CORONA Main Coronavirus thread

Heliobas Disciple

TB Fanatic
HD, at least they’re now saying openly it is the vaxxed who are the most sickest!

I’m not “counting my own chickens” before they’re hatched, I can promise you that. But I ***think, I’m watching this happen in real time with two coworkers. At least one of them, anyway.
She’s vaxxed up. She’s only worked for us since late spring? That girl has been sick the entire time.
She’s had covid 2-3 times. (Twice since our place? )…..she’s called off sick at LEAST once monthly.
Two weeks ago she had a coughing, snotty, hacking, drippy cold bug.
(I caught that from her but it was NOTHING as bad as hers was, not at all. I immediately doubled up on protocols, though, too)


This Sunday, she took ANOTHER Covid test but turns out she has a severe flu….stomach, fever, GI both ends , shaking type flu and not getting any better. A different coworker saw her yesterday and told me the girl looks very bad.

She’s in late 20’s probably or very early 30’s…overweight, probably other issues too, and from what I’ve seen, she lives on fast food/junk.

The same thing with another kid there. Same overweight issues and ALWAYS sick with something. It’s unreal!

I feel bad for them, honestly.
I could go on and on.

I'm sorry for them also. No one deserves that. Even if they make an unwise decision thinking they are making a good one.

As for the percentages of vaxxed dying - it's still a larger percentage of the group of unvaxxed who are dying. If 80% of the population is vaxxed, and the vaxx offered no help at all, 80% of those deaths would be among the vaxxed. But it's not - it's only 58%, so right now the vaxx does help prevent serious illness and death in some who are vaxxed vs. those who are not vaxxed. That's not disputed, even Geert discusses this and why it's helping them (see the interview transcript I posted a few posts up). HOWEVER, the percentage of those who have been harmed by the vaxx among the vaxxed and the unvaxxed is a different story because obviously zero percent of the unvaxxed are harmed by the vaxx (unless they have some effects from shedding). We still don't have an accurate answer of how many vaxxed have been harmed by it, or will be harmed by it in the years to come, especially if Geert's predictions come to fruition. But it's going to be a lot larger than 0% of the unvaxxed .... Of course, no MSM outlet is going to bring that comparison up. Nor will we get a comparison of the percentage of unvaxxed who died of covid vs. the percentage of vaxxed who died of or had other long lasting effects from the vaxx so someone still on the fence can factor that into their decision making process.

Happy and healthy Thanksgiving to all on the thread!

HD
 

Heliobas Disciple

TB Fanatic
(fair use applies)


BREAKING! SARS-CoV-3 That Poses High Human Threat Identified In Bats In Yunnan Province In China. A Recombinant SARS-CoV-2 And SARS-CoV-1
Thailand Medical News
Nov 25, 2022 5 hrs ago

Chinese researchers from Sun Yat-Sen University, Fudan University, Yunnan Institute of Endemic Disease Control and Prevention, Yunnan University, National Institute for Viral Disease Control and Prevention-Beijing, City University of Hong Kong along with Australian scientists from University of Sydney have discovered a recombinant strain of SARS-CoV-2 and SARS-CoV-2 viruses in bats found in the Yunnan province of China.

As the new recombinant coronavirus can effectively utilize the human ACE2 receptor, it poses an immediate high zoonotic risk! Many scientists and COVID-19 News outlets have already started labelling it as SARS-CoV-3!

In fact, unverified sources are claiming that this new virus is already causing small clusters of infections among people in parts of China. Considering unexplained hard tactics to control the current COVID-19 surges occurring across the country while the West are simply taking a policy of leaning to live with the virus coupled with the fact that China has been reluctant to share genomic sequencing data and also publicly inform what variants and sub-lineages are responsible for the current surges in their country, these claims could well be true!

Bats are reservoir hosts for many zoonotic viruses. Despite this, relatively little is known about the diversity and abundance of viruses within bats at the level of individual animals, and hence the frequency of virus co-infection and inter-species transmission.

Utilizing an unbiased meta-transcriptomics approach, the study team characterized the mammalian associated viruses present in 149 individual bats sampled from Yunnan province, China.

Interestingly, this revealed a high frequency of virus co-infection and species spillover among the animals studied, with 12 viruses shared among different bat species, which in turn facilitates virus recombination and reassortment.

Importantly, the study team identified five viral species that are likely to be pathogenic to humans or livestock, including a novel recombinant SARS-like coronavirus that is closely related to both SARS-CoV-2 and SARS-CoV, with only five amino acid differences between its receptor-binding domain sequence and that of the earliest sequences of SARS-CoV-2.

Detailed functional analysis showed that this recombinant coronavirus can utilize the human ACE2 receptor such that it is likely to be of high zoonotic risk.

The study findings highlight the common occurrence of inter-species transmission and co-infection of bat viruses, as well as their implications for virus emergence.

The study findings were published on a preprint server and are currently being peer reviewed.

It should be noted that whenever a single cell or organism carries more than one closely related virus at the same time there is a risk of viral crossover.

Hence, various coronaviruses and also other virus species found in bats is a conducive environment for more recombinant and reassortant events.

The study team found two SARS like viruses in the Bats ie BtSY1 and BtSY2 with one being closer related to original SARS-CoV and the other closer to SARS-CoV-2 upon detailed Spike and N gene analysis.

