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Many won’t rely on virtual options after COVID: AP-NORC poll
By HANNAH FINGERHUT and R.J. RICO
yesterday


WASHINGTON (AP) — Many Americans don’t expect to rely on the digital services that became commonplace during the pandemic after COVID-19 subsides, according to a new poll, even as many think it’s a good thing if those options remain available in the future.

Close to half or more of U.S. adults say they are not likely to attend virtual activities, receive virtual health care, have groceries delivered or use curbside pickup after the coronavirus pandemic is over, according to a poll from The Associated Press-NORC Center for Public Affairs Research. Less than 3 in 10 say they’re very likely to use any of those options at least some of the time.

Still, close to half also say it would be a good thing if virtual options for health care, for community events and for activities like fitness classes or religious services continue after the pandemic.

“Rather than this either-or, I think we’re more likely to be facing a hybrid future,” said Donna Hoffman, director of the Center for the Connected Consumer at the George Washington School of Business. “People have found convenience in some of these virtual options that just makes sense, and they don’t necessarily have anything to do with like keeping you safe or the pandemic even though they came of age during the pandemic.”

Digital daily routines became the default in 2020 as the nation reacted to the rapidly spreading virus, which prompted lockdowns, closed schools and shuttered businesses. Some substitutions, like online shopping and video conference calling, already existed. Others were reimagined or popularized during the pandemic.

Either way, Hoffman said, there was “rapid” deployment and adoption of virtual services. It was a question of “how are we going to make this work?” she said.

Cornelius Hairston said his family took precautions throughout the pandemic because his wife is a first responder in the health care field.

“We tried to stay in as much as we could and only come out for essentials,” said Hairston, 40, who recently moved to Roanoke, Virginia.

Hairston joked that his twin 4-year-old boys are “COVID babies” who didn’t even go to a grocery store for much of their young lives. The family used delivery services almost exclusively to avoid venturing out to crowded stores. But going forward, he only expects to use them “from time to time.”

For Angie Lowe, the convenience of telemedicine and time saved was reason enough to do it again even though she and her husband returned to doing things in public more than a year ago.

Lowe had her first telemedicine appointment early in the pandemic when feeling “lonely” and “stuck at home” kept her from sleeping well. She was able to talk with the doctor without having to take extra time off of work to drive to and wait in a medical center.

“It was my first telemedicine appointment, but it won’t be my last,” said Lowe, 48, of Sterling, Illinois. “If I can do it, I’m going to do it.”

For many, though, drawbacks outweigh the benefits of relying on digital services in the future. Adults age 50 or older are especially likely to say they are not planning to use the virtual options asked about on the poll going forward, even though many were introduced during the pandemic to protect the at-risk population.

Despite feeling antsy about COVID-19 and infection rates in Phoenix, Tony DiGiovane, 71, said he found curbside pickup at grocery stores and restaurants to be more hassle than they’re worth.

“By the time I picked up the stuff, I needed more stuff,” he said of his grocery orders, and “something’s always missing or wrong” on takeout orders.

Karen Stewart, 63, recognizes the benefits of video calls, but she’s also found them to be limiting. That’s the case in her job organizing after school programming for kids. She also now sees some of her doctors online, one who provides virtual care almost exclusively and another who uses virtual care in between office visits.

She likes that she doesn’t have to drive, but it means a doctor or nurse can’t take her vitals or be “hands on” in her care. It was “scary,” for example, when all of her appointments in the lead-up to a surgery were online, she said.

“When I do that they they can’t take my blood pressure, my pulse. There’s things that a doctor might pick up on that they can’t see online,” said Stewart of Perris, California.

The pandemic created an opportunity to balance in-person and virtual services to support the physical and mental health of older adults, said Alycia Bayne, a principal research scientist at NORC. That “could be particularly beneficial to older adults with different health issues, mobility limitations, people who lack transportation options, people who do not have or live near a robust social networks like family and friends to lean on,” she said.

Still, there remain limitations with technology access, broadband access and digital literacy, which Bayne said may help explain why the poll finds older adults less likely to use digital services after the pandemic.

Despite the age gap on use of services, similar percentages of adults across ages say it’s a good thing for virtual options for health care, for community events and meetings and for activities to continue after the pandemic.

“They recognize the benefits of virtual services, but they’re also ready to start getting back to their pre-pandemic routines,” she said. “The silver lining, of course, is that these services are now available.”

___
The poll of 1,001 adults was conducted May 12-16 using a sample drawn from NORC’s probability-based AmeriSpeak Panel, which is designed to be representative of the U.S. population. The margin of sampling error for all respondents is plus or minus 4 percentage points.
___
 

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Pediatric COVID-19 cases rising for 1st time since May
Last week, nearly 76,000 children tested positive for the virus.
ByArielle Mitropoulos
July 05, 2022, 5:57 PM

As more infectious COVID-19 variants become dominant in the U.S., there are renewed signs that COVID-19 cases may be back on the rise across parts of the country.

The national resurgence comes as the number of children testing positive for the virus also sees an increase again.
New infections among children had been on the decline since May, however, for the first time in nearly two months, there has been an uptick in the weekly total of pediatric COVID-19 cases.

Last week, nearly 76,000 children tested positive for the virus, up from the 63,000 pediatric cases reported the week prior, according to a new report from the American Academy of Pediatrics and the Children's Hospital Association.

Overall, totals remain significantly lower than during other parts of the pandemic. However, the organizations said that child cases are still "far higher" than one year ago, when just 12,100 cases were reported.

Many Americans, who are taking at-home tests, are also not submitting their results, and thus, experts said daily case totals are likely significantly higher than the numbers that are officially reported.

Approximately 13.8 million children have tested positive for the virus, since the onset of the pandemic. Approximately 5.9 million reported cases have been added so far this year. Children represent about a fifth of all reported cases on record.

COVID-19 related hospitalizations among children are also on the rise, with admission levels also reaching their highest point since February, federal data shows.

Late last month, all children, six months and older, became eligible for the COVID-19 vaccine — a welcome development in the fight against the pandemic that many parents had been eagerly awaiting.

Although it is still unknown how many children between the ages of six months and four years old have been vaccinated, data shows that the vaccine rollout in older children continues to lag.

Over 25 million children, over the age of five, who have been eligible for a shot since November, are still unvaccinated.

"It is critical that we protect our children and teens from the complications of severe COVID-19 disease," Centers for Disease Control and Prevention Director Dr. Rochelle Walensky said in a statement last month. "Vaccinating this age group can provide greater confidence to families that their children and adolescents participating in childcare, school, and other activities will have less risk for serious COVID-19 illness."

Despite continued encouragement from scientists and federal health officials, overall, less than half of children ages 5 to 17 — about 44.4% that age group — have been fully vaccinated.

An even small proportion — 38.6% — of children over 5, who are eligible for a booster, have received their supplemental shot.

The American Academy of Pediatrics and the Children's Hospital Association noted in their report that there is an "urgent" need to collect more age-specific data to assess the severity of illness related to new variants as well as potential longer-term effects.

"It is important to recognize there are immediate effects of the pandemic on children's health, but importantly we need to identify and address the long-lasting impacts on the physical, mental, and social well-being of this generation of children and youth," the organizations said.
 

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The Omicron BA.5 subvariant is now the dominant COVID-19 strain in the US, and it's driving a wave of summertime infections
Cheryl Teh - Business Insider
Wed, July 6, 2022, 1:29 AM
  • The Omicron BA.5 subvariant is now the dominant COVID-19 variant in the US.
  • New CDC estimates indicate that BA.5 accounted for around 54% of the infections recorded last week.
  • This comes amid a surge in case numbers and hospitalizations across the country this summer.
The Omicron BA.5 subvariant is now the dominant strain of COVID-19 plaguing the US, per new estimates from the Centers for Disease Control and Prevention.

The CDC released new estimates on Tuesday, which indicated that BA.5 made up 53.6% of the COVID-19 infections recorded last week. Meanwhile, BA.4, another contagious Omicron subvariant, accounted for 16.5% of the COVID-19 cases, meaning that these subvariants were recorded in just over 70% of the US's COVID-19 cases over the week ending July 2.

These numbers make BA.5 one of the primary drivers behind a recent summer spike in COVID-19 cases and hospitalizations.

According to The New York Times COVID-19 case tracker, new cases have hit a daily average of 105,754 as of July 4, an increase of 10% over the last 14 days. The Times' COVID-19 tracker also reported that hospitalizations have surged 12% to a daily average of 33,953 people, while intensive care admissions have risen 11% to a daily average of 3,793 cases over the last two weeks.

The Omicron subvariants BA. 4 and 5 are known to have mutations that allow them to evade the protection against the virus provided by taking a COVID-19 vaccine, or a prior infection.

The Food and Drug Administration, or FDA, announced on June 30 that it is looking to approve vaccine booster jabs specifically meant to shield recipients against the Omicron BA.4 and 5 subvariants and to get these jabs rolled out for the fall and winter seasons.

Peter Marks, the director of the FDA's Center for Biologics Evaluation and Research, said in a statement released on June 30 that the FDA was advising vaccine manufacturers to update their COVID-19 jabs and "add an Omicron BA.4/5 spike protein component to the current vaccine composition."

"As we move into the fall and winter, it is critical that we have safe and effective vaccine boosters that can provide protection against circulating and emerging variants to prevent the most severe consequences of COVID-19," Marks said.
Read the original article on Business Insider
 

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As Army National Guard COVID-19 vax mandate deadline expires, states push back to stem force losses
Florida Republican Gov. Ron DeSantis said last month the federal vaccine mandate for Guardsmen is one of the reasons he reestablished the Florida State Guard.
By Natalia Mittelstadt
Updated: July 5, 2022 - 11:45pm

As the Army National Guard prepares to force soldiers out of military service due to its COVID-19 vaccine mandate deadline, some states are pushing back to prevent the loss of Guardsmen.

The Army National Guard vaccine mandate deadline expired on Thursday, with more than 40,000 Guardsmen not yet fully vaccinated and about 14,000 of them saying they do not intend to receive the vaccine, according to NBC News. Another 7,000 have requested exemptions, many of them religious.

"Beginning July 1, 2022,members of the Army National Guard and U.S. Army Reserve who have refused the lawful DOD COVID-19 vaccination order without an approved or pending exemption may not participate in federally funded drills and training and will not receive pay or retirement credit," the Army said on Friday.

"Soldiers who refuse the vaccination order without an approved or pending exemption request are subject to adverse administrative actions, including flags, bars to service, and official reprimands. In the future, Soldiers who continue to refuse the vaccination order without an exemption may be subject to additional adverse administrative action, including separation.

"Unit commanders will be able to activate and pay Soldiers for limited administrative purposes, such as receiving the vaccine, processing their exemption requests, or conducting separation procedures. Soldiers will be paid and/or receive retirement credit for these service days."

Guardsmen will also still be paid by their states when they are on missions from their state governors, CBS News reported.
The Army said that as of Friday, 89% of its National Guard received one dose of the COVID vaccine and 87% are fully vaccinated.

In Florida, prior to the vaccine mandate deadline, the state already had one of the most understaffed National Guards in the nation, with about 12,000 troops, or one guard member per 1,750 Floridians.

Florida Republican Gov. Ron DeSantis said last month the federal vaccine mandate for Guardsmen is one of the reasons he reestablished the Florida State Guard.

"The U.S. military has been kicking out great service members over the Biden administration's unacceptable COVID vaccine mandate, and they are even targeting members of the National Guard," DeSantis said. "The bureaucrats in D.C. who control our National Guard have also refused to increase the number of guardsmen despite our increasing population, leaving Florida with the second worst National Guardsman to resident ratio. By reestablishing the Florida State Guard under the leadership of Lieutenant Colonel Graham, we have a great opportunity to expand our capability to help people in times of need or disaster."

More than 1,200 people have applied for the Florida State Guard's 400 open positions.

The governors of Alaska, Iowa, Mississippi, Nebraska, Oklahoma, Texas, Virginia, and Wyoming have asked the Department of Defense not to enforce the vaccine mandate, according to Stars and Stripes.

Both Oklahoma and Texas have separately sued the federal government over the vaccine mandate for the National Guard, but they were denied preliminary injunctions against the enforcement of the mandate. Alaska also joined Texas' lawsuit.

Alabama Gov. Kay Ivey (R) sent a letter to President Joe Biden asking him to at least pause the mandate, although she believes it should be rescinded, according to the Alabama Political Reporter.

"More than 300 religious exemption requests have been submitted by members of the Alabama Army and Air National Guard, and to date, none have received a final determination," Ivey wrote. "As it stands, these men and women are on track to face consequences with no accountability from the policymakers."

While about 80% of the roughly 12,000 members of the Alabama National Guard are vaccinated, "it stands to lose at least 300 soldiers and up to 1,000 soldiers should this policy proceed," according to Ivey.

Minnesota's National Guard said on Thursday that more than 500 of its 13,000 soldiers are not vaccinated. New Jersey's National Guard said that 88 of its members (13%) are not vaccinated.

Virginia Republican Gov. Glenn Youngkin, along with several Republican members of Congress, wrote to Defense Secretary Lloyd Austin to indefinitely delay the vaccine mandate, ABC local affiliate WVEC reported.

"A select number of [National Guard members] have made a decision not to get vaccinated and whether that decision is based on sincerely held religious beliefs, their own medical choices, or another matter of conscience, our nation should respect and accommodate it," the letter reads.

The elected officials said the mandate is not "consistent with the latest science" and has an impact on the readiness of the Virginia National Guard.

Sen. Marsha Blackburn (R-Tenn.) has introduced legislation that would prevent federal funds from being "used to require a member of the National Guard to receive a vaccination against COVID-19."

In the Army, a total of 1,037 soldiers have been separated from the military for refusing the COVID vaccine since the mandate deadline for active-duty members expired on Dec. 15. The soldiers were released from the military in a year when all branches are having difficulty meeting their recruiting goals for the year, NBC News reported.
 

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Authors Correct Study That Inflated Child COVID-19 Deaths After CDC Officials Promoted It
By Zachary Stieber
July 5, 2022

A study that inflated the number of COVID-19 deaths among children has been corrected after being promoted by top officials at the U.S. Centers for Disease Control and Prevention (CDC).

The paper falsely stated that at least 1,433 deaths primarily attributed to COVID-19 had occurred among those 19 and younger in the United States, but the actual number is 1,088, the authors acknowledged in the updated version (pdf).

The authors, led by British scientist Seth Flaxman, incorrectly utilized data from the CDC’s National Center for Health Statistics for the initial version. They said that they only included deaths where COVID-19 was considered the underlying, or primary, cause. But they actually also counted deaths where COVID-19 was listed as a contributing cause.

The initial version “incorrectly used these data,” the authors said in the updated paper.

Flaxman did not respond to a request for comment. Emails reviewed by The Epoch Times showed he did not understand how to use the CDC database that lists COVID-19 deaths before being told how to use it following publication of the study.

The other authors, all but one of whom are based outside of the United States, have not publicly commented on the correction.

In this image from video, Dr. Katherine Fleming-Dutra of the Centers for Disease Control and Prevention presents to the Food and Drug Administration’s Vaccines and Related Biological Products Advisory Committee during a virtual meeting on June 14, 2022. (FDA via The Epoch Times)

Three CDC Officials Promoted Study

The paper, which has still not been peer-reviewed, was cited by three CDC officials—including the agency’s director, Dr. Rochelle Walensky—while promoting COVID-19 vaccination for children under 5 years old in meetings and a press briefing in June.

“During March 2020 through April 2022, COVID-19 was among the top five leading causes of death in every age group of children under the age of 19 and the number one infectious cause of death in children,” Walensky said during a briefing, putting forth the same figures as outlined in the study.

But multiple issues with the research were identified by outside observers. The most important problem was including deaths were COVID-19 was not listed as the primary cause. Another was listing cumulative COVID-19 deaths against the annualized 2019 deaths of other causes, such as “accidents.”

CDC officials Dr. Katherine Fleming-Dutra and Dr. Sara Oliver cited the paper in talks with the agency’s vaccine advisory panel and experts who advise the Food and Drug Administration on vaccines. Dr. Matthew Daley, who chairs the CDC panel’s COVID-19 vaccines work group, also referenced it.

The PowerPoint slides that the officials showed during the meetings while citing the paper were disseminated widely on social media by outside officials like Dr. Nirav Shah, the director of the Maine CDC, in asserting that COVID-19 vaccines are necessary for children.

The CDC, Walensky, Fleming-Dutra, Oliver, and Daley have not responded to queries and have not alerted the public to the corrected paper.

