CORONA Main Coronavirus thread

bw

bw

Fringe Ranger
All the different sources and methodologies have roughly bracketed what's going on. The Case Fatality Ratio is somewhere between 11% and 50%, the total deaths in Wuhan are 100,000 minimum, and there are probably between 5M and 7M current infections throughout China. That's what I get out of this.
 
SmithJ

SmithJ

Veteran Member
1911user said:
Gov't unveils new electronic tags for people under Wuhan coronavirus home quarantine | Coconuts Hong Kong

Gov’t unveils new electronic tags for people under Wuhan coronavirus home quarantine
By Coconuts Hong Kong Feb 3, 2020 | 5:27pm Hong Kong time

The government’s chief information officer Victor Lam shows off a new electronic tag that will be given to people under home quarantine as the Wuhan coronavirus fears continue to grip the city. Screengrab via Facebook video/RTHK.
The government’s chief information officer Victor Lam shows off a new electronic tag that will be given to people under home quarantine as the Wuhan coronavirus fears continue to grip the city. Screengrab via Facebook video/RTHK.

The Hong Kong government has announced it has 500 electronic monitoring tags ready to distribute to Hong Kong people placed under home quarantine upon returning to the SAR after having spent time in Hubei province, the epicenter of the ongoing coronavirus outbreak.

The government’s chief information officer, Victor Lam, unveiled the e-tag at a press briefing this afternoon, saying that any Hong Kong residents who have been to Hubei in the past 14 days must undergo home quarantine of 14 days, a measure the new electronic bracelets are meant to ensure.

The tag is paired to a person’s smartphone — using Bluetooth Low Energy, or BLE, technology — and is plugged into the mains at the wearer’s home.

If the person wearing the tag unplugs the phone and leaves the quarantine zone with it, or if the distance between the tag and the phone exceeds 20 meters, an alert will be sent to the Department of Health and the police.

The authorities will also get an alert if the tag is broken or removed. Anyone who violates the home quarantine order faces up to six months in jail and a fine of HK$5,000 (US$644).

Lam added that because of concerns about personal privacy, the e-tag will not collect any personal data, and the tags aren’t equipped with GPS. When asked by reporters how will they be able to find anyone who absconds, Lam said they will first try calling the person on their phone.

At the moment, 500 tags are ready to be handed out, and an additional 1,000 can be made available within two weeks if necessary.

The additional quarantine measures come after the authorities disclosed the city now has 15 confirmed cases of the little-understood and potentially fatal Wuhan coronavirus.

Also at today’s briefing was Undersecretary for Health Chui Tak-yi, who confirmed that the majority of the 97 places at the three current quarantine camps are already occupied, and officials are looking for additional sites. Other proposed sites have met with fierce resistance from nearby residents.

Chui said the government is working on turning the Sai Kung Outdoor Recreation Centre into a quarantine camp, and added that despite a weekend of protests in the area, they’re also moving ahead with plans to turn the Heritage Lodge near Mei Foo Sun Chuen Estate into the city’s fourth quarantine center.

Chui said the location of the lodge as a quarantine center was appropriate given that it’s not close to any apartments — being about a 10-minute walk away from the Mei Foo Sun Chuen Estate and the MTR station — and that the camps were just for people who are under quarantine but asymptomatic.
Click to expand...

So that's what the Apple factories are building!
 
hunybee

hunybee

Veteran Member
www.dailymail.co.uk

'Knight' guards entrance to Chinese village to stop coronavirus spread

The blade-wielding 'knight' bravely faced down motorists coming into the Chinese village, and was reportedly willing to chase down any who tried to force their way through the checkpoint.
www.dailymail.co.uk www.dailymail.co.uk


Horseback 'knight' in armour guards the entrance to Chinese village in bid to stop anyone with coronavirus bringing in the infection
  • Man wielding a long blade is seen facing down a car with his trusty steed
  • Fully clad in gold-coloured armour, he is trying to stop the spread of the virus
  • Tensions towards possible coronavirus hosts are rising in the country
  • Over 24,300 are now confirmed to have been infected


Footage has emerged of a Chinese man on horseback in a full set of armour guarding the entrance to his village amid the Wuhan coronavirus outbreak.
The mystery warrior and inhabitant of an unidentified village reportedly took it upon himself to enforce the Chinese government's lock down measures in order to curb the deadly pneumonia-like virus.
Video circulating on social media shows the devoted villager in a full set of armour position himself and his trusty steed in the middle of the road.


He points at a stopped car with his guandao - a Chinese weapon made from a thick blade attached to a wooden pole - and faces off with the motorist who is reportedly trying to enter his village during the lock down period.
The helmet-wearing village warrior, who is not alone in manning the checkpoint leading in and out of the area, was apparently ready to gallop after the vehicle had the driver tried to force their way through.


