8/4/07-8/10/07|Weekly Bird Flu Thread:India New cases of ‘unusual mortality’

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New cases of ‘unusual mortality’

http://www.hindu.com/2007/08/04/stories/2007080462160100.htm

Gargi Parsai

NEW DELHI: Even as 3.31 lakh poultry birds were culled in bird flu-affected Manipur till Friday, two new cases of ‘unusual mortality’ in poultry farms in Tripura and in Mizoram have set off alarm bells. Samples have been sent to the High Security Animal Disease Laboratory in Bhopal to test for the highly pathogenic H5N1.

According to Union Animal Husbandry Joint-Secretary Upma Chawdhry, clinical tests point to normal poultry diseases in Tripura and Mizoram and there was no cause for alarm. The death of 40 birds in Aurangabad also was a “false alarm.” Maharashtra, in any case, is under strict surveillance following an outbreak of bird flu in Jalgaon last year.

Ms. Chawdhry said a flock of 500 poultry birds in a commercial farm of 3,000 died in Khoweii village in West Tripura from IBD (Infectious Bursal Disease) and Cossiodosis.

In another backyard poultry farm in Vambuck village in Mizoram, about eight km from Myanmar, a flock of 120 poultry birds have died, ostensibly from fowl-pox disease. Ms. Chawdhry said restrictions had been imposed in both the villages in the two States.

The Centre has advised the State to ensure “safe disposal and burial” of the dead poultry. “There should be no consumption of poultry in these areas and there should be restriction on movement of poultry.” In Manipur, the culling operation was completed on Friday with the stamping out of 3,31,606 birds and the destruction of 28,103 eggs and 25,242 kg. of feed. A compensation of Rs. 70 lakh had been paid to the affected farmers till Thursday. The compensation is expected to cross Rs. one crore.

Sources said the compensation was not to make up for the commercial cost of the culled birds but to save farmers from deprivation. For three months the farmers cannot rear poultry in the region.

Officially the culling process is over but as the Central Rapid Response Teams go about mopping up and cleaning the area, they might come across unreported poultry, sources said.

The Department said 16 Rapid Response Teams, assisted by 58 labourers and malaria workers of the Health Department were engaged in the task of cleaning and disinfection.
 

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U.S. government orders more of Glaxo's bird flu
vaccine to fill national stockpile

http://wbztv.com/businesswire/APFN-GlaxoSmithKline-/resources_news_html

Friday, August 03, 2007

NEW YORK (AP) British drug maker GlaxoSmithKline said the Department of Health and Human Services placed another order to buy bulk avian flu vaccine to fill the national stockpile in the event of a pandemic.

The company said HHS asked for 22.5 million doses of H5N1 bulk vaccine used to prevent bird flu, under a contract awarded in November 2007. That is on top of the 5 million doses ordered in November 2006.

Glaxo also announced the start of the first pre-pandemic vaccine trials of the company's bird flu vaccine in North America.

In 2005, Glaxo invested about $2 billion in expanding its vaccine manufacturing and development activities in North America, primarily through the acquisition of the Canadian company, ID Biomedical.

U.S. shares of Glaxo fell 74 cents to $51.12 in afternoon trading.
 

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Bird flu human cases stabilise, experts say

http://www.gulf-times.com/site/topi...=164821&version=1&template_id=39&parent_id=21

Published: Saturday, 4 August, 2007, 01:48 AM Doha Time

GENEVA: The bird flu epidemic appears to have stabilised as far as humans go but several developing nations have not been able to stem its spread amongst poultry and domesticated birds, experts said yesterday.

“The number of human cases of bird flu appears to be stable when compared to the same period last year,” Gregory Hartl, World Health Organisation (WHO) spokesman for bird flu told AFP.

The UN health agency reported 56 new human cases of bird flu until July 25 this year, 34 of which were fatal. There were a total of 115 cases last year and 79 deaths.

The WHO has so far recorded 319 cases of bird flu in humans worldwide, 192 of which were fatal.

“In the northern hemisphere, the number of cases in summer has declined marginally from the winter,” Hartl said.

Experts fear the death toll could rise sharply if the virus were to mutate and become easily transmissible between humans.

“Human-to-human transmission are very rare. We think there have been three cases – in Vietnam, Cambodia and Indonesia. And each time the person has had prolonged and direct contact with an affected person,” Hartl said.

WHO head Margaret Chan recently said a fifth of the population in some of the affected countries could contract the potentially fatal H5N1 strain of the bird flu virus.

“From experience we do know that what we call the attack rate of a new pandemic would range – based on past experience it does not necessarily apply for the next pandemic – (to) roughly 20% or thereabout,” Chan had said.
“If there’s a 10mn population, with 20%, 2mn would be affected at different stages. And then the severity of the disease would range from mild to severe,” she added.

Meanwhile, the head of the World Organisation for Animal Health, Bernard Vallat, told AFP that the “presence of the virus is clearly lower among domestic birds this year when compared to the previous year”.

But he warned of a “recrudescence of the virus among wild birds in Europe”, and underlined that four of the 25 countries where avian influenza has been detected have not been “able to control the situation” and that the virus had turned “endemic”.

These four countries were Indonesia, Bangladesh, Egypt and Nigeria, Africa’s most populated nation.

Vallat said the levels of veterinary services were not up to scratch in Indonesia while lack of co-ordination and resources were hampering the fight against bird flu in the other three countries. – AFP
 

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51 people quarantined in Manipur

http://www.thepeninsulaqatar.com/Di...h=August2007&file=World_News2007080482640.xml

Web posted at: 8/4/2007 8:26:40
Source ::: REUTERS

new delhi • India has quarantined 51 people in the remote northeastern state of Manipur following an outbreak of the H5N1 strain of influenza in chickens last month, a senior official said yesterday. “Since all these people had worked in culling or sanitising operations or monitoring people’s health around the affected poultry farm they have to be quarantined and monitored,” said Vineet Chawdhry, joint secretary in the health ministry.

Most had complained of being “unwell”, he added, but did not say whether any had flu-like symptoms. All 51 were on Tamiflu, the popular drug to prevent and treat bird flu, as a precaution, the health ministry said.

Hundreds of cullers were involved in killing nearly 300,000 fowl over the past week in Manipur, a state bordering Myanmar that saw two outbreaks of bird flu in chickens in July alone.

The culling, which took place within a 5km radius around the affected poultry farm near Imphal, capital of Manipur, ended on Thursday. Health officials have completed checks of around 235,000 people in the area, but said they would closely monitor the situation.

Globally, the H5N1 virus has killed at least 192 people out of 319 who have been affected since late 2003, with health experts fearing it could one day mutate into a form that could pass easily between humans, triggering a pandemic.

Authorities also cleared four boys who had been suffering from fever after handling dead or sick poultry in Manipur. But officials in Tripura, another northeast Indian state, were on alert after around 500 chickens died in a commercial poultry farm in a district bordering Bangladesh, where avian flu has spread to a number of areas this year.

Officials said blood and tissue samples had been sent for testing, but added they suspected the deaths to be caused by infectious bursal disease, a viral illness, along with coccidiosis, a parasitic illness found in animals. Western India had two major outbreaks of the H5N1 virus in chickens last year, but has not yet reported any human case.
 

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Localities discuss flu outbreak readiness

http://www.inrich.com/cva/ric/news/...px.-content-articles-RTD-2007-08-04-0108.html

After statewide summit in 2006, health departments have advanced their plans

Saturday, Aug 04, 2007 - 12:08 AM

By TAMMIE SMITH
TIMES-DISPATCH STAFF WRITER

Pandemic flu is no longer front-page news, but the threat is still just as real, officials said yesterday at a Henrico County meeting on preparing for a flu pandemic.

There were just as many questions as answers:

Goochland public-health nurse Susan Scott wanted to know what would happen if people told to stay home during a deadly flu outbreak went to work anyway.

Deneen Herriott, an infection-control nurse at Southside Virginia Training Center in Dinwiddie County, said she is still unsure about the obligations of health-care providers.

"We need legal and ethical input," Herriott said. "The standards of care are going to change. Where does liability stop when you are providing care to others?"

More than 100 people from across the region attended the event at the Sheraton West Hotel on West Broad Street.

"I am not here like Chicken Little to tell you a pandemic is coming," said Dr. Mark Levine, Henrico County health director. "The key question is how do we prepare in the face of uncertainty?"