Kelley Krohnert, a citizen researcher and mother who flagged the issues and alerted Flaxman to them, told The Epoch Times that the refusal to address the corrected data is part of a pattern from the CDC during the pandemic.
“It would be nice if somewhere they would acknowledge and accept responsibility for alarming parents with a statistic that turns out is completely bogus,” Krohnert said.

Epoch Times Photo Change in Results

The initial paper covered deaths recorded between March 2020 and April 2022.

The data highlighted by the CDC officials was already wrong because they used the cumulative number of deaths linked to COVID-19 in comparison with annualized figures for other causes of death, such as heart diseases and assault.

That slant put COVID-19 as a top five cause of death for all children.

Annualizing the COVID-19 deaths and comparing them to other annualized figures, COVID-19 ranked lower.

For instance, instead of being the fourth leading cause of death for children under one year old, it was the ninth leading cause of death for that age group.

In the updated version, researchers left out the cumulative numbers. They took the death data for the 12 months starting on April 1, 2022, and compared the numbers with other causes of death from the year 2019.

Accidents, suicide, and malignant neoplasms were among the issues that caused more deaths than COVID-19, the researchers found. COVID-19 was listed as the eighth leading cause of death for 0- to 19-year-olds during the time studied. According to the death certificate data, just 764 deaths were linked to the disease.

The authors maintained that the threat COVID-19 poses to children means that kids should get COVID-19 vaccines and pharmaceutical treatments and “mitigations such as ventilation” should be used. In the earlier version, they said their findings “underscore the importance of continued vaccination campaigns for children ≥5 years in the US and for effective Covid-19 vaccines for under 5 year olds.”
 

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Disney Employees Suing Company Over Vaccine Exemption Refusals
By Jackson Elliott
July 5, 2022

The Walt Disney Company punished and then fired three longtime employees because they refused the COVID-19 vaccine on religious grounds, according to a new lawsuit against the company.

On July 30, 2021, Disney announced that its employees would have to take one of the several COVID-19 vaccines to continue working with the company.

When Florida’s government forbade “vaccinate or terminate” policies, the company began a relentless push to vaccinate all employees, including those who had requested religious exemptions, the lawsuit states.

According to the plaintiffs, Disney burdened religious vaccine objectors with restrictions that went beyond its original pandemic policy.

“The mask, face shield, and distancing from cast and guest were clearly punitive measures designed to destroy my health, segregate me, harass, discriminate, and intimidate me into taking an experimental vaccine,” said Adam Pajer, one of the suing employees.

Religious Objections

Pajer, Barbara Andreas, and Stephen Cribb were longtime Disney employees.

Pajer worked at Disney for seven years and had some leadership responsibilities.

Andreas had worked there for 21 years and in leadership for 17 years.

Cribb was at the company for 11 years and received the Walt Disney Legacy Award, its highest award for park employees.
All refused to take a COVID-19 vaccine, citing religious objections.

Pajer said he believed he had a religious obligation not to harm his body and that the vaccine was harmful; Andreas objected to covering her face and the contamination of her blood by vaccine ingredients for religious reasons; and Cribb objected because he believed the Jansen, Moderna, and Pfizer vaccines were made using cells from aborted babies.

But instead of accepting these exemption requests, Disney pushed back. All three found the company was slow to respond to their requests, leaving them wondering about the position of their jobs.

When Disney finally responded, the employees faced interrogative interviews.

“[A Disney employee] proposed hypothetical questions to Ms Andreas, such as whether she would consent to a vaccine that did not contain aborted fetal cells. Ms Andreas was very uncomfortable about such an inappropriate line of questioning regarding her sincere religious beliefs,” the lawsuit reads.

Cribb said management asked him to abandon his religious convictions on the vaccine because the FDA approved it.

Pajer said managers yelled at him and lit a written statement about the discrimination he faced while he was still holding it.

Eventually, Disney denied religious exemptions to all three employees. It also refused to speak with their lawyers.

In Cribb’s case, “Counsel requested that Disney direct correspondence directly to him, and Disney flatly refused,” the lawsuit said.

Employees who refused to take the vaccine faced a series of restrictive safety measures that they argued amounted to coercion.

The unvaccinated employees said they had to wear masks while outside, wear N95 masks with “Warning” written on the front, eat in segregated areas, and not take off their masks even for a moment.

The company called for intrusive measures to test whether masks worked too. A technician sprayed a mist in employees’ faces, according to the employees’ lawyer.

Employees said that wearing a mask outside all day is stuffy and grueling in Florida’s intense heat. But Disney management showed little mercy.

Targets for Bullying

“I was accused of pulling a mask away from my face just to catch my breath after being forced to wear it for the entirety of my shift, inside and outside, when other cast had the choice not to wear them at all,” said Pajer.

Disney didn’t provide separate areas where unvaccinated employees could get lunch.

At the same time, Disney had ended outdoor mask mandates for unvaccinated guests.

The lawsuit said that pictures and videos during a 2022 outdoor Mardi Gras event showed that Cribb was likely the only person among hundreds of employees and guests at the resort wearing a mask.

“He was overwhelmed by the humiliation of Disney’s overt discrimination,” the lawsuit reads.

According to Andreas, these measures singled out unvaccinated employees and made them targets for a bullying campaign.

Epoch Times Photo Even after Disney allowed guests in without unmasked and unvaccinated, staff faced continued COVID-19 restrictions.

“We became the subject of harassment by other cast members and guests once the PPE provided a visual display of our private information,” she said.

The lawsuit said that these restrictions resembled what Disney demanded of COVID-19-exposed staff before the vaccines became available.

“The augmented protocols now suddenly enforced on plaintiffs consisted of harsh isolation and restrictions, causing serious breathing problems for plaintiffs, and making it nearly impossible to find a compliant manner and location in which to eat or drink while on shift,” the lawsuit reads.

Fired for Faith

Finally, Disney fired all three employees for refusing to take the vaccine.

“My dream-come-true became a total nightmare,” said Cribb.

“Suddenly, the same organization that had captivated my imagination in childhood with its one-of-a-kind magical appeal revealed its true self—a corporate machine bent on pursuing financial and political ends at any cost.”

The three employees filed a joint lawsuit against Disney for taking retaliatory action because employees filed religious discrimination claims.

The trio asked the court to reinstate their employment, end Disney’s enforcement of discriminatory protocols, and pay each plaintiff back for lost wages, lost benefits, attorney fees, and any other required relief.

“Disney is not above the law. Their actions in the past month have shown the public that Christians have no place in their parks or on their payroll,” said Andreas.
 

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US Marines Ask Court for Relief From COVID-19 Vaccine Mandate
By Jack Phillips
July 5, 2022

Several members of the U.S. Marine Corps filed an amended complaint seeking relief from the Department of Defense’s COVID-19 vaccine mandate for service members, claiming they were denied religious exemptions.

The complaint was filed (pdf) in the U.S. District Court Middle District of Florida against the Defense Department, Secretary Lloyd Austin, and Gen. David H. Berger, the head of the Marine Corps.

“The plaintiffs are Marines who face a deadline to receive an injection that violates their sincerely held religious beliefs since all of the COVID shots are associated with aborted fetal cells,” said a news release from Liberty Counsel, which filed the claim on 15 Marines’ behalf.

Those Marines, the release added, “have been refused any religious exemption or accommodation,” although the deadline to receive the vaccine has long passed. “These dates have passed, and disciplinary actions have already commenced,” it said.

Now, the Marines are seeking relief to prevent them from facing court-martials, dishonorable discharges, or other demeaning measures, according to the group.

“As we prepare to celebrate Independence Day, we must continue to fight for the freedom of those who protect us every day. No service member should be forced to choose between serving God and serving country,” Liberty Counsel Founder and Chairman Mat Staver said in a statement. “The Department of Defense continues to violate the law and ignore their religious freedom. This lawlessness must end.”

Since the Defense Department handed down the COVID-19 vaccine mandate for service members in August last year, numerous lawsuits have been filed. Two months ago, for example, a former Marine Corps captain filed a suit in the Eastern District of Texas and alleged the mandate is unlawful.

“The heart of the claim is that these are not vaccines,” former Marine Corps Capt. Dale Saran told The Epoch Times in late May about the suit. “They don’t have any live virus in them; the only thing that makes them even remotely related to a vaccine is the route of administration—a shot through a needle.”

And in March, U.S. District Judge Reed O’Connor blocked the military’s vaccine mandate for all Navy members who were seeking religious exemptions to the shot.

“Each is subject to the Navy’s COVID-19 vaccine mandates. Each has submitted her religious accommodation request, and none has received accommodation,” according to his order. “Without relief, each servicemember faces the threat of discharge and the consequences that accompany it. Even though their personal circumstances may factually differ in small ways, the threat is the same—get the jab or lose your job.”

That ruling came days before the U.S. Supreme Court sided with the Pentagon in that case, temporarily granting the department’s request to allow top Navy officials to consider a Navy service member’s vaccination status on deciding whether they should be deployed.

The Epoch Times has contacted the Department of Defense for comment on the Liberty Counsel-backed complaint.
 

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Quarantining Measures Continue as COVID-19 Hits Chinese City Northwest of Shanghai
By Sophia Lam
July 5, 2022

Quarantining measures have continued for many residents of the Chinese city of Wuxi amidst an outbreak of COVID-19.
Wuxi, a city of 7.5 million residents and 80 miles northwest of Shanghai, is an important commercial and trade hub of Jiangsu Province.

According to official city announcements, this wave of the pandemic outbreak began on June 25, when two people from Anhui Province tested positive for COVID-19, and they spread the disease to colleagues at a construction site in Wuxi.

As of July 4, a total of 145 people have tested positive for COVID-19, and 24 locations have been designated high-risk areas, in which local residents are confined strictly to their households, a Wuxi municipal notice reads.

Public transport routes have been rescheduled, underground shops and gyms, and scenic spots are closed, according to the Wuxi municipal government’s notice on July 3.

Ms. Li (a pseudonym) told the Chinese language edition of The Epoch Times on July 3 that her community is not among the high-risk areas.

“At the moment, we can enter our compound as long as we have a negative PCR test report, but it is difficult for us to go out,” she said. “It’s hard to say what it will be like later.”

The city’s largest leather products shopping mall—Wuxin Leather City, which has a floor space of 30 hectares, has also been closed under the regime’s draconian zero-COVID policies. Those who work, as well as family members, in the leather mall and three other major shopping malls in the neighborhood are being taken to isolation venues in two cities close to Wuxi.

‘20,000 People’ in Isolation Centers

Multiple video clips show Wuxi residents queuing up for buses to isolation centers. They are all dressed up in personal protection gear in the hot summer, carrying luggage with them. Young children can be seen among the crowds.

Wuxi’s Yunlin neighborhood committee’s pandemic prevention and control command has reportedly ordered residents to prepare clothing, daily necessities, and necessary medication that can last them seven days in isolation.

The Epoch Times cannot verify the authenticity of the video clip or the online notice.

Qi Yu (using an alias for safety reasons) confirmed to the Chinese language edition of The Epoch Times on July 3 that the leather products shopping mall had been shut down and they have been transported to different quarantine hotels.

“The shopping mall is closed, and we have all been isolated to hotels,” Qi said, “There are over 20,000 of us, including the business owners in the mall and our families.”

He said that he has no idea how many of them have tested positive for COVID-19.

The Epoch Times reached out to Wuxi’s health commission, pandemic prevention and control center, and the municipal government on July 4, but the hotlines and numbers were either not answered or could not get through.

The Chinese regime’s zero-COVID policies have created severe hardships for many Chinese people affected by them and sparked concerns about China’s economic growth in 2022. Economists worldwide recently lowered their forecasts for China’s expected GDP growth in 2022.

Hong Ning contributed to the article.
 

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One Day After White House Signs $3.2 Billion Pfizer Deal, FDA Says Fall COVID Boosters Must Target Omicron Subvariants
The U.S. Food and Drug Administration said COVID-19 vaccine manufacturers will need to update fall boosters to target BA.4 and BA.5 Omicron subvariants, a day after the White House announced a $3.2 billion vaccine deal with Pfizer to include new boosters for subvariants.
By Megan Redshaw
07/05/22

The U.S. Food and Drug Administration (FDA) advised COVID-19 vaccine manufacturers on June 30 that any modifications to booster shots for fall will need to target Omicron subvariants BA.4 and BA.5, which account for more than half of new virus cases in the U.S.

Original vaccines based on the Wuhan strain that is no longer circulating will be used for anyone getting their primary series of shots.

The FDA’s announcement came a day after the Biden administration said it had already entered into a $3.2 billion deal with Pfizer to purchase 105 million doses of its COVID-19 vaccine for a fall vaccination campaign. The announcement said these vaccines will include supplies of new unauthorized bivalent boosters containing the original Wuhan variant and BA.4 and BA.5 Omicron subvariants.

In a press release, Dr. Peter Marks, director of the FDA’s Center for Biologics Evaluation and Research, said manufacturers seeking to update current COVID-19 vaccines were advised they should “develop modified vaccines that add an omicron BA.4/5 spike protein component to the current vaccine composition to create a two-component (bivalent) booster vaccine so that the modified vaccines can potentially be used starting in early to mid-fall 2022.”

Vaccine manufacturers already reported data from clinical trials using Omicron BA.1 but will have to submit their data to the FDA prior to its evaluation of any potential authorization of a modified vaccine containing the omicron BA.4 and BA.5 components.

Although there have been no clinical trials to date testing modified vaccines with Omicron subvariants in humans, Marks said manufacturers “will also be asked to begin clinical trials with modified vaccines containing an omicron BA.4/5 component, as these data will be of use as the pandemic further evolves.”

Marks said Pfizer-BioNTech and Moderna were not asked to change the formulation for initial doses of their COVID-19 vaccines, since the current formula “provides a base of protection against serious outcomes.”

Instead, the agency expects this coming year to be a “transitional period when a modified booster vaccine may be introduced,” he added.

Pfizer and Moderna are expected to accept the FDA’s recommendation to modify their booster vaccines and will start producing the reformulated doses this summer for a fall rollout if federal regulators authorize the new booster campaign, The New York Times reported.

Dr. Ofer Levy, director of the precision vaccines program at Boston Children’s Hospital and an adviser to the FDA, said he supported the FDA’s recommendation.

“FDA is in a tough spot,” Levy said. “While regulators could benefit from more data, we also have to make a damn decision here because the fall is coming.”

FDA officials have said that in order to have a modified booster ready by fall, the design of the vaccine would have to be selected by early summer, as manufacturers need a three-month lead time.

Pfizer said its modified booster targeting Omicron subvariants could be ready for use in early October, while Moderna has projected availability by late October or early November.

Biden administration announces multi-billion-dollar deal with Pfizer one day after FDA advisors meet

The U.S. Department of Health and Human Services (HHS) on June 29 announced it had made an advance purchase of 105 million doses of Pfizer-BioNTech’s vaccine for $3.2 billion, with options to buy up to 300 million doses.

The White House has dropped all pretense that this is about protecting public health. This is an unsheathed, corporate welfare project to further enrich the shareholders of the most profitable industry in history.$3.2 Billon Taxpayer-Funded Deal With Pfizer Will ‘Enrich Shareholders of Most Profitable Industry in History’
— Robert F. Kennedy Jr (@RobertKennedyJr) July 5, 2022

The Biden administration used repurposed money to buy the additional vaccines, “betting on a next generation of boosters without knowing who might need one or how they will perform.”

According to The New York Times, Xavier Becerra, HHS health secretary, called the contract “an important first step to preparing us for the fall.”

The contract includes a combination of adult and pediatric doses, and supplies of re-formulated booster doses that will contain the original Wuhan variant and BA.4 and BA.5 Omicron subvariants.

The announcement was made one day after the FDA’s Vaccines and Related Biological Products Advisory Committee (VRBPAC) voted 19 to 2 to recommend future COVID-19 booster doses be modified to include an Omicron component, and before the FDA’s announced it had made recommendations to vaccine makers that their boosters should target Omicron subvariants.

“The White House has abandoned all pretense that either science or public health concerns motivate national COVID policies,” Robert F. Kennedy Jr., lead counsel and chairmen of Children’s Health Defense, told The Defender. “The American regulatory apparatus is now a naked appendage of Pfizer”s marketing department.”

Dr. David Gortler, a pharmacologist, pharmacist, FDA and healthcare policy oversight fellow, and FDA reform advocate at the Ethics and Public Policy Center in Washington, D.C., said in an email to The Defender:

“Nobody is taking the booster shots and the White House just keeps ordering them and ordering them from Pfizer — and Pfizer is on track to make $50 billion off vaccines in 2022 alone and the government keeps on ordering.

