9/15/07-9/21/07|Weekly Bird Flu Thread: China finds suspected H5N1 outbreak in ducks

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China finds suspected H5N1 outbreak among ducks

http://www.alertnet.org/thenews/newsdesk/PEK37538.htm

BEIJING, Sept 15 (Reuters) - China has discovered a suspected outbreak of the H5N1 bird flu virus among ducks in an outlying district of the southern metropolis of Guangzhou, the Agriculture Ministry said on Saturday.

The ministry said on its Web site that by Thursday, 9,830 ducks had died of the outbreak in Guangzhou's Panyu District.

Initial tests by provincial officials showed that the birds had died of the highly pathogenic H5N1 virus, which can be transmitted to humans, the ministry said.

They had submitted samples to a national laboratory for further testing, it said, adding that authorities had culled nearly 33,000 ducks to contain the outbreak.

With the world's biggest poultry population and millions of backyard birds roaming free, China is at the centre of the fight against bird flu.

Scientists fear the bird flu virus could mutate into a form that could pass easily from person to person, sparking a global pandemic.

There have been 25 human cases, including 16 deaths, from the virus in China and dozens of outbreaks in birds that have led to the culling of millions of fowl.
 

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'October Mourning,' a novel of the 1918 Spanish flu pandemic


News editor and author James Rada Jr., of Gettysburg, Pa., is familiar with Maryland and local history topics. In fact, he writes a column, "Looking Back,"--for the Cumberland Times-News and spends a lot of time browsing through old newspapers and books for items that catch his attention.

In 2004, he came across some information about the Spanish flu at the same time people were talking about the avian flu.

"As I started--investigating more about the Spanish--flu,--I realized it was an epidemic very few people knew about," Rada said. "It killed about--450 people in Allegany County in October 1918. That's about one percent of the county's population at the time."

Once Rada had the topic, he began compiling a 1918 timeline through the newspapers to get a feel for how the flu had affec-ted--Allegany County and the steps taken to fight it. He also had access to some other local history books and memoirs that added more detail to the events of the time. These provided the author with a framework to build the story, "October Mourning."

In addition, medical research was essential to fully understand the implications of the flu. Some of the information was far too technical for a novel, but he kept those facts in the back of his mind as he wrote "to make sure the flu affected people in a way that actually happened."

"Books--specifically about Spanish flu also allowed me to understand at what level medical research was at that point in time," Rada said.

In the book, the fight against the flu--begins with fictional character Dr. Alan Keener at Western Maryland Hospital in Cumberland.--At the sudden death of a patient, he turns to medical research for answers. The author writes:

"Can I get some tissue samples?" Keener asked.

Keener knew a pathologist on staff who could examine the tissue samples and maybe give him a clue of what happened. Sarah Jenkins might have died of pneumonia, but something created the situation, something had compromised Sarah's natural defenses enough to allow the pneumonia free reign of her body.

"Of what?" (medical examiner) Jack asked.

"Her lungs. I want to see if there's any influenza left in her lungs." Alan paused. "You'd better add some tissue from her feet, as well."

Research makes fiction 'real'

He wasn't going to chance missing anything this time.

In creating 1918 Cumberland, Rada found old photos were a great help to get the visual appearance of the city at the time. He also consulted maps and old personal papers that talked about life in the city. Additionally, he researched general lifestyle issues of that time period to be as authentic as he could.

"Historical fiction, at least for me, involves much more research ... to make sure the historical period or event I'm writing about is an integral part of the story," Rada said. "Writing about historical events also gives me a framework that I have to write my story around. It's kind of like a grapevine growing up a trellis."

Rada's first historical novel, "Canawlers," came after a biking trip along the entire length of the C&O Canal. As he read the biking guide during stops, the author realized that a lot had happened along the canal. Rada started thinking of ways to tell the story. Up until that time, most of his exposure to history had been through history texts in school. He feels "it's not the best way to enjoy it."

"In writing my first historical novel, I noticed that by combining a fictional story with nonfiction events, history became enjoyable," Rada said. Even though people learn something about history when they read one of his novels, he hopes they don't feel like they're being "taught history" as they read.

Rada wants his readers, primarily adults who like historical novels,--to enjoy reading "October Mourning" and to understand how dangerous a flu epidemic can be. According to the author's research, Spanish Flu killed more people than WWI. Forty million people died worldwide. More people died from one year of the Spanish Flu than died in four years of the Black Plague.

