other key papers detected replicating viral RNA and proteins in blood fluid of patients years after their initial infection, a sign that the virus is likely replicating for long periods in some hidden reservoirs in the body, perhaps including blood cells.

Another study detected viral RNA in ten different tissue sites and blood samples 1–4 months after acute infection. This study found the risk of long COVID (measured four months following infection) was higher in those with persistently positive viral RNA.

The same study also gave clues about where in the body the persisting virus resides. The gastrointestinal tract is one site of considerable interest as a long-term viral hideout.

Earlier this week, further evidence of persistent virus increasing likelihood of long COVID has been published as part of the RECOVER initiative, a collaborative research project that aims to address the impacts of long COVID.

However, formal proof that virus capable of replicating can last for years in the body remains elusive. This is because isolating the live virus from reservoirs inside the body where the virus "hides" is technically challenging.

In its absence, we and other scientists argue the cumulative evidence is now sufficiently compelling to galvanize action.


What needs to happen next?

The obvious response to this is to fast-track trials of known antivirals for prevention and cure of long COVID.

This should include more left-field therapies such as the diabetes drug metformin. This has possible dual benefits in the context of long COVID:
  • its antiviral properties, which have demonstrated surprising efficacy against long COVID
  • as a potential therapeutic in treating impairments related to fatigue.
However, another major thrust should be the development of new drugs and the establishment of clinical trial platforms for rapid testing.

Science has uncovered exciting therapeutic options. But translating these into forms usable in the clinic is a large hurdle that requires support and investment from governments.


Demystify and preventing long COVID

The notion of "long infection" as a contributor or even the driver of long COVID is a powerful message. It could help demystify the condition in the eyes of the wider community and increase awareness among the general public as well as medical professionals.

It should help raise awareness in the community of the importance of reducing rates of re-infection. It is not just your first infection, but each subsequent COVID infection carries a risk of long COVID.

Long COVID is common and isn't restricted to those at high risk of severe acute disease but affects all age groups. In one study, the highest impact was in those aged 30 to 49 years.

So, for now, we all need to reduce our exposure to the virus with the tools available, a combination of:
  • clean indoor air approaches. In its simplest form, this means being conscious of the importance of well-ventilated indoor spaces, opening the windows and improving airflow as COVID spreads through air. More sophisticated ways of ensuring indoor air is safe involve monitoring quality and filtering air in spaces that cannot be easily naturally ventilated
  • using high-quality masks (that are well-fitting and don't let air in easily, such as N95-type masks) in settings where you don't have confidence of the quality of the indoor air and/or that are crowded
  • testing, so you know when you're positive. Then, if you're eligible, you can get treatment. And you can be vigilant about protecting those around you with masks, staying at home where possible, and ventilating spaces
  • staying up to date with COVID booster doses. Vaccines reduce long COVID and other post-COVID complications.
Hopefully one day there will be better treatments and even a cure for long COVID. But in the meantime, increased awareness of the biomedical basis of long COVID should prompt clinicians to take patients more seriously as they attempt to access the treatments and services that already exist.
Journal information: Nature
 

Heliobas Disciple

TB Fanatic
(fair use applies)


COVID Cases and Hospitalizations Rising in Victoria, Australia as Holidays Approach
Nikhil Prasad Fact checked by:Thailand Medical News Team
Dec 01, 2024

Victoria is witnessing a sharp increase in COVID-19 infections and hospitalizations, sparking health warnings as residents prepare for the festive season. The state has reported a 63% rise in cases over the past month, with the seven-day average for hospitalizations now at 194 - up 12% from the previous week. Health authorities urge residents to take precautions to curb the spread, especially among vulnerable populations such as the elderly, those with chronic conditions, and Aboriginal and Torres Strait Islander communities.

In the week previous week there were a total of 1,597 lab-confirmed COVID-19 infections.


As the holiday season encourages more gatherings, the state’s Chief Health Officer, Dr. Clare Looker, emphasized the importance of vigilance. She advised Victorians to stay home if unwell, wear masks when visiting sensitive settings, and consider meeting outdoors or in well-ventilated spaces. This Medical News report provides details on how to protect yourself and others during this critical period.


Key Symptoms and What to Watch For

COVID-19 symptoms can range from mild to severe and typically appear 1–14 days after exposure. Common signs include runny nose, sore throat, cough, fever, and chills. Others may experience fatigue, muscle soreness, nausea, vomiting, diarrhea, and loss of smell or taste. If you feel unwell, even with mild symptoms, health experts recommend taking a rapid antigen test (RAT) and isolating until symptoms subside.


Protecting Yourself and Vulnerable Communities
Health officials have outlined six key steps to help reduce transmission:

-Stay Home if Sick: Avoid public spaces if you have cold or flu-like symptoms. Consult your GP if symptoms worsen.

-Test for COVID-19: Use RAT kits if you exhibit symptoms. Positive cases should isolate until symptom-free and avoid sensitive settings for at least seven days.

-Wear Masks: High-quality masks can protect both you and others, especially in crowded or high-risk settings.

-Improve Ventilation: Open windows or meet outdoors when possible to reduce the spread of the virus.

-Consider Antivirals: Eligible individuals at high risk of severe illness should consult their GP about COVID-19 antiviral medications, which are most effective when taken within five days of symptom onset.


Rising Numbers Highlight the Issue

Recent surveillance data confirms that COVID-19 activity in Victoria is increasing significantly. The weekly average hospitalization rate has climbed, and there has been a marked increase in laboratory-confirmed cases. Health authorities are closely monitoring these trends and providing guidance to healthcare facilities and public health organizations to address the surge.


Recommendations for the Holiday Season
Dr. Looker stressed the importance of safeguarding those most vulnerable to severe illness, particularly as gatherings become more frequent. “Immunity wanes over time, so staying up to date with vaccinations remains the best defense against severe disease,” she noted. Residents are encouraged to discuss eligibility for antivirals with their healthcare providers and adhere to public health recommendations.

To further mitigate risks, individuals are advised to avoid visiting hospitals or aged-care facilities if they show any symptoms of respiratory infection. Organizations serving high-risk groups are also encouraged to implement measures that reduce transmission in these environments.


Concluding Thoughts

The rise in COVID-19 cases across Victoria serves as a reminder that the pandemic is not over. While vaccines and treatments have significantly improved outcomes, the virus continues to pose a threat, particularly to vulnerable groups. Protecting oneself and others requires collective action - staying home when unwell, testing when symptomatic, and following public health advice. Taking these steps will not only reduce the burden on healthcare systems but also ensure safer celebrations during the holiday season.
 

Heliobas Disciple

TB Fanatic
(fair use applies)


Study Warns Silent Spread of COVID-19 is More Extensive Than Thought, Driven by Asymptomatic Infections

Nikhil Prasad Fact checked by:Thailand Medical News Team
Dec 02, 2024

As the COVID-19 pandemic continues to impact lives globally, a groundbreaking study sheds light on an unsettling reality: the virus may be spreading silently and more extensively than previously understood, largely due to asymptomatic infections. This revelation comes from a detailed observational study conducted in Bahrain by researchers affiliated with the National Taskforce for Combating the Coronavirus, Mohammed Bin Khalifa Cardiac Centre, the Royal College of Surgeons in Ireland (Bahrain), and the Bahrain Defence Force Hospital.


Understanding Silent Spread
The study highlights the hidden threat posed by asymptomatic individuals - those infected with SARS-CoV-2 but showing no symptoms. According to the researchers, who analyzed data from 320 confirmed "index" cases and 1,289 positive contacts, about 50% of the initial cases were asymptomatic. Among the contacts of these cases, a staggering 87.4% also displayed no symptoms. These findings emphasize that asymptomatic transmission might play a more significant role in the pandemic than previously estimated.

This Medical News report underscores that the prevalence of asymptomatic carriers, coupled with their potential to infect others, challenges the traditional focus on symptomatic individuals in public health strategies. Relying solely on symptom-based detection methods may leave a significant portion of infections unnoticed, fueling the virus's spread.


Key Findings of the Study
-Demographics and Age-Related Insights

A closer look at the demographic data reveals that males constituted the majority of both index cases (74.1%) and their contacts (69.2%). Interestingly, young individuals (ages 0-19) were more susceptible as contacts, representing 20.8% of cases in this group compared to just 4.7% of index cases. This indicates that children and adolescents may be significant contributors to the silent spread, despite often being less symptomatic or less severely affected by the disease.

The most affected age group among index cases was 30-39 years, which aligns with the working-age population. This group not only represented the largest proportion of cases but also had the highest likelihood of transmitting the virus to household contacts, including younger family members.

-Symptom Status and Transmission Rates
The study found no significant difference in the number of individuals infected by symptomatic versus asymptomatic index cases. On average, both groups infected approximately four individuals each. Moreover, the infectivity rates, calculated as the proportion of contacts who tested positive, were almost identical for symptomatic (39.3%) and asymptomatic (38.3%) index cases. These findings suggest that asymptomatic individuals are just as capable of spreading the virus as those with symptoms.

-Viral Load and PCR Findings
PCR testing provided insights into the viral loads of symptomatic and asymptomatic individuals, as indicated by cycle threshold (Ct) values. While symptomatic cases generally had lower Ct values (indicating higher viral loads), the difference was not sufficient to explain variations in transmission rates. Notably, even individuals with higher Ct values (lower viral loads) were capable of infecting others, challenging the assumption that viral load correlates directly with infectivity.


Implications for Public Health
The study's findings highlight the critical need to rethink public health strategies. Asymptomatic transmission, often overlooked, represents a substantial challenge in controlling the pandemic. Traditional methods, such as temperature checks and symptom-based testing, may not effectively identify all cases. Comprehensive testing and contact tracing, regardless of symptom presence, are crucial to mitigating the silent spread of the virus.

Moreover, the disproportionate impact on specific demographics, such as young people and working-age adults, underscores the importance of targeted interventions. Encouraging universal masking, social distancing, and random community testing can help identify and isolate asymptomatic carriers before they unknowingly spread the virus.


Conclusion
The study conducted in Bahrain serves as a wake-up call for policymakers and public health officials worldwide. By revealing the extent of asymptomatic transmission, it underscores the urgency of adopting more inclusive and proactive measures to combat COVID-19. As the researchers conclude, "Globally, asymptomatic transmission should be urgently addressed in addition to symptomatic transmission."

The study findings were published in the peer-reviewed International Journal of Infectious Diseases.

 

jward

passin' thru
probably deserves it's own thread- or heck, to be shouted from the rooftops as people are lined up and executed against pockmarked walls!- but the American attention span doesn't support the follow up/through, so I'll tuck it here...

Eric Daugherty
@EricLDaugh

#BREAKING: The House COVID Committee has released its final report after a 2-year investigation.

MAJOR FINDINGS:
- The NIH funded gain-of-function research at the Wuhan lab.
- The Constitution can't be suspended in times of crisis.
- COVID emerging from a lab leak is "not a conspiracy theory."
- EcoHealth and Dr. Peter Daszak should "never again" receive taxpayer funds.
- Public health officials have lost the trust of the people.
- Trump's Operation Warp Speed was a success.
- The COVID response was "rampant" with fraud, waste and abuse.
- "The prescription cannot be worse than the disease," lockdowns had horrific consequences.
View: https://twitter.com/EricLDaugh/status/1863653926203019384
 

jward

passin' thru
1733181895933.png
probably deserves it's own thread- or heck, to be shouted from the rooftops as people are lined up and executed against pockmarked walls!- but the American attention span doesn't support the follow up/through, so I'll tuck it here...

Eric Daugherty
@EricLDaugh

#BREAKING: The House COVID Committee has released its final report after a 2-year investigation.