“The White House has already paid $5.3 billion and has committed to an additional $5.3 billion to Pfizer for Paxlovid. Pfizer is additionally making billions every month producing a vaccine/booster that nobody wants to take because they have seen data over the past 18 months that it is not only ineffective but unsafe according to VAERS.

“Our former FDA commissioner [Dr. Scott Gottleib] is on the board of Pfizer and had until very recently been unrelentingly promoting vaccination and boosters nonstop along with Fauci, Biden, CDC [Centers for Disease Control and Prevention] and the FDA. Pfizer itself has determined that Paxlovid doesn’t work and has already ceased enrollment in its EPIC-SR Paxlovid clinical trial.

“Everybody knows that viruses mutate, and promoting 2019 vaccine ‘boosters’ for a 2022 mutated, less virulent and non-deadly virus is asinine,” Gortler added. “I’m concerned that there might be some unseemly or unholy relationship going on between the FDA, Pfizer and the White House because continuing to purchase more boosters and primary series on infants and kids certainly doesn’t make any sense biologically, immunologically or pharmacologically to anyone paying attention.”

During VRBPAC’s June 28 meeting, advisors did not vote on whether additional data would be needed to recommend an updated composition of the primary-series vaccines authorized for emergency use in the U.S., or whether it would be appropriate to continue to use a primary-series vaccine as a booster.

The panel also did not decide whether shots should target the Omicron BA.1 variant or BA.4 and BA.5 subvariants, leaving the decision up to the FDA.

VRBPAC said at the close of the meeting it would provide guidance the FDA could consider when making recommendations on future COVID-19 boosters doses.

It is unknown whether any guidance was provided by VRBPAC or reviewed by the FDA before it advised vaccine makers to update boosters to target Omicron subvariants — boosters Pfizer had already contracted to produce for the Biden administration.
 

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Pfizer Asks Court to Dismiss Whistleblower Lawsuit Because Government Was Aware of Fraud
In an interview with The Defender, the lawyer representing whistleblower Brook Jackson said Pfizer is arguing the court should dismiss Jackson’s lawsuit alleging fraud in Pfizer’s COVID-19 clinical trials because the U.S. government knew about the wrongdoings but continued to do business with the vaccine maker.
By Michael Nevradakis, Ph.D.
07/05/22

A lawsuit filed by whistleblower Brook Jackson alleging Pfizer and two of its contractors manipulated data and committed other acts of fraud during Pfizer’s COVID-19 clinical trials is paused following a motion by the defendants to dismiss the case.

In an interview with The Defender, Jackson’s lawyer said Pfizer argued the lawsuit, which was filed under the False Claims Act, should be dismissed because the U.S. government knew of the wrongdoings in the clinical trials but continued to do business with the vaccine maker.

Under the False Claims Act, whistleblowers can be rewarded for confidentially disclosing fraud that results in a financial loss to the federal government.

However, a 2016 U.S. Supreme Court decision that expanded the scope of a legal principle known as “materiality” resulted in a series of federal court decisions in which fraud cases brought under the False Claims Act were dismissed.

As interpreted by the Supreme Court, if the government continued paying a contractor despite the contractor’s fraudulent activity, the fraud was not considered “material” to the contract.

Pfizer is a federal contractor because it signed multiple contracts with the U.S. government to provide COVID-19 vaccines and Paxlovid, a pill used to treat the virus.

“Pfizer claims they can get away with fraud as long as the government would write them a check despite knowing about the fraud,” attorney Robert Barnes said.

The other two defendants in the case are Ventavia Research Group, which conducted vaccine trials on behalf of Pfizer, and ICON PLC, also a Pfizer contractor.

In an attempt to strengthen the False Claims Act’s anti-retaliation provisions and install new safeguards against industry-level blacklisting of whistleblowers seeking employment, Congress in July 2021 introduced the False Claims Amendments Act of 2021.

In December 2021, Pfizer hired a well-connected lobbyist, Hazen Marshall, and the law firm Williams & Jensen to lobby against the bill.

Pfizer previously was heavily fined in connection with the False Claims Act. As part of a 2009 settlement, the company paid $2.3 billion in fines — the largest healthcare fraud settlement in the history of the U.S. Department of Justice — stemming from allegations of illegal marketing of off-label products not approved by the U.S. Food and Drug Administration (FDA).

“Pfizer, one of the most criminally fined drug companies in the world, wants to weaken the laws that hold them accountable,” Barnes told The Defender.

Congress has taken no action on the False Claims Amendments Act since November 2021, when the bill was added to the Senate’s legislative calendar.

Barnes said the outcome of Jackson’s case against Pfizer is significant not just for his client, but also for the American public.

“This case will determine if Big Pharma can rip off the American people using a dangerous drug that harms millions without any legal remedy because they claim the government was in on the scam.”

Jackson was a regional director for Ventavia for a brief period in 2020 but was fired after she notified the FDA about issues with Pfizer’s vaccine trials.

After she was fired, she gave The BMJ a cache of internal company documents, photos and recordings highlighting the alleged wrongdoing by Ventavia.

The documents she provided contained evidence of falsified data, blind trial failures and awareness on the part of at least one Ventavia executive that members of the company’s staff were “falsifying data.”

Jackson’s documents also provided evidence of administrators who had “no training” or medical certifications, or who provided “very little oversight” during the trials.

Jackson filed her complaint in August 2021, in the U.S. District Court, Eastern District of Texas, Beaumont Division, alleging Pfizer, Ventavia and ICON “deliberately withheld crucial information from the United States that calls the safety and efficacy of their vaccine into question.”

A district court judge in February unsealed Jackson’s complaint, which included 400 pages of exhibits.

According to the complaint, Jackson, who had more than 15 years of experience working with clinical trials, “repeatedly informed her superiors of poor laboratory management, patient safety concerns and data integrity issues” during the approximately two weeks she was employed by Ventavia.

“Brook [Jackson] brought a Qui Tam action and a retaliatory discharge case against Pfizer and others for fraud on the people concerning Pfizer’s false certifications to the U.S. Department of Defense about the safety and efficacy of their COVID-19 vaccine,” Barnes said.

A Qui Tam case refers to a provision under the False Claims Act that allows individuals and entities with evidence of fraud against federal programs or contracts to sue the wrongdoer on behalf of the U.S. government

“She was part of the clinical trials, witnessed extraordinary malfeasance, blew the whistle, and was quickly fired after she blew the whistle.”

Barnes said his legal team will in August file its opposition brief to Pfizer’s motion to dismiss, and the judge may rule on the motion to dismiss by fall 2022.
 

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‘Why the Rush for Toddler Vaccines?’ Asks Wall Street Journal Editorial Board Member
Allysia Finley, a member of Wall Street Journal’s editorial board, Monday called into question the motives behind the U.S. Food and Drug Administration’s decision to extend emergency use of Pfizer and Moderna’s COVID-19 vaccines to infants and toddlers.
By Susan C. Olmstead
07/05/22

A Wall Street Journal (WSJ) editorial board member Monday called into question the motives behind the U.S. Food and Drug Administration’s (FDA) decision to extend Emergency Use Authorization of Pfizer and Moderna’s COVID-19 vaccines to toddlers and infants as young as 6 months old, writing that the decision was motivated by politics and pressure rather than science.

In her WSJ opinion piece — “Why the Rush for Toddler Vaccines?” — Allysia Finley wrote:

“The FDA standard for approving vaccines in otherwise healthy people, especially children, is supposed to be higher than for drugs that treat the sick.

“But the FDA conspicuously lowered its standards to approve COVID vaccines for toddlers. Why?”

Finley started her piece with a quote from President Biden, which praised the FDA’s recommendation: “This is a very historic milestone. The United States is now the first country in the world to offer safe and effective COVID-19 vaccines for children as young as six months old.”

She responded, writing, “In fact, we don’t know if the vaccines are safe and effective.”

She continued:

“The rushed FDA action was based on extremely weak evidence. It’s one thing to show regulatory flexibility during an emergency. But for children, Covid isn’t an emergency.

“The FDA bent its standards to an unusual degree and brushed aside troubling evidence that warrants more investigation.”

“Mr. Biden’s hypocrisy is hard to stomach,” she wrote, listing many reasons for caution in vaccinating young children against COVID-19, including:
  • Children are at low risk of dying from COVID-19: Only 209 kids between 6 months and 4 years old have died from COVID-19 — about 0.02% of all virus deaths in the U.S. About half as many toddlers were hospitalized with COVID-19 between October 2020 and September 2021 as were hospitalized with the flu during the previous winter.
  • The two children in Pfizer’s trial who got sickest with COVID-19 also tested positive for other viruses. It’s possible that many hospitalizations attributed to COVID-19 this winter were instigated or exacerbated by other viruses.
  • The FDA authorized vaccines for toddlers based on a comparison of the antibodies they generated to the original Wuhan variant with those in young adults who had received two doses. But two doses offer little if any protection against Omicron infection in adults, and even protection against hospitalization is only around 40% to 60%.
  • Vaccinated toddlers in Pfizer’s trial were more likely to get severely ill with COVID-19 than those who received a placebo. Most children who developed multiple infections during the trial were vaccinated.
“FDA granted the Pfizer and Moderna vaccines for toddlers an emergency-use authorization allowing the agency to expedite access for products that ‘prevent serious or life-threatening diseases or conditions,’” wrote Finley.

“While adult COVID vaccines clearly met this standard in late 2020, the toddler vaccines don’t.”
As to why the FDA “rushed” and “bent its standards,” Finley suggested, “perhaps [the FDA] felt pressure from the White House as well as anxious parents.”

White House COVID-19 response coordinator Ashish Jha repeatedly told parents that he expected vaccines for toddlers would be available in June, she wrote.

The views and opinions expressed in this article are those of the authors and do not necessarily reflect the views of Children's Health Defense.
 

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Chinese City of 13 Million Shuts Down Again to Avoid COVID 'Explosion'
Agence France-Presse
July 05, 2022 11:45 AM

Businesses, schools and restaurants in Xi'an will close for one week, officials said Tuesday, after the Chinese city logged a handful of COVID-19 cases as outbreaks nationwide strain Beijing's zero-tolerance virus approach.

China is the last major economy wedded to a zero-COVID strategy, deploying snap lockdowns, quarantines and travel curbs in a bid to weed out new infections.

Xi'an — a historic city of 13 million that endured a month-long lockdown at the end of last year — has reported 18 cases since Saturday in a cluster driven by the fast-spreading Omicron variant, according to official notices.

City official Zhang Xuedong said at a Tuesday press conference that Xi'an would implement "seven-day temporary control measures" that would "allow society to quieten down as much as possible, reduce mobility... and cut the risk of cross-infection".

"We must race against both time and the virus... to guard against all possible risks and hidden dangers, and decisively avoid an explosion in community spreading," Zhang said.

Public entertainment venues including pubs, internet cafes and karaoke bars would shut their doors from midnight on Wednesday, the city government said in a notice.

Restaurants will not be allowed to serve diners indoors but may continue to offer takeaway services, it said.

Schools are to start the summer holiday early and universities will seal off their campuses.

Xi'an — home to the Terracotta Warriors — previously experienced one of China's longest stay-at-home orders, shutting off for a month between December and January as thousands of COVID cases were detected.

City authorities came under fire for their handling of the lockdown, which was plagued by food supply issues and medical tragedies stemming from patients being denied access to hospitals.

Some residents in the tourist city expressed dismay at the closures on social media Tuesday.

"It's like they're addicted to lockdowns. What else do they even do?" wrote one on the Twitter-like Weibo platform.

"Here we go again," complained another.

China logged 335 new domestic cases on Tuesday, most of which were asymptomatic, according to the National Health Commission (NHC).

China's latest significant flare-up is in central Anhui province, where 1.7 million people in two counties were under orders to stay at home as of Tuesday.

Around 90% of the nearly 300 infections reported in the province on Monday were asymptomatic, according to the NHC. Over 1,000 cases have been detected during the outbreak so far.

Separately, city officials in Shanghai have launched a new round of mandatory COVID testing in most districts after "successively recording many local positive cases" since Sunday.

Many of the commercial hub's 25 million people will have to take two tests between Tuesday and Thursday, authorities said.

Despite a grueling, two-month citywide lockdown being formally lifted at the end of May, parts of Shanghai have simmered under local lockdowns and testing drives after finding sporadic new cases.
 

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BA.5 causes more severe disease
19 min 19 sec
Jul 5, 2022
Dr. John Campbell

UK infections continue upwards https://health-study.joinzoe.com/data Reinfections now common https://www.independent.co.uk/news/he... https://www.science.org/doi/10.1126/s... Generally, infections tend to milder the second or third time round Danny Altmann, professor of immunology, Imperial College London Omicron is poorly immunogenic, which means that catching it offers little extra protection against catching it again Prof Tim Spector There are definitely a lot of people who got Covid at the start of the year who are getting it again, including some with BA.4/5 who had BA.1/2 just four months ago rare to be reinfected with within three months BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection https://www.nature.com/articles/s4158... New sub-variants notably evade the neutralising antibodies elicited by SARS-CoV-2 infection and vaccination Vaccine boosters based on the BA.1 virus (e.g. those developed by Pfizer/BioNTech and Moderna) may not achieve broad-spectrum protection against new Omicron variants Dr. Onyema Ogbuagu, Yale School of Medicine, Connecticut My personal bias is that while there may be some advantage to having an Omicron-specific vaccine, I think it will be of marginal benefit over staying current with the existing vaccines and boosters Despite immune evasion, the expectation can be that vaccines will still protect against serious disease What we’ve learned clinically is that it’s most important to stay up-to-date with vaccines to maintain high levels of COVID-19 antibodies circulating in the blood Kei Sato, University of Tokyo New sub-variants may have evolved to refavour infection of lung cells Risk is potentially greater than that of original BA.2 Dr Stephen Griffin, University of Leeds It looks as though these things are switching back to the more dangerous form of infection, so going lower down in the lung Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5 https://www.nejm.org/doi/full/10.1056... Subvariants BA.1 and BA.2, substantial escape from neutralizing antibodies Subvariants BA.4 and BA.5 have identical sequences of spike protein Comparison of neutralizing antibody titer WA1/2020 isolate with BA.1, BA.2, BA.2.12.1, and BA.4 or BA.5 Isolate USA-WA1/2020 from an oropharyngeal swab, returned from China, who and developed clinical disease, January 2020 in Washington, USA In 27 participants, all vaccinated and boosted with Pfizer, And 27 participants who had been infected with the BA.1 or BA.2 median 29 days earlier (range, 2 to 113 days) In the vaccine cohort Participants were excluded, if they had a history of SARS-CoV-2 infection, or a positive result on nucleocapsid serologic analysis, or if they had received another covid vaccine, or an immunosuppressive medication Six months after the initial two BNT162b2 immunizations Neutralizing antibody titer against WA1/2020 = 124 Neutralizing antibody titer against omicron subvarients = 20 Two weeks after administration of the booster dose Neutralizing antibody titer against WA1/2020 = 5,783 Neutralizing antibody titer against BA.1 = 900 BA.2 = 892 BA.2.12.1 = 410 BA.4 or BA.5 = 275 (21 times lower than 5,783) What about natural immunity Among the participants who had been infected with BA.1 or BA.2, 26 had been vaccinated Median neutralizing antibody titer WA1/2020 isolate = 11,050 BA.1 = 1,740 BA.2 = 1,910 BA.2.12.1 = 1,150 BA.4 or BA.5 = 590 (18.7 times less than 11,050) These data show that the BA.2.12.1, BA.4, and BA.5 subvariants substantially escape neutralizing antibodies induced by both vaccination and infection. SARS-CoV-2 omicron variant has continued to evolve with increasing neutralization escape. These findings provide immunologic context for the current surges caused by the BA.2.12.1, BA.4, and BA.5 subvariants, in populations with high frequencies of vaccination and BA.1 or BA.2 infection.
 

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COVID Reinfection Outcomes Are Not Good (Preprint Study)
29 min 01 sec
Streamed live 7 hours ago
Drbeen Medical Lectures

COVID Reinfection Outcomes Are Not Good (Preprint Study) This study shows that a reinfection increases the risk of hospitalization, death, and sequala regardless of the vaccination status. Let's review. My notes. According to the study in pre-print, reinfection compared to infection almost doubles the risk of one symptom staying present up to 6 months after the reinfection. The risk for hospitalization is triple compared to hospitalization after infection - not necessarily related to covid, in general. Risk for all cause mortality after reinfection is double than for infection. Vaccines made no difference.
 