Although health officials point out it is impossible to predict if or when there will be a flu pandemic, there is particular concern that a bird-flu virus circulating in some parts of Southeast Asia could mutate to a form that is easily passed person-to-person, setting off a worldwide flu outbreak.

Bird-flu viruses like those that have infected poultry farms in Virginia, resulting in millions of poultry being destroyed, "make us really nervous," said veterinarian William Pierson, one of the speakers yesterday. Pierson, an associate professor at the Virginia-Maryland Regional College of Veterinary Medicine at Virginia Tech, said such viruses could mutate and turn virulent.

In the months since a March 2006 statewide summit on pandemic flu preparedness, local health departments have moved forward with preparedness plans.

Different districts are using federal preparedness dollars in different ways.

Richmond officials have hired a pandemic flu coordinator, provided training to first responders and the medical community, and have prestocked locations to be used as medication distribution centers with supplies. In November, Richmond health officials will test procedures for doing mass vaccinations during a mass flu-shot clinic.

The Chesterfield Health District also has hired a pandemic flu coordinator, according to Dr. William Nelson, health district director. The health district has purchased stockpiles of masks, gowns and gloves, installed three portable battery-operated vaccine storage and transport units for use during emergencies, and provided pandemic influenza training to medical staffs at hospitals.

Stephanie B. Flikeid, director of quality assurance at St. Joseph's Villa for Children, attended yesterday's meeting to see how her facility's plan meshes with the overall county plan.

"People are scared," Flikeid said, when they read headlines like "killer flu" that forecast flu pandemic disaster.
 

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More bird flu cases found in Germany

http://news.yahoo.com/s/afp/20070804/hl_afp/healthflugermany

BERLIN (AFP) - More wild birds have been found dead of the H5N1 bird flu virus in Germany, where domestic poultry were infected last month, authorities in Bavaria said Saturday.

Police in the southern state said restrictions on movement had been put in place around the Speichersee lake, east of Munich, after two out of three ducks found dead there were confirmed to have been carrying the virus.

Press reports said around 14 other birds had also been found dead in the area, but it was not known if they were infected with the virus, which is potentially deadly to humans.

More than 150 wild birds have died of H5N1 in southern and eastern Germany in the past few weeks, and a month ago the disease spread to a smallholding in the eastern state of Thueringen.

It was the first time this year that the highly pathogenic strain of avian flu had been found among domestic birds in Germany. Scientists have suggested it could have jumped the border from the neighbouring Czech Republic where it has infected poultry on large turkey and chicken farms.

A number of countries have banned poultry exports from Germany, which battled a widespread bird flu epidemic in 2006. The disease spread to mammals last year, infecting three cats and a marten.
 

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Tripura tightens vigilance along Bangladesh
border following bird flu scare

http://www.dailyindia.com/show/1630...ng-Bangladesh-border-following-bird-flu-scare

Agartala, Aug 5: The Tripura Government has tightened vigilance along its 856-kilometre long border with Bangladesh to stop movement of poultry products in the wake of the death of about 500 chickens in a commercial poultry farm in the state.




The state government has asked the Border Security Force (BSF) to seal the border as a precautionary measure.

"(We have informed) the Inspector General, BSF, to keep vigilance and instruct the personnel posted along the international border, so that no illegal migration or influx of birds (takes place) or poultry products could enter the state," said S.K. Mitra, nodal officer of the state's bird flu and surveillance team.

He added that the customs department and the field officials of the animal resource development department have been asked to keep strict vigilance at important check posts and other areas on any mortality among ducks and poultry birds.

Authorities here have sounded an alert after about 500 chickens were found dead in a commercial poultry farm in Chebri bordering Bangladesh, where avian flu has spread to a number of areas this year.

The birds died in a farm in the Indian Council of Agricultural Research (ICAR) Krishi Vigyan Kendra poultry farm at Chebri in Khowai sub division of West Tripura District.

The state's veterinary officials have started testing birds and feces samples in households and farms across the state to check for the H5N1 strain of the avian flu virus, whose outbreak has also been confirmed in Manipur.

The dead chicken blood and tissue samples have been sent to Bhopal for testing, but officials said they suspected the deaths to be caused by infectious bursal disease, a parasitic illness found in animals.

The deaths were reported in the last three days.

The incident of bird flu has badly affected the poultry market and the prices of chicken have been slashed.

Nikhil Paul, a casual staff of the Krishi Vigyan Kendra poultry farm, who also owns a small poultry, said: "The reports of bird flu in Tripura badly affected the small poultry owners as they donot get even the half price for their stock."

Tripura has around 11,000 small poultry farmers and chicks are mostly imported from Kolkata.

Special dresses have been sanctioned for the poultry workers and disinfectants are spread at suspected areas.

A high level meeting was organised at the State Secretariat on Friday to review the situation. Team of the State Government bird flu surveillance group visited the poultry firm from where the abnormal deaths have been reported.

Manipur had last week sounded an alert after bird flu was confirmed there. Again in Bangladesh, 34 case of outbreak of bird flu has been recorded with the last incident in July last at Denajpur.

Meanwhile, 51 people have been quarantined in Manipur following an outbreak of the H5N1 strain of influenza in chickens last month.

Hundreds of cullers were involved in killing nearly 300,000 fowl over the past week in the state bordering Myanmar that saw two instances of outbreak of bird flu in chickens in July alone.

The Centre has already alerted Mizoram to check illegal smuggling of hens from across Myanmar.

Manipur, Mizoram, Nagaland and Arunachal Pradesh share borders with Myanmar.

The Centre on Friday said that there were no suspected human cases of bird flu and the situation in Chingmeirong village in Manipur, where the outbreak of the bird flu was confirmed on July 25, is now completely under control.

Health teams consisting of 597 health personnel have covered monitoring 44,475 houses with an approximate population of 2.32 lakh.
 

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Lessons From a Bug

http://www.usnews.com/usnews/news/articles/070805/13flu.htm

A pandemic filled beds but offered important insights
By Adam Voiland
Posted 8/5/07

It was just a footnote compared with the more virulent scourge that killed millions more people in 1918, but the 1957 influenza pandemic that sickened some 25 to 30 percent of the American population was a medical watershed for the clues that it offered about how a new strain of influenza could spread.

Americans first got a whiff of the so-called Asian flu when Maurice Hilleman, a physician at Walter Reed Hospital in Washington, D.C., read about an unusually large number of people—some 250,000—who had come down with flu-like symptoms in Hong Kong. Concerned, he immediately requested samples from American servicemen in Asia and within days had his answer. The genetic structure of this strain was like nothing immunologists had ever seen before.

House afire. When the virus finally hit America: "It went like a house on fire," recalls D. A. Henderson, then the chief of the United States Epidemic Intelligence Service. Exacerbated by school openings that fall, the flu spread so rapidly from a few counties in Louisiana that just eight weeks later it had heavily infected more than half the counties in nearly all 50 states.

Although it wasn't particularly potent, the 1957 strain killed about 80,000 Americans. The victims were predominantly the very old and the very young, although the infection occasionally killed otherwise healthy adults as well.

Pharmaceutical companies worked furiously to produce a vaccine, ultimately distributing some 40 million doses. But "they were just a little bit too late," says Arnold Monto, an influenza specialist at the University of Michigan. "They only had significant doses available when the pandemic was peaking." Earlier, scarcities raised questions about who deserved the vaccine first. Official protocol gave priority to military personnel and necessary civic workers, but that didn't stop members of the San Francisco 49ers football team from getting vaccinated before police and firemen.

Despite some manufacturing improvements, experts say the same shortages could occur with a pandemic today. And that concern has caused preparedness officials to plan for community interventions such as school closings and isolation of sick people.

But Henderson says, "It won't work. And you don't need a better example than '57. When you go from just a few scattered outbreaks in the end of August to the whole country infected in eight weeks, at a time when people didn't travel as much as they do today and cities were not as densely populated, what do you think we're going to see today?"

Better, he says, to have good vaccines and to ensure that the medical system can handle the extra load.
 

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Drug trial hopes to beat the bug

http://www.nzherald.co.nz/category/story.cfm?c_id=49&objectid=10455870

5:00AM Sunday August 05, 2007
By Alice Hudson

A new influenza drug being trialled in New Zealand has the potential to save millions of lives during a worldwide pandemic and could be as effective as - or more effective than - Tamiflu in combating a outbreak of avian flu, experts believe.

