03/12 | Daily BF: Many farmers don't worry about chix roaming free... but, Gov't does

PCViking

Lutefisk Survivor
Link to yesterday's thread: http://www.timebomb2000.com/vb/showthread.php?t=189249

Since January, 2004 WHO has reported human cases of avian influenza A (H5N1) in the following countries:

* East Asia and the Pacific:
o Cambodia
o China
o Indonesia
o Thailand
o Vietnam

* Europe & Eurasia:
o Turkey

* Near East:
o Iraq
(see preliminary report)

Since December 2003, avian influenza A (H5N1) infections in poultry or wild birds have been reported in the following countries:

* Africa:
o Niger
o Nigeria

* East Asia & the Pacific:
o Cambodia
o China
o Hong Kong (SARPRC)
o Indonesia
o Japan
o Laos
o Malaysia
o Mongolia
o Thailand
o Vietnam

* Europe & Eurasia:
o Albania
o Austria
o Azerbaijan
o Bosnia & Herzegovina (H5)
o Bulgaria
o Croatia
o France
o Georgia (H5)
o Germany
o Greece
o Hungary
o Italy
o Poland
o Romania
o Russia
o Serbia and Montenegro (H5)
o Slovak Republic
o Slovenia
o Switzerland
o Turkey
o Ukraine

* Near East:
o Egypt
o Iraq (H5)
o Iran

* South Asia:
o India
o Kazakhstan
o Pakistan (H5)


For additional information about these reports, visit the
World Organization for Animal Health Web Site.

Updated March 10, 2006
http://www.cdc.gov/flu/avian/outbreaks/current.htm#animals

WHO, Avian Flu Timeline in .pdf: http://www.who.int/csr/disease/avian_influenza/timeline.pdf

:vik:
 

PCViking

Lutefisk Survivor
USA: Deleware

Backyard poultry farms on front line of flu fight

Many farmers in Delaware don't worry about chickens roaming free -- but the government does

By JENNIFER BROOKS
News Journal Washington Bureau
03/11/2006

If avian flu ever claims a human victim in Delaware, Frank Hetzell figures it'll be him.

"It could kill me," he says, "but I'm 70."

Hetzell raises exotic chickens on his spread at the dead-end of a road near St. Georges. Wild ducks and migrant geese mix with his birds, which pleases Hetzell, but scares the bejesus out of the federal government.

It's the U.S. Department of Agriculture's idea of a backyard biosecurity nightmare.

A lethal strain of avian influenza is spreading across Asia, Europe and Africa, killing birds and some humans who come in contact with them. As U.S health officials create worst-case scenario plans for the spread of the H5N1 bird flu virus to this country, small backyard flocks are coming under increased scrutiny.

Commercial poultry farms have been practicing biosecurity for decades. Their flocks are tested, vaccinated, screened and scrutinized and any diseases found are reported to state agriculture officials.

Backyard birds are another story. There is little regulation of the small poultry flocks that live scattered across the country.
In 2002, the National Agricultural Statistics Service counted some 1.3 million laying hens on 82,000 small farms with flocks of 50 or fewer chickens.

Since migratory birds appear to be carrying avian flu from one country to another, backyard birds may be far more vulnerable to the disease than commercial flocks that live most of their lives indoors.

http://www.delawareonline.com/apps/pbcs.dll/article?AID=/20060311/NEWS/603110316/1006

:vik:
 

PCViking

Lutefisk Survivor
WHO to train experts in human bird flu containment
Staff and agencies
10 March, 2006

By Stephanie Nebehay 15 minutes ago

GENEVA - The World Health Organization (WHO) said on Friday it would train a team of 100 experts in how contain an outbreak of the bird flu virus if it starts spreading easily between humans.

The United Nations agency has sent several dozen experts in the past two years to help Asian and Middle East countries treat H5N1 infections in people and shore up their defenses.

But the idea now is to give special training to a group of epidemiologists, laboratory and logistics experts worldwide in how to try to contain a highly contagious virus strain which could emerge -- before it sparks a deadly influenza pandemic.

"We will develop a roster of people who have received a great deal of training on containment procedures," Keiji Fukuda, acting director of the WHO‘s global influenza program, told a news briefing.

"We will initially try to train 100 people with a variety of skills," the American scientist added.

Bird flu has killed at least 96 people in Asia and the Middle East since late 2003. Scientists fear the virus, which has spread among birds in the last months to Europe and Africa, could mutate and spread easily from person to person, triggering a pandemic that could kill millions and cripple economies.

Fukuda was speaking after the WHO hosted three-day talks earlier this week among some 70 experts to sharpen the WHO‘s "rapid response and containment strategy."

Measures would include imposing quarantines and treating infected people and their contacts with Swiss firm Roche‘s antiviral Tamiflu -- all in a bid to halt transmission or at least slow the spread.

But the measures themselves raise difficult ethical issues, some of which remain unresolved, according to Fukuda.

"We made a great deal of progress on discussing some of these issues but it is quite complicated ... The whole idea of quarantine and containment is probably the biggest unresolved issue," he said.

"If, for example, you draw a big circle and say this is a quarantine zone, then issues come up. Do you keep people inside, do you keep people from the outside from moving in there, what kind of restrictions are there, what are the ethical considerations?" he said.

Solutions will vary on whether the pandemic strain emerges in a rural setting or large city, and there is "no single generic plan," according to Fukuda.

Roche has donated 3 million treatment courses of Tamiflu -- earmarked for use in the WHO‘s containment strategy -- and has pledged another 2 million courses by September.

"It is clear that if we try to contain a pandemic -- and this has never been attempted before, there is no precedent -- that there is a very good chance that we will fail, that we will not be able to stop it," Fukuda said.

"However, there is also a very good chance that if we mount this kind of effort we may slow down the spread of a pandemic virus early on. If we do that, if we buy some substantial amount of time and that means weeks, then we can really increase the chances for having more vaccine available more rapidly."

Each day gained following the detection of a pandemic virus would allow production of around 5 million doses of a pandemic vaccine -- which does not exist yet -- the WHO says.

Experts estimate it would take four to six months to develop a vaccine once a pandemic virus is identified.


http://www.heraldnewsdaily.com/stories/news-00155649.html

:vik:
 

ainitfunny

Saved, to glorify God.
Actually it is the POULTRY FACTORY FARMS that brought avian flu to AFRICA because they IMPORTED LIVE CHICKS AND FERTILE INCUBATOR EGGS FROM INFECTED NATIONS. It was THEY who gave avian flu to the small flocks. The concentrated viral load from a factory farm with tens or hundreds of thousands of infected animals can carry on the wind in concentrations sufficiently infective to endanger animals at very long distances where in contrast a few sick chickens in a backyard would not create a viral load on the wind sufficient to infect other poultry at much of any distance.
 

PCViking

Lutefisk Survivor
Avian flu worries change everyday life for Canadians living in Europe

MAUREEN MACNEILLSat Mar 11, 1:33 PM ET

VIENNA (CP) - More than just the winter cold is chilling the hearts of Canadians living in Europe now that worrisome cases of bird flu are cropping up close to home.

Avian influenza has mainly struck fowl and small mammals such as cats in central European countries so far. But it has created a sense of dread and foreboding among people worried that the deadly H5N1 virus could mutate into a form easily transmitted among people, giving rise to a pandemic.

Expatriate Canadians in affected European countries are feeling the impact on their daily lives, in small but sometimes very noticeable ways.

Seven-year-old Taia reacts with horror when she sees chicken or eggs on the table, crying out "bird flu" and refusing to eat them, says her father James Steward, a Vienna-based teacher from North Bay, Ont. There is no evidence suggesting the virus can survive thorough cooking.

Five-year-old Hannah Baumann doesn't get to spend her snack time outdoors in the pre-spring sunshine any more, not since two swans were found dead from bird flu in Austria last month.

Administrators of her Vienna preschool are worried about children coming into contact with contaminated feces of wild birds carrying the H5N1 virus, says her mother Barbara Gibson, who grew up in Saskatoon.


The preschool is close to the Danube River where there is an abundance of wild birds, including swans.

For some, the bird flu scare boils down to pricetags.