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Mayo Clinic Reveals Data on Rebound COVID-19 Symptoms After Paxlovid Treatment
By Mayo Clinic July 5, 2022

In a Mayo Clinic study published in the journal Clinical Infectious Diseases, only 4 people out of 483 high-risk patients treated with Paxlovid developed COVID-19 rebound symptoms.

Mayo Clinic researchers studied the outcomes of treating high-risk patients for COVID-19 with a five-day oral regimen of nirmatrelvir and ritonavir, which are together marketed as Paxlovid. Out of 483 high-risk patients, only a handful developed COVID rebound symptoms, and the scientists say more research is needed to determine why.

Overall, the Paxlovid treatment benefited everyone in the study. All patients recovered, including those who developed rebound symptoms, which were generally mild. The findings were published on June 14, 2022, in the journal Clinical Infectious Diseases.

“We found that rebound phenomenon was uncommon in this group of patients,” says senior author Aditya Shah, M.B.B.S., a Mayo Clinic infectious diseases physician and researcher. “The four individuals who experienced rebound (symptoms) represent only 0.8% of the group, and all of them recovered quickly without additional COVID-directed therapy.”

Most of the patients in the study had been vaccinated, and many had received booster vaccinations. The median age was 63. While these patients were high-risk for COVID-19, none was immunocompromised. Only two patients were admitted to the hospital, and it was for reasons other than COVID.

The study zeros in on four patients with rebound symptoms:
  • A 75-year-old man with coronary artery disease who had increased cough and muscle aches 19 days after treatment.
  • A 69-year-old man with hypertension and obesity who exhibited nasal discharge and cough 10 days following therapy.
  • A 40-year-old woman with obesity, hypertension, and kidney disease who developed fatigue and sore throat six days after treatment.
  • A 70-year-old man with a history of prostate cancer, obesity, hypertension, and high cholesterol, who developed significant sinus congestion 10 days after treatment.
Why did some rebound?

Researchers think one explanation could be that a replication of the SARS-CoV-2 virus — the virus that causes COVID-19 — may have triggered a secondary immune response that showed up as mild COVID-19 symptoms. They suggest further prospective studies could answer the question. They also note that all four patients with rebound symptoms had many serious health problems known as comorbidities — a factor known to complicate recoveries. Also, all four patients had been vaccinated more than 90 days before becoming infected with COVID-19.

Reference: “Rebound Phenomenon after Nirmatrelvir/Ritonavir Treatment of Coronavirus Disease-2019 in High-Risk Persons” by Nischal Ranganath, MD, PhD, John C. O’Horo, MD, MPH, Douglas W. Challener, MD, MS, Sidna M. Tulledge-Scheitel, MD, MPH, Marsha L. Pike, APRN, CNS, DNP, R. Michael O’Brien, Ph, Raymund R. Razonable, MD, Aditya Shah, MBBS, 14 June 2022, Clinical Infectious Diseases.

DOI: 10.1093/cid/ciac481

Mayo Clinic funded the study. Others on the study team include first author Nischal Ranganath M.D., Ph.D.; John O’Horo, M.D.; Douglas Challener, M.D.; Sidna Tulledge-Scheitel, M.D.; Marsha Pike, D.N.P.; Michael O’Brien; and Raymund Razonable, M.D. — all of Mayo Clinic.
 

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Intense Exercise Can Increase Your Risk of Catching Infectious Diseases Like COVID-19
By Technical University of Munich (TUM)
July 5, 2022

The relationship between exercise intensity and infection risk

The relationship between exercise intensity and the emission and concentration of aerosol particles in exhaled air has not been well understood up to this point. A Munich research team has shown using a unique experimental setup that aerosol emissions rise exponentially with high levels of physical activity. This means indoor athletic events have an increased risk of infectious diseases like COVID-19.

Before the research, it was known that untrained individuals’ respiratory volumes rise during exercise from 5 to 15 liters per minute at rest to over 100 liters per minute. In fact, well-trained athletes can reach 200 l/min levels. It was also recognized that a lot of individuals had contracted the SARS-CoV-2 virus while working out indoors.

However, it was unclear how exercise intensity was related to the number of aerosols that a person actually inhaled per minute and the concentration of aerosol particles in exhaled air, and thus the potential danger of transmitting infectious diseases like SARS-CoV-2. However, this knowledge is urgently required, for instance, to build mitigation measures for school gyms and other indoor sports facilities, fitness studios, or discos to prevent a shutdown in case of major waves of infection.

The new methodology delivers individually measurable aerosol values

A team led by Henning Wackerhage, a Professor of Exercise Biology at the Technical University of Munich (TUM), and Prof. Christian J. Kähler, the Director of the Institute of Fluid Mechanics and Aerodynamics at the Universität der Bundeswehr München, has developed a new investigative method for studying these questions.

Their experimental apparatus initially filtered out the aerosols already present in the ambient air. In the subsequent ergometer stress test, the test subjects inhaled the purified air through a special mask covering the mouth and nose. The exercise intensity was gradually increased from rest to the point of physical exhaustion. The mask was connected to a two-way valve through which only the exhaled air can escape.

The number of aerosol particles emitted per minute was then measured and directly linked to the current performance of the healthy, 18-40-year-old test subjects.

Moderate aerosol emissions at medium exertion

The researchers were thus able to investigate for the first time how many aerosol particles are exhaled per minute by an individual at various levels of exercise intensity. The result: aerosol emissions during exercise initially increased only moderately up to an average workload of around 2 watts per kilogram of body weight. Above that point, however, they rose exponentially. That means that an individual who weighs 75 kilograms reaches that threshold at an ergometer reading of around 150 watts. This corresponds to moderate effort for a casual athlete, perhaps comparable to the exercise intensity of moderate jogging.

The aerosol emissions of well-trained athletes were significantly higher than those of untrained test subjects at maximum effort due to their much higher minute ventilation. The researchers did not find significant differences in particle emissions between genders.

Protective measures are important for high-intensity training

Although the aerosol experiments provide only indirect knowledge on the number of viruses in exhaled air, the study suggests useful starting points for managing indoor activities when a wave of infection combined with a poorly immunized population threatens to overwhelm the healthcare system.

“Based on our results, we distinguish between moderate endurance training with an intensity of up to 2 watts per kilogram of body weight and training at high to maximum intensity. Due to the sharp rise in aerosol emissions at high-intensity workloads above that initial benchmark, special protective measures are needed in case of a high risk of infections with serious consequences,” says study leader Prof. Wackerhage: “Ideally, that kind of training would be moved outdoors. If that is not possible, testing should be done to ensure that no infected individuals are in the room. The participants should also maintain a proper distance and a high-efficiency ventilation system should be running. In addition, infection risks are reduced by training at lower intensities and keeping sessions shorter. It might also be possible for fit, young athletes to wear masks while training.” At low workloads such as easy to moderately intense endurance training, adds Prof. Wackerhage, less protection is needed and the infection risk can be controlled through distancing and ventilation systems.

The research team is currently conducting experiments to compare aerosol emissions in strength and endurance training and to correlate them with test subjects’ ages and physical characteristics.

The study was funded by the German Federal Institute of Sports Science (BISp) and the German Research Foundation (DFG).

Reference: “Aerosol particle emission increases exponentially above moderate exercise intensity resulting in superemission during maximal exercise” by Benedikt Mutsch, Marie Heiber, Felix Grätz, Rainer Hain, Martin Schönfelder, Stephanie Kaps, Daniela Schranner, Christian J. Kähler and Henning Wackerhage, 23 May 2022, Proceedings of the National Academy of Sciences.

DOI: 10.1073/pnas.2202521119
 

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Inhalable COVID vaccine shows promise in rodent model
by Tracey Peake, North Carolina State University
July 5, 2022

1657096195405.jpeg
Inhalation of the RBD-Exo VLP vaccine induces SARS-CoV-2 neutralization in hamsters and protects their lungs. Schematic representation of the fabrication of the RBD-Exo vaccine, which is delivered into the lungs via inhalation. RBD-Exo induces mucosal immunity and systemic immunity with the generation of RBD-specific IgA and IgG antibodies against SARS-CoV-2 infection in hamsters. This schematic was created with BioRender.com. Credit: Nature Biomedical Engineering (2022). DOI: 10.1038/s41551-022-00902-5

Researchers have created an inhalable COVID-19 vaccine that is shelf stable at room temperature for up to three months, targets the lungs specifically and effectively, and allows for self-administration via an inhaler. The researchers also found that the delivery mechanism for this vaccine—a lung-derived exosome called LSC-Exo—is more effective at evading the lung's mucosal lining than the lipid-based nanoparticles currently in use, and can be used effectively with protein-based vaccines.

Ke Cheng, the Randall B. Terry Jr. Distinguished Professor in Regenerative Medicine at NC State and a professor in the NC State/UNC-Chapel Hill Joint Department of Biomedical Engineering, along with colleagues from UNC-Chapel Hill and Duke University, led the development of the vaccine prototype from proof-of-concept to animal studies.

"There are several challenges associated with vaccine delivery we wanted to address," Cheng says. "First, taking the vaccine via intramuscular shot is less efficient at getting it into the pulmonary system, and so can limit its efficacy. Inhaled vaccines would increase their benefit against COVID-19.

"Second, mRNA vaccines in their current formulation require cold storage and trained medical personnel to deliver them. A vaccine that is stable at room temperature and that could be self-administered would greatly reduce wait times for patients as well as stress on the medical profession during a pandemic. However, reformulating the delivery mechanism is necessary for it to work through inhalation."

In order to deliver the vaccine directly to the lungs, the researchers used exosomes (Exo) secreted from lung spheroid cells (LSCs). Exosomes are nanosized vesicles that have recently been recognized as an excellent means of drug delivery.

First, the researchers looked at whether LSC-Exo was able to deliver protein or mRNA "cargos" throughout the lungs. The researchers compared the distribution and retention of LSC-Exo to nanoparticles similar to lipid nanoparticles currently used with mRNA vaccines. In a paper in Extracellular Vesicle, the researchers demonstrated that lung-derived nanoparticles were more effective at delivering mRNA and protein cargo to bronchioles and deep lung tissue than synthetic liposome particles.

Next, the researchers created and tested an inhalable, protein-based, virus-like particle (VLP) vaccine by decorating the exterior of LSC-Exo with a portion of the spike protein—known as the receptor binding domain, or RBD—from the SARS-CoV-2 virus. A paper describing the research is published in Nature Biomedical Engineering.

"Vaccines can work through various means," Cheng says. "For example, mRNA vaccines deliver a script to your cell that instructs it to produce antibodies to the spike protein. This VLP vaccine, on the other hand, introduces a portion of the spike protein to the body, triggering the immune system to produce antibodies to the spike protein."

In rodent models, the RBD-decorated LSC-Exo vaccine (RBD-Exo) elicited production of antibodies specific to the RBD, and protected the rodents, after two vaccine doses, from infection with live SARS-CoV-2. Additionally, the RBD-Exo vaccine remained stable at room temperature for three months.

The researchers note that while the work is promising, there are still challenges associated with large-scale production and purification of the exosomes. LSCs, the cell type used for generating RBD-Exo, are currently in a Phase I clinical trial by the same researchers for treating patients with degenerative lung diseases.

"An inhalable vaccine will confer both mucosal and systemic immunity, it's more convenient to store and distribute, and could be self-administered on a large scale," Cheng says. "So while there are still challenges associated with scaling up production, we believe that this is a promising vaccine worthy of further research and development."
 

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For COVID-19, endemic stage could be two years away
By Mallory Locklear, Yale University
July 5, 2022

1657096262844.jpeg
SARS-CoV-2 Disease Compartment Curves for Model 1 with predominantly in vivo rat study estimates (a) and (b) and human-adapted estimates (c) and (d) accounting for the effects of successive variants and varying immunity (e) and (f). (a) and (b): using predominantly rat data, iterated for 365 days (a) and for 1,825 days (b). The model stabilizes after approximately 724 days at an endemic state with approximately 41% of the population susceptible to reinfection. (c) and (d): using translational human estimates, iterated for 365 days (c) and for 1,825 days (d). Curves are the median at time t (25th and 75th percentile) to show the sensitivity of the curves to our set of chosen parameters. When an analysis of endemic stability across all parameter choices is performed , endemic stability is reached at a median of 1,119 days (IQR = 1017.75). (e) and (f): assessing an introduction of variants into our SARS-CoV-2 Disease Compartment Curves with human estimates and introducing increasingly transmissible variants at 180-day intervals. In (e), we model decreasing length of natural immune protection from reinfection, whereas in (f), immune protection is held constant. The compartments and associated curves are denoted in the legend and are defined as follows: susceptible (yellow; S), exposed (light blue; E), infected (green; I), seropositive recovered (dark blue; R+), and low-risk/fomite (orange; L). Population size (closed with no births or deaths) is given as # of individuals on the Y-axis. Credit: PNAS Nexus (2022). DOI: 10.1093/pnasnexus/pgac096

Illnesses like the common cold and the flu have become endemic in human populations; everyone gets them every now and then, but for most people, they aren't especially harmful. COVID-19 will eventually transition to endemic status at some point—but when?

Possibly within two years, according to a new Yale study published July 5 in the journal PNAS Nexus.

To develop a better understanding of when and how COVID-19 might become endemic, Yale researchers turned to rats, which, like us, are also susceptible to coronaviruses. By collecting data on coronaviral reinfection rates among rats, they were able to model the potential trajectory of COVID-19.

There are many different types of coronaviruses, including SARS-CoV-2—the virus behind COVID-19—and several that cause the common cold. Animals like pigs and chickens live with endemic coronaviruses, too, and a key factor identified in the spread of animal and human coronaviruses alike is their tendency to evoke what's known as non-sterilizing immunity.

"It means that initially there is fairly good immunity, but relatively quickly that wanes," said Caroline Zeiss, a professor of comparative medicine at Yale School of Medicine and senior author of the study. "And so even if an animal or a person has been vaccinated or infected, they will likely become susceptible again."

Over the past two years, scientists have come to see that SARS-CoV-2 yields non-sterilizing immunity; people who have been infected or vaccinated are still at risk of reinfection. So experts expect that the virus won't go away any time soon.

To better understand what SARS-CoV-2 might do over time, scientists have used mathematical models. And given the strong similarities between animal and human coronaviruses, collecting relevant data from animals presents an opportunity to better understand SARS-CoV-2, says Zeiss.

"There are many lessons to be learned from animal coronaviruses," she said.

In this study, Zeiss and her colleagues observed how a coronavirus similar to one that causes the common cold in humans was transmitted through rat populations. The team modeled the exposure scenario to resemble human exposures in the United States, where a portion of the population is vaccinated against COVID-19 and where people continue to face natural exposure to SARS-CoV-2. They also reproduced the different types of exposure experienced by people in the U.S., with some animals exposed through close contact with an infected rat (high risk of infection) and others exposed by being placed in a cage once inhabited by an infected rat (low risk of infection).

Infected animals contracted an upper respiratory tract infection and then recovered. After three to four months, the rats were then reorganized and re-exposed to the virus. The rates of reinfection showed that natural exposure yielded a mix of immunity levels, with those exposed to more virus through close contact having stronger immunity, and those placed in a contaminated cage (and therefore exposed to lower amounts of the virus) having higher rates of reinfection.

The takeaway, Zeiss says, is that with natural infection, some individuals will develop better immunity than others. People also need vaccination, which is offered through a set dose and generates predictable immunity. But with both vaccination and natural exposure, the population accumulates broad immunity that pushes the virus toward endemic stability, the study showed.

She and her team then used this data to inform mathematical models, finding that the median time it could take for SARS-CoV-2 to become endemic in the United States is 1,437 days, or just under four years from the start of the pandemic in March 2020.

In this scenario, according to the model, 15.4% of the population would be susceptible to infection at any given time after it reaches endemic phrase.

"The virus is constantly going to be circulating," said Zeiss. So it will be important to keep more vulnerable groups in mind. "We can't assume that once we reach the endemic state that everybody is safe."

Four years is the median time predicted by the model, she said, so it could take even longer to reach the endemic stage. And this doesn't take into account mutations that could make SARS-CoV-2 more harmful.

"Coronaviruses are very unpredictable, so there could be a mutation that makes it more pathogenic," said Zeiss. "The more likely scenario, though, is that we see an increase in transmissibility and probable decrease in pathogenicity." That means the virus would be easily transmitted between people but less likely to cause severe illness, much like the common cold.

There is precedent for this trajectory. In the late 1800s, what was known as the "Russian flu" killed approximately one million people around the world. Researchers now think the virus behind that pandemic was a coronavirus that originated in cattle and eventually evolved into one of the common cold viruses still in circulation. Reduced pathogenicity associated with the transition from epidemic to endemic status has also been observed in pig coronaviruses. And almost all commercial chicken flocks across the globe are vaccinated for an endemic respiratory coronavirus that has been present since the 1930s.