The armed villager approaches the car with his large blade, or guandao, to face off with the motorist reportedly trying to enter his village

The armed villager approaches the car with his large blade, or guandao, to face off with the motorist reportedly trying to enter his village

He positions himself in front of the car, blocking the driver's path. He is reportedly doing this to stop anyone who may be infected with the coronavirus from entering his village

He positions himself in front of the car, blocking the driver's path. He is reportedly doing this to stop anyone who may be infected with the coronavirus from entering his village

Disease prevention efforts have been stepped up and tensions towards possible coronavirus hosts are rising as the death toll from the respiratory disease rises to at least 490 in mainland China and 492 worldwide.
More than 24,300 are confirmed to have been infected by the new strain of coronavirus, which is thought to have begun at a so-called 'wet market' in Wuhan, capital of Central China's Hubei Province.
Wuhan Coronavirus: What we know so far
What is this virus?
The virus has been identified as a new type of coronavirus. Coronaviruses are a large family of pathogens, most of which cause mild lung infections such as the common cold.
But coronaviruses can also be deadly. SARS, or severe acute respiratory syndrome, is caused by a coronavirus and killed hundreds of people in China and Hong Kong in the early 2000s.
Can the Wuhan coronavirus kill?
Yes – Over 490 people have so far died after testing positive for the virus.
What are the symptoms?
Some people who catch the Wuhan coronavirus may not have any symptoms at all, or only very mild ones like a sore throat or a headache.
Others may suffer from a fever, cough or trouble breathing.
And a small proportion of patients will go on to develop severe infection which can damage the lungs or cause pneumonia, a life-threatening condition which causes swelling and fluid build-up in the lungs.
How is it detected?
The virus's genetic sequencing was released by scientists in China and countries around the world have used this to create lab tests, which must be carried out to confirm an infection.
Delays to these tests, to test results and to people getting to hospitals in China, mean the number of confirmed cases is expected to be just a fraction of the true scale of the outbreak.
How did it start and spread?
The first cases identified were among people connected to the Huanan Seafood Wholesale Market in Wuhan.
Cases have since been identified around China and are known to have spread from person to person.
What are countries doing to prevent the spread?
Countries in Asia have stepped up airport surveillance. They include Japan, South Korea, Thailand, Hong Kong, Indonesia, Malaysia and Philippines.
Australia and the US are also screening patients for a high temperature, and the UK announced it will screen passengers returning from Wuhan.
Is it similar to anything we've ever seen before?
Experts have compared it to the 2003 outbreak of severe acute respiratory syndrome (SARS). The epidemic started in southern China and killed more than 700 people in mainland China, Hong Kong and elsewhere.
 
R

rondaben

Veteran Member
marsh said:
I have high blood pressure (under treatment.) I was always puzzled by the fact that the Spanish flu took young, healthy people through a "cytokine storm." The 2019 Novel Caronavirus, however, seems to hit older people with hypertension hard and not young people.

I was watching a video on hypertension on the Strong Medicine youtube channel. I came across this slide.

hypertension and cytokine dysregulation.JPG


So hypertension can have something to do with "cytokine disregulation."

Being a dot connector by nature, I looked up cytokine storm
www.quora.com

What is a "cytokine storm," and what are the diseases that cause that?

Answer (1 of 6): 'What is a cytokine storm? What triggers them?' Cytokine storm or Cytokine release syndrome - Wikipedia occurs as a result of overzealous immune responses that generate so much cytokine secretion, hypercytokinesis, that rather than stay local as cytokines normally do, they spill...
www.quora.com www.quora.com
Cytokines are a group of signalling substances the body uses to communicate internally. It is essential for the cells in the immune system to communicate and coordinate immune activity in the defense and repair of damage to the body. Cytokines can be expressed by normal tissue cells to communicate with the immune system, but primarily cytokines are used by the immune system.

At all times, white blood cells circulate in the bloodstream and are the first to sense if a virus or bacteria has infiltrated the body. To fight the pathogens or against infections , white blood cells are accompanied by immune cells. Cytokines signal immune cells such as T-cells and Macrophages to travel to the site of infection. In addition, cytokines activate those cells, stimulating them to produce more cytokines. During this stage, a person's immunity functions properly, and immune cells attack the microbes so they do not get too strong a foothold.

However , for reasons that are not completely understood, too many immune cells can be sent to the infection site. This propagates what is referred to as a cytokine storm or cytokine cascade or hypercytokinemia , where far too many immune cells are caught in an endless loop of calling more and more immune cells to fight the infection. The reaction ends up inflaming the tissue surrounding the infection. Cytokine storms have potential to do significant damage to body tissues and organs.

Symptoms of cytokine storms can be :
  • Hypotension (rapidly falling/low blood pressure)
  • Tachycardia (rapid pulse, more than 100 beats per minute)
  • Dyspnea (difficulty breathing)
  • Fever (temperature higher than 38°C/100°F)
  • Ischemia (restriction of bloodflow, especially to the internal organs)
  • Organ failure (as a result of the lack of oxygen, acidosis and severe failure of the metabolism)
  • Uncontrollable hemorrhage - in relation to influenza, typically of lung and airway tissue.
Cytokine storms can occur in a number of infectious and non-infectious diseases which includes :
  • Graft-versus-host disease (GVHD)

  • Acute Respiratory Distress Summertime (ARDS)
  • Sepsis
  • Ebola
  • Avian Influenza
  • Smallpox
  • Systemic Inflammatory Response Syndrome (SIRS).
Cytokine storm may also be induced by certain medications.

Cytokine storms were held responsible for some widespread diseases such as :

  • The number of healthy young adult deaths during the 1918 Influenza pandemic disease , which killed around 50 to 100 million people.
  • The probable reason for many deaths during the SARS epidemic in 2003.
  • High mortality among healthy young adults in the 2009 swine flu outbreak has led to speculation that cytokine storms could be responsible for these deaths.
______

Then I recalled that HIV drugs have something to do with T cells.
I found this paragraph on an HIV site Starting antiretroviral treatment for HIV

"The CD4 cells (also called T-helper cells) are an important part of the immune system because they fight germs and infections. HIV attacks CD4 cells and reduces the number of them in your body. Without treatment, HIV slowly weakens the immune system, making it harder for your body to fight off illness or infection. "
____________
Anyway, I am no medical professional, but it is getting me closer to understanding why hypertension with the pathology of "cytokine disregulation" might make someone old die of a disease that usually attacks the young and has a symptom of low blood pressure. Perhaps this is also why HIV drugs might work to help regulate the cytokine response.
Click to expand...

