9/2-8 | Weekly Bird Flu Thread: Indonesian bird flu victims fled from doctors

PCViking

Lutefisk Survivor
Posted on Sat, Sep. 02, 2006


Indonesian bird flu victims fled from doctors
PREVENTIVE MEASURES THWARTED
By Alan Sipress
Washington Post

JANDI MERIAH, Indonesia - Dowes Ginting, the most wanted man on Sumatra island, lay dying. He had abandoned the hospital where he had seen his relatives succumb one after another, and he had fled deep into the mountains, trying to outrun the black magic he feared had marked him next. For four nights, witnesses recalled, a medicine man hovered over him in a small clapboard home, resisting the evil spell.

Ginting, a wiry 32-year-old, had watched disease burn through his family over the previous two weeks, killing six and sickening two others, including himself. International health experts grew increasingly concerned when laboratory tests confirmed they were sickened by bird flu, the largest cluster of the disease ever recorded. But Dowes feared medical treatment more than he did the flu. And so he ran, potentially exposing villagers across the province to the highly lethal virus.

In the end, the outbreak in May did not presage the start of a worldwide epidemic. But the enormous difficulties that Indonesian and international disease specialists confronted in investigating the outbreak and protecting against its spread raised fundamental questions about whether bird flu could be contained if it mutated into a form more easily spread among people.

``If this were a strain with sustainable transmission from human to human, I can't imagine how many people would have died, how many lives would have been lost,'' said Surya Dharma, chief of communicable disease control in North Sumatra province.

Officials from the World Health Organization (WHO), drawing on sophisticated computer modeling of a theoretical bird flu outbreak in Southeast Asia, have suggested that a pandemic could be thwarted through a rapid containment effort in the affected area, including the right mix of drugs, quarantines and other social controls.

To succeed, the anti-viral drug Tamiflu would have to be distributed to 90 percent of the targeted population, roughly defined as those within at least a three-mile radius of each case. The drug would have to be administered within 21 days from the ``timely detection'' of the initial case of an epidemic strain. Residents would have to stay home, limit contact with others and take the medicine as prescribed.

In the case of the North Sumatra cluster, almost none of this happened, according to extensive interviews with health officers, family members and villagers. The underlying problem was that most family members and villagers were convinced that magic, not flu, was to blame.

``How can you ever get people to cooperate if they don't even believe you?'' Dharma said.

Scientists are still working to determine how bird flu is transmitted to and between humans. More than 200 people worldwide have contracted the deadly H5N1 strain of the virus since 2004. Most of the cases have resulted from contact with infected live or uncooked poultry, or with surfaces contaminated by infected birds.

Health investigators have concluded that the eight-person cluster in Sumatra began with Ginting's older sister, who fell ill in late April. They suspect she was infected with bird flu from live chickens sold in a market where she peddled oranges, limes and chili peppers, or from contaminated poultry droppings in manure used in her garden. She died and was buried before any samples were taken to confirm bird flu.

Several days after she became sick, the extended family had gathered in the village of Kubu Sembilang for a feast of roast pig and chicken curry to celebrate the annual harvest festival. That night, many of the relatives slept in the same small room with the sister, who had developed a serious cough. By the time she died, a sister, a brother, two sons, a niece and a nephew had become ill. Flu specialists said the final victim, her brother Dowes Ginting, in turn probably caught the virus from his infected son.

Health experts have concluded this was the first time the bird flu virus had been passed from one person to another and then on to a third person.

``None of us thought it was bird flu. We thought it was black magic,'' said Anestia Tarigan, the wife of the youngest Ginting brother, Jones, the only victim to survive. ``Everyone in the family was getting sick and no one else was. Someone had put a spell on our family. Black magic is very common in our place.''

Indonesian and WHO investigators discovered that many residents in Kubu Sembilang were unwilling to share information or give blood samples that could reveal how widely the virus was circulating. Many villagers believed that claims of bird flu were a lie. Some even threatened the investigators. When a team of officers first arrived from the provincial health department, they were warned by their local counterparts that it was too dangerous to enter the village.

``We chased them away,'' said Hendra Tarigan, whose wife, one of the Ginting siblings, died. ``Each time they came back, we gave them no information. We just told them to leave.''

Investigators were able to take samples from only two people in the village, including the local midwife, said Diana Ginting, chief of the district health department, who shares a common surname in the region.

Indonesian health officials working with an international team returned day after day to the village and made progress. They recruited 20 local volunteers to monitor fellow residents for fever and set up a temporary health post on the soccer field offering free medical care. The investigators methodically pieced together the chronology of the outbreak. They traced those who had contact with the victims and provided them with Tamiflu.

But many of those closest to the Gintings refused to take it.

As a medicine man treated Dowes Ginting, Indonesian and international health investigators finally tracked him down and urged his family to take him to a hospital. They demurred: He needed two more days of traditional treatment, they said. That night, he took a turn for the worse and died.

https://registration.mercurynews.co...om:80/mld/mercurynews/news/world/15425359.htm

:vik:
 

PCViking

Lutefisk Survivor
Yesterday's new was H5N1-LPAI found in Maryland...
http://www.timebomb2000.com/vb/showthread.php?t=209543&page=2, Posts 47 & 48.

Today's news...

Low-risk H5N1 bird flu found in Pennsylvania ducks

1 hour, 32 minutes ago

Mallard ducks in Pennsylvania have tested positive for a low-pathogenic strain of the H5N1 bird flu virus, the U.S. Agriculture and Interior departments said on Saturday, adding to cases detected recently in Maryland and Michigan.

A strain of the H5N1 avian influenza virus was found in wild ducks sampled August 28 in Crawford County in northwestern Pennsylvania.

"Testing has ruled out the possibility of this being the highly pathogenic H5N1 strain that has spread through birds in Asia, Europe and Africa," USDA and Interior said in a statement. "Test results thus far indicate this is low pathogenic avian influenza, which poses no risk to human health."

The government said it was conducting additional tests to determine, in part, if the ducks had H5N1 or two separate strains with one virus contributing H5 and the other N1. A second round of tests could take five to 10 more days to confirm whether it was the low-pathogenic H5N1 bird flu.

The virus also has been found during the last month in Michigan and on Friday in Maryland. The Maryland mallards did not appear sick so the samples, collected on August 2 as part of a research project, were not given high priority when sent to USDA labs for testing.

The U.S. departments of Agriculture and Interior are working with states to collect between 75,000 and 100,000 wild bird samples in addition to more than 50,000 environmental tests throughout the United States.

A low-pathogenic strain, which produces less disease and mortality in birds than does a high-pathogenic version, poses no threat to humans. It is common for mild and low pathogenic strains of bird flu to appear in the United States and other countries.

The latest H5N1 bird flu strain in Asia, Europe and Africa is known to have killed at least 141 people and forced hundreds of millions of birds to be destroyed.

(Additional reporting by Christopher Doering)

http://news.yahoo.com/s/nm/20060902/us_nm/birdflu_usa_dc

:vik:
 

JPD

Inactive
New cases of bird flu detected in domestic fowl in Egypt

http://www.iht.com/bin/print_ipub.php?file=/articles/ap/2006/09/04/africa/ME_GEN_Egypt_Bird_Flu.php

The Associated Press
MONDAY, SEPTEMBER 4, 2006

CAIRO, Egypt New cases of domestic fowl with bird flu were found in southern Egypt and Cairo last week, the Health Ministry said Monday, the first new cases to be reported in months.

Health Ministry official Amr Qandil said four people suspected with symptoms of bird flu in the southern province of Sohag were tested negative and discharged from hospital.

The new cases of birds with the lethal H5N1 strain of the virus were found in a village in Sohag, 345 kilometers (215 miles) south of Cairo, on Tuesday and in Cairo on Thursday. All the birds in the areas nearby were culled.

Six people have died of bird flu in Egypt since the disease broke out in the country in early March.

