05/10 | Daily BF: "Most cases in humans have been young, reminiscent of 1918"

PCViking

Lutefisk Survivor
Link to yesterday's thread: http://www.timebomb2000.com/vb/showthread.php?t=196696

Human Cases

Since January, 2004 WHO has reported human cases of avian influenza A (H5N1) in the following countries:

* East Asia and the Pacific:
o Cambodia
o China
o Indonesia
o Thailand
o Vietnam

* Europe & Eurasia:
o Azerbaijan
(see update)
o Turkey

* Near East:
o Egypt
o Iraq

For additional information about these reports, visit the
World Health Organization Web Site.

Updated April 3, 2006

Animal Cases

Since December 2003, avian influenza A (H5N1) infections in poultry or wild birds have been reported in the following countries:

* Africa:
o Burkina Faso
o Cameroon
o Niger
o Nigeria
o Sudan

* East Asia & the Pacific:
o Cambodia
o China
o Hong Kong (SARPRC)
o Indonesia
o Japan
o Laos
o Malaysia
o Mongolia
o Myanmar (Burma)
o Thailand
o Vietnam

* South Asia:
o Afghanistan
o India
o Kazakhstan
o Pakistan

* Near East:
o Egypt
o Iraq (H5)
o Iran
o Israel
o Jordan

* Europe & Eurasia:
o Albania
o Austria
o Azerbaijan
o Bosnia & Herzegovina
o Bulgaria
o Croatia
o Czech Republic (H5)
o Denmark
o France
o Georgia
o Germany
o Greece
o Hungary
o Italy
o Poland
o Romania
o Russia
o Serbia & Montenegro
o Slovak Republic
o Slovenia
o Sweden
o Switzerland
o Turkey
o Ukraine
o United Kingdom


For additional information about these reports, visit the
World Organization for Animal Health Web Site.

Updated April 24, 2006

http://www.cdc.gov/flu/avian/outbreaks/current.htm

WHO, Avian Flu Timeline in .pdf: http://www.who.int/csr/disease/avian_influenza/timeline.pdf

:vik:
 

PCViking

Lutefisk Survivor
Biologist: Bird flu pandemic will hit young people

TORONTO - One of Canada's top microbiologists warned on Tuesday that school-age children would be most at risk in a bird flu pandemic, echoing a 1918 pandemic that killed millions of people.

"Most cases in humans have been young, reminiscent of 1918,"
Donald Low, microbiologist-in-chief at Toronto's Mount Sinai Hospital, said in a speech in Toronto.

The H5N1 strain of avian flu that is spreading among birds does not easily infect humans, but it has killed more than 100 people. Experts, including Low, fear it could mutate in to a form that could spread easily and quickly among people.

"The attack rate in a pandemic will be up to 30 percent, and will be highest among school-age children," said Low, who coordinated Toronto's fight against SARS in 2003.

Toronto was the only city outside Asia where people died of Severe Acute Respiratory Syndrome. The disease infected 375 people in the city and killed 44.

The 1918-19 Spanish flu pandemic killed between 20 million and 50 million people worldwide. Reuters

http://www.abs-cbnnews.com/storypage.aspx?StoryId=38245

:vik:
 

PCViking

Lutefisk Survivor
State to test wild birds for avian flu
Update 6:04 pm
Staff report
05/09/2006

State monitoring for avian influenza will extend to Delaware’s wild bird populations this summer, as government agencies work to head off a potential outbreak and global epidemic among humans.

Division of Fish and Wildlife Director Patrick Emory said tracking will begin this summer and continue through fall and winter waterfowl migrations.

About 1,000 waterfowl and shorebirds will be tested this year, including checks of captured birds and dead birds. Some hunters also may be asked to provide samples from birds they take during regular seasons.

Recent outbreaks of avian influenza in Asia, Europe and other parts of the world have increased concern that an aggressive strain of the disease will jump from birds to humans, confronting the world with a new type of flu for which people have no natural immunity.

Emory said that hunters or citizens should stay informed about the disease, take precautions in handling and cleaning birds and notify the division if they encounter groups of sick or dead birds. Individual dead birds are not currently a focus of the monitoring program, however.

http://www.delawareonline.com/apps/pbcs.dll/article?AID=/20060509/NEWS/60509046/1006

:vik:
 

PCViking

Lutefisk Survivor
Indonesia

Bird flu rife in Indonesia

Mon, 08 May 2006

Indonesia's 25th bird flu death has been confirmed by World Health Organization tests, a health ministry official said on Monday.

"We were contacted by the WHO office in Jakarta yesterday over the laboratory results of the 30-year-old man who died on April 26, which came out positive," Joko Suyono of the health ministry's bird flu information center told AFP.

"He is confirmed as Indonesia's 25th bird flu fatality."

The man, a resident of Jakarta's satellite town of Tangerang, had a history of contact with sick poultry and died at the capital's main hospital for the treatment of bird flu patients.

Indonesia, the world's fourth most populous nation, has witnessed more bird flu deaths than any other country this year and has the second highest number of fatalities reported in the world since 2003, after Vietnam.

WHO's Asia chief last weekend warned that the sprawling archipelago nation needed to work harder at the grassroots level to act against H5N1.

The head of the World Organisation for Animal Health warned last month meanwhile that Indonesia was a "time-bomb" because of its failure to eradicate the virus from numerous areas.

Most cases in Indonesia have been in the capital and its surroundings, where many people live in close proximity to poultry despite the urban environment.

Experts fear that bird flu, which has killed more than 100 people since late 2003, mostly in Asia, may mutate into a form that can pass easily between humans, sparking a deadly pandemic.

AFP

http://iafrica.com/news/worldnews/300674.htm

:vik:
 

JPD

Inactive
Evolution of Qinghai H5N1 Bird Flu

http://www.recombinomics.com/News/05090602/H5N1_Qinghai_Evolution.html

Recombinomics Commentary
May 9, 2006

Today is the one year anniversary of the reporting of the H5N1 outbreak at Qinghai Lake. In the past 12 months the Qinghai strain of H5N1 has migrated through Russia, Mongolia, Kazakhstan, Europe, the Middle East, and Africa. This explosion is without precedent and was driven by H5N1 in long range migratory birds.

