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marsh

On TB every waking moment
Companies Plan to Boost Production of Controversial Malaria Drug as Demand Jumps
By
Josh Nathan-Kazis
March 24, 2020 9:57 am ET

Demand for hydroxychloroquine, the malaria drug that President Trump has touted as a treatment for Covid-19 despite limited evidence, has already begun to increase, according to a note from SVB Leerink analyst Ami Fadia.

Fadia wrote that 10.2 million hydroxychloroquine pills were sold in the week ending March 13, according to data-science company Iqvia, well above the average weekly volume of 8.5 million pills.

Approved for use to prevent malaria and to treat some auto-immunte diseases, hydroxychloroquine is manufactured by a number of generic-drug makers. In her note, Fadia outlined the plans of a number of the largest generic manufacturers to increase their output of hydroxychloroquine pills, though the sales wouldn’t have a substantial impact on the companies.

“Hydroxychloroquine [is] unlikely to be a financial driver,” Fadia wrote. “However, in light of the negative news flow generic companies have been besieged with over the past few years, from anticompetitive price increases to opioid litigation…the efforts by these companies to step-in and make a treatment available to help combat a pandemic would be a good reminder for various constituents of their importance to the health-care system.”

Excitement grew over the possibility that hydroxychloroquine could be an effective treatment for Covid-19, following the publication of a study by French researchers that suggested that hydroxychloroquine in combination with another drug had shortened the duration of Covid-19 infections. Experts warned that the study was small, wasn’t randomized, and was limited in other ways. But President Trump has trumpeted the drug, saying in a tweet that it has “a real chance to be one of the biggest game-changers in the history of medicine.”

At least five clinical trials are set to study hydroxychloroquine in Covid-19 patients, according to a note Sunday from Piper Sandler analyst David Amsellem. Experts say there is limited evidence, as yet, that the therapy is effective. Monday night, Evercore ISI analyst Umer Raffat distributed an abstract of an unpublished Chinese trial of hydroxychloroquine in patients with mild Covid-19 that appears to have had disappointing results. According to Raffat, the study found that 87% of patients on hydroxychloroquine experienced virological clearance by day 7, compared with 93% of patients in the control arm.

Still, generic manufacturers have already made commitments to ramp up production of hydroxychloroquine. In her note, Fadia wrote that Amneal Pharmaceuticals (AMRX) has said it will make 20 million pills by mid-April, Mylan (MYL) could provide 50 million pills using the ingredients it has available, Teva Pharmaceutical Industries (TEVA) will ship 6 million pills by the end of March and more than 10 million in total within a month. Novartis (NVS) subsidiary Sandoz has said it will donate 130 million doses if the drug is approved for Covid-19 patients, Fadia wrote.

All told, according to Fadia’s numbers, that would be enough doses for more than 6.7 million patients.

The increased demand measured by data available so far came before the publication of the French study, and could be attributable to other factors, such as stockpiling of pills by patients who use it for established treatments and are concerned about supply-chain issues during the epidemic. In the days since the president touted the drug as a possible cure for Covid-19, media reports have indicated a surge of sales of the drug. ProPublica reported that lupus patients who rely on the drug have had trouble filling their prescriptions.

In a note of caution, the Phoenix hospital system Banner Health said Monday evening that a man had died after apparently self-medicating with chloroquine phosphate, a chemical used to clean fish tanks that is different from hydroxychloroquine. Banner Health warned against any self medication for Covid-19.

For the companies planning to sell more hydroxychloroquine, the totals would be relatively small. The pills sell for 32 cents each, according to Fadia. She calculated that the sales for Mylan, for example, would be roughly $15 million. Teva’s sales would be roughly $3 million.
“Unless the market demand grows by an order of magnitude for an extended period of time (i.e., months), the financial implications are likely insignificant,” Fadia wrote.

But for a sector that has weathered damaging headlines associated with the opioid crisis and generic-drug price-fixing allegations, the benefits of helping to ease a global pandemic could go well beyond financial gain.

India BANS export of anti-malaria drug touted by Trump as potential Covid-19 cure
25 Mar, 2020 09:03 / Updated 1 day ago
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India BANS export of anti-malaria drug touted by Trump as potential Covid-19 cure


A policeman stands guard next to barricades during 21-day nationwide lockdown to limit the spreading of coronavirus disease (COVID-19), in New Delhi, India, March 25, 2020. © REUTERS/Danish Siddiqui

New Delhi has outlawed the export of hydroxychloroquine, an anti-malarial drug that some believe to be effective in treating coronavirus, save for certain exceptions. The drug has been talked up by US President Donald Trump.
The guidance for Indian companies to halt, without delay, the export of the medicine and its components came from the Indian Ministry of Commerce and Industry late Tuesday. The export ban appears to be a response to both a national and a global spike in demand for the drugs, after anecdotal evidence suggested they might be effective at fighting Covid-19, though the evidence is far from conclusive.