Qandil said the Health Ministry and the Agriculture Ministry have been making preparations to combat the disease in case it returned to the country with the new birds' migration season starting at the end of September.

Bird flu ravaged poultry farms in Asia in late 2003. It also jumped to humans killing at least 141 people worldwide. Most human deaths have been traced to contact with sick birds.

Experts fear the bird flu virus may mutate into a form that can easily spread among people, possibly sparking a pandemic.
 

JPD

Inactive
Indonesia imports 91 mln dosages bird flu vaccine from China

http://news.xinhuanet.com/english/2006-09/04/content_5047471.htm

JAKARTA, Sept. 4 (Xinhua) -- The Indonesian government has purchased 91 million dosages of bird flu vaccine from China and already received 31 million dosages, an official said Monday.

The remaining 60 million dosages are expected to arrive early this month, said Musni Suatmojo, director of veterinary with the Ministry of Agriculture.

"The vaccines will be distributed to areas hit by the disease or those potentially hit. We hope the distribution will be completed by December 2006," he was quoted by the national Antara news agency as saying.

Major poultry vaccination drives will be conducted this month and in February 2007, he said during a visit to the West Java capital of Bandung. Enditem
 

JPD

Inactive
Bird flu fear as 100 ducks die in Vietnam

http://news.scotsman.com/index.cfm?id=1305522006

MORE than 100 ducks have died suddenly in southern Vietnam in a suspected new bird flu outbreak.

Another 400 ducks were culled and samples were sent to the Ho Chi Minh City Regional Veterinary Centre for testing to determine whether the H5N1 strain of bird flu was responsible for the deaths discovered on Friday.

Vietnam had not reported any outbreaks in poultry this year until the virus was detected through random testing in a handful of poultry in southern Ben Tre province last month.
 

JPD

Inactive
Dual H5N1 Bird Flu Infections in North America

http://www.recombinomics.com/News/09030601/H5N1_Dual_NA.html

Recombinomics Commentary
September 3, 2006

It is possible that these birds were not infected with an H5N1 strain, but instead with two separate avian influenza viruses, one containing H5 and the other containing N1. The confirmatory testing underway at USDA's National Veterinary Services Laboratories will clarify whether one or more strains of the virus are present, the specific subtype, as well as confirm the pathogenicity.

The above comments raise the possibility of dual or multiple infections in the H5N1 positive mallards, which is a distinct possibility. However, the cloned H5N1 from a mute swan in Michigan was H5N1 and sequence data from mallards in Maryland and Pennsylvania indicate that the H5 positive samples in those states are similar to the H5N1 detected in Michigan. Thus, although the isolates from Maryland and Pennsylvania may be mixtures, both samples likely include H5N1.

The finding of the H5N1 serotypes in all three states is unexpected based on results from southern Canada in 2005. The Canadian tests found H5 in 218 birds, and the vast majority, 187, was in mallards. However, most of these isolates were not H5N1. Most of the H5 positives were in British Columbia, where H5N2 and H5N9 serotypes were identified. The second highest total was in Quebec, where H5N3 was found. The initial reports indicated H5N1 was only detected in Manitoba. Only three birds in Ontario were H5 positives, even though three of the collection sites were near the northern shores of Lake Erie.

However this year, the Michigan isolates were at the western end of Lake Erie and the Pennsylvania isolates were in Crawford County, near the southern shores of Lake Erie. This year Canada has not reported H5 in wild birds, but H5 was detected in a dead goose on a farm on Prince Edward Island. Three other geese also died after showing symptoms found in waterfowl infected with the high path Qinghai strain of H5N1 bird flu. The H5 test was a confirmatory PCR test, which not only identifies samples that produce a positive reaction, built also generate an insert that can be sized and sequenced. Although the insert was not sequenced, it was scanned for intensity and its size should distinguish between high and low path since the Qinghai strain of H5N1 has 4 additional amino acids at the HA cleavage site which would generate an insert that was 12 BP larger than low path H5N1.

The insert size could be used to identify mixtures of H5N1. The HA insert that covered the HA cleavage site would be 12 BP larger than low path. Similarly, the H1 from the Qinghai strain has a 20 amino acid deletion, which would generate an insert that would be 60 BP shorter, as seen in lane 3 of the linked elctrophoregram.

Last year the H5 detected in wild birds in Canada was frequently in a mixture of serotypes. Similarly, wild bird isolates collected by Ohio State University frequently had mixtures of two or more serotypes. However, detection of H5N1 in North America is rare. At Genbank there are only three North American isolates of H5N1 and the most recent was in 1986. More isolates are in the process of being sequenced and are listed below. However, none of these isolates are clearly H5N1 Maryland 851 has a mixture of H5 and H6 with N1), including mallards in Maryland in 2002, which were H5N2. The samples being sequenced extend through 2005 collections in Alaska, but none are H5.

The sudden increase in H5N1 in the United States is cause for concern. Since the low path is the same serotype as the high path in migratory birds, mixtures will be more difficult to detect. The H5 from the dead goose on Prince Edward Island was in low abundance which could be obscured by high levels of low path H5N1. Moreover, low path H5N1 can acquire mammalian sequences, as was seen in the H5N2 from British Columbia collected last year. Low path H5 and easily recombine with high path H5 because of extensive regions of identity in the H5 gene, as well as the other 7 gene segments.

Although the 2006 surveillance plan for Canada calls for increasing the numer of tested birds to over 12,000, the program has only released one sequence from the 208 postives birds from 2005. Moreover, there have been no reports from 2006, even though testing from the northern shores of Lake Erie would almost certainly detect H5N1 last month. Thus far the H5N1 positives in the United States are in the Atlantic Americas flyway, which links to the East Atlantic flyway, which coverns western Europe and Africa as well as Siberia, the source of many recent Qinghai H5N1 infections..

Release of the H5 low path sequences may offer clues as to why H5N1 has become the dominant H5 sequence detected In the United States and Canada in 2006.

Isolates by OSU which are being sequenced by TIGR and soon to be public at GenBank

A/mallard/Ohio/184/1986(H5N1)
A/mallard/Maryland/470/2002(H5N2)
A/mallard/Maryland/786/2002(H5N2)
A/mallard/Maryland/851/2002(H5,6N1)
A/mallard/Maryland/792/2002(H5N2)
A/mallard/Maryland/890/2002(H5N2)
A/mallard/Maryland/789/2002(H5N2)
A/mallard/Maryland/795/2002(H5N2)
A/mallard/Ohio/556/1987(H5N9)
A/mallard/Maryland/302/2001(H5N2)
A/mallard/Maryland/252/2001(H5N2)
A/mallard/Maryland/791/2002(H5N2)
 

JPD

Inactive
Mystery Swine Deaths in Eastern China

http://www.recombinomics.com/News/09040601/Mystery_Swine_China.html

Recombinomics Commentary
September 4, 2006

Since June 2006, a pig disease characterized by rising body temperature, redness of the skin, and rapid breathing has occurred in portions of Anhui, Jiangxi, Zhejiang, Hunan, Hubei, Jiangsu, and other provinces.

News obtained from the Hunan, Jiangxi, Fujian regions shows that this outbreak has caused large-scale pig herd deaths in parts of the region. In the area of Nanchang in Jiangxi alone, nearly one million pigs may have died

The above comments on a spreading fatal swine disease in China are alarming on several fronts. There has been little coverage in the press and no diagnosis for the widespread outbreak. The regions affected correspond to locations where the Fujian strain of H5N1 has been reported. H5N1 in swine has also been reported in Fujian province (see below).

Swine can host swine, avian, and human influenza. Swine are mixing vessels for influenza reassortment and recombination. In Canada, the level of reassortment and recombination in swine has increased in recent years.

Earlier reports to ProMed in 2005 suggested unreported H5N1 bird flu in Fujian, Jiangxi, and Jiangsu was common. The failure to report the large scale swine deaths in the same areas is cause for concern.

