MNKYPOX Monkeypox - Consolidated Thread.

jward

passin' thru
Interesting to note that of those Health Care Workers infected, many, but not necessarily all, were adjudged to have acquired their infections "in the community" which seems to suggest via the usual transmission venues of parties or large events, and not via their occupational endeavors. :: shrug :: Also repeat that transmission is skin to skin contact, but rectal swabs and semen samples have been identified as positive as well, and so tis impossible to separate routes of infection out with any confidence.

1663244372386.png
 

SouthernBreeze

Has No Life - Lives on TB
I'm not celebrating, yet. MPX is still on my radar, as is Covid and what I call "Crud."
I will continue leaving my outside shoes in the garage, along with other routines.
They don't take long, and perhaps they will help me to avoid the seasonal flu.

MP will stay on my radar another 2 weeks, unless something major happens to change that. I don't expect there to be anything, and I'm now not too concerned at all. I'm focusing all my attention to trying to prevent us from catching Covid and the seasonal flu. Since me nor any member of my family are HIV positive or immunosuppressed, MP isn't deadly. On the other hand, Covid and seasonal flu can certainly be deadly to anyone.
 

helen

Panic Sex Lady
The article says he was a big fan of C-19 vax too.


Michael Mosher, a Hollywood makeup artist, has died 9 days after receiving a monkeypox vaccine, according to social media posts.

He was reportedly vaccinated for monkeypox on August 25, 2022, and then “died suddenly” on September 3, 2022.

 

Heliobas Disciple

TB Fanatic

more on this:

(fair use applies)


US warns monkeypox could mutate to resist antiviral drug
By MATTHEW PERRONE and MIKE STOBBE
yesterday

WASHINGTON (AP) — U.S. health officials are warning against overuse of the lone drug available to treat monkeypox, saying that even a small mutation in the virus could render the pills ineffective.

The Food and Drug Administration updated its guidance this week for Tpoxx, which has been prescribed to tens of thousands of patients with the virus.

In an online update, FDA officials cautioned that a single molecular change to monkeypox “could have a large impact on the antiviral activity of Tpoxx.” Since viruses are constantly evolving to overcome obstacles to infection, including drugs, regulators stressed that doctors should be “judicious” in prescribing the medication.

Meanwhile, the Centers for Disease Control and Prevention on Thursday said Tpoxx should no longer be given to otherwise healthy adults who are not suffering severe symptoms.

“For most patients with healthy immune systems, supportive care and pain control may be enough,” agency officials said in a statement.

The moves to scale back Tpoxx’s use follow weeks of criticism from HIV advocates and other patient groups who have urged the Biden administration to make the antiviral drug more widely available. Tpoxx is approved for the related smallpox virus, and its use against monkeypox is considered experimental and tightly controlled by federal officials.

Doctors wishing to prescribe the drug must submit an application to the Centers for Disease Control and Prevention, documenting their patient’s need and agreeing to track their results and any side effects. Officials have shipped 37,000 courses of the drug to physicians.

Tpoxx works by targeting a single protein found on monkeypox, smallpox and similar viruses. The FDA said this week that research in labs, animals and people suggests multiple ways in which monkeypox could develop resistance to the therapy.

The update came as federal officials on Thursday expressed cautious optimism about the trajectory of the outbreak, noting that new cases have fallen about 50% since their peak in August.

During a White House briefing, CDC Director Dr. Rochelle Walensky attributed the decline to vaccinations, educational outreach and individuals reducing behaviors linked to spread. The vast majority of U.S. cases have been in men who have sex with men, though officials emphasize that the virus can infect anyone.

Dr. Anthony Fauci, the nation’s top infectious disease official, noted that resistance is always a risk when using antiviral drugs.

“That’s why we’re uncomfortable when you only have a single drug,” Fauci told reporters. He added that a recently launched study of Tpoxx supported by the National Institutes of Health will track signs of mutation that could lead to resistance. The study is expected to enroll more than 500 patients across 60 U.S. sites.

Last month, the Biden administration invoked rare emergency powers to stretch the nation’s limited supply of monkeypox vaccines. And last week a separate declaration expedited the use of experimental tests for the virus.

But no changes were made to allow emergency use of Tpoxx, stoking complaints from groups representing gay and bisexual men.

The U.S. government’s national stockpile contains has more than 1.7 million courses of Tpoxx, originally manufactured for use during a potential bioterrorism attack.

