Posted for fair use and discussion.
http://www.veteranstoday.com/2014/04/21/pandemic-2/
Pandemic
By Chip Tatum
It starts as a rare case of some unknown illness, usually in an obscure area of the world so as not to be immediately recognized by the local medicine man. Then the cases grow and the incidences increase to a noticeable level. Once medical doctors are called in, they find that the disease has spread so quickly among locals that there is an “outbreak” of this disease. Treatment begins, lab tests are completed, however many of the patients are already dying. The incidence of infection from the “outbreak” increases at such a rapid rate, physicians are unable to keep up with the infection. Traditional treatments do not seem to stem the rate of incidence. Soon the outbreak becomes an “epidemic”. Laboratory tests reveal the worst. It is Ebola. If not stopped, the disease, with no cure, can cross borders within days, soon to become a Pandemic.
Ebola hemorrhagic fever (Ebola HF) is one of numerous Viral Hemorrhagic Fevers. It is a severe, often fatal disease in humans and nonhuman primates (such as monkeys, gorillas, and chimpanzees).Ebola HF is caused by infection with a virus of the family Filoviridae, genusEbolavirus. When infection occurs, symptoms usually begin abruptly.
The natural reservoir or carrier host of Ebola viruses, and the manner in which transmission of the virus to humans occurs, remain unknown. This makes risk assessment in endemic areas difficult. With the exception of several laboratory contamination cases (one in England and two in Russia), all cases of human illness or death have occurred in Africa. Until now. There is a suspected case in Canada. A returning businessman from Africa has contracted a disease which mimics the symptoms of Ebola. But this virus is a new strain. Where did it come from? How quickly can it spread? That can be answered quite effectively
Ebola has been modified. Virologist Jens Kuhn at the National Institutes of Health said there may be more varieties out there.. “There might be a lot of variety in these viruses. They might be in many different countries in West Africa, East Africa, or other areas of the world where we have not heard anything of outbreaks so far,” said Kuhn.
Standard treatment for Ebola HF is still limited to supportive therapy. This consists of:
balancing the patient’s fluids and electrolytes
maintaining their oxygen status and blood pressure
treating them for any complicating infections
Timely treatment of Ebola HF is important but challenging since the disease is difficult to diagnose clinically in the early stages of infection. Because early symptoms such as headache and fever are nonspecific to ebola viruses, cases of Ebola HF may be initially misdiagnosed.
Signs and Symptoms
Symptoms of Ebola HF typically include:
Fever
Headache
Joint and muscle aches
Weakness
Diarrhea
Vomiting
Stomach pain
Lack of appetite
Some patients may experience:
A Rash
Red Eyes
Hiccups
Cough
Sore throat
Chest pain
Difficulty breathing
Difficulty swallowing
Bleeding inside and outside of the body
Symptoms may appear anywhere from 2 to 21 days after exposure to Ebola virus though 8-10 days is most common. The problem lies in the fact that during this incubation period, the infected is communicable.
About 10% of those who become sick with Ebola HF are able to recover, while the other 90% do not. The reasons behind this are not yet fully understood. However, it is known that patients who die usually have not developed a significant immune response to the virus at the time of death.
There are several ways in which the virus can be transmitted to others. These include:
direct contact with the blood or secretions of an infected person
exposure to objects (such as needles) that have been contaminated with infected secretions
The viruses that cause Ebola HF are often spread through families and friends because they come in close contact with infectious secretions when caring for ill persons.
During outbreaks of Ebola HF, the disease can spread quickly within health care settings (such as a clinic or hospital). Exposure to Ebola viruses can occur in health care settings where hospital staff are not wearing appropriate protective equipment, such as masks, gowns, and multiple layers of gloves.
Weaponization of Ebola
To date it has not been recorded as bring used as a bio-weapon; however, the bio-weapon programs such as the former Soviet Union’s may have investigated weaponizing Ebola. Three incidents of research scientists becoming infected after being stuck with Ebola-contaminated syringes have been reported: England, 1976 (recovered); USA, February 2004 (recovered); Russia, May 2004 (died).
The variant of Ebola called the Marburg virus has been developed and this strain is more hardy. Work has been done in transferring parts of the Ebola virus into the composition of Smallpox and other diseases. Dr. Ken Alibek, former the First Deputy Director of Biopreparat, speculated that the Russians had aerosolized the Ebola virus for dissemination as a biological weapon. The Japanese terrorist group Aum Shinrikyo reportedly sent members to Zaire during an outbreak to harvest the virus.
Modification of the virus through genetic engineering, or the creation of dispersal methods that could infect people through aerosol methods might also be practical. And the virus itself could conceivably mutate into an airborne disease. In short, given the lethality of Ebola, there is a great incentive to develop methods that would transform this into a viable weapon.