More details on the clinical symptoms and etiological agents would be useful.

A/swine/Anhui/2004(H5N1)
A/swine/Fujian/1/2003(H5N1)
A/swine/Fujian/F1/2001(H5N1)
A/swine/Guangdong/1/2003(H5N1)
A/swine/Guangdong/2/2003(H5N1)
A/swine/Guangdong/4/2003(H5N1)
A/swine/Guangdong/5/2003(H5N1)
A/swine/Shandong/2/03(H5N1)
 

PCViking

Lutefisk Survivor
Indonesia

Here's an :dot5: that we may be getting less "Bird Flu" news from Indonesia in the future.

Tuesday September 5, 2006

Indonesia to fight terrorism, bird flu
Agencies

Singapore, Sept 4: Trying to woo investors, Indonesian president Susilo Bambang Yudhoyono on Monday promised to step up efforts to combat corruption, terrorism, bird flu and other threats to the stability of Southeast Asia's largest country.

Addressing about 400 company executives and diplomats at a business conference in Singapore, Yudhoyono also said his government was committed to the process of democratization and to creating a more favourable climate for investment.

"With the successful reforms, Indonesia will be an easy, attractive and profitable place for businesses, local and foreign, to grow," Yudhoyono said in a luncheon speech at the Forbes Global CEO Conference. "I promise to do all I can to make it one of your best investment decisions."

Yudhoyono said his administration has been taking concrete measures to tackle an endemic corruption problem that has chased businesses away in the past.

"My government has now launched an anti-corruption campaign that is perhaps unprecedented in our nation's history. Our anti-corruption measures have spared no one from the arms of the law," he said.

Yudhoyono said his country would continue to intensify its fight against terrorism through direct operations as well as by tackling poverty.

He also said that Indonesia, the country worst hit by bird flu, has been taking steps to curb the virus's spread and prepare for the possibility of a flu pandemic, by vaccinating poultry and stockpiling flu medicines. He acknowledged, however, that more needed to be done.

To attract investment, he said, lawmakers were working to revise legislation and policies. He added that the government was "fully committed" to lowering corporate taxes while expanding the country's tax base.

"In our new draft bill, we plan to lower corporate tax from 30 per cent down to 25 per cent by 2010," Yudhoyono said. Yudhoyono, who took office in October 2004 as Indonesia's first directly elected president, was also to meet later on Monday with Singaporean Prime Minister Lee Hsien Loong, with whom he would discuss regional and bilateral issues.

http://www.centralchronicle.com/20060905/0509192.htm

:vik:
 

PCViking

Lutefisk Survivor
England

Avian flu research 'could be cut'
Vital research into avian flu, environmental pollution and food safety could be reduced to save money, government scientists have claimed.


The Department of Food and Rural Affairs (Defra) has to save £200m partly due to mistakes at the Rural Payments Agency, said Farming Today.

The union Prospect told the BBC Radio 4 programme its members could be forced out of work as a result of the cuts.

Defra said ministers were still working on the budget and would not speculate.

Target for cuts

Farming Today's Anna Hill said Defra's shortfall was due in part to "costly mistakes at the Rural Payments Agency (RPA), which failed to deliver a new subsidy system to farmers on time".

The agency had been criticised for late payments of the new subsidy, which gives farmers a single sum irrespective of how much food they produce.

Some 2,000 farmers were then overpaid by £20m this summer, for which Defra apologised.

Some cheques were stopped, while the agency said it would contact other farmers about recovering the money.

Defra has to save the money in the next six months and government scientists believe they could be the target for cuts.

Prospect told Farming Today public health could be affected if research was reduced.


The union is due to launch a campaign to highlight its concerns.

Defra said until the budget was finalised, it would be premature to speculate on its potential effects.

Story from BBC NEWS:
http://news.bbc.co.uk/go/pr/fr/-/2/hi/uk_news/5311134.stm

Published: 2006/09/04 02:10:07 GMT

:vik:
 

JPD

Inactive
Indonesian govt to build bird flu handling center in Tangerang

http://www.antara.co.id/en/seenws/?id=19486

Serang, Banten (ANTARA News) - The Indonesian government will set up a bird flu (Avian Influenza/AI) handling centre here in the near future to overcome bird flu cases, head of the local health office Dr Djadja Buddy Rahardja said on Tuesday.

"The compound of the centre will be designed based on international standards with funding from some donor countries including Japan, Hong Kong and Taiwan and some donor organizations including the United Nations Children`s Fund (UNICEF) and the World Health Organization (WHO)," he said.

He said the centre would be the venue for formulating a strategy to handle bird flu, he added.

"The centre will have many kinds of equipment, the medicines needed to fight the bird flu virus and a training venue for paramedics on ways to treat patients," he said.

Indonesia had its first human bird flu case when a father and his two daughters died here last year. Indonesia also had the biggest bird flu cluster case. At least 10 provinces have been declared affected by the disease.

Asked when the project would be commenced, he said it would be started as soon as the donor countries and organizations had sent the needed equipment and other materials.

"A memorandum of understanding on the project was signed by President Susilo Bambang Yudhoyono with the related department some time ago and it is now in the realization phase," he added.

On the number of people infected with the virus, quoting latest data from the health ministry, he said 47 out of 62 patients who had tasted positive for the virus had died.

In Banten, he added, nine out of 14 suspected bird flu patients had died.
 

JPD

Inactive
China Acknowledges Not Giving WHO Bird Flu Samples

http://www.cattlenetwork.com/content.asp?contentid=65509

BEIJING (Dow Jones)--China acknowledged it hasn't given the World Health Organization any bird flu samples taken from poultry since 2004, blaming the long delay on talks over the protocol for how to hand over the virus to international labs.

"When viral strains cross international borders, special protocols are needed and we are working to finish them," vice director of the Ministry of Agriculture's veterinary department Li Jinxiang said Tuesday. International scientists say they need the bird flu samples from poultry to study the development of the H5N1 virus that causes avian flu and to help make drugs and vaccines to fight the disease.

They're also crucial to tracking any changes that could make bird flu easy to catch from human-to-human contact, a transformation that could turn it into a pandemic capable of killing millions.

Already, more than 100 people have been killed since 2003, most, if not all, from contact with infected birds. In March, China promised to hand over poultry samples to the World Health Organization.

China has shared strains of the bird flu virus found in humans, but hasn't shared any samples taken from animals since 2004, when it provided samples from five animals. "There are no real logistical reasons why the (poultry) virus can't be shared," said Julie Hall, coordinator for the WHO Epidemic Alert and Response Team in Beijing.

"The Ministry of Health regularly shares (the human) H5N1 with us. The logistics are there to transport these safely and quickly." Li said that though the Ministry of Agriculture hasn't shared samples from poultry, it has shared the results of laboratory tests, including genetic information, with international agencies. Critics say that's not enough.

They accuse the Ministry of Agriculture of dragging its feet in order to protect Chinese scientists who are working on coming up with a vaccine or cure and could lose their competitive edge if that information was made widely available.

The WHO is under fire by some scientists who say it isn't being transparent enough with information about the virus. Advocates for opening up the WHO's research database, which is now tightly restricted, say that lack of information is slowing the search for a cure.

Li said China had vaccinated nearly 5 billion poultry in the first six months of this year, and that authorities were monitoring for any signs of resistance to vaccines. He said there were some problems reaching more remote parts of China for vaccinations, as cross contamination with wild birds continues to cause outbreaks.
 

PCViking

Lutefisk Survivor
New bird flu outbreak hits Cambodian ducks

2 hours, 18 minutes ago


A new bird flu outbreak has been found in ducks in eastern Cambodia where the virus re-emerged last month, officials said on Tuesday.

Tests confirmed the deadly H5N1 virus in live and dead ducks in the Bateay district of the eastern province of Kampong Cham where 700 birds died last week, they said.