Antiviral drug Peramivir, developed by US pharmaceutical company BioCryst and sponsored by the US government, is currently being trialled on influenza-infected patients at seven New Zealand "study centres". A single injection of the drug, which like Tamiflu is a neuraminidase inhibitor, stunts the growth of the enzyme neuraminidase needed for the flu virus to flourish in the body.

Greenhithe Medical Centre, in Auckland's northwest, is one of the seven centres seeking flu patients to take part in the trial, which is predicted to run in New Zealand until next month at least.

Trial head at Greenhithe, Dr Nick Gailer, told the Herald on Sunday that the drug trial had massive implications for the treatment of all strains of potentially debilitating influenza, as well as avian flu.

Ultimately, it could see an antiviral injection enter the market which decreased the severity of flu symptoms and the length of time people were sick. If it was proved that it eradicated the disease from the nose more quickly, that would also reduce the amount of time the flu sufferer was contagious.

Gailer said those who had been suffering from flu symptoms for no longer than 48 hours and who were found to definitely have the influenza virus, rather than just a cold were eligible to take part in the trial. One third of patients would be given a placebo, but all patients would receive their initial visit free and would be given paracetamol and lozenges; in return, they would be required to keep a diary of their experience.

Other centres running the trial in New Zealand are in Otara, Dunedin, Hamilton, Rotorua, Taupo and Christchurch.

BioCryst, who was this year awarded a US$100 million ($130 million) contract to develop the drug by the US government, is testing Peramivir in Australia, South Africa and the Northern Hemisphere.

Virologist Dr Lance Jennings told the Herald on Sunday it was always helpful to have more than one anti-viral medication to combat a virus, as the bugs can become resistant to medications over time. Peramivir's chemical structure is substantially different from those of Relenza and Tamiflu. A US study in 2001 also found the drug was more potent than others against a range of avian influenza strains.

A separate hospital-based trial of the drug is also running, involving three New Zealand hospitals.

Gailer said it was too early to put a cost on the drug. Tamiflu, which is taken orally over five days, costs about $80 for the course.

How does it work?
The enzyme neuraminidase is responsible for the release of particles from 'flu-infected cells. These particles then spread the disease and may also assist in spreading the virus through mucus, allowing it to escape the host through a sneeze or a cough, and infect others. It is believed that Peramivir can stop the spread of the disease - an important advance in the management of influenza. Peramivir may also be effective in preventing 'flu, regardless of the particular strain or mutation.

Flu stats

The dreaded flu has been keeping a relatively low profile so far this season, statistics show. But experts say they can never predict when a big outbreak will occur, and there is often a nasty, late-season spike of infections in August and September. There have been four strains of the virus lurking around this year - two A and two B strains, virologist and National Influenza Strategy Group (NISG) spokesman Dr Lance Jennings, said. Weekly reports of GP consultations from 80 surgeries showed levels of 'flu to be "normal" so far this season, he said.
 

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Little poultry feed left after bird flu scare

http://www.worldpoultry.net/news/id2205-25915/little_poultry_feed_left_after_bird_flu_scare.html

// 06 Aug 2007

Farmers outside the 5km danger zone of the bird flu-hit Chingmeirong farm, Manipur, India, are facing the prospect of losing healthy birds to starvation.

This is due to the ban on the movement of poultry feed and the closure of poultry markets.

Following the outbreak of avian influenza, the inflow of poultry products and poultry feed from Siliguri via Assam and Nagaland has been suspended. This, in turn, has the farmers operating poultry facilities in the area worrying.
Owners of a big poultry facility, M A Poultry Farm with a rolling chicken count of 6,000, say they have feed stock for only another week.

"How are we going to feed the chickens if the Government doesn't allow feed to come into the state? All our feed comes from outside and we need between 200-300 kg of feed everyday. If deprived of food, the chickens will start devouring each other. It'll be a total loss," says Ambala, a veterinarian who changed professions a decade ago when the Khuraijams entered the poultry business. Culling, it seems, would have been more remunerative although the government is giving only Rs 30 as compensation per full grown broiler chicken.

This prevailing situation outside has prompted around 250 poultry farmers to come together and form the All Manipur Poultry Farmers and Traders Association, brought into being on July 30. The Association wants the Government to understand its plight and are submitting a memorandum to Governor Dr S S Sidhu urging that culling be completed at the earliest and the region declared free of bird flu so that the markets can start functioning again.
 

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Burma Can Control Bird Flu Outbreak, UN Says

http://www.irrawaddy.org/article.php?art_id=8126

By Khun Sam
August 6, 2007

August 06, 2007—Military-ruled Burma has had several outbreaks of H5N1 bird flu virus since early 2006, but it is taking the necessary steps to combat the bird flu virus, according to an official from the UN Food and Agriculture Agency.

Tang Zhengping, a Rangoon-based representative of the FAO, said, “I think they are following the guidelines recommended by FAO and (other UN agencies). They destroy all the poultry in the affected poultry farms, and they take the necessary measures to control the disease.”

“They (Burmese authorities) also support the disease control messages,” Tang Zhengping told The Irrawaddy o*n Monday.

“With the international organizations’ assistance, yes, I think they have the capacity to control and prevent such outbreaks and the further spread of the virus,” he said.

As part of measures against H5N1 virus outbreaks, the Burmese junta o*n Saturday banned poultry imports from India due to an outbreak of bird flu last month in the neighboring country.

Myanmar’s Livestock Breeding and Veterinary Department said in a report in the state-run Burmese language newspaper The Mirror that Burma’s western and northern regions are clear of the virus and urged local authorities and residents to report poultry imports from the neighboring country and urged quick reports of any mass poultry deaths.

In late July, India reported an outbreak of bird flu in northeastern Manipur State which borders o*n Burma. Indian authorities last week identified 28 more villages as slaughter operation zones and reportedly culled about 30,000 birds.

“The Indian side has the bird flu outbreak, so they (Burmese authorities) should also have bans o*n poultry importation,” Tang Zhengping said.

A fresh bird flu outbreak was reported in southeastern Burma’s Mon State o*n July 24 and a second outbreak in less than a month in Pegu Division. In the two outbreaks, more than 5,000 poultry were culled. Previous cases in 2007 were reported in Rangoon in February and March.

“We tried to identify where this virus came from, but it is still difficult to find the source. But at least we can say the bird flu virus is still in Myanmar,” Tang Zhengping said.

He said Burma’s western and northern regions, including Chin and Kachin states, have had no reports of the bird flu virus.

No human cases of the H5N1 virus have been reported in Burma.

The World Health Organization says that since the bird flu virus outbreak in 2003, the virus has infected at least 319 people worldwide and killed at least 192.
 

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WHO: Indonesia hampering bird flu effort

http://www.businessweek.com/ap/financialnews/D8QRNJF80.htm

By ERICA BULMAN

GENEVA

Indonesia has yet to resume sharing samples from human bird flu victims with the World Health Organization, jeopardizing not only the Asian nation but the entire planet, the U.N. health agency said Monday.

David Heymann, assistant director-general for communicable diseases at WHO, said the agency had received three specimens from Jakarta in May, but none contained any live virus.

"What's important is that all countries share viruses that they isolate from humans," Heymann said.

"By not sharing the viruses, Indonesia is ... putting in danger its own populations, because if those viruses are not freely shared with industry, vaccines will not contain the elements of the Indonesia infections. The second thing that Indonesia is doing is therefore putting the whole world at risk."

Indonesia -- the nation hit hardest by the deadly H5N1 strain of bird flu -- stopped sharing its samples with international scientists searching for mutations early this year because Jakarta wanted assurances that any vaccines developed would not be too expensive for developing nations.

It ended its boycott in May, however, after receiving assurances from WHO that the virus samples would be used for risk assessment and not passed on to private pharmaceutical companies without Jakarta's permission.

China -- which had not shared H5N1 specimens with WHO for almost a year -- sent bird flu samples in June. Vietnam has sent samples but has encountered shipping road blocks, Heymann said.

Heymann said he was optimistic Indonesia would come around.

"They understand these issues," he said.

The H5N1 virus has killed at least 192 people, largely in Asia, since late 2003, according to WHO.

So far, the virus remains hard for people to catch, but experts fear it will mutate into a form that spreads easily among humans, potentially sparking a pandemic. Currently, most human cases are linked to contact with infected birds.