"Bird flu did affect me but in a silly way," says Greg Csullog from Deep River, Ont., who works for the International Atomic Energy Agency in Vienna. "I was worried that the culling of so many birds might increase the price of down duvets, so I purchased a new goose down duvet."

Others are preparing for the worst.

Joy Waldie of Toronto and her husband, Alain Giroux of Montreal, live in Geneva. A duck was found to have the H5N1 virus on Feb. 21 in Switzerland. Three dead swans initially suspected of having the virus later tested negative.

"Alain and I have had a good stockpile of food in the freezer since the first whispers of a pandemic went the rounds in the fall, but of late had become more relaxed about things," Waldie said. "However, it seems the subject is heating up again."

"If it breaks out, we aren't leaving the house," she said, adding she has enough frozen food and canned goods to last six weeks.

So far, the H5N1 virus has caused more than 95 human deaths in Asia and the Middle East. Almost all have been linked to close contact with fowl. When the virus first appeared in migrating birds in Europe around mid-October, people on the Continent started to pay a lot more attention to the threat it poses.

"I guess I am somewhere in the middle," Waldie says. "I think about it every day because it is on the news and I read about the latest developments, but I am less concerned about it than I was in the fall."

But it does have an effect on day-to-day life, she says,

Her five-year-old daughter Claire, for example, "came home from school on Friday and they had told the kids not to touch birds, feces or feathers."

One ladies' group she is in questioned whether it's a good idea to take the kids to the zoo. "When spring comes, we may avoid parks around the water ... anywhere swans go," she says.

Steward says his anxiety level is low, but he has upped precautions at home.

"No sunny-side-up eggs any more; they are thoroughly cooked," he says. "We try to keep chicken away from other food."

"We don't use a lot of precautions, but we have all started to think about it a lot more. When you're in a civilized country you think they will take care of you."


Kim Chan of Montreal says she is not very concerned about bird flu but it has become a house rule to wash the outside of eggs.

"We wash our hands a lot and carry disinfectant gel on the public transit" in Vienna, she says, adding the vigilance of the family against viruses is higher anyway because they have a seven-month-old baby.

"Personally I am concerned about bird flu, especially with the prospect of a human-to-human transmission before my return to Canada," says Csullog. "While the probability seems low, I'd hate to be stranded here when this job ends and unable to rejoin my previous workplace."

Steward says people in Vienna are thinking a lot about the issue.

"It seems pretty inevitable that the whole Earth will be struck by it in some way. I would feel less nervous in Canada."

Waldie says she is taking a wait-see attitude.

"We will see what the returning spring migration brings with it. I did consider trip cancellation (insurance) when I was booking my upcoming flights, but noticed in the small print that it didn't cover epidemics."

http://story.irishsun.com/p.x/ct/9/id/65c19ee9b40fa26b/cid/88176adfdf246af5/

:vik:
 

PCViking

Lutefisk Survivor
Azerbaijan

March 11, 2006]

New bird flu cases in Azerbaijan

(Assa-Irada Newsfeed Via Thomson Dialog NewsEdge)The fatal bird flu virus has been discovered on birds in the Gilazi poultry factory located in the north-western part of the Absheron peninsula. The infection was confirmed after tests conducted on blood samples taken last Wednesday from birds kept in the facility, according to the governmental commission set up to prevent the spread of the virus in Azerbaijan. A quarantine has been announced in the factory and surrounding areas and veterinary experts are currently at work on the site. The H5N1 strain was earlier detected on bird populations in the countrys southern Beylagan district bordering on Iran as well as the Caspian coast.

http://www.tmcnet.com/usubmit/2006/03/11/1449373.htm

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New Freedom

Veteran Member
http://www.thestar.com/NASApp/cs/Co...ageid=968332188492&col=968793972154&t=TS_Home

Bird flu targeting the young

As death toll nears 100, scientists scramble to explain why H5N1 virus is killing healthy people under 40
Mar. 11, 2006. 07:57 AM
RITA DALY
STAFF REPORTER

With the World Health Organization set to announce the 100th death from bird flu any day now, data compiled by the Toronto Star lead to one particularly compelling question: Why does the H5N1 virus attack the young?

The Star's analysis shows that all but six of the 97 people who have died globally so far from bird flu were under 40.

People, in other words, with the strongest immune systems and not, as one might expect, the elderly and those already sick. The median age was 19, and a quarter of them were under age 12.

Children, teenagers and young adults are the unfortunate victims of the deadly H5N1 bird flu sweeping through poultry farms in Asia, Africa and now Europe.

Hooked up to breathing tubes and dialysis machines in local hospital beds, bodies soaked in sweat, and blood oozing from their nostrils and mouth, they have a mere 50 per cent chance of pulling through. The rest die in a matter of days.

Any day now the World Health Organization will announce the 100th death from the bird flu that re-emerged in late 2003.

Yesterday, health officials confirmed a 4-year-old Indonesian boy died last month, bringing the number of confirmed cases to 176 and the world death toll to 97. Another three deaths in Azerbaijan are under investigation.

Although human cases are uncommon, it is now apparent the H5N1 will eventually reach North American shores, possibly via migratory birds in Alaska within six to 12 months. So what health experts know about how and whom it strikes is crucial.

So far, they know nearly everyone who died of the respiratory disease was in close contact with infected domestic birds, and most were young and previously healthy. Yet scientists still aren't sure why they fell ill, while others equally exposed to H5N1-infected chickens and ducks were spared.

"There are still a lot of unanswered questions and that's one of them," Sonja Olsen, an epidemiologist for the Atlanta-based U.S. Centers for Disease Control, said in an interview from Thailand where she is studying human cases of the H5N1.

There are other unanswered questions, like why is it some family members become infected and others not? Why aren't health-care workers in hospitals or unprotected agricultural workers slaughtering chickens also getting sick?

Originally surfacing in Hong Kong in 1997, killing six, then again in early 2003, killing one, the bird flu re-emerged later with a vengeance, decimating poultry stocks and infecting more people in areas of Southeast Asia.

The 97 deaths in the third wave are now spread across seven countries — Vietnam, Cambodia, Indonesia, China, Thailand, Turkey and Iraq. The infection rate is already double this year over last, with more than three human cases a week as infected birds spread the virus further afield.

"A lot of the human cases of bird flu have occurred in people under 25 and we're still not exactly sure why that is," said the WHO's Maria Cheng.

"They may have different behaviour patterns, they may be exposed to the virus in closer ways, they may be more susceptible to it. But there's such a small number of cases that it's difficult to draw any conclusions about how it's transmitted in target populations."

WHO officials stress the number of deaths from H5N1 bird flu is extremely low compared to the 250,000 to 500,000 who die annually from seasonal human flu, or the nearly 800 people who died during the SARS epidemic in 2003, 44 of them in Toronto. But health experts also warn no bird flu has ever sickened and killed so many people as H5N1.

The virus has only a limited ability to infect people, but experts fear it could mutate and spread easily among humans, sparking a pandemic that could kill millions within months.

Canadian officials have devised an emergency plan in the event of a pandemic, but say as long as H5N1 remains bird flu there is little cause for alarm in a country where people and poultry live separate lives.

In the past century we've had three human flu pandemics: in 1918, 1957 and 1968. The most lethal — the 1918 Spanish flu — also targeted the young and healthy, killing 20 million to 50 million worldwide.

In a study published in the online medical journal Respiratory Research in November, Hong Kong scientists noted the H5N1 was creating what's called a "cytokine storm" in its healthy victims, causing their immune system to overreact to the virus, flood the lungs with an overabundance of antibodies and cause extensive lung damage, eventually shutting them down. It's the same response scientists believe caused so many deaths during the Spanish flu.

The H5N1 virus has already earned the notorious reputation of being the worst flu in birds. An unprecedented 200 million have died or been slaughtered. It is so highly pathogenic, infected chickens drop dead in 48 hours. This month, the virus showed up in several domestic cats and a weasel-like animal called a stone marten in Germany and Austria, creating fear in the European Union that it might easily be infecting other species.

Earl Brown, an avian flu expert and professor of immunology and virology at the University of Ottawa, said the behaviour of small children playing among infected fowl could logically account for the high infection rate among the young.