The sequences of 16 isolates from Qinghai Lake were made public in July. Although the genes were most closely related to H5N1 from South Korea/ Japan or Guangdong Province in China, the sequences were unique and had some polymorphisms linked to Vietnam and others to isolates from Europe.

The isolates were particularly virulent, killing experimental chickens in 20 hours or less, and killing experimental mice in 3-4 days. The lethality in mice may have been linked to a polymorphism that had not been seen previously in H5N1 isolates from birds. PB2 E627K was a human polymorphism and was present in all H1, H2, and H3 isolates from humans. It was also in some H5N1 isolates from patients or cats and was associated with a poor prognosis. Almost all mammalian infections were fatal. In addition, lab experiments showed that E627K was associated with virulence in mice and the polymorphism increased polymerase activity at lower temperatures (33 C).

As noted in the summary on the Qinghai strain emergence, the Qinghai outbreak was followed by outbreaks in nature reserves in Russia and Mongolia. The presence of H5N1 in over 2 dozen bird species in southern Siberia suggested that H5N1 would soon spread through Europe, the Middle East, and Africa.

At the beginning of 2006, the first human case of Qinghai H5N1 was reported. The cluster in Turkey was large and the H5 had acquire S227N, a change in the receptor binding domain that increased binding for human receptors in the upper respiratory tract. This change was predicted because H9N2 isolates in the Middle East contained donor sequence that would allow recombinants to acquire this change.

S227N was not reported in subsequent Qinghai H5N1 isolates in the area, including human isolates from Iraq and Egypt. Qinghai isolates did have some regional differences, but most of the regional polymorphisms traced back to H5N1 in Asia. However, there were some North American polymorphisms, suggesting that H5N1 had moved into North America earlier in the season.

Qinghai isolates have also been reported in Liaoning Province in China. However, the human cases in China had sequences found in the Fujian strain of H5N1. This strain has recently also been noted in Laos and Malaysia. Thus, China has two strains co-circulating that case H5N1 infections in humans.

Recent sequence data on a human isolate from Indonesia identifies yet another H5N1 strain. This strain has a genetic background that matches earlier isolates from Indonesian poultry, but the human isolate has additional polymorphisms found in Vietnam, Thailand, and wild bird isolates in China, including the Qinghai strain. Thus, H5N1 in China frequently recombines with other H5N1 isolates to rapidly evolve.

Recent reports from Qinghai province indicated new H5N1 infections were found in bar headed geese in two counties. These recent infections signal migration back to Qinghai, which will come from India as well as east and southeast Asia. These birds will then migrate to Chany Lake in southern Siberia, where there will be H5N1 infected birds from Europe, the Middle East and Asia.

This in the first 12 months many of the Qinghai isolates flew into regions where H5N1 had not been previously reported. H5N1 was seeded locally on these regions, but the H5N1 will be returning to Russia to mix with H5N1 from Qinghai Lake, leading to significant evolution in the Qinghai strain, which will then migrate south in the fall into regions where H5N1 was seeded in the past 12 months.
 

JPD

Inactive
The Emergence and Spread of Qinghai H5N1 Bird Flu​

http://www.recombinomics.com/News/05090601/H5N1_Qinghai_Emergence.html

Recombinomics Commentary
May 9, 2006

Today is the one year anniversary of the report of 189 dead bar headed geese at Qinghai Lake in China. Although H5N1 infection was initially denied, China filed an OIE report on May 21, 2005 indicating that H5N1 was detected in the bar headed geese as well as four additional species of waterfowl, and the number of dead birds was 519. This report was followed by a series of news conferences that quickly raised the total to over 1000 followed by a final number of over 5000 dead birds.

The bird die off at Qinghai Lake was without precedent. Usually wild waterfowl are resistant to H5N1 and the die-off signaled a major change in the transmission of highly pathogenic H5N1 because the dead birds were long range migratory waterfowl. Most of the dead birds were bar headed geese which fly over 1000 miles in 24 hours. Recently H5N1 has again been reported in two counties in Qinghai Province, signaling the completion of one season of H5N1 spread of the Qinghai strain of H5N1.

The Asia strain of H5N1 was first reported in a Guangdong goose in 1996. This report was followed by an outbreak of H5N1 in 1997 in adjacent Hong Kong which infected 18, 6 of whom died. Culling of all poultry in Hong Kong halted reported human cases until 2003, but H5N1 was frequently found in Hong Kong , resulting in repeated culls and signaling H5N1 spread in China.

In 2003 a Hong Kong family that traveled to Fujian Province was infected with H5N1. The isolated virus was similar to the 1997, but quite distinct. The export of H5N1 into a visiting family signaled additional H5N1 in China, but H5N1 was not reported until it exploded into adjacent countries in 2004. Vietnam and Thailand were hardest hit, but H5N1 was also reported in adjacent Cambodia, Laos, and Malaysia as well as Hong Kong, South Korea, Japan, Indonesia, and many provinces in China.

H5N1 had changed again. One version was in southeast Asia (Vietnam, Thailand, Laos, Cambodia, Malaysia), while another version was in South Korea, Japan, Hong Kong China, and Indonesia, although there were also regional differences outside of southeast Asia.

All human cases however were reported in Vietnam and Thailand in 2004. Cambodia also reported human cases in early 2005 and all human isolates were closely related.

The H5N1 isolated at Qinghai Lake was distinct. Although it had many of the features in the east and southeast Asian versions, it also had sequences that had been found in European isolates. In addition Qinghai isolates had a change (PB2 E627K) that had never been reported in H5N1 from birds. All prior H5N1 with this change was from H5N1 from mammals, including humans. It was also found in all human serotypes (H1, H2, H3) isolated from humans.