Health experts met in Singapore last week to discuss virus sharing. WHO's 193 member states will examine the issue at the World Health Assembly, scheduled to meet next May.
 

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China goes all out to prevent epidemics before 2008 Olympics

http://mangalorean.com/news.php?newstype=local&newsid=49811

Beijing, Aug 7 (Xinhua) China has set up an extensive network to monitor potential epidemic outbreaks before and during the 2008 Olympic games to ensure public health security, an official with the Chinese Center for Disease Control and Prevention (CDC) said here Tuesday.

"The country has developed an extensive monitoring network that is quick to react to the outbreak or any sign of an outbreak of epidemic diseases," said Dong Xiaoping, a section chief with CDC, at a symposium.

The network connects hospitals, government bodies and medical experts with the public, so that information on epidemics at home and abroad could be updated promptly, he said.

The prevention and control of bird flu will be a top priority.

Dong said the government would have a strategic supply of vaccines as the most effective solution for potential epidemics.
 

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DA temporarily bans all bird, poultry imports from Nebraska, Virginia

http://www.pia.gov.ph/default.asp?m=12&fi=p070807.htm&no=77

Manila (7 August) -- The Department of Agriculture (DA) has imposed a temporary ban on all imports of domestic and wild birds along with poultry and its products from Virginia and Nebraska following official confirmation by United States authorities of the presence of the avian influenza (AI) or bird flu virus in these American states.

This latest ban was based on a July 23 report submitted by Dr. John Clifford, the deputy administrator of the Animal and Plant Health Inspection Service of the US Department of Agriculture to the Office International des Epizooties (OIE) or Animal Health Organization, on the presence of low pathogenic strains of the AI virus H5N1 in Virginia and H7N9 in Nebraska.

Agriculture Secretary Arthur Yap said the this ban and other emergency measures were necessary to protect human health and the poultry industry in the Philippines, which has remained free of bird flu ever since the H5N1 strain of this virus resurfaced in Asia in 2003.

The Philippines is one of only three AI-free countries in Southeast Asia, the two others being Brunei and Singapore.

"I have ordered DA quarantine officers and inspectors at all major airports and seaports to stop and confiscate all shipments of live birds, poultry and poultry products into the country originating from Nebraska and Virginia."

Yap said the ban covers all "domestic and wild birds and their products, including day-old chicks, eggs and semen."

In his directive, Yap also ordered the immediate suspension of the issuance of Veterinary Quarantine Clearances (VQCs) to all imports covering these products from Togo.

The DA had earlier imposed a similar ban on all live bird and poultry imports from Korea, the United Kingdom and Japan after the presence of the bird flu virus was also detected in these countries.

The ban against Japan has since been lifted last May following an evaluation made by the Bureau of Animal Industry (BAI) that the risk of AI contamination from bird and poultry products originating from that country was negligible.

As of end-July, the World Health Organization (WHO) had reported that 191 out of 317 people found in laboratory-confirmed cases to have been infected with the AI virus have died since the H5N1 strain of the bird flu virus resurfaced in Southeast Asia in 2003 and then spread across the rest of the continent, Europe, the Middle East and Africa.

This cumulative number represents a 60% human mortality rate from this virus.

WHO experts have expressed concern over the possibility that every additional human infection gives the virus a greater opportunity to mutate into a deadlier strain that will make it easier for AI to jump from fowls to humans and then from person to person, which could lead to a pandemic.

Tens of millions of people combined were killed during the three pandemics that swept across the globe during the past century. (PIA-MMIO) [top]
 

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'RI will only share bird flu virus sample under new mechanism'

http://www.thejakartapost.com/detailgeneral.asp?fileid=20070807170918&irec=0

JAKARTA (JP): A health ministry official says Indonesia will only resume sending live virus sample of the avian influenza to the World Health Organization (WHO) once a new mechanism on virus sharing approved.

"We will stick to the resolution and wait until new mechanism is approved after an inter-governmental meeting in Geneva in November," health ministry's spokesperson Lily Sulistyowati told The Jakarta Post Tuesday.

"However, anyone who needs the virus can file a special request to us officially," she said.

The Associated Press reported Tuesday that David Heymann, assistant director-general for communicable diseases at WHO, said WHO had received three specimens from Jakarta in May, but none contained any live virus.

Indonesia, the hardest hit nation which recorded 82 casualties out of 101 infected people, stopped sharing its samples of H5N1 strains with WHO early this year following the finding that an Australian pharmaceutical company had used the virus without Jakarta's permission.

It ended its boycott in May, however, after receiving assurances from WHO that the virus samples would be used only for risk assessment and not passed on to private pharmaceutical companies without Jakarta's permission.

Lily confirmed that the ministry had sent its virus in May, but could not understand why the health organization did not make any complaint earlier.

WHO has called Indonesia could jeopardizing not only the Asian nation but the entire planet by not sharing its samples from human bird flu victims.

"By not sharing the viruses, Indonesia is ... putting in danger its own populations, because if those viruses are not freely shared with industry, vaccines will not contain the elements of the Indonesia infections. The second thing that Indonesia is doing is therefore putting the whole world at risk,"Heymann said.

Heymann said that China - which had not shared H5N1 specimens with WHO for almost a yearsent bird flu samples in June. Vietnam has sent samples but has encountered shipping road blocks.

He said he was optimistic Indonesia would come around as "They understand these issues." (Titin Wayansari)
 

JPD

Inactive
Bird flu kills Vietnamese student: state media

http://news.yahoo.com/s/afp/20070807/hl_afp/healthfluvietnam

HANOI (AFP) - A Vietnamese student has died from the H5N1 strain of bird flu, the country's fourth victim of avian influenza this year, state media reported on Tuesday.

The 15-year-old victim's family had kept ducks at their home in Thanh Hoa province south of the capital Hanoi, the state-run Vietnam News Agency reported.

The death, which could not immediately be verified with government officials, would bring to 46 the number of people who have died of bird flu in Vietnam since the killer virus broke out here in late 2003.

Communist Vietnam, once the nation worst hit by bird flu, contained earlier outbreaks through mass vaccination campaigns, the culling of millions of poultry and public education initiatives.

But the virus resurfaced strongly earlier this year, especially among waterfowl, hitting scores of poultry farms in an outbreak that at its peak in May spread to 18 of Vietnam's 64 provinces and municipalities.

As of this week, only three provinces remained affected, and 160 million head of poultry had received bird flu shots in the year's first round of vaccinations which was ongoing or finished in all provinces, officials said.

The World Health Organisation (WHO) had recorded 319 cases of bird flu in humans worldwide, 192 of which were fatal. The Geneva-based body has yet to confirm the latest death in Vietnam with laboratory tests.

Experts fear the global death toll could rise sharply if the virus were to mutate and become easily transmissible between humans, leading to a global pandemic with the potential to kill millions.

Last week WHO spokesman Gregory Hartl said global bird flu cases appeared to have stabilised among humans but that several developing nations had not been able to stem its spread among poultry and domesticated birds.

"The number of human cases of bird flu appears to be stable when compared to the same period last year," Hartl said. "In the northern hemisphere, the number of cases in summer has declined marginally from the winter.

"Human to human transmission are very rare. We think there have been three cases -- in Vietnam, Cambodia and Indonesia. And each time the person has had prolonged and direct contact with an affected person," Hartl said.

World Bank vice president for East Asia and the Pacific James Adams, speaking earlier Tuesday during a visit to Hanoi, warned that the bird flu threat remained.

"The magnitude of the challenge in this region is exceptional because this is a region where livestock lives in close proximity to the human population," he told a Hanoi media briefing.

"We are trying to emphasise from the development side that the needs of the veterinary systems and the health systems do need to be pushed and have to be reinforced."
 

JPD

Inactive
Study: Quarantines Work Against Pandemics

http://www.time.com/time/health/article/0,8599,1650634,00.html?xid=rss-health

On the medical front, the U.S. has never been particularly good at prevention. The tack, usually, is to patch people up as they get sick, rather than keeping them from falling ill to start. But no Band-Aid is sufficient to handle a lethal pandemic, which some experts say is inevitable — if not imminent. Whether it's bird flu or some other deadly knock-out germ that eventually sweeps through the country, scientists and public-health researchers are trying to prepare for it now to ensure that everyone has a better chance of survival.