Alarmingly however, upon when looking at the RdRp gene, both BtSY1 and BtSY2 seems to cluster around the SARS-CoV-2 original strain but some regions of BtSY2 are SARS1 like, others SARS2 like, strongly indicating that the virus is a recombinant between SARS-CoV1 and SARS-CoV-2!

Significantly, the receptor binding domain of BtSY2 is (94% identity) is closely identical to the original SARS-CoV2 Wuhan strain and the NTD is even more similar.

The study team using detailed functional analysis found that the Bat SARS-like coronavirus BtSY2 has the ability to bind to the human ACE2 receptor, and even has slightly higher affinity than the original SARS-CoV-2 Wuhan strain, making it an immediate threat to humans.

Three of the five substitutions in the RBD - Q498H, N501Y and H519N - have been reported to increase affinity to human ACE2, and notably, the N501Y substitution is present in the Alpha, Beta, Gamma and Omicron variants of SARS-CoV-2.

In addition, the study team found that the nsp7-nsp14 proteins (in which nsp12 is the replicase, i.e., RdRp) of BtSY2 were closely related to those of SARS-CoV-1.

A comparative study showed that SARS-CoV can replicate more rapidly than SARS-CoV-2 in vitro, while another suggested that nsp14 is likely associated with virulence.

Worryingly, these data tentatively suggest that BtSY2 may be able to replicate rapidly with similar virulence as SARS-CoV. Although this issue merits further consideration, this virus is potentially of high risk of emergence and so should be monitored carefully.

The study team also identified another four viruses of concern, likely to be pathogenic in humans or livestock. Bat SARS-like virus BtSY1 is closely related to SARS-CoV-2, Rhinolophus bat coronavirus HKU2-like is closely related to SADS-CoV, which causes severe diarrhea and death in swine, Rotavirus A causes diarrhea in humans, while Mammalian orthoreovirus is known to have a broad host range and cause diarrhea in swine.

Interestingly, all these viruses of concern were found in more than one bat species in the samples, suggesting that these potentially zoonotic viruses may have a broader host range or have a higher rate of spillover than other viruses.

With mankind invading more and more into natural reservoirs of wild mammals it is only a question of when humans will pick up the next virus(if they have not already done so!) and which one it will be. Recombination of viral genomes is happening and the reservoir of new but closely related species are expanding rapidly.
 

psychgirl

Has No Life - Lives on TB
The clock is ticking, this time though the source is well known. I guess we need to keep an eye open at flutrackers.
Yep

This possibility reallllly bums me out.
And….I’ve been fighting this “weird cold bug” for 8 days now.
Started last Thursday
Up and down…feeling achey again today but im at work. .
Well, a coworker tested positive this morning
I worked with her for 10 hours Wednesday


Last Saturday, I worked with ANOTHER positive coworker for four hours.


Im wondering if IM the one who has it amd been me all along spreading it?
 

Heliobas Disciple

TB Fanatic
Yep

This possibility reallllly bums me out.
And….I’ve been fighting this “weird cold bug” for 8 days now.
Started last Thursday
Up and down…feeling achey again today but im at work. .
Well, a coworker tested positive this morning
I worked with her for 10 hours Wednesday


Last Saturday, I worked with ANOTHER positive coworker for four hours.


Im wondering if IM the one who has it amd been me all along spreading it?
Feel better! I assume you tested negative. Maybe you just don't test positive (even if you have it). Those tests are definitely not perfect....

HD
 

Heliobas Disciple

TB Fanatic
Funeral CEO Reveals the Shocking Number of Deaths He’s Seeing This Year
Facts Matter with Roman Balmakov
3 days ago

View: https://www.youtube.com/watch?v=baKvcSgZSV0
15 min 48 sec (includes a paid promotion in the middle)



CEO of largest funeral home company in the USA told his stockholders on the quarterly earnings call that in the third quarter of 2022, they did 15% more calls than they did in the third quarter of 2019. When covid first came to be, in 2020, they had a 20% increase - expected for a pandemic. But 2020, there aren't that many covid deaths - and yet they went up 15% this quarter compared to 2019. Similar increase in life insurance claims.
 

Heliobas Disciple

TB Fanatic
The new virus I posted about yesterday is starting to make more 'mainstream' news in the UK.


ETA:
EDITED OUT THE ARTICLE. I forgot the site is on the proscribed list of sources we can't post or reference. Sorry!

HD
 
Last edited:

Heliobas Disciple

TB Fanatic
(fair use applies)


Covid-like virus is discovered lurking in bats in southern China - and scientists say it has the potential to jump to HUMANS
By Jonathan Chadwick For Mailonline
Published: 05:06 EST, 25 November 2022 | Updated: 05:44 EST, 25 November 2022
  • Researchers in China have taken samples from 149 bats across Yunnan province
  • They found five 'viruses of concern' that have the potential to spread to humans
  • The Covid-like virus known as BtSY2 has similarities to SARS-CoV-2

A Covid-like virus discovered lurking in bats in southern China is one of five with the potential to jump to humans, scientists say.

The virus, known as BtSY2, is closely related to SARS-CoV-2, the virus that causes Covid, and is 'at particular risk for emergence'.