MAJOR FINDINGS:
- The NIH funded gain-of-function research at the Wuhan lab.
- The Constitution can't be suspended in times of crisis.
- COVID emerging from a lab leak is "not a conspiracy theory."
- EcoHealth and Dr. Peter Daszak should "never again" receive taxpayer funds.
- Public health officials have lost the trust of the people.
- Trump's Operation Warp Speed was a success.
- The COVID response was "rampant" with fraud, waste and abuse.
- "The prescription cannot be worse than the disease," lockdowns had horrific consequences.
View: https://twitter.com/EricLDaugh/status/1863653926203019384
 

jward

passin' thru
David it Up!
@Dave_it_up
ALERT
Very Significant Study on Long Covid Brain Damage: How COVID-19’s Spike Protein Affects the Brain, via Skull Bone Marrow Infection

COVID-19 has always been one of complexity, but within its long narrative, one chilling chapter is emerging—the role of our own bones in harboring the virus’s remnants. Hidden deep in the marrow of our skulls, the virus’s spike protein quietly lingers, affecting the brain in ways that are only now being unraveled.

When COVID-19 first swept through the world, attention was fixed on the deaths in China ,and Italy, Recently, we have learned, it significantly damaged our immune system.

Months have turned into to years, and it has felt the virus proved it could strike deeper and leave scars that outlast us.

It has been five years, but this study is a very significant finding, probably the among these scars, neurological symptoms—brain fog, memory issues, and strokes—stand out. Yet how the virus leaves its mark on the brain has been a stubborn puzzle. This new study by et al., published in Cell Host & Microbe, offers a critical piece: the virus’s spike protein doesn’t just disappear. It stays, nestled in the skull marrow, traveling through the meninges, and interacting with brain tissue.

The Bone-Brain Connection
Your bones are alive. Inside them, marrow produces blood cells and plays an essential role in immunity. But when SARS-CoV-2 enters this sanctuary, it’s like letting a wolf into the fold. The study reveals that spike protein accumulates in the skull’s bone marrow, then creeps into the meninges—the protective layers surrounding the brain—and even penetrates the brain itself.

This persistence causes a cascade of damage. The spike protein triggers neuroinflammation, sparking an immune response that harms the brain’s delicate tissues. It’s a silent invasion, and over time, it leaves the brain more vulnerable to other injuries, like strokes and traumatic brain injuries, compounding the damage.

This isn’t the first time bone marrow has been implicated in COVID-19’s long-term effects. Other studies have shown that COVID-19 disrupts hematopoiesis—the process of blood cell formation—in the bone marrow. Research in Nature Communications and The Journal of Clinical Investigation links these disruptions to clotting disorders and lingering immune dysfunction. It seems the bone marrow isn’t just collateral damage; it’s a reservoir, a hiding spot where the virus’s ghost haunts the body long after the acute infection.

The Toll on the Brain
In this latest study, researchers found evidence of spike protein in the brain tissue of both humans and mice. In mice, even injecting the spike protein alone (without the virus) was enough to induce inflammation, neuronal stress, and anxiety-like behaviors. It exacerbated neurological damage after strokes and brain injuries, showing how

the presence of this protein primes the brain for harm.
In humans, cerebrospinal fluid from Long COVID patients revealed elevated biomarkers of neurodegeneration, including Tau and neurofilament light chain (NfL). These are the kinds of changes you’d expect to see in Alzheimer’s disease, not after a viral infection.

Proteomic analyses further detailed how spike protein alters key brain pathways, including those involved in immune activation, blood-brain barrier integrity, and even neuronal signaling. The picture emerging is one of long-term dysfunction—a brain thrown out of balance by the lingering presence of a protein that should have been cleared.

The Hope of Vaccination
There is a glimmer of hope. The study shows that vaccination helps reduce the spike protein’s burden. Mice vaccinated with an mRNA vaccine before infection had significantly lower levels of spike protein in their skull marrow, meninges, and brain compared to unvaccinated mice. The vaccinated animals also showed less inflammation and fewer signs of neurological damage.

This aligns with other studies. Research published in Nature Medicine has shown that vaccinated individuals are less likely to develop Long COVID symptoms, particularly neurological ones. By priming the immune system to recognize and clear the virus more effectively, vaccines appear to limit the lingering presence of its harmful components.

A New Frontier
What does this mean for the millions living with Long COVID? First, it’s a call to action for further research. The study highlights the need to target these reservoirs of viral protein, whether through treatments that enhance clearance or therapies that calm the inflammation they cause.

Second, it’s a reminder of the interconnectedness of the body. That a problem in the bone marrow could ripple into the brain isn’t entirely surprising—medicine has long known that bone health and brain health are linked. But COVID-19 is forcing us to rethink these relationships in ways that could reshape how we treat post-viral illnesses.

Finally, it’s a message of hope. While the damage COVID-19 causes is real and profound, the tools to fight it are within reach. Vaccination is already making a difference, and understanding the spike protein’s journey from bone to brain may lead us to even more precise interventions.

COVID-19 isn’t just a respiratory virus; it’s a systemic invader. And while we’re only beginning to understand its effects, each new discovery brings us closer to reclaiming the lives it has disrupted. The bones beneath our skin may tell the story of how this virus lingers, but they also hold clues to how we might finally defeat it.
http://cell.com/cell-host-micr…


 

Heliobas Disciple

TB Fanatic
David it Up!
@Dave_it_up
ALERT
Very Significant Study on Long Covid Brain Damage: How COVID-19’s Spike Protein Affects the Brain, via Skull Bone Marrow Infection

COVID-19 has always been one of complexity, but within its long narrative, one chilling chapter is emerging—the role of our own bones in harboring the virus’s remnants. Hidden deep in the marrow of our skulls, the virus’s spike protein quietly lingers, affecting the brain in ways that are only now being unraveled.

When COVID-19 first swept through the world, attention was fixed on the deaths in China ,and Italy, Recently, we have learned, it significantly damaged our immune system.

Months have turned into to years, and it has felt the virus proved it could strike deeper and leave scars that outlast us.

It has been five years, but this study is a very significant finding, probably the among these scars, neurological symptoms—brain fog, memory issues, and strokes—stand out. Yet how the virus leaves its mark on the brain has been a stubborn puzzle. This new study by et al., published in Cell Host & Microbe, offers a critical piece: the virus’s spike protein doesn’t just disappear. It stays, nestled in the skull marrow, traveling through the meninges, and interacting with brain tissue.

The Bone-Brain Connection
Your bones are alive. Inside them, marrow produces blood cells and plays an essential role in immunity. But when SARS-CoV-2 enters this sanctuary, it’s like letting a wolf into the fold. The study reveals that spike protein accumulates in the skull’s bone marrow, then creeps into the meninges—the protective layers surrounding the brain—and even penetrates the brain itself.

This persistence causes a cascade of damage. The spike protein triggers neuroinflammation, sparking an immune response that harms the brain’s delicate tissues. It’s a silent invasion, and over time, it leaves the brain more vulnerable to other injuries, like strokes and traumatic brain injuries, compounding the damage.

This isn’t the first time bone marrow has been implicated in COVID-19’s long-term effects. Other studies have shown that COVID-19 disrupts hematopoiesis—the process of blood cell formation—in the bone marrow. Research in Nature Communications and The Journal of Clinical Investigation links these disruptions to clotting disorders and lingering immune dysfunction. It seems the bone marrow isn’t just collateral damage; it’s a reservoir, a hiding spot where the virus’s ghost haunts the body long after the acute infection.

The Toll on the Brain
In this latest study, researchers found evidence of spike protein in the brain tissue of both humans and mice. In mice, even injecting the spike protein alone (without the virus) was enough to induce inflammation, neuronal stress, and anxiety-like behaviors. It exacerbated neurological damage after strokes and brain injuries, showing how

the presence of this protein primes the brain for harm.
In humans, cerebrospinal fluid from Long COVID patients revealed elevated biomarkers of neurodegeneration, including Tau and neurofilament light chain (NfL). These are the kinds of changes you’d expect to see in Alzheimer’s disease, not after a viral infection.

Proteomic analyses further detailed how spike protein alters key brain pathways, including those involved in immune activation, blood-brain barrier integrity, and even neuronal signaling. The picture emerging is one of long-term dysfunction—a brain thrown out of balance by the lingering presence of a protein that should have been cleared.

The Hope of Vaccination
There is a glimmer of hope. The study shows that vaccination helps reduce the spike protein’s burden. Mice vaccinated with an mRNA vaccine before infection had significantly lower levels of spike protein in their skull marrow, meninges, and brain compared to unvaccinated mice. The vaccinated animals also showed less inflammation and fewer signs of neurological damage.

This aligns with other studies. Research published in Nature Medicine has shown that vaccinated individuals are less likely to develop Long COVID symptoms, particularly neurological ones. By priming the immune system to recognize and clear the virus more effectively, vaccines appear to limit the lingering presence of its harmful components.

A New Frontier
What does this mean for the millions living with Long COVID? First, it’s a call to action for further research. The study highlights the need to target these reservoirs of viral protein, whether through treatments that enhance clearance or therapies that calm the inflammation they cause.

Second, it’s a reminder of the interconnectedness of the body. That a problem in the bone marrow could ripple into the brain isn’t entirely surprising—medicine has long known that bone health and brain health are linked. But COVID-19 is forcing us to rethink these relationships in ways that could reshape how we treat post-viral illnesses.

Finally, it’s a message of hope. While the damage COVID-19 causes is real and profound, the tools to fight it are within reach. Vaccination is already making a difference, and understanding the spike protein’s journey from bone to brain may lead us to even more precise interventions.

COVID-19 isn’t just a respiratory virus; it’s a systemic invader. And while we’re only beginning to understand its effects, each new discovery brings us closer to reclaiming the lives it has disrupted. The bones beneath our skin may tell the story of how this virus lingers, but they also hold clues to how we might finally defeat it.
http://cell.com/cell-host-micr…



More on this

(fair use applies)


Long COVID: SARS-CoV-2 spike protein accumulation linked to long-lasting brain effects
by Verena Schulz, Helmholtz Association of German Research Centres
November 29, 2024


long-covid-sars-cov-2.jpg

Visualization of SARS-CoV-2 viral tropism in whole mouse bodies and SARS-CoV-2 spike protein persistency in skull marrow and brain. (A–E) SARS-CoV-2-GFP aerosol infection in K18-hACE2 mice. (A) Illustration of SARS-CoV-2-GFP infection and imaging of whole mouse body. (B) 3D reconstruction of whole mouse body showing localization of virus-encoded GFP and viral spike protein. (C) Representative optical sections of the GFP and spike signal at 5 dpi. (D) Representative images of spike protein in the whole mouse body at 5 and 28 dpi. (E) Representative images in the skull marrow and brain at 5 and 28 dpi. Credit: Cell Host & Microbe (2024). DOI: 10.1016/j.chom.2024.11.007


Researchers from Helmholtz Munich and Ludwig-Maximilians-Universität (LMU) have identified a mechanism that may explain the neurological symptoms of long COVID.

The study shows that the SARS-CoV-2 spike protein remains in the brain's protective layers, the meninges, and the skull's bone marrow for up to four years after infection. This persistent presence of the spike protein could trigger chronic inflammation in affected individuals and increase the risk of neurodegenerative diseases.

The team, led by Prof. Ali Ertürk, Director at the Institute for Intelligent Biotechnologies at Helmholtz Munich, also found that mRNA COVID-19 vaccines significantly reduce the accumulation of the spike protein in the brain. However, the persistence of spike protein after infection in the skull and meninges offers a target for new therapeutic strategies.


Spike protein accumulates in the brain

A novel AI-powered imaging technique developed by Prof. Ertürk's team provides new insights into how the SARS-CoV-2 spike protein affects the brain. The method renders organs and tissue samples transparent, enabling the three-dimensional visualization of cellular structures, metabolites, and, in this case, viral proteins. Using this technology, the researchers uncovered previously undetectable distributions of spike protein in tissue samples from COVID-19 patients and mice.