Hey Marsh, good work on this. I'll try to clarify it if I can and how Coronovirus plays with all of this.

First, lets talk about the Renin-Angiotensin-Aldosterone system (RAAS). Renin is produced in your kidneys when they feel like they are not getting enough oxygen or blood flow. Renin is an enzyme that will convert another intert substance--angiotensinogen--into Angiotensin 1. As this is circulating throughout the body it will eventually get to the lungs, which produce something called Angiotensin Converting Enzyme (ACE). This converts Angiotensin 1 into Angiotensin 2. There are many blood pressure medications called "ACE inhibitors" (Lisinopril, Ramipril, etc) that inhibit this process. This is important because Angiotensin 2 is a POWERFUL driver of blood pressure. More ACE2 means higher blood pressure essentially. This is accomplished several ways. ACE2 causes the blood vessels to constrict. This causes pressure to go up just like if you place a finger over a garden hose. ACE 2 also causes the release of aldosterone, a hormone with effects on the kidneys. This causes the kidney to hold on to sodium and water. This is a slower process that conserves fluid volume and thus increasing blood pressure. This is another place where we try to address hypertension clinically through the use of diuretics to pull of excess fluids and LOWER volume. Meds that do this can be hydrochlorothiazide, lasix, etc.

CORRECTED (NO, not NO2 and function was reversed. Sorry! it is correct now.)

A final consideration for our discussion is about vascular endothelial dysfuntion. The cells that line the inside of blood vessels are called endothelium. One function of these cells is to produce nitric oxide(NO) that produces a natural relaxation to vessels we can refer to as "vascular tone". Without these cells producing NO you get vasoconstriction and a local increase in blood pressure. If they are destroyed it also causes the vessels to become leaky, much like a soaker hose. One final problem is that if the endothelium is actually destroyed it can cause a blood clot to form. This is a mechanism closeley related in heart disease to heart attacks. I can clarify that later if you are interested.

Now that you have a general idea of how blood pressure works (its more complicated but for our purposes here it is probably sufficient) lets talk about cytokines and what they do.

When white blood cells--those tasked with immune system response--are activated they will begin to signal other parts of the immune system to go into action. It can cause other types of cells to flood into the area to fight infection. They can kill cells that are infected before they go on to release infectious agents (for example a cell may be infected with a virus but has not yet released virus copies. These cytokines can punch a whole in the cell thereby killing it and preventing replication of the virus). As you can imagine these cytokines can have a profound effect on blood pressure. More blood can be shunted into the area of infection so that more white blood cells can participate. The "quarterback" of this response is a T-lymphocyte. It can adhere to infectious agents, vascular endothelium and activate other parts of the system.

So how does all of this work with Coronavirus?

We know that the virus can attach to cells that have ACE2 receptors. This means that cells of the lung, blood vessels, kidneys are targets for the disease. The first stop in infection is the lungs. The virus will infect lung tissue--particularly in the small air sacs called alveoli deep within the lung. The lung tissue has a good amount of white blood cells present to fight infection (as you can imagine, this is one of the primary ways people get infected so your body wants to "forward deploy" its defenses). One thing about alveoli--the walls of these sacs are once cell thick. This is because you want oxygen to diffuse across the cell and into the blood vessel and CO2 across the cell into the alveoli to be exhaled. As the infection progresses across the lung damage begins to occur to these cells. The white blood cells at the site begin to call for reinforcements throgh the use of cytokines. This causes the start of fevers (an effect of cytokines), it causes inflammation in the area, it causes fluid to leak from the blood vessel into the alveoli and gives virus particles a door into the cirulatory system. This reduces the ability of the alveoli to move O2 and CO2 back and forth so the amount of oxygen in the blood begins to drop. You will start to cough to try to expel this fluid in the alveoli.

Now you have two new problems. The virus can attach to ACE2 inhibitors in the blood vessels and kidneys starting another cycle of inflammation. The lower O2 in the blood causes the kidneys to activate the RAAS system we talked about before. This progresses for a few days as more and more cells are infected.

What not is less known in this particular virus is what occurs but I will postulate what I believe happens. White blood cells continue to aggregate to the areas of infection. Infected cells will tend to be stable for a period of time before they essentially self destruct and release thousands or virus particles to continue the infection. I believe this is typically happening 3-6 days after the cell is infected. In the end phase of this disease large swathes of lung tissue is infected. There is a functional pneumonia (all of those alveoli full of fluid). The endothelium is infected and is dysfunctional. The kidneys are being injured and, along with the effect of aldosterone from the activated RAAS, cause fluid retention an the start of kidney failure.

At some point the immune system decides that it has reached a "do or die" situation with regards to the infection. Massive release of cytokines occurs. Coupled with the damage to the body you get the following effects:

Fluid leaks from the blood vessels throughout the body. In the lungs this causes a foamy, high protein (mixed with blood) in the lungs. All of this fluid leaving the circulatory system causes blood pressure to drop (volume loss). The amount of fluid entering the body tissues (including the lungs) is exacerbated because aldosterone has worked to help the body to retain extra fluid. The endothelum is damaged and NO production goes down causing the blood vessels to further dialate and making blood pressure fall even further. The patient has entered ARDS (Acute Respiratory Distress Syndrome) and is in shock (low blood pressure, high heart rate, high respiratory rate, fever, infection). As you can imagine the lung full of high protein fluid is a tissue primed for bacterial infection and secondary co-infection will be common. The patient will need prompt intervention. Antivirals (if they are effective), Antibiotics (to limit co-infection), vasopressors (to cause blood pressure to go up and perfuse all of the organs (brain included). Medications to limit the inflammatory response like steroids will likely be given.

