HEALTH Ebola & Melatonin Treatment

2Trish

2Trish

Veteran Member
Found this yesterday, doesn't appear to have been posted yet, if so, please delete or merge.

http://www.ncbi.nlm.nih.gov/pubmed/25262626

J Pineal Res. 2014 Sep 27. doi: 10.1111/jpi.12186. [Epub ahead of print]
Ebola virus disease: Potential use of melatonin as a treatment.
Tan DX1, Reiter RJ, Manchester LC.
Author information
Abstract

The purpose of this report is to emphasize the potential utility for the use of melatonin in the treatment of individuals who are infected with the Ebola virus. The pathological changes associated with an Ebola infection include, most notably, endothelial disruption, dissiminated intravascular coagulation and multiple organ hemorrhage. Melatonin has been shown to target these alterations. Numerous similarities between Ebola virus infection and septic shock have recognized for more than a decade. Moreover, melatonin has been successfully employed for the treatment of sepsis in many experimental and clinical studies. Based on these factors, since the number of treatments currently available is limited and the useable products are not abundant, the use of melatonin for the treatment of Ebola virus infection is encouraged. Additionally, melatonin has a high safety profile, is readily-available and can be orally-self administered; thus, the use of melatonin is compatible with the large scale of this serious outbreak.
 
mzkitty

mzkitty

I give up.
I use melatonin as a sleep aid for the occasional nights I can't just drop off to dreamland. I don't think you can take that stuff in the daytime, much less do things like drive a car or go to work.

Correct me if I'm wrong.


:shkr:
 
MataPam

MataPam

Veteran Member
If you have been exposed to ebola, or worse, are showing any symptoms, I suggest you have no business going shopping or to work, and possibly killing other people. Stay at home and take melatonin.
 
medic38572

medic38572

TB Fanatic
mzkitty said:
I use melatonin as a sleep aid for the occasional nights I can't just drop off to dreamland. I don't think you can take that stuff in the daytime, much less do things like drive a car or go to work.

Correct me if I'm wrong.


:shkr:
Click to expand...

we give it to the son at night 3 mg for his adhd, if we didnt he would never go to sleep. Night Night son
 
M

meandk0610

Veteran Member
I wonder if it helps prophylactically; does it do anything to the virus before you become ill or does it "only" help with the septic/leaky stage.
 
W

Walkin' Away

Senior Member
Morning All,

I just found some info about EVD and melatonin at this online library...
It is interesting and gives good explanations and dosages for possible treatment

Here is the address: onlinelibrary.wiley.com (search for ebola and potential use of melatonin)

Hopefully, we can add this to our arsenal of therapies to help ourselves and those that we care for.

Take Care Everyone... W.A.
 
BertaBurtonLake

BertaBurtonLake

Inactive
Walkin' Away said:
Morning All,

I just found some info about EVD and melatonin at this online library...
It is interesting and gives good explanations and dosages for possible treatment

Here is the address: onlinelibrary.wiley.com (search for ebola and potential use of melatonin)

Hopefully, we can add this to our arsenal of therapies to help ourselves and those that we care for.

Take Care Everyone... W.A.
Click to expand...

There is a rather long and technical PDF here: go to: http://onlinelibrary.wiley.com/ Enter 'ebola melatonin' in the search box and click on the first linked article entitled, "Ebola virus disease: Potential use of melatonin as a treatment". When that comes up, look for and click the link, "get PDF".

I encourage all to read the whole thing, even if it is a little technical in places. Having said that, here are some significant points from the PDF:

*To reduce the worldwide panic and possibly to save lives, it is urgent for medical researchers to propose some alternative remedies which may have positive effects on this epidemic during the intervening period from now to when effective vaccines become available. Based on our extensive knowledge and experience with melatonin and the understanding of the pathology of EVD we strongly believe that melatonin should have some practical utility as a treatment of this rapidly expanding EVD.

* The main causes of death are disruption of vascular endothelium, disseminated intravascular coagulation (DIC), fibrinolysis and followed by multi- organ hemorrhage [3]. The major pathological alterations caused by the Ebola virus are, more or less, associated with the destruction of the endothelial lining of blood vessels. It was reported that the endothelial injury is not the direct result of viral inoculation into the endothelial cells but rather due to a cascade of reactions of immune- and inflammatory responses involving monocytes, macrophages and dendritic cells

* Theoretically, if available treatments had the capacity to stop or reduce this excessive immuno-inflammatory cascade of reactions, it would provide some protection against the disruption of the endothelium and the coagulation abnormality caused by the Ebola virus; therefore, it would likely reduce the death rate.

* The particular and most important reason for melatonin being potentially useful for EVD is that this molecule seems to directly target all the immuno-inflammatory responsive events associated with the Ebola virus infection (Fig. 1). Melatonin is a potent free radical scavenger and an anti-inflammatory agent [8, 9]. It would predictably limit the oxidative stress and inflammatory injury that occurs in the infected endothelial cells and preserve their integrity

* Protecting against endothelial cell injury and preserving vascular structure and function are important to avoid the deadly hemorrhage in late stage EVD.

* It should be pointed out that melatonin is likely not per se an antiviral molecule. Therefore, the use melatonin in EVD is not for the purpose to eradicating the Ebola virus or even curbing its proliferation (although it may have this effect [24]). The strategy for melatonin application is for the purpose of retarding the body’s excessive immuno-inflammatory responses caused by Ebola virus invasion. As a result, the severity of the lethal DIC and hemorrhage, which result from the excessive immuno- inflammatory responses, would potentially be suppressed with the use of melatonin. Therefore, melatonin administration may enhance the resistance of individuals to the Ebola virus infection and provide additional survival time for these patients.

* Key issues related to the use of melatonin probably include early intervention with a large dose (20 mg or more for a single dose; since there is no precedent for an effective melatonin dose, some upward adjustment of the dose may have greater efficacy); this dose should be given several times per day for a prolonged period. The treatment should be initiated as soon as possible after the infection is diagnosed; presumably it would never be too late to begin treatment. Considering the current lack of effective treatments for this devastating disease and with no vaccine available for EVD, the use of melatonin would be worth consideration.
 
Last edited:
rafter

rafter

Since 1999
(20 mg or more for a single dose; since there is no precedent for an effective melatonin dose, some upward adjustment of the dose may have greater efficacy); this dose should be given several times per day for a prolonged period.
Click to expand...

Taking that much you sure wouldn't have any idea what is going on around you.
 
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