To plan for the future, researchers in Michigan went straight to the past. Led by Dr. Howard Markel, director of the University of Michigan Medical School's Center for the History of Medicine, a team of public-health experts evaluated the U.S. response to the world's last great pandemic — the Spanish flu in 1918. The new report, published in the Aug. 8 issue of the Journal of the American Medical Association, analyzed the public-health measures taken by 43 U.S. cities, all with populations greater than 100,000, during the six months between Sept. 1918 and Feb. 1919. Markel found that cities that early on adopted "old-fashioned," non-pharmaceutical interventions — such as school closures, social-distancing in the community and workplace and quarantine — and "layered" multiple interventions at once for a long period of time fared better than other cities, with slower rates of infection and lower rates of death.

"The conventional wisdom had been that cities [in 1918] had done everything they could and nothing worked — it was all doom and gloom and dread and nothing to do but throw up our hands in despair," says Dr. Martin Cetron, director of the Division of Global Migration and Quarantine at the Centers for Disease Control and Prevention (CDC), and a senior author of the study. "This study gives us real reason for optimism, that even reaching back to a time where there were no antiviral medications and no well-matched vaccines to fight a pandemic, the things communities did in terms of traditional public health tools — isolation, quarantine, social-distancing, canceling schools — made a big difference and have a lot of potential to mitigate the severity of a lethal disease pandemic."

That's good news, considering that the U.S. has purchased only 26 million doses of the newly licensed H5N1 flu vaccines, enough to cover 13 million people in the event of a pandemic —but there's no guarantee that H5N1 will even be the bug in question. In 1918 the Spanish flu infected 20% of the world's population and killed 40 million people (a mortality rate of 2.5%), and 550,000 of those deaths were in the U.S. What the new study illuminates is the small print behind that big number: some cities got hit much harder than others, and there's a lot to be learned from the way they each responded to the same threat.

Markel and colleagues divided the cities' interventions into three major categories: school closure, cancellation of public gatherings, and isolation and quarantine. During the 24 weeks researchers studied, there were 115,340 excess deaths due to pneumonia and influenza in 43 states, with a collective population of about 23 million. New York City responded to its earliest sign of infection with isolation and quarantine over a sustained period of time, beginning 13 days after the first case was detected, and had the lowest pandemic-related death rate of any city on the East coast. By contrast, Pittsburgh reacted late, waiting one month, and suffered the greatest number of excess deaths from the disease. In both cities, however, interventions were used singly rather than as a combined approach. St. Louis layered its interventions, using the various social-distancing measures at once, 2.5 weeks after its first case of infection; that tactic mitigated the outbreak and St. Louis fared better than 36 other communities as a result. Researchers compare layering interventions to layering Swiss cheese: if the holes are vulnerabilities, with enough layering you'll end up with a solid block of prevention.

Though Markel's study has just been published, it has already been rolled into policy. The Department of Health and Human Services and CDC finished their analysis of the study's data last December before incorporating it into the Community Strategy for Pandemic Influenza Mitigation, a collection of guidelines for use by individuals and communities issued by the agencies in February. The guide offers help in coordinating and implementing a strategy to protect communities from the front end of an epidemic and to keep them afloat until the appropriate pandemic-strain vaccine can be delivered to them — which officials estimate will be four to six months after the first case is identified.

The context of the 21st century, however, is very different from that of 1918. Individual rights are guarded a lot more fiercely today than in the past, and people may not submit easily to compulsory quarantine or isolation. It is critical that if we were to implement such public health measures that we have adequate medical and psychological support, says Markel. "If you come down with the force of the law very hard, you have to ask if the public health edict helps public health or endangers it," he says. "The onus is on us as physicians, public health experts, government public health officers at the city, state and federal levels to embark on a huge educational campaign."

These days, too, travel — and spread of disease — is faster, but so is communication. The medical community can share information more quickly. Accordingly, there's more pressure for better and faster detection of infection. "Early needs to be earlier because things move much more rapidly," says Cetron. "It means not waiting until that death curve doubles. We want the trigger to be the first outbreak or cluster of cases of the pandemic strain in a community or state."

He adds: "We're probably the first generation in history to have the benefit of hindsight and time to plan for the future, not only to implement the measures effectively but to plan for the adverse unintended consequences of social-distancing strategies," says Cetron. Now that sounds a lot like prevention.
 

JPD

Inactive
Bird samples from Tripura tested negative for avian influenza

http://www.newkerala.com/july.php?action=fullnews&id=52388

New Delhi, Aug 7 : The samples of birds sent to the High Security Disease Laboratory (HSADL) in Bhopal from Tripura for test of Avian Influenza virus were today found negative.

The samples were sent from Dibyoday Krishi Bigyan Kendra, Khowai under West Tripura District.

Meanwhile, the samples from Vawmbuk village in Mizoram's Saiha District are under test at HSADL.

The Centre on Friday said that there were no suspected human cases of bird flu and the situation in Chingmeirong village in Manipur, where the outbreak of the bird flu was confirmed on July 25, was completely under control.

There were reports earlier that four people in the area who had come in contact with the infected birds were suffering from fever or Acute Respiratory Tract Infection (ARI).

The samples of those people sent for medical examination to National Institute of Virology in Pune and National Institute of Communicable Diseases in Delhi were also found negative for Avian Influenza virus.

Close to two lakh birds have been culled in the State, and the Centre has already alerted neighbouring Mizoram to check illegal smuggling of hens from across Myanmar where incidents of bird flu outbreak have occurred very often.

--- ANI
 

JPD

Inactive
Bird flu drill prepares hospitals for the real thing

http://www.naplesnews.com/news/2007..._prepares_hospitals_real_thing/?breaking_news

By JESSICA COSDEN contact

Tuesday, August 7, 2007

A woman walked into the Cape Coral Hospital emergency room Tuesday afternoon complaining of a fever and nasty cough. Throughout her stay, her condition would demand the resources and energy of nearly every department in the hospital, from the emergency room to the morgue. The health department and Centers for Disease Control would also be involved.

Emergency room nurse Trish Laub, left, diligently takes notes as she plays the victim and is whisked out of the emergency room and to the intensive care unit by ER director Polly Spate, center, and respiratory therapist Nicole Noonan, right, at Cape Coral Hospital on Tuesday. They were participating in a mock drill centered around two cases of bird flu. Lee Memorial Health Systems staged the pandemic drill at the hospital to assess the needs of hospital patients and employees in the event of a bird flu case.

It was all part of an avian flu exercise, the first of its kind in Southwest Florida. Health officials are no longer questioning whether the bird flu pandemic could hit the area; it’s more a matter of when.

The question is this: how prepared are we?

Tuesday’s scenario gave hospital staff a glimpse.

It was one of four drills taking place this week at the hospitals of Lee Memorial Health System, said coordinator Connie Bowles. Hospital employees coordinated with the county health department for the exercise.

“This was to raise awareness, to stimulate conversation and thought,” said Bowles, a registered nurse. Officials have been working on plans to apply in an actual incident, and what they learned Tuesday will be included in those plans, she said.

For the past three weeks, Bowles set hospital employees up for the drill. They were initially sent an e-mail describing a bird flu pandemic in Europe. The second week, doctors and nurses were informed the flu it had made its way to the United States. Finally, last week, the bird flu was reported in Florida.

Tuesday’s scenario: a woman’s son has just returned from Germany, where a bird flu pandemic recently struck. The woman is showing all the symptoms.

In a real case, said Bowles, the patient would have been put into a negative pressure room immediately. Only one nurse would treat her in order to limit exposure.

The pretend patient was immediately seen by Dr. Timothy Dougherty, who suspected bird flu because of her symptoms and her son’s recent visit to Europe. Dougherty ordered routine blood work, a quick influenza test, antibiotic treatment, Tamiflu, and a chest X-ray.

He also directed the nurse to contact the health department. Only the health department is able to take test samples for the diagnosis of bird flu, Bowles said.

Communications between hospital and health department went glitch-free.

“They got back with us in a timely manner,” Bowles said.

In reality, the test sample would have been flown to a lab in Tampa, with results in as soon as four hours.

Dougherty said the first alarm was the patient’s list of symptoms in the middle of summer. During winter months, Dougherty said, she may have been treated as a normal flu patient because it’s so common at that time.

“Bird flu can look just like a cold or regular flu,” Dougherty said.