It's one of five 'viruses of concern' found in bats across China's Yunnan province that are 'likely to be pathogenic to humans or livestock', the scientists say.

The team warn of potential new 'zoonotic' diseases – those caused by pathogens that pass to humans from other animals.

The research was led by researchers at Sun Yat-sen University in Shenzhen, the Yunnan Institute of Endemic Disease Control and the University of Sydney.

It has been detailed in a new study published as a preprint paper, yet to be peer-reviewed, on the bioRxiv server.

'We identified five viral species that are likely to be pathogenic to humans or livestock, including a novel recombinant SARS-like coronavirus that is closely related to both SARS-CoV-2 and 50 SARS-CoV,' the team say in the paper.

'Our study highlights the common occurrence of inter-species transmission and co-infection of bat viruses, as well as their implications for virus emergence.'

For the study, the researchers collected rectum samples from 149 individual bats representing 15 species, in six counties or cities in China's Yunnan province.

RNA – nucleic acid present in living cells – was extracted and sequenced individually for each individual bat.

Concerningly, the researchers noted a high frequency of multiple viruses infecting a single bat at one time.

This can lead to existing viruses swapping bits of their genetic code – a process known as recombination – to form new pathogens, according to Professor Jonathan Ball, a virologist at the University of Nottingham.

'The main take-home message is that individual bats can harbour a plethora of different virus species, occasionally playing host to them at the same time,' Professor Ball, who was not involved in the research, told the Telegraph.

'Such co-infections, especially with related viruses like coronavirus, give the virus opportunity to swap critical pieces of genetic information, naturally giving rise to new variants,' he said.

BtSY2 also has a 'receptor binding domain' – a key part of the spike protein used to latch onto cells human cells – that's similar to SARS-CoV-2, suggesting the virus can infect humans.

'BtSY2 may be able to utilize [the] human ACE2 receptor for cell entry,' the team add.

ACE2 is a receptor on the surface of human cells that binds to SARS-CoV-2 and allows it to enter and infect.

Yunnan province in southwestern China has already been identified as a hotspot for bat species and bat-borne viruses.

A number of pathogenic viruses have been detected there, including close relatives of SARS-CoV-2, such as bat viruses RaTG1313 and RpYN0614.

The team did not speculate on the origins of SARS-CoV-2, which is related to the SARS-CoV-1 virus that caused the 2002-2004 SARS outbreak.

Evidence already suggests SARS-CoV-2 originated in horseshoe bats, although it's likely the virus passed to humans through pangolins, a scaly mammal often confused for a reptile.

Likewise, it's thought the lethal outbreak of the Ebola virus in Western Africa between 2013 and 2016 stemmed from bats.

Yunnan, the region identified by the new study, is also home to pangolins, which are consumed as food in China and are also used in traditional medicine.

According to a 2021 study in the journal Science of the Total Environment, it's possible the virus jumped from bats to Sunda pangolins and masked palm civits in Yunnan.

They were then captured and transported to a wildlife market in Wuhan, more than 1,200 miles away, where the initial Covid outbreaks occurred.
 

psychgirl

Has No Life - Lives on TB
Feel better! I assume you tested negative. Maybe you just don't test positive (even if you have it). Those tests are definitely not perfect....

HD
I didn’t test this time because I never had a fever , I just felt rotten.
Maybe I should have anyway, but by now it’s probably too late even though I’m still not totally up to par.
How long do you think the virus will test positive?
 

Heliobas Disciple

TB Fanatic
I didn’t test this time because I never had a fever , I just felt rotten.
Maybe I should have anyway, but by now it’s probably too late even though I’m still not totally up to par.
How long do you think the virus will test positive?
I don't know but it's probably too late to test now. How are you feeling? Is everyone at work feeling better?

HD
 

Heliobas Disciple

TB Fanatic
(fair use applies)


Omicron BQ COVID-19 Variants Now Make Up Over Half of US Cases: CDC

By Mimi Nguyen Ly
November 27, 2022

The COVID-19 Omicron subvariants BQ.1 and BQ.1.1 have risen to comprise over half of new coronavirus infections in the United States in the past week, according to the Centers for Disease Control and Prevention (CDC).

The CDC’s weekly variant update shows that BQ.1.1 has been responsible for 29.4 percent of new closely followed by BQ.1 which accounted for 27.9 percent. Together, the two strains make up 57.3 percent of new coronavirus infections recorded in the United States in the week ending on Nov. 26.

Meanwhile, the Omicron BA. 5 subvariant, which was dominant in the United States from July to October, now comprise about a fifth of new COVID-19 cases.

According to the World Health Organization, BQ.1 and BQ.1.1 are among the more than 300 sublineages of the Omicron variant circulating globally.

The two subvariants have genetic mutations that make it harder for the immune system to combat the virus. This enables it to infect people who had immunity from either previous infections or vaccinations. The risk of severe illness remains highest for the elderly and those with underlying health conditions whose immune systems are compromised.

Symptoms for BQ.1. and BQ1.1. appear to be similar to previous variants of COVID-19 for now and may include fatigue, muscle or body aches, headache, sore throat, cough, congestion or runny nose, shortness of breath or difficulty breathing, nausea or vomitting, and diarrhea.