The study, published in the journal Cell Host & Microbe, revealed significantly elevated concentrations of spike protein in the skull's bone marrow and meninges, even years after infection. The spike protein binds to so-called ACE2 receptors, which are particularly abundant in these regions.

"This may make these tissues especially vulnerable to the long-term accumulation of spike protein," explains Dr. Zhouyi Rong, the study's first author.

Ertürk adds, "Our data also suggest that persistent spike protein at the brain's borders may contribute to the long-term neurological effects of COVID-19 and long COVID. This includes accelerated brain aging, potentially leading to a loss of five to ten years of healthy brain function in affected individuals."


Vaccines reduce spike protein accumulation and brain inflammation

The Ertürk team discovered that the BioNTech/Pfizer mRNA COVID-19 vaccine significantly reduces the accumulation of spike protein in the brain. Other mRNA vaccines or vaccine types, such as vector- or protein-based vaccines, were not investigated.

Mice vaccinated with the mRNA vaccine showed lower levels of spike protein in both brain tissue and the skull's bone marrow compared to unvaccinated mice. However, the reduction was only around 50%, leaving residual spike protein that continues to pose a toxic risk to the brain.

"This reduction is an important step," says Prof. Ertürk. "Our results, while derived from mouse models and only partially transferable to humans, point to the need for additional therapies and interventions to fully address the long-term burdens caused by SARS-CoV-2 infections."

Furthermore, additional studies are needed to evaluate the relevance of these findings for long COVID patients.


Long COVID: A societal and medical challenge

Globally, 50 to 60 percent of the population has been infected with COVID-19, with five to ten percent experiencing long COVID. This sums up to approximately 400 million individuals who may carry significant amounts of spike protein.

"This is not just an individual health issue—it is a societal challenge," says Prof. Ertürk. "Our study shows that mRNA vaccines significantly reduce the risk of long-term neurological consequences and offer crucial protection. However, infections can still occur post-vaccination, leading to persistent spike proteins in the body.

"These can result in chronic brain inflammation and an increased risk of strokes and other brain injuries, which could have substantial implications for global public health and health care systems worldwide."


Advances in diagnosis and treatment

"Our findings open new possibilities for diagnosing and treating the long-term neurological effects of COVID-19," says Ertürk.

Unlike brain tissue, the skull's bone marrow and meninges—areas prone to spike protein accumulation—are more accessible for medical examinations. Combined with protein panels—tests designed to detect specific proteins in tissue samples—this could allow for the identification of spike proteins or inflammatory markers in blood plasma or cerebrospinal fluid.

"Such markers are critical for the early diagnosis of COVID-19-related neurological complications," Ertürk explains. "Additionally, characterizing these proteins may support the development of targeted therapies and biomarkers to better treat or even prevent neurological impairments caused by COVID-19."

Highlighting the broader impact of the study, leading Helmholtz Munich and Technical University of Munich virologist Prof. Ulrike Protzer adds, "Given the ongoing global impact of COVID-19 and the increasing focus on long-term effects, this study, which sheds light on brain invasion pathways and unexpected long-term host involvement, is timely. These critical insights are not only scientifically significant but also of great interest to society."

More information: Zhouyi Rong et al, Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19, Cell Host & Microbe (2024). DOI: 10.1016/j.chom.2024.11.007
Journal information: Cell Host & Microbe
Provided by Helmholtz Association of German Research Centres
 

Heliobas Disciple

TB Fanatic
probably deserves it's own thread- or heck, to be shouted from the rooftops as people are lined up and executed against pockmarked walls!- but the American attention span doesn't support the follow up/through, so I'll tuck it here...

Eric Daugherty
@EricLDaugh

#BREAKING: The House COVID Committee has released its final report after a 2-year investigation.

MAJOR FINDINGS:
- The NIH funded gain-of-function research at the Wuhan lab.
- The Constitution can't be suspended in times of crisis.
- COVID emerging from a lab leak is "not a conspiracy theory."
- EcoHealth and Dr. Peter Daszak should "never again" receive taxpayer funds.
- Public health officials have lost the trust of the people.
- Trump's Operation Warp Speed was a success.
- The COVID response was "rampant" with fraud, waste and abuse.
- "The prescription cannot be worse than the disease," lockdowns had horrific consequences.
View: https://twitter.com/EricLDaugh/status/1863653926203019384

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US lawmakers back Covid Chinese lab leak theory after two-year probe
AFP
Tue, December 3, 2024 at 8:31 AM UTC

US lawmakers concluded a two-year investigation Monday into the Covid-19 outbreak that killed 1.1 million Americans -- backing the theory that the virus likely leaked from a Chinese laboratory.

A 520-page report from the Republican-controlled House Select Subcommittee on the Coronavirus Pandemic looked at the federal and state-level response, as well as the pandemic's origins and vaccination efforts.

"This work will help the United States, and the world, predict the next pandemic, prepare for the next pandemic, protect ourselves from the next pandemic, and hopefully prevent the next pandemic," panel chairman Brad Wenstrup said in a letter to Congress.

US federal agencies, the World Health Organization and scientists across the planet have arrived at different conclusions about the most likely origin of Covid-19, and no consensus has emerged.

Most believe it to have spread from animals in China, but a US intelligence analysis said last year that the virus may have been genetically engineered and escaped from a virology lab in the Chinese city of Wuhan, where human cases first emerged.

The congressional panel was persuaded by the lab leak theory after meeting 25 times, conducting more than 30 transcribed interviews and reviewing more than one million pages of documents.

The investigation included two days of interviews behind closed doors with Anthony Fauci, the government scientist who became the nation's most trusted expert in the chaotic early days of the 2020 outbreak.

Fauci's clashes with former and incoming president Donald Trump over the response sparked fury on the right, and he now lives with security protection following death threats against his family.

Republicans accuse the 83-year-old immunologist of helping to set off the worst pandemic in a century by approving funding passed on to Chinese scientists they accuse of manufacturing the SARS-CoV-2 coronavirus that causes Covid-19.

Among its headline conclusions, the report said the National Institutes of Health had indeed funded contentious "gain-of-function" research -- which seeks to enhance viruses as a way of finding ways to combat them -- at the Wuhan Institute of Virology.

Fauci angrily denied covering up the origins of Covid-19 before the panel in June, arguing that it would be "molecularly impossible" for the bat viruses studied at the lab to be turned into the virus that caused the pandemic.

But the panel's report said SARS-CoV-2 "likely emerged because of a laboratory or research-related accident."


- Angry response in Beijing -

Beijing hit back at the report on Tuesday, saying it had "no credibility" and accusing the United States of using the outbreak for "political manipulation".

"The authoritative scientific conclusion drawn by the China-WHO joint expert team... is that a laboratory leak is extremely unlikely," foreign ministry spokesperson Lin Jian told a regular news conference.

"In the absence of any substantive evidence, the so-called US report has concocted leading conclusions, slandered China (and) planted false evidence," he said.

The probe also found that lockdowns "did more harm than good" and that mask mandates were "ineffective at controlling the spread of Covid-19," contradicting other research showing that masking in public does reduce transmission rates.

Social distancing guidelines also came under criticism, although travel restrictions were deemed to have saved lives.

Investigators found that Trump's Operation Warp Speed -- the publicly-funded project to develop Covid vaccines -- was a "tremendous success" but that school closures would have an "enduring impact" on US children.
 

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House COVID-19 panel releases final report: 3 key takeaways
Joseph Choi - The Hill
Mon, December 2, 2024 at 9:01 PM UTC

The House Select Subcommittee on the Coronavirus Pandemic released its final report Monday, laying out numerous conclusions from its review of the federal pandemic response, including what the Republican-controlled panel believes to be the likely origins of the virus.

The 520-page document encompassed a wide range of issues relating to the pandemic including vaccinations, public health guidance, state-level actions and use of relief funds.

“Since February 2023, the Select Subcommittee sought to produce a full after-action report to provide a road map of how we, in Congress, the Executive, and the private sector may better prepare for and respond to future pandemics,” subcommittee Chair Brad Wenstrup (R-Ohio) said in a letter.

“Throughout this process, the Select Subcommittee sent more than 100 investigative letters, conducted 38 transcribed interviews or depositions, held 25 hearings or meetings, and reviewed more than one million pages of documents from of custodians,” he noted.

The subcommittee’s hearings were often marked by contentious back-and-forth between members and witnesses. Several interviews were held behind closed doors, including two days of interviews with Anthony Fauci, former director of the National Institute of Allergy and Infectious Diseases, earlier this year.

Wenstrup listed seven specific findings in his letter, including that the National Institutes of Health funded controversial gain-of-function research at the Wuhan Institute of Virology, Operation Warp Speed was “tremendous success” and the public school closures will have an “enduring impact” on American children.

Here are three takeaways from the report:


Lab leak theory

The report starts with the finding that the SARS-CoV-2 virus “likely emerged because of a laboratory or research related accident.”

This finding was supported by remarks from people like Robert Redfield, the former director of the Centers for Disease Control and Prevention (CDC), former Director of National Intelligence John Ratcliffe and former U.K. Prime Minister Boris Johnson, all of whom publicly stated their support for the lab leak theory.

“Based on my initial analysis of the data, I came to believe — and still believe today — that it indicates COVID-19 infections more likely were the result of an accidental lab leak than the result of a natural spillover event,” Redfield is quoted as saying.

The report also found Fauci “prompted” the 2020 study titled “The proximal origin of SARS-CoV-2,” which supported the natural origins theory, to “disprove” the lab leak theory.

When he testified before the committee in June, Fauci reiterated that he did not edit the study or help to “suppress” the lab leak theory.

Different federal agencies have drawn different conclusions about the most likely origin of the virus, but it remains a mystery.


Mitigation efforts


The report is critical of many of the mitigation measures that were employed early on in the pandemic.

It found that masks and mask mandates were “ineffective at controlling the spread of COVID-19.” Several studies, including one published this August, have found masking in public has an effect on lowering respiratory viral transmission, though this should not be the sole measure used to mitigate spread.

Further, the report concluded lockdowns caused “more harm than good” to the economy, overall health of Americans and development of children.

The 6-foot social distancing guidance was also blasted as not being “supported by science.”

“Even though it was CDC guidance and not a mandate, it was forcefully implemented by state and local governments and caused lots of strife amongst Americans,” the report states.

However, there were some measures that the subcommittee found to have had some benefit or merit.

The public-private partnerships that were made to enable widespread COVID-19 testing early on in the pandemic allowed for “readily available and accurate tests,” though COVID-19 testing was called “flawed” in the report.

Travel restrictions were also cited as having saved lives.

“With four years of hindsight, it is clear the international travel restrictions early in the pandemic delayed spread of the virus but did not prevent COVID-19 from entering the U.S.,” states the report.


EcoHealth probes

The subcommittee’s report paid particular attention to the actions of EcoHealth Alliance, the nongovernmental organization that sub-awarded NIH grants to global labs including the Wuhan Institute of Virology.

Echoing criticism from members of the subcommittee, the report found EcoHealth failed to carry out proper oversight of the experiments it provided funding for, facilitated gain-of-function research and misled the NIH on the details of its research projects.

The NIH in turn also was found to have failed in its oversight of EcoHealth.

The report found that the Justice Department had empaneled a criminal grand jury to investigate the origins of COVID-19.

“EcoHealth was subject to numerous federal investigations regarding both its potential role in the COVID-19 pandemic, but also multiple accusations surrounding violated federal grant policies. The outcomes of most of these investigations are public,” it states.

“However, the Select Subcommittee discovered that DOJ was also investigating the origins of COVID-19,” it continued. “The specific details of the investigation are unknown but, based on documents, it appears the DOJ’s investigation involves EcoHealth’s role in the COVID-19 pandemic.”