Longstanding experience with coronaviral infections in other animals can help us navigate a pathway to living with SARS-CoV-2.

However, endemic stability in the United States also depends on what happens to the virus elsewhere.

"We are one global community," Zeiss said. "We don't know where else these mutations are going to arise. Until we reach endemic stability around the entire globe, we are vulnerable here to having our U.S. endemic stability disrupted by introduction of a new variant.

"But I think overall the picture's hopeful. I think we will be in endemic stability within the next year or two."
 

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Vitamin D supplement 'overdosing' is possible and harmful, warn doctors
by British Medical Journal
July 5, 2022

'Overdosing' on vitamin D supplements is both possible and harmful, warn doctors in the journal BMJ Case Reports after they treated a man who needed hospital admission for his excessive vitamin D intake.

'Hypervitaminosis D', as the condition is formerly known, is on the rise and linked to a wide range of potentially serious health issues, they highlight.

The case concerns a middle-aged man who was referred to hospital by his family doctor after complaining of recurrent vomiting, nausea, abdominal pain, leg cramps, tinnitus (ringing in the ear), dry mouth, increased thirst, diarrhea, and weight loss (28 lbs or 12.7 kg).

These symptoms had been going on for nearly 3 months, and had started around 1 month after he began an intensive vitamin supplement regimen on the advice of a nutritional therapist.

The man had had various health issues, including tuberculosis, an inner ear tumor (left vestibular schwannoma), which had resulted in deafness in that ear, a build-up of fluid in the brain (hydrocephalus), bacterial meningitis, and chronic sinusitis.

He had been taking high doses of more than 20 over the counter supplements every day containing: vitamin D 50000 mg—the daily requirement is 600 mg or 400 IU; vitamin K2 100 mg (daily requirement 100–300 μg); vitamin C, vitamin B9 (folate) 1000 mg (daily requirement 400 μg); vitamin B2 (riboflavin), vitamin B6, omega-3 2000 mg twice daily (daily requirement 200–500 mg), plus several other vitamin, mineral, nutrient, and probiotic supplements.

Once symptoms developed, he stopped taking his daily supplement cocktail, but his symptoms didn't go away.

The results of blood tests ordered by his family doctor revealed that he had very high levels of calcium and slightly raised levels of magnesium. And his vitamin D level was 7 times over the level required for sufficiency.

The tests also indicated that his kidneys weren't working properly (acute kidney injury). The results of various X-rays and scans to check for cancer were normal.

The man stayed in hospital for 8 days, during which time he was given intravenous fluids to flush out his system and treated with bisphosphonates—drugs that are normally used to strengthen bones or lower excessive levels of calcium in the blood.

Two months after discharge from hospital, his calcium level had returned to normal, but his vitamin D level was still abnormally high.

"Globally, there is a growing trend of hypervitaminosis D, a clinical condition characterized by elevated serum vitamin D3 levels," with women, children and surgical patients most likely to be affected, write the authors.

Recommended vitamin D levels can be obtained from the diet (eg wild mushrooms, oily fish), from exposure to sunlight, and supplements.

"Given its slow turnover (half-life of approximately 2 months), during which vitamin D toxicity develops, symptoms can last for several weeks," warn the authors.

The symptoms of hypervitaminosis D are many and varied, they point out, and are mostly caused by excess calcium in the blood. They include drowsiness, confusion, apathy, psychosis, depression, stupor, coma, anorexia, abdominal pain, vomiting, constipation, peptic ulcers, pancreatitis, high blood pressure, abnormal heart rhythm, and kidney abnormalities, including renal failure.

Other associated features, such as keratopathy (inflammatory eye disease), joint stiffness (arthralgia), and hearing loss or deafness, have also been reported, they add.

This is just one case, and while hypervitaminosis D is on the rise, it is still relatively uncommon, caution the authors.

Nevertheless, complementary therapy, including the use of dietary supplements, is popular, and people may not realize that it's possible to overdose on vitamin D, or the potential consequences of doing so, they say.

"This case report further highlights the potential toxicity of supplements that are largely considered safe until taken in unsafe amounts or in unsafe combinations," they conclude.
 

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COVID-19 vaccination activates antibodies targeting parts of virus spike protein shared between coronaviruses
by Northern Arizona University
July 5, 2022

1657096451731.jpeg
Graphical abstract. Credit: Cell Reports (2022). DOI: 10.1016/j.celrep.2022.111022

Could the SARS-CoV-2 vaccine reawaken previous antibody responses and point the way to a universal coronavirus vaccine? A new analysis of the antibody response to a COVID-19 vaccine suggests the immune system's history with other coronaviruses, including those behind the common cold, shapes the patient's response, according to a study published today in Cell Reports.

Led by scientists at the Translational Genomics Research Institute (TGen), part of City of Hope, and Northern Arizona University (NAU), a research team found that the vaccine generates antibodies that target regions of the SARS-CoV-2 spike protein that are unique to the new virus, while also targeting regions of the protein that are shared or conserved among many coronaviruses.

What's more, the antibody response to these different coronaviruses appears to follow different paths. Over the course of 140 days following vaccination, the response to common cold coronaviruses started early but diminished over time. The response to SARS-CoV-2 continued to get stronger and stronger over time.

"The findings could help fine-tune the design of future vaccines or new monoclonal antibody treatments, perhaps leading to a universal coronavirus vaccine," said John Altin, Ph.D., senior author and assistant professor in TGen's Pathogen Genomics and Integrated Cancer Genomics Divisions.

"Even if the response to the conserved regions is just a small part of the vaccine's overall protection, it may be a response that could be leveraged in future vaccines against future variants of the COVID-19 virus," he added.

Altin and colleagues are now looking more closely at the antibodies that target the two conserved regions they identified in their study to determine whether these are broadly neutralizing antibodies that generate immunity extending to new variants of the virus.

Using a technology called PepSeq developed by Altin and co-author Jason Ladner, Ph.D., an assistant professor at NAU's Pathogen and Microbiome Institute, allowed the researchers to carefully map antibody responses and track them serially over 140 days in 21 people who received the Moderna SARS-CoV-2 vaccine. The technology matches individual peptides (the building blocks of proteins) with unique DNA tags. The tags allow scientists to pinpoint which peptides are being targeted by antibodies.

Before technologies like PepSeq, researchers had to measure the response of antibodies against one protein target at a time.

"PepSeq allows us to perform up to hundreds of thousands of measurements of antibodies against different parts of virus proteins all at the same time from the same sample," Ladner said.

PepSeq also helps scientists precisely map the antibody response to specific regions of a protein. This allowed Ladner, Altin and their colleagues to track the differences in antibody response between divergent and conserved regions of the SARS-CoV-2 Spike protein.

"Our theory is that there is actually memory from previous common cold coronavirus encounters, and when you get the vaccine for SARS-CoV-2, the vaccine reawakens some of those memories. Then you see this early response which is basically just a rapid memory response to what you've already seen," Altin said. "With time, the immune system can reshape those responses more in the direction of the pandemic virus."

Before COVID-19, Ladner and Altin were using PepSeq to get a closer look at the full range of viruses that infect humans. The powerful technology offers a way to "understand something about the viruses that a person has been exposed to in the past and the immune response to those infections," Ladner said.

For instance, Ladner and his colleagues are looking at whether some chronic diseases, such as type 1 diabetes and celiac disease, might have some of their roots in different viral exposures. They also use the technology to look for different rates of infection between different populations, to see how this exposure history might be related to health disparities between those populations.
 

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Small study reveals how immune response triggered by COVID-19 may damage the brain
by National Institutes of Health
July 5, 2022

1657096536452.jpeg
Researchers found that SARS-CoV-2 infection can trigger the production of immune molecules that damage cells lining blood vessels in the brain. This causes platelets to stick together and form clots. At the same time, blood proteins leak from the blood vessels causing neuroinflammation and the destruction of neurons. Credit: NIH\NINDS

A study from the National Institutes of Health describes the immune response triggered by COVID-19 infection that damages the brain's blood vessels and may lead to short- and long-term neurological symptoms. In a study published in Brain, researchers from the National Institute of Neurological Disorders and Stroke (NINDS) examined brain changes in nine people who died suddenly after contracting the virus.

The scientists found evidence that antibodies—proteins produced by the immune system in response to viruses and other invaders—are involved in an attack on the cells lining the brain's blood vessels, leading to inflammation and damage. Consistent with an earlier study from the group, SARS-CoV-2 was not detected in the patients' brains, suggesting the virus was not infecting the brain directly.

Understanding how SARS-CoV-2 can trigger brain damage may help inform development of therapies for COVID-19 patients who have lingering neurological symptoms.

"Patients often develop neurological complications with COVID-19, but the underlying pathophysiological process is not well understood," said Avindra Nath, M.D., clinical director at NINDS and the senior author of the study. "We had previously shown blood vessel damage and inflammation in patients' brains at autopsy, but we didn't understand the cause of the damage. I think in this paper we've gained important insight into the cascade of events."

Dr. Nath and his team found that antibodies produced in response to COVID-19 may mistakenly target cells crucial to the blood-brain barrier. Tightly packed endothelial cells help form the blood-brain barrier, which keeps harmful substances from reaching the brain while allowing necessary substances to pass through. Damage to endothelial cells in blood vessels in the brain can lead to leakage of proteins from the blood. This causes bleeds and clots in some COVID-19 patients and can increase the risk of stroke.

For the first time, researchers observed deposits of immune complexes—molecules formed when antibodies bind antigens (foreign substances)—on the surface of endothelial cells in the brains of COVID-19 patients. Such immune complexes can damage tissue by triggering inflammation.

The study builds on their previous research, which found evidence of brain damage caused by thinning and leaky blood vessels. They suspected that the damage may have been due to the body's natural inflammatory response to the virus.

To further explore this immune response, Dr. Nath and his team examined brain tissue from a subset of patients in the previous study. The nine individuals, age 24 to 73, were chosen because they showed signs of blood vessel damage in the brain based on structural brain scans. The samples were compared to those from 10 controls. The team looked at neuroinflammation and immune responses using immunohistochemistry, a technique that uses antibodies to identify specific marker proteins in the tissues.

As in their earlier study, researchers found signs of leaky blood vessels, based on the presence of blood proteins that normally do not cross the blood brain barrier. This suggests that the tight junctions between the endothelial cells in the blood brain barrier are damaged.

Dr. Nath and his colleagues found evidence that damage to endothelial cells was likely due to an immune response—discovering deposits of immune complexes on the surface of the cells.

These observations suggest an antibody-mediated attack that activates endothelial cells. When endothelial cells are activated, they express proteins called adhesion molecules that cause platelets to stick together. High levels of adhesion molecules were found in endothelial cells in the samples of brain tissue.

"Activation of the endothelial cells brings platelets that stick to the blood vessel walls, causing clots to form and leakage to occur. At the same time the tight junctions between the endothelial cells get disrupted causing them to leak," Dr. Nath explained. "Once leakage occurs, immune cells such as macrophages may come to repair the damage, setting up inflammation. This, in turn, causes damage to neurons."

Researchers found that in areas with damage to the endothelial cells, more than 300 genes showed decreased expression, while six genes were increased. These genes were associated with oxidative stress, DNA damage, and metabolic dysregulation. This may provide clues to the molecular basis of neurological symptoms related to COVID-19 and offer potential therapeutic targets.

Together, these findings give insight into the immune response damaging the brain after COVID-19 infection. But it remains unclear what antigen the immune response is targeting, as the virus itself was not detected in the brain. It is possible that antibodies against the SARS-CoV-2 spike protein could bind to the ACE2 receptor used by the virus to enter cells. More research is needed to explore this hypothesis.

The study may also have implications for understanding and treating long-term neurological symptoms after COVID-19, which include headache, fatigue, loss of taste and smell, sleep problems, and "brain fog." Had the patients in the study survived, the researchers believe they would likely have developed Long COVID.

"It is quite possible that this same immune response persists in Long COVID patients resulting in neuronal injury," said Dr. Nath. "There could be a small indolent immune response that is continuing, which means that immune-modulating therapies might help these patients. So these findings have very important therapeutic implications."

The results suggest that treatments designed to prevent the development of the immune complexes observed in the study could be potential therapies for post-COVID neurological symptoms.
 

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COVID vaccine saves lives regardless of body weight
By Amy Norton
July 5, 2022

COVID vaccination is highly protective against severe disease in people of all body weights, new British research finds.

The study of over 9 million adults found that those who'd received two doses of a COVID-19 vaccine were strongly protected against hospitalization or death from the disease. And the effectiveness was just as great for obese people as those with a healthy weight.

That had been a concern, as there is evidence the flu vaccine is less effective for people with obesity, said lead researcher Carmen Piernas-Sanchez, from the University of Oxford.

"This prompted us to look into COVID vaccines," she explained.

Based on the findings, the vaccines are similarly effective for people who are normal weight, overweight or obese. But, Piernas-Sanchez said, more research is still needed to understand why obesity appears to make people more vulnerable to becoming severely ill when they do contract COVID.

For now, she and other experts stressed the importance of vaccination, including booster shots.

"The vaccines aren't perfect, and you can still get COVID. But they are very effective against severe disease," said Dr. Aaron Glatt, chief of infectious diseases at Mount Sinai South Nassau, in Oceanside, N.Y.

The latest study looked at the pre-Omicron era, but Glatt said the vaccines remain highly effective against severe COVID.

Dr. Lalitha Parameswaran, an infectious disease specialist at NYU Langone Hospital Brooklyn, agreed.

"Vaccination remains the most important method to avoid severe illness and death from COVID, and this has remained true in the Omicron era," Parameswaran said.

Booster doses, she added, offer protection against mild to moderate illness, and "further enhance the protective response to severe illness."

The findings, published recently in The Lancet Diabetes and Endocrinology, are based on medical records from over 9 million British adults. Between December 2020 and November 2021, over 566,000 tested positive for COVID; about 33,800 were hospitalized, while just under 14,400 died.

Overall, the study found, people who received two doses of any COVID vaccine given in the United Kingdom—AstraZeneca, Pfizer or Moderna—were much less likely to fall seriously ill.

Vaccination cut the risk of hospitalization by almost 70% among overweight, obese and normal-weight adults, compared to their counterparts who were unvaccinated. There was a similar reduction in the risk of dying from COVID-19.

People who were underweight showed somewhat less protection: Vaccination lowered their risk of being hospitalized for COVID by half, and their risk of dying by 40%, the investigators found.

It's not clear why, according to Piernas-Sanchez. But she noted it's possible that some underweight people had health conditions, including cancer, that lower the immune response to vaccines.

The researchers also found that when vaccinated people did get COVID, those who were obese faced a greater risk of landing in the hospital or dying than people in the normal-weight range.

It's been recognized since early in the pandemic that obese people are at increased risk of severe COVID-19. Experts believe there are several reasons: Obesity can impair immune function and make people more prone to clotting and breathing problems, for example.

"Given the high effectiveness of the vaccines, the absolute number of severe cases was reduced massively," Piernas-Sanchez said. "But among the fewer severe cases that are happening, those with low or high body weights are at increased risks, compared with people of a healthy weight."

It all suggests that achieving a healthy weight will help protect people from severe COVID-19, Piernas-Sanchez said.

What about booster shots? In this study, few people of any weight got severely ill after a COVID booster dose.

But, the researchers said, more studies are needed to know whether booster doses erase the excess risk linked to obesity.

That said, all three experts advised people to get the recommended booster doses. The U.S. Centers for Disease Control and Prevention is advising a second booster shot for adults age 50 and older, and some younger people who are immune-compromised.

The study also found that underweight adults were less likely than everyone else to be vaccinated: About one-third were unvaccinated as of November 2021.

Again, the reasons are unknown. But the researchers speculate that public health messages, which emphasize the risks tied to obesity, might give thin people the idea that they have nothing to worry about.
 

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Dominant omicron subvariants are better at evading vaccines and antibody treatments
by Columbia University Irving Medical Center
July 5, 2022

The latest omicron subvariants—including the BA.4 and BA.5 forms causing new surges in infections in the United States—are even better at eluding vaccines and most antibody treatments than previous variants, finds a study by researchers at Columbia University Vagelos College of Physicians and Surgeons.

The study, led by David D. Ho, MD, director of the Aaron Diamond AIDS Research Center and the Clyde'56 and Helen Wu Professor of Medicine at Columbia University Vagelos College of Physicians and Surgeons, was published July 5 in Nature.

