MNKYPOX Monkeypox - Consolidated Thread.

G

ghost

Veteran Member
Tigerlily said:
Rare case of monkeypox confirmed in England, UK Health Security Agency says
The patient, who is believed to have contracted the infection on a trip to Nigeria, is being treated at an specialist unit in London. Though monkeypox can be spread through close contact, there is a very low risk of transmission to the public.

Skynews Saturday 7 May 2022 17:08, UK
Pic: WHO/Nigeria Centre for Disease Control

Image: Monkeypox is mainly spread by wild animals. Pic: WHO/Nigeria Centre for Disease Control

A rare case of monkeypox has been confirmed in England, health officials have said.
The viral infection usually causes mild illness and most people recover within a few weeks and is similar to human smallpox.

Initial symptoms include fever, headache, muscle aches, backache and exhaustion.
However, severe illness can occur in some individuals.
The patient found with monkeypox recently travelled to the UK from Nigeria, where they are believed to have contracted the infection.

The person is receiving care at the expert infectious disease unit at the Guy's and St Thomas' NHS Foundation Trust in London.
According to the NHS, monkeypox is mainly spread by wild animals in parts of west or central Africa and the risk of catching it in the UK is very low.

More at Rare case of monkeypox confirmed in England, UK Health Security Agency says
Click to expand...
OK, here is one, for the so called experts.
What happens when you combine all of the worlds infections into one ?
OK, experts answer me this question, sense all you so called expects, KNOW IT ALL ????
 
jward

jward

passin' thru
Today, 12:16 AM

Documents Show Wuhan Lab Recently Assembled Monkeypox Strains Creating Contagious Pathogens

May 23, 2022

The Wuhan Institute of Virology admitted that its premises lacked basic laboratory safety measures while undertaking comparable research on strains of killer bat coronaviruses that could potentially infect individuals. Now, explosive documents show that the Wuhan lab recently assembled monkeypox strains creating contagious pathogens.

The Wuhan Institute of Virology built a monkeypox virus genome, enabling the virus to be detected by PCR tests, employing a technology that scientists have warned could result in the creation of a “contagious pathogen.”

The paper (read below) was first published in February 2022, just months before the most recent international outbreak of monkeypox cases, which has now spread to the United States.

The report, written by nine Wuhan Institute of Virology experts and published in the lab’s quarterly scientific journal Virologica Sinica, also follows the widespread usage of Polymerase Chain Reaction (PCR) tests to detect COVID-19-positive patients.

In the study “Efficient Assembly of a Large Fragment of Monkeypox Virus Genome as a qPCR Template Using Dual-Selection Based Transformation-Associated Recombination,” scientists seemed to recognize a part of the monkeypox virus genome, allowing PCR testing to detect the virus. ...

Documents Show Wuhan Lab Recently Assembled Monkeypox Strains Creating Contagious Pathogens - GreatGameIndia[/B][/B]
 
jward

jward

passin' thru
(Study referred to in above video, post #61, Pathfinder, NIH, Wuhan were working on monkeypox)

Efficient assembly of a large fragment of monkeypox virus genome as a qPCR template using dual-selection based transformation-associated recombination - KeAi

Virologica Sinica

Available online 28 February 2022

Redirecting

doi.org

LeiYangabLingqianTianabLeshanLiabQiuhongLiuabXiangGuoabYuanZhouaRongjuanPeiaXinwenChenaYunWanga

Highlights

•The first TAR assembly system using dual-selection markers.
•Highly efficient TAR assembly system with a zero rate of vector recircularization.
•Assembly of an MPXV genomic fragment containing multiple qPCR detection targets.

Abstract

Transformation-associated recombination (TAR) has been widely used to assemble large DNA constructs. One of the significant obstacles hindering assembly efficiency is the presence of error-prone DNA repair pathways in yeast, which results in vector backbone recircularization or illegitimate recombination products. To increase TAR assembly efficiency, we prepared a dual-selective TAR vector, pGFCS, by adding a PADH1-URA3 cassette to a previously described yeast-bacteria shuttle vector, pGF, harboring a PHIS3–HIS3 cassette as a positive selection marker. This new cassette works as a negative selection marker to ensure that yeast harboring a recircularized vector cannot propagate in the presence of 5-fluoroorotic acid. To prevent pGFCS bearing ura3 from recombining with endogenous ura3-52 in the yeast genome, a highly transformable Saccharomyces cerevisiaestrain, VL6-48B, was prepared by chromosomal substitution of ura3-52with a transgene conferring resistance to blasticidin. A 55-kb genomic fragment of monkeypox virus encompassing primary detection targets for quantitative PCR was assembled by TAR using pGFCS in VL6-48B. The pGFCS-mediated TAR assembly showed a zero rate of vector recircularization and an average correct assembly yield of 79% indicating that the dual-selection strategy provides an efficient approach to optimizing TAR assembly.