A recent news report saw 15 Iraqi children running through an area where thousands of culled chickens were dumped, tying them to sticks and waving them in the air.

A 14-year-old Turkish boy and his two sisters, 15 and 11, died in January after playing with the head of an infected chicken the family slaughtered and ate. And an 8-year-old Turkish girl died after kissing and hugging her dying pet chicken.

But each person's immunity, even genetic factors, may also play a part in determining who falls ill and dies, Brown said.

"On average, you'll get influenza once every five or 10 years, so kids are less likely to have antibodies from prior exposure," he said. "Adults will have had experiences with different influenza viruses."

It still doesn't explain the disproportionate number of people in their 20s and 30s who have succumbed to the disease. One theory is that some people have immunity to the N1 antigen of the bird flu virus developed from the H1N1 Spanish flu. That virus was still circulating in a milder form until 1957 and also re-emerged as a milder strain in 1977.

Each time there is a suspected case, WHO officials quickly send a team of field experts to investigate.

Swab samples are sent to the organization's reference labs for further tests and to determine whether the virus has changed genetically in a way that might allow it to transmit more easily between people.

So far, they have found most confirmed cases involve people with backyard poultry farms who had close contact with infected or dying birds — in some cases slaughtering, defeathering and preparing them for dinner.

"When the chickens get sick and die, they get plucked, eviscerated and put into a pot, so maybe it's the mother and kids that are exposed at this point," Brown said.

Virologists know infection occurs through contact with blood, feces and other body fluids, and WHO officials recently reiterated the flu virus is also airborne, posing even a greater threat than AIDS.

If the virus were to start spreading easily among people, the first warning signal of a possible pandemic will be more and more clusters of people getting sick.

The CDC's Olsen and a team of researchers looked for this while examining 15 family clusters of infected cases in Vietnam, Thailand, Cambodia and Indonesia between Jan. 2004 and July 2005 — a mother and child; siblings; cousins; a niece and aunt; a teenager, her older brother and grandfather.

They found no increase over time.

But Olsen said most had not been investigated thoroughly enough to say for certain there was no person-to-person transmission.

"There was only one where you could clearly say there was person-to-person transmission and the others left you sort of wondering," she said.

WHO officials said this week there are three confirmed cases of suspected person-to-person transmission:

In January 2004, Ngo Le Hung, a 31-year-old Vietnamese schoolteacher, became infected and died from a chicken he bought for his wedding, and his two sisters also died.

In September 2004 a dying 11-year-old Sakuntala Premphasri infected her mother Pranee, 26, in Thailand and both died. And in July 2005 a 38-year-old father is believed to have infected his two daughters, aged one and eight — all three died.

Cheng said there may be other cases in which people became infected through human-to-human transmission, but there isn't enough evidence to prove it. There may also be many less severely ill people going unnoticed.

"But we haven't seen any substantial change in the virus and that is really the trigger we're watching for."
 

New Freedom

Veteran Member
http://www.voanews.com/english/2006-03-10-voa60.cfm

WHO Presents Plan to Contain Bird Flu Spread
By Lisa Schlein
Geneva
10 March 2006


The World Health Organization says it hopes to head off an avian flu pandemic by containing or slowing the disease in humans before the virus can spread. The U.N. Health Agency has presented details of a proposed new rapid response plan approved by 70 public health experts this week.

The new strategy aims to stop the transmission of bird flu from person to person should that become necessary. For this to happen, public health experts say it is critical to quickly identify a new influenza virus that can pass easily from person to person.

Presently, avian influenza is mostly an animal disease. Of the 175 people infected with the virus, 96 have died. All became sick after close contact with infected birds. The World Health Organization warns millions of people could die if the H5N1 virus in birds mutates into a form that could spread easily among humans.

WHO's Influenza Program Coordinator, Keiji Fukuda, says the new containment plan will try to stop a pandemic before it expands. He says containing a pandemic at its source has never been tried before. He adds there is a good chance the plan may fail.

"However, there is also a very good chance that if we mount this kind of effort, we may slow down the spread of a pandemic virus early on, and if we do that, if we buy some substantial amount of time - and that means weeks - then we can really increase the chances for having more vaccine available more rapidly,” said Dr. Fukuda. “It will give countries more time to prepare."

Public health experts attending a meeting in Geneva this week say there is evidence that suggests containment may work. They note the first outbreak of the avian influenza virus H5N1 was contained in Hong Kong in 1997. They say coordinated global action succeeded in stopping the emergence of severe acute respiratory syndrome or SARS in 2003.

Dr. Fukuda says the new strategy will involve different elements. He says specially trained health workers will be sent to areas where human to human transmission of the H5N1 virus is suspected. He says anti-viral drug supplies will have to be sent quickly where needed.

Dr. Fukuda says one of the biggest unresolved issues is that of quarantine and containment.

"So, if we have a situation where we have infected people, I think that there are certain measures that need to be put in place,” he said, “such as, putting the people who are infected in isolation, using anti-viral drugs for the people who are infected and then identifying those people who are in close contact to see whether they develop infection and so on. But, some of the unresolved issues are that if you do that kind of procedure, how would you do it in a rural setting? How would you do it in a large urban setting? How would you set the boundaries?"

Dr. Fukuda says it is not possible to predict where a pandemic might emerge. Therefore, people everywhere must be prepared. He says a single, generic plan cannot cover every country in the world. Dr. Fukuda says discussions to draw up plans tailored to each country situation will take place later in the year, beginning with currently affected countries.
emailme.gif
 

PCViking

Lutefisk Survivor
ainitfunny said:
Actually it is the POULTRY FACTORY FARMS that brought avian flu to AFRICA because they IMPORTED LIVE CHICKS AND FERTILE INCUBATOR EGGS FROM INFECTED NATIONS. It was THEY who gave avian flu to the small flocks. The concentrated viral load from a factory farm with tens or hundreds of thousands of infected animals can carry on the wind in concentrations sufficiently infective to endanger animals at very long distances where in contrast a few sick chickens in a backyard would not create a viral load on the wind sufficient to infect other poultry at much of any distance.

Yo AF... you Got It! Earlier this week one article in 'the daily thread' brought up the whole issue of poultry farms... IMHO, these GM (genetically mutated) chickens are bad news... and like the other GM products (from high-yeild sterile seeds, to mutated livestock) being forced on us these days, are just a time bomb ticking and waiting to blow. Whatever... there's a storm comin' and we better be smart and prep for it! Btw, if you have acerage, get some heirlom seeds, they'll be worth their weight in gold some day.

:vik:
 

JPD

Inactive
Bird Flu Reported in Cameroon, Fourth African Country, AFP Says

http://www.bloomberg.com/apps/news?pid=10000087&sid=ash0DgaOs6rc&refer=top_world_news

March 12 (Bloomberg) -- Bird flu was reported in a farmed duck in northern Cameroon, the fourth African nation to report an outbreak of the H5N1 virus, Agence France-Presse reported, citing a government statement.

Results of tests carried out in Paris on birds taken from the town of Maroua were positive for the H5N1 avian influenza virus, AFP reported yesterday.

Cameroon, which shares a 1,800-kilometer (1,119 miles) border with Nigeria, had already banned the import of birds from its neighbor after the discovery of bird flu there last month, the first such cases in Africa, the report said.

The virus was also discovered in Egypt and Niger last month. The discovery in Cameroon takes to 24 the number of countries worldwide to have reported initial avian-flu outbreaks since February.

(Agence France-Presse 3-11)
 

JPD

Inactive
Azerbaijan investigating possible family cluster of bird flu cases, WHO says

http://www.canada.com/topics/news/a...=eb8e2204-6c7c-4618-9638-1112fe45feb3&k=75559

Canadian Press
Published: Saturday, March 11, 2006

GENEVA (CP) - Health authorities in Azerbaijan are investigating a worrisome cluster of possible human cases of H5N1 avian influenza, the World Health Organization said Thursday.

A total of 11 suspected cases, including eight members of the same family, are being assessed, WHO spokeswoman Maria Cheng said.

Of the 11 suspect cases, three people have died and one is listed in serious condition in hospital.