The subvariants are circulating amid the spread of other respiratory viruses, including respiratory syncytial virus (RSV) and influenza.

Resistance to Antibody Treatments


Both Omicron BQ.1 and BQ.1.1 are “likely to be resistant” to currently used anti-SARS-CoV-2 monoclonal antibodies (mAbs)—specifically, bebtelovimab and Evusheld (tixagevimab and cilgavimab), according to the National Institutes of Health (NIH). This is due to mutations in the spike protein of BQ.1 and BQ.1.1.

The NIH noted that ritonavir-boosted nirmatrelvir (Paxlovid), remdesivir, and molnupiravir are still “expected to be active against these resistant subvariants.”

Separately, a study by scientists in Germany published Nov. 18 in The Lancet Infectious Diseases journal showed that BQ.1.1 “is resistant to all approved antibody therapies” in the country. The study showed that use of various mAbs were unable to cause “appreciable neutralisation” of BQ.1.1.

Eric Topol, founder of the Scripps Research Translational Institute, told TIME in October that BQ.1.1 is the more concerning of the two subvariants, as it is “just riddled with troublesome mutations” that could “pose a threat to our immune system’s response.”

Resistance to Vaccines

Both BQ.1 and BQ.1.1, compared to earlier Omicron versions, also appear to be better at evading neutralizing antibodies generated by COVID-19 vaccination or the body’s immune system, according to a study published Nov. 22 in the journal Cell Host & Microbe.

“In general, the subvariants BQ.1 and BQ.1.1 are much better compared to prior variants at evading the [vaccine] booster-mediated antibody response—the neutralizing antibody titers are clearly much lower,” said Shan-Lu Liu, the senior author of the study, per Ohio State News.

Liu, a professor in the Department of Veterinary Biosciences and in the Department of Microbial Infection and Immunity at The Ohio State University, said that people should “be aware while traveling and gathering over the holidays that SARS-CoV-2 variants are continuing to evolve.”

The study he and colleagues conducted suggested that BQ.1 and BQ.1.1 can enter the cells of the human body more efficiently and force those cells to fuse together, which is a step in viral infection that can cause the disease to progress further, thereby increasing the risk of people developing symptoms—including severe symptoms—and becoming infectious.

“From my perspective, this is cause for concern because the original Omicron variant was not very pathogenic—it did not cause much cell fusion at all,” Liu said. “But we now see a trend with these new subvariants of increased cell fusion, and that trend puts the virus in a better position to cause infection and pathogenesis.”

Pfizer-BioNTech stated on Nov. 18 that its latest Omicron BA.4/BA.5-adapted bivalent booster can induce neutralizing antibodies against BQ.1.1.

Meanwhile, Moderna stated on Nov. 14 that its Omicron-targeting bivalent booster still showed “robust neutralizing activity against BQ.1.1.” in an analysis of about 40 participants. This, however, represented a 5-fold drop in titers compared to BA.4/BA.5.

XBB a New Variant of Concern

Besides BQ.1 and BQ1.1., the CDC noted in its weekly variant update that a new COVID-19 variant of concern referred to as XBB now comprises 3.1 of new cases in the country.

Preliminary estimates (pdf) in early November via the agency suggested that XBB, first named by scientists in September, is doubling in proportion about every 12 days.

By October, the CDC stated it was “keeping a close eye” on the XBB subvariant.

White House chief medical adviser Dr. Anthony Fauci said on Nov. 22 that protection with the new vaccine boosters, which were designed against Omicron BA.5, “is diminished multifold with XBB” and as such, people who are vaccinated “could expect some protection, but not the optimal protection.”
 

psychgirl

Has No Life - Lives on TB
I don't know but it's probably too late to test now. How are you feeling? Is everyone at work feeling better?

HD
No, not yet, and I’m gonna bet there’ll be others come down with Covid this week.
There’ll all susceptible to illness in that building
I’m feeling 95% better. Thank God!
Nothing resembling Covid yet, not in this house

I think I’d have it by now, don’t you? It’s been five days since full exposure.
 

psychgirl

Has No Life - Lives on TB
I don't know but it's probably too late to test now. How are you feeling? Is everyone at work feeling better?

HD
Actually….I did consider taking one of those quick/rapid antibody blood stick tests at Kroger pharmacy
But antibodies take a couple of weeks to develop don’t they?

I’d do it just out of curiosity
 

Heliobas Disciple

TB Fanatic
Actually….I did consider taking one of those quick/rapid antibody blood stick tests at Kroger pharmacy
But antibodies take a couple of weeks to develop don’t they?

I’d do it just out of curiosity
They have rapid antibody tests? The only one I had heard about were around $80 at some lab in the back of walgreens or cvs. Do you know more about the rapid antibody test? Do you have more info? Thanks!
 

Heliobas Disciple

TB Fanatic
(fair use applies)


Next major COVID variant IS poised to be more deadly, doctors warn after studying patient who harbored Omicron for six months
By Cassidy Morrison Senior Health Reporter For Dailymail.Com
Published: 13:06 EST, 28 November 2022 | Updated: 15:40 EST, 28 November 2022
  • South African researchers found that the Covid infection mutates over time
  • An HIV-infected patient saw cell death and fusion increase over six months
  • This indicates a new more dangerous variant could arise from milder omicron

The world's next major Covid variant is poised to be more severe than the mild strains that are currently world-dominant, according to a new study.