The FDA approved the medication in 2018 under its “animal rule,” which allows approval based on animal data when human testing is unethical or unfeasible. Smallpox was declared eradicated in 1980 by the World Health Organization, ruling out the possibility for human studies.

Even though the drug was approved for smallpox, its effectiveness was measured in monkeys infected with monkeypox, considered a reasonable predictor of smallpox’s effect on humans. Animals receiving Tpoxx survived at higher rates than those on a placebo. But FDA officials have cautioned that results in animals must be confirmed in human testing.

“Without human trials, we don’t know if Tpoxx is beneficial for humans with monkeypox,” FDA commissioner Dr. Robert Califf told Senate lawmakers at a hearing this week.

The CDC reported last week that 3.5% of patients tracked through its Tpoxx program reported side effects, mainly headache and nausea.

The agency has only gotten back about 200 forms from physicians documenting patient’s initial symptoms and results, accounting for less than 1% of the doses shipped since the start of the outbreak.

___
 

DHR43

Since 2001
more on this:

(fair use applies)


US warns monkeypox could mutate to resist antiviral drug
By MATTHEW PERRONE and MIKE STOBBE
yesterday

WASHINGTON (AP) — U.S. health officials are warning against overuse of the lone drug available to treat monkeypox, saying that even a small mutation in the virus could render the pills ineffective.

The Food and Drug Administration updated its guidance this week for Tpoxx, which has been prescribed to tens of thousands of patients with the virus.

In an online update, FDA officials cautioned that a single molecular change to monkeypox “could have a large impact on the antiviral activity of Tpoxx.” Since viruses are constantly evolving to overcome obstacles to infection, including drugs, regulators stressed that doctors should be “judicious” in prescribing the medication.

Meanwhile, the Centers for Disease Control and Prevention on Thursday said Tpoxx should no longer be given to otherwise healthy adults who are not suffering severe symptoms.

“For most patients with healthy immune systems, supportive care and pain control may be enough,” agency officials said in a statement.

The moves to scale back Tpoxx’s use follow weeks of criticism from HIV advocates and other patient groups who have urged the Biden administration to make the antiviral drug more widely available. Tpoxx is approved for the related smallpox virus, and its use against monkeypox is considered experimental and tightly controlled by federal officials.

Doctors wishing to prescribe the drug must submit an application to the Centers for Disease Control and Prevention, documenting their patient’s need and agreeing to track their results and any side effects. Officials have shipped 37,000 courses of the drug to physicians.

Tpoxx works by targeting a single protein found on monkeypox, smallpox and similar viruses. The FDA said this week that research in labs, animals and people suggests multiple ways in which monkeypox could develop resistance to the therapy.

The update came as federal officials on Thursday expressed cautious optimism about the trajectory of the outbreak, noting that new cases have fallen about 50% since their peak in August.

During a White House briefing, CDC Director Dr. Rochelle Walensky attributed the decline to vaccinations, educational outreach and individuals reducing behaviors linked to spread. The vast majority of U.S. cases have been in men who have sex with men, though officials emphasize that the virus can infect anyone.

Dr. Anthony Fauci, the nation’s top infectious disease official, noted that resistance is always a risk when using antiviral drugs.

“That’s why we’re uncomfortable when you only have a single drug,” Fauci told reporters. He added that a recently launched study of Tpoxx supported by the National Institutes of Health will track signs of mutation that could lead to resistance. The study is expected to enroll more than 500 patients across 60 U.S. sites.

Last month, the Biden administration invoked rare emergency powers to stretch the nation’s limited supply of monkeypox vaccines. And last week a separate declaration expedited the use of experimental tests for the virus.

But no changes were made to allow emergency use of Tpoxx, stoking complaints from groups representing gay and bisexual men.

The U.S. government’s national stockpile contains has more than 1.7 million courses of Tpoxx, originally manufactured for use during a potential bioterrorism attack.

The FDA approved the medication in 2018 under its “animal rule,” which allows approval based on animal data when human testing is unethical or unfeasible. Smallpox was declared eradicated in 1980 by the World Health Organization, ruling out the possibility for human studies.

Even though the drug was approved for smallpox, its effectiveness was measured in monkeys infected with monkeypox, considered a reasonable predictor of smallpox’s effect on humans. Animals receiving Tpoxx survived at higher rates than those on a placebo. But FDA officials have cautioned that results in animals must be confirmed in human testing.

“Without human trials, we don’t know if Tpoxx is beneficial for humans with monkeypox,” FDA commissioner Dr. Robert Califf told Senate lawmakers at a hearing this week.