“The export of Hydroxychloroquine and formulations made from Hydroxychloroquine... is prohibited with immediate effect,” the ministry said.
READ MORE
India to go into COMPLETE lockdown from midnight – PM Modi India to go into COMPLETE lockdown from midnight – PM Modi

While the export of the drug has been halted with no end date in sight, deals that were already in progress when the notice was issued will be allowed to proceed.

Another exception is being made for humanitarian shipments that are, however, subject to approval by the Indian External Affairs Ministry and will be greenlit on a case-by-case basis.

The drugs in question, hydroxychloroquine as well as chloroquine, have long proven their effectiveness in treating malaria and other conditions.

However, both have been back in the news after Trump cited a novel survey indicating they can be effective in alleviating Covid-19 symptoms. While clinical trials of the drugs in the US have just started, Trump has drawn a huge backlash for touting “off-label” use of the medication as a possible breakthrough in treating the coronavirus.

India, which has so far managed to contain the outbreak with “only” 519 confirmed cases as opposed to a staggering 55,225 in the US, has rallied behind the drug. The Indian Council for Medical Research (ICMR) recommended prescribing it as preventive medication to those who come into contact with coronavirus patients.

“Hydroxy-chloroquine is found to be effective against coronavirus in laboratory studies and in-vivo studies,” the council, which leads the national Covid-19 task force, stated in its recent advisory, indicating that the country’s healthcare system may be bracing for an impending spike in cases.

However, in order to stop the spread of the virus, India is currently on a 21-day nationwide lockdown, which may stave off a major health crisis for the time being.
 

blueinterceptor

Veteran Member
Not trying to be silly or weird, this is an honest question ...

Most of the communications (in addition to isolation and such) is focusing in on not touching your eyes (nose, mouth, etc.); So, my question(s):
1.) Are those of you who wear contacts doing anything differently?
2.) Has anyone seen any correlating stats between those sick and contact wearers?

Just popped into my head, so I thought I'd ask.

HB

Constantly washing hands. Face. Wear rubber gloves. Glasses. Although I may switch to shooting glasses that wrap around
 

kenny1659

Veteran Member
While I understand the logic that they are using in this decision, I again have to ask, what the hell is wrong with the management of these hospitals and why in the hell haven't heads rolled for not stocking up months ago with the supplies that they would need when they saw how this virus was progressing in other parts of the world. I, not a lawyer, could make a pretty good argument that this is/was incompetence on part of the hospital administration, and therefore the hospital is liable, but I am sure we will see those type lawsuits in the coming days.
It's all about money. Stock cost money and they don't want to spend it.
 

Dobbin

Faithful Steed
It's all about money. Stock cost money and they don't want to spend it.
And stock has a shelf-life.

Owner uses N95 respirators when he's using the chipper-shredder. He recently broke open a new on his shelf box of N95s and found to his disappointment that the elastics on those masks are now "brittle", break, and won't hold the mask to his face.

"$20 down the tube" he said.

Dobbin
 

poppy

Veteran Member
They are still on lockdown until April 8th.


Yes they are. China did announce yesterday or the day before that they were going to start gradually opening up Wuhan and that is why activity has picked up a bit. I suspect they want to see if any new cases show up before opening it up all the way. There has been a lot of speculation about where all the missing folks in Wuhan are. They simply were locked down. China authorities are ruthless in enforcing their dictates and when they say stay home, the people know they had better stay home. Quite unlike here where many people consider these orders to be suggestions knowing there will be no consequences for not obeying.
 

20Gauge

TB Fanatic
Well they did it today. Businesses are to be closed today. No business but essential. Barbers, bars, and just about anything outside of hospitals, groceries and police are to be closed.

I am working alone, so I will stay open....

They are telling us it will be a $1000 fine and 60 days in jail, (at some point later in time) if we violate the rules.
 

20Gauge

TB Fanatic
Funny thing, there are no travel restrictions under the order. So it appears I can come into work, (legally), but can not have customers. As I can do a meet and greet with a drop off either by mail or email, I can keep things moving.