The ultra-infectious Omicron strain emerged almost exactly a year ago and its mutated spinoffs have risen to the top in virtually every country in the world.

They are far milder than the older versions of the virus and many researchers believed they represented a kind of end game for Covid’s evolution, which like many viruses before it, mutate to be more mild so they can spread more easily.

But researchers in South Africa say the virus still has the potential to get deadlier after examining an immunocompromised HIV patient who harbored the virus for half a year.

Over time, the virus evolved to cause more cell death and cell fusion, leading to increased inflammation in the lungs. These effects more closely resembled those of the ancestral Covid strain than the Omicron strain, according to Professor Alex Sigal, the virologist who led the study.

The patient studied is one of the longest known sufferers of Omicron, which itself is widely believed to have evolved in someone with a severely weakened immune system.

Immunocompromised people cannot adequately clear out infection, which allows the virus to continually replicate and mutate in their body over time, before spreading to others with its new alterations.

Still, the findings from South Africa represent just one theory about the future of Covid's spread and protection gained through vaccination and prior infection puts the US - and world - in a stronger position to beat back another deadly surge.

The finding comes amid warnings that China's unrelenting Covid outbreak could spawn a doomsday variant which has the potential to send the world back to square one in its fight against the virus.

China's draconian 'zero-Covid' policy has driven economic hardship and residents back into isolation. Cases have doubled within a fortnight across the country, where the pandemic began almost three years ago. A record 40,000 people are now testing positive every day, with millions subject to restrictions.

The omicron variant has proven to cause less severe disease than the original Covid strain as well as the alpha and delta variants.

The team’s findings do not bode well for the global response to the ongoing public health issue.
The latest study was carried out by researchers from the Africa Health Research Institute in the South African city of Durban, which was the first lab to test the original Omicron against the older vaccines and show that strain significantly weakened their effects.

Researchers looked at regular blood samples from the long-term Covid patient who was infected with Omicron.

They sequenced viral samples from the patients blood shortly after they were diagnosed with Covid, then within the first month of diagnosis, and then at three-month intervals.

They studied changes to the virus' genetic makeup, as well as how infected human cells behaved.

As time from first diagnoses went on, cell death became more frequent.

When the patient was first infected with Omicron, around four per cent of human cells that were infected died. That was about a third the level of the Wuhan strain that first emerged in late 2019, which killed about 12 per cent of infected cells.

At day six after diagnosis, less than six per cent of cells were detected as dead. By day 20, that rate increased to nearly seven per cent.

The frequency of cell death, which represented how severity of disease changed, spiked again to nearly 10 per cent at day 190, roughly the same rate as that of the original Wuhan strain.

Dr Sigal said: ‘It's not simple because early virus was attenuated. However, by parameters we measured, it became less attenuated, showing that long-term evolution does not always lead to attenuation.

‘Therefore, the next major variant, if it comes, may not necessarily be as mild as Omicron.’

Covid-19 disease leads to cell death, causing systeming inflammatory effects.

The finding came as a shock to the researchers, who hypothesized that strains of Covid-19 will become less virulent and infectious over time judging by the relative mildness of omicron compared to previous variants.

In China, the daily case rate began to shoot upwards one month ago and this weekend hit 39,791 — nine in 10 of which were asymptomatic, according to data from the National Health Commission. The more Covid is permitted to spread, the more it can replicate and mutate.

Dr Simon Clarke, a microbiologist based at the University of Reading, told MailOnline: 'Every single Covid infection presents the virus with an opportunity to change its characteristics.

'The idea that this only leads to decreased lethality is simply wrong; having effective population-wide immunity seems to have had a much more substantial protective effect, but compared to the vaccines used here it seems that China's is less effective, which might be contributing to their problem.

The US has been bracing for a surge in Covid during the winter months which, for the most part, has been overshadowed by the explosion of RSV and flu cases.

Patients in many states where hospitals are swamped are being transferred hundreds of miles in helicopters in search of an available bed.

Even major hospitals such as Mass General for Children in Boston and Baltimore’s Johns Hopkins are stretched thin.

But the latest pre-print publication - which has not been peer-reviewed by other scientists - came with several caveats.

The hypothesis was only testing a single patient. A much larger sample size is needed to make a conclusion about the virus’ course of evolution.

The manuscript, published last week, does not indicate that the US must revert back to blanket mitigation measures such as compulsory masking.

But it bolsters government warnings that the pandemic remains a major public health issue.

Dr Anthony Fauci, the government’s top infectious disease expert and President Joe Biden’s chief medical advisor said on Sunday that the US is ‘certainly’ still in the middle of a Covid pandemic.

‘I think the idea that forget it, this is over — it isn’t,’ he said.

More than 23,000 people on average are in the hospital for Covid every day while average daily deaths are hovering between 300 and 400.
 

Heliobas Disciple

TB Fanatic
ThailandMedicalNews reported on this a few days ago but I was waiting for a more MSM report to confirm. However, I think ThailandMedicalNews has proven itself to be ahead of the curve and I may not wait for another source to confirm in the future...