I hope that this has not been to technical but gives an idea of how all of this works. The more you know...
 
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Jubilee on Earth

Jubilee on Earth

Veteran Member
WHO says coronavirus cases surge: 'Most cases in a single day'

https://www.cnbc.com/amp/2020/02/05/who-says-coronavirus-cases-surged-overnight-most-cases-in-a-single-day-since-the-outbreak-started
PUBLISHED WED, FEB 5 2020 11:20 AM EST

KEY POINTS
  • The number of cases for coronavirus surged in the last day, with more than 3,100 new patients confirmed in China, the World Health Organization said.
  • Just 191 of the total cases are outside mainland China, where 80% of those cases are concentrated in Hubei province, the WHO said.
  • Of the cases outside of China, 31 spread through human-to-human contact, mostly from close friends or relatives who had recently been to China.
The number of cases for the flu-like coronavirus surged in the last day, with more than 3,100 new patients confirmed in China, World Health Organization officials said Wednesday.

WHO Director-General Tedros Adhanom Ghebreyesus said at a news conference that the reported cases are "the most cases in a single day since the outbreak started" Dec. 31.

Just 191 of the total cases are outside mainland China, and 80% of those cases are concentrated in Hubei province where the virus was first detected in the city of Wuhan, he said. Of the cases outside of China, 31 spread through human-to-human contact, mostly from close friends or relatives who had recently been to China.

Tedros issued a warning for countries monitoring the outbreak and pleaded for funding: "Invest today or pay more later."

"Our greatest concern is about the potential for spread in other countries with weaker health systems and who lack the capacity to detect and diagnose the virus," he said. "We're only as strong as the weakest link."

"We cannot defeat this outbreak without solidarity. Political solidarity, technical solidarity, and financial solidarity," he continued.

Tedros has been urging the WHO's 196 member countries to "invest in preparedness," not "panic." He said that funding for outbreak preparedness in surrounding countries "has remained grossly inadequate" in the past.

The WHO has tapped $9 million of funding from its contingency fund for emergencies, Tedros said Wednesday. He said the organization has sent medical supplies such as masks, gloves, gowns and diagnostic tests around the world.

He also announced that the WHO is launching a "strategy preparedness and response plan."

The WHO is requesting $675 million to fund the plan for the next three months, he said, adding that $60 million of that would fund WHO operations and the rest for country support.

Infectious disease specialists and scientists say the virus may be more contagious than current data shows. Data on the virus is changing by the day, and some infectious disease specialists say it will take weeks before they can see just how contagious it is.

The respiratory illness is not yet considered a pandemic. A pandemic is "an epidemic occurring worldwide, or over a very wide area, crossing international boundaries and usually affecting a large number of people," according to WHO.
 
Jubilee on Earth

Jubilee on Earth

Veteran Member
US$675 million needed for new coronavirus preparedness and response global plan

Urgent support needed to protect vulnerable countries from outbreak
5 February 2020
Geneva, Switzerland

To fight further spread of the new coronavirus (2019-nCoV) outbreak in China and globally, and protect states with weaker health systems, the international community has launched a US$675 million preparedness and response plan covering the months of February through to April 2020.

“My biggest worry is that there are countries today who do not have the systems in place to detect people who have contracted with the virus, even if it were to emerge,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. “Urgent support is needed to bolster weak health systems to detect, diagnose and care for people with the virus, to prevent further human to human transmission and protect health workers.”

The Strategic Preparedness and Response Plan (SPRP) for the new coronavirus lays out activities and resources needed by international health organizations globally, including WHO, to implement priority public health measures in support of countries to prepare and respond to nCoV-2019 for a period February-April 2020. The objectives of the plan are to limit human-to-human transmission of the virus, particularly in countries most vulnerable if they were to face an outbreak; identify, isolate and care for patients early; communicate critical risk and event information; minimize social and economic impact; reduce virus spread from animal sources; and address crucial unknowns.

The plan focuses on:
  • Rapidly establishing international coordination and operational support;
  • Scaling up country readiness and response operations;
  • Accelerating priority research and innovation.
“The effectiveness of outbreak response depends on the preparedness measures put in place before outbreaks strike,” said Dr Mike Ryan, head of WHO’s Health Emergencies Programme. “That is why we are seeking resources to safeguard the most vulnerable countries to protect people from the new coronavirus before it arrives on the doorstep.”

As noted in the SPRP, WHO assesses that the outbreak poses a very high risk in China, and high risk regionally and globally. The risk assessment was based on factors including the likelihood of further spread, the potential impact on human health, and the varying levels of effectiveness in national preparedness and response measures. Accelerated action, as called for in the plan, can address these risks and areas requiring support.

As of 10 a.m. Central European Time on 5 February, 25 countries have reported confirmed cases of the new coronavirus, including China, where 24,363 people had contracted the virus, or over 99% of all cases. In all other countries, 191 cases have contracted the virus.