I just need to turn off the "open" sign and all should be good. LOL
 

Mixin

Veteran Member
Indiana, where its residents are denied the right to know:
Indy first responders track COVID-19 trends
by: Russ McQuaid
Posted: Mar 25, 2020 / 04:43 PM EDT / Updated: Mar 25, 2020 / 05:28 PM EDT
...
The Indiana State Department of Health reported that Marion County’s number of positive coronavirus test results doubled in 48 hours from Monday to Wednesday.

At 10 a.m. Monday, that total stood at 110, about the same time testing of at-risk health care workers showing COVID-19 symptoms began at Eli Lilly and Company.

Wednesday morning, the number was at 226 as more positive test results of individuals who were denied testing due to a lack of available kits last week are reported.

Indianapolis Emergency Medical Services personnel are also spotting an uptick in the number of people calling for ambulance service who are experiencing respiratory or influenza-like symptoms.

That total has climbed from 40 on Monday to 59 on Tuesday.

“What we’re seeing is what I think everyone would expect,” said IEMS Director Dr. Daniel O’Donnell. “We’re seeing an increase in the number of influenza-like illnesses and folks calling in with flu-like symptoms and calling us. Our overall volume remains constant, but we are seeing a higher percentage of those flu calls.”

Indiana State Health Commissioner Dr. Kristina Box told reporters at a statehouse briefing Wednesday afternoon that while ISDH has raw data on the number of Hoosiers testing positive for COVID-19 and deaths, demographic information regarding age and underlying medical issues remains elusive, though efforts are underway to confirm those statistics.

When pressed about the number of available intensive care hospital beds and ventilators throughout the state to treat the most seriously ill coronavirus patients, Dr. Box said that was a fluid number due to reconfigurations of bed space and the redeployment of essential equipment, and such statistics are kept confidential in an agreement with the reporting entities.

Dr. Box said that the state recently accepted its second disbursement of facemasks, face shields, n95 masks, gowns and gloves from the national strategic stockpile and that she was confident that Indiana medical care providers were well stocked for more than two weeks in anticipation of an expected coronavirus patient surge.
More:

********************************************
Another look at her refusal to disclose:
Indiana not detailing ICU capacity as coronavirus cases grow
...
Dr. Kristina Box, the state health commissioner, said during a news conference that state officials are keeping confidential information provided by hospitals about their intensive care unit capacity and equipment availability. She said she’s seeing “positive movements” in availability of ICU beds and ventilators.

“Because everybody is stepping up to the plate and trying to pretty much double their ICU capacity, I’m seeing those numbers increase as we go along,” Box said.

In contrast, Illinois officials have provided updates such as the number of occupied hospital beds and ventilators in use around the state and projections on what medical services will be needed if the virus outbreak isn’t contained.

 

Marthanoir

TB Fanatic
I'd mentioned this once, it's been awhile, so here again...

I've been building up my lung health for months with this...
View: https://www.youtube.com/watch?v=0pK0u3EAmG8


Panic Early, Beat the Rush!

- Shane
View attachment 188091


Cool, I use the Powerbreath variable resistance trainer

Plus-Light-Square.jpg


 

ginnie6

Veteran Member
A few more vehicles and pedestrians in Wuhan....

Where are the rest of the people?

Texican....

has anyone been reading the captions at the bottom of this video? One the other day cautioned against take out food as the virus may be transmitted that way. Just now it said the city is still on lockdown until April 8th. That may explain so little traffic or signs of life.
 

bsharp

Veteran Member
Taking a drug requires that you have medical support, either a doctor and/or a pharmacy able to supply. If you lack those, you have to consider the effect of cold-turkey withdrawal. When to taper (so as to minimize the system shock) is a personal decision. NOT to taper may be suicidal, depending on the drug. People need to study the situation and make their own decisions.

My doctor had me break my lisinopril tablets in half to wean off of them, while checking my BP regularly. Might be worth a phone call to ask if that might be a plan for you.
 

Hfcomms

EN66iq

Louisiana Church Continues Large Services Despite COVID-19 Safety Orders From Governor
By Frank CampDailyWire.com
Parishioners of the Lakewood Church led by Pastor Joel Osteen pray together during a service at the church as the city starts the process of rebuilding after severe flooding during Hurricane and Tropical Storm Harvey on September 3, 2017 in Houston, Texas.
Photo by Joe Raedle/Getty Images

On Sunday, Louisiana Governor John Bel Edwards issued a “Stay at Home” order prohibiting gatherings of more than ten people in an effort to curb the spread of COVID-19.

This order comes on the heels of two previous orders – one from March 13 that limited gatherings to 250 people or fewer, and one from March 16 that limited gatherings to 50 people or fewer.