The CDC reported last week that 3.5% of patients tracked through its Tpoxx program reported side effects, mainly headache and nausea.

The agency has only gotten back about 200 forms from physicians documenting patient’s initial symptoms and results, accounting for less than 1% of the doses shipped since the start of the outbreak.

___
Meanwhile, it's rumored that the federal health officials lie. Yes, it appears to be true.
 

Housecarl

On TB every waking moment
Posted for fair use.....

LA County health care worker contracts monkeypox after exposure at job​

By Denise Dador via
KABC logo

Thursday, September 15, 2022 9:40PM

LOS ANGELES (KABC) -- The nation's first case of a health care worker contracting monkeypox after being exposed on the job was reported in Los Angeles County earlier this week.

"We have identified a health care worker with monkeypox who appears to have been exposed to the virus at their worksite," said Dr. Rita Singhal, chief medical officer for the L.A. County Department of Public Health.

Singhal said the local case is one of eight known worldwide involving a health care employee exposed at work. She said the county has consulted the Centers for Disease Control and Prevention about the case.

"Given that the risk for monkeypox for health care workers remains very low, we will continue to message on current infection-prevention control recommendations and in particular the use of appropriate PPE," Singhal said.

On Monday, local health officials announced a Los Angeles County resident with a compromised immune system died from monkeypox. It's believed to be the first U.S. fatality from the disease.


Monkeypox is spread through close skin-to-skin contact and prolonged exposure to respiratory droplets. It can cause a rash, fever, body aches and chills. Relatively few people require hospitalizations and only a handful of deaths worldwide have been directly linked to the disease.

The CDC recommends the monkeypox vaccine for people who are a close contact of someone who has disease; people who know a sexual partner was diagnosed in the past two weeks; and gay or bisexual men who had multiple sexual partners in the last two weeks in an area with known virus spread. Shots are also recommended for health care workers at high risk of exposure.

As of this week, Singhal reported about 1,950 local cases. California leads the nation with nearly 4,400 cases.

In July, white men had the highest percentage of cases. But there's now more cases among the Latino and Black populations.

Singhal said Latino residents now account for the largest proportion of monkepox cases in L.A. County.


When accounting for population size, the new data also shows that African American residents have the highest rates of infection at 26 cases per 100,000.

According to the CDC, the Latino and Black populations have disproportionately not received a vaccine against monkeypox.

"The percentages of vaccines administered to Latinos or Hispanic men and non-Hispanic Black men are disproportionately lower than we are seeing represented in cases," said CDC Director Rochelle Walensky.

The White House Monkeypox Response Team says given the success of mobile vaccine clinics at large-scale LGBTQ+ events, the strategy now is to work with local health departments on continued outreach.

White House officials say they will allocate more vaccines to jurisdictions with the most at-risk communities.


Eligibility has been expanded to include pretty much anyone who is at risk of exposure. But despite more availability of vaccines, officials say the big challenge now is to get more people to come back for their second doses.
 

Housecarl

On TB every waking moment
Posted for fair use.....

Riverside County confirms its 1st monkeypox case in child​

by: Cindy Von Quednow
Posted: Sep 16, 2022 / 11:34 AM PDT
Updated: Sep 16, 2022 / 11:34 AM PDT

Riverside County on Friday confirmed its first monkeypox case in a child.

The child is younger than 10 and lives in western Riverside County, officials said. He or she did not require hospitalization and is recovering at home.

Officials were notified of the positive test result this week and are working to determine the source of the infection.

No further details about the infection have been released.

“This case reminds everyone that MPX can impact anyone, regarding of age, gender or sexual orientation,” Dr. Geoffrey Leung, public health officer for Riverside County, said in a news release.

The county has reported about 256 probable or confirmed cases of monkeypox, with the majority coming from the Coachella Valley, officials said.

The virus spreads mostly through direct contact with infectious sores, scabs or boldly fluid during sex and other activities including kissing, hugging, massaging and cuddling.

It can also spread by touching materials used by a person with monkeypox that hasn’t been cleaned, like clothing and bedding.

Additionally, the virus can spread through respiratory secretions during prolonged and close face-to-face contact.

Health officials remind residents of they ways they can protect themselves from monkeypox:

  • Avoiding close contact with people with symptoms like sores or rashes
  • Practicing good hand hygiene
  • Using appropriate personal protective equipment like a mask, gown, and gloves when caring for others with symptoms
  • Avoiding contact with infected materials contaminated with the virus
  • People who become infected should isolate until their symptoms are improving or have gone away completely. A rash should always be well covered until completely healed.
 