US$675 million needed for new coronavirus preparedness and response global plan
 
Tom McDowell

Tom McDowell

BAMN
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Jubilee on Earth

Jubilee on Earth

Veteran Member
Funny (or not so funny), but I've been monitoring Twitter for updates about the virus for the past week now. There has definitely been a huge decline in hashtag posts, and most of it seems to be "approved" content or newswires. I've hardly seen any first hand accounts, videos, photos, or any rumors.

How sad.
 
R

raven

TB Fanatic
Jubilee on Earth said:
Funny (or not so funny), but I've been monitoring Twitter for updates about the virus for the past week now. There has definitely been a huge decline in hashtag posts, and most of it seems to be "approved" content or newswires. I've hardly seen any first hand accounts, videos, photos, or any rumors.

How sad.
Click to expand...
you probably have figured this out by now but it probably should be said out loud.
Quarantine is technically illegal. It is illegal because it is discrimination and we have made discrimination illegal.
And not merely a legal construct, it has become a social construct.
You cannot discriminate against someone with HIV.
You cannot discriminate against someone with coronavirus.

Once you understand this, you will also understand that when a government announces that they will no longer allow persons from Wuhan to enter the country, it is a very big deal.
 
homecanner1

homecanner1

Veteran Member
Hospitals, clinics, pharmacies all need to get a hold of their security situations now. Immediately. They will be targeted for takedowns

This is from Asheville NC St. Joseph hospital, being turned into a shooting gallery for homeless and it is horrifying the implications for spread of disease, either by accident or deliberate malfeasance

video from January 20th-23rd, 2020

https://www.facebook.com/video.php?v=202559710880724
View: https://m.facebook.com/473220790132973/videos/202559710880724/?refsrc=http%3A%2F%2Fwww.godlikeproductions.com%2Fforum1%2Fmessage4257108%2Fpg1&_rdr
 
Tom McDowell

Tom McDowell

BAMN

Interviews On Novel 2019-nCoV Coronavirus In Wuhan

recombinomics.co recombinomics.co

Feb 4

PCR confirmed cases increase to 47,584

National lab confirmations increase - Suspect cases (23,260) below Confirmed (24,324)

Discharged cases (892) doubles deaths (490)

Confirmations on quarantined cruise ship off coast of Japan ex-Hong Kong

Ship has 3711 people with 120 symptomatic and 153 contacts (11 nCov confirmed in first 31 tests)

First sequence from South Korea has orf8 mutation <<<====

orf8 mutations in nCoV and SARS <<<==== Why Dr. Niman follows this sequence in mutations.

CDC sequences two isolates from first nCoV case in United States

orf8 mutation is US sequences from 4 of first 5 cases (WA IL CA AZ)

San Benito cluster cases worsen - transferred to UCSF

Sudden death videos from China including security guard <<<=== Important discussion re MYOCARDITIS.
Sudden Death

Striking similarities with 1918 pandemic

http://mediaarchives.gsradio.net/rense/special/rense_020420_hr3.mp3
===

.
 
Melodi

Melodi

Disaster Cat
Shades of 1348...sadly look for this to become rather common if this pattern is the same as 1918 (one of my great aunts lost her fiance in 1918 and nine months later her sister and her husband adopted a baby...)

parallel_universe liked




曾錚 Jennifer Zeng

@jenniferatntd
·
6h

A 12-year boy went to #Wuhan Civil Affairs Bureau to apply for admission into orphanage. Staff asked situation about him. He showed death certificates of his parents and grandparents: all of them died. Staff members started crying. #coronaviruschina #Coronavirus #武汉肺炎
 
R

raven

TB Fanatic
Melodi said:
Shades of 1348...sadly look for this to become rather common if this pattern is the same as 1918 (one of my great aunts lost her fiance in 1918 and nine months later her sister and her husband adopted a baby...)

parallel_universe liked

曾錚 Jennifer Zeng
@jenniferatntd
·
6h

A 12-year boy went to #Wuhan Civil Affairs Bureau to apply for admission into orphanage. Staff asked situation about him. He showed death certificates of his parents and grandparents: all of them died. Staff members started crying. #coronaviruschina #Coronavirus #武汉肺炎
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It do not cry easily. Breaks my heart
 
Tom McDowell

Tom McDowell

BAMN
Dr Nimans notes on today's CDC presser:
CDC Telebriefing on 2019-nCoV 2/5/20 - 12:15 PM ET


11 confirmed positive cases (no new positives)
testing pending on 76 PUI
diagnostics shipping to 100 labs
enhanced capacity by next week

Four plane loads of Americans arriving (as described in press release)
Some nCoV positives expected
Influenza Pandemic preparation applies to nCoV
800 working at CDC alone on Pandemic response
Looking at supply chains for PPEs

CDC Telebriefing on 2019-nCoV 2/5/20 - 12:15 PM ET

The Centers for Disease Control and Prevention (CDC) will provide an update to media on the 2019 Novel Coronavirus response.
recombinomics.co recombinomics.co
===

.
 
K

KFhunter

Veteran Member
that looks like a Syrian gas attack to me



Tom McDowell said:
Entire apartment dead, DISTURBING.
RT 0:23

===

ETA: From Hal Turner:

halturnerradioshow.com

Virus Completely OUT OF CONTROL, Killing Tens-of-Thousands Every day; Gov't Covering-up

Deaths from the bio-weapon coronavirus outbreak are so widespread, it is mind-boggling. The outbreak in China is completely, totally, out of control...
halturnerradioshow.com halturnerradioshow.com

Videos of Hong Kong at site.