Despite the orders from the governor, a church in Louisiana has continued to hold large services. On March 17, Life Tabernacle Church in Central, Louisiana, gathered for worship with more than 300 in attendance, according to Pastor Tony Spell.

Video footage of the Tuesday service posted on Facebook shows dozens of parishioners gathering near the stage, hugging and laying hands on each other. None appear to be wearing face masks or gloves.

During the service, Spell had ushers pass out “anointed clothes” to those in attendance, which he said would bring “healing virtue” and “the miraculous power of the Holy Ghost” with them.

A video posted to Facebook on March 17 shows Spell exiting the church and speaking briefly with a police officer outside. Although the audio of the exchange is too poor to understand, Spell spoke directly to the camera immediately after.

Spell told the cameraman:

Spell was asked by the man running the camera if he could be arrested. The pastor replied that he didn’t know, but added, “We’re taking persecution from friends, family, threat of lawsuits, threat of jail – nothing is gonna deter us from our religious conviction of worshipping and assembling and gathering.”

Despite what Spell claims the police officer told him, according to NBC affiliate WAFB, Louisiana National Guard Colonel Ed Bush said that the organization wouldn’t be enforcing gathering prohibitions. “The National Guard has not been tasked with enforcing any of the curfew, social distancing or meeting requirements as set by the governor,” Bush stated.

Additionally, Central Police Department Chief Roger Corcoran told CNN: “That was never told to the pastor by my officer.”

In a YouTube message on Thursday, Spell spoke about the biblical story of Shadrach, Meshach, and Abednego from the book of Daniel, then stated that the church wouldn’t be “in defiance of any codes, of any government mandates.”

Spell added that the buses bringing people to services would have no more than 50 people, and that the busses would be disinfected.

On Sunday, Life Tabernacle Church held services outside under tents. In a video posted to Facebook, a large number of parishioners can be seen worshiping, with only a few wearing basic surgical masks. Proper social distancing was not occurring.

Spell said COVID-19 doesn’t “concern” him, according to WAFB. “The virus, we believe, is politically motivated. We hold our religious rights dear and we are going to assemble no matter what someone says,” Spell reportedly stated.
WAFB notes that “East Baton Rouge Parish District Attorney Hillar Moore says those violating the governor’s proclamation could face prosecution as a last resort.”

In response to the continuation of the church’s large services, a petition has been launched to have Spell prosecuted for “reckless endangerment.” More than 6,000 people have signed.

As of Saturday, East Baton Rouge, Louisiana, has seen 75 confirmed cases of COVID-19, and three deaths, according to data from the Johns Hopkins Center for Systems Science and Engineering (CSSE) Global Cases map. The virus has infected more than 66,000 Americans, leading to 947 deaths.

The Daily Wire reached out to Central Police and Pastor Tony Spell for comment, but as of publication, we have not received a reply from either.
Governor Edwards’ March 22 order reads in part:



Governor Edwards’ previously issued order prohibiting public gatherings of more than 250 people included worship services.

When asked about the limit during a press conference, Edwards said: “This prohibition does apply to churches and houses of worship with congregations that exceed 250 in a single service. However, churches and places of worship can engage in multiple services and bring the number of people in them below 250.”
The governor explained his decision to include churches in the prohibition:

On March 16, when Governor Edwards announced further limitations on public gatherings to fewer than 50 people, he stated in part: “These limitations were difficult to make, but they are necessary to slow the spread of COVID-19, protect the health of Louisianans, and flatten the curve.”

Obviously they learned nothing from the church in South Korea that thought God was going to protect them. It was a Petri dish, many died and they spread the infection through the area. God doesn’t suffer fools very well especially when they have been warned.
 

Mixin

Veteran Member
The video states there are about 400 men housed at this facility

Wheeler Mission guest in Indianapolis tests positive for coronavirus
Posted: Mar 26, 2020 / 07:36 AM EDT / Updated: Mar 26, 2020 / 08:56 AM EDT

INDIANAPOLIS, Ind.-- A guest at the Wheeler Mission Ministries homeless shelter in Indianapolis tested positive for coronavirus, officials say. Steve Kerr, Executive VP of Advancement for Wheeler Mission, said they learned late Wednesday about the test results.

"The gentleman is not in our facility at this time and we are working on a plan that will be implemented first thing in the morning to dramatically reduce the number of men accessing our dayroom," said Kerr. "We believe at this time the Health Department is looking for an off-site facility where we can move many of our men to reduce this number - sort of divide and conquer."

Kerr said the guest was there for a few weeks and was asymptomatic. He wasn't feeling well and requested a test. The health department was contacted and took control. The guest was then transported to the hospital for treatment and went into isolation.