Tigerlily

Senior Member
"Given that the risk for monkeypox for health care workers remains very low, we will continue to message on current infection-prevention control recommendations and in particular the use of appropriate PPE," Singhal said.
Health care worker gets monkeypox in spite of ppe, but we are not going to change our health care protocols. That is not very smart now, is it?
 

helen

Panic Sex Lady
Oklahoma suddenly decides to vaccinate health care workers:


  • Healthcare workers providing direct patient care to persons who may be infected with monkeypox
    • Urgent care providers who provide direct patient care
    • Emergency room providers who provide direct patient care
    • Laboratory workers working with monkeypox specimens
    • Healthcare workers diagnosing and/or treating patients with STIs


 

helen

Panic Sex Lady
This isn't over.


A person who studies or works at Arlington Heights High School in Fort Worth has tested positive for monkeypox, the Fort Worth Independent School District said on Friday.

The district did not say whether the person is a student or a district employee or release his or her condition.

As a precaution, sanitizing at the high school began immediately, the district said. Tarrant County Public Health notified the district of the case.



 

helen

Panic Sex Lady
I read somewhere that the PCR test is for general orthopox detection. Confirmation is done with DNA analysis.

This version of monkeypox is different, it's mutated and mutating. Rabbit pox has never been found outside of a lab. Monkeypox was first discovered in a lab in the Netherlands.

For your doomer delight, I offer the following:




Dermatologic Diseases

Laurie Hess DVMDiplomate ABVP, in Ferrets, Rabbits, and Rodents (Second Edition), 2004

Rabbitpox​

Rabbitpox virus, an orthomyxopoxvirus, is a very rare, highly contagious, often fatal infection that is usually seen only among research populations in the United States and The Netherlands.23 This virus is transmitted by ingestion or inhalation of infected tissue.26 Affected rabbits die without clinical signs or develop enlarged lymph nodes, fever, and an erythematous rash that progresses to papules and crusty nodules.

There may be edema of the face, oral cavity, scrotum, and vulva.

3 Some rabbits develop blepharitis, keratitis, and conjunctivitis. Definitive diagnosis is based on characteristic skin lesions and on virus isolation or fluorescent antibody identification of viral antigen in infected tissue. Histopathologic analysis of lesions shows lymphoid necrosis and mononuclear cell infiltration. Treatment is supportive.

 

bw

Fringe Ranger
Variola is smallpox. It had a death rate ranging from 30% to 50%, except in 1901 Indian Territory. That one year it was noted to have a 10% death rate. It was believed to be a milder strain.
Ahh, thanks. Haven't had coffee yet.
 

psychgirl

Has No Life - Lives on TB
Variola is smallpox. It had a death rate ranging from 30% to 50%, except in 1901 Indian Territory. That one year it was noted to have a 10% death rate. It was believed to be a milder strain.
Thank you for explaining…that Twitter discussion I posted, goes on to explain the entire issue.

I should have posted all of it or mentioned it to those who might be interested.
 

helen

Panic Sex Lady
The recommendation stirred controversy on Weibo, with some praising his advice as reasonable and some expressing relief that they didn’t know many foreigners. “It’s good to open the country’s door, but we can’t just let everything in,” one Weibo user wrote.


 

helen

Panic Sex Lady
And then...


In a verified Weibo post on Saturday, Wu suggested: “To prevent possible monkeypox infection, and as part of our daily healthy lifestyle, advise 1) don’t have skin-to-skin contact with foreigners; 2) don’t have skin-to-skin contact with people who have returned from abroad [in the past three weeks].”

He also advised the public not to have skin-to-skin contact with strangers and to use disposable toilet seat covers in public facilities, including in hotels.

Wu’s suggestions were ridiculed by many Chinese internet users, with some saying they found them “racist and discriminatory”.



 

psychgirl

Has No Life - Lives on TB
That’s what happens when years and years of “woke, politically correctness” has been shoved down peoples throats; the whole thing backfires.
Those same governments are accused of being racists the very minute they try to give health and hygiene instructions.

Since when is it racist to be careful when using public toilets or touching strangers when there are infectious diseases going around?
 

Samuel Adams

Has No Life - Lives on TB
Pointing out how to avoid monkeypox is classified as hate speech. It can't be contained.

Any clue as to what the agency title might be of that group that was given power/discretion to split the First Amendment hair for us less enlightened ?
 
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