--Rada is also grateful to those who have worked with him to get historical information. One is author. Al Feldstein, who has been helpful in discovering where to look for information. Locally, John Kinnaird with the Thurmont Historical Society and Mike Hillman with the Emmitsburg Historical Society have helped with Frederick County history--as well as Mary Mannix of the Maryland Room in the Frederick County Library who has helped him research obscure questions.

Currently, Rada is working on a nonfiction history book set in Frederick County with the technique called "narrative nonfiction." Basically, it's writing nonfiction so that it reads like a novel and involves developing a narrative storyline.

"It combines the big ideas and stories you typically hear about in history books with the little details you rarely hear about, Rada says.
 

JPD

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Scientists set for major disease conference in Chicago

http://afp.google.com/article/ALeqM5gp6cHSBVVQQba1XHLz3L4O0ucTGg

WASHINGTON (AFP) — Thousands of physicians and scientists meet Monday in Chicago to tackle the growing resistance of germs to antibiotics and the effects of global warming on them, at the world's biggest conference on disease-causing microbes.

For the first time at the annual event, "the keynote session is going to be on climate change and the impact on human disease," Jim Sliwa, spokesman for the American Society for Microbiology which is organizing the event, told AFP.

"We know that climate change is going to change the pattern of infectious diseases," he said. "There are so many variables that we don't know what's going to happen."

"As global average temperature increases, we know ... for example, the malaria line in mountainous regions will continue to rise. This is fairly certain because above a certain altitude mosquitoes can't live," he said.

"We know also in the tropics influenza is year-round. There is no influenza season, so as the temperature rises the tropical areas expand and we'll get more year-round influenza."

Presentations at the conference will address the problem of drug-resistant microbes such as tuberculosis, which kills two million people each year.

Pharmaceutical labs will present research on growing challenges such as the resistance of certain staphylococcus bacteria, known as SARM, to antibiotics -- a source of many in-hospital infections, the association said.

They will also discuss the risks of a possible epidemic of a form of bird flu that is dangerous to humans and that could be passed from person to person.

Also on the agenda will be the results of clinical trials on the effectiveness of anti-retroviral therapies on cancers in people carrying HIV, the virus that causes AIDS.

British researchers are to make a presentation on the antibiotic effects of statin drugs, which reduce cholesterol. Research seems to have revealed the mechanism by which chemical action of the liver gives the anti-cholesterol drugs anti-microbe properties.

The association also plans to publish results of a survey on preventive hygiene, which looks at hand-washing habits among Americans. It examined the number of people who wash their hands after using public restrooms.

Other studies have shown that a worldwide campaign launched in 2005 by the World Health Organization to prompt medical personnel to wash and disinfect themselves before touching a patient yielded encouraging results, according to the conference program.

Inadequate hand-washing among doctors and nurses is responsible for millions of infections in hospitals around the world.

Some 12,000 participants including researchers from France, Japan, and Britain will in Chicago for the event, titled the Interscience Conference on Antimicrobial Agents and Chemotherapy. It runs to Thursday.
 

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Surviving the Next Pandemic: Bird Flu and Other Emerging Infectious Diseases

http://www.nyas.org/snc/calendarDetail.asp?eventID=10523&date=9/16/2007 1:00:00 PM

Speaker, Michael Greger, Humane Society of the United States

Diseases leading public health authorities now predict as inevitable a pandemic of influenza, triggered by bird flu and expected to lead to millions of deaths around the globe. The influenza virus has existed for millions of years as an innocuous intestinal virus of wild ducks. What turned a harmless waterborne duck virus into a killer? In an engaging multimedia presentation, Dr. Michael Greger traces the human role in the evolution of this virus. In the face of the coming pandemic, Dr. Greger reveals what we can do to protect our families, and what society can do to reduce the likelihood of such potential catastrophes in the future.

Michael Greger, M.D., is Director of Public Health and Animal Agriculture at The Humane Society of the United States. An internationally recognized lecturer, he has presented at the Conference on World Affairs, the National Institutes of Health, and the Bird Flu Summit, among countless other symposia and institutions, and was invited as an expert witness in defense of Oprah Winfrey at the infamous "meat defamation" trial. Dr. Greger is a graduate of the Cornell University School of Agriculture and the Tufts University.
 