(fair use applies)


COVID-19 News: Scientists Warn That Next SARS-CoV-2 Variants To Emerge Are Likely To Be More Lethal After Identifying Such A Variant In A HIV Patient
Thailand Medical News
2 days ago

International researchers led by the Sigal lab in Durban-South Africa are warning that contrary to the fallacy that is being disseminated by many so called ‘experts’, mainstream media, COVID-19 News
outlets and health authorities that the SARS-CoV-2 coronavirus is evolving to be more milder, the next variants to emerge are likely to be more lethal and worrisome based on their recent study that identified such a variant in a HIV immunocompromised individual.

Many are making claims that based on the milder clinical manifestations of Omicron infection relative to pre-Omicron SARSCoV-2 raises the possibility that extensive evolution results in reduced pathogenicity.

In order to test this hypothesis, the study team quantified induction of cell fusion and cell death in SARSCoV-2 evolved from ancestral virus during long-term infection. Both cell fusion and death were reduced in Omicron BA.1 infection relative to ancestral virus.

Evolved virus was isolated at different times during a 6-month infection in an immunosuppressed individual with advanced HIV disease. The virus isolated 16 days post-reported symptom onset induced fusogenicity and cell death at levels similar to BA.1.

Alarmingly however, fusogenicity was increased in virus isolated at 6 months post-symptoms to levels intermediate between BA.1 and ancestral SARS-CoV-2. Similarly, infected cell death showed a graded increase from earlier to later isolates.

The study findings indicate that, at least by the cellular measures used here, evolution in long-term infection does not necessarily attenuate the virus.

The study findings were published on a preprint server and are currently being peer reviewed.


The study was led by Dr Alex Sigal at his labs at the Africa Health Research Institute in the South African city of Durban, indicated that the COVID-19 pathogen could continue to mutate and a new variant may cause more severe illness and death than the relatively mild omicron strain.

The Sigal lab using COVID-19 samples from an immunosuppressed individual has showed that the virus evolved to become more pathogenic with enhanced capabilities to cause more cell fusion and cell death.

The evolution of the virus over six months in an HIV immunocompromised patient showed that the newly emerged variant could cause more illness than the current predominant omicron strain.

The Sigal lab last year was to first test the omicron strain against vaccines and in this new study also studied the virus samples taken after six months from a HIV immunocomprised patient who was infected with the SARS-CoV-2 virus.

The study found that in the past 6 months, the virus initially caused the same level of cell fusion and death as the omicron BA.1 strain, but as it evolved those levels rose to become similar to the first version of SARS-CoV-2 identified in Wuhan in China.

The study findings hopefully will make health authorit ies and ‘experts; rethink the current complacency over COVID-19 measures based on fallacies that the SARS-CoV-2 virus is becoming milder.

It should be noted that there are millions of individuals around the world who are immunocompromised and are potential reservoirs for the evolution of the current SARS-CoV-2 variants in circulation.

2023 is indeed going to be a fun year with the way that the whole COVID-19 pandemic is being mismanaged and the over emphasis on the COVID-19 shots.

The study team also comprised of scientists from:

-The Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.

-Africa Health Research Institute, Durban, South Africa.

-Division of Infection and Immunity, University College London,UK.

-KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa.

-School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.

-Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa.

-Department of Global Health, University of Washington, Seattle - USA.

-Department of Epidemiology, Mailman School of Public Health, Columbia University, New York - USA.
 

Heliobas Disciple

TB Fanatic
And since I'm not waiting for msm confirmation, here's another article they posted last night. The owner of the site and author can be a little overdramatic and sarcastic, I edited out those comments; no use throwing out the baby with the bathwater...the science aspect of his articles is spot on and he always provides links so the reader can verify what he's saying and where he got his info.

Btw, don't want to just bring doomer news as the last few posts seem to be, but they seem to be confirming Geert's theory so thought they were post worthy.


(fair use applies)


BREAKING COVID-19 NEWS: Scientists Identify New Worrisome SARS-CoV-2 Omicron Sub-lineage CH.1.1 Spotting Delta’s P681R Mutation In Austria
Thailand Medical News
1 day ago

Researchers and virologist are extremely concerned about the emergence of a new SARS-CoV-2 Omicron sub-lineage CH.1.1 spotting Delta’s P681R mutation in Austria.

There is no data on where this strain emerged but to date it has been seen in 12 samples that were sent for genomic sequencing in patients hospitalized in Vorarlberg-Austria.

The CH.1.1 variant is a BA.2.75 descendant with the spike mutations R346T, K444T, L452R, and F486S ie somewhat similar to BQ.1.1.

Already it is a more worrisome variant as it is not only more transmissible and has a better growth advantage over the BQ.1.1 variant but because it has mutations on the NTD (spike residues 14-305), it is believed to be even more immune evasive than all the rest of the circulating variants and sub-lineages so far.

However, the debut of CH.1.1 variants spotting the Delta’s signature P681R mutation could spell problems as it means that the new sub-lineage will be more pathogenic and also likely to cause disease severity and risk of mortality.

The P681R mutation is believed to enhance cell fusogenicity and cause rapid formation of syncytia.



Previous COVID-19 News coverages have already detailed how bad the Delta surges were and how the Delta variant contributed to an increase in deaths and disease severity.