In fact, it would take nearly a week for officials to even respond to this type of pandemic, and by that time, thousands of Americans would be have succumbed to the Ebola virus.
Ebola Hemorrhagic Fever is one of the most virulent viral diseases known to humankind, causing death in up to-90% of all clinically-ill cases. Because of the effectiveness of the mortality rate of the Ebola virus, it is the perfect bio-weapon.
Recent patents recognize the origin of this biological agent. I have linked to the patent filed by Longhorn Vaccines and Diagnostics As you can see, they are referring to Ebola Virus as a biological agent, not a virus. Longhorn employs 2 to 4 employees in their corporate office in Bethesda, Maryland. Hmmmmm
“Until recently, clinical laboratory methods for pathogen detection were labor-intensive, expensive processes that required highly knowledgeable and expert scientists with specific experience. The majority of clinical diagnostic laboratories employed the use of traditional culturing methods that typically require 3 to 7 days for a viral culture–and even longer for some other bacterial targets. Furthermore, traditional culturing requires collection, transport, and laboratory propagation and handling of potentially infectious biological agents such as Ebola, avian influenza, severe acute respiratory syndrome (SARS), etc.”
Do they know something we don’t? Is it possible that this is another case where the government has decided that we can not handle the truth?
A Sudden Outbreak could represent a test of the new weaponized virusebola-rash400
It took only moments to feel the impact of what was happening here. We had just landed in Conakry, the capital of Guinea. In the fields right outside the airport, a young woman was in tears. She started to wail and shout in Susu, one of the 40 languages spoken in this tiny country of 12 million people. The gathered crowd became silent and listened intently. The young man sitting next to me quietly translated, although I already had my suspicions. He told me the woman’s husband had died of Ebola, and then quickly ushered us away. It is probably not surprising the airplane bringing us into Conakry was nearly empty, as are all the hotels here. Not many people in the United States have ever visited Guinea, or could even identify where it sits in West Africa. It is already one of the world’s poorest countries, and the panic around Ebola is only making that worse.
Some of it is justified. That’s because this time, the outbreak is different. In the past, Ebola rarely made it out of the remote forested areas of Africa. Key to that is a grim version of good news/bad news: because Ebola tends to incapacitate its victims and kill them quickly, they rarely have a chance to travel and spread the disease beyond their small villages. Now, however, Ebola is in Conakry, the capital city, with two million residents. Equally concerning: it’s just a short distance from where we touched down, at an international airport.
It has gone “viral,” and now the hope is that it doesn’t go global. But, unfortunately it has already spread across borders into Sierra Leone, Liberia and Mali. West Africa is now at risk.
But the disease is so rare, there’s no incentive for big pharmaceutical companies to develop a treatment. Even so, some small companies, given government incentives, are stepping into that breach. The result: More than half a dozen ideas are being pursued actively. A Reuters report summarizes the new strain
Treatments in Development
Overseen by the US Department of Defense (DoD) under the Transformational Medical Technologies program (TMT) of the Defense Threat Reduction Agency and the National Institutes of Health (NIH) have spent millions of dollars conducting scientific research into the Ebola virus, its potential for being turned into a bio-weapon and certain vaccine efforts through two drug corporations, Massachusetts-based Sarepta Therapeutics and Tekmira Pharmaceuticals of Canada . Then the funding was abruptly cut.
The TMT creates relationships with private sector biotech firms, pharmaceutical corporations and academic institutions, as well as other government agencies to advance biological warfare, research viral and biological weapons and estimate threat levels of all biological agents based on ability to infect and effectiveness of devastation.
The DoD suddenly stopped funding Ebola vaccine research through these two corporations due to financial constraints. With the sporadic nature of Ebola outbreaks, combined with the absolute deadly nature of the virus makes it a hard sell to large pharmaceutical corporations because it “isn’t a huge customer base and big pharma is obviously interested in big profits. So these niche products which are important for biodefense are really driven by small companies,” according to Larry Zeitlin, president of Mapp Biophamracueticals, who is developing therapies to combat Ebola.
Mysteriously, microbiologists and virologists who were involved with research into immunology and bioweapons have either gone missing or found dead over two decades. Some of these scientists had ties to the Howard Hughes Medical Institute, the NIH, the DoD – just to name a few. While the number of experts involved in infectious disease research having died under questionable circumstances has risen exponentially, the US government has remained non-chalant.
News Release March 31, 2014
“>Tekmira Receives Fast Track Designation From FDA for Its Anti-Ebola Viral Therapeutic
VANCOUVER, British Columbia, March 5, 2014 (GLOBE NEWSWIRE) — Tekmira Pharmaceuticals Corporation (Nasdaq:TKMR) (TSX:TKM), a leading developer of RNA interference (RNAi) therapeutics, today announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation for the development of TKM-Ebola, an anti-Ebola viral therapeutic.
Who is Tekmira?