!
 
jward

jward

passin' thru
Tonix stock crashed after monkeypox outbreak. (Who would want a pox-vectored Covid vaccine now?) The horsepox virus was brought back to life in Canada for only $100,000. (Money was officially from Tonix - but who financed them?) I think the Canadian lab is the same one the US NIH is working with to do the universal coronavirus vaccine research now.

The earliest monkeypox symptom onsets reported were in Canada and England. The early case in Canada has no international travel history reported.

At Tonix, we have developed horsepox as the viral vector, which is the “sheep” in this analogy, and we have engineered it to express the spike protein from SARS-CoV-2 as the antigen, which is the “wolf’s clothing”. The foundational work on this vector can be traced back to the 18th Century and the creation of the very first vaccine that led to the eradication of smallpox.

But we are working on a very modern version called horsepox. It wasn’t possible to make our vaccine until synthetic biology emerged as a new field. A few years ago, making our vaccine was at the forefront of synthetic biology. We think that horsepox is still the largest virus ever synthesized. We believe horsepox is the most advanced form of a series of pox viral vectors, and that horsepox has capabilities beyond those of the canarypox vector that was used in the HIV vaccine Thai trial.

Discussion - Thoughts on a global outbreak of monkeypox - FluTrackers News and Information

Discussion - Thoughts on a global outbreak of monkeypox
flutrackers.com
 
bw

bw

Fringe Ranger
ghost said:
OK, here is one, for the so called experts.
What happens when you combine all of the worlds infections into one ?
OK, experts answer me this question, sense all you so called expects, KNOW IT ALL ????
Click to expand...

There's no assertion in play that says all infections are being combined.

Whassamatta, you feeling let down by science?
 
Tristan

Tristan

Has No Life - Lives on TB
jward said:
Today, 12:16 AM

Documents Show Wuhan Lab Recently Assembled Monkeypox Strains Creating Contagious Pathogens

May 23, 2022

The Wuhan Institute of Virology admitted that its premises lacked basic laboratory safety measures while undertaking comparable research on strains of killer bat coronaviruses that could potentially infect individuals. Now, explosive documents show that the Wuhan lab recently assembled monkeypox strains creating contagious pathogens.

The Wuhan Institute of Virology built a monkeypox virus genome, enabling the virus to be detected by PCR tests, employing a technology that scientists have warned could result in the creation of a “contagious pathogen.”

The paper (read below) was first published in February 2022, just months before the most recent international outbreak of monkeypox cases, which has now spread to the United States.

The report, written by nine Wuhan Institute of Virology experts and published in the lab’s quarterly scientific journal Virologica Sinica, also follows the widespread usage of Polymerase Chain Reaction (PCR) tests to detect COVID-19-positive patients.

In the study “Efficient Assembly of a Large Fragment of Monkeypox Virus Genome as a qPCR Template Using Dual-Selection Based Transformation-Associated Recombination,” scientists seemed to recognize a part of the monkeypox virus genome, allowing PCR testing to detect the virus. ...

Documents Show Wuhan Lab Recently Assembled Monkeypox Strains Creating Contagious Pathogens - GreatGameIndia[/B][/B]
Click to expand...


Well, that's just shocking.

What's that saying?

Once is Happenstance...
 
Tristan

Tristan

Has No Life - Lives on TB
jward said:
Tonix stock crashed after monkeypox outbreak. (Who would want a pox-vectored Covid vaccine now?) The horsepox virus was brought back to life in Canada for only $100,000. (Money was officially from Tonix - but who financed them?) I think the Canadian lab is the same one the US NIH is working with to do the universal coronavirus vaccine research now.

The earliest monkeypox symptom onsets reported were in Canada and England. The early case in Canada has no international travel history reported.

At Tonix, we have developed horsepox as the viral vector, which is the “sheep” in this analogy, and we have engineered it to express the spike protein from SARS-CoV-2 as the antigen, which is the “wolf’s clothing”. The foundational work on this vector can be traced back to the 18th Century and the creation of the very first vaccine that led to the eradication of smallpox.

