Blacknarwhal
Let's Go Brandon!
Sounds pretty biggy from here tho.
CORONA Cure found?
- Thread starter Grock
- Start date
Japanese flu drug 'clearly effective' in treating coronavirus, says China
Shares in Fujifilm Toyama Chemical, which developed favipiravir, surged after praise by Chinese official
www.theguardian.com
Zhang Xinmin, an official at China’s science and technology ministry, said favipiravir, developed by a subsidiary of Fujifilm, had produced encouraging outcomes in clinical trials in Wuhan and Shenzhen involving 340 patients.
“It has a high degree of safety and is clearly effective in treatment,” Zhang told reporters on Tuesday.
Patients who were given the medicine in Shenzhen turned negative for the virus after a median of four days after becoming positive, compared with a median of 11 days for those who were not treated with the drug, public broadcaster NHK said.
In addition, X-rays confirmed improvements in lung condition in about 91% of the patients who were treated with favipiravir, compared to 62% or those without the drug.
Coronavirus: the week explained - our expert correspondents put a week’s worth developments in context in one email newsletter
Fujifilm Toyama Chemical, which developed the drug – also known as Avigan – in 2014, has declined to comment on the claims.
Shares in the firm surged on Wednesday following Zhang’s comments, closing the morning up 14.7% at 5,207 yen, having briefly hit their daily limit high of 5,238 yen.
Doctors in Japan are using the same drug in clinical studies on coronavirus patients with mild to moderate symptoms, hoping it will prevent the virus from multiplying in patients.
But a Japanese health ministry source suggested the drug was not as effective in people with more severe symptoms. “We’ve given Avigan to 70 to 80 people, but it doesn’t seem to work that well when the virus has already multiplied,” the source told the Mainichi Shimbun.
The same limitations had been identified in studies involving coronavirus patients using a combination of the HIV antiretrovirals lopinavir and ritonavir, the source added.
In 2016, the Japanese government supplied favipiravir as an emergency aid to counter the Ebola virus outbreak in Guinea.
Favipiravir would need government approval for full-scale use on Covid-19 patients, since it was originally intended to treat flu.
A health official told the Mainichi the drug could be approved as early as May. “But if the results of clinical research are delayed, approval could also be delayed.”
SouthernBreeze
Has No Life - Lives on TB
I can't really answer the questions you have. You would need to ask your doctor. I'm only familiar with Plaquenil, but not if some antibiotics have the same compounds in them.
All I know about the dangers to the eye, my Rheumatologist would not let me start taking Plaquenil, until I made an appt. with an Ophthalmologist to get a baseline on my overall eye health. Once that was established, I started the Plaquenil. Each year, I have to have a complete work up done on my eyes to ensure no damage is being done. After the first year, damage began to show up, so I had to start taking a lower dose every other day. I had another annual testing done in December of last year, and the damage hasn't worsened. From what I understand there is something in the Plaquenil that causes toxicity to the eye itself.
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Unless you are under a drs care dont self medicate. I take plaquenil Every 3 months I go to an eye specialist to make sure it hasn't eaten holes in my retinas. Once a month major blood work usually 5tubes of blood ,twice a year 15 tubes of blood. This is not a drug to play with.
SouthernBreeze
Has No Life - Lives on TB
Exactly. If Plaquenil becomes a treatment for Covid-19, I'm sure it will be used by doctors and specialists under close watch and supervision of the patient.
Kritter
The one and only...
I too am on Plaquenil (Hydroxychloroquine). Generally they don't start worrying about eye problems until you've been on it for five years, although my rheumatologist does require me to get an eye exam yearly before he renews each year. I would highly recommend taking it regardless if it comes to saving your life. (And I have a 90 day supply here if anyone gets sick and desperate, pm me.)
We *really* can't do that! If you read the linked article, it mentions dosages. A different, earlier article mentioned different (lower) doses. You must do your own research (and don't forget to read the side effects and possible drug interactions) on things like this.
This is "extra-label usage", and medical professionals would be risking their licenses to tell you specifics. Sorry, but in this litigious society, it's not safe.
Summerthyme
SouthernBreeze
Has No Life - Lives on TB
Generally speaking, it may be 5 to 7 years, but not always. As I mentioned, I had only been taking it for a year, before damage occurred. My Ophthalmologist has already told me that after 5 years of taking it, I would have to stop it completely. I also had a friend of my family that was taking Plaquenil. She hadn't been taking it long at all. One morning, she woke up to find that one of her eyes had ruptured. Cause....Taking Plaquenil. Everyone is different.