Thus, the Qinghai strain of H5N1 was easily distinguished from the H5N1 to the east, but its ability to be transported and transmitted over long distances was unclear. Its high lethality may have cause it to burn out at Qinghai Lake. However, the large number of waterfowl that visit Qinghai Lake in the spring discounted this possibility and the Qinghai outbreak in May was followed by reports of fatal H5N1 infections in farm ducks in Xinjiang province, northwest of Qinghai Lake. The fatal infections in domestic waterfowl strongly suggested that the Qinghai strain of H5N1 was migrating towards southern Siberia, where many birds from Qinghai Lake summer. This possibility was confirmed in July when Russia reported H5N1 infections in farms surrounding Chany Lake in southern Siberia (see summary of OIE reports on Qinghai strain of H5N1 bird flu).

The outbreak in Russia was supported by similar reports of H5N1 in region of Kazakhstan adjacent to Chany Lake as well as dead birds at nature reserves in Mongolia, including Erhel Lake. OIE reports out of Russia indicated the H5N1 infections were extensive, covering a series of southern provinces. Sequence data confirmed that the outbreaks in Russia, Kazakhstan, and Mongolia were all due to the Qinghai strain of H5N1. Reports from Russia also indicated that H5N1 was also found in two dozen species of wild birds shot by hunters, indicating H5N1 could be both transmitted and transported by long range migratory birds.

The reports from Russia in August left little doubt that H5N1 would soon be migrating into Europe. Early reports cited H5N1 in the Volga Delta and the intersection of migratory bird flyways in the southern Siberian region of Russia left little doubt that the migration of H5N1 into new areas of Europe, the Middle East, and Africa would happen in the fall and winter.

These predictions were confirmed with reports of H5N1 in Romania, Croatia, and Turkey in the fall. The sequence data again confirmed that the new outbreaks were due to the Qinghai strain. Ukraine also reported H5N1, and these reports raised serious doubts about surveillance in European and Middle East countries which claimed to be H5N1 free.

At the beginning of 2006, human cases were reported in Turkey. These reports were followed by OIE reports from Turkey indicating H5N1 had been widespread in eastern Turkey since mid November. These reports cast further doubt on claims of neighboring countries that they were H5N1 free since the birds in Turkey had passed over many H5N1 countries and had then traveled over the Middle East into Africa.

By the end of January, reports of H5N1 in Europe began to appear and these reports were followed by a flurry of reports in February. Reports of H5N1 in the Middle East and Africa also began to appear and the number of countries reporting H5N1 for the first time was without precedent.

Reporting countries described H5N1 in a large number of wild and domestic species and raised additional surveillance questions about denials from neighboring countries. Human cases were reported in Turkey, Iraq, Azerbaijan, Jordan, and Egypt.

H5N1 is now beginning to migrate back north, out of Africa into western Europe and North America as well as out of eastern Asia into Qinghai Lake. This will be followed by further migration into southern Russian by H5N1 from Asia, India, Africa, and Europe. The interactions at Qinghai Lake in China and Chany Lake in Russia, should lead to significant evolution of H5N1 in the upcoming months, setting the stage for a new round of migrations in the fall.
 

Fuzzychick

Membership Revoked
Cytokine storms, the body's immune response to invasion, will be the end of those many young with intact immune systems...sadly our children and those under 40 are most at risk...age will definitely against many because their bodies will attempt to fight it off, I've heard the stories from my great grandparents, funny they told me to watch out for it when I became an adult........the cycle continues..
 

Fuzzychick

Membership Revoked
Fair use for education applies:




Trivia: Cytokine Storms By The MedHunters Ezine Team


The expression "too much of a good thing is bad for you" can be used to describe the effect of a cytokine storm on our bodies.

Cytokines are proteins that alert our immune system to the presence of a foreign a body, such as a virus or bacteria. Normally, when we become infected, our body will send T-cells to mark or attack the foreign body or antigen. However, during a cytokine storm, our body overreacts and attacks itself via a flood of T-cells and the products that they release.

For example, the white scaly plaques and reddish patches of skin that characterize psoriasis lesions are an autoimmune response provoked by a cytokine storm. The scales occur when cytokines tell the body to reproduce skin in certain areas at an accelerated rate. The body accommodates this request, and the skin that is produced piles up on top of itself as dead cells.

But there are conditions far more serious than psoriasis that can involve cytokine storms. Currently, researchers are interested in the mechanism of these storms because of the historical role that they played in deaths during the Spanish flu pandemic of 1918, and fears that they will represent a similarly destructive factor in an Avian flu pandemic, if one were one to happen.

One of the most striking aspects of the Spanish flu was that the majority of those it killed were between the ages of 18 to 40 years – people assumed to be at lesser risk than the old or the very young, whose immune systems tend to be relatively weaker.

Paradoxically, what would normally make individuals susceptible to illness – weaker immune systems – actually made them less susceptible to death. It's now believed that the Spanish flu virus induced a cytokine storm in sufferers, which signaled their bodies to attack their lungs, which led to acute respiratory distress syndrome. Those with relatively strong immune systems – the normally healthy, young, 18- to 40-year-olds – were, as a result, at a greater risk of dying than were others. (For more information, see the May 5, 2005 article Preparing for the Next Pandemic, by Michael T. Osterholm, PhD, MPH, of the School of Public Health, University of Minnesota, and current Director of the Center for Infectious Disease Research and Policy.)


MedHunters Email: info@medhunters.com Call Us: 1-800-664-0278 Contact Info Terms of Use Privacy Policy Signup for our newsletter Photo credits for this page

© 1996-2004 MedHunters. All rights reserved.
 

JPD

Inactive
China steps up bird flu monitoring, WHO still worried

http://today.reuters.com/news/newsA...RTRUKOC_0_US-BIRDFLU-CHINA.xml&archived=False

By Ben Blanchard

BEIJING (Reuters) - China has stepped up monitoring for bird flu in the remote northwestern province of Qinghai, state media said on Wednesday, as the WHO said it remained concerned and that now was not the time to be complacent.