But we are working on a very modern version called horsepox. It wasn’t possible to make our vaccine until synthetic biology emerged as a new field. A few years ago, making our vaccine was at the forefront of synthetic biology. We think that horsepox is still the largest virus ever synthesized. We believe horsepox is the most advanced form of a series of pox viral vectors, and that horsepox has capabilities beyond those of the canarypox vector that was used in the HIV vaccine Thai trial.

Discussion - Thoughts on a global outbreak of monkeypox - FluTrackers News and Information

Discussion - Thoughts on a global outbreak of monkeypox
flutrackers.com
Click to expand...


Just what this World needs: Synthetic Virii!

I'm sure nothing but Good could ever come of that!
 
K

ktrapper

Veteran Member
Tristan

Tristan

Has No Life - Lives on TB
This may have been posted before, but in case:

Dr. John Campbell's update on Monkeypox, and the NIH and Wuhan being involved in 'Studying' it...

View: https://www.youtube.com/watch?v=4E6cD-VWhQY

rt: 22:09

Very interesting...


They are raising alarms that there's enough transmission that wildlife in Outbreak countries could pick up the virus, and therefore become endemic in those countries.

(Perfect reason to get a New, Amazing Vaccine out there, eh?)
 
Last edited:
Tristan

Tristan

Has No Life - Lives on TB
helen said:
May 26 - 25 cases confirmed


https://twitter.com/i/web/status/1529819527172739073
View: https://twitter.com/MeetJess/status/1529819527172739073
s=20

June 1 - 52 cases confirmed

montreal.ctvnews.ca

Quebec health ministry confirms 52 cases of monkeypox

The number of monkeypox cases in Quebec has more than doubled since last week, according to figures released Wednesday.
montreal.ctvnews.ca montreal.ctvnews.ca
Click to expand...


Any word whether transmission is still suspected to be mainly in the MSWM community?

Or, has it begun community transmission?

(I'm trying to catch up...)


eta:
It would also be pretty interesting to see the numbers of Vacc'd / unVacc'd.
 
Last edited:
H

Housecarl

On TB every waking moment
jward said:
WHO Says LGBTQ+ Parades Should Go Ahead Despite Monkeypox Outbreak

Brendan Byrne
May 31, 2022 10:42 am

monkeypox-990x557.jpg
Image: Illustration




There is no reason to avoid LGBTQ+ parades, according to the World Health Organization (WHO), despite the recent outbreak of monkeypox virus, which has been confirmed in over 435 cases in nearly 24 countries and is primarily seen among men who have sex with men.

While the virus is not a sexually transmitted infection, which is typically spread through sperm and vaginal fluids, the most recent outbreak appears to have been spread among men who have sex with other men.
The WHO, on the other hand, emphasized that anyone can contract monkeypox and that it is critical to show support for the LGBTQ+ community.
“It’s important that people who want to go out and celebrate gay pride, LGBTQ pride, to continue to go and plan to do so,” Andy Seale, strategies adviser at WHO’s department of sexually transmitted infections programmes, said at a WHO social media briefing.

“Most of these events – the official events – are outdoors, they’re family friendly. We don’t see any real reason to be concerned about the enhanced likelihood of transmission in those contexts.”
This comes after people expressed concern about upcoming pride marches in New York on June 26 and Berlin on July 23, among other cities.

According to Seale, many of the current cases involve events that occurred in enclosed spaces such as nightclubs.
“Many diseases can be spread through sexual contact. You could get a cough or a cold through sexual contact, but it doesn’t mean that it’s a sexually transmitted disease,” Seale, who advises the WHO on HIV, hepatitis and other sexually transmitted infections, had said earlier.
Monkeypox has never been identified as a sexually transmitted infection, but it can be transmitted through direct contact during sex.
However, transmission occurs primarily “through close contact, such as during sexual activities amongst persons with multiple sexual partners,” according to Dr Andrea Ammon of the European Centre for Disease Prevention and Control (ECDC).