The news comes just one day after Wheeler Mission said on Facebook that social distancing is "just not possible" for them right now due to the number of people at their shelter.

 

bsharp

Veteran Member

Hfcomms

EN66iq
Not trying to be silly or weird, this is an honest question ...

Most of the communications (in addition to isolation and such) is focusing in on not touching your eyes (nose, mouth, etc.); So, my question(s):
1.) Are those of you who wear contacts doing anything differently?
2.) Has anyone seen any correlating stats between those sick and contact wearers?

Just popped into my head, so I thought I'd ask.

HB

Great observation. I don’t do anything different but I’m pretty anal about it anyway. I use daily disposable lenses so they are sterile. I was my hands well and let them air dry before I put the lenses in and do the same before I take them out.
 

Slydersan

Veteran Member
And stock has a shelf-life.

Owner uses N95 respirators when he's using the chipper-shredder. He recently broke open a new on his shelf box of N95s and found to his disappointment that the elastics on those masks are now "brittle", break, and won't hold the mask to his face.

"$20 down the tube" he said.

Dobbin

(edited for clarity) Staple a piece of twine or a new rubber band to the mask - the old elastic is NOT the important part...
 
Last edited:

Mixin

Veteran Member
There was only one confirmed case as of yesterday; we'll see if that county blows up in a couple of weeks.

Jackson County medical facility quarantines 63 employees

Sixty-three employees at a Jackson County medical facility have been placed in quarantine after coming in contact with an individual who has tested positive for COVID-19. Officials at Schneck Medical Center in Seymour said the employees have been placed on a 14-day quarantine because of their interaction with a patient who came into the facility for treatment but was not exhibiting any coronavirus symptoms.

Stephanie Furlow, director of marketing for Schneck, said the patient came into the facility during the early stages of the national outbreak and began to develop symptoms over time.

The impacted Schneck staff members initially were not wearing the proper protective equipment when treating or interacting with the patient, Furlow said.

While all of the employees have been placed on the standard 14-day quarantine, Furlow employees who show no symptoms may be allowed to return to work sooner. Those employees will be required to wear personal protective equipment at all times.

She added that the quarantine has not impacted staffing and the medical center is experiencing no shortages. “As we are limiting visitors in the hospital … we were able to redeploy those staff members into other areas,” she said.

 

poppy

Veteran Member
Funny thing, there are no travel restrictions under the order. So it appears I can come into work, (legally), but can not have customers. As I can do a meet and greet with a drop off either by mail or email, I can keep things moving.

I just need to turn off the "open" sign and all should be good. LOL

Pretty much that way everywhere I think. Hard to enact travel restrictions when people need to go out for things like food. I see no problem with people driving as long as it is your car and you don't being anyone but close family with you.
 

DunDunDuuun

GoGo Gadget Doom
So, have I missed something, or.... what's Russia doing? They've only got a handful of cases (that we know of) and I don't see anything about them in stories.
 

danielboon

TB Fanatic
Dispatch
Why Is Russia’s Coronavirus Case Count So Low?
Joshua Yaffa
March 25, 2020

A woman wearing a protective mask on a bus in Moscow,

As the coronavirus continues to spread, Russia may have a hard time tracking people who have caught it at work, on the metro, or from relatives.
Photograph by Evgenia Novozhenina / Reuters
In the past two weeks, I’ve observed from afar as various places around the world to which I have a personal attachment registered a grim uptick in coronavirus cases, and then, in response, effectively shut down. In Southern California, my mother was the first person I knew to self-quarantine; next were friends in Paris, who, in the span of forty-eight hours, went from eating lunch in cafés and planning a trip to Germany to hunkering down with their young children; then it was the turn of friends and colleagues in New York, where I lived for nearly a decade. During this time, Moscow, the city where I have lived for eight years, has felt like an unlikely outlier. Life here has definitely become stranger, but it is far from completely upended. As of Tuesday, Russia has four hundred and ninety-five official cases of covid-19, a small fraction of the number of cases in major European countries or in the United States.
Vladimir Putin has offered general assurances that the situation in Russia is “under control,” and, although Moscow’s mayor, a Putin loyalist, has closed schools and cancelled public events, the daily ebb and flow of the city hasn’t changed all that dramatically. I’ve mostly stayed at home, but the metro is still running, and shops and restaurants are open. The luxury department store Tsum is having one of its best years for sales in recent memory. Half my friends are observing some form of self-quarantine; the other half doesn’t get what the fuss is about—or, rather, their employers don’t.