JPD

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China culls 33,000 ducks to contain bird flu outbreak

http://www.news-medical.net/?id=29897

Authorities in China say a suspected outbreak of the H5N1 bird flu virus has been discovered among ducks in an outlying district of the southern city of Guangzhou.

The Agriculture Ministry says as of last Thursday, 9,830 ducks had died of the outbreak in Guangzhou's Panyu District.

Experts say initial test by local officials indicate that the birds had died of the highly pathogenic H5N1 virus and further samples have been sent to a national laboratory for confirmation.

Authorities have reportedly culled almost 33,000 ducks in an attempt to contain the outbreak.

China is at the centre of the fight against bird flu because it has the world's biggest poultry population and millions of backyard birds roam freely.

Since bird flu first re-surfaced in 2003, China has had 25 human cases of which 16 have died and millions of birds have been culled in efforts to eradicate the virus from the country.

This latest outbreak appears to have started on September 5th in a village near Xinzao when ducks started to die; by September 13, 9,830 ducks had been reported dead.

Teams have been sent out to disinfect the affected areas, and no further deaths of birds have been reported in the Panyu district or nearby areas.

China is the world's largest producer of poultry, livestock and aquatic products, and stands to lose considerably if outbreaks of animal diseases are not contained and controlled.

Analysts estimate that animal diseases cost China billions each year and laws recently amended on animal epidemic prevention, now require all animal owners to comply with compulsory vaccination policies, especially owners of poultry and livestock bred in rural backyards, and pets owners in urban houses.

Scientists continue to fear the bird flu virus will mutate into a form that could pass easily from person to person, triggering a global pandemic.
 

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Vaccinated ducks in China died of bird flu

http://www.radioaustralia.net.au/news/stories/s2035353.htm

Last Updated 17/09/2007, 14:42:22
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More than 9,000 ducks that died in a suspected outbreak of bird flu in southern China had been vaccinated against the disease.

China's agriculture ministry says the ducks had died in a village outside the southern city of Guangzhou between September 5th and 13th.

Samples are being tested for the H5N1 bird flu virus and a further 30,000 ducks had been culled by officials since the outbreak.

A director of the Guangdong Animal Epidemic Prevention Centre says the ducks had been vaccinated against the virus.

He added a first vaccination was only 65 percent effective and the birds needed a second to make it 90 percent effective.

Bird flu has so far infected at least 25 people in China, including 16 who later died.

China conducted a huge campaign last year to contain the disease, slaughtering tens of thousands of poultry and stepping up public education efforts.
 

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Mutation fears in bird-flu outbreak

http://www.thestandard.com.hk/news_...=53586&sid=15407483&con_type=1&d_str=20070917

Carol Chung

Monday, September 17, 2007

Nearly 10,000 ducks that died of bird flu at farms near Guangzhou's Panyu district had been vaccinated against the disease, sparking fears the deadly H5N1 virus may have mutated.

According to Guangdong Animal Epidemic Prevention Center director Yu Yedong, the 9,800 ducks that died at Sixian village had been vaccinated. But he added the first vaccination could only be 65 percent effective, while a second shot would have made it 90 percent.

He believed the birds were infected after the first shot. The deaths led to a mass culling of 32,600 ducks on Friday in an attempt to contain the outbreak.

Health workers have been spraying disinfectant on every passing vehicle and duck farms around the village.

Panyu health official Yang Bingyou said all poultry within five kilometers of Sixian village had been registered and quarantined and disinfection measures enforced.

Initial tests on the ducks were positive for a strain similar to the H5N1 virus. Samples were sent to the National Avian Influenza Reference Laboratory for further tests.

The outbreak has triggered fears in Hong Kong that the virus may have mutated. Dr Ho Pak-leung, an infectious diseases expert at Hong Kong University, said there were worries the virus had mutated or the vaccine had not been effective.

Lo Wing-lok, another infectious diseases expert, called for a ban on the import of ducks from areas around Panyu.

Hong Kong Bird Watching Society chairman Cheung Ho-fai said migratory birds from Panyu are likely to carry the virus to the territory, although previous H5N1 cases in Hong Kong had been found to be unrelated to migratory birds.

The Agriculture, Fisheries and Conservation Department said it will monitor the situation and step up inspections at local poultry farms.