Milkweed Host
Veteran Member
I don't know about elderberry, but love garlic in my veggie juice and take lots of Vitamin C in different forms. L-Ascorbic acid, L-Lysine and L-Proline work together well. I was on a malaria drug for one and a half years until a Dr took me off it, along with a scolding. I didn't notice any side effects. but if it works, great.........
Countrymouse
Country exile in the city
Given my double cornea transplant--and a torn (caught before it detached, thank God) RETINA a few years ago--this sounds like it's contraindicated for me.
It would be just my luck if the "antidote" to this DOES include this drug--so I have to make the choice between my sight and my life...
The article is WRONG, and it is very important to note. The study states 600 mg per day with three 200mg doses.
See the last paragraph of page seven of the study.
Look, this stuff is in Test Phase. Promising Results do not mean it works-for all they know it makes the Virus go into Remission or it moves elsewhere and it might pop back up in the patient in two weeks ten times as bad as before so don't just run out and buy loads of something because you see it mentioned.
Also, you nee to beabsolutely sure you know what you are taking, it's potential side-effects and Hazards or you will do as much or more damage to yourself than potentially getting the Chinese Virus.
Also, you nee to beabsolutely sure you know what you are taking, it's potential side-effects and Hazards or you will do as much or more damage to yourself than potentially getting the Chinese Virus.
Maybe, maybe not. Had a drug w used in the clnic to treat tape worms 30 years ago. That was it's only use. Found out about 12 years ago it works on Sarcoptic Mange. Sarc Mange was a laborous multiple Bath and Dip in my day with concerns of contracting it yourself.
Neither Tapes nor Mange have any resemblance to each other, the bionomes they live in are totally different but the drugs works for both.
Snyper
Veteran Member
One mg is 1000 mcg
Which means the dose in the article is likely a typo.
Earlier reports had them using 200 mgs twice (plus zinc) the first day, then 100 mgs 2x daily for 5 days with apparent success.
Summerthyme
It is right in the study. It isn't hidden. 200 mg, three times per day for ten days. When the the treatment added the azithromycin it was very effective.
Read the study, or don't. Research the drugs, or don't. Believe it, or don't.
Here is the short section regarding the azithromycin regarding the dosing from:
Gautret et al. (2020) Hydroxychloroquine and azithromycin as a treatment of
COVID‐19: results of an open‐label non‐randomized clinical trial. International Journal of
Antimicrobial Agents – In Press 17 March 2020 – DOI : 10.1016/j.ijantimicag.2020.105949
Demographics and clinical presentation
Among hydroxychloroquine-treated
patients six patients received azithromycin (500mg on day1 followed by 250mg per day, the
next four days) to prevent bacterial super-infection under daily electrocardiogram control.
And, here is the result:
When comparing the effect of hydroxychloroquine treatment as a single drug and the effect of
hydroxychloroquine and azithromyc in combination, the proportion of patients that had negative PCR results in nasopharyngeal samples was significantly different between the two
groups at days 3-4-5 and 6 post-inclusion (Table 3). At day6 post-inclusion, 100% of patients
treated with hydroxychloroquine and azithromycin combination were virologicaly cured comparing with 57.1% in patients treated with hydroxychloroquine only, and 12.5% in the control group (p<0.001). These results are summarized in Figures 1 and 2. Drug effect was significantly higher in patients with symptoms of URTI and LRTI, as compared to asymptomatic patients with p<0.05 (data not show).
Read the study, or don't. Research the drugs, or don't. Believe it, or don't.
Here is the short section regarding the azithromycin regarding the dosing from:
Gautret et al. (2020) Hydroxychloroquine and azithromycin as a treatment of
COVID‐19: results of an open‐label non‐randomized clinical trial. International Journal of
Antimicrobial Agents – In Press 17 March 2020 – DOI : 10.1016/j.ijantimicag.2020.105949
Demographics and clinical presentation
Among hydroxychloroquine-treated
patients six patients received azithromycin (500mg on day1 followed by 250mg per day, the
next four days) to prevent bacterial super-infection under daily electrocardiogram control.
And, here is the result:
When comparing the effect of hydroxychloroquine treatment as a single drug and the effect of
hydroxychloroquine and azithromyc in combination, the proportion of patients that had negative PCR results in nasopharyngeal samples was significantly different between the two
groups at days 3-4-5 and 6 post-inclusion (Table 3). At day6 post-inclusion, 100% of patients
treated with hydroxychloroquine and azithromycin combination were virologicaly cured comparing with 57.1% in patients treated with hydroxychloroquine only, and 12.5% in the control group (p<0.001). These results are summarized in Figures 1 and 2. Drug effect was significantly higher in patients with symptoms of URTI and LRTI, as compared to asymptomatic patients with p<0.05 (data not show).