It is unclear whether the Russian state has been lucky, smart with preëmptive measures, or dangerously incompetent—or some combination of all three. In the case of incompetence, Russia’s seemingly small figures will soon be replaced by colossal ones. In recent days, I’ve spoken to doctors, epidemiologists, and patients, to try and get a handle on whether Russia will be the next Italy, with an overwhelmed public-health system, or Japan, with its relatively flat and steady growth curve.
It is possible that, without having planned for it, Russian society, which is not nearly as defined by shoulder-to-shoulder public mixing as many European ones, had some advantages in weathering the early phase of the pandemic. Russia shares a twenty-six-hundred-mile border with China, but its most populous cities have fewer and less extensive ties with China than do many places in Europe. (Russian–Chinese trade topped a hundred billion dollars last year, but much of that came in oil and gas deliveries, a very different type of contact than one finds in, say, the many factories of northern Italy with a large Chinese labor force.) Russia is vast, with a relatively less developed transit infrastructure than European countries of similar populations. As a result, Michael Favorov, a doctor and public-health expert who previously oversaw C.D.C. programs in Eastern Europe and Central Asia, told me, “I wouldn’t expect a single outbreak in Russia but, rather, several, each with its own geography and developmental stages.”
It is also not impossible that Russia handled the early days of the pandemic with an admirable degree of foresight and care. In January, Russia shut down its land border with China. Beginning in February, passengers arriving to Moscow by plane from virus hot spots, such as China, Iran, and South Korea, were met by a phalanx of medical workers in protective gear administering tests. People who came from Europe—before those flights were cancelled—had their temperatures taken and were sent home for a mandatory fourteen-day quarantine. I talked to three people who developed symptoms while they were waiting at home for their test results, and who were put into isolation wards in a hospital in a Moscow suburb—a measure in line with recommendations from the World Health Organization to test and isolate. (I heard mixed reviews of this hospital, in the suburb of Kommunarka, which has become the city’s main coronavirus hub. One patient told me that he was “very impressed”; another complained that the swab she gave at the airport was lost and that she had to wait days to give another.) In theory, heavily policed authoritarian systems like Russia’s have a head start in tracking citizens—one man in Moscow, who had returned from Italy on the same plane as someone who later tested positive, was fined after cameras equipped with face-recognition technology caught him violating his mandatory quarantine by taking out the garbage. As I heard a political scientist acknowledge last week on Echo of Moscow, an independent, liberal radio station, “The fact that a certain regime is headed for a dead end in the long run doesn’t mean it may not have some advantages on the tactical level.” Melita Vujnovic, the W.H.O. representative in Moscow, recently told CNN, “Testing and identification of cases, tracing contacts, isolation—these are all measures that W.H.O. proposes and recommends, and they were in place all the time.”
As of this moment, Russia, a country of a hundred and forty-four million people, claims to have carried out a hundred and sixty-five thousand coronavirus tests in total, about half the number that were performed in the United States. Russia has fewer acknowledged cases than Luxembourg—and yet there is some evidence of a much larger outbreak of the coronavirus than the official statistics appear to suggest. According to Russia’s own statistics agency, the number of pneumonia cases in Moscow grew by thirty-seven per cent this January, compared with the same time last year. Anastasia Vasilyeva, the head of the independent Doctors Alliance trade union, said, “It’s impossible to know the real situation, but one thing we know for sure: the state is ready to manipulate medical statistics for political purposes.” In 2015, Putin announced a drive to lower the death rate from cardiovascular disease, after which hospitals reported a year-to-year drop in death from heart-related illness—and a nearly equivalent rise in deaths from rare or unclassifiable diseases. Similar manipulations may be at work now. On March 10th, a seventy-five-year-old man died at the hospital in Kommunarka. He had been undergoing chemotherapy treatment and recently returned from Italy. His cause of death was recorded as “adrenal hemorrhage”—meaning that his death was not formally attributed to the coronavirus. “We’ll never know the truth,” Vasilyeva said. “We can only assume.” On March 19th, a seventy-nine-year-old professor in Moscow died of pneumonia; initially, Russian officials linked her cause of death to the coronavirus, but later changed it to “blood clot.”