Health authorities have tightened controls in Yushu county, about 500 miles from the provincial capital Xining, where an outbreak of the H5N1 strain among wild birds was reported last week, Xinhua news agency said.

Qinghai has become a major focus for scientists studying mutations of the H5N1 virus.

A year ago, scientists believe a mutated form of the virus killed thousands of wild birds at Qinghai Lake, a major stop-off point for migratory birds in the province's barren northeast.

Soon after the mass die-off of birds in late April and May 2005, the virus rapidly spread West to Europe and then to the Middle East and Africa, underscoring the importance of monitoring what's happening at the lake, and elsewhere in China.

The World Health Organization (WHO) says the Qinghai Lake form of the H5N1 virus is almost identical to the strain found in recent outbreaks in Nigeria, Iraq and Turkey.

Prior to the Qinghai Lake event, H5N1 was known to cause occasional sporadic deaths in migratory waterfowl, but not to kill them in large numbers or be carried by them over long distances, the WHO has said.

"The birds are on the move. This is the breeding and nesting time, so we wouldn't be surprised to see more reports in wild birds and possibly also reports in domestic poultry," said Julie Hall, the WHO's China bird flu coordinator.

"This is a virus that is unstable and unpredictable," she said.

AT RISK

Experts fear that bird flu could mutate into a form that passes easily among humans, potentially triggering a pandemic in which millions could die.

In China, 12 people are known to have died of bird flu and six have survived. Worldwide, 115 people have died in nine countries. The virus remains a disease in birds and is hard for humans to catch.

"We're still seeing approximately one human case per week even if we're not hearing of reports of animal disease. Clearly the virus is still circulating in some parts of China," Hall said.

China has reported almost 40 outbreaks of bird flu in poultry across a dozen provinces over the past year. Health experts see the country as being particularly at risk because of its huge human population and many poor, remote areas.

As in many other parts of Asia, domestic poultry often live cheek by jowl with humans in China, increasing the risk of transmission to people through contact with sick birds.

"Animal surveillance remains extremely important and there is probably even greater need for enhanced surveillance now because although reports of animal outbreaks are on the decrease, we are still seeing human cases," Hall said.

China was being a lot more open with sharing information and samples, she added, even if there remained areas of concern.

"Things are progressing. Relations with the Ministry of Health are good and they're certainly sharing viruses," Hall said.

In March, the WHO said that China had agreed to share virus samples from outbreaks in poultry to meet a request the country go beyond sending samples collected from people and help global efforts to limit the spread of the disease.

"The Ministry of Agriculture is in the process of catching up in terms of what has not been shared for a year to 18 months. We hope that this is a sign that in the future there will be more timely and easier sharing of information and viruses," Hall said.
 

JPD

Inactive
H5N1 in blood might open way for new test - experts

http://in.today.reuters.com/news/ne...R_RTRJONC_0_India-248551-1.xml&archived=False

By Tan Ee Lyn

HONG KONG (Reuters) - Scientists in Thailand have detected live H5N1 bird flu virus in the blood of a boy who died in December, a discovery that might lead to a safer way to diagnose the disease in humans.

At present, respiratory secretions are collected to test for the H5N1 virus. But that practice, which is physically irritating, can result in the patient coughing violently and spraying the virus, infecting doctors and nurses conducting the procedure.

During SARS in Hong Kong in 2003, scores of healthcare workers ended up infected when they carried out intubation on patients. Intubation is the procedure of passing a breathing tube through the mouth or nose and down the throat. The tube is then used to pass oxygen into the lungs and help a person breathe.

Parvapan Bhattarakosol, a member of the Thai team and a microbiologist from Chulalongkorn University, said a huge amount of live H5N1 virus in the blood plasma of the five-year-old boy was detected more than 12 days after the sample was collected.

This is unusual. According to other microbiologists, respiratory viruses generally are not present in the blood stream after such a long time because they are confined to the respiratory tract and do not replicate well in the blood.

Bhattarakosol also called for the scientific community to study if blood samples can be a reliable means for diagnosis.

"If we can find virus in blood, so maybe blood is another type of sample that we can take and use for diagnosis, instead of using only respiratory secretions," she told Reuters.

"It is easily done and better than taking respiratory secretions, which can be dangerous because it is the secretions that are very infectious."

"There must be another study to see if blood is a suitable sample. If there are other cases of human H5N1, we should draw blood samples and try to detect the virus in blood and then we can see if blood is suitable as a diagnostic test."

MULTI-ORGAN FAILURE

The finding, to be published in the June issue of the Centers for Disease Control and Prevention's Emerging Infectious Diseases Journal, might explain why H5N1 victims suffer from systemic infections, when the virus spreads throughout the body and victims die from multi-organ failure.

"When viruses get into blood, there is a risk of all organs in the body being affected," Bhattarakosol said.

There are implications for blood donation and people working with blood samples too. Although 207 people have reportedly been infected since late 2003, and 115 of them have died, scientists say many mild cases of H5N1 infection might have gone undetected.

In Hong Kong, where the virus made its first known jump to humans and killed six people in 1997, later tests showed some hospital workers and others who had not fallen sick during the period carrying H5N1 antibodies -- which means they were infected.

"We should keep this (that H5N1 can live in blood) in mind when donating blood or blood transfusions," Bhattarakosol said.

But Julian Tang, a microbiologist at the Chinese University in Hong Kong, said the finding gave reasons to be optimistic.

In systemic infections, such as those caused by chickenpox or measles, viruses might last longer than a week in the blood stream, allowing for the production of T and B memory lymphocytes in the patient's immune system, which tend to produce lifelong immunity.

"If avian H5N1 influenza produces a detectable blood viraemia for several days, then the response to an H5N1 vaccine may be more long-lasting and protective, than the response to other non-H5N1 influenza vaccines, as there will be a more intense antigenic stimulation to produce specific T and B memory lymphocytes," Tang said.