Hong Kong New Territories Poultry-Culture (geese and ducks) Mutual Aid Association chairman Kwok Chi-yau said the outbreak has led to a 20 to 30 percent drop in poultry sales.
 

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China confirms bird flu, says food supplies safe

http://www.reuters.com/article/worldNews/idUSWRI81263620070918

By Ben Blanchard

BEIJING (Reuters) - China on Tuesday sought to reassure consumers already spooked by a slew of food scandals that poultry was safe to eat after officials confirmed the first H5N1 bird flu outbreak since May.

The Ministry of Agriculture said on its Web site (www.agri.gov.cn) late on Monday that 36,130 ducks had been culled following the outbreak in Panyu district of the southern metropolis of Guangzhou, not far from Hong Kong.

"All areas which have bird flu outbreaks have to stop trade in live poultry across the board, and shut wet markets," Zhou Bohua, director of the State Administration of Industry and Commerce, told a news conference in Beijing.

His department, along with the Health Ministry and other government bodies, all worked together to cull birds and make sure slaughter houses were regulated, he said.

"For pork, poultry and other sensitive foods which have a close relationship with people, there is supervision carried out at every step of the way to guarantee product quality in the market," Zhou added.

China has been trying to clean up its food and manufacturing sectors following a string of problems with everything from toys to pet food, which has alarmed consumers at home and around the world.

"UNDER CONTROL"

The Agriculture Ministry said the Guangdong bird flu strain was confirmed as a subtype of the H5N1 strain by the National Avian Influenza Reference Laboratory, but that there was no reason to panic.

"At present, the epidemic has been bought under effective control," it said, adding there had been no other reports of outbreaks in the nearby area.

In Hong Kong, the South China Morning Post quoted a Guangzhou official as saying more than 100,000 birds were to be destroyed in the next few days to prevent bird flu from spreading.

"We would rather kill 100,000 ducks wrongfully than miss even one (that has the virus)," Su Zequn, vice mayor of Panyu county's Sixian village, told the newspaper.

It also quoted Yu Yedong, the director of the Guangdong Animal Vaccination Centre, as saying that although almost all poultry in the province had been vaccinated, it took at least 21 days for vaccines to create enough antibodies in birds.

On Monday, Hong Kong suspended chilled and frozen duck and geese imports from Guangdong province following China's announcement that poultry there was suspected to be infected with H5N1.

China's last poultry case of the virus was in May, in the central province of Hunan.

With the world's biggest poultry population and millions of backyard birds roaming free, China is at the centre of the fight against bird flu.

Scientists fear the bird flu virus could mutate into a form that could pass easily from person to person, sparking a global pandemic.

There have been 25 human cases, including 16 deaths, from the virus in China and dozens of outbreaks in birds that have led to the culling of millions of fowl.
 

JPD

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China: Bird flu spreading. Video

http://en.rian.ru/video/20070918/79227529.html

China's southern Guangdong province is the centre of the latest bird flu virus scare. They had submitted samples to a national laboratory for further testing, it said, adding that authorities had culled nearly 33,000 ducks to contain the outbreak. A district official said poultry farms will remain under close surveillance. (46 sec./1.79Mb, shows: 6)
 

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150,000 Poultries Culled in Guangzhou Bird Flu Outbreak

http://www.china.org.cn/english/China/224929.htm

China's southern city of Guangzhou has destroyed 153,320 domestic fowls in the wake of an outbreak of bird flu, local authorities said on Tuesday.

The extermination of 134,384 ducks, 18,786 chickens and 150 doves was carried out in nine villages within a radius of three kilometers from the site of the outbreak, an official with the Panyu district government said.

A total of 68 poultry farmers in Panyu district who have had close contact with ducks killed by bird flu have taken blood tests and medical checkups, and were found to be in good condition.

The Ministry of Agriculture and the National Avian Influenza Reference Laboratory have confirmed a subtype H5N1 bird flu strain killed 9,830 ducks raised in Sixian Village of Panyu District in Guangzhou City since September 5.

The Panyu district government announced on Tuesday the suspension of all poultry markets within a 13-kilometer-radius surveillance zone. Tan Yinghua, Party chief of the district, told Xinhua the district would put more pork, beef and fish on the market to meet the needs of local consumers.