During the summer, it would “raise our suspicion if we got seven or eight in one day, all with the same symptoms,” he said.

Soon after the mock patient was definitively diagnosed with bird flu with lab results, her condition quickly got worse. She was admitted and put in the intensive care unit but later “died.”

The drill ended after she was taken to the morgue.

“One person can affect all of the different departments,” Bowles said.

Obviously, the emergency room, intensive care unit and morgue were affected. But so were X-ray, central supply for provisions like masks, pharmacy for Tamiflu and other drugs, and plant operations, whose workers can convert a room or unit to negative pressure if needed.

A new experience for all involved — Lee Memorial Health System has conducted mass casualty, bioterror, and trauma drills in the past, but nothing like this — the drill gave health officials plenty to think about.

“It elicited more questions than providing answers,” Bowles said. “This is something we’re not used to dealing with.”
 

JPD

Inactive
H5N1 outbreaks in poultry could be 'tip of iceberg'

http://www.thejakartapost.com/detailcity.asp?fileid=20070808.H04&irec=3

The Jakarta Post, Jakarta

Avian influenza has killed no less than 500,000 chicken in Greater Jakarta in the last six months but not all outbreaks are reported to the health authority, a veterinarian says.

Roeslan Isdhianto said Tuesday the data was collected from 10 poultry farmers -- all of whom own 100-200 chickens on average -- in Jakarta, Tangerang, Bogor and Bekasi.

The Bogor-based veterinarian said the farmers had told him cases were not being detected by the health authority because there was a shortage of field officers.

Bird flu was first reported in poultry here in 2003 in Central Jakarta. The government says it has complied with World Health Organization standards for handling bird flu outbreaks by vaccinating healthy poultry and culling infected birds and birds within a one-kilometer radius of affected poultry farms.

There have been 81 confirmed deaths from bird flu in the country. This is the highest number of deaths from the disease of any country in the world.

Roeslan said the government had taken the wrong approach to vaccinating birds.

"The government doesn't have a firm stance in its vaccination policy," Roeslan said as quoted by Antara.

"At present, there are 15 kinds of vaccine for the three AI subtypes of H5N1, H5N2 and H5N9. The government hasn't clearly ruled which of the three is most suitable for our AI cases here," he said.

Roeslan said none of the vaccines on the market had been properly evaluated.

"Monitoring and evaluating the performance of the vaccines already in use is important," he said.

In January, bird flu outbreaks were reported in 43 subdistricts of Bogor. However, due to a lack of monitoring, there have been no reports on whether the areas are now "disease free".

Heru Setijanto, a veterinarian with the Bogor Institute of Agriculture, warned that the bird flu cases could be the tip of the iceberg.

"Chickens die everywhere. The problem is the deaths are not always reported," he said.

Heru conceded there were shortages of veterinarians in the field as nationwide there were only 200 animal health posts.

"Half of the posts are not functioning."

Ideally, each district should have an animal health post overseen by a veterinarian, Heru said.
 

JPD

Inactive
CytoDyn DNA Vaccine Shows Promise for
Low-Dose Protection from Bird Flu, Reliable Supply​

http://news.moneycentral.msn.com/provider/providerarticle.aspx?Feed=BW&Date=20070808&ID=7295711

CytoDyn, Inc. (PINK SHEETS: CYDY) has completed analysis of its prospective, placebo-controlled study that used mice to compare nine variations of experimental DNA vaccines for the bird flu. Mice are the standard animal model for pre-clinical studies of human flu vaccines. Three of the vaccines given at a relatively low dose caused mice to develop antibodies against the bird flu (H2 subunit of HA H5) at a significant level (detectable at a dilution of 1:12,500). The three vaccines were:

1. The vaccine that the Company obtained from the University of Massachusetts Medical School (UMMS).

2. A vaccine based on the UMMS product that the Company had enhanced using the latest method of improving DNA vaccines (CpG motif).

3. A similarly enhanced bird flu vaccine from a company that makes DNA vaccines for protecting animals.

All three appeared to be equally effective in terms of the quantity of antibodies produced, although, without enhancement, the UMMS vaccine appeared to be somewhat less potent in other respects. However, vaccines based on the UMMS product, including the Company's enhanced vaccine, appear to work faster (because of a codon optimized Vietnam 1203 HA gene). Faster action could be an advantage because public health officials are unlikely to vaccinate large populations against the bird flu before a pandemic of bird flu has actually broken out. Once a pandemic has started, there will be a need to protect the human population as quickly as possible.

These results are only preliminary but will guide market strategy for the Company's vaccine, according to CEO Allen D. Allen. He will be discussing vaccine markets on a live webcast scheduled for August 10, 2007 at 12:30 PM EST on Market News First.

Competition or Collaboration?

Much fanfare has surrounded the gene gun being developed by PowderMed, a wholly owned subsidiary of Pfizer PFE. The gene gun is used to deliver a DNA vaccine for bird flu directly into human cells thereby increasing potency, albeit at the expense of creating massive new inventories of the device to replace the ubiquitous hypodermic. PowderMed's DNA vaccine is reported to be an older version of the UMMS vaccine without enhancement. Consequently, successful development of CytoDyn's more effective DNA vaccine could provide PowderMed with a means of competing against the traditional vaccines under development at major pharmaceutical companies since these may be sufficiently potent for administration with a hypodermic.

One such vaccine was recently licensed by the FDA for marketing by Sanofi-Avantis SNY but only protected 45% of those vaccinated in clinical trials. On the other hand, GlaxoSmithKline GSK reports a proprietary adjuvant that protected 80% of subjects in preliminary clinical trials. (An adjuvant is a chemical that stimulates the immune system and can make vaccines work better.) Likewise, BioSante BPA found that its adjuvant doubled the potency of bird flu vaccines in mice. It is likely that all flu vaccines will eventually use an adjuvant to make them more potent. None will have the advantages of a potent DNA vaccine. But the two types of vaccines could be used together to provide the best option of all.

Animal studies conducted by UMMS have shown that DNA vaccines and traditional vaccines could be used together to reinforce each other with the proprietary version of "prime/boost" licensed exclusively to CytoDyn by UMMS. Prime/boost more generally refers to administering a DNA vaccine, waiting for an appropriate amount of time to elapse, and then boosting the vaccine with a protein. Consequently, CytoDyn's product could wind up being used in conjunction with traditional bird flu vaccines, as opposed to being a competing product.

About DNA Vaccines

There are several advantages to DNA vaccines because they are engineered in the laboratory and do not contain viruses that require strict manufacturing, transportation, and storage conditions like traditional vaccines. Anthony S. Fauci, M.D, Director of the National Institute of Allergies and Infectious Diseases (NIAID) said, "More broadly, development of this (bird flu) DNA vaccine technology has the potential to improve our production capacity for vaccines to prevent seasonal influenza and other diseases."

Several DNA vaccines have been developed that protect avian species and some mammals other than humans. The challenge has been to develop DNA vaccines that protect humans as effectively as they protect animals. A potential path for making progress in this regard is to reach beyond the traditional goal of creating antibodies to include the cell-mediated immune response as well. The NIAID tried this while developing an experimental DNA vaccine that protects mice from the virus that caused the flu pandemic of 1918, albeit with antibodies alone, and the CDC has encouraged such research. The latest approach uses a recent discovery about the immune system known as CpG motif. In CytoDyn's study, this enhancement increased cell-mediated immunity 4-fold in mice. However, the more apparent effect was to stimulate B cells, the cells of the immune system that make antibodies.

Disclaimer

This press release contains forward-looking statements that are not historical facts. The Company's management makes forward-looking statements concerning the Company's expected future operations, performance and other developments. These forward-looking statements are necessarily estimates based upon current information and involve a number of risks and uncertainties, including but not limited to, the failure of preliminary results from scientific studies to reflect the results from more comprehensive studies. There can be no assurance that such risks and uncertainties, or other factors, will not affect the accuracy of such forward-looking statements. It is impossible to identify all factors that could cause actual results to differ materially from those estimated by the Company. They include, but are not limited to, government regulation, managing and maintaining growth, victimization by white-collar offenders, and the effects of adverse publicity, litigation, competition, and other factors that may be identified from time to time in the Company's announcements. Contact Information: CytoDyn, Inc. Stacia Andrews, 505-988-5520 or Corinne Allen, 505-988-5520 info@cytodyn.com
 

JPD

Inactive
Nebraska poultry with bird flu headed to food supply

http://www.kotatv.com/Global/story.asp?S=6905640&nav=menu411_2

Associated Press - August 8, 2007 4:55 PM ET

LINCOLN, Neb. (AP) - Agriculture officials say they have no concerns about sending turkeys that carry a mild strain of bird flu into the food supply.