Lymphocytes, the blood cells that make antibodies, have memory cells and this function allows them to remember a past encounter with the H5N1 strain, and produce antibodies to neutralise the virus in future encounters, experts say.

"Those who survive avian H5N1 influenza may be more effectively protected for a longer period against the same strains of H5N1 (i.e. naturally acquired immunity), should they be re-exposed to the same strain in the near future."
 

PCViking

Lutefisk Survivor
H5N1 in blood might open way for new test

By Tan Ee Lyn
Wed May 10, 4:23 AM ET

Scientists in Thailand have detected live H5N1 bird flu virus in the blood of a boy who died in December, a discovery that might lead to a safer way to diagnose the disease in humans.

At present, respiratory secretions are collected to test for the H5N1 virus.
But that practice, which is physically irritating, can result in the patient coughing violently and spraying the virus, infecting doctors and nurses conducting the procedure.

During SARS in Hong Kong in 2003, scores of healthcare workers ended up infected when they carried out intubation on patients. Intubation is the procedure of passing a breathing tube through the mouth or nose and down the throat. The tube is then used to pass oxygen into the lungs and help a person breathe.

Parvapan Bhattarakosol, a member of the Thai team and a microbiologist from Chulalongkorn University, said a huge amount of live H5N1 virus in the blood plasma of the five-year-old boy was detected more than 12 days after the sample was collected.

This is unusual. According to other microbiologists, respiratory viruses generally are not present in the blood stream after such a long time because they are confined to the respiratory tract and do not replicate well in the blood.


Bhattarakosol also called for the scientific community to study if blood samples can be a reliable means for diagnosis.

"If we can find virus in blood, so maybe blood is another type of sample that we can take and use for diagnosis, instead of using only respiratory secretions," she told Reuters.

"It is easily done and better than taking respiratory secretions, which can be dangerous because it is the secretions that are very infectious."

"There must be another study to see if blood is a suitable sample. If there are other cases of human H5N1, we should draw blood samples and try to detect the virus in blood and then we can see if blood is suitable as a diagnostic test."

MULTI-ORGAN FAILURE

The finding, to be published in the June issue of the Centers for Disease Control and Prevention's Emerging Infectious Diseases Journal, might explain why H5N1 victims suffer from systemic infections, when the virus spreads throughout the body and victims die from multi-organ failure.

"When viruses get into blood, there is a risk of all organs in the body being affected,"
Bhattarakosol said.

There are implications for blood donation and people working with blood samples too. Although 207 people have reportedly been infected since late 2003, and 115 of them have died, scientists say many mild cases of H5N1 infection might have gone undetected.

In Hong Kong, where the virus made its first known jump to humans and killed six people in 1997, later tests showed some hospital workers and others who had not fallen sick during the period carrying H5N1 antibodies -- which means they were infected.

"We should keep this (that H5N1 can live in blood) in mind when donating blood or blood transfusions," Bhattarakosol said.

But Julian Tang, a microbiologist at the Chinese University in Hong Kong, said the finding gave reasons to be optimistic.

In systemic infections, such as those caused by chickenpox or measles, viruses might last longer than a week in the blood stream, allowing for the production of T and B memory lymphocytes in the patient's immune system, which tend to produce lifelong immunity.

"If avian H5N1 influenza produces a detectable blood viraemia for several days, then the response to an H5N1 vaccine may be more long-lasting and protective, than the response to other non-H5N1 influenza vaccines, as there will be a more intense antigenic stimulation to produce specific T and B memory lymphocytes,"
Tang said.

Lymphocytes, the blood cells that make antibodies, have memory cells and this function allows them to remember a past encounter with the H5N1 strain, and produce antibodies to neutralize the virus in future encounters, experts say.

"Those who survive avian H5N1 influenza may be more effectively protected for a longer period against the same strains of H5N1 (i.e. naturally acquired immunity), should they be re-exposed to the same strain in the near future."

http://news.yahoo.com/s/nm/20060510...wIhANEA;_ylu=X3oDMTA5aHJvMDdwBHNlYwN5bmNhdA--

:vik:
 

JPD

Inactive
Governments try to calm fears about bird flu
following alarming TV movie

http://www.sun-sentinel.com/feature...u10may10,0,809763.story?coll=sfla-news-health

By Nancy McVicar
South Florida Sun-Sentinel Health Writer
Posted May 10 2006

Bird flu has not made it to North America in any form -- except in a fictional ABC movie, Fatal Contact, Bird Flu in America, which aired Tuesday night depicting what might happen in a worst-case scenario.

But federal and state health officials tried to calm fears Tuesday by saying the movie is not a documentary and is meant to entertain, and that the flu virus -- H5N1, which has made birds sick in other parts of the world -- has not mutated into a form that can be easily transmitted to people.

Federal health officials approved a postscript to the movie:

"To date, there have been no cases of the H5N1 virus in the United States nor has there been a human transmission of the disease in a form that could fuel a pandemic. However, experts around the world are monitoring the avian flu situation closely and are preparing for the possibility that the virus could begin to spread from person to person. For information on the virus log onto pandemicflu.gov"

Florida health officials, who had not seen the movie, took the opportunity Tuesday to allay the public's fears and at the same time explain that if the virus does become a threat to humans, plans are being made to help deal with it.

Dr. Rony Francois, secretary of the Florida Department of Health, said historically a global flu occurs every 30 to 40 years. Francois said that while the movie was meant to entertain, it could "act as a catalyst for each of us to prepare our families."

He suggested that when people shop for their weekly groceries, they gradually stock up on supplies of food and water that would be necessary for survival during a bird-flu outbreak.

The state, counties and federal government health agencies have been conducting exercises, practicing how they would handle a flu outbreak that is different from the normal flu that occurs every year, he said, and a statewide surveillance program in place that would identify bird flu quickly if it arrived here.