"We sent our vets to cull the rest of the live ducks after the result was confirmed on Saturday," senior agriculture official Yim Voeunthan told Reuters.

The virus could have spread from a nearby village where a bird flu outbreak killed nearly 2,000 ducks last month, said Ku Chanthan, a veterinarian in Kampong Cham.

In early August, the virus was also found among 1,300 ducks that died in the province of Prey Veng, 70 km (45 miles) southeast of Phnom Penh.

Authorities suspected surviving infected ducks from Prey Veng may have been smuggled to Kampong Cham, where surveillance efforts against the virus have been stepped up.

"We are worried that more bird flu will be found in ducks because our survey experience showed that up to 15 percent of live ducks carried the virus," Yim Voeunthan said.

The H5N1 bird flu virus has killed more than 140 people worldwide, including six in Cambodia, according to the World Health Organization.

The virus has not yet shown the ability to mutate into a form that could pass easily between humans and cause a pandemic that might kill millions of people.

But experts fear it might, especially in a poor country such as Cambodia, which is recovering from 30 years of civil war and where health surveillance systems are limited.

http://news.yahoo.com/s/nm/20060905/hl_nm/birdflu_cambodia_dc

:vik:
 

JPD

Inactive
Bird flu kills nearly 600 chickens in Indonesia's West Java

http://english.peopledaily.com.cn/200609/06/eng20060906_299944.html

Indonesian authorities have warned of a major bird flu outbreak in the West Java town of Kuningan after 596 chickens died of the disease in August, an official said Tuesday.

Local officials said bird flu attacks were found in two districts, namely Cigugur and Darma.

"The 596 chickens died of bird flu based on rapid tests (at the scene) and laboratory tests," said Nana Adnan, head of the West Java veterinary office.

Following the findings, authorities plan to cull 3,000 chickens in the affected areas, he was quoted by the national Antara news agency as saying.

Local officials have culled some 5,000 chickens in nearby Garut regency after one person died of bird flu based on local tests.

Indonesia now has the world's highest bird flu death toll of 47 out of 62 sufferers since the first human case was confirmed two years ago.
 

JPD

Inactive
H5N1 Garut Cluster Sequences Similar to Western Java

http://www.recombinomics.com/News/09050601/H5N1_Garut_Sequence.html

Recombinomics Commentary
September 5, 2006

Sequences from three recent isolates from Indonesia, A/Indonesia/CDC739/2006(H5N1), A/Indonesia/CDC742/2006(H5N1), A/Indonesia/CDC759/2006(H5N1) were made public today. The HA of all three have the common cleavage site of RESRRKKR. Two of the HA, sequences are similar to A/Indonesia/CDC/669/2006(H5N1).

One of these sequences appears to be from the second confirmed fatality (35F) of the Garut cluster. Its similarity to recent isolates from the Jakarta / West Java area indicates that the H5N1 in human cases continue to evolve and spread into new areas.

Although there were only three confirmed cases in the Garut cluster, several relatives of the positives died earlier with bird flu symptoms. However, samples were not collected from these contacts, highlighting surveillance failures. This poor surveillance also eliminates clusters, because index cases are not tested. Similarly, the negatives in contacts with symptoms may be false because of the use of a Tamiflu blanket.

Thus, the similarity in the H5N1 in Garut with other human cases on Java suggested that human cases and clusters are far more widespread than indicated by the confirmed cases.

These recent sequences were easily distinguished from the only avian isolate to date with the RESRRKKR cleavage site. Sequence data from birds linked to recent outbreaks in Indonesia would be useful.
 

JPD

Inactive
Spread of bird flu virus in N. Sumatra still worrying

http://www.antara.co.id/en/seenws/?id=19576

Medan, North Sumatra (ANTARA News) - The spread of the bird flu (Avian Influenza/AI) virus in North Sumatra is still worrying despite the cull of some 73,096 poultry in the province recently, a provincial government official said.

The poultry cull was intended to break the chain of the HN51 virus` transmition, a spokesman of the North Sumatra Administration said here on Wednesday.

Of the total 73,096 culled poultry, some 37,458 were in Karo District, 20,012 in Simalungun, 14,727 in Dairi and 899 in Deli Serdang District.

For every chicken or bird culled, the government provided compensation worth Rp12,500 each.

Bird flu cases have occurred in 16 districts out of the total 25 districts in North Sumatra up to August 2006.

Among the affected districts are Deli Serdang, Binjai, Dairi, Medan, Tebing Tinggi, Langkat, Samosir, Serdang Bedagai, Simalungun, Tapanuli Selatan, Tapanuli Utara, Toba Samosir, Mandailing Natal, Humbang Hasundutan, and Kabupaten Karo.

The bird flu virus infection has badly affected the poultry business in the province.

A total of 10 nations have detected outbreaks of the animal disease in humans. Indonesia had reported some 67 cases, the highest figure in the world. Indonesia`s Ministry of Health recently reported the country`s 43rd death resulting from infection with the H5N1 avian influenza virus.

Like the vast majority of other human cases detected throughout the region, contact with ailing chickens around the household is the apparent means by which the latest human case occurred.

Human cases appeared for the first time in Indonesia in 2005. (
 

PCViking

Lutefisk Survivor
Flu Rocundup: Bird outbreaks in 4 countries
By Kate Walker Sep 6, 2006, 18:34 GMT

LONDON, England (UPI) -- Avian-influenza outbreaks in birds have surfaced in four countries in recent days, with Egypt, Indonesia, Cambodia and Vietnam all reporting incidences of H5N1 infection.

In its first reported infections in two months, Egyptian officials announced that avian flu had been found in four birds, all part of domestic flocks. Three of the cases were discovered in Cairo, while the fourth was found in a small village near Sohag, in the south of the country.

The infections were detected during random tests on Egyptian birds conducted as a bird-flu control measure.

Hassan el-Bushra, regional adviser for communicable diseases surveillance at the World Health Organization, said of the discoveries: 'It is significant. It tells us that the virus is still circulating.'

It is hoped that these recent infections will not spark a wider outbreak of the sort seen earlier this year, when Egypt became the country to record the highest number of human infections -- 14, and six deaths -- outside of Asia.

Since the initial emergence of bird flu in Egypt in February this year, the Agriculture Ministry has been at work inoculating the country`s poultry flocks. The majority of commercial flocks have already been vaccinated, and the Agriculture Ministry says that approximately 20 percent of backyard flocks have also been inoculated. The vaccination program should prevent this latest outbreak from spreading, ministry officials said.

Indonesia`s West Java province, the site of a number of human infections this year, has reported an outbreak of avian flu in the town of Kuningan, where 596 chickens died at the end of August.

The presence of avian influenza was confirmed Tuesday.

Nana Adnan, head of the West Java veterinary office, said: 'The 596 chickens died of bird flu based on rapid tests (at the scene) and laboratory tests.'

Following the news of the outbreak, Indonesian officials announced that they were to begin culling 3,000 chickens in the region in an attempt to prevent the outbreak from spreading.

Cambodian officials Tuesday announced that there had been an outbreak of avian flu in ducks in the east of the country.

Seven hundred birds in the Bateay district of the eastern province of Kampong Cham died last week, prompting the Agriculture Ministry to conduct tests on live and dead birds. The test results, which were returned Saturday, confirmed the presence of H5N1 in both live and dead ducks in the area.

According to senior Cambodian agricultural officials, the ministry responded to the news of the confirmation by beginning the widespread culling of all live ducks in the vicinity.

In August, a village near to the site of the current outbreak saw a wave of avian-influenza infections in ducks in which 2,000 died. It is believed that these latest cases may have stemmed from that outbreak.

The sudden deaths of more than 100 Vietnamese ducks have sparked fears of yet another avian-influenza outbreak in the badly hit country.