A flock of turkeys in Seward County tested positive for the disease, prompting four countries to temporarily ban the import of Nebraska poultry.

Deputy state veterinarian Del Wilmot says the flock shows no sign of illness and is being prepared for processing.

Karen Eggert is with the U.S. Department of Agriculture's Animal and Plant Health Inspection Service. She explains that the turkeys tested positive for the antibodies that indicate a possible exposure to bird flu. That doesn't mean they carry the virus.

Eggert notes that humans cannot get sick from poultry that carries bird flu if it is cooked to the USDA's minimum internal temperature recommendation of 165 degrees.

On the Net:

Nebraska Department of Agriculture: http://www.agr.state.ne.us/

U.S. Department of Agriculture: http://www.usda.gov/
 

JPD

Inactive
Nebraska Poultry Banned By Four Countries

http://www.yankton.net/stories/080907/new_189911549.shtml

By: Timberly Ross

LINCOLN, Neb. -- Four countries have temporarily banned the import of Nebraska poultry after a turkey flock in Seward County tested positive for a mild strain of bird flu.

Deputy state veterinarian Del Wilmot said Wednesday that the flock shows no sign of illness and was being prepared for slaughter and entry into the food supply.

The U.S. Department of Agriculture and trade groups for the poultry industry have said no human cases of bird flu have ever been traced to eating properly cooked poultry or eggs.

But officials in Japan, Russia, Turkey and the Philippines are taking no chances. Wilmot said those countries have barred all poultry and related products, such as eggs, coming from Nebraska.

"This ban and other emergency measures were necessary to protect human health and the poultry industry in the Philippines," Arthur Yap, agriculture secretary for the Asian country, said in a news release issued Tuesday.

Yap ordered inspectors at the country's major airports and seaports to confiscate all poultry shipments from Nebraska and Virginia, which last month faced a domestic band on live poultry sales after 54,000 turkeys tested positive for avian flu antibodies.

The Philippines is among three countries in Asia -- the area with the greatest number human cases -- to remain free of bird flu since 2003.

"The restrictions these countries have placed have absolutely nothing to do with science," said Toby Moore, a spokesman for the USA Poultry and Egg Export Council.

Karen Eggert, with the USDA's Animal and Plant Health Inspection Service, said the department has no qualms about sending the Seward County turkeys into the food supply. She explained that the turkeys tested positive for the presence of antibodies that indicate a possible prior exposure to an H5N1 avian influenza virus that does not pose a threat to humans.

She noted that humans cannot get sick from poultry that carries bird flu if it is cooked to the USDA's minimum internal temperature recommendation of 165 degrees.

The flock's positive results came back in June, when the Nebraska Department of Agriculture administered its routine testing for the disease, said state veterinarian Wilmot. How those birds contracted the disease was not known, but Wilmot said it could have been from contact with waterfowl, which often carry a form of bird flu.

"When all these birds are off the farm and the place is clean and disinfected, we'll notify the USDA," said Wilmot.

As part of international trade agreements, the USDA notifies foreign countries of the presence of bird flu -- and its absence. Once the all-clear notification goes out, the ban will likely be lifted.

In the Nebraska, the poultry industry is estimated to account for $1.35 billion of the state's economy each year. It was not known Wednesday what impact the temporary bans will have.

Mark Witmer, a spokesman for Micheals Foods, a Minnetonka, Minn.-based company that has an egg processing facility in Wakefield, said Wednesday that he didn't know about the bans and hadn't noticed any effect on the business.

The H5N1 virus has killed at least 192 people worldwide since 2003, according to the World Health Organization.

It remains hard for humans to catch, but experts fear it could mutate into a form that spreads easily among people, potentially sparking a global pandemic. So far, most human cases have been traced to contact with infected birds.
 

JPD

Inactive
Vietnam home to world’s highest number of human bird flu cases

http://www.thanhniennews.com/healthy/?catid=8&newsid=30838

A total of 100 Vietnamese people had been infected with the deadly H5N1 bird flu virus, the highest number in the world, according to the World Health Organization.

The global health body (WHO) said Vietnam ranks second in the world in terms of human avian influenza deaths, with 46 cases after Indonesia with 63.

The WHO announcement came after Vietnam recorded its fourth bidr flu death of 2007 on August 3.

Head of the Vietnam’s Preventive Heath Department Nguyen Huy Nga said Wednesday that the Ministry of Health had seen no major gene changing in the country’s virus samples in most recent tests.

The H5N1 bird flu virus claimed the life of a 15-year-old boy from northern Thanh Hoa province last week, marking the country’s fourth avian influenza death out of seven infections since May.

Last month, bird flu took a 22-year-old pregnant woman’s life at Hanoi’s Bach Mai Hospital

In June, a 20-year-old man and a 28-year-old woman were killed by the virus.

Last year, Vietnam had been praised by the international community for curbing the spread of bird flu through a nationwide poultry vaccination campaign.

No human cases were reported in the country in 2006, but the virus struck again early this year, forcing the slaughter of more than 200,000 birds.

Vietnam’s first human infection occurred in late 2003. Since then, the Southeast Asian country has recorded 100 human infections in 33 provinces and cities.

Forty six of the cases have proved fatal.

The World Health Organization recently said that 192 of the world’s 319 human infections had caused death by July 25
 

JPD

Inactive
Australia

Mutant flu kills six

http://www.news.com.au/dailytelegraph/story/0,22049,22218368-5001021,00.html



By Clare Masters

August 10, 2007 12:00am

A DEADLY flu epidemic is sweeping the country with six people - including five children - killed by a mutant strain of the already deadly influenza A virus.

While it was first feared young children were the most susceptible to the virulent strain, father-of-three Glen Kindness became the first adult to fall victim to the flu.

Doctors across the state are reporting patients presenting with "moderately severe" cases of the flu.

The number of people falling ill with the flu in NSW has almost doubled over the past year, with six out of every 1000 presenting at emergency departments with symptoms including fever, headaches, muscle and joint pain and sore throats.

While no NSW deaths have been reported, the state's hospitals are on high alert as worried parents swamp emergency departments.

A Sydney Children's Hospital spokeswoman said their emergency department had seen a 69 per cent rise in respiratory conditions since last year and a 218 per cent increase in viral infections.

Influenza A is the more deadly strain of the flu virus - mainly affecting the throat and the lungs - but it can also cause heart problems.

This year the strain has mutated into a tougher form that is harder for people to resist - particularly the very young and the very old.

"It has to do with the general population's immunity to a particular strain - it mutates a little bit every year to evade the general population's immune system," NSW Health's director of communicable disease Dr Jeremy McAnulty told The Daily Telegraph.

Experts say children under five are the most- susceptible to the virus because their immunity has not built up.

Despite the deaths of five children across three states over the past month, doctors last night said deaths from the flu were rare.

"While they (flu-related deaths) do occur and they are frightening, they are a rare event. Parents need to be alert but not alarmed," Professor Leon Piterman from Monash University said.

Dr McAnulty said parents should be vigilant and alert to any changes in their child's behaviour.

He said worried parents should take their children to their local GP first, but if it is an emergency then they should go straight to their local hospital.

Health authorities are cautioning parents not to panic, with early figures suggesting the flu spike is subsiding.

Mr Kindness, a former soldier, last Tuesday became the first adult to die of influenza A.

The 37-year-old, who served two tours in East Timor, died just three hours after being rushed to Blackwater Hospital in Queensland suffering flu-like symptoms.

His devastated widow Kathleen last night said she was shocked at the suddenness of her husband's death.
 

JPD

Inactive
More dead birds in Germany, suspected bird flu

http://www.worldpoultry.net/news/id2205-26226/more_dead_birds_in_germany_suspected_bird_flu.html

10 Aug 2007

Authorities in Bavaria have confirmed that more wild birds have been found dead in Germany due to the H5N1 bird flu virus.

According to police in the southern state, movement restrictions have been put in place around the Speichersee lake where two out of three ducks found dead were confirmed to have been carrying the deadly virus.