The report says the results of the DOJ’s investigation are not public as of “December 4, 2024,” when the subcommittee plans to mark up the report.
 

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The COVID inquiry report is an excellent guide to preparing for the next pandemic—health cuts put that at risk
by Michael Baker, Amanda Kvalsvig, Collin Tukuitonga and Nick Wilson, The Conversation
November 29, 2024

The rising threat of epidemics and pandemics adds urgency for the government to act on the recommendations of the long-awaited inquiry into New Zealand's COVID response.

The Royal Commission of Inquiry into COVID-19 report found New Zealand—like most other countries—was not well prepared for a pandemic of COVID's scale and duration.

To prepare for the next inevitable pandemic, the report says New Zealand must build public health capacity to increase the range of response options and tools available to decision makers.

The big question is when and how the government will implement these recommendations, particularly in the context of job cuts and downsizing of public health capacity.

Te Whatu Ora/Health NZ is set to cut 1,500 more jobs (on top of more than 500 voluntary redundancies), including positions in the national public health service and its digital and data teams.

These capabilities are critical for any future pandemic response, so there is a strong argument to halt the cuts while New Zealand is implementing the recommendations of the COVID inquiry.


Strategy is key


The report concludes that New Zealand's adoption of an elimination strategy was highly successful, but had wide-ranging impacts on all aspects of life.

The strategy required early use of border controls, lockdowns and other restrictions, which helped prevent widespread infection until most of the population was vaccinated. This response gave New Zealand one of the lowest COVID mortality rates globally.

The report also found that as the pandemic progressed into late 2021, the negative impacts increased. Controlling the pandemic was focused on mandates, including restrictions on public gatherings, quarantine and isolation, contact tracing, masking and vaccination requirements.

The effects included declining trust in government within some communities and loss of social cohesion. Vaccine hesitancy emerged as a growing challenge to the vaccine rollout, fed by exposure to misinformation and disinformation.

The prolonged pandemic and lack of a clear exit strategy from elimination added to the difficulties, according to the commission's report.


A road map for pandemic planning

The report identifies how COVID expanded international understanding of pandemic pathogens, which require a different kind of response from most other emergencies because of their scale and duration.

This challenge benefits from clear strategic leadership coupled with strong social cohesion and trust. Pandemics require anticipatory governance, and long-term planning and investment. This conclusion is consistent with those of the first published module from the UK's COVID inquiry.

The report's 39 recommendations provide a welcome and needed road map for future pandemic planning. It calls for a central agency function to coordinate all-of-government preparation and response planning for pandemics and other national threats, supported by strengthened scenario planning and modeling.

This planning would integrate sector-specific plans. The Ministry of Health would be responsible for the most substantial sector planning linked with the all-of-government plan.

This greatly expanded pandemic plan would set out a range of public health strategies (such as elimination, suppression and mitigation) and associated public health and social measures, as well as guidance on how they might be deployed.

The plan would cover quarantine and isolation measures, contact tracing, testing, vaccination, infection prevention and control, and information and data capability to deliver a pandemic response.

The recommendations also include improving the way public sector agencies work alongside iwi during a pandemic to support the Crown in its relationship with Maori under te Tiriti o Waitangi.

However, the report doesn't say much about reducing the long-term effects of COVID infection, notably the large burden of long COVID. The pandemic is still continuing and ongoing vaccination and efforts to reduce infections remain important. This is an area where Australia's COVID inquiry report had a stronger focus.


Challenges of implementation

The report's final recommendation is critical. It calls for assigning a government minister to lead the implementation process, and for six-monthly reporting on progress to be made publicly available. This is where we need a clear response from the coalition government.

Implementation should begin immediately, the report proposes. However, it's possible action could be delayed until the first half of 2026 while we wait for an additional phase 2 of the inquiry. This will review aspects of our COVID-19 response in greater detail.

But the major logistical barrier to implementation is the downsizing of key government agencies needed to do this work. The situation in New Zealand is in stark contrast with Australia where the release of their report coincided with an announcement of a A$251 million investment in establishing a national center for disease control.

Building New Zealand's pandemic capabilities would also help control the current pertussis epidemic and prevent a likely national measles epidemic.

Meanwhile, the risk of future pandemics is increasing. Modeling suggests an 18%–26% chance of another COVID-magnitude pandemic within the next decade.

There is a long and growing list of infectious agents with pandemic potential. High on that list is influenza, with the risk from bird flu (influenza H5N1) increasing as it adapts to new mammalian hosts like cattle, and now humans in North America.

We have the plan, now all we need is a rapid government response, proactive leadership and anticipatory decision-making to give New Zealand the pandemic preparedness it urgently needs.
 

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Andrew Cuomo committed ‘medical malpractice’ during deadly COVID crisis, House report finds
By Carl Campanile
Published Dec. 2, 2024, 7:31 p.m. ET

Ex-Gov. Andrew Cuomo committed “medical malpractice” and publicly undercounted the total number of COVID-related nursing home deaths in New York during the worst period of the killer pandemic, a damning final investigative report released by a key House panel found.

The report from the Republican-led House Select Subcommittee on the Coronavirus Pandemic, released Monday, also concluded that Cuomo “likely gave false statements” about his role in pandemic decision-making.

That includes him actually being “directly involved” in the infamous March 2020 edict directing nursing homes to admit recovering COVID-19 patients — and downplaying pandemic-related deaths of residents in a July 2020 report, the House panel found.

In another finding, the report concluded that Cuomo “acted in a manner consistent with an attempt to inappropriately influence the testimony of a witness and obstruct the Select Subcommittee’s investigation,” referring to his contacts with former adviser James Malatras.

The House had previously released documents laying out the allegations about Cuomo and his administration’s actions — but the more-than 500-page final report paints a devastating picture of the three-term Democratic governor’s decisions that the subcommittee claims undermined public health.

Cuomo — who is weighing a political comeback run for mayor after resigning as governor in 2021 amid sexual misconduct accusations he denied — ripped the report as a partisan GOP witch hunt.

“This is the same weak gruel the MAGA Republicans on this committee have been peddling for months if not years,” said Cuomo spokesman Richard Azzopardi.

But Rep. Brad Wenstrup, an Ohio Republican who chaired the panel, said in the opening letter of the report that there was bipartisan consensus on numerous topics including “that former New York Governor Andrew Cuomo participated in medical malpractice and publicly covered up the total number of nursing home fatalities in New York.”

A more than 40-page section of the report focuses solely on Cuomo and the state government’s response to the pandemic. Cuomo’s name appears in the report 203 times.

Among the findings alleged in the report are that:
  • The Cuomo administration’s March 25, 2020 directive to admit or readmit recovering COVID-19 patients into nursing homes was “medical malpractice,” “antithetical to known science” and inconsistent with federal guidance — and the Executive Chamber “attempted to cover it up.”
  • Contrary to his denials during House testimony, Cuomo and his top aides and advisers were “directly Involved” in and approved the infamous directive, which was later rescinded following public outcry.
  • Cuomo administration officials testified that the governor ordered the controversial July 6, 2020 state Department of Health report — which was criticized for lowballing nursing home resident deaths from COVID — to combat criticism of the March 25 edict.
  • Cuomo was directly involved in editing the July report and directing people outside the government — such as Northwell Health CEO Michael Dowling and Greater NY Hospital CEO Kenneth Raske to review it. In a memo shortly before the report’s release and obtained by the House panel, Dowling offered to help “rewrite” it.
  • Cuomo’s executive chamber decided to remove “out-of-facility” fatalities — such as nursing home residents who died from COVID after falling ill and being transferred to hospitals — from the July report, thus dramatically reducing the total death toll.

The panel also concluded that “Mr. Andrew Cuomo Likely Gave False Statements to the Select Subcommittee in Violation of 18 U.S.C” — a federal crime that if proven could result in a sentence of five years in prison.

The committee in October said it had referred Cuomo’s “criminally false statements” to the US Department of Justice for potential prosecution.

Cuomo’s rep, Azzopardi, claimed the House was out to get “perceived political enemies.”

“From the very beginning this has been an abuse of power and a waste of taxpayer money aimed at punishing perceived political enemies – like Dr. [Anthony] Fauci [then Director of the National Institute of Infectious Diseases], Governor Cuomo and ‘the deep state’ – that does nothing to make us more prepared for the next pandemic,” he said.

He claimed federal data showed that New York ranked 39th in terms of per capita nursing home deaths in 2020.

“The DOJ -three times – the Manhattan DA and others looked at the nursing home issue and found no wrongdoing, while the meritless civil lawsuit launched by the very same people who have been working arm and arm with this committee was tossed out of court,” Azzopardi added.

Families of loved ones who were nursing home residents and died from COVID said Cuomo was finally being held to account.

“Cuomo has been lying about following the Trump CDC guidelines for years,” said Peter Arbeeny, whose father, Norman, died from the virus after being released from a Brooklyn nursing home.

“If the Cuomo administration would have followed the Trump [administration] CDC guidelines and also used the the USS Comfort ship and Javits Center [for more patients], thousands of lives would have been saved.”
 

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House Oversight Report Supports Chinese Lab-Leak Theory for COVID-19 Origin
The report stated that several researchers at the Wuhan Institute of Virology fell sick with a COVID-19-like virus months before the first case emerged.

By Aldgra Fredly
12/3/2024

A Republican-led oversight subcommittee has concluded that the COVID-19 virus likely originated from a laboratory in Wuhan, China, following a two-year investigation into the pandemic.

The House Oversight Select Subcommittee on the Coronavirus Pandemic released a 520-page report on Dec. 2, detailing the findings of the subcommittee’s investigation.

The report found that the U.S. National Institutes of Health funded gain-of-function research at the Wuhan Institute of Virology (WIV), and that EcoHealth Alliance Inc. used U.S. taxpayer dollars to facilitate this research at the lab.

It also found that the Chinese communist regime, agencies within the U.S. government, and some members of the international scientific community sought to cover up facts concerning the origins of the pandemic.

The committee said that COVID-19 possesses biological characteristics not found in nature and that data indicates that all COVID-19 cases stemmed from a single introduction into humans, unlike previous pandemics, where there were more spillover events.

“By nearly all measures of science, if there was evidence of a natural origin it would have already surfaced,” the oversight subcommittee said in a statement.

The report said that the Wuhan Institute of Virology has a history of conducting “gain-of-function” research under low biosafety precautions.

Several researchers from the Wuhan Institute of Virology fell sick with a COVID-like virus months before the first case of the outbreak was allegedly detected at a wet market, according to the report.

The report said that in January 2021, the U.S. State Department published an unclassified fact sheet that stated: “The U.S. government has reason to believe that several researchers inside the WIV became sick in autumn 2019, before the first identified case of the outbreak, with symptoms consistent with both COVID-19 and common seasonal illness.”

Citing the fact sheet, the report stated that the Wuhan Institute of Virology “has a published record of conducting ‘gain-of-function’ research to engineer chimeric viruses.”

The report said the June 2023 ODNI assessment supported this conclusion and went further, stating, “Scientists at the WIV have created chimeras, or combinations of SARS-like coronaviruses through genetic engineering, attempted to clone other unrelated viruses, and used reverse genetic cloning techniques on SARS-like coronaviruses.” The June 2023 ODNI Assessment said that some of the “WIV’s genetic engineering projects on coronaviruses involved techniques that could make it difficult to detect intentional changes.”

Among those interviewed during the panel’s investigation was Anthony Fauci, former director of the National Institute of Allergy and Infectious Diseases (NIAID), who stepped down from his role in December 2022.

The report stated that Fauci had “prompted” a research study titled “The Proximal Origin of SARS-CoV-2”—which dismissed the idea that the virus was laboratory constructed—to “disprove” the lab leak theory.

Fauci testified at a June hearing that he did not suppress the lab leak theory and did not view it as inherently a conspiracy theory but said that “some distortions on that particular subject are,” according to the report.

