CORONA Main Coronavirus thread

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View: https://www.youtube.com/watch?v=786kiTxg6Bk
TWiV 914: COVID-19 clinical update #121 with Dr. Daniel Griffin
37 min 49 sec
Jul 2, 2022
Vincent Racaniello


In COVID-19 clinical update #121, Dr. Griffin discusses age as a risk factor for severe disease, updated vaccine boosters for the fall, pediatric infection and antibody seroprevalence in Arkansas over the first year of the COVID-19 pandemic, all-cause maternal mortality in the United States before and during the pandemic, and the effect of 2-week interruption in methotrexate treatment and how it impacts vaccine immunity. Show notes at https://www.microbe.tv/twiv/twiv-914/
 

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View: https://www.youtube.com/watch?v=dmFpxWWidFQ
Reduced Risk of Long COVID from Omicron As Compared to Delta
27 min 50 sec
Streamed live 6 hours ago
Drbeen Medical Lectures


Reduced Risk of Long COVID from Omicron As Compared to Delta Zoe app study printed in the Lancet demonstrates that in some cases the risk of long COVID in the Omicron era is 76% lesser than the long COVID in the Delta era. Let's review the data. If you like this content and want more, I am doing a special lifetime membership offer. Click here: https://www.drbeen.com/yt-special/



View: https://www.youtube.com/watch?v=RUD8rJCz_Ho
Llama's May Protect from COVID-19 (Study from Mt. Sinai Hospital)
19 min 32 sec
Streamed live on Jun 30, 2022
Drbeen Medical Lectures


Llama's Blood May Protect from COVID-19 The work involved a team at Mount Sinai Hospital in New York and a llama named Wally. If you like this content and want more, I am doing a special lifetime membership offer. Click here: https://www.drbeen.com/yt-special/
 

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Deadline passes and 1 in 10 Army National Guard soldiers still unvaccinated for Covid. Will they be expelled?
Courtney Kube - NBC News
Fri, July 1, 2022, 7:42 AM

The deadline for all Army National Guard soldiers to be vaccinated for Covid passed at midnight, with about a tenth of the 330,000 soldiers still unvaccinated and subject to financial penalties or potential future expulsion.

Defense officials said earlier this week, however, that amid the Guard's recruiting crisis, there were already signs that unit commanders may be allowed to let unvaccinated troops continue receiving pay and benefits for some period. On Friday, the Army announced a way for commanders to keep unvaccinated soldiers on limited duty.

In November, Secretary of Defense Lloyd Austin directed that members of the Army National Guard and the Air National Guard who were unvaccinated by the deadline would be unable to participate in drills, get paid or put their service days toward their retirement. Their continued refusal could result in "separation," or expulsion from the service.

About 14,000 members of the Army Guard had explicitly refused to be vaccinated, but new figures released by the Army show that number has dropped to under 12,000. Another 7,000 have requested exemptions, many for religious reasons, the officials said.

Prior to publication of this article, the Army did not answer questions about whether it would enforce the threat of separation. On Friday afternoon, the Army released a statement saying it will begin enforcing the mandate, and that “soldiers who refuse the vaccination order without an approved or pending exemption request are subject to adverse administrative actions, including flags, bars to service, and official reprimands. In the future, Soldiers who continue to refuse the vaccination order without an exemption may be subject to additional adverse administrative action, including separation.”

On Monday, NBC News reported that every branch of the U.S. military is struggling to meet its 2022 recruiting goals.

As of June 27, 86.4% of Army Guard soldiers were fully vaccinated and 88.59% had received at least one dose of the vaccine. The Army Guard has about 330,000 total members, meaning that more than 37,000 had not been vaccinated as of Monday.

After publication, the Army released new figures for total vaccinations, showing the Army Guard is at 87% fully vaccinated and 89% vaccinated with one dose. The Army Reserve is at 88% fully vaccinated and 89% with one dose. It is also scheduled to begin enforcing the vaccination requirement Friday.

Earlier this week, defense officials said that because of the fear of losing troops in a bad year for recruiting, individual unit commanders might be allowed to put unvaccinated troops in a temporary status that would let them keep their pay and benefits longer.

On Friday afternoon, the Army announced that unit commanders will be able to activate and pay soldiers for limited administrative purposes, such as receiving the vaccine, processing their exemption requests or conducting separation procedures. Soldiers will be paid and/or receive retirement credit for these service days.

The officials say that if the unvaccinated troops have requested an exemption, have begun vaccination but not entered their information into the military's electronic health record, or if they are being processed for separation, commanders can assign them to a temporary duty status that allows them to be paid and earn retirement credit, potentially for months, while they complete their administrative processes.