In Vietnam`s second outbreak this year, a wave of ducks in the south of the country died of what is so far only suspected to be avian influenza. Samples from the dead birds have been sent to the Ho Chi Minh City Regional Veterinary Centre for testing; there is as yet no news of when the results are to be expected.

When news of the possible outbreak emerged, Vietnamese veterinary officials culled 400 birds in the area.

In more positive bird-flu news, Myanmar has declared itself to be free of avian influenza.

According to Myanmar`s state-run New Light of Myanmar newspaper, a three-month avian-influenza detection program turned up no new cases. As a result, the country has officially declared itself to be free of the disease.

In late April livestock officials began working with a team of international avian-flu experts to determine whether avian flu had taken hold in the country. The three-month program established that bird flu had not spread beyond Mandalay and Sagaing, where bird flu was first detected in March. Additionally, there were no further signs of infection in the two central provinces.

Following the completion of the three-month program, Myanmar`s Livestock Ministry was able to 'declare Myanmar as a nation free from bird flu,' New Light of Myanmar reported.

Avian flu first emerged in Myanmar`s quails and chickens earlier this year. The country has seen no human infections.

http://news.monstersandcritics.com/...hp/Flu_Rocundup_Bird_outbreaks_in_4_countries

:vik:
 

JPD

Inactive
Indonesia

Teenager dies of bird flu raising toll to 47

http://www.thejakartapost.com/detaillgen.asp?fileid=20060907164650&irec=1

JAKARTA (AP): A teenager died of bird flu in eastern Indonesia, raising the country's human toll from the disease to 47, the health minister said Thursday, citing laboratory test results.

The 14-year-old boy from South Sulawesi's capital Makassar appears to have been in contact with infected poultry, said Siti Fadilah Supari, adding that authorities killed chickens found near the victim's home.

Lab tests for the teen came back late Wednesday, she said. The H5N1 virus has killed 142 people worldwide since ravaging poultry stocks across Asia in 2003, hitting Indonesia the hardest.

Most human cases have been traced to contact with infected birds, but experts fear the virus - which remains hard for people to catch - will mutate into a form that spreads easily among people, potentially sparking a pandemic that could kill millions.

Indonesia has come under fire for doing too little to stamp out the disease, which is endemic among some 500 million individually owned, or 'backyard,' chickens. Slaughtering often isn't carried out following outbreaks, vaccination is spotty andsurveillance is weak.

The government says it lacks the needed funds and, at the same time, many villagers deny their birds have the virus, even in areas where chickens are dropping dead and where human cases have occurred.Siti called on the public to "immediately inform officials if they noticed sudden deaths in poultry."

The Agriculture Ministry, meanwhile, announced plans this week to vaccinate some 60 million chickens against bird flu ahead of the coming rainy season, when experts fear the virus might spread more easily. (**)
 

JPD

Inactive
Vietnam

Localities urged to conduct second bird flu vaccination

http://vietnamnews.vnagency.com.vn/showarticle.php?num=01HEA070906

(07-09-2006)

Ha Noi — The Ministry of Public Health yesterday asked healthcare services and Pasteur Institutes nationwide to cooperate with the Ministry of Agriculture and Rural Development to strengthen the fight against avian influenza and avian influenza infection in humans.

Deputy Public Health Minister Trinh Quan Huan said that as avian influenza and influenza A infection in humans is developing and becoming more complex in regional countries, and an epidemic is becoming more likely in Viet Nam.

At present, although an epidemic has not yet broken out, blood specimens from ducks in Tan Trieu market in Ha Noi’s outlying district of Thanh Tri and in some households in the Cuu Long (Mekong) Delta province of Ben Tre have tested positive to H5.

Nguyen Tran Hien, Director of the National Institute of Hygiene and Epidemiology, said that the Prime Minister had ordered that his Institute receive aid of nearly US$1 million from the US Department of Health and Human Services to implement national-level scientific research on developing an effective vaccine against H5N1 from monkey’s kidney cells.

The research has been submitted to the Scientific Council of the Ministry of Science and Technology for consideration. It will then be submitted to the Scientific Council of the Ministry of Public Health for final approval, he said.

Minister of Agriculture and Rural Development Cao Duc Phat on Tuesday urged the Animal Health Department and domestic livestock breeding sector to carry out a second bird flu vaccination on poultry this year.

Speaking at the meeting held by the Steering Committee for Control of Bird Flu and Foot and Mouth Disease, Phat wanted localities to strengthen supervision, take samples and keep a watch on trade and slaughtering of poultry.

As for foot and mouth disease, he asked localities to closely supervise transport and slaughter of animals infected with the disease and report the same to the ministry. — VNS
 

JPD

Inactive
University of Michigan launches new website on 1918 flu pandemic

http://www.webwire.com/ViewPressRel.asp?aId=19760

http://www.med.umich.edu/medschool/chm/influenza/index.htm

University of Michigan
9/6/2006 1:14:24 PM

Digital archives give researchers access to primary source materials

September 6, 2006 - ANN ARBOR, MI – Examining how communities in the United States coped with the 1918 flu pandemic could help today’s public health planners in their preparations for the next flu pandemic. The Center for the History of Medicine at the University of Michigan Medical School has unveiled a website of primary source materials covering the infamous 1918-1920 influenza pandemic. Called the "1918-1920 Influenza Epidemic Escape Community Digital Document Archive,” the site was created with today’s researchers in mind.

Howard Markel, MD, Phd“The website is the result of a project funded by the federal Defense Threat Reduction Agency to identify and research a very important group of American communities. These are called escape communities and they experienced extremely low morbidity and mortality rates during the 1918-1920 influenza epidemic,” says Howard Markel, M.D., Ph.D., George E. Wantz professor in history of medicine and the center’s director.

Researchers at the center identified seven of these types of communities, gathering several thousand pages of primary and secondary source materials from a range of public and private archives, special collections, libraries, and other institutions. Using these materials, they composed a report detailing how the escape communities met the challenges of epidemic influenza.

“We believe these documents represent the definitive collection of primary source materials on the 1918-1920 influenza epidemic escape communities. In the interest of scholarly interaction and the sharing of knowledge, we have now made digitized copies of these sources freely available to the public through the new website,” says Markel.

All the original documents are on the site and are freely available to the public for research or educational purposes.

The website is organized around each of the seven escape communities and provides abridged versions of the community case studies included in the longer report. Researchers can view or download digital copies of any and all of the almost 2,000 pages of primary source documents that were collected and reviewed as part of the study.

A copy of the entire report, “A Historical Assessment of Nonpharmaceutical Disease Containment Strategies Employed by Selected U.S. Communities During the Second Wave of the 1918-1920 Influenza Pandemic,” is available on the archive website.

The archive can be accessed at: www.med.umich.edu/medschool/chm/influenza/index.htm

Markel’s collaborators on the project were Alexandra Stern, Ph.D., associate director, Center for the History of Medicine; J. Alexander Navarro, Ph.D., senior researcher, Center for the History of Medicine; and Joseph Michalsen, research associate, Center for the History of Medicine.
 

PCViking

Lutefisk Survivor
Delmarva

Bird flu strain in Md.
But virus found on Shore poses no human risk, scientists say

By Ted Shelsby and Justin Fenton
Originally published September 7, 2006

Avian flu has been detected in mallard ducks on a farm on the Eastern Shore, though officials caution that the low-pathogenic strain poses no risk to humans and is not the type that has been blamed for more than 140 deaths around the world.

Experts said the presence of the virus likely would not affect the $1.5 billion Delmarva poultry industry. Samples taken from chicken houses in the vicinity of where the ducks were found have tested negative for the virus, and though it is not known if the strain could infect chickens, such a scenario remains unlikely, they said.

It is the third case of avian flu infections detected in the U.S. since heightened testing began in April. Birds have tested positive in Michigan and Pennsylvania in recent weeks as a result of increased monitoring.