"Currently there are signs that suggest this could be a human H5N1 cluster," Cheng said. "But we don't know that right now. We still need to do more thorough epidemiological investigation and wait for the lab results."

"It certainly looks a bit suspicious, but we don't have enough information to draw conclusions."

Though all human cases of avian flu are potentially dangerous, WHO pays particular attention to clusters of cases. While clusters may be the result of several people from the same family or village each having exposure to infected birds, they could also signal that the virus has passed from one person to another.

It is believed there have been a number of cases of limited human-to-human transmission of the H5N1 virus. But any sign of continued spread could mean the virus had mutated in ways that would allow it to more easily jump to and between people.

The possible cases in Azerbaijan have been reported in two villages, Sarvan and Daikend, in the eastern part of the country. They are near Baku, where that country's first reported H5N1 outbreaks in birds occurred.

Reports received by the WHO suggest some of the possible cases may have recovered and left hospital.

Cheng said specimens from the suspected cases, including the people who have died, will be sent to Britain's National Institute of Medical Research for testing. The North London lab is part of the WHO collaborating laboratory network.

Cheng said it wasn't yet clear if the samples could be sent Thursday. "We're waiting, I think, to see if they need more containers to ship the samples."

A three-member team from the WHO has been in Azerbaijan assisting local authorities with avian flu risk assessment and helping with the investigation. The team is made up of an epidemiologist, an infection control expert and a laboratory specialist.

Early indications suggest that at least some of the possible cases had a history of contact with poultry. And Cheng said it was known that there have been poultry outbreaks in this region.

"We know in that area there were sick and dying poultry and in neighbouring districts they had confirmed H5N1."

At present there has been no discussion of sending a larger WHO team to Azerbaijan, and authorities there have not asked the WHO for additional help.

"It hasn't been raised yet. Certainly we'd be prepared to do that if the country made that request," Cheng said.
 

PCViking

Lutefisk Survivor
Posted on Sun, Mar. 12, 2006
Experts warn of ventilator shortage if bird flu hits
DONALD G. McNEIL Jr.
New York Times News Service

No one knows whether an avian flu virus that is racing around the world might mutate into a strain that could cause a human pandemic, or whether such a pandemic would cause widespread illness in the United States. But if it did, public health experts and officials agree on one thing: The nation's hospitals would not have enough ventilators, the machines that pump oxygen into sick patients' lungs.

Right now, there are 105,000 ventilators, and even during a regular flu season, about 100,000 are in use. In a worst-case human pandemic, according to the national preparedness plan issued by President Bush in November, the country would need as many as 742,500.

To some experts, the ventilator shortage is the most glaring example of the country's lack of readiness for a pandemic.

"This is a life-or-death issue, and it reflects everything else that's wrong about our pandemic planning,"
said Dr. Irwin Redlener, director of the National Center for Disaster Preparedness at Columbia University. "The government puts out a 400-page plan, but we don't have any ventilators and there isn't much chance we're going to get them."

A typical hospital ventilator costs $30,000, and hospitals, operating on thin profit margins, say they cannot afford to buy and store hundreds of units that may never be used. Cheaper alternatives can be deployed in a crisis, but doctors say they are grossly inadequate to deal with a flu pandemic.

Congress authorized only $3.8 billion of the $7.1 billion that Bush requested for flu preparedness, and nearly 90 percent of it is earmarked for vaccines and the antiviral drug Tamiflu. Buying enough ventilators for a flu outbreak like that of 1918 would cost $18 billion.

"We only have a certain amount of money to spend on preparedness,"
said Thomas W. Skinner, a spokesman for the U.S. Centers for Disease Control and Prevention in Atlanta. "We can't invest strictly in respirators."

The federal preparedness plan leaves preparations for medical care up to state and city health officials, but the only government agency that amasses ventilators is the Strategic National Stockpile, created in 1999 by the disease centers to store medicine and equipment for use in a terrorist attack or a disaster. But the agency has only 4,000 to 5,000 ventilators, according to a federal official who spoke on the condition of anonymity because of a dispute between government health and security agencies about whether the size of the stockpile ought to be kept secret.


In a recent emergency drill, said Dr. John L. Hick, a professor of emergency medicine at the Mayo Medical School in Minnesota, the 27 hospitals in his area could come up with only 16 extra ventilators when faced with a hypothetical outbreak of 400 cases of pneumonic plague.

"In a pinch," Hick said, "you can hand-bag people," a procedure in which a fat plastic bellows is squeezed to push air into the lungs. "But in a pandemic, you're stuck."

In a national emergency, he said, "it will come down to some really thin cuts on a scoring system."

"Families are going to be told, 'We have to take your loved one off the ventilator even though, if we could keep him on it for a week, he might be fine,' " he went on. "How do you think that's going to go over? It's going to be a nightmare."

Representatives of three of the country's largest hospital chains, HCA, Tenet Healthcare and Triad Hospitals, said they were aware of the potential shortage. "We're considering the feasibility of acquiring additional ventilators, but I can't say we're even close to making that decision," said Jeff Prescott, a spokesman for HCA.

A few hospitals are stockpiling disposable emergency ventilators normally used by paramedics and powered by the pressure of the oxygen tank. Their plastic valves can be set to deliver oxygen at various pressures, and they cost $50 to $100 each. They can run for hours if attached to a large bedside tank, or indefinitely on a hospital's oxygen supply.

Mark Nunes, an emergency preparedness consultant to the Washington State Hospitals Association, said hospitals in the state had stockpiled about 1,500 of one brand, Vortran Automatic Resuscitators. But doctors said they required care to operate: too little pressure would not deliver enough oxygen to lungs made inflexible by fluid and mucus, while too much pressure could damage them, increasing the chances of fatal bacterial infections.

http://www.bradenton.com/mld/bradenton/news/local/14077365.htm

:vik:
 

PCViking

Lutefisk Survivor
NAIS

Bird flu spurs call for backyard biosecurity

By Jennifer Brooks
Gannett News Service March 12, 2006

HUME, Va. — A spring-like breeze is ruffling the branches of the persimmon trees on the Ussery homestead. The last of the winter vegetables is thriving in the greenhouse and the broody hens are softly clucking on their nests.

It's Harvey and Ellen Ussery's idea of heaven.

It's the U.S. Department of Agriculture's idea of a backyard biosecurity nightmare.

A lethal strain of avian influenza is spreading across Asia, Europe and Africa, killing birds and some humans who come in contact with them. As U.S health officials make worst-case scenario plans for the spread of the H5N1 bird flu virus to this country, small backyard flocks are coming under increased scrutiny.

Commercial poultry farms have been practicing biosecurity for decades. Their flocks are tested, vaccinated, screened and scrutinized and any diseases found are reported to state agriculture officials.

Backyard birds are another story. There is little regulation of the small poultry flocks that live scattered across the country. In 2002, the National Agricultural Statistics Service counted some 1.3 million laying hens on 82,000 small farms with flocks of 50 or fewer chickens.

Since migratory birds appear to be carrying avian flu from one country to another, backyard birds may be far more vulnerable to the disease than commercial flocks that live most of their lives indoors.

The agriculture department has begun an outreach campaign to backyard poultry farmers, urging them to step up biosecurity measures to keep themselves and their birds safe. Farmers are being told to call a toll-free hotline to report sick birds and to keep their birds securely fenced in.

The USDA is also in the early stages of creating a national database of every property with livestock, from large commercial operations to backyard 4-H projects.

The department's National Animal Identification System is voluntary at the moment, but registering with the government will likely be mandatory by 2008. Animals would be tagged and tracked.

So far, the effort has been met with mingled skepticism, exasperation and outright suspicion.

"We're not worried about avian influenza. What we're terrified about is the hysteria surrounding it," said Ussery, a retired postal worker who calls himself the Chicken Man of Hume. "The more paranoid among us think this is quite a deliberate ploy to get rid of backyard flocks."

In Asia, Europe and Africa, one of the first government responses to the bird flu outbreak was to ban backyard flocks in the infected regions.

In this country, outbreaks of mild avian influenza have led to widespread culling of domestic flocks. In 2004, Delaware and Maryland killed thousands of chickens after a handful of birds fell sick at three farms. After an outbreak in Virginia's Shenandoah Valley, agriculture officials ordered the destruction of 4 million turkeys.