===
.
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O

OldArcher

Has No Life - Lives on TB
Jubilee on Earth said:
Funny (or not so funny), but I've been monitoring Twitter for updates about the virus for the past week now. There has definitely been a huge decline in hashtag posts, and most of it seems to be "approved" content or newswires. I've hardly seen any first hand accounts, videos, photos, or any rumors.

How sad.
Click to expand...

Git used ta it. "Truth" ain't in China, an' it ain't gonna be- 'til somebody'll goes in an' estimates th' corpses... Th' "elites" ain't gonna risk losin' power. 'Course, ain't gonna be no witnessin' what happened. Dead men tell no tales...

OA
 
EMICT

EMICT

Veteran Member
homecanner1 said:
Hospitals, clinics, pharmacies all need to get a hold of their security situations now. Immediately. They will be targeted for takedowns

This is from Asheville NC St. Joseph hospital, being turned into a shooting gallery for homeless and it is horrifying the implications for spread of disease, either by accident or deliberate malfeasance

video from January 20th-23rd, 2020

https://www.facebook.com/video.php?v=202559710880724
View: https://m.facebook.com/473220790132973/videos/202559710880724/?refsrc=http%3A%2F%2Fwww.godlikeproductions.com%2Fforum1%2Fmessage4257108%2Fpg1&_rdr
Click to expand...

That is not the only facility encountering this phenomenon. A homeless person was found in a local hospital's public bathroom dead from an overdose.

Security is way down on the food chain for funding at most hospitals. The main problem, regarding this issue, is that most hospitals are ran by nurses and md's that really have had limited exposure to the 'real world'. Every single person that is treated in a hospital setting is considered a 'patient' whether they are a little old grandma or a serial killer. Once they come through those doors, the expectation is these people are all treated the same as grandma and all relatives (associates) of the patients are welcome as well.

The result is assault on nursing staff, theft of property (one guy actually stole ten TV's from various waiting rooms... was caught on camera... and the administration refused to prosecute or stop him from visiting his relative in the hospital), theft of services (stealing from the cafeteria) etc.

Not only is funding not available for proper security, they are also instructed to take a minimal approach to encounters with highly volatile individuals (criminals). The liberal mindset is in charge of most of these institutions and the result is no better than what we have seen in Boston or elsewhere regarding security and law enforcement.
 
Trivium Pursuit

Trivium Pursuit

Has No Life - Lives on TB
rondaben said:
Hey Marsh, good work on this. I'll try to clarify it if I can and how Coronovirus plays with all of this.

First, lets talk about the Renin-Angiotensin-Aldosterone system (RAAS). Renin is produced in your kidneys when they feel like they are not getting enough oxygen or blood flow. Renin is an enzyme that will convert another intert substance--angiotensinogen--into Angiotensin 1. As this is circulating throughout the body it will eventually get to the lungs, which produce something called Angiotensin Converting Enzyme (ACE). This converts Angiotensin 1 into Angiotensin 2. There are many blood pressure medications called "ACE inhibitors" (Lisinopril, Ramipril, etc) that inhibit this process. This is important because Angiotensin 2 is a POWERFUL driver of blood pressure. More ACE2 means higher blood pressure essentially. This is accomplished several ways. ACE2 causes the blood vessels to constrict. This causes pressure to go up just like if you place a finger over a garden hose. ACE 2 also causes the release of aldosterone, a hormone with effects on the kidneys. This causes the kidney to hold on to sodium and water. This is a slower process that conserves fluid volume and thus increasing blood pressure. This is another place where we try to address hypertension clinically through the use of diuretics to pull of excess fluids and LOWER volume. Meds that do this can be hydrochlorothiazide, lasix, etc.

A final consideration for our discussion is about vascular endothelial dysfuntion. The cells that line the inside of blood vessels are called endothelium. One function of these cells is to produce nitric oxide(NO2) that produces a natural constriction to vessels we can refer to as "vascular tone". Without these cells producing NO2 you get vasodilation and a local drop in blood pressure. If they are destroyed it also causes the vessels to become leaky, much like a soaker hose. One final problem is that if the endothelium is actually destroyed it can cause a blood clot to form. This is a mechanism closeley related in heart disease to heart attacks. I can clarify that later if you are interested.

Now that you have a general idea of how blood pressure works (its more complicated but for our purposes here it is probably sufficient) lets talk about cytokines and what they do.

When white blood cells--those tasked with immune system response--are activated they will begin to signal other parts of the immune system to go into action. It can cause other types of cells to flood into the area to fight infection. They can kill cells that are infected before they go on to release infectious agents (for example a cell may be infected with a virus but has not yet released virus copies. These cytokines can punch a whole in the cell thereby killing it and preventing replication of the virus). As you can imagine these cytokines can have a profound effect on blood pressure. More blood can be shunted into the area of infection so that more white blood cells can participate. The "quarterback" of this response is a T-lymphocyte. It can adhere to infectious agents, vascular endothelium and activate other parts of the system.

So how does all of this work with Coronavirus?

We know that the virus can attach to cells that have ACE2 receptors. This means that cells of the lung, blood vessels, kidneys are targets for the disease. The first stop in infection is the lungs. The virus will infect lung tissue--particularly in the small air sacs called alveoli deep within the lung. The lung tissue has a good amount of white blood cells present to fight infection (as you can imagine, this is one of the primary ways people get infected so your body wants to "forward deploy" its defenses). One thing about alveoli--the walls of these sacs are once cell thick. This is because you want oxygen to diffuse across the cell and into the blood vessel and CO2 across the cell into the alveoli to be exhaled. As the infection progresses across the lung damage begins to occur to these cells. The white blood cells at the site begin to call for reinforcements throgh the use of cytokines. This causes the start of fevers (an effect of cytokines), it causes inflammation in the area, it causes fluid to leak from the blood vessel into the alveoli and gives virus particles a door into the cirulatory system. This reduces the ability of the alveoli to move O2 and CO2 back and forth so the amount of oxygen in the blood begins to drop. You will start to cough to try to expel this fluid in the alveoli.