Press reports have stated that about 14 other birds have also been found dead in the area, however, it is not known if they are infected with the virus.
It was the first time in 2007 that the H5N1 strain of bird flu has been found among domestic birds in Germany. Scientists suggest that it could have jumped the border from the neighbouring Czech Republic where there were infected poultry.
 

JPD

Inactive
Mutant flu virus may show how pandemic could start

http://www.ajc.com/metro/content/printedition/2007/08/10/fluresearch.html

By Jeff Nesmith
Cox Washington Bureau
Published on: 08/10/07

Washington —- Government scientists have created mutant viruses that may hold the key to understanding how the deadly H5N1 strain of bird flu might change into a disease that spreads from human to human.

The knowledge could open the door to more rapid vaccine development or ways to come up with pre-emptive vaccines and antiviral drugs before a pandemic begins, they say.

The World Health Organization has confirmed that 319 humans have contracted H5N1, mostly from contact with infected chickens, ducks and other fowl, killing 192 of them.

However, WHO says that the virus has not efficiently spread from person-to-person. But if unknown mutations convert H5N1 into a disease that can be easily transmitted among people, millions could die before a vaccine is ready.

Working with biochemists at Emory University in Atlanta, scientists at the National Institutes of Health have created mutant viruses that seem to have at least some of the necessary molecular wherewithal.

"Now we can begin, preemptively, to consider the design of potential new vaccines and therapeutic antibodies to treat people who may someday be infected with future emerging avian influenza virus mutants," said Dr. Anthony Fauci, director of the National Institutes of Allergy and Infectious Diseases.

"This research could possibly help to contain a pandemic early on," he added.

The discovery is being reported today in the journal Science by a team led by Dr. Gary Nabel, head of vaccine research in Fauci's agency, and Dr. David Smith of the Emory School of Medicine.

Nabel explained in an interview that the key appears to be in a portion of the molecules known as hemagglutinin that cover the surface of each flu virus and account for the "H" in H5N1.

These molecules have a "canyon and ridge" shape that allows them to fit onto "spikes" that appear on the outside of human or bird cells, he said. Once the virus locks itself to the human cell, it is able to go inside and cause the cell to create millions of influenza viruses, which lock onto other cells.

Nabel said that deep in the bottom of the hemagglutinin canyon, different strains of influenza viruses have different molecular patterns. These differences seem to determine whether the hemagglutinin will lock onto the spikes of the victim's cells.

Except in the relatively small number of cases where people have gotten bird flu, hemagglutinin in H5N1 will not bind to the "spikes" on human cells. The virus just slips off the human cells.

Using genetic engineering, Nabel's group made changes in the H5N1 form of hemagglutinin to see if the changes would cause it to bind to human cells. The mutated viruses were then sent to Emory, which maintains a "library" of molecules that appear on human cells.

By adding the mutated viruses to these molecules, the Emory group quickly established that the viruses attached themselves to a particular human molecule. It took only two of these mutations to change H5N1 into a virus that would readily lock onto human cells, Nabel said.

"While nobody knows if and when H5N1 will jump from birds to humans, [the researchers] have come up with a way to anticipate how that jump might occur and ways to respond to it," said Dr. Elias Zerhouni, National Institutes of Health chief.
 

JPD

Inactive
New vaccine may beat bird flu before it starts

http://www.reuters.com/article/healthNews/idUSN0923748420070809

By Maggie Fox, Health and Science Editor

WASHINGTON (Reuters) - Researchers studying bird flu viruses said on Thursday they may have come up with a way to vaccinate people before a feared influenza pandemic.

Experts have long said there is no way to vaccinate people against a new strain of influenza until that strain evolves. That could mean months or even years of disease and death before a vaccination campaign began.

But a team at the National Institute of Allergy and Infectious Diseases in Maryland and the Emory University School of Medicine in Atlanta said they may have found a short-cut.

The vaccine might protect people against the mutation that would change the H5N1 avian flu virus from a germ affecting mostly birds to one that infects people easily, the NIAID's Dr. Gary Nabel and colleagues report in Friday's issue of the journal Science.

"If we can define what changes need to be made to make that jump then we can target the immune system to that spot on the virus," Nabel said in a telephone interview.

"It gives us a chance to develop vaccines or monoclonal antibodies ... to really work in a preemptive way to be prepared."

Monoclonal antibodies, often used against cancer, are engineered immune system proteins that specifically attack proteins on a tumor or, in this case, on the flu virus.

"While nobody knows if and when H5N1 will jump from birds to humans, they have come up with a way to anticipate how that jump might occur and ways to respond to it," National Institutes of Health Director Dr. Elias Zerhouni said in a statement.

H5N1 remains mainly a virus of birds, but experts fear it could mutate into a form easily transmitted from person to person and sweep the world. It has occasionally infected people, killing 192 people out of 319 known cases since 2003, according to the World Health Organization.

To better try and understand the threat, researchers have studied various strains of H5N1 and compared them to the worst known flu virus ever -- the H1N1 virus that killed anywhere between 50 million and 100 million people in 1918 and 1919.

They found a mutation that makes one strain of the H1N1 virus more easily infect birds, and another one prefer humans. It lies in the part of the virus that attaches to cells in the respiratory tract.

They then made the same alteration in an H5N1 virus, and vaccinated mice with some of this genetically engineered H5N1 DNA.

They found an antibody that could neutralize both types of H5N1 -- H5N1 adapted to birds, and an engineered form that would in theory prefer humans.

"It delivers a powerful blow against this virus and really hits it where it lives," Nabel said.

If a vaccine could be designed to protect people against viruses with this mutation, it might be used before a pandemic even started, Nabel said.

A monoclonal antibody could be used to treat people who were already infected, he added.

Companies are making human vaccines against H5N1, but they are designed using the current strain of the virus, which does not easily infect humans. Scientists fear they are a poor match for any form of the virus that may eventually affect people.

Nabel said his team was working on some possible vaccines using the new approach.
 

JPD

Inactive
Scientists Target Future Pandemic Strains of H5N1 Bird Fl​
u


http://www.ens-newswire.com/ens/aug2007/2007-08-10-09.asp#anchor6

BETHESDA, Maryland, August 10, 2007 (ENS) - Preparing vaccines and therapeutics that target a future mutant strain of H5N1 avian influenza virus may be possible, even though such a strain does not yet exist, according to a team of federal government scientists.

To date, avian influenza has killed or caused to be culled hundreds of millions of birds, mostly chickens, ducks and geese, but it is mostly a disease that affects birds.

Worldwide, 319 human cases have been reported, and of these, 192 people have died, according to the World Health Organization.

But health experts are concerned that the H5N1 virus, given enough opportunities, will change into a form that is highly infectious for humans and spreads easily from person to person.

Such a change could mark the start of a global outbreak - a pandemic.

Success hinges on anticipating and predicting the crucial mutations that would help the virus spread easily from person to person, the scientists said today.

Led by Gary Nabel, MD, director of the National Institute of Allergy and Infectious Diseases' Dale and Betty Bumpers Vaccine Research Center, the team reports in the August 10 issue of the journal "Science" that they have developed a strategy to generate vaccines and therapeutic antibodies that could target predicted H5N1 mutants before these viruses evolve naturally.

This advance was made possible by creating mutations in the region of the H5N1 hemagglutinin protein that directs the virus to bird or human cells and eliciting antibodies to it.

"What Dr. Nabel and his colleagues have discovered will help to prepare for a future threat," says Elias Zerhouni, MD, director of the National Institutes of Health.

"While nobody knows if and when H5N1 will jump from birds to humans, they have come up with a way to anticipate how that jump might occur and ways to respond to it," Zerhouni said.

"Now we can begin, preemptively, to consider the design of potential new vaccines and therapeutic antibodies to treat people who may someday be infected with future emerging avian influenza virus mutants," said NIAID Director Anthony Fauci, MD.

"This research could possibly help to contain a pandemic early on."

Dr. Nabel's team vaccinated mice with material from viruses they altered to contain the mutant receptors, and they discovered one broadly reactive antibody that could neutralize both the bird and human adapted forms of an H5N1 virus.

Dr. Nabel said their findings should contribute to better surveillance of naturally occurring avian flu outbreaks by making it easier to recognize dangerous mutants and identify vaccine candidates that might provide greater efficacy against such a virus before it emerges.
 
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