"We have a rapid test for H5N1 that takes hours rather than days for a preliminary result. We have epidemiologists, disease investigators located at county health departments across the state," Francois said.

Senior officers from the federal Centers for Disease Control and Prevention are also working with the state, he said.

"We are exercising, testing and evaluating our plans on both a state and local level across Florida," Francois said.

Broward County and Palm Beach County health departments said they are prepared to answer any questions residents have that might result from viewing the movie.

"We are available. It is a movie, designed to be entertaining," said Tim O'Connor, a spokesman for the Palm Beach County Health Department, "but if they call in with questions, they will be referred to someone who can answer them."

Candy Sims, a spokesperson for the Broward County Health Department, said she would help to field any calls.

"I just hope the general public isn't going to panic," Sims said.
 

JPD

Inactive
ABC TV Movie: Fatal Contact: Bird Flu in America

http://www.pandemicflu.gov/news/birdfluinamerica.html

The Viewer Guide from the Department of Health and Human Services begins by reiterating that the ABC program "is a movie, not a documentary. It is a work of fiction designed to entertain and not a factual accounting of a real world event."

"While the movie does serve to raise awareness about avian and pandemic flu, we hope it will inspire preparation -- not panic," the guide continues. "There are steps individuals, families and communities can take to prepare. You can keep a supply of food and medicines on hand in case you have to stay home, you can practice good public health measures like frequent hand washing and staying home when sick."

Viewer's Guide:

The ABC Movie "Fatal Contact: Bird Flu in America" is a movie, not a documentary. It is a work of fiction designed to entertain and not a factual accounting of a real world event.

There is no influenza pandemic in the world at this time.

Also, it is important to remember that H5N1 avian influenza is almost exclusively a disease of birds. The H5N1 virus has not yet appeared in the U.S.

Should the H5N1 virus appear in the U.S., it does not mean the start of a pandemic.

An additional point to remember is that the next influenza pandemic could be substantially less severe than what the movie depicts or that occurred in 1918. For example, the influenza pandemics of 1957/58 and 1968/69 caused so much less illness and death than did the 1918/19 pandemic that many Americans at that time did not distinguish them from seasonal influenza and were unaware that a pandemic was underway.

While the movie does serve to raise awareness about avian and pandemic flu, we hope it will inspire preparation - not panic. There are steps individuals, families and communities can take to prepare. You can keep a supply of food and medicines on hand in case you have to stay home, you can practice good public health measures like frequent hand washing and staying home when sick. There is good information available on www.pandemicflu.gov.

The film does depict scenarios that could unfold should a severe pandemic ever develop, including limited availability of antivirals and vaccines as well as the potential for disruption of supplies, medicines and other essential services.

The film also illustrates the expected months-long delay in developing an effective vaccine against a pandemic strain of influenza once it emerges. This is why, at the President's request, the Congress approved funding for the Department of Health and Human Services to make significant financial investments to improve the technology for vaccine development and to build up our domestic vaccine production capacity, to ensure more rapid availability of vaccine for the population in a pandemic.

The film highlights an important aspect of planning - individual and community planning and cooperation that will be so vital to sustaining communities and neighborhoods during an extended wave of an influenza pandemic. HHS has developed an extensive set of planning documents, including planning checklists for businesses, schools, health care providers, community organizations and states as well as an individual and family planning guide. All of these materials are available at www.pandemicflu.gov.

While the H5N1 virus has not yet appeared in the U.S., and there is no influenza pandemic in the world at this time, it is important for all Americans to be informed about this potential public health threat and some of the steps individual Americans can take to protect themselves and their families in the event of a pandemic.

Questions & Answers

Many people in the movie are seen wearing surgical masks. Will masks protect me?

Surgical masks are recommended for health care workers who are subjected to repeated exposure to multiple patients. For health care workers performing certain medical procedures on infected patients, N95 respirators are recommended. Surgical masks are also recommended for patients who are infected to help reduce the potential for spread of virus when these people cough or sneeze. HHS will continue to review and update as needed its public health guidance on the use of masks and respirators by healthcare workers and by the general public.

The movie shows the virus spreading in many ways besides coughing or sneezing, such as handshakes, kissing, sharing drinks, etc. Is that correct?

Influenza virus is primarily spread by airborne droplets that reach the eyes, nose or mouth but can also spread by touching contaminated surfaces and then touching one's face. This highlights the importance of learning and practicing good personal hygiene, including:

* Wash hands frequently with soap and water.
* Cover your mouth and nose with a tissue when you cough or sneeze.
* Put used tissues in a waste basket.
* Cough or sneeze into your upper sleeve if you don't have a tissue.
* Clean your hands after coughing or sneezing. Use soap and water or an alcohol-based hand cleaner.
* Stay at home if you are sick.

The film indicates that there will be a shortage of Tamiflu® (or other antivirals) in a pandemic. Will there be? And if so, what is the government doing to prevent that?

HHS is stockpiling enough antivirals to treat 25% of the U.S. population should a pandemic occur in the U.S. This figure is based on historical data from past pandemics indicating that roughly 25% of the population would get sick in a pandemic and would benefit from antiviral treatment if started early in the course of illness. To date, the U.S. government has purchased 26 million antiviral treatment courses and expects to have on hand a total of 81 million treatment courses by the end of 2008.

In the movie officials quickly find out that there is no vaccine available when the pandemic occurs nor will any be available for many months. Will we have vaccine available if a pandemic occurs?

There likely will be no vaccine initially available that precisely matches the pandemic strain when a pandemic begins. Because influenza viruses continually evolve and mutate, it is not possible to develop a vaccine until after the pandemic strain actually comes into existence. Only after the strain emerges, is isolated and characterized can a vaccine be developed and manufactured. Based upon current vaccine production processes and capacities, it will take at least 6 months to begin producing pandemic vaccine once a pandemic strain occurs.