“Although Dr. Fauci believed the lab-leak theory to be a conspiracy theory at the start of the pandemic, it now appears that his position is that he does have an open mind about the origin of the virus—so long as it does not implicate EcoHealth Alliance, and by extension himself and NIAID,” it stated, citing Fauci’s memoir published just weeks after the hearing. “Understandably, as he signed off on the EcoHealth Alliance grant.”

In a May 2021 Senate hearing, Fauci said his agency did not provide funds for “gain of function” research into coronaviruses at the Wuhan Institute of Virology.

“The NIH has not ever and does not now fund gain-of-function research in the Wuhan Institute of Virology,” Fauci told the hearing.

The report also stated that Taiwan notified the World Health Organization (WHO) on Dec. 31, 2019, about “atypical pneumonia cases” reported in Wuhan and asked the agency to investigate, but the WHO ignored the warnings.

The WHO response to the COVID-19 pandemic was “an abject failure because it caved to pressure from the Chinese Communist Party and placed China’s political interests ahead of its international duties,” the subcommittee said.

In a statement accompanying the report, Rep. Brad Wenstrup (R-Ohio), chairman of the committee, said, “The COVID-19 pandemic highlighted a distrust in leadership. Trust is earned. Accountability, transparency, honesty, and integrity will regain this trust.”

A study published in the journal Risk Analysis on March 15 found a high probability that the COVID-19 virus had an unnatural origin. Although the study did not prove the origin of the COVID-19 virus, its authors said that “the possibility of a laboratory origin cannot be easily dismissed.”

The Epoch Times reached out to Anthony Fauci, NIAID, EcoHealth Alliance Inc., and the WHO for comment but did not receive a response by publication time.
 

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Democrats push back on Republican COVID-19 report
Joseph Choi - The Hill
Tue, December 3, 2024 at 8:13 PM UTC

House Democrats on the Select Subcommittee on the Coronavirus Pandemic on Tuesday released their own report responding to the Republican-led panel’s final report, deeming the subcommittee to have “failed” in its endeavor to uncover the origins of COVID-19 and instead having “fueled extreme narratives.”

The select subcommittee on Monday released its final report, in which they concluded the COVID-19 virus likely originated from a lab leak, a theory that Republicans on the panel vehemently defended throughout their investigation.

Among the Republicans’ other findings were oft-repeated accusations that Anthony Fauci, former director of the National Institute of Allergy and Infectious Diseases (NIAID), sought to suppress the lab leak theory and that the National Institutes of Health had funded gain-of-function research that may have led to a lab leak.

“Select Subcommittee Republicans’ final report reflects two years wasted on political stunts instead of preventing and preparing for the next pandemic,” a spokesperson for Democrats on the subcommittee said of the report on Monday.

“Instead of coming together with Democrats to get ahead of future viruses or fortify America’s public health infrastructure and workforce, Select Subcommittee Republicans prioritized extreme probes that vilified our nation’s scientists and public health officials in an effort to whitewash former President Trump’s disastrous COVID-19 response,” they added.

The Democrats’ report pushed back on and dissected several of these claims, saying the GOP members had failed to “shed meaningful light on the question of the COVID-19 pandemic’s origins.” It blasted the criticisms against Fauci as ranging from “baseless to frivolous.”

“Today, a zoonotic origin and lab accident are both plausible, as is a ‘hybrid’ scenario reflecting a mixture of the two,” the report stated. “It was repeatedly explained to the Select Subcommittee that all prior epidemics and pandemics, as well as almost all prior outbreaks, have zoonotic origins. At the same time, a lab origin for SARS-CoV-2 also remains plausible.”

The report did show bipartisan agreement when it came to instances of likely misconduct. As was also noted in the Republican report on Monday, Democrats cited David Morens, senior advisor at NIAID, as having conducted himself in a way “unbecoming” of someone in his position.

Democrats were also in agreement that EcoHealth Alliance, a nongovernment organization that sub-awarded federal grants for infectious disease research prior to the pandemic, had not adequately monitored its grant recipients’ work, including the research done at the Wuhan Institute of Virology.

“During the 118th Congress, Select Subcommittee Republicans have failed to prove their spurious allegations,” the Democrats concluded in their report. “They failed to shed additional light on the origins of SARS-CoV-2 — and instead advanced baseless attacks on Dr. Fauci and other public health professionals and further eroded public trust in our nation’s scientists and public health officials.”
 

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New antibody discovery offers hope against evolving SARS-CoV-2 variants
by Kumamoto University
December 2, 2024

Researchers at Kumamoto University have discovered a monoclonal antibody capable of neutralizing a wide range of SARS-CoV-2 variants, including the elusive omicron subvariants. This antibody, named K4-66, was isolated from a delta breakthrough infection case.

The findings, published in the journal eBioMedicine, highlight K4-66's exceptional ability to target multiple SARS-CoV-2 variants, including recent omicron strains such as EG.5.1, XBB.1.5, and JN.1.

The research team, led by Professor Shuzo Matsushita from the Joint Research Center for Human Retrovirus Infection (JRCHRI), Kumamoto University, found that K4-66 uses a gene known as IGHV3-53/3-66, which allows it to adapt to the virus's frequent mutations. This gene contributes to the development of "public antibodies," a type of antibody often induced in vaccinated or infected individuals.

While many public antibodies lose efficacy against heavily mutated variants, K4-66 exhibits a rare ability to neutralize them, even reducing viral loads in the lungs of hamster models infected with omicron XBB.1.5.

Structural analyses of K4-66 revealed that its broad-spectrum effectiveness lies in its ability to form electrostatic interactions with the receptor-binding domain (RBD) of the spike protein, a crucial region for the virus to infect human cells.

This discovery is particularly significant as the constant evolution of SARS-CoV-2 has created variants that evade immunity from current vaccines and therapeutic antibodies. Omicron subvariants, in particular, have proven highly resistant, complicating global efforts to control the pandemic.

K4-66's ability to neutralize diverse variants offers hope for the development of new vaccines and therapies that remain effective despite the virus's rapid evolution.

The implications of this research extend beyond immediate applications. The study suggests that enhancing the maturation of public antibodies like K4-66 through targeted vaccine strategies could lead to more robust and durable immune defenses. Such advancements have the potential to prevent future outbreaks and mitigate the risks posed by emerging variants.

This breakthrough was achieved through collaboration with institutions across Japan, including the University of Tokyo and Kyoto University. Professor Matsushita emphasized the importance of this discovery, noting its potential to guide next-generation vaccine development.

More information: Takeo Kuwata et al, Induction of IGHV3-53 public antibodies with broadly neutralising activity against SARS-CoV-2 including Omicron subvariants in a Delta breakthrough infection case, eBioMedicine (2024). DOI: 10.1016/j.ebiom.2024.105439
Journal information: EBioMedicine
Provided by Kumamoto University
 

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BREAKING - New Study Urges Immediate Halt to COVID-19 mRNA Injections Over Alarming Levels of DNA Contamination
Researchers find DNA contamination in COVID-19 mRNA injections exceeding regulatory limits by over 300%, confirming findings from earlier studies.

Nicolas Hulscher, MPH
Dec 03, 2024

Calls for an immediate global moratorium on COVID-19 mRNA injections continue to intensify. Today, Kammerer et al published the study titled, BioNTech RNA-Based COVID-19 Injections Contain Large Amounts Of Residual DNA Including An SV40 Promoter/Enhancer Sequence, in the journal Science, Public Health Policy and the Law:



Here’s a brief summary of their findings:
Background: BNT162b2 RNA-based COVID-19 injections are specified to transfect human cells to efficiently produce spike proteins for an immune response.
Methods: We analyzed four German BNT162b2 lots applying HEK293 cell culture, immunohistochemistry, ELISA, PCR, and mass spectrometry.
Results: We demonstrate successful transfection of nucleoside-modified mRNA (modRNA) biologicals into HEK293 cells and show robust levels of spike proteins over several days of cell culture. Secretion into cell supernatants occurred predominantly via extracellular vesicles enriched for exosome markers. We further analyzed RNA and DNA contents of these vials and identified large amounts of DNA after RNase A digestion in all lots with concentrations ranging from 32.7 ng to 43.4 ng per clinical dose. This far exceeds the maximal acceptable concentration of 10 ng per clinical dose that has been set by international regulatory authorities. Gene analyses with selected PCR primer pairs proved that residual DNA represents not only fragments of the DNA matrices coding for the spike gene, but of all genes from the plasmid including the SV40 promoter/enhancer and the antibiotic resistance gene.
Conclusion: Our results raise grave concerns regarding the safety of the BNT162b2 vaccine and call for an immediate halt of all RNA biologicals unless these concerns can be dispelled.

This study corroborates the work of many others, including but not limited to: Kevin McKernan, Phillip Buckhaults, Brigitte König, David Speicher, and Didier Raoult:



All of this evidence supports Florida Surgeon General Joe Ladapo’s call to halt COVID-19 mRNA injections due to DNA contamination:



Calls for an immediate moratorium on COVID-19 mRNA injections will continue to intensify, ultimately leading to the removal of these dangerous products from the market.

Nicolas Hulscher, MPH

Epidemiologist and Foundation Administrator, McCullough Foundation

www.mcculloughfnd.org
 

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DNA Contamination in Pfizer COVID Vaccines Up to Four Times Legal Limits, Study Finds
The peer-reviewed study published this week also found SV40 DNA contaminants in the vaccines, and the researchers also determined that the spike proteins produced by the vaccines persist in the body longer than claimed.

by Michael Nevradakis, Ph.D.
December 4, 2024

Researchers found DNA in Pfizer’s COVID-19 vaccines at levels three-to-four times higher than regulatory limits, according to a new “bombshell” study.

“This far exceeds the maximal acceptable concentration of 10 ng [nanograms] per clinical dose that has been set by international regulatory authorities,” the authors wrote.

The peer-reviewed study, published this week in the journal Science, Public Health Policy and the Law, also found simian virus 40 (SV40) DNA contaminants in the vaccines. And the researchers determined that the spike proteins produced by the vaccines persist in the body longer than claimed.

The findings led the authors to call for “an immediate halt of all RNA biologicals.”

Karl Jablonowski, Ph.D., senior research scientist at Children’s Health Defense (CHD), told The Defender that DNA contamination may contribute to the increase in autoimmune diseases among the vaccinated. “The immune system operates on very sensitive detections to initiate responses,” he said.

“DNA suddenly deposited into your bloodstream could kickstart the interferon response,” Jablonowski said. “The interferon response, when there’s nothing to find but ‘self,’ could be the springboard for autoimmune disease.”

The study also showed that the spike proteins produced after vaccination persist in the body for at least seven days following vaccination instead of the shorter period Pfizer-BioNTech previously claimed. The spike proteins are also prone to shedding.

These results “raise grave concerns” about mRNA vaccines, the study concluded.

Kevin McKernan, founder of Medicinal Genomics, is the first scientist who identified the presence of SV40 in the mRNA vaccines. He called the new study “a tour de force on the DNA contamination topic.” McKernan wrote about the study on Substack, and said in an X post that the study’s authors “knocked it out of the park.”

Immunologist and biochemist Jessica Rose, Ph.D., agreed. “This paper is the paper of the century. The paper is not only a work of art in terms of the study layout. It is very well-written and settles ongoing ‘issues’ pertaining to allegations made by regulatory bodies that the DNA contamination issue is misinformation,” Rose said.

Dr. Angus Dalgleish, professor of oncology at St George’s, University of London, told The Defender the study “diligently used techniques proving that these samples contain large amounts of DNA” and that “these samples easily enter and express in a known kidney cell line used as a standard to examine these phenomena.”

The new study follows the recent publication of a peer-reviewed paper in the Journal of American Physicians and Surgeons, identifying serious safety concerns in the mRNA COVID-19 shots. The authors of that study called “at minimum” a moratorium on the shots.