In the Maryland case, scientists detected the strain last week in nine fecal samples collected in early August from mallards at a Queen Anne's County farm. The samples were not immediately tested because the birds appeared healthy.


Though a strain of the avian flu, which in its high-pathogenic form is known as Asian H5N1, the recent findings were not the deadly version, said Guy Hohenhaus, the state veterinarian and chief of animal health for the Maryland Department of Agriculture.

"There is no evidence that this represents a human health problem," Hohenhaus said. "It's a run-of-the-mill duck problem with no human health implications."

Richard D. Slemons, a researcher with the Ohio State University team that collected the Maryland samples, said the virus attacks ducks in a digestive form but is a respiratory disease in domestic poultry. Only if the virus were able to circulate long enough among birds could it mutate to the higher strain - an unlikely event with stringent monitoring standards.

"These viruses go across the species barrier to domestic birds with great hesitancy," Slemons said. "Wild birds obviously are a reservoir for the type-A influenza virus, but it's a very different virus, and not as simple as it seems at first blush."

Poultry is the largest sector of agriculture in Maryland, which has about 1,200 chicken farms. Sales throughout Delmarva totaled $1.5 billion last year.

Maryland began strengthening its poultry regulations this year to guard against an outbreak of diseases such as avian flu to permit officials to rapidly respond to potential problems. The rules require the registration of all chicken flocks, along with pet birds including parakeets, canaries and parrots if there are four or more in a household.

An outbreak of avian flu in 2004 prompted the destruction of more than 300,000 chickens in the Delmarva region.

"Commercial poultry operations are designed to prevent exposure to other birds that may carry diseases," said Julie DeYoung, a spokeswoman for Perdue Farms in Salisbury. "This is further evidence of that monitoring and surveillance."

Fearing that the avian flu virus could mutate and become transmissible among humans and trigger a pandemic, Congress approved $29 million for additional monitoring last month. Samples from 75,000 to 100,000 wild birds a year are expected to be collected nationwide.

Sherrill Davison, an associate professor of avian medicine and pathology and director of the Laboratory of Avian Medicine and Pathology at the University of Pennsylvania School of Veterinary Medicine, said that mallard ducks are among the species most commonly found to have the avian influenza virus present in their system. But it is not the virulent strain has killed millions of birds and more than 140 people in Asia and the Middle East.

In August, a wild pair of mute swans nesting near Lake Erie became the first wildlife in this country to test positive for the non-lethal strain since 1986. On Saturday, federal agricultural officials said they found the strain in wild ducks in Crawford County, Pa.

Slemons, however, said he has personally encountered more than 400 birds with the lower-strain virus. "It's been detected only a few times, but we haven't looked very hard until now,"
he said.

On the Eastern Shore, fecal samples were collected Aug. 2 from resident wild ducks as part of a research project conducted by Ohio State University. Because there was no sign of illness in the birds, the samples were not given a high priority for testing and were received at an Iowa lab Aug. 24. A week later, tests came back positive for an H5N1 subtype.

Hohenhaus would not elaborate on where the Maryland waterfowl were located. He said the birds were on private property and the landowner, "out of civic duty," has allowed the state to test the birds periodically.

Some farms keep ducks as part of agriculture tourism that allows school groups to visit farms to see animals and learn about farming, he said. Others keep ducks to accommodate hunters.


John L. Chew Jr., Queen Anne's County's director of emergency management, said the county's large populations of poultry and migratory waterfowl magnify the risk of an outbreak. "Our risk is substantial given that environment," he said.

State Agriculture Secretary Lewis R. Riley said that properly cooked poultry meat remains safe to eat. He encouraged hunters, poultry growers, and bird owners to maintain a high level of biosecurity on farms and in their everyday handling of birds.

Recommendations included restricted access to poultry farms, wearing protective clothing and shoes in poultry houses, and keeping commercial poultry indoors and away from migratory birds.

http://www.baltimoresun.com/news/health/bal-md.avian07sep07,0,3839056.story?track=rss

:vik:
 

Bill P

Inactive
From PCVIking's last post:

Only if the virus were able to circulate long enough among birds could it mutate to the higher strain - an unlikely event with stringent monitoring standards.


Is this an accurate statement?

This is first I have read that LPAI can mutate to lethal HPAI over time by continued infection of a given bird population.

I was under the impression (wrongly?) that the LPAI lacked certain genetic markers (as detailed by Dr Niman and others) AND that the only way for the H5N1 to acquire these if from recombinantion or reassortment with an infected HPAI bird.

If the quoted statement is true, I dont see that stringent monitoring makes this an unlikely event - we are talking migratory birds. Do they imply they can monitor the health of all birds, everywhere. I doubt it.

I read this that the H5N1 is now in the USA and can become the Highly Pathological type over time. If so, the horse is not only out of the starting gate; but he is approaching the home stretch.
 

Bill P

Inactive
University of Michigan launches new website on 1918 flu pandemic

University of Michigan
9/6/2006 1:14:24 PM

WebWire Related Industries
• Education
• Health Care/Hospitals
• Higher Education
• Infectious Disease Control
• Multimedia/Online/Internet
Digital archives give researchers access to primary source materials


September 6, 2006 - ANN ARBOR, MI – Examining how communities in the United States coped with the 1918 flu pandemic could help today’s public health planners in their preparations for the next flu pandemic. The Center for the History of Medicine at the University of Michigan Medical School has unveiled a website of primary source materials covering the infamous 1918-1920 influenza pandemic. Called the "1918-1920 Influenza Epidemic Escape Community Digital Document Archive,” the site was created with today’s researchers in mind.


Howard Markel, MD, Phd“The website is the result of a project funded by the federal Defense Threat Reduction Agency to identify and research a very important group of American communities. These are called escape communities and they experienced extremely low morbidity and mortality rates during the 1918-1920 influenza epidemic,” says Howard Markel, M.D., Ph.D., George E. Wantz professor in history of medicine and the center’s director.


Researchers at the center identified seven of these types of communities, gathering several thousand pages of primary and secondary source materials from a range of public and private archives, special collections, libraries, and other institutions. Using these materials, they composed a report detailing how the escape communities met the challenges of epidemic influenza.


“We believe these documents represent the definitive collection of primary source materials on the 1918-1920 influenza epidemic escape communities. In the interest of scholarly interaction and the sharing of knowledge, we have now made digitized copies of these sources freely available to the public through the new website,” says Markel.


All the original documents are on the site and are freely available to the public for research or educational purposes.


The website is organized around each of the seven escape communities and provides abridged versions of the community case studies included in the longer report. Researchers can view or download digital copies of any and all of the almost 2,000 pages of primary source documents that were collected and reviewed as part of the study.


A copy of the entire report, “A Historical Assessment of Nonpharmaceutical Disease Containment Strategies Employed by Selected U.S. Communities During the Second Wave of the 1918-1920 Influenza Pandemic,” is available on the archive website.


The archive can be accessed at:

www.med.umich.edu/medschool/chm/influenza/index.htm


Markel’s collaborators on the project were Alexandra Stern, Ph.D., associate director, Center for the History of Medicine; J. Alexander Navarro, Ph.D., senior researcher, Center for the History of Medicine; and Joseph Michalsen, research associate, Center for the History of Medicine.


Written by Mary Beth Reilly


Related Links

University of Michigan
www.umich.edu


www.med.umich.edu/medschool/chm/influenza/index.htm

Contact Information
Mary Beth Reilly

University of Michigan
(734) 764-2220
reillymb@umich.edu
 

Fuzzychick

Membership Revoked
The season is drawing near or from what I've read here, it's started...the detection of any bird in the U.S. should be a wake up call to the CDC and WHO, but they haven't said jack on their sites...time to watch and wait, but the occasion of someone stepping up to the plate to admit the imposing threat is mute, remember to keep your powdermilk and tunafish under your beds.:kk2:
 

JPD

Inactive
Cairo confirms fresh cases of bird flu

http://www.iol.co.za/index.php?set_id=14&click_id=143&art_id=qw1157665501325B221

Cairo - Egypt uncovered new cases of bird flu in domestic fowl, the health ministry said on Thursday.