Now you have two new problems. The virus can attach to ACE2 inhibitors in the blood vessels and kidneys starting another cycle of inflammation. The lower O2 in the blood causes the kidneys to activate the RAAS system we talked about before. This progresses for a few days as more and more cells are infected.

What not is less known in this particular virus is what occurs but I will postulate what I believe happens. White blood cells continue to aggregate to the areas of infection. Infected cells will tend to be stable for a period of time before they essentially self destruct and release thousands or virus particles to continue the infection. I believe this is typically happening 3-6 days after the cell is infected. In the end phase of this disease large swathes of lung tissue is infected. There is a functional pneumonia (all of those alveoli full of fluid). The endothelium is infected and is dysfunctional. The kidneys are being injured and, along with the effect of aldosterone from the activated RAAS, cause fluid retention an the start of kidney failure.

At some point the immune system decides that it has reached a "do or die" situation with regards to the infection. Massive release of cytokines occurs. Coupled with the damage to the body you get the following effects:

Fluid leaks from the blood vessels throughout the body. In the lungs this causes a foamy, high protein (mixed with blood) in the lungs. All of this fluid leaving the circulatory system causes blood pressure to drop (volume loss). The amount of fluid entering the body tissues (including the lungs) is exacerbated because aldosterone has worked to help the body to retain extra fluid. The endothelum is damaged and NO2 production goes down causing the blood vessels to further dialate and making blood pressure fall even further. The patient has entered ARDS (Acute Respiratory Distress Syndrome) and is in shock (low blood pressure, high heart rate, high respiratory rate, fever, infection). As you can imagine the lung full of high protein fluid is a tissue primed for bacterial infection and secondary co-infection will be common. The patient will need prompt intervention. Antivirals (if they are effective), Antibiotics (to limit co-infection), vasopressors (to cause blood pressure to go up and perfuse all of the organs (brain included). Medications to limit the inflammatory response like steroids will likely be given.

I hope that this has not been to technical but gives an idea of how all of this works. The more you know...
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In the later stages you mention here, would inhaled exogenous NO2 reach the blood cells in question to help reduce their dilation?
 
R

rondaben

Veteran Member
Trivium Pursuit said:
In the later stages you mention here, would inhaled exogenous NO2 reach the blood cells in question to help reduce their dilation?
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No, that would not help with it. Best would be vasopressors but that is going to require more intense care than can be given at home. Inhaling NO2 would actually be harmful--these people are going to need a lot of oxygen supplementation for support.

Actually I had an error in that part. I will note and correct.
 
O

OldArcher

Has No Life - Lives on TB
I used ta take my mother to Hopkins, as one of their first geriatric case patients, while they were setting up a new program. Exhaustive tests, good people, good care. Will have ta see how they do with somethin' they're NOT prepared for. Nobody is. Not even, especially, the chinese... Incompetence, incapable, an' corrupt- chinese govmint. Now, having serious thinkin' about the chinese themselves. Third world puts them to shame...

OA
 
Mark D

Mark D

Now running for Emperor.
EMICT said:
Not only is funding not available for proper security, they are also instructed to take a minimal approach to encounters with highly volatile individuals (criminals). The liberal mindset is in charge of most of these institutions and the result is no better than what we have seen in Boston or elsewhere regarding security and law enforcement.
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For an assortment of family reasons, I have had the need to visit the Providence hospital in Everett Washington a few times in the last few years. My experience is that they take building security VERY seriously (access, surveillance, staff, detectors). They also appear to have their act together as far as bio-security goes as well. It is, however, a pretty new facility, and was probably designed with a post-9/11 mindset.
 
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homecanner1

homecanner1

Veteran Member
Our medical profession is rife with LGBT activism and they are truly oblivious to reality at the gritty street level. I also would argue that meth keeps things running in our society now and a certain level of 'unregulated after hours visitation' is probably already going on in the more corrupted bleeding heart liberal enclaves.

Denial. Guilt. "Meth as quick fix to imitate cheap lust" or quietly promote workplace efficiency and they use it in all the danceclubs too. Its a total scourge on our society right now. That was absolutely shocking as a renegade undercover investigation. They best get their priorities straight now, its not about getting Mayor McCheese into the white house or demanding that every hospital floor have a tranny toilet for their public visitors. Its life and death now staring us all down

I cannot imagine the chaos if we lose our nationwide hospital security in this, patients getting raped, drugs stolen by zombie hordes in withdrawl.

Today's Pandemic War Room, Episode 12 with Dr. Steven Hatfill again, this time discussing "plateau' of cases and what to expect. Excellent listening as always. Please share the link far and wide with every state health services crisis response team, sign up for the podcasts and get on Bannon's mailing list

View: https://m.youtube.com/watch?v=jWIKtjAVDRg&feature=youtu.be
 
Trivium Pursuit

Trivium Pursuit

Has No Life - Lives on TB
rondaben said:
No, that would not help with it. Best would be vasopressors but that is going to require more intense care than can be given at home. Inhaling NO2 would actually be harmful--these people are going to need a lot of oxygen supplementation for support.