The papers join a growing list of scientists and organizations calling for a ban on COVID-19 mRNA vaccines. They include Florida’s surgeon general, the Association of American Physicians and Surgeons, Doctors for COVID Ethics, Americans for Health Freedom and the World Council for Health.

In October, Idaho’s health board voted to stop offering COVID-19 vaccines at its 30 clinics because of safety concerns. Also that month, the Slovak government issued a report proposing a ban on “dangerous” mRNA vaccines.

The new study comes amid the launch of an online library, the SARS-CoV2 Spike Protein Pathogenicity Research Collection, a database of over 250 peer-reviewed studies detailing the risks posed by spike proteins.

Dalgleish said the latest study “completely confirms” the Journal of American Physicians and Surgeons paper. “The two together should be enough legal evidence to call for the immediate ban of mRNA vaccines.”


COVID mRNA shots ‘have a dangerous mechanism of action’

In an interview with The Defender, Klaus Steger, M.D., Ph.D., professor of molecular andrology at the University of Giessen in Germany and corresponding author of the new study, analyzed the study’s findings and their significance.

The study found the presence of “residual DNA in modRNA [modified mRNA]-based Pfizer-BioNTech genetic vaccines, the concentration of which far exceeds the limits set by the international regulatory agencies. Importantly, a significant amount of this residual DNA is packaged within lipid nanoparticles,” Steger said.

According to Steger, this is significant because the lipid nanoparticles can deliver the DNA throughout the human body. He said:

“The first problem is that the existing limits set by the international regulatory agencies apply to ‘naked DNA,’ like the residual DNA in drugs produced in genetically modified bacteria, e.g., insulin or some antibiotics.

“However, DNA in the modRNA-based genetic vaccines, together with the modified mRNA, is packaged within lipid nanoparticles and thus is delivered unnoticed by our immune system into our cells.”

McKernan said the study shows that DNA is “getting into cells and not degrading.” According to Steger, “Due to the … safety risks of DNA packaged within lipid nanoparticles, the limit value for DNA must undoubtedly be zero.”

Another key finding according to Steger is the identification of two copies of an “SV40 promoter/enhancer sequence.” Steger said this SV40 sequence can “act in human cells … to encourage nuclear transport of plasmid DNA,” raising “safety concerns of unintended genomic integration of residual DNA” from the plasmid.

The presence of SV40 “increases the risk for the plasmid-DNA of being transported into the cell nucleus and probably integrated into the genome,” Steger said.

Jablonowski said SV40 penetrates the barriers of human cells, transferring foreign DNA directly into the nuclei, “violating that which ought to remain inviolable.”

Steger said the results also show “robust spike protein production by cultured cells.” The produced spike proteins “did not stay parked on the cell membrane” at the injection site, but were “packaged into exosomes.” According to Steger, “This means that the produced spike protein may be exported all over the body.”

Cardiologist Dr. Peter McCullough told The Defender the “mRNA COVID-19 vaccines have a dangerous mechanism of action. They contain the genetic code for the potentially lethal SARS-CoV-2 spike protein. Once injected into the body, there is no way to control their biodistribution, duration or quantity of spike protein produced.”

“As a result, some victims must have maldistribution, over-produce spike protein, or have susceptibilities to its cellular and tissue-damaging properties,” McCullough said.

Christof Plothe, D.O., a member of the World Council for Health steering committee, told The Defender the study showed that the presence of spike proteins lasted more than seven days, contradicting “earlier models that suggested the spike proteins would remain anchored at the injection site and dissipate within 48 hours.”

Plothe said the study also demonstrated that shedding of the spike proteins is also possible. “The research showed that the spike proteins are not merely stuck to the cell membrane — instead, they are packaged into exosomes, which are tiny vesicles that can be released from cells and potentially travel throughout the body.”

“This finding has major implications for the concept of ‘shedding,’ suggesting that if exosomes contain plasmid DNA, it could be transmissible and might even have the ability to replicate, posing additional risks,” Plothe said.

According to Steger, these mechanisms and risks are not limited to the Pfizer-BioNTech COVID-19 shots but are true of all mRNA vaccines. He said:

“The problems pointed out by our study represent general problems typical for this new type of modRNA genetic vaccine, their production process and their mode of action.

“This means that independent of the type of future plasmids applied in the production process, modRNA genetic vaccines will act in an identical way — namely, they genetically transfect our body cells and convert them into production facilities for a foreign viral antigen without any control mechanisms on unwanted negative side effects.”

Steger said this poses significant dangers for human health — including risks that could be passed on to offspring.

“This not only bears the undeniable risk of causing an autoimmune disease, but with regard to the residual plasmid DNA, raises the safety risk of DNA delivery to the cell nucleus and insertion into the genetic material — and in a worst-case scenario, even to the offspring,” Steger said.

Pfizer has previously acknowledged the presence of SV40 in its COVID-19 shots “but has downplayed any associated side effects,” Plothe said. Jablonowski noted that Pfizer and BioNTech have the resources to conduct such a study — but haven’t.

“This paper is within Pfizer-BioNTech’s capabilities,” Jablonowski said. “Yet, three researchers pieced together a highly technical effort with no external funding, showing that Pfizer-BioNTech endangered everyone injected with their product.”

“This paper explains why we have witnessed record injuries, disabilities and death after COVID-19 vaccination,” McCullough said. “There are calls from all over the world to remove these products from human use. The only way to stop further harm is to shut down the COVID-19 vaccination campaign.”

Joseph Sansone, Ph.D., author of the “Ban the Jab” resolution adopted by 10 Florida counties, told The Defender he supports the authors’ call for a moratorium. He said the study “raises serious concerns about genetic changes and the potential to predispose future generations to cancer and other diseases.”


New database of spike protein studies contributes to calls to ban mRNA shots

Steger said his paper was the target of scientific censorship. His team previously submitted the study “to two other journals, both with their main focus on vaccines.” However, both journals “returned the manuscript immediately” without reviewing it.

That led to the development of the SARS-CoV2 Spike Protein Pathogenicity Research Collection — a database of “over 250 peer-reviewed scientific studies confirming that the spike protein is highly pathogenic on its own.”

Erik Sass, a research assistant for the project, told The Defender, “This collection of research demonstrates that the SARS-CoV2 spike protein can inflict harm on the human body through a remarkably wide range of mechanisms.”

The database “also advances our understanding of the causes and possible treatments for ‘long COVID’ and vaccine injuries resulting from uncontrolled production of the spike protein throughout the body,” Sass said.

Sass said the database contains studies “published in reputable scientific journals following peer review,” but that many “formerly respected scientific publications have deviated from the high standard of intellectual integrity that made them authoritative.”

According to Sass, the project was inspired by the publication of “Toxic Shot: Facing the Dangers of the COVID ‘Vaccines’” in June — particularly its chapter on spike proteins. Sass was one of the researchers who contributed to that chapter.

“As more and more research emerged, we decided to continue adding to the collection to turn it into a standalone resource for general reference,” Sass said.

Brian Hooker, Ph.D., chief scientific officer for CHD, called the new database “a great resource for both practitioners looking for treatment options as well as scientists studying the very obvious toxicity of the COVID-19 vaccine and SARS-CoV-2 spike protein.”

“We need directly accessible information for what the future holds for addressing the myriad chronic illnesses caused by spike protein exposure,” Hooker said. For Dalgleish, the database “constitutes overwhelming evidence” that the spike protein “is highly dangerous and its use must be halted immediately.”

“Studies like ours are now being published at ever shorter intervals and occasionally find their way into the mainstream media,” Steger said. “It is only a matter of time before the house of cards of ‘safe and effective vaccinations’ will collapse.”
 

Heliobas Disciple

TB Fanatic
(fair use applies)



A Mystery “Flu-Like” Disease With A Very High Death Rate Is Suddenly Spreading Like Wildfire In Africa
Michael Snyder
December 4, 2024

A mysterious disease that produces “flu-like” symptoms and that is killing a very high percentage of those that it infects has suddenly appeared in the Democratic Republic of Congo, and scientists have no idea what it is. So far, this mystery disease does not appear to be related to H5N1, monkeypox, Ebola, the Marburg virus or any of the other deadly bugs that are currently spreading around the globe. Perhaps after more testing is done, scientists will discover that there is a very simple explanation after all. And let us hope that this new outbreak turns out to be fairly insignificant in the grand scheme of things. But in Matthew 24, Jesus did warn us that there would be multiple “pestilences” in the days just before His return. So when a new disease suddenly appears and starts killing lots of people, it is worth keeping an eye on.

The epicenter for this outbreak is right along the Democratic Republic of Congo’s border with Angola, and we are being told that dozens of victims are already dead…
AN UNKNOWN “flu-like” disease targeting women and children has killed 143 within two weeks.
Those infected in Congo have suffered from symptoms including high fever and severe headaches with the World Health Organisation launching an urgent probe.
Deaths are being recorded in Kwango province, situated in the Southwest of the Democratic Republic of the Congo (DRC) and on its border with Angola.
If this mystery disease is “targeting women and children”, does that mean that adult men are not being affected?

Hopefully we can get some clarification on that.

It is being reported that a total of 376 people have gotten sick so far, but it is not clear how they were able to determine that everyone has the same thing if they are not able to identify the disease…

The country’s health ministry also warned people to wash their hands regularly with soap and water and not to touch dead bodies.
A total of 376 people have been sickened in the outbreak, that has hit Kwango province in the southwest of the Democratic Republic of the Congo (DRC).
It is very early in this outbreak, and so the numbers that we are being given are very fluid.

But if there really are 143 total dead out of 376 total victims, that is a very, very high death rate.

Many of the symptoms that victims are experiencing are exactly what you would expect if you caught the normal flu

Patients are mostly children over 15 years old, officials say, and are suffering from a flu-like illness with symptoms including a fever, headache, nasal discharge, cough, difficulty breathing and anemia — or a lack of healthy red blood cells.
I don’t see anything there that would set it apart from normal winter illnesses.

And that also makes it potentially extremely dangerous.

We shall see how this plays out.

For now, one local leader is warning that “the number of infected people is increasing” and that people are literally dropping dead in their own homes…

Civil society leader Cephorien Manzanza said that the situation on the ground is extremely worrying as the number of infected people is increasing. “Panzi is a rural health zone, so there is a problem with the supply of medicines,” Manzanza said.
Due to a lack of medical facilities and a dilapidated health infrastructure, infected people are forced to die in their homes.
A local epidemiologist said women and children were the most seriously affected by the disease.
This sounds very serious.

But let’s not jump to any conclusions quite yet.

Tests are being conducted on this new disease, and authorities are promising to release results as soon as they can

The Ministry added in its update: ‘Laboratory test results will be communicated as soon as they are available, and regular updates will be shared with the population and partners.
‘Pending the conclusions of the ongoing investigations, the Ministry calls on the population to remain calm, vigilant and to strictly respect the… preventive measures.’
Of course this new outbreak comes at a time when the Democratic Republic of Congo is already struggling to contain an unprecedented monkeypox outbreak
Meanwhile, the DRC is also contending with a major mpox outbreak, which was declared a public health emergency of international concern in August. In early November, the total number of suspected mpox cases across the continent of Africa topped 50,000, with the DRC bearing a high percentage of those cases.
Scientists are telling us that this new strain of the monkeypox spreads much more easily than the strain that caused so many problems around the globe in 2022, and it also has a much higher death rate.

So I am keeping a very close eye on that too.

Meanwhile, the Marburg virus has gotten loose in Rwanda

Marburg, also termed as the ‘Bleeding Eye’s virus due to one of its symptoms (bleeding of the eye), has killed 15 people in Rwanda and has left hundreds of them infected, reports The Mirror.
The World Health Organisation (WHO) identifies the disease to be severe, often resulting in fatal illness in humans. “The average MVD case fatality rate is around 50%. Case fatality rates have varied from 24% to 88% in past outbreaks,” the WHO says in a report which was updated in October 2024.
After what we went through earlier in this decade, I know that there are lots of people out there that don’t want to hear this sort of news.