HHS has been developing and stockpiling an experimental "pre-pandemic" H5N1 vaccine that may offer some level of immune protection should the H5N1 virus mutate into a pandemic strain. Having a stockpile of this vaccine for up to 20 million people, may help delay or lessen the initial impact of a pandemic while vaccine against the actual pandemic strain is developed and produced.

However, HHS is making significant financial investments to improve the technology for vaccine development and to build up our domestic vaccine production capacity, to ensure more rapid availability of vaccine for the population in a pandemic.

Many neighborhoods were quarantined in the film. Even the Governor of Virginia quarantined himself, his staff and his family from the rest of the world. Will the government quarantine people in a pandemic?

The purpose of quarantine is to separate people who have been potentially exposed to a contagious disease and may be infected but are not yet ill to stop the spread of that disease. The last large-scale quarantine measures that were imposed in this country were used in the early 20th century to contain outbreaks of plague, yellow fever, and smallpox.

Today, quarantine typically refers to confining potentially infected persons to their homes or community-based facilities, usually on a voluntary basis. Quarantine can be used for a defined group of people who may have been exposed at a public gathering, or who may have been exposed while traveling, particularly overseas. In extreme cases, quarantine could apply to an entire geographic area, in which case a community may be closed off by sealing its borders or by a barricade, known as a "cordon sanitaire".

In the case of pandemic influenza, quarantine may be one of the public health tools employed in the early days of an emerging pandemic if efforts are undertaken to contain the outbreak before it spreads too widely. Once a pandemic has begun to spread, quarantine is not likely to be effective in controlling the spread, and instead efforts may turn to "social distancing." Social distancing includes measures to increase distance between individuals, such as staying home when ill unless seeking medical care, avoiding large gatherings, telecommuting, and school closures.

In the movie, we learn that the virus is beginning to develop resistance to Tamiflu®, rendering the drug useless. Could that happen? If so, why are we buying so much Tamiflu® for the stockpile?

Tamiflu®, and another antiviral, Relenza®, have shown effectiveness in treating influenza. Early evidence suggests that Tamiflu® may be effective in treating those patients who have been infected with the H5N1 avian flu virus. While there have been a few reports of Tamiflu® resistance developing on therapy, there has been no transmission of a resistant virus. The resistance developing on therapy has been associated with starting the drug late or using low doses of this drug. Tamiflu®, when used at proper doses and started within a few days of the appearance of symptoms should be effective treatment of this infection.

Relenza® has not been used in treating human H5N1 cases to date, as it has been unavailable in many countries that have had people infected with H5N1. But experts expect it would be an effective treatment also.

HHS is stockpiling enough antivirals to treat 25% of the U.S. population should a pandemic occur in the U.S. This figure is based on historical data from past pandemics indicating that roughly 25% of the population would get sick in a pandemic. To date, the U.S. government has purchased 26 million antiviral treatment courses and expects to have on hand a total of 81 million treatment courses by the end of 2008. Of its antiviral purchases, the U.S. is buying approximately 80% of its supply as Tamiflu® and about 20% of its supply as Relenza®. This is due in part to product availability but also to the need to diversify the supply so as to not rely solely on one medication.

Many essential services (e.g., electricity, food, water, etc.) become scarce in the film's scenario. Could that happen?

An especially severe influenza pandemic could lead to high levels of illness, death, social disruption, and economic loss. Everyday life would be disrupted because so many people in so many places become seriously ill at the same time. Impacts can range from school and business closings to the interruption of basic services such as public transportation and food delivery.

In addition, a substantial percentage of the world's population will require some form of medical care. Health care facilities can be overwhelmed, creating a shortage of hospital staff, beds, ventilators and other supplies. Non-traditional sites such as schools may need to be used for patient care to cope with demand.

The film depicted many people who simply walked off their jobs. Would that really occur?

In a severe pandemic, it is very possible that up to 40% of a business' or organization's workforce will be out sick or at home taking care of sick family members. It is also possible that a small percentage of this amount will be people who are healthy but who may be too frightened to venture out into public.

The numbers of health-care workers and first responders available to work can be expected to be reduced as they will be at high risk of illness through exposure in the community and in health care settings, and some may have to miss work to care for ill family members.

What will be done with the overwhelming number of deceased bodies if we have a severe, 1918-like pandemic as was depicted in the film?

Addressing the possibility of a large number of deceased individuals in a pandemic is one of our top pandemic planning priorities. Currently, we are working on modeling studies to try to determine as clearly as we can what we could possibly expect in terms of numbers of deaths over the course of several pandemic waves. Until these studies are done, we won't be able to speculate on details of what we might or might not expect. We expect this work to be done in the next few months.

Regardless of whatever estimates are developed, it is highly unlikely that in the 21st Century in the U.S. that we would ever resort to mass graves. We are working with many government agencies (e.g., VA) as well as the private sector (e.g., the funeral industry, the cemetery industry) to develop guidance for states, local communities and others that maintains the dignity of the deceased, honors family wishes, and respects religious and social customs.

Deciding who gets vaccine was a major question in the film. In a real pandemic, how will you decide who gets vaccine first?

The greatest risk of hospitalization and death-as seen during the last two pandemics in 1957 and 1968 and during annual influenza-will be in infants, the elderly, and those with underlying health conditions. These individuals, along with health care providers, who are critical to maintaining a health care system in a pandemic, would likely be the first individuals to receive the first supplies of vaccine. However, in the 1918 pandemic, most deaths occurred in young adults, highlighting the need to remain flexible on determining priorities for vaccination groups based on the epidemiology of an emerging pandemic.

As part of planning efforts, two Federal advisory committees-the Advisory Committee on Immunization Practices and the National Vaccine Advisory Committee-have made recommendations for prioritizing critical populations that might receive the first supplies of vaccine. These recommendations can be found in the HHS Pandemic Plan, which is available at www.pandemicflu.gov.

In the movie, the Virginia governor's son dies because he cannot get diabetes medicine; other drugs are not available in pharmacies.