Subvariants BA.2.12.1, BA.4, and BA.5 are rapidly expanding worldwide, with BA.4/5 now making up more than 50% of new COVID cases in the United States. These subvariants are thought to be even more transmissible than prior omicron subvariants, owing to several new mutations in spike proteins.

"The virus is continuing to evolve, as expected, and it is not surprising that these new, more transmissible subvariants are becoming more dominant around the world," says Ho. "Understanding how currently available vaccines and antibody treatments stand up to the new subvariants is critical to developing strategies to prevent severe disease, hospitalizations, and deaths—if not infection."

In laboratory experiments, Ho and his team studied the ability of antibodies from individuals who had received at least three doses of an mRNA vaccine, or got two shots and were then infected with omicron, to neutralize the new subvariants. (Ho's team did not look at individuals who had not received a booster shot, because a previous study found that two doses provide little protection against infection by earlier omicron variants.)

The study revealed that while BA.2.12.1 is only modestly more resistant than BA.2 in individuals who were vaccinated and boosted, BA.4/5 was at least four times more resistant than its predecessor.

In addition, the scientists tested the ability of 19 monoclonal antibody treatments to neutralize the variants and found that only one of the available antibody treatments remained highly effective against both BA.2.12.1 and BA.4/5.

"Our study suggests that as these highly transmissible subvariants continue to expand around the globe, they will lead to more breakthrough infections in people who are vaccinated and boosted with currently available mRNA vaccines," Ho says. Though the current study suggests that the new variants may cause more infections in vaccinated individuals, the vaccines continue to provide good protection against severe disease.

"Efforts in the United States to develop new vaccine boosters aimed at BA.4/5 may improve protection against infection and severe disease," Ho says. "In the current environment, though, we may need to look toward developing new vaccines and treatments that can anticipate ongoing evolution of the SARS-CoV-2 virus."
 

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Shanghai, Beijing order new round of mass COVID-19 testing
July 6, 2022

Residents of parts of Shanghai and Beijing have been ordered to undergo further rounds of COVID-19 testing following the discovery of new cases in the two cities, while tight restrictions remain in place in Hong Kong, Macao and other Chinese cities.

Shanghai has only just emerged from a strict lockdown that confined most of its 24 million residents to their homes for weeks and the new requirements have stirred concerns of a return of such harsh measures.

The latest outbreak in China's largest city, a key international business center, has been linked to a karaoke parlor that failed to enforce prevention measures among employees and customers, including the tracing of others they came into contact with, according to the city health commission. All such outlets have been ordered to temporarily suspend business, the city's department of culture and tourism said.

Shanghai's lockdown prompted unusual protests both in person and online against the government's harsh enforcement, which left many residents struggling to access food and medical services and sent thousands to quarantine centers.

Beijing has also seen a recent outbreak linked to a nightlife spot. It has been conducting regular testing for weeks and at least one residential compound in the suburb of Shunyi, which is home to many foreign residents, has been locked down with a steel fence installed over its entrance to prevent residents from leaving.

Enforcement in China's capital has been far milder than in Shanghai, although officials continue to require regular testing and prevention measures.

In the northern city of Xi'an, whose 13 million residents endured one of China's strictest lockdowns over the winter, restaurants have been restricted to takeout only and public entertainment spots closed for a week starting Wednesday.

A notice on the city government's website said the measures were only temporary and intended to prevent the chance of a renewed outbreak. It said supermarkets, offices, public transport and other facilities are continuing to operate as normal, with routine screening including temperature checks and people being required to show an app proving they are free of infection.

The gambling hub of Macao has meanwhile locked down the famed Grand Lisboa Hotel after cases were discovered there. More than a dozen residential and commercial centers in the Chinese special autonomous region of about 650,000 people have been designated as "red zones," with access restricted almost exclusively to emergency workers.

Authorities have ordered most establishments to close with the exception of casinos, which are Macao's main revenue generator and among the city's largest employers.

City residents will have to undergo three citywide COVID-19 tests this week. The local outbreak is Macao's largest since the pandemic began, with more than 900 infections reported since mid-June.

Neighboring Hong Kong has also seen a rising trend of coronavirus infections since mid-June. In the past seven days, daily infections reported averaged about 2,000 a day.

The city's new leader, John Lee, said Wednesday that Hong Kong must not "lie flat" when it comes to COVID-19, rejecting the "living with the coronavirus" mentality that most of the world has adopted.

His comments echo the sentiments of Chinese authorities, who have stuck with their "zero-COVID" policy that has become closely identified with President and head of the ruling Communist Party Xi Jinping.

However, Lee has said that Hong Kong authorities are exploring options, including shortening the duration of mandatory quarantine for incoming travelers. Currently, travelers must test negative for COVID-19 before flying and quarantine for seven days in designated hotels upon arrival.

The city, once known as a bustling business hub and international financial center, has seen tourism and business travel crippled by its tough entry restrictions.

The strict measures have remained in place despite relatively low numbers of cases and the serious negative effects on China's economy and global supply chains.

The World Health Organization recently called the policy unsustainable, a view Chinese officials rejected outright even while they say they hope to minimize the impact.

While China's borders remain largely closed, cutting off both visitors from abroad and outbound tourism, officials have cautiously increased flights from some foreign countries, most recently Russia.

Mainland China reported 353 cases of domestic transmission on Wednesday, 241 of them asymptomatic.

Shanghai announced just 24 cases over the past 24 hours, and Beijing five. Anhui announced 222 cases in what appears to be the latest cluster, prompting the inland province to order mass testing and travel restrictions in Si county, where the bulk of cases have been reported.
 

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In Austria, the finger-pointing has begun!
In Austria, the Minister of Health acknowledges the problems with the vaccines, so he throws the Austrian docs under the bus. Why? Because denial is no longer working and you have to blame someone!
Steve Kirsch
Jul 5

Summary

A tale of three countries:
  1. In Austria, they’ve figured out the vaccines are dangerous, so the Health Minister is now blaming the doctors.
  2. In New Zealand, the data clearly shows the vaccinated have higher all-cause mortality, so their solution is more vaccines and they bury the papers showing the vaccines are the problem.
  3. In Australia, the mandates are gone and a few people are coming to realize they goofed big time.

Austria

SuperSpreader, who is one of my readers, pointed out that the Austrian Health Minister is now blaming doctors for not informing patients of the health risks of vaccines. But, of course, doctors aren’t allowed to blame the vaccines so they are the perfect scapegoats.

Austrian Health Minister and Medical Profession Dispute Responsibility for Massive Covid “Vaccine” Deaths and Health Damage | Paul Craig Roberts

Austrian Minister of Health Confirms – Doctors Are Responsible for Vaccine Damage | The Liberty Beacon

Liability hammer: Minister of Health confirms – doctors responsible for vaccine damage, Now there are penalties of up to 14,000 euros! | WochenBlick (German translated)

Austrian Minister Of Health Shifts Responsibility For Vaccine Damage To Doctors | AnonTimes

You can read more here:

Super Spreader

New Zealand: the vaccinated have higher mortality than the unvaccinated so the solution is more vaccines!!!


The narrative is unraveling in New Zealand as this paper by John Gibson points out that the vaccinated are more likely to die than the unvaccinated.

But no finger pointing in New Zealand!

In New Zealand, the traditional media will not cover any research that is counter-narrative because they are so beholden to government funding. For example, in May the NZ government spent an average of $67 (USD$45) PER DOSE on advertising, and all told it has been about $50 million spent on government advertising on the vaccines. On top of that there is a "public interest journalism fund" that gives about another $100 million of government money to the media. So the public only hears one side of the narrative.

So what do the “experts” in New Zealand like Otago University epidemiologist Professor Michael Baker do?

Baker called for new mRNA vaccines to be rolled out urgently!!!!

No matter how bad the data is, these guys are just never going to point the finger at the vaccines that are making things worse.

For more on this, check out this article The First Pandemic War—highly Vaccinated New Zealand Admits It Is Losing the Battle.

You’ll love it. They admit they are losing that battle so the solution is to keep doing the same thing over and over again hoping for a different result.

Gibson’s earlier paper, Public misunderstanding of pivotal COVID-19 vaccine trials may contribute to New Zealand’s adoption of a costly and economically inefficient vaccine mandate, pointed out that “if the public misunderstanding described here persists, a continuation of inefficient vaccine mandates whose costs exceed benefits is likely.” He was exactly right of course. That is precisely what has happened and will continue to happen. New Zealand will likely be the last place on Earth that they will figure this out.

Australia


They are backing off the vaccine mandates now.

Read Vanishing vaccine mandates: No apology from our once-so-zealous public health officials which says:

Thus, after more than two years of advising premiers to abandon their pandemic plans and paralyse the entire country until everyone was immunised with experimental vaccines, it seems that our public health officers were wrong. Oops. Not only has Australia wasted billions of dollars on lockdowns, it has damaged the health of the vast majority of Australians by making them more vulnerable to infection with Covid.

On the other hand, consider this comment from a reader in Australia:

I think you were overly optimistic about Australia's position. While there are small signs the authorities are backing away from some measures, the shots are still mandated for many categories of workers and one premier has called for health workers to have a mandatory booster shot. All of our governments are still pushing the shots at every opportunity, including for children. Further, the Queensland CHO recently said that masks may need to come back for some indoor settings because case numbers are rising rapidly. I think he only raised it to gauge public reaction. The corporate media are still not reporting anything that contradicts governmental propaganda on the virus, the shots, the war, or inflation.
From reading comments in social media, it appears that a large percentage of our population are still screaming, "Govern me harder Daddy!" We have such a long way to go.
 

Heliobas Disciple

TB Fanatic
There are 11 other tweets that follow this one. Weissman is so good! Posted several weeks ago but he reposted it in light of what GVB has said.

View: https://twitter.com/alltherisks/status/1544455911351193601?s=21&t=W83aknJaLdBZlokPeNertw


This substack also talks about Weissman.



(fair use applies)

The future of endemic Covid-19
We don't even know the half of it
Vinay Prasad
7 hr ago

Recently, someone forwarded me an article about the dark future of living in a world with recurring COVID-19 infections. My first thought was: this article barely scratches the surface.

I turned to Dr Jeffrey Wiseman, a practicing epidemiological consultant for words of wisdom. He delivered. Full disclosure: Dr. Wiseman consults for the mask and testing industries. But there will be no trace of influence in his messianic writing.

Covid-19 reinfections mean the future is dark
By Jeffrey Wiseman

The Biden administration has admitted defeat. The American people are back in bars and restaurants. The world is moving on from COVID-19, but the virus is not done with us.

Although some believe that reinfections will be milder, and inevitable over the course of a lifetime, unless we take drastic action reinfections will destroy all of Human civilization many times over.

A growing body of evidence suggests that even reading articles about COVID can precipitate long COVID. Nevermind repeated exposure to the virus which guarantees it. Each subsequent infection is another opportunity to develop liquefactive, perpetual COVID-19.

Although current controlled studies have failed to detect biochemical perturbations from mild COVID-19 infections when compared to matched controls, that does not mean they do not occur. Each infection of COVID-19 gradually liquefies the organs. Eventually the entire body will be destroyed. Why prior respiratory viruses did not do this remains unclear, but COVID-19 is clearly the worst thing that has ever happened to human beings, and so now it is true.

Want proof? To date there is not a single person who has survived over 100 COVID-19 infections. Knowing that fact keeps me awake at night. I stare at the ceiling fan spinning slowly, thankful I cannot feel the breeze on my face, as I'm wearing my n95.

Vaccination is important. But experts have not stressed the importance of boosting in perpetuity. Current booster strategies allow four or five months between doses. This is far too long. Boosters should be given continuously, as part of an IV drip to maintain efficacy. The technology is already available for a continuous intravenous infusion of a drug product. We just lack political will to make it happen. The defense production act could facilitate a continuous infusion of vaccination.

Of course this is not enough to stop recurring COVID-19 infections destroying all of human civilization. You have to pair this with dramatic restrictions on movement, and air flow. You have to entirely reimagine society. People should be kept apart as much as possible. Only allowed together for the briefest human interactions. Reproduction can occur inside of test tubes. Pleasure should only be experienced on zoom.

All air is poison until purified through multiple HEPA filters, and cleansed with UV light. Breathing even outdoor air is a risk not worth taking. Houses should be treated like spaceships or undersea laboratories and exchange their own air for risk of exchange.

All people should be fit test daily with a reusable elastometric respirator. Changes in facial structure that come from starvation in the new world where life centers on COVID-19 and economic activity cannot occur may change facial structures, making masks slip. That's why fit tests need to be up to date.

Everytime the virus replicates, it is another opportunity to mutate. Similarly, every time there is another human being, it is another mucous membrane able to contract COVID-19. It's time to stop all replication. I regret my earlier thoughts on reproduction in test tubes. The more elegant solution is to cease all replication.

COVID-19 is the worst thing that's ever happened to people. Our ancestors never experienced anything worse. Our whole lives should change in perpetuity around it. It doesn't matter how low the IFR gets, we should reorganize all of society around this problem. Masking has no downsides. Never has, never will. Ergo, it should continue indefinitely. Banning large gatherings has no downside either. Finally, human interactions have always been superfluous. It's time to recognize that.

If we don't do this, we have no idea if the 4th or 5th COVID-19 infection will literally liquefy our organs. Without knowing this fact, it is reckless and cavalier to continue along our path.

The real COVID-19 experts— those with siren emojis in their profile, those whose profile pic are still masked, and those who have never left their house-- understand the stakes of what we are dealing with. The fate of civilization hangs in the balance. If we follow the path we are on, we will all liquefy. If we do everything I ask, civilization will also end because, as I mentioned, reproduction is another opportunity for the virus to spread, and the entire economic system will collapse. But that is a small price to pay for safety.


Dr Wiseman is the author of numerous mathematical models that show everything he is saying is correct. He also consults for a testing company, which has done elegant work to show we need to test every day forever. He also has access to a VA data set that has proven long COVID is the worst thing that's ever happened in a series of 25 papers. They always use different controls, but for good reason.
Question time is over.
 

Heliobas Disciple

TB Fanatic
(fair use applies)

Are causality assessments being done by CDC or WHO?
FOIA request says NOPE.
Jessica Rose
16 hr ago

Once upon a time there was a recent FOIA request made that led nowhere. No! This isn’t the story of the PRR! This is another story of a nowhere lead. It seems to be par for the course these days, doesn’t it? Thanks to all the hard-working people requesting this information via FOIA, and also to all of the people trying to find the requested information in the piles of well, nothing. I guess it’s not that hard to sift through nothing.

Background

There are two documents that mention assessment of causality using adverse event data: “Causality assessment of an adverse event following immunization (‎AEFI)‎: user manual for the revised WHO classification, 2nd ed., 2019 update” (World Health Organization (WHO)) and theStandard Operating Procedures" (SOP) document updated Jan 29, 2021” (Centers for Disease Control (CDC)).

Acronyms to know:
  1. FOIA: Freedom of Information Request
  2. AE: Adverse Event
  3. AESI: Adverse Event of Special Interest
  4. AEFI: Adverse Event Following Immunization
  5. SOP: Standard Operating Procedures
  6. CDC: Centers for Disease Control
  7. WHO: World Health Organization
CDC - The latter has a description of causality assessment protocol that goes like this:

2.0 Overview of VAERS Surveillance Activities
The specific tasks and frequency of these tasks for surveillance will be adjusted to meet public health needs, with consideration of staff time and resources. For example, in the event of a significant increase in the number of adverse events (AEs) reported to VAERS that warrant clinical review, additional ISO staff will be assigned to perform reviews. An algorithm of the process to monitor vaccine AEs is shown in Appendix 4.1.
CDC will perform clinical reviews for AESIs listed in Table 1. Results from automated data assessment will identify additional conditions potentially warranting further clinical review.

Table 1 includes the following AESIs: Acute myocardial infarction (AMI), Anaphylaxis, Appendicitis, Bell’s Palsy, Coagulopathy, COVID-19, Death, Guillain–Barré syndrome, Kawasaki’s disease, Multisystem Inflammatory Syndrome in Children (MIS-C), Multisystem Inflammatory Syndrome in Adults (MIS-A), Myopericarditis, Narcolepsy/Cataplexy, Vaccination during pregnancy, Seizure, Stroke, Transverse myelitis. Pretty short list, but alright.

Thus, it is written in this document updated on January 29, 2021, that the AEs listed above would be clinically-reviewed by the CDC to identify conditions warranting further review, ie: causality assessment.