However, Ammon believes that the likelihood of spread in the general population is very low.
Despite being the largest outbreak outside of Africa in 50 years, monkeypox does not easily spread between people, and WHO experts say the threat is not comparable to the coronavirus pandemic.
Officials from the WHO also stated that “This is a manageable situation,” and “the world has a chance to stop this outbreak collectively.” There is a window here “..
insiderpaper.com

WHO Says LGBTQ+ Parades Should Go Ahead Despite Monkeypox Outbreak

There is no reason to avoid LGBTQ+ parades, according to the World Health Organization (WHO), despite the recent outbreak of monkeypox virus, which has
insiderpaper.com insiderpaper.com
Click to expand...

Where have we heard this one before?.....
 
helen

helen

Panic Sex Lady
See posts 652 and 1013.

Legionnaires grows under conditions favorable to monkeypox fomites. Testing is going to get complicated.

News - Gothamist
Two dead, 24 diagnosed in Legionnaires cluster in the Bronx
BY CATALINA GONELLA
PUBLISHED JUNE 1, 2022

Two people have now died from Legionnaires’ disease in the Bronx, health officials said Wednesday.

The city’s health department said 24 people have been diagnosed since May 3rd, and four are currently hospitalized — the latest update on the cluster of cases in the Highbridge neighborhood of the Bronx.
Four cooling towers in the area tested positive for Legionella pneumophila, the bacteria that causes the disease. The health department said the four towers have since been disinfected.

Legionnaires’ disease is a type of pneumonia caused by breathing in vapor containing the bacteria, which grows in warm water. Symptoms include fever, chills, muscle aches and cough. The disease can be treated with antibodies, but can be fatal for those who are considered high risk. It is not contagious.

The two people who died from the current cluster in the Bronx were over the age of 50 and had risk factors for severe disease, health officials said.

New Yorkers living or working in the area experiencing flu-like symptoms are advised to seek evaluation for both COVID-19 and Legionnaires’ disease. Smokers, people with chronic lung disease or compromised immune symptoms are especially at risk.

gothamist.com

Two dead, 24 diagnosed in Legionnaires cluster in the Bronx

Four people are currently hospitalized with the disease.
gothamist.com gothamist.com
 
helen

helen

Panic Sex Lady
82 percent of UK cases did not involve travel.


"The current outbreak is the first time that the virus has been passed from person to person in England where travel links to an endemic country have not been identified," the agency said.

According to the UKHSA, the majority of cases in the United Kingdom — 132 — are in London, while 111 cases are known to be in gay, bisexual, or other men who have sex with men (GBMSM). Only two cases are in women.

Recent foreign travel to a number of different countries in Europe within 21 days of symptom onset has been reported by 34 confirmed cases, or about 18 per cent of the 190 cases of the disease that have been confirmed by the United Kingdom as of May 31.

www.todayonline.com

Health agency confirms community spread of monkeypox in England

LONDON — Monkeypox appears to be spreading from person to person in England, the UK Health Security Agency (UKHSA) said on Wednesday (June 1).
www.todayonline.com www.todayonline.com
 
helen

helen

Panic Sex Lady
helen

helen

Panic Sex Lady
WHO is dealing with the Nigerian clade.

Congo clade is much worse, even without lab enhancements.

There is no logical reason to assume Congo will not rage around the world too.


Health officials in the Democratic Republic of Congo have recorded more than 1,200 cases of Monkeypox and 58 deaths since the beginning of this year.

www.sabcnews.com

DRC records over 1200 cases of monkeypox, with 58 deaths since beginning of 2022 - SABC News - Breaking news, special reports, world, business, sport coverage of all South African current events. Africa's news leader.

Health officials in the Democratic Republic of Congo have recorded more than 1 200 cases of Monkeypox and 58 deaths since the beginning of this year.
www.sabcnews.com www.sabcnews.com
 
helen

helen

Panic Sex Lady
WHO doesn't even know how bad Congo really is. 58 deaths in 1,200 cases is almost one death out of twenty cases. Congo clade is much worse than that.




But across the Democratic Republic of Congo (DRC), where a more virulent strain is endemic, the threat is on another scale. The World Health Organization (WHO) estimates that 1,200 people have been infected with the virus so far this year, including 58 fatalities.

The real figure is probably far higher. Hundreds of deaths are likely going unrecorded, according to Congolese researchers, who say the world ignored the disease for too long and is now paying the price.

www.telegraph.co.uk

Inside the world’s worst monkeypox outbreak

Experts say the DRC’s outbreak, where ‘hundreds have probably been killed’, demonstrates the global threat posed by the illness
www.telegraph.co.uk www.telegraph.co.uk
 
helen

helen

Panic Sex Lady
I told Ancient to buy this stock two years ago, when it was a penny stock.