USDA officials acknowledge their biosecurity outreach efforts are being resisted.

"There are privacy concerns and property concerns," said Fidelis Hegngi, senior staff veterinarian for the Animal and Plant Health Inspection Service. "There is no intention of the federal government to seize the birds. When we're dealing with a disease like this, our focus is on surveillance, surveillance, surveillance."

Ussery scoffs. He and his wife Ellen have worked for 22 years to turn their 2.5-acre farm into a homestead that produces almost all the food they eat. The 63 chickens, ducks, geese and guinea fowl on his property are key to his way of life and have never suffered a serious disease outbreak.

"They think we're backyard buffoons. They say we don't practice biosecurity," he said. "Our birds live the healthiest lives you could imagine. They eat healthy foods. I'm simply not worried about wild birds bringing in a microbe."

http://www.greenbaypressgazette.com...?AID=/20060312/GPG0101/603120708/1207/GPGnews

:vik:
 

JPD

Inactive
Wyoming, be ready for the flu

http://www.wyomingnews.com/news/more.asp?StoryID=107257

Gov. Dave Freudenthal and Michael Leavitt, U.S. secretary of health and human services, urged preparation at the Wyoming Pandemic Flu Summit.

By Jennifer Frazer
rep8@wyomingnews.com
Published in the Wyoming Tribune-Eagle

CHEYENNE - The governor of Wyoming and the U.S. secretary of Health and Human Services shared a united message at the Wyoming Pandemic Flu Summit Friday: Be prepared.

They would like this motto to be impressed on every mind and reflected in the pantries, medicine chests and supply closets of every Wyomingite.

It doesn't matter whether it is pandemic influenza, a blizzard or a bioterrorist or nuclear attack, said Secretary of Health and Human Services Michael Leavitt.

"What we're talking about here is preparedness," he said, "and preparedness saves lives."

Don't expect the federal government to help, he added, because it is going to be busy trying to help everyone at once.

"It needs to begin to permeate the thought process of the state that the notion of a pandemic is very different from what we're used to," Gov. Dave Freudenthal said.

Unlike the tornado in Wright or even Hurricane Katrina, he said, which were discrete events in specific areas, a pandemic creates a very different environment - one where many states are threatened at once, and the state next door won't be able to come to the rescue.

"In this context, there's going to be a much greater role for the public in terms of understanding and helping," he said.

In demonstration of their united cooperative effort, Freudenthal and Leavitt signed a planning agreement as a gesture of cooperation between the state and the federal government.

Also set aside in this year's state budget reserve account is $5 million for future flu pandemic needs, for which the governor thanked the Legislature.

In addition, the federal government has set aside some $350 million to help reduce the time needed for a flu vaccine to be manufactured for 300 million Americans to just six months from the current three to five years.

But even with an efficient vaccine delivery method, Americans will have to hold out for about six months.

Freudenthal and Leavitt encouraged stockpiling over a period of time.

"When you go to the store and buy three cans of tuna fish, buy a fourth and put it under the bed," he said. "When you go to the store to buy milk, buy powdered milk and put that under the bed."

People should try to accumulate up to a six-week supply of food, water, medicine and other essential supplies, he said. Preparation should be no different than that for a two-week blizzard.

"It's just a good idea," Leavitt said. "It's called self-reliance."

Leavitt highlighted what the potential human cost of such an outbreak might be. If a pandemic equal in magnitude to the 1918 flu epidemic struck today, he said, some 90 million people worldwide would be sickened, 40 million would seek hospitalization and 2 million would die.

And there is a candidate for such a pandemic - an avian flu, so far acquired only from birds, is flirting with human infection. So far it cannot be transmitted between people. But it has very similar genetics and virtually the same symptoms in people as the pandemic of 1918.

Admiral John Agwunobi, assistant secretary for health at the Department of Health and Human Services, showed a slide of an avian flu victim's lungs filled with pus, blood and fluid.

"The last time we saw this kind of damage was in 1918," he said, emphasizing that the current flu, unlike the 1918 virus, has not yet been able to spread person-to-person.

But there are costs beyond the loss of life itself. Leavitt noted how the economy of China was paralyzed after the relatively small SARS outbreak in which 8,000 people fell ill and 800 died.

Anne Alexander, director of the Health Economics Policy Center at the University of Wyoming, estimated the cost to Wyoming of a flu pandemic in medical and productivity costs at anywhere from $17.66 billion to $142.2 billion, in the event of an epidemic where 50 percent of those who contract the disease die.

Wyoming's rural nature may not necessarily protect it, either.

Freudenthal noted that Wyoming, though sparsely populated compared to other states, is right in the path of many migratory bird flight paths.

"Wyoming has as much chance of getting this as anyone," he said.

Leavitt concurred.

"If a pandemic happens in the 21st century, it'll happen in Wyoming. You can count on it," Leavitt said.

Such a pandemic, Leavitt said, would likely last 12 to 18 months and come in several waves lasting six to eight weeks each.

Planning efforts for such eventualities began in Wyoming more than a year ago.

Wyoming completed the latest version of its flu plan in January, but is seeking local input. The state also has created some 21 local emergency health planning and response coordinators whose job is to train, equip and plan for local public health emergencies.

But that is not enough, speakers said.

Every city, county, state, business, church, school and utility needs to have a plan, Freudenthal said, because the best way to fight a pandemic is on a local level.

What happens if 40 percent of the workforce can't come to work for six to eight weeks because they are sick, scared or caring for someone who's sick?

The best thing that local communities can do, Leavitt said, is to make a plan, consult planning checklists the government has made and have exercises to test the plan.

"It's one thing to have (plans)," he said, "It's another to get pills into the palms of people at the right moment."
 

PCViking

Lutefisk Survivor
Coming this spring

In another forum, a blog from the Wyoming Summit... quotes Leavitt saying that the bird flu will be here this spring.

My question is if there is a serious message... why go to Wyoming to tell it?

:vik:
 

Kim99

Veteran Member
A couple of posts from CE from personal doctors:

Jodi:

Interesting visit to the doctor by a friend.

I live in a small Indiana farm town. There is a small, county hospital just down the road from me. Some folks in town call it a band-aid station, but I figure it's better then nothing if you're having a heart attack or are in a bad accident. A lady I work with took her DH to the clinic accross from the hospital this morning. We use the same doctor. Her hubby had a really bad case of the flu.

While she was there, she took the opportunity to ask the doc about bird flu. He was very serious in his answers. He told her it's not going to be pretty. She asked if there was anything at all one could do. He told her to prepare for a quarentine and to also keep oneself as healthy as can be. If you smoke, quit. He also recommended to take Vitamin C and odor-free garlic everyday. While it won't keep you from catching it, he said it may help you survive it.

Her sister is a nurse at this small hospital and they have been having weekly meetings on BF. They have been discussing everything from getting healthier, to the fact the hospital does not have enough respirators to how and where to set up temporary morgues.

While it makes me feel a bit better to know the local health community in my little town is somewhat preparing, it raises my dread factor in the fact that this thing may be for real in coming.

One question for anyone who may know. Would it be beneficial to begin taking Vitamin C and garlic daily? I already take the C, but have never thought of garlic.

Thanks, Jodi
-----------------------------------------------------------------------------------------------------

Kris(MomCares):

I had an interesting chat with our family doc about bird flu at my physical last week.

I'd gently mentioned bird flu and asked about getting some extras on my regular prescriptions and also asked if he was prescribing Tamiflu (he said all doctors in our area had been told firmly NOT to prescribe it). In an attempt to keep him from thinking I was crazy, I lightly said, "Oh well, it probably won't happen anyways."

He looked at me really intently and said "It will happen, and the hospitals will instantly fill up." I could tell he is genuinely afraid, which was very sobering to me as he's a really level-headed and experienced doctor.

He gave me a Living Will form and strongly urged my DH and I both to fill them out ASAP.

Interesting.