The new CH.1.1 with the P681R mutation has already bee designated in the last 24 hours.


However, the new variant has yet to be issued a name yet.

Some researchers believe that this new lineage could have originated via a recombinant event as interestingly, there seems to be a BF.7.9 (EPI_ISL_15816454 on 2022-11-08) and an AY.78 (EPI_ISL_15746291 on 2022-10-31) with the S:P681R mutation found in the same time period, also in Austria. It could be possible that this lineage is a recombinant with the BF.7.9 sub-lineage.

This new lineage was spotted by a few virologists and independent researchers:

View: https://twitter.com/BorisUitham/status/1596467369563521024


View: https://twitter.com/LongDesertTrain/status/1596199893357379584


View: https://twitter.com/EllingUlrich/status/1596512388295294977


View: https://twitter.com/health_enjoyer/status/1594986999793975303


View: https://twitter.com/JosetteSchoenma/status/1596491305663594499


Researchers are keeping a close surveillance on this new lineage.

To date, COVID-19 infections are rising in Austria and interestingly in Vorarlberg, an increase in COVID-19 hospitalizations has been observed but there is no concrete evidence as to whether this new lineage is behind these or whether it is causing disease severity.

While the various Omicron variants and sub-lineages are still evolving rapidly and spawning more transmissible and immune evasive sub-lineages that are able to cause breakthrough infections and reinfections and create non-stop surges, they do not seem to contribute to immediate hospitalizations or increase in mortality except for those in the vulnerable groups (ie the aged, the young, the obese, the immunocompromised, those with existing comorbidities like diabetes hypertension, heart issues and kidney issues and also those with certain genetic defects.) However, as far as long COVID issues and other long term medical complications and also excess deaths, these new Omicron variants and sub-lineages are playing a very contributing role.



However, the public should be aware the many of the older variants such as even the original Wuhan strain, the alpha, beta, delta, gamma variants etc and their own novel sub-lineages are still in circulation and also are in certain human reservoirs including the immunocompromised and with the current kinetics of the COVID-19 pandemic and the relaxation of various measures, the prospect of recombinant or reassortant events or even such events taking place in animal reservoirs and then spreading back to humans via zoonotic transmissions is very likely. [...]
 

psychgirl

Has No Life - Lives on TB
They have rapid antibody tests? The only one I had heard about were around $80 at some lab in the back of walgreens or cvs. Do you know more about the rapid antibody test? Do you have more info? Thanks!
Kroger pharmacy here does both; rapid antibody and the send to the lab kind.
The rapid one I did last spring was 15$
Took 15 minutes maybe?

Central Indiana.
You just get an online appointment just like a Covid test
 

psychgirl

Has No Life - Lives on TB
(fair use applies)


Next major COVID variant IS poised to be more deadly, doctors warn after studying patient who harbored Omicron for six months
By Cassidy Morrison Senior Health Reporter For Dailymail.Com
Published: 13:06 EST, 28 November 2022 | Updated: 15:40 EST, 28 November 2022
  • South African researchers found that the Covid infection mutates over time
  • An HIV-infected patient saw cell death and fusion increase over six months
  • This indicates a new more dangerous variant could arise from milder omicron

The world's next major Covid variant is poised to be more severe than the mild strains that are currently world-dominant, according to a new study.

The ultra-infectious Omicron strain emerged almost exactly a year ago and its mutated spinoffs have risen to the top in virtually every country in the world.

They are far milder than the older versions of the virus and many researchers believed they represented a kind of end game for Covid’s evolution, which like many viruses before it, mutate to be more mild so they can spread more easily.

But researchers in South Africa say the virus still has the potential to get deadlier after examining an immunocompromised HIV patient who harbored the virus for half a year.

Over time, the virus evolved to cause more cell death and cell fusion, leading to increased inflammation in the lungs. These effects more closely resembled those of the ancestral Covid strain than the Omicron strain, according to Professor Alex Sigal, the virologist who led the study.

The patient studied is one of the longest known sufferers of Omicron, which itself is widely believed to have evolved in someone with a severely weakened immune system.

Immunocompromised people cannot adequately clear out infection, which allows the virus to continually replicate and mutate in their body over time, before spreading to others with its new alterations.

Still, the findings from South Africa represent just one theory about the future of Covid's spread and protection gained through vaccination and prior infection puts the US - and world - in a stronger position to beat back another deadly surge.

The finding comes amid warnings that China's unrelenting Covid outbreak could spawn a doomsday variant which has the potential to send the world back to square one in its fight against the virus.

China's draconian 'zero-Covid' policy has driven economic hardship and residents back into isolation. Cases have doubled within a fortnight across the country, where the pandemic began almost three years ago. A record 40,000 people are now testing positive every day, with millions subject to restrictions.

The omicron variant has proven to cause less severe disease than the original Covid strain as well as the alpha and delta variants.

The team’s findings do not bode well for the global response to the ongoing public health issue.
The latest study was carried out by researchers from the Africa Health Research Institute in the South African city of Durban, which was the first lab to test the original Omicron against the older vaccines and show that strain significantly weakened their effects.

Researchers looked at regular blood samples from the long-term Covid patient who was infected with Omicron.