Essential supplies, including medicine, may become unavailable during a pandemic. As part of effective planning, individuals and families should talk to their doctor about how to maintain adequate access to prescription medications.
 

PCViking

Lutefisk Survivor
Poland

Ninth case of H5N1 bird flu virus in Poland

Published: 5/10/2006

WARSAW - Polish veterinary officials on Wednesday reported the country's ninth case of the highly pathogenic form of the H5N1 bird flu virus, which was detected last week in a wild swan in central Poland.

An observation zone with a 10-kilometer (6 mile) radius has been set up around the site in Warta where the infected dead swan was found, and poultry farms in the area have been checked by government health inspectors.

Poland reported its first case of the virulent H5N1 subtype of the bird flu virus in March.


05/10/2006 14:56 GMT

http://www.turkishpress.com/news.asp?id=122898
 

JPD

Inactive
Bird flu registered in Novosibirsk region, Siberia

http://www.itar-tass.com/eng/level2.html?NewsID=7918505&PageNum=0

10.05.2006, 19.59

MOSCOW, May 10 (Itar-Tass) - Bird flu has been registered in the Kochkovo district, the Novosibirsk region, Siberia, the head of the Russian agriculture watchdog, Sergei Dankvert, told.

“H5N1 virus has been found in non-vaccinated poultry in private households of the Reshety village,” he said.

So far the flu has killed 64 birds. The village has 35,000 poultry, Dankvert said.

Bird flu has been registered in Russia’s six villages, four of them in Dagestan, one – in the Krasnodar Territory and another one – in the Novosibirsk region.

As of May 5, 65.3 million doses of anti-bird flu vaccine was delivered to Russia’s regions. Almost 33 million birds were vaccinated all over Russia.
 

JPD

Inactive
Suspect Sumatra H5N1 Cluster Raises Pandemic Concerns

http://www.recombinomics.com/News/05100603/H5N1_Sumatra_Pandemic.html

Recombinomics Commentary
May 10, 2006

Last casualties who died were Ana Br Ginting, the woman was 29 years old, the citizen Street Veteran, Kabanjahe, the capital of the Karo Regency. He died around struck 05.00 WIB, during in the maintenance in the central Public Hospital (RSUP) Adam the Owner, Street Bungalow Medan.

Two casualties beforehand that died was Roy Karo-Karo, 19 years. He
Died on May 9 2006, now his mother Praise Br Ginting died last May 4. Both of them were expected strong terjangkit the bird flu virus.

Now casualties that still was treated at this time, numbering five people. Four people that was treated in isolation space of RSUP Adam the Owner, respectively Jones Ginting (25), Bonny Karo-karo (18) and Renaita Tarigan (1.8 years), as well as Obviously Ulina Ginting (8).

While Rafael Ginting, 8 years, was treated in RS Elisabeth, Street Imam Breakingprep Bonjol Medan.

The above detail on the suspected H5N1 bird flu fatalities raises additional pandmeic concerns. The mother died on May 4 followed the death of her son on May 9 and another family member on May 10. The delay of 5-10 days between the index case and family members is the hallmark of person-to-person transmission of H5N1. In Indonesia, as many as 2/3 of cases are linked to family clusters and the vast majority of the clusters have the 5-10 day gap.

However, in the past familial clusters were smaller, generally invoving 2 or 3 people. This cluster has 8 family members who have died or are hospitalized with bird flu symptoms, signaling a more efficient transmission of H5N1.

H5N1 has been present in Indonesia since 2003, but the first reported human cases were reported last year. If the current cluster is positive for H5N1, they will be the largest cluster in Indonesia and the largest confirmed cluster if all test positive.

In any event, the large number of family members, ranging in age from 40 to 1.5 and the differences in onset dates suggests this cluster is cause for concern.
 

JPD

Inactive
Indonesia, as above, per Dr. Niman's translation at the flu clinic, curevents:

http://www.mediaindo.co.id/berita.asp?id=99267

Medan -- MIOL: one patient suspect bird flu, Roy Karo-Karo, 19, villagers Kobu, Gulu Great, the Subdistrict three bows, the Karo Land Regency died, in the Public Hospital (RSU) Adam the Owner, Medan, on Tuesday (9/5).

Moreover, five people of his family that also was affected by bird flu were still being treated in the same hospital.They, Jones Ginting, 25, (the uncle), Bony Karo-Karo, 18, (the brother), Anta br Ginting, 29, (the aunt), Rafael Ginting, 8, (the cousin) and Renaita br Tarigan, 1,5, (the cousin).

Beforehand, on Thursday (4/6), the mother of casualties, Praise br Ginting, 40 also died in the same case in RS Elisabeth.

To six bird flu patients was brought by his family on Monday night (9/6), struck 23.30 WIB was based on reconciliation from RS Kabanjahe.They who were treated in space of the Longing isolation of A RS Adam this Owner experienced the same condition. That is the temperature of the high body, breathless and the cough.

Beforehand, was known by all these casualties mengonsumsi the piece chicken that was bought in the Kabanjahe Market.

Bidang Pelayanan Medis Deputy Director and Education, RS Adam the Owner, M. Nurasyid Lubis to the Indonesian Media said, the patient suffered breathless that difficult and the temperature of the high body.

According to Nurasyid, the sample of blood, the sample of the caress tengggorokan and the sample of the nose liquid from the patient at once was sent to the Centre of the Research and the Development of the Department of the Health in Jakarta.

Moreover, public relations RSU Adam the Owner of the Ginting rays said, the other patient still in the supervision of Tim Doctor RSU Adam the Owner that was chaired by Prof Luhur Suroso.

His development said he, continued to be supervised."They have been given the medicine that was connected with bird flu."

""In the meantime, casualties's grandmother, Manan br Sitepu, 86, looked very sad to experience this disaster.

"Very sad to see my extended family affected was sick that.

"It was not yet lost sad I because of my child die, currently my grandchild died."(YN/OL-02)."
 
Top