But if we really are living in the end times, major pestilences will be a major theme. Jesus specifically warned us about this in Matthew 24. He didn’t give us this warning so that we would be afraid. He gave us this warning so that we would not be afraid.

If you understand what is coming, you can get prepared for it.

Sadly, most of the population is not interested in such warnings, and so when the next great global health crisis reaches our shores they will be completely blind-sided by it.
 

Heliobas Disciple

TB Fanatic
(fair use applies)


How influenza responds when we start vaccinating against it
Radagast

December 5, 2024

I’ve explained through a few posts now, how SARS-COV-2 responds to the population’s antibodies, by adding sugar molecules (glycans) to regions targeted by the antibodies. This is how viruses tend to evolve to resist antibodies over time, regular influenza (H3N2) has been slowly doing this in response to mass vaccination of elderly and HIV gradually does it within a person over a period of years.

There are studies that look at what happens when you add glycans to a virus. Generally the innate immune system gets a bit better at handling the virus, whereas the antibodies become useless. But it’s hard to completely simulate what happens in the lab, not in the least of reasons that in the wild, you’re dealing with a quasispecies swarm. This is what we call it, when many different mutants, each with slightly different traits, circulate together and jump from one person to another together.

This has the effect of increasing its ability to sicken people, through various methods. One version may be better at infecting certain tissues and organs than the other. One version may optimally replicate at 38 degrees, another may optimally replicate at 39 degrees. The fever induced by the prior then aids the latter in replicating.

That’s what goes on with SARS2. About half the detected samples evade antibodies on the N1 loop by putting a glycan at position 22, the other half evade antibodies by putting a glycan at position 30, by deleting S:31. They both replicate optimally at slightly different temperatures, so having them circulate together probably increases virulence.

The SARS2 swarm of different variants grows increasingly virulent over time as it diversifies, but sometimes it has to start from scratch again. When Omicron emerged, it started from scratch again, losing its genetic diversity. This played a role in causing the virulence to suddenly drop. About a year ago, antibodies emerged against the N1 loop in the NTD, that were very difficult to overcome. This again forced the swarm to start from scratch, with BA.2.86, which spread across the globe once it added two further mutations to turn into JN.1.

As time goes on, it becomes harder for the immune system to find some region to target with antibodies that will work on the entire swarm. It happened twice so far, but there’s no guarantee the whole swarm will have to start from scratch again at some point in the future. The first time such a global reset happened, it also proceeded much more rapidly than the second time.

So when it comes to understanding how vaccination will impact what’s going to happen, I think it’s useful to look at the experiment of vaccinating chickens against H5N1 again. We know what the virologists fear, by what they decide to experiment with. Whether it is wise for them to engage in their experiments, is a different question.

As an example, have a look at this experiment, where they decided to apply what we may now refer to as the van den Bosschean horror scenario to H5N1: They edited the virus, to put glycans on every position where you can expect antibodies to bind. You can ask yourself, if it’s wise to experiment with creating such a virus. I think it’s not, but linking to the experiment won’t undo the experiment.

What you see is that yes, when you fully cover H5N1 in glycans, you end up with a virus that escapes the vaccine induced antibody response against it, both in vitro and in vivo. It is however, not an inherently very virulent virus when you cover it in these glycans, because the innate immune system evolved to recognize viruses pulling this trick. To make the virus actually scary under these conditions, you have to get rid of the cellular immune response.

You have to remember, that the experiment of putting glycans everywhere, is not identical to what happens in nature. Yes, viruses respond to antibodies by adding glycans. But they also add other mutations, that compensate for the structural changes induced by the glycans. And of course, they evolve different variants of their proteins, that add the glycans on different positions (the quasispecies model).

But what I find far more interesting myself, is what happened in Egypt, where they’re dumb enough to vaccinate their chickens against H5N1:
Studying the progressive genetic changes in A/H5N1 after long-term circulation in poultry may help us to better understand A/H5N1 biology in birds. A/H5N1 clade 2.2.1.1 antigenic drift viruses have been isolated from vaccinated commercial poultry in Egypt. They exhibit a peculiar stepwise accumulation of glycosylation sites (GS) in the haemagglutinin (HA) with viruses carrying, beyond the conserved 5 GS, additional GS at amino acid residues 72, 154, 236 and 273 resulting in 6, 7, 8 or 9 GS in the HA.
So yes, in the vaccinated Egyptian chickens, we see the van den Bosschean doomsday scenario. There is a “peculiar stepwise accumulation of glycosylation sites” observed, in the main protein targeted for neutralization. There’s no clear evidence of decreased or increased virulence of these viruses: They generally just keep killing every single chicken they infect. There’s also no apparent detrimental impact on the transmission of these viruses, except for the very last glycan added.

The purpose of these glycans, appears to be to allow the virus to persist in its host. In mice we also see that the new glycans that started emerging in human influenza a few years ago, have the effect of increasing replication of the virus, virulence and antibody evasion.

It’s worth noting, that despite an increase in vaccination of elderly against influenza, we’re not seeing a decline in influenza deaths. In 2018, before the SARS2 pandemic starts distorting everything, the United States had the most influenza deaths since the 1967-77 season. This despite about half of elderly being vaccinated. It seems influenza evolves in response to vaccination, to become deadlier.

Of course, with far less of the population being vaccinated against influenza and with most of the people who are vaccinated having been infected by influenza many times before they received a vaccine against it, the selective pressure on influenza is less intense than it is for SARS-COV-2. In addition, SARS-COV-2 is inherently just a nastier virus than influenza: SARS2 can infect endothelial cells, it can kill T cells and it can draw T cells into the brain. Normal season influenza can’t do any of this.

SARS-COV-2 is evolving very rapidly for a corona virus and as I’ve mentioned before, we notice that it’s rapidly adding these glycans. JN.1 mutated to add a glycan at either S:30 by deleting S:31, or by adding it on S:22. That puts the glycan on the N1 loop.

But now we see the next glycan emerge, on 188, by changing 190 to Serine or Threonine. The version that’s now conquering the world is called LP.8.1. It adds the glycan on 188 and changes some amino acids next to it to adjust to the new glycan. But then it takes a next step. It changes S:679 to Arginine, which further improves the polybasic Furin cleavage site, by adding another basic amino acid. That’s now the most rapidly spreading version.

I first pointed this out a year ago that it was improving the furin cleavage site, but those lineages were unable to compete against lineages that added new glycans. But now we see a lineage that added the glycans and on top of that, now improves the furin cleavage site.

And some of you may wonder: Why keep track of every little detail? Who cares about any of this? Well, this virus is out there, damaging brains and immune systems of everyone. There’s an entire generation of children constantly getting reinfected by it.

We know what we see in chickens, with influenza: When you vaccinate them against it and they keep getting infected with it, the virus gradually evolves to evade the antibodies and merely grows more virulent. H5N1 now kills 90% of chickens within 48 hours.

And quite frankly, I don’t like what we’re seeing. This is how many people in Denmark catch mycoplasma pneumonia now:

1mycoplasma.png


If this is immunity debt, it comes with one hell of an interest rate. In Japan they’re seeing record breaking numbers of cases too, unseen since they began tracking numbers in 1999. Mycoplasma pneumoniae is the second most common cause of pneumonia.

So what’s the perpetrator? The lockdowns are being thrown under the bus right now. But as I warned about long ago, nobody really knows what happens when you have an IgG4 response in the lungs to a common respiratory virus. And then there is the fact that the immune system has to devote its limited T cell capacity to one single new virus. And then on top of that, you’re dealing with a virus that kills T cells and of course irritates the lungs.

But I want to point out again, that a natural infection by a new virus, will lead to a balanced immune response: The innate immune response is strengthened through exposure to such a virus. This innate immune response can handle very different viruses roughly equally well. As an example, you see that an infection by SARS-COV-2, improves the ability of the alveolar macrophages in the lungs to subsequently protect the body against Influenza.

Only when the innate immune response can’t handle it on its own, is an antibody response produced to a novel agent. But after vaccination against SARS2, antibody concentrations are about 50 times higher than after natural infection. So we shifted the balance in the lungs of most of the population, towards a highly specific adaptive immune response, targeted at SARS2.

You can go back and read my posts about all of this, back in 2021 and 2022. I warned you that we were at risk of seeing all sorts of other respiratory pathogens start to take over in the lungs, because the immune system was stuck with this abnormal adaptive response targeted at SARS2 and the innate immune response was suppressed.

Now we’re stuck with a world where everyone is just coughing all the time. Queen Camilla, King Charles wife, can’t show up in public because she has a cough that just doesn’t go away and feels tired all the time.

I warned you about all of this. You can’t expect the adaptive immune response to keep this virus under control for us. The innate immune system has to deal with rapidly mutating respiratory viruses of this nature. The adaptive immune response, has the job of discriminating against virulence associated epitopes.

That’s what the antibodies are supposed to do: Imagine your neighbor catches a mild virus of SARS2 and you catch a nastier version. You’re both of similar age and overall health. You will have higher antibody concentrations as a result and they will react more strongly with your version of SARS2, than with the version your neighbor caught.

This then gives a selective advantage to the milder version your neighbor caught, because it stands a better chance of reinfecting you, than the nastier version you caught. You see this in survivors of the 1918 pandemic influenza: They have highly evolved antibodies against it (affinity maturation), that only react with the 1918 virus, but not other influenza variants. That’s why we did not end up stuck with endless waves of very nasty influenza: The survivors gave the nasty influenza a survival disadvantage, through their adaptive immune response.

All of this could have been avoided.
 

Heliobas Disciple

TB Fanatic
Interesting comment exchange on the above article with references to Geert:



LSWM Lives Matter
December 5, 2024 at 3:08 am

Very interesting and informative post, thank you.

> The purpose of these glycans, appears to be to allow the virus to persist in its host.

Vanden Bossche posted a recent article (29th November) on his (now pay-walled) Substack in which he talks about the glycosylation of the N-Terminal Domain. Honestly, the article was very difficult for me to understand but there was one part that really took me by surprise. I quote:

“I do not concur with the notion that SC-2 causes chronic infection. I believe instead that the repeated detection of the virus is due to prolonged adsorption of SC-2 to patrolling DCs in the URT.”

Dr. GVB is obviously aware of the class switch from IgG3 to IgG4 induced by the mRNA vaccines. You’ve described many times how these tolerogenic antibodies prevent various branches of the immune system from killing infected cells. Yet GVB doesn’t believe that this would be causing widespread chronic COVID infections? That’s a little strange.

And you also have to consider the wastewater data. You’ve shared this graph before, showing SARS-CoV-2 concentrations in San Francisco sewage:

https://www.rintrah.nl/wp-content/uploads/2024/08/1areaundercurve.jpg

You can clearly see that many of the viral “lows” in wastewater from 2022 onwards are even HIGHER than the viral “peaks” during 2020 and 2021, which seems to suggest a significant percentage of the population suffering from persistent infections. I recall the “variant trackers” on Twitter recently discussing case reports of people with THREE YEAR persistent Delta infections.

So, if GVB was correct about the virus being confined to the upper respiratory tract and not persisting elsewhere in the body, then we wouldn’t be seeing massive amounts of virus in the sewage. Don’t get me wrong, I really like Geert, he is a hero for sounding the alarm, but he does seem to examine things in a very “black or white” way if you know what I mean.

So I am starting to lean more towards your predictions, that these future variants with glycan shields will resemble something more like latent TB or HIV rather than a highly virulent virus that people will succumb to very quickly (as Geert is predicting). But obviously it’s impossible to predict with 100% certainty what’s going to happen. Only time will tell.