In recent days, stories about wards overflowing with pneumonia patients have circulated on Russian social media. As Vasiliy Vlassov, an epidemiologist and professor at the Higher School of Economics, in Moscow, pointed out, even if there is nothing to suggest that Russia is covering up a much wider outbreak, the country’s infection curve is just beginning. “For now, we’re way over on the left,” he said. “The question is, as it builds out to the right, will the curve be linear or exponential?” Vlassov also noted that, although official case numbers remain relatively low, they are growing at an alarming rate, doubling every two days, compared with every three or more days in Europe. Vlassov also explained that Russia has recently begun to use a more sensitive test and is allowing testing to be carried out by a larger number of laboratories around the country; the upward curve may therefore reflect not only new cases but the true scale of already existing ones. Increasingly, public figures are suggesting that Russia’s official count is likely too low. Moscow’s mayor, who is leading Russia’s response to the coronavirus, told Putin on Tuesday, “Nobody knows the real picture. In reality, there are far more people who are infected.”
As the epidemic continues to spread, Russia may have a harder time tracking people who have caught the coronavirus at work, on the metro, or from relatives. Sergey Netesov, the head of the bionanotechnology, microbiology, and virology laboratory at Novosibirsk State University, who was previously a researcher at Vector—the state laboratory that developed the first coronavirus test in Russia—told me, “These are the most dangerous carriers, and I’m worried this contingent is not being caught at all, at least not yet.” For every story I heard that suggested a thorough, even overly paranoid, approach—one friend told me of his neighbor who was tested after other residents in their building heard her repeatedly coughing in the stairwell and called the city’s coronavirus hotline—I heard another story that conveyed a less encouraging image, such as that of a nineteen-year-old college student in Moscow who was refused a test, despite experiencing a fever and a persistent cough, even after her university dorm was closed for fear of coronavirus infection. I spoke to a man in Volgograd, a city in southern Russia, who told me that he had come down with pneumonia late last month. At the hospital, doctors told him that rates of pneumonia in the city were ten times higher than in previous years—every second or third patient seemed to be suffering from the ailment, they said. “I couldn’t stop coughing,” the man told me. “I was running out of breath every hundred metres—it reminded me of what I’d heard everyone talking about.” Doctors asked him whether he’d been in contact with anyone who had recently been in China or Europe—as far as he knew, he hadn’t—but they didn’t test him for the coronavirus. Stories like this, Vasilyeva said, may suggest either a purposeful coverup or simply a lack of know-how, equipment, and testing abilities, especially in smaller cities and more far-flung regions.
Russia has a higher number of ventilators per capita than many Western countries, which suggests that the country may not be in the worst position as the outbreak spreads. At the same time, according to numerous reports in the Russian press, doctors around the country are worried about a lack of training in how to deal with suspected coronavirus patients, and about a deficit of basic supplies, including masks and gloves. Higher up the chain, Russia’s bureaucracy tends to favor obedience and loyalty over competence. The first covid-19 patient in the Stavropol region turned out to be its chief infectious-diseases doctor, who’d ignored quarantine requirements after her return from Spain earlier this month. She visited several hospitals and taught numerous classes at the local medical university before coming down with symptoms and testing positive for the virus. As for the public at large, I’ve observed a kind of weary exhaustion among many Russians toward the state. The country has so many strict and redundant laws, in which the insignificant is made equal with the significant, that outsmarting or ignoring them is an understandable response. That may make it hard for the state to act with credibility and impact as it introduces measures meant to protect the population.
Lurking in the background, as infection numbers rise, is the question of the constitutional referendum scheduled for April 22nd. As I wrote earlier this month, this anodyne-sounding vote is really meant to allow Putin to run for a fifth, and possibly a sixth, term. The Kremlin wanted little fuss around the referendum, but the coronavirus is now complicating things. If infections climb exponentially, public voting will look more and more like madness, which is why the Kremlin has begun suggesting that the vote could be held in June. The Kremlin has also hinted that it may expand at-home voting, which sounds sensible, except for the fact that such a vote would be even more susceptible to fraud and manipulation than a normal Russian election. As with the facial-recognition technology deployed to find quarantine violators, such innovations, ostensibly meant to deal with the coronavirus, may well become regular features of monitoring and controlling public life in years to come.
I’ve spent the last days waiting for news of whether, as the case count steadily grows, Moscow will be put under general quarantine. Perhaps Putin will wait to enforce such a measure until after he gets the constitutional stamp he needs to extend his rule by another decade or more. The sudden drop in oil prices this month and the subsequent fall of the ruble will likely push Russia into recession; a widespread lockdown could produce further economic pain, which the Kremlin would consider even more politically costly than a worsening epidemic. What’s clear is that Russia’s response to covid-19 is inexorably bound up with the political needs of the moment—and, as Vlassov told me, that as the government weighs what comes.
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NHGUNNER