Kris (MomCares)
 

JPD

Inactive
Myanmar tests dead birds for suspected bird flu

http://www.alertnet.org/thenews/newsdesk/SP237964.htm

By Aung Hla Tun

YANGON, March 12 (Reuters) - Myanmar authorities are testing scores of dead chickens and quails in the central Mandalay region to determine if they died from bird flu, industry and government officials said on Sunday.

If confirmed, it would be the first case of avian influenza in the secretive military-ruled country that is seen by some health experts as a black hole in the global fight against the disease.

"Over a week ago, a large number of chickens on some farms in Mandalay Division died of a disease very similar to bird flu," a poultry industry official in Mandalay told Reuters.

Authorities are testing for avian influenza and if confirmed, whether it is the H5N1 strain which has killed millions of birds and at least 97 people in Asia and the Middle East since 2003.

"We are taking all necessary measures to control the situation and to find out more accurate information about the disease," said a senior official at the Ministry of Livestock Breeding and Fisheries.

"We're still trying to know whether it was caused by H5N1 or not. We can't say anything for sure yet," the official, who declined to be identified, told Reuters.

Myanmar's junta promised last December to let the world know if bird flu spread to the country, which borders China, Thailand and Laos where outbreaks have already occurred.

Experts say it is only a matter of time before the virus arrives in the nation formerly called Burma, an increasingly isolated country ruled by the military since 1962.

They fear the virus will remain unreported -- either through lack of surveillance or a government cover-up -- long enough to mutate into a form that passes more easily between humans and trigger a pandemic that could kill millions.

However, Yangon has cooperated with U.N. agencies to step up surveillance in the countryside, including monitoring of prime stopover points for wild birds which could bring the virus from neighbouring countries.

The Yangon representative for the U.N. Food and Agriculture Organization (FAO) was unavailable for comment on Sunday.

Bird flu has killed at least 97 people in Asia and the Middle East since 2003. Victims contract the virus through close contact with infected poultry.
 

JPD

Inactive
FEATURE-US shippers face complex task in event of flu pandemic

http://today.reuters.com/investing/...45_RTRIDST_0_BIZFEATURE-BIRDFLU-TRANSPORT.XML

By Nick Carey

CHICAGO, March 12 (Reuters) - U.S. shipping companies, which play a vital economic role by moving trillions of dollars a year worth of goods between manufacturers and retailers, are busy making plans in case a dreaded bird flu pandemic hits the United States.

The companies, from air express providers to truckers to railroads, are focused on how they would function during a pandemic without spreading contagion in a business where human interaction is inevitable.

"We are on the front line," said Norman Black, spokesman for United Parcel Service Inc. (UPS.N: Quote, Profile, Research), the world's largest package delivery company.

The U.S. Bureau of Transportation Statistics said in a January 2006 report titled Freight in America that more than $1 out of every $10 in the U.S. gross domestic product (GDP) is related to transportation activity, including the movement of goods and the purchase of all transportation-related products and services.

Currently, the deadly H5N1 bird flu has killed 97 people, mostly in Southeast Asia. Turkey is only country in Europe to record any human deaths from the disease, which can be transmitted only by direct contact with infected birds.

But the growing number of infected birds found in Western Europe has raised fears the often-fatal disease could mutate into a form that could be easily transmitted between humans.

Health officials and scientists warn such a pandemic could infect millions within months.

"We have to balance our vital role of keeping the economy going with keeping our work force healthy," said Fletcher Hall, head of the American Trucking Associations influenza pandemic task force.

Because U.S. manufacturers and retailers increasingly rely on shipping companies to provide "just-in-time" goods to keep inventories low, even a small supply gap could have a severe impact on the economy.

"The increasing reliance on just-in-time practices means a disruption anywhere along the line could cause serious shortages for manufacturers and retailers," said Stephen Brown, a corporate finance director at rating agency Fitch Ratings.

"A regional outbreak would no longer be limited to that region, but would cascade into others as well," he added.

Although a pandemic remains theoretical for now, shippers say they have made contingency plans.

"They'd be foolish not to," said Jim Corridore, a transportation analyst at Standard & Poor's.

UPS and main rival FedEx Corp. (FDX.N: Quote, Profile, Research) said their global presence means they are already communicating with staff about risks and precautions. Both companies said most contingency plan details were confidential, but said they were relying on the World Health Organization and government guidelines.

"For now we are focusing on areas such as hygiene, and pass on recommendations such as regular hand washing to avoid contagion," said Sandra Munoz, FedEx's crisis communications manager.

Both FedEx and UPS said experiences with the outbreak of the deadly SARS virus in 2002 and 2003, which killed 774 people and caused worldwide panic, have helped with contingency plans for possible pandemics.

"We provided masks and gloves to staff and constantly updated them on the location of new cases," UPS's Black said.

During SARS, FedEx delivered medicine to affected areas, "so we have clear idea what to plan for with contagious diseases," Munoz said.

FedEx and UPS together ship more than 20 million packages daily.

PREPARATION, DRIVERS ARE KEY

Some railroads approach a possible pandemic like a natural disaster. Union Pacific Corp. (UNP.N: Quote, Profile, Research), the largest U.S. railroad, is working on contingency plans that are "not dissimilar to handling a major storm," said Robert Grimaila, vice president for safety, security and the environment.

"In the event medical first responders and our staff in a local community are incapacitated, we have plans to relocate both staff and resources," he added.

Although the railroads are working individually on pandemic contingency plans, the trucking association's task force is working on behalf of its 37,000 carrier members.

According to trucking association data, its members move more than 87 percent of all meat and poultry in the United States, but the group's task force leader said a human pandemic would be particularly bad for an industry already suffering from a driver shortage.

"We can't afford to lose more drivers," Hall said. "For that reason, I assume we are high on the U.S. government's list to receive antiviral drugs."

Transportation workers shipping fuel, water, food and medical suppliers are ranked second by the U.S. Department of Health and Human Services among population groups that would receive drugs in the event of a pandemic. The first tier, out of four, includes medical staff responders and workers manufacturing the antiviral drugs.

"The government considers transportation workers a high priority," said Jennifer Morcone, a press officer at the Centers for Disease Control and Prevention.
 

JPD

Inactive
Bird-flu fears grip eastern Laghman province

http://www.pajhwak.com/viewstory.asp?lng=eng&id=14827

MEHTARLAM, Mar 11 (Pajhwok Afghan News): The sudden death of a cat that ate a dead bird and several chickens has fueled fears of a possible bird-flu outbreak in the eastern Laghman province.

But the United Nations Food and Agriculture Organisation (FAO) moved quickly to downplay the concerns as premature. Ahead of laboratory tests of the samples, the FAO reasoned, it would be too early to say the virus had reached Laghman.

Mohammad Hussain Sapi, Laghman's agriculture director, Saturday told Pajhwok Afghan News that the death of the cat and fowls in Umerzai village was indicative of the avian-influenza virus.

In the neighbouring Nangarhar province, similar apprehensions recently led to the imposition of a ban on poultry sales and a cull of chickens. But the authorities concerned later found their apprehensions were not true.

Although there is no laboratory in Laghman to detect the disease, the director said, people's apprehensions were not altogether out of place. He linked the concerns to the abrupt death of 150 chicks in Mehtarlam, Daulat Shah and Alingar districts.

In a precautionary move, he added, the provincial government had placed restrictions on the poultry trade. Residents had been asked to refrain from the sale and purchase of chickens, continued Sapi, who argued precautions were necessary pending tests of chicken samples.

Mohammad Mustafa Sabri, a Laghman-based member of the commission dealing with the bird-flu problem, too suspected the cat and chickens had died of the virus. However, he explained the swabs of the roosters would be sent to Kabul for laboratory tests to get a definitive result.

In Kabul, FAO official Asadullah Azhari told this news agency they had sought the samples of the dead chickens for tests. The result would be known only after lab tests, he maintained.

mh/mud
 

JPD

Inactive
New bird flu outbreak detected

http://www.daily-news.ro/article_detail.php?idarticle=23808

Authorities said yesterday that preliminary tests on poultry in a southeastern town indicated infection by the H5 subtype of bird flu.
Cars passing through Cernavoda were being disinfected, Mayor Gheorghe Hansa said.

The preliminary tests were done by a mobile laboratory, and were being checked by a national lab in Bucharest which would also determine if the virus was the deadly H5N1 strain, he said.