Radagast
December 5, 2024 at 3:25 am

Yeah GvdB diverges from consensus in a lot of peculiar ways:

-Doesn’t think CD8 t cells kill infected cells.

-Doesn’t think persistent infections in immunocompromised people lead to new variants evolving.

-Thinks immunity in the vaccinated now depends on polyreactive non-neutralizing IgM antibodies.

-Doesn’t seem to want to acknowledge long COVID is a serious problem in vaccinated and unvaccinated people.

-And now apparently doesn’t think this virus causes persistent infections.

As much as I appreciate his willingness to warn about the risks of mass vaccination against this virus, I’m not convinced of all these esoteric hypotheses.

Nobody is right all the time. Keep in mind, GvdB also didn’t anticipate the IgG4 problem.

Vaccination has been a mistake, but what the exact consequences will be remains to be determined.

My expectation is it will look like what we’ve seen with H5N1 in chickens: Steadily rising virulence and increased glycosylation, as the population gradually suffers an increase in all sorts of respiratory infections and infections by SARS2 become increasingly persistent.

Hopefully younger and unvaccinated people will benefit from the apparent increased vulnerability of highly glycosylated variants to the various mechanisms of the innate immune response.
 

Heliobas Disciple

TB Fanatic
(fair use applies)


Congo Officials Provide Update on Mystery Disease That's Killed Dozens
Published Dec 05, 2024 at 12:05 PM EST
By Rachel Dobkin

Public health officials in the Democratic Republic of the Congo provided an update on Thursday about a mystery disease that's killed dozens of people.

What Happened?

There have been 71 confirmed deaths from the flu-like disease, including 27 people who died in hospitals and 44 in the community in the southern Kwango province, according to Congo's health minister Roger Kamba. The deaths were recorded between November 10 and November 25.

Of those hospitalized, 10 died due to lack of blood transfusion and 17 as a result of respiratory problems, Kamba said on Thursday.

The minister said that there were around 380 cases of the disease and nearly half were children under the age of five.

The Africa Centers for Disease Control and Prevention (CDC) reported slightly different numbers—376 cases and 79 deaths—which the head of the agency, Jean Kaseya, attributed to problems with surveillance and case definition.


What Is the Update?

Kamba said Thursday that "the Congolese government is on general alert regarding this disease," adding that epidemiological experts are to take samples in the Panzi health zone of Kwango province and investigate the disease.

Meanwhile, Kaseya said Thursday that more information about the disease should be known in the next 48 hours as experts receive results from laboratory samples of infected people.

"There are so many things we don't know" about the disease, including whether it is infectious and how it is transmitted, Kaseya said.

The African CDC head did say the agency believes it might be a respiratory disease.

"First diagnostics are leading us to think it is a respiratory disease," Kaseya said. "But we need to wait for the laboratory results."


What Are the Symptoms of the Disease?

Authorities say that symptoms of the disease include fever, headache, cough and anemia.

"We do not know the cause but I only noticed high fevers, vomiting... and then death," Claude Niongo, a Panzi resident who said his wife and seven-year-old daughter died from the disease, told The Associated Press (AP). "Now, the authorities are talking to us about an epidemic but in the meantime, there is a problem of care [and] people are dying," he added.

Lucien Lufutu, president of the civil society consultation framework of Kwango province, said the local hospital where patients are treated is underequipped.

"There is a lack of medicines and medical supplies, since the disease is not yet known, most of the population is treated by traditional practitioners," Lufutu, who is in Panzi, told the AP.

This latest health emergency comes amid an ongoing mpox epidemic that has devastated the Central African nation, with over 47,000 suspected cases and more than 1,000 suspected deaths reported by the World Health Organization (WHO).

The WHO declared mpox, formerly known as monkeypox, a global health emergency in August following outbreaks of the virus in Africa.

This article includes reporting from The Associated Press.
 

Heliobas Disciple

TB Fanatic
I'm going to do a slight thread drift here, but it's not really a thread drift, because the point I wanted to show applies to medical reporting in general, including reporting we got on COVID for the last 5 years.

This article's headline implies that cholesterol causes dementia and the obvious reaction would be to go on the cholesterol lowering medicines to ward off the possibility of getting dementia from your high cholesterol. But if you actually read the entire article, very close to the bottom, hidden without explanation and only as a quote, and a double negative at that, is the conclusion that is the fluctuations caused by cholesterol lowering drugsthemselves that causes the dementia. The drugs. Not the cholesterol. Sound familiar?

Or am I reading it wrong?

see bolded text:



(fair use applies)


Your Cholesterol Could Be A Key Indicator Of Dementia. A Neurologist Explains The Warning Signs
Korin Miller - Women's Health
December 4, 2024 at 3:07 PM

Typically, dementia is associated with classic symptoms like confusion and memory loss. But new research finds that there could be a less obvious risk factor out there: your cholesterol levels.

The preliminary study results, which were presented at the American Heart Association’s Scientific Sessions last month, suggest that significant changes to a person’s cholesterol levels in a short period of time could put you at a higher risk of developing dementia.

The two may seem completely unrelated, but there is an association. Here’s what you need to know.

Meet the experts: Clifford Segil, DO, a neurologist at Providence Saint John’s Health Center in Santa Monica, California.


What did the study find?

The study analyzed data from nearly 10,000 people who were enrolled in a randomized clinical trial, looking into the impact of low-dose aspirin on reducing heart disease risk in Australian and American adults. The researchers concluded that aspirin is not effective for lowering heart disease risk. (The study mostly focused on white adults, so this may not be applicable to everyone.)

About one-third of the participants were taking a cholesterol-lowering medication during the study, but no one started or stopped their medication during the follow-up. During six years of yearly follow-ups, 509 participants were diagnosed with dementia and 1,760 developed cognitive decline without a dementia diagnosis.

The researchers discovered that people who had high fluctuations in their cholesterol levels had a 60 percent higher risk of developing dementia and a 23 percent greater risk of cognitive decline. Those who had stable cholesterol levels, on the other hand, lower risks of dementia or cognitive decline.


Does my cholesterol affect my dementia risk?


There is a link between having high cholesterol levels and a greater risk of developing certain types of dementia, including Alzheimer’s disease and vascular dementia, according to the National Institute on Aging (NIA). But it’s not clear how these two are related, given that cholesterol doesn’t actually enter the brain.

Still, there are some theories. “Cholesterol level is a risk factor for cardiovascular disease," says Clifford Segil, DO, a neurologist at Providence Saint John’s Health Center in Santa Monica, California. As a result, high cholesterol can rise your risk of stroke.

One form of dementia—called vascular dementia—is caused by regular small strokes, he points out. “Fluctuating cholesterol levels may therefore cause fluctuating risk for strokes,” Segil says. With that, high cholesterol may raise the risk of developing certain types of dementia, he says.


What are fluctuating cholesterol levels?

Fluctuating cholesterol levels means that a person has cholesterol levels that change significantly in a short period of time, like from year to year, Segil explains. But this isn't common.


In clinical practice, I have never seen fluctuating annual cholesterol levels in patients not on lipid-lowering medications,” he says. (Lipids are fatty compounds, and cholesterol is a type of lipid.)


How can I improve my cholesterol?

Your cholesterol levels are influenced by a range of things, including your diet, age, and genetics. While you can’t change your genes or your age, there are some lifestyle tweaks that may be helpful for managing your cholesterol. The American Heart Association recommends these:

Eat heart-healthy foods like a variety of fruits and vegetables, whole grains, lean meats, fatty fish, and plant-based sources of protein.
Be physically active.
Try to reach and maintain a healthy weight.
Avoid smoking.

If you have high cholesterol and lifestyle tweaks don’t help, the AHA notes that some people need to take medicine to lower their levels.
 

Heliobas Disciple

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(fair use applies)


Severe COVID-19 may be a risk factor for multiple sclerosis

by Örebro Universitet
December 2, 2024

COVID-19 may be a risk factor for multiple sclerosis (MS). This has been shown by new research at Örebro University and Örebro University Hospital, Sweden. The study is published in the journal Brain Communications.

"We saw a raised risk of MS among people who had severe COVID-19. However, only an extremely small number of people who had severe COVID-19 received a subsequent MS diagnosis," says Scott Montgomery, professor in clinical epidemiology.

Montgomery examined the records of all patients with COVID-19 that were admitted to hospital in Sweden between 2020 and 2022.

The results showed that nearly 26 per 100,000 patients with serious COVID-19 subsequently developed MS. This was more than double the risk than in those without a COVID-19 diagnosis.

"I want to make it clear that MS is an uncommon disease and very few people in this study had an MS diagnosis linked with COVID-19. Approximately 26 people with new-onset MS per 100,000 with serious COVID-19 is only 0.02%."

Montgomery suspects that the number who are diagnosed with MS following severe COVID-19 will increase over the years after the pandemic.

"It can take up to 10 to 20 years until an MS diagnosis following relevant exposure to the brain or spinal cord. The extent to which serious COVID-19 is a cause of MS will become clearer in several years," says Montgomery.

He hopes that the research will result in earlier diagnosis of MS among those affected so they can be treated before the development of more advanced disease.

"Since the majority of people who were infected will not develop diseases such as MS, they should not worry. However, people with symptoms should seek medical advice. The earlier patients with MS are treated, the better quality of life they will have, because treatments delay the worsening of the disease," says Montgomery.

He also emphasizes the importance of ensuring that everyone is up to date with their vaccinations to prevent infections.

"There is a connection with the severity of COVID-19. More serious COVID-19 is associated with greater risk of MS, possibly uncovering latent MS." Similar research is underway on other diseases that could be caused by COVID-19.

"If we can follow the patient group that has been admitted to hospital for severe COVID-19 and identify diseases that are more likely to develop subsequently, we may be able to monitor for these diseases and hopefully help patients in a timely manner."

More information: Scott Montgomery et al, SARS-CoV-2 infection and risk of subsequent demyelinating diseases: national register-based cohort study, Brain Communications (2024). DOI: 10.1093/braincomms/fcae406
Journal information: Brain Communications
Provided by Örebro Universitet
 

Heliobas Disciple

TB Fanatic
This is the disease in the Congo I've posted on the last 2 days. I'm going to post a new thread on this topic because it deserves it's own thread now that it's hit our shores. :(


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Patient with flu-like symptoms isolated at Cleveland hospital after Africa trip. What we know
Chad Murphy, Akron Beacon Journal
Updated Fri, December 6, 2024 at 5:54 PM UTC

A patient displaying flu-like symptoms was isolated at University Hospitals in Cleveland after recently returning from a trip to Africa, 19 News is reporting, but has since been released.

The patient had flown in from Tanzania, a neighboring country to Congo, where a mysterious illness has killed more than 100 people.


Here's what to know.

Patient in isolation had just returned from Tanzania

UH staff were “utilizing proper masking and isolation protocols,” 19 News reports, after a patient with flu-like symptoms arrived to UH St. John Medical Center’s Emergency Department.

A hospital spokesperson told the station that the patient recently traveled from Tanzania to Cleveland Hopkins International Airport.

The patient was isolated and under evaluation, according to the spokesperson, and their condition was reported to the Ohio Department of Health. He was released Friday, 19 News reports.

Infectious disease specialists at UH and the state health department determined the cause of the patient’s symptoms was routine, per 19 News.


Mysterious flu-like disease kills 143 in Congo

A mysterious flu-like disease in the Democratic Republic of the Congo has killed 143 people during the past month, USA TODAY reports.

Reuters reports those infected experience flu-like symptoms, including high fever and severe headaches. The disease seems to affect women and children over age 15 the worst.

The cases are centered in Congo's southwestern province, Kwango, where at least 376 people have been infected since October, according to the website FluTrackers.com, which cites local sources.

Congo borders Tanzania to the east. However, the Kwango province is on the opposite side of the country from Tanzania.
 
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