As the world's largest producer of poultry, livestock and aquatic products, China has suffered huge economic losses from outbreaks of animal diseases. It is estimated that animal diseases cost China 40 billion yuan annually

The previous reported case of H5N1 bird flu in China occurred in May in central China's Hunan Province, which killed more than 11,000 poultry with another 52,800 birds being culled.

China has reported 25 human cases of bird flu since 2003, which have resulted in 16 deaths.

(Xinhua News Agency September 19, 2007)
 

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Parts of China not fully ready against bird flu - official

http://orange.advfn.com/news_Parts-of-China-not-fully-ready-against-bird-flu-official_22311528.html

BEIJING (XFN-ASIA) - A senior Chinese agriculture official has warned that
some parts of the country are still unprepared to respond to bird flu, days
after an outbreak in the south, state media reported.

"We are still seeing epidemic outbreaks in certain places, but there are
problems in some areas with unworkable bird flu control measures, vaccinations
not being in place, and untimely monitoring," Vice Agriculture Minister Yin
Chengjie said.

His comments carried in the Beijing News came a day after official media
said the southern city of Guangzhou had culled more than 153,000 ducks and
chickens this week to stamp out an outbreak of the disease.

The cull was ordered after more than 9,000 ducks died from a sub-strain of
the H5N1 virus, which has been known to kill humans.

The cull was carried out in nine villages in the Panyu district near the
city, with 68 poultry farmers undergoing medical precautionary checks, Xinhua
news agency said.

No cases of humans contracting the virus have been reported there, it said.
Yin said China has to strengthen monitoring and response systems nationwide
due to recent outbreaks in "surrounding countries", an apparent reference to
cases of the disease in Vietnam and elsewhere.

"The disease has continued to spread in neighbouring countries. This poses a
big danger to our prevention and control work," he was quoted as saying during a
meeting on Tuesday.
afp
 

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Nigeria: Bird Flu - 1,052 Birds Culled in Nasarawa

http://allafrica.com/stories/200709200338.html

20 September 2007
Posted to the web 20 September 2007

Ahmed Tahir
Lafia

Over 1,052 birds have so far been culled in Panda Development Area of Nasarawa State in the wake of Avian Influenza (Bird Flu) that affected the area just as the people of the area were commended for reporting early signs of the flu.

UNICEF field officer for Avian Influenza, Alhaji Bala Hassan who visited the affected area from their headquarters in Bauchi said the efforts of the people of the area in reporting cases of sick or dead birds as well as their contributions towards the depopulation exercise was commendable.

Bala who was in Nasarawa weekend and visited Kondoro and panda district areas where the incident occurred cautioned the people against taking sick or dead birds for granted and should ensure that poultry meat and eggs are properly cooked before consumption.

He particularly advised parents to keep their children away from sick or dead birds and advised them to always imbibe the culture of washing their hands whenever they come in contact with sick or dead birds to avoid the spread of the flu.

Presenting posters, pamphlets and other educa-tive materials on Avian Influenza to the district head of the area as well as the people, Bala called on them to spread the message among themselves and outside their communities so as to create awareness that would lead to the prevention of the disease.

The UNICEF focal person on Avian Influenza Control in the Ministry of Information, Mallam Abubakar Tanko who also accompanied the UNICEF field officer to the area advised the people to keep away from using poultry droppings as manure follo-wing the dangers associated with the confirmation of HSN1 virus in the area.

The district head of Kondoro, Alhaji Muha-mmeadu Habu who was full of appreciations to UNICEF thanked the officers for their philanthropic gestures in curbing not only the flu but in the area of child survival and other programmes.

He also called on the state government to come to their aid in the payment of compensations due to the birds they have lost.
 

JPD

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Guangzhou Confirms New Bird Flu Outburst; To Cull 10,000 Infected Fowls

http://www.topnews.in/guangzhou-confirms-new-bird-flu-outburst-cull-10-000-infected-fowls-22084

Guangzhou: Chinese experts have confirmed an epidemic of H5N1 avian influenza in domestic fowls in the southern province of Guangzhou. For this reason, Guangzhou has planned to cull another 10,000 domestic fowls against the bird flu outburst.

The Agriculture Ministry and The National Avian Influenza Laboratory have also confirmed the existence of a sub-type of the H5N1 bird flu strain in ducks, which had died since September 5 at poultry farms near to the provincial capital, Guangzhou. In two arenas of Guangzhou’s Panyu district, workers had culled 36,130 ducks in order to prevent the spread of bird flu.