If H5 is confirmed, Mayor Hansa said, the town of 20,000 would be quarantined. Results were expected today.

Romania has reported more than 40 clusters of H5N1 cases since the virus was first detected in October in the Danube River's delta, about 100 kilometers (60 miles) north of Cernavoda.
Authorities have culled more than 150,000 domestic birds as a precaution. No human cases have been reported in Romania.
Yesterday, animal health workers finished culling about 4,300 domestic birds in Harsova, in the Black Sea region. Parts of the town were under a strict quarantine, with people barred from entering or leaving the area except for emergencies.
Meanwhile, meat producers criticized the authorities for the measures taken to prevent the spread of bird flu, saying that local farmers register huge losses, while importers bring into the country meat at dumping prices. They said importers from U.S. and Brazil do not respect the European regulation regarding food safety, as certain chemical products they use to feed birds are banned in the European Union.

An AP transcript was also used for this report
 

JPD

Inactive
United States Selects Indonesian H5N1 for Pandemic Vaccine

http://www.recombinomics.com/News/03110601/H5N1_Pandemic_Vaccine_Indonesia.html

Recombinomics Commentary
March 11, 2006

The selection of a new pandemic vaccine candidate by the United States is not a surprise. When initial results of the first candidate vaccine was announced, it was clear that H5N1 was evolving away from that target, which was a 2004 isolate from Vietnam. The Qinghai version of H5N1 was spreading rapidly in Russia, Kazakhstan, and Mongolia, and further spread was anticipated.

However, an Indonesian strain has been selected as the next target. It is unlikely that a vaccine against an Indonesian isolate would offer significant protection for the Qinghai H5N1 strain of bird flu.

However, the specific examples an not publicly known. No human sequences from Indonesia have been made public. Similarly, no human isolates from China, Turkey, or Iran have been released to the public.. H5N1 is clearly evolving rapidly, suggesting several pandemic vaccines will be required because of the increasing number of genetically diverse strains that are causing fatal human infections.

In 2004 confirmed human cases were limited to Vietnam and Thailand and human isolates were closely related. Therefore a single vaccine would offer similar protection for H5N1 in Vietnam and Thailand.

However, in 2005 human cases were reported for Cambodia, Indonesia, and China. Although the Cambodian isolates were closely related to isolates from Vietnam and Thailand, Indonesian H5N1 isolates from poultry were distinct, as were isolates from poultry in China. There is also evidence that the Indonesian human sequences are different than the poultry sequences, especially in the HA cleavage site. Recent reports indicated that the cleavage site in a cat sequence from Indonesia matched the cleavage site in isolates from humans, but was distinct from the poultry isolates.

These differences bare a striking similarity to PB2 E627K. Prior to Qinghai Lake, all PB2 E627K isolates in H5N1 were in mammals. In the field, they were in humans, wild and domestic cats. At Qinghai Lake, all bird isolates did have E627K and all related sequences have had it since Qinghai Lake.

The same type of selection process may be happening in the HA cleavage site. However, there are no human sequences available from Indonesia or China for compaision.

Although WHO and consultants maintain that these small changes are due to random mutation, the evidence for recombination is overwhelming. The recent release of sequences from the 1970's and 80's clearly shows the movement of polymorphisms from North America to Asia via recombination.

The database for H5N1 sequences and other serotypes should be greatly expanded to identity donor sequences. The S227N sequence was generated via recombination with H9N2 donor sequences and the predicted G228S change also involves donor sequences from another serotype (H1N1 in European swine).

The existing database should be expanded with recent H5 isolates from Canada. The serotypes included H5N1, H5N2, H5N3, H5N9. These isolates will contain additional donor sequences for additional recombinations. The recent H5N1 Qinghai related sequences from Europe, the Middle East, Africa, and southern Asia should also be made available immediately.. The sequence contain important donor sequences that fuel H5N1 recombination and evolution. A more complete database of donor sequences will generate appropriate recombinant sequences for vaccine development.
 

JPD

Inactive
How Will Bird Flu Change Your Life?

A Look at What Could Happen at Home, Work, School and in Your Community

By ADRIENNE MAND LEWIN


March 12, 2006 — We've all heard the doomsday scenarios of what could happen if an avian flu pandemic takes a grip on the United States: millions dead, millions more sick, basic utilities and services unavailable, hospitals overrun and unable to cope, communities reduced to devastation like something out of Stephen King's "The Stand."

What's known is human-to-human transmission of bird flu is inevitable as HSN1, a type of bird-flu virus, mutates. "It's going to happen," said Dr. Joseph Agris, a Houston physician. "It's no question. It's just a question of when."

But what will actually occur in your life if there is a pandemic? Will you go to work? Will your kids stay home from school? How will your community services work if employees are sick? Is your local hospital prepared to deal with the influx of people who fall ill?

First of all, the virus may not be as intense in human cases in the United States as it has been elsewhere in the world because the flu in general tends to weaken as it reaches North America, said Agris, CEO of the Agris-Zindler Children's Foundation, which makes medical trips around the world to care for children.

"Right now what I'm seeing seems scary," he said, "but I think it's going to be less of a problem by the time it gets here than what is anticipated."

That doesn't mean, however, that an outbreak would be easy. "Even if you take the smallest number possible — 1 percent of the sickest portion of the U.S. population getting the disease — that's a million and a half people who'll either get sick or die," he added.

Even facing this threat, it is important to keep a sense of control, said David Ropeik, who teaches risk communication at the Harvard School of Public Health and who co-wrote "Risk: A Practical Guide for Deciding What's Really Safe and What's Really Dangerous in the World Around You."

"The risk you can't do anything about feels scarier than the one you can," Ropeik said. "Washing your hands a lot, sneezing into your elbow, knowing that avoiding crowded places if there's a flu epidemic of any kind, those are applicable. … They're emotionally reassuring in the face of some new threat. New threats are always scarier than ones we've lived with for a while. It's just their newness."

Getting Things Ready at Home

Best-case scenario: People abide by imposed quarantines, work from home if possible and ride out the course of the virus with minimal health problems.

Worst-case scenario: People are forced to stay home but fail to stock the necessary food and supplies and venture back out, catching bird flu and infecting their families.

According to health experts, there are basic steps that everyone should take to stay healthy, and they are the same as what you'd do to avoid any flu: Wash your hands often, don't shake hands with others, cover your mouth when coughing or sneezing, avoid crowds.

At the same time, you should stock up on essential items in case you get stuck at home for extended periods because of your own illness or quarantines.

"I think every person should have a little stockpile of food and water, a little bit like the air-raid shelters in the Cold War," said Arthur Caplan, director of the Center for Bioethics at the University of Pennsylvania. "The No. 1 strategy in protecting yourself from avian flu is to minimize contact with others."

Agris agreed, saying people should "stock up on a certain amount of basics — dried foods, pastas, extra canned goods, bottled water — a small amount of that will go a long way."

Caplan said people should also have a supply of high-quality HEPA, or high efficiency particulate air filter, masks and "a lot of soap — you have to wash your hands."

Businesses Brace for 'Global Blizzard'

Best-case scenario: People work from home when possible and business gets done while children and sick family members are cared for.

Worst-case scenario: Mildly symptomatic people go to work on mass transit, infecting other commuters and co-workers, which only intensifies the spread of bird flu. Businesses are crippled by mass illness and supply-chain disruptions. The nation's food supply is compromised.

Make no mistake: Dragging yourself to work with even a few flulike symptoms could be devastating to those who commute with you and work beside you. Experts said employers will have to cope with absencess because of illness, the need of their employees to care for others and their reluctance to ride mass transit. They also should put policies in place to prevent the spread of the virus at work.

Dr. Eric Toner, senior associate at the Center for Biosecurity at the University of Pittsburgh Medical Center, said that in addition to figuring out who could telecommute and how businesses could function on a reduced staff, companies should provide masks, cancel meetings and increase "social distance" to reduce transmission from person to person. They'll also need to reconsider sick leave policies.

"It's important not to have sick people coming to work," Toner said. "That's the worst thing possible. But what if people exceed their available sick time? For businesses that have contact with the public and their employees get sick, is that covered under workers compensation?"