They sequenced viral samples from the patients blood shortly after they were diagnosed with Covid, then within the first month of diagnosis, and then at three-month intervals.

They studied changes to the virus' genetic makeup, as well as how infected human cells behaved.

As time from first diagnoses went on, cell death became more frequent.

When the patient was first infected with Omicron, around four per cent of human cells that were infected died. That was about a third the level of the Wuhan strain that first emerged in late 2019, which killed about 12 per cent of infected cells.

At day six after diagnosis, less than six per cent of cells were detected as dead. By day 20, that rate increased to nearly seven per cent.

The frequency of cell death, which represented how severity of disease changed, spiked again to nearly 10 per cent at day 190, roughly the same rate as that of the original Wuhan strain.

Dr Sigal said: ‘It's not simple because early virus was attenuated. However, by parameters we measured, it became less attenuated, showing that long-term evolution does not always lead to attenuation.

‘Therefore, the next major variant, if it comes, may not necessarily be as mild as Omicron.’

Covid-19 disease leads to cell death, causing systeming inflammatory effects.

The finding came as a shock to the researchers, who hypothesized that strains of Covid-19 will become less virulent and infectious over time judging by the relative mildness of omicron compared to previous variants.

In China, the daily case rate began to shoot upwards one month ago and this weekend hit 39,791 — nine in 10 of which were asymptomatic, according to data from the National Health Commission. The more Covid is permitted to spread, the more it can replicate and mutate.

Dr Simon Clarke, a microbiologist based at the University of Reading, told MailOnline: 'Every single Covid infection presents the virus with an opportunity to change its characteristics.

'The idea that this only leads to decreased lethality is simply wrong; having effective population-wide immunity seems to have had a much more substantial protective effect, but compared to the vaccines used here it seems that China's is less effective, which might be contributing to their problem.

The US has been bracing for a surge in Covid during the winter months which, for the most part, has been overshadowed by the explosion of RSV and flu cases.

Patients in many states where hospitals are swamped are being transferred hundreds of miles in helicopters in search of an available bed.

Even major hospitals such as Mass General for Children in Boston and Baltimore’s Johns Hopkins are stretched thin.

But the latest pre-print publication - which has not been peer-reviewed by other scientists - came with several caveats.

The hypothesis was only testing a single patient. A much larger sample size is needed to make a conclusion about the virus’ course of evolution.

The manuscript, published last week, does not indicate that the US must revert back to blanket mitigation measures such as compulsory masking.

But it bolsters government warnings that the pandemic remains a major public health issue.

Dr Anthony Fauci, the government’s top infectious disease expert and President Joe Biden’s chief medical advisor said on Sunday that the US is ‘certainly’ still in the middle of a Covid pandemic.

‘I think the idea that forget it, this is over — it isn’t,’ he said.

More than 23,000 people on average are in the hospital for Covid every day while average daily deaths are hovering between 300 and 400.
I saw this story earlier today :(
 

Heliobas Disciple

TB Fanatic
(fair use applies)



VSS Scientific Updates During Pandemic Times #47
by Geert Vanden Bossche
December 2, 2022


1. China's COVID Infections Hit Record


“Wednesday's 31,444 new local COVID-19 infections broke a record set on April 13, when the commercial hub of Shanghai was crippled by a city-wide lockdown of its 25 million residents that would last two months.”


2. This Thanksgiving, Be Grateful The Turkey On Your Table Avoided Avian Flu

From Geert: “I continue to emphasize that in highly vaccinated countries Bird Flu may start to spread asymptomatically via vaccinees and that C-19 unvaccinated who vaccinate against seasonal/common Flu are at high risk of contracting Ab-dependent enhancement of avian Flu disease!”


3. Next Covid-19 Strain May be More Dangerous, Lab Study Shows

“A South African laboratory study using Covid-19 samples from an immunosupressed individual over six months showed that the virus evolved to become more pathogenic, indicating that a new variant could cause more illness than the current predominant omicron strain.”


4. Experimental Flu Vaccine, Developed Using mRNA, Seen as Potential Game Changer?

From Geert: “These non-talents do not realize that what they are considering ‘absolution of antigenic sin’ is nothing else than immune refocusing. The latter occurs upon vaccine breakthrough infection, which explains why these vaccines are not protective against productive infection and disease but only against severe disease and death! What these pseudo-vaccinologists don’t say (or don’t know?) is that ‘immune refocusing-enabling breakthrough infections’ only provide short-lived protection and drive immune escape. Hence, if implemented at large scale, these vaccines will eventually drive co-circulation of highly infectious variants (in the same way that we’re currently observing with Omicron descendants). I am predicting with 200 % certainty that co- circulation of highly infectious variants paves the way to enhanced viral virulence in vaccinees. These professors should study the immune epidemiology of viruses chased by mass vaccination rather than continuing the eternal cycle of empiricism which has been the biggest shortcoming in vaccinology all along!”


5. Observed vs Expected Rates of Myocarditis After SARS-CoV-2 Vaccination

“Although absolute rates of myocarditis were low, vaccine type, age and sex are important factors to consider when strategizing vaccine administration to reduce the risk of postvaccination myocarditis. Our findings support the preferential use of the BNT162b2 vaccine over the mRNA-1273 vaccine for people aged 18–29 years.”

 
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