The Panyu district administration declared on Monday that all the 10,000 poultries in the bird flu infected region will be plucked. Mandatory vaccination and medical aids will be followed up in a radius of 5 square kilometers and the entire poultry markets within a 13-meter-radius surveillance zone will be closed down.

The local administration has pledged to recompense poultry farmers for their financial losses and the compensation amount will be decided shortly. Over 50 farmers in the village are taking blood examinations and health checkups.

The local agricultural department will set up a separate headquarter soon to control and prevent bird flu outbreak.

The bureau added that six control teams have been sent off to different areas in Guangzhou, aiding to enforce vaccination on all domestic fowls in the city as of next Tuesday.

As the world’s biggest producer of livestock, poultry and aquatic products, China undergoes much economic losses from outbreaks of animal diseases. It is projected that animal diseases cost China 40 billion yuan every year.

China has reported 25 human infections with the H5N1 strain of bird flu since 2003. Sixteen of those people have died.
 

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Bird flu halts poultry exports

http://www.china.org.cn/english/China/225092.htm

Guangzhou partially suspended exports of live poultry and products such as eggs to neighboring Hong Kong and Macao following the recent outbreak of bird flu, local authorities said yesterday.

The Ministry of Agriculture and the National Avian Influenza Reference Laboratory confirmed on Monday that a subtype H5N1 bird-flu strain had killed 9,830 ducks raised in Sixian Village of Panyu district in Guangzhou earlier this month.

The suspension, which is to last three weeks starting from last Monday, applies to registered poultry farms and plants processing poultry products located within a 24 km radius of the site of the bird-flu outbreak, a spokesman for the Guangdong entry-exit inspection and quarantine bureau said.

Local authorities have also suspended exports of all waterfowl and related products to Hong Kong and Macao for a week, the spokesman said.

Meanwhile, all registered live poultry farms in Guangdong that supply the markets of Hong Kong and Macao have been ordered to make daily reports about their situation, amid efforts to enhance monitoring of bird flu, he said.

Guangzhou had culled 134,384 ducks, 18,786 chickens and 150 doves by Tuesday in nine villages within a 3-km radius of the site of the bird-flu outbreak.

Sixty-eight poultry farmers in Panyu who had close contact with ducks killed by bird flu have taken blood tests and medical checkups, and were found to be in good condition.

The district government announced on Tuesday the suspension of all poultry markets within a 13-km surveillance zone.

The last case of H5N1 bird flu reported in China occurred in May in Central China's Hunan Province. It killed more than 11,000 poultry and led to another 52,800 birds being culled.

(Xinhua News Agency September 20, 2007)
 

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Bird-flu outbreak brought under 'effective control'

http://www.china.org.cn/english/government/225299.htm

Local authorities are keeping a close eye on the bird-flu situation in the Panyu district of this south China city.

"The 68 people who came into close contact with the ducks killed by bird flu are receiving two medical checkups a day and all of them are said to be in good shape," a district government official surnamed Zhong, said.

"The local health authority has initiated its emergency plan to deal with any human cases in the village of Sixian, where the virus broke out, and three other villages nearby," he said.

Anyone with a temperature above 38 C must report immediately to the district disease prevention and control center, Zhong said. And those who were involved in burying the infected ducks must also undergo checkups twice a day.

"The incident is under effective control. I don't think it has affected the local people too much," the official said.

Xiang Qizhao, a duck farmer from Panyu, said: "The price of live ducks has dipped a little bit in the past couple of days, but I'm confident it will soon get back to normal thanks to the local government's immediate and effective measures to deal with the epidemic outbreak."

Officials in Guangzhou said both the supply of poultry - about 480,000 birds per day - and the price were about normal.

Guangzhou is home to about 21.5 million chickens, 7.5 million ducks, 1.4 million geese, 5.6 million pigeons and various other kinds of poultry.

The bird-flu outbreak was reported early this month after more than 9,000 ducks died within days of each other. The National Avian Influenza Reference Laboratory later confirmed the virus was a sub-type of the H5N1 strain.

The local government responded by immunizing all poultry and sterilizing all farms in the district.

(China Daily September 21, 2007)
 
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