Michael Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota, hosted a recent national summit for businesses on planning for pandemic flu. The discussion has begun, he said, but there's a long way to go for companies, as their response will help determine how the virus spreads.

"We have to look at this as a 12- to 18-month global blizzard," Osterholm said. "What companies are now beginning to realize is, even if they have business preparedness and continuity plans for other disasters, none of them have really been planned for addressing a pandemic."

Economic impact will be severe, he said. "Unfortunately, they understand today that they live in a global, just-in-time economy that has basically no surge capacity," Osterholm said, adding, "Part of that is due to the fact that much of planning depends on things beyond the organization — outsourced supply chains, transportation, utilities, any number of things like that."

Osterholm noted that 80 percent of all drugs in the country use raw ingredients that come from offshore, which will be hard to come by in a global pandemic. "Every country will be in it," he said. "Everything will be in really short supply at a pandemic and needed around the world."

Regarding employees' health, telecommuting is an option for some jobs but far from for all. "For many industries, you can't telecommute. You can't make steel or grow food at home," he said. "The second thing is, no one really knows for certain the actual capacity of the Internet system today if everybody were to use it for primary [communication]."

Agris said it will be important not to shut down the nation's transportation, or cities will not be able to get critical supplies. "You need to keep transportation open and keep those people healthy who handle the warehouses," he said.

Will Hospitals Help or Hinder?

Best-case scenario: Well-prepared hospitals have a stockpile of masks, gowns and gloves, as well as staff trained to manage an influx of patients and set priorities for the neediest cases, which will help keep the virus from spreading.

Worst-case scenario: Hospitals lack basic supplies and end up spreading the infection from unsanitary conditions rather than treating the sick.

The health care system's response to a pandemic will be crucial to how it plays out, experts said. But what happens if doctors and nurses panic and don't want to jeopardize their own health by treating others?

"Pay close attention to what happens to health care workers," Caplan said. "Get them in to work. They have to feel as safe as possible. … I'm very worried that since we've turned health care so much into a business, people will say, 'I'm just an employee. I'm not going to put myself at special risk.'"

And assuming they do come in to work, how many hospitals will be ready for mass illness? Toner said it would be tough to organize.

"Very few hospitals, if any, are well-prepared," Toner said. "No hospitals have adequate supplies of basic items to last through a pandemic. Nobody in modern business, particularly hospitals, have stockpiles of anything anymore because we have this just-in-time supply chain."

And that could prove to be deadly. "Hospitals not only will be unable to protect their staff and patients, they likely will become major amplifiers of the epidemic because the sick people will infect other people," he said. "If the pandemic is like 1918 or worse, which is possible, people won't be able to stay at home. This will be a life and death decision."

What about those who are uninsured or in the country illegally? Caplan said the health care industry must figure out who will pay to treat the sick.

"Insurance companies, managed care companies, HMOs — they have to make it clear that they're going to pull out the rules and people can get what they need, including illegal aliens," he said. "If we do have a pandemic, have an emphasis on getting to the doctor, not having people worried they're going to be deported."

For more information on how health care providers can prepare, click here.

Will Uncle Sam Help?

Best-case scenario: The federal government, already preparing, clearly communicates an action plan for a bird-flu pandemic. Local governments reach out to residents to provide resources, keep order and ensure calm prevails.

Worst-case scenario: Communities cannot provide essential services due to extensive employee illnesses, panic ensues.

Despite extensive preparations being made by the federal government in vaccine supplies and public education, there likely won't be much for it to do if a pandemic strikes.

"Once the pandemic starts, very little can be expected from the government," Toner said. "This is not meant to be critical of the government, but there's only so much that the government can do, and it can't do it in 5,000 communities at one time."

Perhaps its most important role will be providing information, Caplan said. "I think from the point of view of the government, they need to have some very clear and transparent rules in place so that the public understands what's going on," he said. "If they have to restrict your movement, if they have to quarantine people, why it's going on, that it's not permanent but will last a few weeks."

Caplan said such things as imposing a quarantine and determining how to ration masks would be difficult. "People are skeptical, too," he said. "because they watched the response to Katrina and they're not sure they can trust the authorities."

School's Out — For a While, at Least

Best-case scenario: Schools shut down for extended periods of time, saving the lives of many children, teachers and staff who could be infected in close quarters.

Worst-case scenario: Schools stay open, parents who must work send their children to school, hastening the spread of infection.

Experts said it is very likely that schools and day care centers will be shut down as soon as a pandemic begins. "They're incubators for infection," Caplan said.

But Toner said he is skeptical that it will be completely effective. "I'm not sure that it's the right thing to do, if for no other reason than a few weeks is not enough," he said.

But if you don't send kids to school, what are you going to do with them? "Most parents can't stay home to take care of kids," he said, "and if they do, they can't go to work. Most people need to work. Day care is worse. There are not any great options, but I think the school systems will decide to close."

For more information on how schools can prepare, click here.

Take a Deep Breath

In preparing for a bird-flu pandemic, two things are certain: Knowledge is good, panic is bad. But the more we know, the more frightened we tend to get, which doesn't help in the panic area.

"The more aware we are of a risk, the more afraid we are," said Ropeik, the risk expert. "Awareness will be up, and so will our worry, with the first bird in North America, and then just magnify that a zillionfold with the first human case in North America or the United States. And magnify that a zillionfold when word breaks out anywhere in the world should the mutation happen that allows it to become human to human."

Not to say bird flu is not scary — it just may not be as bad as we expect. "The two factors, newness and awareness, are characteristics of risk that make them seem scarier," he said. "Now sometimes they really are scarier and sometimes they aren't, but the fear bells will be hit with those — people will go to hospitals a lot more, rush to doctors for any kind of vaccine, the price of Tamiflu on eBay will go sky high and people's stress levels will rise."

And worrying, he said, can only make everything worse. "Stress suppresses your immune system," he said, "so the more worried you are about getting sick, the more likely it is that you will, or that your sickness will be worse or possibly fatal because your worry is making it harder for your immune system to protect itself."

His advice? Be prepared, but also be calm.

"Stay informed and try to keep things in perspective," he said, "so you don't stress out about any risk."
 

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Discovery of dead ducks heightens bird flu fears in Belgium

http://english.people.com.cn/200602/15/eng20060215_242952.html

Bird flu fears heightened in Belgium on Tuesday as several dozen dead ducks were found in a nature reserve in the East Flemish municipality of Lebbeke, expatica.com reported.

A hiker discovered the bodies of the ducks on Monday and fire brigade authorities cleared the area of the corpses on Tuesday.

Tests are being conducted to determine whether the ducks were infected with the bird flu virus. Experts from the Federal Food Agency have been dispatched to the area to determine the cause of the death.

However, due to the fact the birds were not migratory species, the chance of an infection with the dangerous H5N1 variant of the bird flu virus is small, said expatica.com.

The nature reserve has been closed to the public until the results of the tests are known.

Meanwhile, initial test results have indicated that a dead, domesticated swan found in the northeastern province of Limburg over the weekend was not infected with the avian flu virus.

Three dead geese were also found in the northwest city of Brugge.However, tests were not conducted on these birds because geese are less sensitive to the avian flu virus than wild swans.

The Federal Food Agency only conducts a test if five dead geese or ducks are found together.

An agency spokesman said the discovery of the dead ducks in Lebbeke showed that every dead water bird must be treated with caution.

However, he also said it is not rare to find dead birds during the winter months.

The heightened sense of vigilance in Belgium is due primarily to the fact that the bird flu virus has been confirmed in European Union (EU) states Greece and Italy.

It also appears likely that the virus has reached Austria, where two of the 21 dead birds found there in recent days were probably infected with the H5N1 strain dangerous to humans.

According to test results, there is a 70-percent chance that the H5N1 strain has reached Austria.

Consequently, Germany re-introduced a compulsory lock-up order for poultry on Monday and EU experts will decide later this week if the measures should be applied across the 25-nation bloc.

It had earlier been reported on Tuesday that Belgium was expected to re-introduce its compulsory lock-up order on March 1 in anticipation of the spring migratory season.

Source: Xinhua
 
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