Yeah, you're right. Better to die the first time around.
Research it or don't, because right now you're talking out of your posterior orifice.
intowolves
Veteran Member
There are physicians in high infection risk arenas who have
already started personally taking Plaquenil prophylactically.
Panic Early, Beat the Rush!
- Shane
www.timebomb2000.com
already started personally taking Plaquenil prophylactically.
Panic Early, Beat the Rush!
- Shane
PREP - KI4U ReadiMasks in-stock for same-day shipping...
View: https://www.youtube.com/watch?v=MnhgyQZEseQ View: https://www.youtube.com/watch?v=m2uWWKPd7fQ More videos here... https://www.youtube.com/channel/UCDOwYDMH-B2Vf3kGycnGWKg Specs & Test results here...
Docs (and Vets) can prescribe off-label. They do it all the time.
NOTE: I SAID DOCTORS AND VETS. FREE-LANCERS SHOULD STICK TO MAINLINING YOUR DIATOMACOUS EARTH.
There would be no problem with PROFESSIONAL use of these against the coronavirus. Proven after decades of use in humans.
My main concern is supply. Malaria is still rampant in many parts of the world, but not generally in parts of the world that have been hit hard with the China bug.
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Yeah, well don't sit on your thumbs too long. The UK is banning export of it and the All Day Chemist website is already out of stock on some of it.
Scenario: You have a moderate case and the doctor would like to prescribe it, but can't, because it's out of stock. You mention that you ordered some and have it.
You finish the story.
Case of mistaken identity. I did not order any...nor would I. Let the pro's handle it.
Sorta like some of the household chemical discussions (ala disasters in the making) that have taken place here in the past week.
Jeezus people....a little knowledge is a dangerous thing.
Just as they are common but powerful chemicals, these are powerful drugs.
No, not mistaken identity at all.
Just a question; how long will it take the pharmaceutical companies to ramp up production?
Good luck!
SouthernBreeze
Has No Life - Lives on TB
I sure hope there isn't a shortage of Plaquenil for those of us who have to take it in order to function!
Hfcomms
EN66iq
Heh..question to be asked is just who makes these two medications? China, India? Both these countries have over a billion of their own people to look out for. Whatever of these meds we have here are going to dry up and only the politicians and high net worth people are going to get first crack at them. We do have some drug manufacturers here and a Trump can order them to drop what they are doing and start cranking out the drugs but it’s going to take a long time to ramp up and hopefully we can source the raw ingredients.
Another way to say that is; where malaria is prevalent, and many are
already taking anti-malarial's, there is less virus taking hold, hmmm...
Panic Early, Beat the Rush!
- Shane
Okay. Six million pills would equal 200,000 courses of treatment (6,000,000 pills / 10 days at three pills per day).
But, it would make a great deal on sense to protect the medical community, right?
Do medical professionals get all of these prophylacticly? If so, what is the prophylactic dosage; is it one pill per day?
straightstreet
Life is better in flip flops
HUGE DEVELOPMENT! ... Now 3 International Studies Find Chloroquine with Azithromycin Shows 100% Success Rate in Treating Coronavirus in 6 Days! (VIDEO) | The Gateway Pundit | by Jim Hoft
HUGE BREAKING NEWS— There are now THREE international studies — China, Australia and France — that found that Chloroquine with Azithromycin Shows 100% Success Rate in Treating Coronavirus in 6 Days!
www.thegatewaypundit.com
Yeah, you're right. Better to die the first time around.
Research it or don't, because right now you're talking out of your posterior orifice.
I did research it and will repeat-don't just run out and load up on it because you saw it on the Internet. Shows promise but can have some serious side effects. Promise doesn't equal a cure and as far as my posterior Orifice you need to take you mind off of it and concentrate on something you can actually do in Reality.
HUGE DEVELOPMENT! ... Now 3 International Studies Find Chloroquine with Azithromycin Shows 100% Success Rate in Treating Coronavirus in 6 Days! (VIDEO) | The Gateway Pundit | by Jim Hoft
HUGE BREAKING NEWS— There are now THREE international studies — China, Australia and France — that found that Chloroquine with Azithromycin Shows 100% Success Rate in Treating Coronavirus in 6 Days!
Sounds better. I likely cannot take it but the rest of you can.
Babs
Veteran Member
I ordered some also. Got an email this morning informing me that it will be 30 days likely before it ships due to the airlines shutting things down.
Babs
Veteran Member
Which one can you not take? Hydroxychloroquine is usually tolerated by people who cannot tolerate Chloroquine.
nOT POSITIVE ABOUT IT BUT THE CHRLOROQUIN CAN CAUSE KIDNEY AND VISION ISSUE. gET VISION ISSUES ALREAY ANF THE TRANSPLANT.