Tekmira Pharmaceuticals Corporation is a biopharmaceutical company in financial trouble. They have been developing a treatment for Ebola, however, funds are low. The company has had several setbacks in their research and development department. Recently their stock has been downgraded. This outbreak offers grant monies from the U.S. and an opportunity to improve their financial position.
NEW YORK (TheStreet) – Tekmira Pharmaceuticals Corporation (Nasdaq:TKMR) has been downgraded by TheStreet Ratings from hold to sell. The company’s weaknesses can be seen in multiple areas, such as its feeble growth in its earnings per share, deteriorating net income, disappointing return on equity and weak operating cash flow.
Why Tekmira?
We must ask ourselves why the government would select a firm as weak, faltering, and as unknown a pharmaceutical company as Tekmira to develop such an important
vaccine. Well let’s look at the facts.
Tekmira has very little on its books in the development stages, therefore it can pay more attention to the development of this vaccine or treatment.
Large Pharmaceuticals are unwilling to take instructions from the FDA or from the Government. Rather they dictate to the government through their congressional employees.
By saving a faltering firm the government can dictate uses, distribution, and manufacturing criteria.
In summary. With Tekmira they have total control.
It has been stated that if a pandemic such as this spreads, (remember the Bird Flu Epidemic), doses could not be prepared in sufficient quantities to treat the world population, The solution is simple and planned. The government will use selective criteria as to who will receive treatments. You see, they are the ones in control, not the pharmaceutical company.
Tekmira stated that it will take time to produce the first round of doses. Interesting enough there will be those who will not qualify for the vaccine. Those who are allergic to eggs will not be able to take the dose.
Vaccine bulk manufacture: For most influenza vaccine production, this is performed in nine to twelve-days old fertilized hen’s eggs. The vaccine virus is injected into thousands of eggs, and the eggs are then incubated for two to three days during which time the virus multiplies. The egg white, which now contains many millions of vaccine viruses, is then harvested, and the virus is separated from the egg white. The partially pure virus is killed with chemicals. The outer proteins of the virus are then purified and the result is several hundred or thousand liters of purified virus protein that is referred to as antigen, the active ingredient in the vaccine. Producing each batch, or lot, of antigen takes approximately two weeks, and a new batch can be started every few days. The size of the batch depends on how many eggs a manufacturer can obtain, inoculate and incubate. Another factor is the yield per egg. When one batch has been produced, the process is repeated as often as needed to generate the required amount of vaccine.
When a Pandemic hits, it is normally downplayed by the government due to National Security issues.Here is a recent example. Remember the H1N1 virus that hit in 2009? It was never reported as a true threat, however the World Health Organization quietly announced this. Of course I was living in South America at the time.
World now at the start of 2009 influenza pandemic
Sorry but I do not recall hearing that there was a pandemic of 30,000 cases of Swine Flu at one point!
That is because the governments fee that the public can not handle the truth. Case and point. Today it has been announced that the government has planned to stop publicly releasing the death toll of the Ebola Epidemic to avoid causing panic. This Epidemic has spread to seven countries in Africa and to Pisa, Italy.
Now back to the current Epidemic of Ebola
CONAKRY , Guinea, April 18 (UPI) — The deadly Ebola virus ravaging Guinea emerged locally, and is a different strain of virus from one discovered in central Africa, virologists confirmed.
The spread of Ebola from Guinea, in western Africa, to neighboring Liberia, has panicked a region with poor health care and porous borders, and has killed 122 people, according to the World Health Organization. Scientists examined the virus genome and learned it is distinct from strains in countries such as Uganda, South Sudan, and democratic Republic of Congo, where Ebola was already known to circulate.
Blood tests from victims determined the disease was not introduced from central Africa.
The Ebola virus that has killed scores of people in West Africa this year is a new strain, and it has quite possibly spread to East Africa and Canada.. “The source of the virus is still not known,” but it was not imported from nearby countries, said Dr. Stephan Gunther of the Bernhard Nocht Institute for Tropical Medicine in Hamburg, Germany.
Virologist Jens Kuhn at the National Institutes of Health said there may be more. “There might be a lot of variety in these viruses. They might be in many different countries in West Africa and East Africa where we have not heard anything of outbreaks so far,” said Kuhn.
The Ebola outbreak is now crossing borders. Formerly only found in the jungle regions, It is now in major cities with International Airports. This Epidemic has now entered East Africa and Europe. The rate of infection and cause is unknown, leaving to question considering the incubation time before symptoms, where it will pop up next. Perhaps in a city near you.
I would be remiss if I did not remind you of the many studies performed concerning the need for population reduction. A pandemic event could trigger such a reduction. Especially when considered a new strain. The question would remain,
Is This A Naturally Occurring Epidemic or A BioWeapon Test.
Visit Chip Tatum’s website
www.chiptatum.com
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