For my splendid readers, the VAERS reports without considering an Under Reporting Factor (URF) (as of July 1, 2022) are as follows. These counts are bound to be drastically underestimated (due to many factors such as multiple MedDRA codes for the same AE), and do not forget the URF. I have added the AE counts as they would be with an URF of 31 in brackets (URF of 10 for death) as well. Check out COVID-19.
  1. Acute myocardial infarction (AMI): 6,090 (188,790)
  2. Anaphylaxis: 9,526 (295,306)
  3. Appendicitis: 1,560 (48,360)
  4. Bell’s Palsy: 6,582 (204,042)
  5. Coagulopathy: 516 (15,996)
  6. COVID-19: 608,213 (18,854,603) - This is ironic, Alanis. Why don’t you sing about this? By the way, this is #1 reported AE in VAERS currently.
  7. Death: 32,671 (w/URF 10 = 320,671)
  8. Guillain–Barré syndrome: 2,319 (71,889)
  9. Kawasaki’s disease: 46 (1,426)
  10. Multisystem Inflammatory Syndrome in Children (MIS-C): 90 (2,790)
  11. Multisystem Inflammatory Syndrome in Adults (MIS-A): 22 (682)
  12. Myopericarditis: 37,803 (1,171,893)
  13. Narcolepsy/Cataplexy: 178 (5,518)
  14. Vaccination during pregnancy: 9,674 (299,894)
  15. Seizure: 14,303 (443,393)
  16. Stroke: 16,520 (512,120)
  17. Transverse myelitis: 325 (10,075)
Appendix 4.1 is a schematic of the algorithm meant to be implemented to do these assessment and reviews as shown in Figure 1. You’ll note in red that the assessment of listed AESIs is part and parcel as part of the steps in the algorithm.

You’ll also notice that the PRR signal is meant to be measured here. We all know by now that they also are not assessing the PRR thanks to that other FOIA request.


Figure 1: Table 4.1 Process of monitoring of COVID-19 vaccine adverse events. https://www.cdc.gov/vaccinesafety/pdf/VAERS-v2-SOP.pdf. Page 20.

WHO - The former has a description of causality assessment protocol that is quite thorough. If you click on the link above, you’ll see that it takes you to a book! A book written about how to assess causality from adverse events. It is quite thorough! They define an AEFI as the following:

Adverse event following immunization (AEFI): This is defined as any untoward medical occurrence which follows immunization and which does not necessarily have a causal relationship with the use of the vaccine. The adverse event may be any unfavourable or unintended sign, an abnormal laboratory finding, a symptom or a disease.

They describe therein how to make these assessments both at the individual and the population levels. This is done using several of the Bradford Hill Criteria such as Temporality, Dose response and biological plausibility as shown in Figure 2.


Figure 2: 6 of the 10 Bradford Hill Criteria for assessment of population level causality likelihood. Causality assessment of an adverse event following immunization (‎AEFI)‎: user manual for the revised WHO classification, 2nd ed., 2019 update. Page 9.


Causality assessment usually will not prove or disprove an association between an event and the immunization. It is meant to assist in determining the level of certainty of such an association. A definite causal association or absence of association often cannot be established for an individual event.

Yes. It is meant to assess whether or not a biological product is doing harm to the public or subpopulations of the public.

That’s what pharmacovigilance tools like VAERS are for: they represent the epidemiological data set from where the AEFIs are gathered.


Figure 3: This is how they pick the AESIs to assess. Causality assessment of an adverse event following immunization (‎AEFI)‎: user manual for the revised WHO classification, 2nd ed., 2019 update. Page 15.

As of July 1, 2022, in the context of AEs associated with COVID-19 injectable products reports filed in VAERS without considering an URF (URF 10 or 31), there are 32,671 (320,671 - URF 10) deaths, 30,933 (958,923) life threatening reports, 287,731 (8,919,661) hospitalizations, 51,438 (1,594,578) disabilities, 472 (14,632) birth defects reported, 312,839 (9,698,009) severe AEs reported, 63,795 (1,977,645) reports of hepatological AEs, 46 (460 - URF 10) Creutzfeldt-Jacob disease (CJD) reports, 4,554 (141,174) reports of spontaneous abortion, 25,910 (803,210) reports of diabetes, 26,402 (818,462) reports of cancer, 37,803 (1,171,893) reports of myocarditis and 79,936 (2,478,016) reports of thrombotic AEs, just to name a few clustered cases in VAERS. By the way, that CJD count is above the background reporting rate for the year. It is very concerning.

I think we have a Case.

The following is a screenshot of the WHO Causality assessment algorithm schematic on page 36 of Causality assessment of an adverse event following immunization (‎AEFI)‎: user manual for the revised WHO classification, 2nd ed., 2019 update, that was sent with the FOIA request.


Figure 4: Causality assessment algorithm of the WHO. Causality assessment of an adverse event following immunization (‎AEFI)‎: user manual for the revised WHO classification, 2nd ed., 2019 update. Page 36.

Just so everyone knows, they have used (and do use) VAERS data as the source data for this causality assessment protocol, in the past. In the example in Figure 5, they found no causal link between MMR shots and death reports in VAERS for kids.

Of course they didn’t. That would halt the program.


Figure 5: Causality assessment of VAERS death associated with MMR. Causality assessment of an adverse event following immunization (‎AEFI)‎: user manual for the revised WHO classification, 2nd ed., 2019 update. Page 24.

So the FOIA request itself is valid, in my opinion. Here is the FOIA request letter.


Figure 6: The FOIA request made June 22, 2022.

Here is the expedient reply from the Department of Health and Human Services.


Figure 6: The FOIA request response made July 5, 2022.

I can imagine that there might be some crafty word play at play here to side-step disclosing the information requested in the request. Or perhaps the request should have been more specific? Or less specific? Or perhaps the inclusion of the algorithm itself was a mistake? Or perhaps specifically requesting this causality assessment using VAERS data was the mistake? It is noteworthy, however, that the word ‘or’ was used to imply that the search should be made pertaining to both documents separately, but perhaps since the causality algorithm itself is associated with the WHO and not the SOP, it might understandable that they came up with nothing… ?

But still.

WHO’s doing the causality assessment? (Get it?)

Notice, that they did point the FOIA requester to the VAERS website to remind said requester that VAERS isn’t actually used for anything useful and remains the duck decoy for the fact that vaccine companies remain liable-less.

.
 

Heliobas Disciple

TB Fanatic
(fair use applies)

END STAGE COVID IS ASHERSON'S SYNDROME - EARLY COVID MIMICS CHURG-STRAUSS: MY WORK FROM DECEMBER 2020
Jessica Rose's recent post has renewed my concerns that Catastrophic Antiphospholipid Syndrome may be the result of multiple infections/exposures to the Spike Protein of SARS-CoV-2
Walter M Chesnut
5 hr ago

The recent post by Jessica Rose regarding molecular mimicry has caused me to revisit one of my earliest hypotheses about COVID and the Spike Protein. Before I began posting on Twitter and Substack, I corresponded with several MD/PhDs around the world. I hypothesized that the immense peptide sharing of the Spike Protein would induce a progressive autoimmune disease which would inevitably result in Asherson’s Syndrome (Catastrophic Antiphospholipid Syndrome) for all over time, due to reinfections and exposures to the Spike Protein. I still believe, unfortunately, it is the case.

Jessica’s work, combined with a paper I found, has prompted me to share these initial theories and concerns.

This to me is extremely alarming, and provides evidence for my hypothesis:

Catastrophic antiphospholipid syndrome complicated with essential thrombocythaemia after COVID-19 vaccination: in search of the underlying mechanism

Catastrophic antiphospholipid syndrome complicated with essential thrombocythaemia after COVID-19 vaccination: in search of the underlying mechanism

I believe I have already discovered the underlying mechanism.

Please read the email I sent to an MD/PhD back in December of 2020, at the beginning of the rollout.





 

Heliobas Disciple

TB Fanatic
(fair use applies)

Even when one realizes that SARS-CoV-2 is a bioweapon, the rest of the story still does not make sense
So I turn to you dear reader to help fill in the gaps
Toby Rogers
4 hr ago

Jeffrey Sachs is the most esteemed economist of his generation. Hired by Harvard at the tender age of 26 he became a full professor with tenure at 28. Whoa. Over the last 40 years Sachs has had a hand in many of the biggest economic projects in the world — crushing inflation (and civil society) in Bolivia, advising the Russians on the transition to capitalism, crafting Millennium Development Goals for the U.N., and running the Earth Institute at Columbia.

(For the record, Jeffrey Sachs blocked me on Twitter back in 2013 when I pointed out that he screwed up the transition to capitalism in Russia and created the mafia oligarchs who had already begun to destroy the world).

Jeffrey Sachs is the ultimate insider, the golden boy that capital can always turn to in order to make things right so that they can return to conquest (while feeling great about it).

So of course The Lancet named Sachs to head its blue ribbon commission to look into and cover up the origins of SARS-CoV-2.

Well, apparently the lies about SARS-CoV-2 were too much even for Dr. Sachs and at a recent conference he revealed that the best evidence points to SARS-CoV-2 originating from a bio(weapons) lab — IN THE UNITED STATES!

Like the horror movie cliché, the call is coming from inside the house.

Arnaud Bertrand @RnaudBertrand
Wow
1f62f.svg
Prof. Jeffrey Sachs: "I chaired the commission for the Lancet for 2 years on Covid. I'm pretty convinced it came out of a US lab of biotechnology [...] We don't know for sure but there is enough evidence. [However] it's not being investigated, not in the US, not anywhere."

(Hilarious that he does the perfect impression of the chin stroke emoji in the clip. )

The full clip is (here) — the relevant portion begins at 12:24.

Sachs is presumably referring to the Baric Lab at the University of North Carolina but there could be many other suspects.
This is a massive story — literally the story of the century — that the mainstream media will completely ignore and censor as they have done with nearly all important news since the start of the pandemic.

But even with this massive revelation, the story of the origins of SARS-CoV-2 still does not add up. So I turn to you today not with answers but with questions. I have some of the pieces but I’m asking you to help fill in the rest.

First principles: As I have pointed out before, there are a quadrillion x quadrillion viruses in the world (more viruses on earth than stars in the universe). We know a little something about a few hundred of them. There is absolutely no reason to create more viruses. Gain-of-function research (to make viruses more lethal) is always bioweapons development. It has no civilian purpose. It has never produced a usable human product.

Like most developed countries, the U.S. has a massive bioweapons program. During the Cold War it focused on countering or perhaps conquering the Soviet Union. As Kris Newby reveals in the absolutely brilliant book Bitten: The Secret History of Lyme Disease and Biological Weapons — U.S. bioweapons labs were keenly focused on using fleas, ticks, and mosquitos to transmit gain-of-function viruses and bacteria to kill our enemies. The U.S. military tested the delivery mechanisms for these weapons (including the use of fog machines mounted on ships) on the U.S. population. The book presents fairly convincing evidence that the spirochetes that cause Lyme Disease originated in a U.S. bioweapons lab and somehow escaped into the population (not a big surprise because leaks often happen at these labs).

We know that the Obama Administration banned gain-of-function research in 2014. We also know that there was still money in the NIAID pipeline that had not been spent so Fauci laundered it through the EcoHealth Alliance to the Wuhan Institute of Virology (WIV). We know that WIV was splicing pieces of HIV into bat coronaviruses.

If SARS-CoV-2 originated in the U.S., which lab did it come from?

If SARS-CoV-2 originated in the U.S., when was it invented and did the inventors violate the ban on gain-of-function research?

If SARS-CoV-2 originated in the U.S., how did it first infect humans? Who was patient zero?

If SARS-CoV-2 originated in the U.S., how did it get to Wuhan, China? And why only Wuhan at first?

Meanwhile similar gain-of-function research was also going on in China as funded by the U.S. If this research was already happening in the U.S., why also fund it in China? And why China — literally our biggest military adversary? U.S. Department of Defense, DARPA, and BARDA surely knew about this project and signed off on it.

So the U.S. and China are allies now? And the enemy is… us?

Why did the French help build the bioweapons lab in Wuhan?

France and China are allies now? And the enemy is… us?

This is by far the biggest act of treason in U.S. history. Politically, this is a fat slow pitch right over the middle of the plate.

Yet only two national-level Republicans — Ron Johnson and Rand Paul — know how to hit this pitch??? What on earth.

If Republicans ran on this (as they did in connection with an ill-advised press release after four Americans were killed in Benghazi) they could sweep nearly every Congressional seat in the midterm elections. One might think that the opposition party would be interested in making hay out of this situation. Yet the Republican party bosses are SILENT on the fact that the highest paid federal bureaucrat in D.C. killed 1 million Americans and 6 million people worldwide?

What on earth is going on?

Republicans and Democrats are allies now? And the enemy is… us?

As you can see, I’m out of answers, so I’m looking for someone to explain it to me. I dislike conspiracy theories because they are usually unnecessary — if you just follow the money you can usually figure out what happened and create the leverage for criminal convictions or revolution. In this case, we just have scattered fragments of the story. 27 months into the pandemic, no government agency, public health official, nor media source is the slightest bit curious about how it all started. This is the ultimate “dog that didn’t bark.”

I’m hoping that one of you can make it make sense because I cannot.

Sachs will likely be forced to walk back his statement by the end of the week but the cat is already out of the bag (download the video before Google deletes it).

Blessings to the warriors.

Prayers for everyone fighting against Pharma fascism.

In the comments, please share your thoughts on what is going on. Links are appreciated. Who is doing the best work on these questions?

As always I welcome any corrections.
 

Heliobas Disciple

TB Fanatic
(fair use applies)

Repeated Reinfections, VAIDS & The Slow Kill Democide
2nd Smartest Guy in the World
19 hr ago

An important research study entitled Sharing CD4+ T Cell Loss: When COVID-19 and HIV Collide on Immune System correctly associates COVID-19 with AIDS by comparing host characteristics and hyper-inflammatory responses between the patient groups’ respective CD4+ T cell counts.

This is the critical chart in the study:



What is being depicted in the above is CD4+ T cell dysfunction in all three groups. But unlike HIV-1, which is a one and done infection, COVID-19 infections may be contracted many times over as we have witnessed in the DEATHVAXXED™ demographics, with more doses equating to more depleted immune systems.

Also, unlike the HIV-1 group and the Severe COVID-19 group which as per the chart does not experience a CD4+ T cell rebound due to mortality (and “treatment” protocols), the Mild COVID-19 group does over time experience a rebound effect, and at around 10 months pre-infection baseline CD4+ T cell homeostasis is restored.

The study concludes:

Both HIV-1 and SARS-CoV-2 infection share CD4+ T cell loss in association with disease outcome and immunodeficiency. Direct attacks on CD4+ T cells, immune activation and redistribution of CD4+ T cell are contributing mechanisms in very different proportion for CD4+ T cell lymphopenia in both diseases. […] Overall, experience in HIV clinical management and past clinical trials represent a special use case for innovative studies aiming at increasing CD4+ T cell function and reducing COVID-19 morbidity.

This is why in some cases COVID-19 causes AIDS-like CD4+ T cell depletion, but in all cases the DEATHVAX™ induces VAIDS as a direct function of the Pseudouridine component of the Modified mRNA injection causing potentially unlimited endogenous Spike Protein production.

But what happens when the VAIDS sufferer is exposed to a COVID-19 variant may very well be the most important yet unmentioned part of the study.

From an anonymous email tipster:

If Ba5 causes 2 infections per vaxed person over 4 months, they’ll lose as much as 10% net of their immune system.
If Ba2.75 which is 9 times as contagious does the same thing come fall, the vaxed who are infected twice by it as well, will lose another 10% of their immune system.
Heading into winter cold and flu season their systems will be at least 20% less effective, not counting damage from the vax.
The combined repeat infections (even though mild), will leave their immune systems unable to fight off normal winter viruses that will turn into pneumonia.
It WILL BE A HORRIBLE WINTER due to the cumulative effects of the many variants and the Vaccine.

Therefore, HIV-1 and VAIDS sufferers alike are at heightened risk for death upon exposure not just to a COVID-19 “variant”, but to even to a coronavirus common cold.

Remember, before PSYOP-19 it was scientific cannon that asymptomatic spread is impossible, and there is no cure for the common cold (i.e. coronavirus). Both of these statements to this very day still hold true.

Here is what a chart of reinfection for the DEATHVAX™ boosted demographics may look like:



The common cold and your average flu become exceptionally deadly when the CD4+ T cell count is low enough. This is why historically AIDS patients were so susceptible during each flu season, and pneumonia deaths would spike during the winters.

The bioweapon-injected VAIDS sufferers that may “feel” fine today could very well be experiencing a hellacious Winter 2022.

