[War] How to Recognize Ebola Attack

HeliumAvid

Too Tired to ReTire
http://story.news.yahoo.com/news?tmpl=story&u=/ap/20020507/ap_on_he_me/bioterrorism_guidelines_1

<b>How to Recognize Ebola Attack </b>

Tue May 7, 4:01 PM ET
By LINDSEY TANNER, AP Medical Writer

CHICAGO (AP) - A bioterrorist attack using Ebola (news - web sites) or other so-called bleeding viruses could be especially insidious because the early symptoms seem so ordinary and there is no vaccine or approved drug treatment, experts say in new guidelines for doctors.


The guidelines, published in this week's Journal of the American Medical Association (news - web sites), aim to help doctors recognize biological warfare agents that most have only read about in medical books but that seem more menacing after last fall's anthrax-by-mail attacks.

The recommendations deal with hemorrhagic fever viruses, whose most severe symptom is bleeding, under the skin or from body orifices.

The guidelines note that these viruses already have been turned into weapons by the former Soviet Union and the United States and could cause widespread illness and death.

The guidelines were created by the Working Group on Civilian Biodefense, which is composed of doctors and public health experts from the military, civilian government agencies and universities.

This is the sixth set of bioterrorism guidelines from the group, which previously published recommendations in JAMA for handling anthrax, smallpox and plague.

"Most of our health professionals are unfamiliar with these viruses and would be hard-pressed to provide a quick diagnosis," said Sen. Bill Frist, R-Tenn., a physician who has pushed for bioterrorism preparedness.

Still, health care workers should know a bioterrorist attack using these viruses would not be hopeless, said Dr. Luciana Borio of the Johns Hopkins Center for Civilian Biodefense Strategies, where the working group is based.

"We know that mortality can be diminished with good, meticulous medical care," said Borio, lead author of the guidlines. That would include steps to reduce fever and blood pressure, and the use of ventilators and anti-seizure drugs if needed.

But first doctors need to know what they are dealing with. Victims of Ebola and other hemorrhagic viruses, such as Marburg, Yellow fever and Rift Valley fever, can show early, flu-like symptoms within two to 21 days that can include fevers, facial redness, lethargy and headaches.

The more serious, telltale symptoms such as bleeding may take longer to develop. But there is no routine diagnostic test. Blood samples would have to be sent to one of only two federal laboratories nationwide that can test for the viruses.

Suspected victims would need to be hospitalized and isolated from other patients. Because of the highly contagious body secretions, health care workers would need heavy face masks or shields and goggles, double gloves and impermeable hospital gowns.

Ribavirin, a drug approved by the Food and Drug Administration (news - web sites) for another ailment, is useful in only some types of hemorrhagic viruses and it is not widely available, according to the guidelines.

Dr. Neal Shipley, head of the emergency department at North General Hospital in New York City, said the guidelines are useful for doctors like him who would be on the front line in such an attack, but the advice needs to be accompanied by federal money for training and equipment.

"It's one thing to have the masks and suits sitting in someone's office. It's another thing to have personnel on every shift, 24-7, who know how to use them," Shipley said. As for the possibility of a bioterrorist attack, "we're really crossing our fingers that it doesn't happen."
 

HeliumAvid

Too Tired to ReTire
http://story.news.yahoo.com/news?tmpl=story&u=/nm/20020507/hl_nm/bioweapons_virus_1

<b>Hemorrhagic Viruses Could Be Bioweapons: Report </b>

Tue May 7, 5:40 PM ET

NEW YORK (Reuters Health) - Experts warn in a report released Tuesday that the US is ill-prepared in the event of a biological attack with a group of viruses known as hemorrhagic fever viruses (HFVs), which include the dreaded Ebola (news - web sites).


A group of 26 representatives from The Working Group on Civilian Biodefense presents its recommendations in the May 8th issue of the Journal of the American Medical Association (news - web sites). The panel is made up of experts from academic medical centers, public health groups, military services, government agencies and other emergency management institutions.

In all, there are four families of HFVs, according to the report. They cause eight diseases thought to pose serious risk if used as biological weapons: Ebola, Marburg, Lassa, New World arenavirus, Rift Valley fever, yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease.

Like anthrax, the US government has classified HFVs as "category A bioweapon agents."

"An outbreak of Ebola and Marburg would have a significant impact on our society, because they carry significant morbidity and mortality, and other than supportive medical care, there are no specific treatments," said lead author Dr. Luciana Borio of Johns Hopkins University in Baltimore, Maryland, in a prepared statement.

In the report, Borio and colleagues point out that "hemorrhagic fever viruses have been weaponized by the former Soviet Union, Russia and the United States. There are reports that yellow fever may have been weaponized by North Korea (news - web sites)." What's more, the "former Soviet Union and Russia produced large quantities of Marburg, Ebola, Lassa, and New World arenaviruses...until 1992."

Before the US biological weapons program was halted in 1969, American researchers developed yellow fever and Rift Valley fever viruses as weapons, according to the report.

Currently, the drug ribavirin is the only potentially effective medication available for HFVs. However, it is not effective against all of the viruses and is not widely available, according to the report. And the authors warn that diagnosis of any given HFV could be delayed given that most physicians are unfamiliar with these diseases. Most of the time, the infections begin with fever and rash.

The group is calling for a broad range of efforts to increase research into new treatments, rapid diagnosis of HFVs and methods to safely handle potentially infected people and biological samples

"It is not possible to predict whether any of the hemorrhagic fever viruses are likely to be used as a bioweapon," added Borio. "However, we know that it is not impossible to weaponize these viruses and we, in medicine and public health, are obliged to prepare."

SOURCE: Journal of the American Medical Association 2002;287:2391-2405.
 
Top