Birds tested positive for the lethal H5N1 strain in locations in the southern province of Sohag and the Mediterranean coastal province of Damietta, the ministry said.

"Teams were culling the infected birds in both locations," it said in a statement on the state news agency MENA.

The ministry on Tuesday announced Egypt's first discovery of infected birds in months, raising concerns over a return of the virus with the start of the migration season.

Six people died of bird flu in Egypt since the disease broke out in the country in early March, sparking a massive cull of poultry across the country.

Bird flu, or H5N1, ravaged poultry farms in Asia in late 2003. It also jumped to humans killing at least 141 people worldwide. Most human deaths have been traced to contact with sick birds. - Sapa-AP
 

JPD

Inactive
Cambodian study suggests mild H5N1 cases are rare

http://www.cidrap.umn.edu/cidrap/content/influenza/avianflu/news/sep0706cambodia.html

Sep 7, 2006 (CIDRAP News) – Researchers who tested 351 Cambodian villagers after they had extensive contact with avian influenza–infected poultry in 2005 found that none had antibodies to the H5N1 virus, suggesting that it doesn't easily spread to humans and that mild cases are rare.

"Our findings suggest that asymptomatic and mild H5N1 virus infections had not occurred in the population we investigated," says the report, published by Emerging Infectious Diseases. The study was done by an international team of scientists, with Sirenda Vong of the Institute Pasteur in Phnom Penh, Cambodia, as first author. Preliminary results were reported at a conference last March.

Some experts have speculated that the current case-fatality rate for H5N1 avian flu, about 59%, could be inaccurate because mild or asymptomatic cases have gone undetected. Few such cases have been found in the limited number of studies on the topic so far.

The village involved in the new study was the home of a 28-year-old man who had Cambodia's second confirmed H5N1 case. The man, from Banteay Meas district in southeastern Cambodia, died in March 2005.

After his death, Cambodian health officials launched an investigation to find additional cases and identify how the patient was exposed. The researchers said the rural village setting allowed them to study the epidemiologic features of the H5N1 virus in poultry and humans. Focusing on a 1-kilometer radius around the patient's house, the researchers conducted a retrospective survey of poultry deaths immediately after the patient's H5N1 infection was confirmed. Two months later they conducted a serologic investigation of members of 93 households.

Villagers were questioned about recent illnesses in their chickens, and researchers collected samples from sick, dead, and randomly selected healthy chickens. The investigators also interviewed villagers about their exposure to animals and the environment during the previous 12 months and took blood specimens from each of them.

The poultry survey revealed that 42 households were likely to have had an outbreak of H5N1 in poultry, reflecting an overall attack rate of 27% among households with chickens. Only two households reported the simultaneous deaths of ducks, and raising ducks with chickens was not associated with deaths in chickens.

Cloacal specimens from two sick chickens tested positive for the H5N1 virus. The owner of the chickens reported that the man who died of avian flu had spent daylight hours in his compound.

In the serologic survey, investigators found that substantial numbers of villagers had had regular, close contact with poultry or pigs over the previous 12 months. Despite this, none of the villagers reported having had a febrile or respiratory illness during the same period, and none of the residents had antibodies that suggested they had been infected with the H5N1 virus.

The researchers said their finding of little H5N1 transmission between infected poultry and humans is consistent with recent studies among healthcare workers and household contacts of patients. The findings also suggest that none of the villages had an asymptomatic or mild H5N1 infection, they added.

The authors said they couldn't explain why only one person became infected when so many others had similar exposure and did not have evidence of infection. "H5N1 virus transmission in humans may be rare because it only occurs in exposed persons with unique host susceptibilities and a predisposition to an abnormal inflammatory response that results in severe and fatal outcomes, rather than causing a broad spectrum of illness with mild disease and subclinical infections," the article states.

The scientists found that some poultry-keeping practices appeared to affect a flock's chance of contracting the H5N1 virus. Handling poultry, cleaning their stalls and cages, and collecting feathers seemed to reduce infections, while purchasing live poultry seemed to increase the risk.

Though the H5N1 virus does not spread easily to humans, the researchers cautioned that that could change as the virus continues to circulate and evolve, and they called for routine, extensive investigations of all H5N1 outbreaks among humans and animals.

Vong S, Coghlan B, Mardy S, et al. Low frequency of poultry-to-human H5N1 virus transmission, southern Cambodia, 2005. Emerg Infect Dis 2006;12(10) [Full text]

See also:

Mar 27, 2006, CIDRAP News story "Mild H5N1 cases weren't missed in Cambodian outbreak"

Mar 29, 2005, WHO statement on second Cambodian case
http://www.who.int/csr/don/2005_03_29b/en/index.html

Sep 29, 2005, New England Journal of Medicine article "Avian influenza A(H5N1) infection in humans" (see table 2 for results of serologic testing of patient contacts) [Full text]
 

JPD

Inactive
Indonesia

Spread of bird flu virus in N Sumatra still worrying

http://www.antara.co.id/en/seenws/?id=19692

Medan, North Sumatra, (ANTARA News) - The spread of the bird flu (avian influenza) virus in North Sumatra is still worrying despite the cull of some 73,096 poultry in the province recently, a provincial government official said.

The poultry cull was intended to break the chain of the HN51 virus` transmition, a spokesman of the North Sumatra Administration said here on Wednesday.

Of the total 73,096 culled poultry, some 37,458 were in Karo District, 20,012 in Simalungun, 14,727 in Dairi and 899 in Deli Serdang District.

For every chicken or bird culled, the government provided compensation worth Rp12,500 each.

Bird flu cases have occurred in 16 districts out of the total 25 districts in North Sumatra up to August 2006.

Among the affected districts are Deli Serdang, Binjai, Dairi, Medan, Tebing Tinggi, Langkat, Samosir, Serdang Bedagai, Simalungun, Tapanuli Selatan, Tapanuli Utara, Toba Samosir, Mandailing Natal, Humbang Hasundutan, and Kabupaten Karo.

The bird flu virus infection has badly affected the poultry business in the province.

A total of 10 nations have detected outbreaks of the animal disease in humans. Indonesia had reported some 67 cases, the highest figure in the world. Indonesia`s Ministry of Health recently reported the country`s 43rd death resulting from infection with the H5N1 avian influenza virus.

Like the vast majority of other human cases detected throughout the region, contact with ailing chickens around the household is the apparent means by which the latest human case occurred.

Human cases appeared for the first time in Indonesia in 2005.(*)
 

JPD

Inactive
Indonesia

S. Sulawesi site of 48th bird flu death

http://www.thejakartapost.com/detailheadlines.asp?fileid=20060908.A07&irec=6

The Jakarta Post, Jakarta

The government confirmed Thursday another person had died of bird flu, as the nation hardest hit by H5N1 continues to battle a disease that is feared could one day spark a global pandemic.

The 48th fatality from the virus was a woman from South Sulawesi province who died in June, said Health Minister Siti Fadilah Supari, adding that infected birds were found dead in the same area.

"This we know from the results of the (tests by the) Health Ministry's Research and Development Board last night (Wednesday)," Siti said as quoted by AFP.

"We did not send (the samples) to the WHO (World Health Organization) because our positive results are usually positive results at the WHO."

Siti announced in August that local testing facilities in Jakarta were considered adequate to confirm H5N1.

Sari P. Setiogi, the WHO spokeswoman in Indonesia, said that under a new arrangement Jakarta could confirm infections after two local tests showed the person to have contracted H5N1.

Siti gave no further details other than that the latest bird flu case had been first discovered on June 24.