And Dr. Mengele 2.0 aka Dr. Fauci, BigPharma, the CIA, CDC, WHO, UN, WEF et al. always knew this would transpire. They also knew that the Spike Protein represses the p53 protein which in turn represses cancer and tumor development, and that cancer rates would surge a la AIDS sufferers.

The very same virologists that could not come up with an AIDS vaccine after four decades and hundreds of billions of stolen via taxation dollars of funding somehow miraculously came up with an mRNA COVID-19 vaccine seemingly overnight. The same mRNA technology that in all animal trials had such grim outcomes that there was never any hope of ever making it to human trials.

So here we are now, on the precipice of the next “pandemic” in PSYOP-22 which will invariably involve never-ending boosters which in turn will continue to decimate CD4+ T cell counts of the Genetically Modified Humans that continue to subject themselves to this eugenics program.

We are also seeing Accelerating Alzheimer’s disease (AAD), birth rates plummeting across all highly “vaccinated” nations, and more and more life insurance companies reporting 40% increases in all-cause mortality, and so on and so forth.
And if that were not enough, there is now evidence that the Spike Protein causes Accelerating Cell Aging ( acronym du jour: ACA) for Rapid Aging Process (and another acronym du jour: RAP), which essentially gibes with this substack’s thesis that lifespans are greatly shortened by all of those subjecting themselves to indefinite endogenous Spike Protein increases via the deadly injections; to wit:

Image
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Heliobas Disciple

TB Fanatic
(fair use applies)

NEW - Vaccinated Toddlers In Pfizer’s Trial Were More Likely To Get Severely Ill With COVID Than Those Who Received A Placebo
2nd Smartest Guy in the World
13 hr ago

Another day, another MSM whitewash story.

Crimes against children is the most pernicious subset of crimes against humanity.

And one of the most criminal corporations in the history of corporations has been exposed yet again for their PSYOP-19 depopulation and control program.

Today’s coverup is brought to us courtesy of The Wall Street Journal:

Covid was clearly a health emergency for adults in 2020. By contrast, the urgency now feels political.

No, COVID clearly was never a health emergency. COVID policy was and continues to be the global emergency. The urgency then and now is “political” insofar as the One World Government’s agenda is disguised as kabuki theater “politics”.

‘This is a very historic milestone, a monumental step forward,” President Biden declared last week after the Food and Drug Administration authorized Pfizer and Moderna vaccines for toddlers. “The United States is now the first country in the world to offer safe and effective Covid-19 vaccines for children as young as 6 months old.”
In fact, we don’t know if the vaccines are safe and effective. The rushed FDA action was based on extremely weak evidence. It’s one thing to show regulatory flexibility during an emergency. But for children, Covid isn’t an emergency. The FDA bent its standards to an unusual degree and brushed aside troubling evidence that warrants more investigation.

The reality inversion coverup is egregious. Irrespective of what the adult soiling ice cream eating pedo puppet POTUS mindlessly reads off the teleprompter, we know with 100% certainty that these slow kill bioweapons are unsafe and ineffective at their stated acquired immunity claims. But we also know with 100% certainty that the DEATHVAX™ is exceedingly effective at unsafe.

The hack writing this article partially lets the veil slip:

More troubling, vaccinated toddlers in Pfizer’s trial were more likely to get severely ill with Covid than those who received a placebo. Pfizer claimed most severe cases weren’t “clinically significant,” whatever that means, but this was all the more reason that the FDA should have required a longer follow-up before authorizing the vaccine.

The author of this travesty of reportage as well as the Wall Street Journal are clearly aiding and abetting the Cult in their crimes against humanity.

It is safe to assume that the bulk of The Wall Street Journal’s advertising revenues derive from Pfizer and the other BigPharma criminal corporations.
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Heliobas Disciple

TB Fanatic
(fair use applies)

'It's the economy, stupid', was coined by Bill Clinton in 1992; well, 'It's the vaccine, stupid', it is the COVID injection itself that causes infections, re-infections, hospitalizations, death (ADED)
"It's the COVID vaccine, stupid", the non-neutralizing vaccinal antibodies (induced by the vaccine) cannot eliminate the virus, but binds to it, enhancing infectiousness to vaccinee, and re-infection
Dr. Paul Alexander
16 hr ago

It is the COVID injection that is causing infection for the first time or re-infection (due to potential antigenic shift as their is massive population level mounting immune pressure on the spike antigen) and getting the vaccinee very sick. Yes, it is the COVID injection that is driving infection in the vaccinated and potential morbidity and mortality. It is not the virus. It is the properties given to the virus by the vaccine.

If you continue to place immune pressure on the virus without being able to sterilize, neutralize it, then you will cause fitter more infectious and more virulent variants to emerge as they are doing now.

We warn again, if the COVID vaccine is not stopped, it will select for not just an infectious variant, but a virulent lethal one too, causing more serious disease. Both infectious and lethal. It may be too late and this may be happening now with BA.5. The COVID vaccine will do this. Stand by, you will see what we mean. It is so very dangerous what these governments and vaccine makers have done, they know what they are doing and the nightmare they are causing, for in reaction, you ask for more vaccine. They get more money and power. You remain complacent and you acquiesce and stop thinking. You are about to deliver your child onto the altar of vaccine profits.

The key is to reduce the infectious pressure in the population and we can do that by not taking more vaccine, that is an insane step for it is the COVID vaccine that is contributing to the increased infection in the vaccinated. No, no vaccine, but rather it is the use of antiviral chemoprophylaxis to supplant mass vaccination in order to reduce infection and thus the immune pressure. You are seeking to reduce the numbers of virus available for binding with the infection facilitating vaccinal Abs. If you do not do this, then the vaccine must be stopped. One or the other, for if neither is stopped, then this pandemic will go on for 100 more years. I argue the vaccine developers and the public health officials in US, Canada etc. are not that stupid, cannot be that inept to not know what I just wrote above. Or are they? So in some manner, one may argue this is deliberate.

You are taking a COVID vaccine based on the initial legacy Wuhan strain that has not existed for a very long time, displaced by other variants and today we know it is Omicron and we are up to BA.4 and BA.5 as the dominant clades/sub-variants. Thus they are all lying to you, including your doctor that is giving you the shot. They know it cannot work, that all it will do is spike the antibodies that then wane rapidly, and all it does is reduces mild symptoms. The evidence is clear that the vaccinal antibodies are non-neutralizing and the virus is resistant to it. Yet the sub-optimal immune pressure by the vaccinal antibodies on the spike is causing the fittest most infectious variants to be selected and to escape the pressure. You have massive infectious pressure bumping up against mounting sub-optimal immune pressure that drives selection of more infectious and potentially more lethal variants.

The evidence tells us that it is not the virus that is infectious, it is not a property intrinsic to the virus, but it is the binding to the virus by the non-neutralizing antibodies that cannot eliminate the virus yet can still bind to it, that is giving it that property. The vaccinee is now at great risk of infection or re-infection and we argue that morbidity and mortality is rising due to this. It is the non-neutralizing vaccinal antibodies that is key cause of this and if we want this pandemic to continue for 100 years with infectious variant after infectious variant to emerge, then we keep vaccinating the very same way.

Change nothing. And if you told me they will next change the spike to match BA.4 and BA.5, well by the time that comes, there will be new variants and again, you will be vaccinating ‘into’ a pandemic with high infectious pressure and with vaccinal antibodies that do not match the prevailing circulating virus and thus sub-optimal non-neutralizing immune pressure will mount coming up from the population.

The result? The same thing as now. More infectious and potentially lethal variants. The vaccine is causing the infectiousness. There is also original antigenic sin (OAS) where the Abs recall is to vaccine-primed anti-Spike Abs. It is the current vaccine that is contributing to the elevated infectious pressure as it is causing the vaccinated to become infected.
We are at risk now of antibody dependent enhancement of disease (ADED), akin to ADEI (antibody dependent enhancement of infection, sometimes referred to as antibody mediated viral enhancement).

It is either we stopped this failed vaccine or we reduce the infectious pressure in the environment. The vaccine is driving the infectious pressure so by stopping it, the pressure goes down and the sub-optimal vaccinal antibodies will have less virus to place under pressure and thus reduced risk of viral evolution. There will be less virus for the non-neutralizing vaccinal antibodies to bind to.

You are creating disaster if you think of the virus alone. You are clueless then. No, it is the interplay, the interaction within the viral-host ecosystem, that is striving to achieve ‘balance’, or equilibrium, that is going on between the virus and the host immune system at a population level, with the non-neutralizing vaccinal antibodies being a central player. The host has to find a way to cut the chain of transmission.

Those who have been vaccinated are in a unique situation of risk. We warn, do not touch the children with these injections.

see my prior stack too on why children must not be vaccinated with these COVID injections:

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Heliobas Disciple

TB Fanatic
(fair use applies)

Catastrophic COVID vaccine failures stem from moronic inept idiots at Pfizer & Moderna & CDC & NIH & PHAC etc. not grasping that vaccinating 'outside' versus 'inside' a pandemic is not the same thing
The idiots fail to center potent 'viral-host' immune system ecosystem in any decisions; it's the non-neutralizing vaccinal antibodies exerting pressure on spike (receptor binding or N-terminal domain)
Dr. Paul Alexander
15 hr ago

It is the non-neutralizing vaccinal antibodies that do not neutralize the virus and thus we do not stop transmission. If you think vaccinating into a pandemic is the same as outside of a pandemic, then you have no clue what you are doing. The immune pressure on the virus and the infectious pressure on the population is not the same for either. These idiots at CDC, NIH, FDA, NIAID, PHAC, SAGE, Health Canada have shown us they have no idea, coupled to Moderna and Pfizer criminals like Bourla for IMO, they are.

If these very inept incompetent vaccine developers, and these fools at CDC and NIH and Health Canada and PHAC who gave the immune system ONE target to begin with, just one ‘spike’ target that doomed the roll out, at the gates, go and bring a second generation COVID vaccine e.g. a bivalent omicron and Wuhan spike vaccine, and only tinker with the spike and do not change any conserved sites e.g. the N-terminal domain, the nucleocapsid protein etc. , then these stupid idiots will cause several issues that will doom any second generation vaccine:

1)they will once again be vaccinating ‘into’ a pandemic with massive infectious pressure

2)will fail again to understand the potent role of the virus-host immune system interplay that is driving variants

3)fail to understand the devastating input of placing sub-optimal immune pressure on the target antigen that will result in variants AGAIN

4)by the time they bring the changed vaccine, new variants would be on deck and the vaccine would be worthless, like how the Wuhan spike vaccine antibodies are worthless to omicron spike virus today

Again, based on all we see, these vaccine developers and technocrats at CDC and NIH etc. are doing this deliberately, this pandemic will go on for 100 years and kill many many people.
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naegling62

Veteran Member
I don’t know how you keep up with all these articles!
My eyes started to cross weeks ago
Yes, and you know the doctors aren't investigating any of these articles. I know this from personal experience of my doctor relative. They are among some of the most closed minded people I know.

Here's a fun fact. So at my recent visit with my endocrinologist, he noted that my Vit D levels were 74. He told me to stop taking D that all his patients were D deficient. What? Hey doc, here's a clue, most of the folks in ICU are morbidly obese and D deficient.
 

Tristan

TB Fanatic
(fair use applies)

Disney Employees Suing Company Over Vaccine Exemption Refusals
By Jackson Elliott
July 5, 2022

The Walt Disney Company punished and then fired three longtime employees because they refused the COVID-19 vaccine on religious grounds, according to a new lawsuit against the company.

On July 30, 2021, Disney announced that its employees would have to take one of the several COVID-19 vaccines to continue working with the company.

When Florida’s government forbade “vaccinate or terminate” policies, the company began a relentless push to vaccinate all employees, including those who had requested religious exemptions, the lawsuit states.

According to the plaintiffs, Disney burdened religious vaccine objectors with restrictions that went beyond its original pandemic policy.

“The mask, face shield, and distancing from cast and guest were clearly punitive measures designed to destroy my health, segregate me, harass, discriminate, and intimidate me into taking an experimental vaccine,” said Adam Pajer, one of the suing employees.

Religious Objections

Pajer, Barbara Andreas, and Stephen Cribb were longtime Disney employees.

Pajer worked at Disney for seven years and had some leadership responsibilities.

Andreas had worked there for 21 years and in leadership for 17 years.

Cribb was at the company for 11 years and received the Walt Disney Legacy Award, its highest award for park employees.
All refused to take a COVID-19 vaccine, citing religious objections.

Pajer said he believed he had a religious obligation not to harm his body and that the vaccine was harmful; Andreas objected to covering her face and the contamination of her blood by vaccine ingredients for religious reasons; and Cribb objected because he believed the Jansen, Moderna, and Pfizer vaccines were made using cells from aborted babies.

But instead of accepting these exemption requests, Disney pushed back. All three found the company was slow to respond to their requests, leaving them wondering about the position of their jobs.

When Disney finally responded, the employees faced interrogative interviews.

“[A Disney employee] proposed hypothetical questions to Ms Andreas, such as whether she would consent to a vaccine that did not contain aborted fetal cells. Ms Andreas was very uncomfortable about such an inappropriate line of questioning regarding her sincere religious beliefs,” the lawsuit reads.

Cribb said management asked him to abandon his religious convictions on the vaccine because the FDA approved it.

Pajer said managers yelled at him and lit a written statement about the discrimination he faced while he was still holding it.

Eventually, Disney denied religious exemptions to all three employees. It also refused to speak with their lawyers.

In Cribb’s case, “Counsel requested that Disney direct correspondence directly to him, and Disney flatly refused,” the lawsuit said.

Employees who refused to take the vaccine faced a series of restrictive safety measures that they argued amounted to coercion.

The unvaccinated employees said they had to wear masks while outside, wear N95 masks with “Warning” written on the front, eat in segregated areas, and not take off their masks even for a moment.

The company called for intrusive measures to test whether masks worked too. A technician sprayed a mist in employees’ faces, according to the employees’ lawyer.

Employees said that wearing a mask outside all day is stuffy and grueling in Florida’s intense heat. But Disney management showed little mercy.

Targets for Bullying

“I was accused of pulling a mask away from my face just to catch my breath after being forced to wear it for the entirety of my shift, inside and outside, when other cast had the choice not to wear them at all,” said Pajer.

Disney didn’t provide separate areas where unvaccinated employees could get lunch.

At the same time, Disney had ended outdoor mask mandates for unvaccinated guests.

The lawsuit said that pictures and videos during a 2022 outdoor Mardi Gras event showed that Cribb was likely the only person among hundreds of employees and guests at the resort wearing a mask.

“He was overwhelmed by the humiliation of Disney’s overt discrimination,” the lawsuit reads.

According to Andreas, these measures singled out unvaccinated employees and made them targets for a bullying campaign.

Epoch Times Photo Even after Disney allowed guests in without unmasked and unvaccinated, staff faced continued COVID-19 restrictions.

“We became the subject of harassment by other cast members and guests once the PPE provided a visual display of our private information,” she said.

The lawsuit said that these restrictions resembled what Disney demanded of COVID-19-exposed staff before the vaccines became available.

“The augmented protocols now suddenly enforced on plaintiffs consisted of harsh isolation and restrictions, causing serious breathing problems for plaintiffs, and making it nearly impossible to find a compliant manner and location in which to eat or drink while on shift,” the lawsuit reads.

Fired for Faith

Finally, Disney fired all three employees for refusing to take the vaccine.

“My dream-come-true became a total nightmare,” said Cribb.

“Suddenly, the same organization that had captivated my imagination in childhood with its one-of-a-kind magical appeal revealed its true self—a corporate machine bent on pursuing financial and political ends at any cost.”

The three employees filed a joint lawsuit against Disney for taking retaliatory action because employees filed religious discrimination claims.

The trio asked the court to reinstate their employment, end Disney’s enforcement of discriminatory protocols, and pay each plaintiff back for lost wages, lost benefits, attorney fees, and any other required relief.

“Disney is not above the law. Their actions in the past month have shown the public that Christians have no place in their parks or on their payroll,” said Andreas.


Duck Fisney.
 

Tristan

TB Fanatic

Tristan

TB Fanatic
Yes, and you know the doctors aren't investigating any of these articles. I know this from personal experience of my doctor relative. They are among some of the most closed minded people I know.

Here's a fun fact. So at my recent visit with my endocrinologist, he noted that my Vit D levels were 74. He told me to stop taking D that all his patients were D deficient. What? Hey doc, here's a clue, most of the folks in ICU are morbidly obese and D deficient.


That is because they have been trained to go-to "Trusted Authority", and to actively filter out extraneous information (i.e. be very skeptical of anything else...)

Trouble is, what happens if or when "Trusted Authority" has become co-opted? Or, corrupted?
 
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