Senior Member
Sorry if posted earlier. I haven't been able to keep up.

Jack Allard, former Bates All-American battling COVID-19, moves closer to experimental treatment
The 25-year-old Bates College graduate has been cleared to receive an experimental drug but remains in a coma and on a ventilator.

LEWISTON — A Bates College graduate who has made national news after contracting COVID-19 took what members of the school’s lacrosse program hope is a critical step in his recovery Wednesday.

According to Bates men’s lacrosse coach Peter Lasagna, it is hoped that Allard can soon begin receiving Remdesivir, an experimental drug produced by Gilead Sciences Inc. On Wednesday afternoon, Genny Allard, Jack’s mother, sent a message to Lasagna and others expressing great confidence in the treatment he’s receiving in Philadelphia. “Jack’s oxygen levels continue to improve,” Lasagna said. “If his liver function numbers get better he could start the new drugs (Thursday).”
Allard, a 2016 Bates graduate, remains in critical condition. He is in a medically-induced coma and breathing with the help of a ventilator. But getting him into the trial helped alleviate some of the frustration and anxiety his family and friends are experiencing, first with getting Allard diagnosed, then with getting him access to the experimental drug. Allard became ill on March 13 with symptoms that included vomiting, back pain and fever. A native of Ridgewood, New Jersey, Allard was working as an associate of Bank of America in Manhattan when he fell ill. He had not traveled outside of the country recently and did not have a cough before the other symptoms emerged.

He checked himself into the hospital on March 15 and was tested the next day for COVID-19 but the lab handling the test lost it, according to The Daily Voice, a newspaper in Ridgewood. As Allard’s condition worsened, his family became convinced that he had the coronavirus and began exploring options to have him treated as soon as possible, once a second test confirmed it. The Daily Voice reported that five days later, Allard was given a second test, which came back positive. “That was devastating to the family, obviously,” Lasagna said. “But once he got that positive test they could get back to working on getting him into a clinical trial (for Remdesivir).”

“Their case was here’s a young, healthy 25-year-old with no pre-existing medical conditions. If there was anyone you wanted in your trial to find out if it works, he was it,” Lasagna said. Doctors requested the drug on Allard’s behalf on Saturday. But citing overwhelming demand for Remdesivir, Gilead announced on Sunday that it would be limiting the drug’s availability to “individual compassionate requests” from pregnant women and children under 18. Allard’s family enlisted the help of a local congressman to lobby the company to make an exception for Allard, and they learned Tuesday that his request had been approved. Doctors hope the drug, which had previously been tested on Ebola, SARS and MERS viruses, will slow the virus and allow Allard’s immune system to battle it. “His doctors say this is something that can really help him,” Genny Allard said in an interview on Fox News Network on Tuesday night. “We really think this is the best chance he has to survive it.” Allard was transferred to the hospital in Pennsylvania because it was a critical care facility with the capability of providing an “extracorporeal membrane oxygenation” (ECMO) machine, which Genny Allard said her son may need as part of his treatment. “ECMO was explained to me as a kind of dialysis for your lungs,” she said in the interview.

Jack Allard, former Bates All-American battling COVID-19, moves closer to experimental treatment
 

CaryC

Has No Life - Lives on TB
And stock has a shelf-life.

Owner uses N95 respirators when he's using the chipper-shredder. He recently broke open a new on his shelf box of N95s and found to his disappointment that the elastics on those masks are now "brittle", break, and won't hold the mask to his face.

"$20 down the tube" he said.

Dobbin

Wait holler …… yell......neeee at owner, quick. Tell him that's what duck tape is for. Seriously a little paracord will fix that up nicely.
 

bsharp

Veteran Member
And stock has a shelf-life.

Owner uses N95 respirators when he's using the chipper-shredder. He recently broke open a new on his shelf box of N95s and found to his disappointment that the elastics on those masks are now "brittle", break, and won't hold the mask to his face.

"$20 down the tube" he said.

Dobbin
The mask is still good, just replace the elastic!
 

oleglass

Contributing Member
Hmmm.......... What, is Bayer making all the tests for them?

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San Fran:

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Just talked this morning to grandson on active duty (Army) in South Korea and he said they have several activ duty personnel in lockdown for th virus.
They are monitoring this very closely, so it can be contained.
 

20Gauge

TB Fanatic
And stock has a shelf-life.

Owner uses N95 respirators when he's using the chipper-shredder. He recently broke open a new on his shelf box of N95s and found to his disappointment that the elastics on those masks are now "brittle", break, and won't hold the mask to his face.

"$20 down the tube" he said.

Dobbin
Staple some rubber bands on it.... make it work....
 
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