Stupid capslock.
Babs
Veteran Member
The Hydroxychloroquine is much safer with much less side effects, and it just so happens to be the most effective of the two on Coronavirus.
TheSearcher
Are you sure about that?
There are physicians in high infection risk arenas who have
already started personally taking Plaquenil prophylactically.
Panic Early, Beat the Rush!
- Shane
View attachment 187710
PREP - KI4U ReadiMasks in-stock for same-day shipping...
View: https://www.youtube.com/watch?v=MnhgyQZEseQ View: https://www.youtube.com/watch?v=m2uWWKPd7fQ More videos here... https://www.youtube.com/channel/UCDOwYDMH-B2Vf3kGycnGWKg Specs & Test results here...
That seems a dot of significant importance.
Grock
Veteran Member
Teva to Donate Potential COVID-19 Treatment, Hydroxychloroquine Sulfate Tablets to Hospitals Nationwide
Grock
Veteran Member
Bahrain, Belgium report coronavirus treatment touted by Trump is working for patients
Clinical Tests of Hydroxychloroquines to Fight COVID-19 in Bahrain prove successful
By Christine Dolan
Last Updated:
March 26, 2020 - 11:20am
Bahrain and Belgium report their hospitals are successfully treating coronavirus patients with the anti-malaria drug hydroxychloroquine touted by President Trump as a possible breakthrough in the pandemic.
The Kingdom of Bahrain's Supreme Council of Health chairman said his country was among the first to use the drug and that its impact has been "profound," according to the Bahrain News Agency.
Dr. Shaikh Mohamed, who leads the National Taskforce for Combating COVID-19, was also quoted by the news agency as saying hydroxychloroquine was administered according to the same regimens as those used in China and South Korea.
The first COVID-19 case in Bahrain was reported on Feb. 21, and hydroxychloroquine was first administered to patients showing virus symptoms on Feb. 26. As of March 25, the virus had caused 4 deaths in Bahrain, according to the Johns Hopkins Coronavirus Resource Center.
Hydroxychloroquine is used to prevent and treat malaria and is administered to patients with rheumatoid arthritis or lupus.
Meanwhile in Europe, another U.S. ally, Brussels, is reporting similar early successwith the same drug and is taking steps to ensure its availability for the sickest coronavirus patients.
“Using the limited stocks of these medicines for unnecessary or unjustified preventive treatments jeopardizes the availability of these medicines for patients who need them: chronic patients and hospital patients seriously affected by Covid-19,” Belgium's Federal Agency for Medicines and Health Products said this week.
Belgium, like the United States, has begun a longer-term clinical trial on the efficacy of using Hydroxychloroquine to treat COVID-19 patients.
justthenews.com
Clinical Tests of Hydroxychloroquines to Fight COVID-19 in Bahrain prove successful
By Christine Dolan
Last Updated:
March 26, 2020 - 11:20am
Bahrain and Belgium report their hospitals are successfully treating coronavirus patients with the anti-malaria drug hydroxychloroquine touted by President Trump as a possible breakthrough in the pandemic.
The Kingdom of Bahrain's Supreme Council of Health chairman said his country was among the first to use the drug and that its impact has been "profound," according to the Bahrain News Agency.
Dr. Shaikh Mohamed, who leads the National Taskforce for Combating COVID-19, was also quoted by the news agency as saying hydroxychloroquine was administered according to the same regimens as those used in China and South Korea.
The first COVID-19 case in Bahrain was reported on Feb. 21, and hydroxychloroquine was first administered to patients showing virus symptoms on Feb. 26. As of March 25, the virus had caused 4 deaths in Bahrain, according to the Johns Hopkins Coronavirus Resource Center.
Hydroxychloroquine is used to prevent and treat malaria and is administered to patients with rheumatoid arthritis or lupus.
Meanwhile in Europe, another U.S. ally, Brussels, is reporting similar early successwith the same drug and is taking steps to ensure its availability for the sickest coronavirus patients.
“Using the limited stocks of these medicines for unnecessary or unjustified preventive treatments jeopardizes the availability of these medicines for patients who need them: chronic patients and hospital patients seriously affected by Covid-19,” Belgium's Federal Agency for Medicines and Health Products said this week.
Belgium, like the United States, has begun a longer-term clinical trial on the efficacy of using Hydroxychloroquine to treat COVID-19 patients.
Bahrain, Belgium report coronavirus treatment touted by Trump is working for patients
Clinical Tests of Hydroxychloroquines to Fight COVID-19 in Bahrain prove successful
justthenews.com