Runizar Roesin from the National Bird Flu Center said that the long time between the discovery of the case and the result of the testing was because the samples were not specifically taken from the patient on suspicion of bird flu.

The woman had been reported as suffering from a high fever by a local doctor in June and a Health Ministry team took her sample.

It was later forwarded to the Health Ministry's laboratory for bird flu tests.

Siti said that they would soon carry out poultry culls in the area where the case was found. Officials said the local health office was trying to retrace where the woman came from.

While there have been no confirmed cases of human-to-human transmission, doctors warn the chance of a mutation that would allow it to do so is heightened as more humans catch it from infected birds.

Meanwhile, in South Minahasa regency, North Sulawesi, results of laboratory tests were positive for H5N1 Thursday in hundreds of chickens which died in Rumoong Bawah village in West Amurang district 10 days earlier.

Boy Rompas, spokesman of the North Sulawesi provincial administration, said the tests were conducted at the Balai Besar Livestock Laboratory in Maros, Makassar, South Sulawesi.

Data at Amurang Livestock Office showed that in the period June-August this year, at least 572 chickens died in the village.

The dead chickens were owned by 28 families, while 1,619 others that tested positive were still alive but would be culled, according to the data.

Kandow Hospital in Manado is preparing to treat people with bird flu symptoms although there have been no human infections in the province.

The North Sulawesi provincial administration also established a team in charge of conducting mass culls of chickens.

"This is in line with the fixed procedures applied nationally. Each poultry owner will get compensation of Rp 10,000 (US$1.05) per chicken that is culled," said Lucky Longdong, head of the North Sulawesi Agriculture and Livestock Office.
 

PCViking

Lutefisk Survivor
Shifting focus of blame...

China blames U.S. lab for delay in sharing H5N1 samples
Fri Sep 8, 2006 1:37 PM BST

HONG KONG (Reuters) - China, which has not shared bird flu virus samples with foreign experts since 2004, has blamed a U.S. laboratory for the long delay, saying it had not put in place import procedures, Chinese media said on Friday.

Citing the Ministry of Agriculture, the official China Daily newspaper said China had already prepared 20 samples for a laboratory at the U.S. Centers for Disease Control and Prevention (CDC), which is accredited by the World Health Organization.

"But the U.S. lab has not yet completed import procedures, causing an indefinite delay in the shipment of the virus," a ministry spokesman was quoted as saying.

China said this week it had not provided international health agencies with samples of bird flu viruses found in the country since late 2004, but was putting in place procedures to do so.

Health experts fear the H5N1 bird flu virus, which has killed at least 140 people worldwide since late 2003, will mutate into a form that can pass easily among humans, sparking a pandemic that could kill millions.

Scientists have long insisted that H5N1 samples should be shared to allow experts to trace the evolution of the virus and the geographical spread of any particular strain.

But those calls are not generally observed and the WHO is not empowered to oblige any government to share. Some scientists tend to be proprietary about samples, preferring to publish their findings in prestigious journals first.

The newspaper also quoted a ministry official recounting an incident in 2004, when China sent five samples to the WHO.

"But the WHO made the samples available to foreign researchers who twice published the genetic sequence and other data of four of the five samples without giving credit to Chinese scientists who made the genetic sequencing and did the analysis," the newspaper quoted the official as saying.

The WHO and the foreign researchers later apologized to the ministry, according to the newspaper.

http://today.reuters.co.uk/news/art...15_RTRUKOC_0_US-BIRDFLU-CHINA-USA.xml&src=rss

:vik:
 

Bill P

Inactive
The Center for Disease Control has published a .ppt:

http://www2.cdc.gov/phlp/conference...e Threat Reduction Agency Escape communities"

This summarizes the Univ Mich report on Escape Communitees (see link above) where the only Non Pharmaceutical Intervention that prevented the spread of 1918 pandemic flu was:

Protective Sequestration: Isolation of a population inside a "cordon sanitaire" with no entry or egress except by means of a quarentine for incomers.

Note that:

an island or remote location worked best.

success requires movement into the Escape community and establishment of cordon sanitaire prior to onset of local outbreak.

successful grouping is larger than single family.

successful organizational structure has a top down hierarchy for strict enforcement of rules, esp "cordon sanitaire" by those inside the Escape Community.

structured entertainment and alternatives to daily life for community members was deemed necessary.


After reading this, I wonder more and more about how some of us here that have individually stocked up for 6 months or more of self imposed sequestration will cope with the psyhcological issues of confinement.

I am recalling scenes from Stephen King's (Jack Nicholson) THE SHINING which IMO underscores the need for a larger group for longer periods of confinement.
 

PCViking

Lutefisk Survivor
WHO recognizes three bird flu cases in Indonesia
Fri Sep 8, 2006 5:01 PM BST

GENEVA (Reuters) - The World Health Organization (WHO) said on Friday that it had recognized three more cases of bird flu in Indonesia, one from June and two dating to 2005.

"The retrospectively confirmed cases bring the total in Indonesia to 63. Of these cases, 48 have been fatal,"
the WHO said in a statement. The national toll is the highest worldwide.

Bird flu remains essentially an animal disease, but scientists fear the H5N1 bird flu virus, which has killed 143 people since late 2003, could mutate into a pandemic strain capable of killing millions of people.

One case was that of a 14-year-old Indonesian girl who died in June, whom national authorities announced on Thursday had been infected with bird flu.

The case, in the South Sulawesi province, had taken a long time to identify because it was from blood samples taken during routine surveillance of people with mild influenza symptoms.


The WHO said she had had contact with poultry near her home.

The WHO also validated two bird flu cases in Indonesia dating to June 2005 and November 2005, thereby aligning itself with official figures of the country's health ministry.

Prior to the recent revision of WHO's case definitions for H5N1 infection, the cases had not met the United Nations health agency's criteria for serologically confirmed avian influenza infection, it said.

The June 2005 case was an eight-year-old girl from Banten province who died the following month and was part of a "family cluster" reported at the time, according to the WHO.

Her father, who also died in July 2005, was Indonesia's first laboratory-confirmed H5N1 positive human case. Her one-year-old baby sister also died at the time with similar symptoms but there was no word on Friday about the status of testing on her samples.

The other retrospectively confirmed case is a 45-year-old man from Central Java Province who developed symptoms in November 2005 following direct contact with diseased poultry, according to the WHO. He has recovered.

http://today.reuters.co.uk/news/art...24_RTRUKOC_0_US-BIRDFLU-INDONESIA.xml&src=rss

:vik:
 

Bill P

Inactive
If I am not mistaken, the offical WHO global death tally for confirmed H5N1 doesnt seem to be keeping pace with new reliable reports of additional deaths.

The "official" tally seems stuck for last few weeks on 143.
 

fruit loop

Inactive
Can't blame the guy

I'm more afraid of the medical establishment, being experimented on, or having forced "treatment" than I will ever be of dying of a disease.

Forcing people to take Tamiful is also a waste....it doesn't work on everyone. I've taken it twice to no effect except an upset stomach. I won't ever bother with it again.

Frankly, I think this BIRRRRRRD FLUUUU!!!!!!!!!!!!!!!!!! is overhyped.

All we hear about are the DEATHS. Most people who have flu never seek treatment, so we have no way of knowing how many people had the disease, recovered, and never knew it.
 

Bill P

Inactive
Just for the record, I dont think this is an accurate statement regarding HPAI H5N1:
so we have no way of knowing how many people had the disease, recovered, and never knew it.

Scientists from a variety of different nations and different health .orgs have looked for and not found large populations of humans that have had HPAI H5N1 and recovered. The disease leaves tell tale signs of antibodies in the blood for a long time.

I actually believe that the HPAI H5N1 has been deliberately underhyped to avoid panic.

If you follow the news, the proximity of a pandemic worse than 1918 is alot closer than is reported in the MSM.

You understand that H5N1 is not the common flu dont you? I think we had this conv before....
 
Top