Actually I had an error in that part. I will note and correct.
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Yes, I was wondering about gas permeability, self-titration for BP, and so forth.
 
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20Gauge

20Gauge

TB Fanatic
Heliobas Disciple said:
Some of the comments under this tweet say 'fake news', so take with a grain of salt.
https://twitter.com/FirstSquawk/status/1224973248036687872
First Squawk@FirstSquawk
3:29 AM · Feb 5, 2020

CHINESE TV: RESEARCH TEAM AT ZHEJIANG UNIVERSITY HAS FOUND AN EFFECTIVE DRUG TO TREAT PEOPLE WITH THE NEW CORONA VIRUS
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Yeah.... anyone who believes this, give me a call or send a text. I have a great deal on a bridge that I want to sell.....and land. The land has great water access....
 
20Gauge

20Gauge

TB Fanatic
GammaRat said:
Here are some personal observations on the "Reported Statistics".

I've been monitoring the virus since the 23rd.

On 1/24 there were:

Confirmed cases: 1287
Recovered cases: 38
Fatal cases: 41

This means there were a little over 1200 active cases at the time.

If you allow those cases 12 days to "run their course", the people who were infected on the 24th have either recovered or died.

Let's look at the statistics release today.

Confirmed cases: 24,363
Recovered cases: 892
Fatal cases: 491

892 + 491 = 1383

1383 "should" account for the majority of the cases that were active on 1/24. There may be a few stragglers that are fighting the virus, but the majority of those infections have run their course.

Of those cases....

35% DIED!

That's much higher than the 3% mortality rate that has been discussed in the past.
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Agreed. This was my point. If someone is in the hospital for months, they don't get counted as part of the recovery or death rates. I am very happy to see it has dropped from the 50% death vs recovery rate..... Hopefully things are getting under control, but with the Chinese I doubt that...
 
Mark D

Mark D

Now running for Emperor.
20Gauge said:
Wouldn't a face shield be better?
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Ideally, you want to keep atmosphere OFF your eyes. A face shield is "better than nothing", but it still allows for virus to land in your eyes, and make it's way into your respiratory system from there.

20Gauge said:
Agreed. This was my point. If someone is in the hospital for months, they don't get counted as part of the recovery or death rates. I am very happy to see it has dropped from the 50% death vs recovery rate..... Hopefully things are getting under control, but with the Chinese I doubt that...
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Having spent more than a little time handling data for corporate/political types: your charts will start to look really good if you stop collecting data that contradicts your narrative.
 
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Tom McDowell

Tom McDowell

BAMN
HHS and CDC Receive Additional Flights Carrying Passengers from China


Media Statement
For Immediate Release: Wednesday, February 5, 2020
Contact: Media Relations
(404) 639-3286

This week, several planes carrying passengers from Wuhan China will arrive in three states. These locations are Travis Air Force Base in Sacramento, CA, Marine Corps Air Station Miramar in San Diego, CA, Lackland Air Force Base in San Antonio, TX, and Eppley Airfield in Omaha, NE.

These planes will be met by a team of CDC personnel deployed there to assess the health of the passengers. The passengers have been screened, monitored and evaluated by medical and public health personnel every step of the way, including before takeoff and during the flight. CDC staff will conduct risk assessments to ensure the health of each traveler, including temperature checks and observing for respiratory symptoms.

These passengers will be issued quarantine orders upon arrival at their designated quarantine location. This legal order is intended to protect the travelers, their families, and the community. This quarantine order will begin on the day the flight left Wuhan and will continue for up to 14 days. Medical care will be readily available at the first onset of symptoms, if needed.

CDC will work with the state and local public health departments to transport any passenger exhibiting symptoms to a hospital for further evaluation.

CDC is committed to protecting the health and safety of Americans. We continue to believe the immediate risk of coronavirus exposure to the general public is low, however, CDC is undertaking these measures to help keep that risk low. CDC is taking these measures to fully assess and care for these passengers to protect them, their loved ones, and their communities.

www.cdc.gov

Coronavirus Disease 2019

CDC provides credible COVID-19 health information to the U.S.
www.cdc.gov www.cdc.gov

===

.
 
20Gauge

20Gauge

TB Fanatic
CaryC said:
According to the report, late on Saturday evening, Tencent, on its webpage titled "Epidemic Situation Tracker", showed confirmed cases of novel coronavirus (2019nCoV) in China as standing at 154,023, 10 times the official figure at the time. It listed the number of suspected cases as 79,808, four times the official figure.
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Of course it is. That is how Chinese math works. I blame it on the problem on the abacus thingy they seem to like using.
 
R

rondaben

Veteran Member
bw said:
Just hauled out my spare oxygen concentrator. Never throw anything away. :)
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Most of the case reports I have read have them starting at 2L O2. I would probably start with the oxygen on these folks at an O2sat of 90-92%. Remember that more is not necessarily always better.
 
20Gauge

20Gauge

TB Fanatic
BenIan said:
Sitting in Federal bankruptcy court right now. A hearing before mine, debtors are having trouble making payments because husbands job (oil industry) has reduced his income due to Coronavirus outbreak. Judge talked for a few minutes about the virus having an adverse effect on oil industry & oil prices. This area of the country is very oil dependent.

Anecdotal I know, but indicative of mass public awareness of the issue and the looming economic effects that are just over the ken.
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It has only been a few weeks and people are already trying to use the virus as a cause of bankruptcy? Wow!!
 
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