Tonix Pharmaceuticals Holding Corp. shares jumped 66% to $4.04 after the U.S. Patent and Trademark Office issued a patent for TNX-801 smallpox and monkeypox vaccine and recombinant pox virus platform technology.

www.marketwatch.com

Tonix Pharmaceuticals Shares 66% Higher After Patent for TNX-801

By Chris Wack Tonix Pharmaceuticals Holding Corp. shares jumped 66% to $4.04 after the U.S. Patent and Trademark Office issued a patent for TNX-801 smallpox...
www.marketwatch.com www.marketwatch.com





Tonix Pharmaceuticals Announces Issuance of U.S. Patent for TNX-801 Smallpox and Monkeypox Vaccine and Recombinant Pox Virus (RPV) Platform Technology

June 01, 2022 7:00am

Strengthens Patent Portfolio Protecting Horsepox-Based Live Virus Vaccines
TNX-1840 and TNX-1850 are Potential RPV Vaccines Designed to Protect Against COVID-19
Confirms Leadership Position in Synthetic Biology

Statutory Term of New Patent Expected to Provide Exclusivity Until 2037
​
CHATHAM, N.J., June 01, 2022 (GLOBE NEWSWIRE) -- Tonix Pharmaceuticals Holding Corp. (Nasdaq: TNXP), a clinical-stage biopharmaceutical company, announced today that the United States Patent and Trademark Office (USPTO) issued U.S. Patent No. 11,345,896 to the Company on May 31, 2022. This patent, entitled "Synthetic Chimeric Poxviruses," includes claims covering synthetic horsepox virus, the basis for the Company’s TNX-8011 vaccine in development to protect against monkeypox and smallpox and for the Company’s Recombinant Pox Virus (RPV) platform to protect against other pathogens, including SARS-CoV-2. This patent is expected to provide Tonix with U.S. market exclusivity until 2037, excluding any possible patent term extensions or patent term adjustments.

Tonix Pharmaceuticals Announces Issuance of U.S. Patent for TNX-801 Smallpox and Monkeypox Vaccine and Recombinant Pox Virus (RPV) Platform Technology

ir.tonixpharma.com ir.tonixpharma.com
 
helen

helen

Panic Sex Lady
We just covered bacterial co-environments favorable to monkeypox fomites; how rat infestations can force monkeypox into endemic status; how homeless human encampments can become reservoirs for monkeypox; how Congo clade can become an ugly sister; how testing can get to be a real bitch; and money money money monkeypox.

Your turn. Scare me.
 
pauldingbabe

pauldingbabe

The Great Cat
helen said:
We just covered bacterial co-environments favorable to monkeypox fomites; how rat infestations can force monkeypox into endemic status; how homeless human encampments can become reservoirs for monkeypox; how Congo clade can become an ugly sister; how testing can get to be a real bitch; and money money money monkeypox.

Your turn. Scare me.
Click to expand...



:shkr:

Well... uuhhmmmm....yeah, just.....well
 
kyrsyan

kyrsyan

Has No Life - Lives on TB
helen said:
Uh huh.
:cmpcf:

Cut your number of sexual partners to help fight monkeypox, urges WHO

Cut your number of sexual partners to help fight monkeypox, urges WHO

The illness may not be containable, officials admit as becomes Europe is ‘epicentre of the largest outbreak ever reported’ outside of Africa
Click to expand...
:rofl: :rofl::rofl:In my case that's gonna be kind of hard. I don't think I can go into negative numbers.
Seriously though, I'm kind of glad that life has led us down the path where we haven't really come out of COVID quarantine. I still remember the smallpox outbreaks threats in the early 2000's. I'm just gonna shake my head and work to keep my head above water. Because I don't think any stimulus bills are going to come around to help cover the bills this time if everything shuts down again.
 
psychgirl

psychgirl

Has No Life - Lives on TB
helen said:
This is how it becomes endemic.

Experts have warned “people are scared and they should be” following a huge increase in the UK's rat population.

www.google.com

RATS are lurking in toilet drains in UK homes

A PEST CONTROL expert warned that "no one is safe" as rats are reportedly sneaking up toilet pipes into homes.
www.google.com www.google.com
Click to expand...
That right there is scarier than itchy burning pustules!
If I saw a rat in my toilet :hof: :hof:
 
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