Overall, about 90% of the total 435,000 National Guard service members — both the Air Guard and the Army Guard — are now vaccinated, according to National Guard officials. About 94% of the Air Guard members are vaccinated.
Defense officials are hopeful some of the more than 37,000 Army Guard holdouts will get their vaccine and not be forced out.

“We’re going to give every soldier every opportunity to get vaccinated and continue their military career,” said Lt. Gen. Jon Jensen, director of the Army Guard. “We’re not giving up on anybody until the separation paperwork is signed and completed.”

To date, no Army Guard or Army Reserve soldiers have been separated for refusing the vaccine.
 

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Army says National Guard, reservists will now be subject to vaccine mandate
The National Guard and Reserve forces vaccine deadline was this week.
By Sophie Mann
Updated: July 1, 2022 - 3:08pm

The Army announced Friday that members of the National Guard and Reserve forces will have to be in compliance with its COVID-19 vaccine mandate to take part in drills.

The service said members who are not in compliance without an approved or pending exemption cannot participate in federally funded training and will not receive payment or retirement credit.

The Army National Guard's vaccine deadline was on Thursday.

Secretary of State Lloyd Austin mandated vaccinations for the military in August 2021 but allowed each service branch to set its own deadlines. The deadline for active-component Army personnel was December 15, but reservists and National Guard members were given until June 30.

The service approves on a case-by-case basis exemption requests for medical or religious reasons. In its statement, the Army stated members who refuse the order without an approved or pending exemption will be subject to "adverse administrative actions."

According to the Army, 89% of the National Guard has received one dose of the COVID vaccine, and 87% are fully immunized. The Army Reserve charts 89% of its personnel as having received one vaccine dose as well, and 88% are fully vaccinated.

In the Army's active-duty component branch, 97% of personnel are fully vaccinated. The Army began separating soldiers who had not received the jab back in February, and has separated 1,148 to date.
 

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COVID cases up by more than 30% in Britain last week
Fri, July 1, 2022, 8:09 AM

LONDON (AP) — The number of new coronavirus cases across Britain has surged by more than 30% in the last week, new data showed Friday, with cases largely driven by the super infectious omicron variants.
Data released by Britain's Office for National Statistics showed that more than 3 million people in the U.K. had COVID-19 last week, although there has not been an equivalent spike in hospitalizations. The number of COVID-19 deaths also fell slightly in the last week.

“COVID-19 has not gone away,” said Dr. Mary Ramsay, of the Health Security Agency. “It is also sensible to wear a face covering in crowded, enclosed spaces,” she said. Britain dropped nearly all its coronavirus measures, including mask-wearing and social distancing months ago and masks are rarely seen on public transport.

The latest jump in coronavirus cases comes after an earlier increase of about 40% last month, following the large street parties, concerts and festivities held to mark the platinum jubilee celebrations marking 70 years of Queen Elizabeth II's reign.

British officials said the latest wave of COVID-19 infections were likely caused by omicron subvariants BA.4. and BA.5. Omicron has tended to cause a milder disease than previous variants like alpha or delta, but scientists warn its ability to evade the immune system means that people may be more susceptible to being reinfected, including after vaccination.

“The constant bombardment of waves we are seeing does cause clinical impact that is not to be underestimated,” said Dr. Stephen Griffin, an associate professor of medicine at the University of Leeds, explaining that any infection can lead to long COVID.

Despite widespread immunization across Britain, the protection from vaccines is likely fading and omicron and its subvariants have evolved to become more infectious. Britain's Health Security Agency said they were seeing more outbreaks in care homes for older people and a rise in admissions to intensive care units of people over 65.

Dr. Jonathan Van-Tam, a former deputy chief medical officer for the U.K., told the BBC that COVID-19 is now “much, much, much closer to seasonal flu” than when it first emerged. Still, he said experts should be vigilant for any signs the virus was causing more severe illness.

Germany's Robert Koch Institute also reported a similar rise in the coronavirus, with cases increasing especially among older people, children and teenagers. France has seen a jump in the COVID-19 hospitalization rate and officials recently recommended that people begin wearing masks again on public transport.

Globally, the World Health Organization said this week that COVID-19 is increasing in more than 100 countries worldwide.
The U.N. health agency warned that relaxed testing and surveillance measures mean it may be more difficult to catch emerging variants before they spread more widely.
 

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The Insufferable Arrogance of the Constantly Wrong
By Clayton Fox
June 30, 2022

The media, and the people who work in and around it, the Blue Checks™ of Twitter, have upped the ante over the past few years regarding how far they are willing to go to enforce various preferred narratives.

Pick any major story of the past three years—e.g. Lab Leak, Jussie Smollett, Russiagate, Ukrainian Biolabs, Ivermectin, Hospitalizations From COVID v. With Covid, January 6th, ‘Transitory’ Inflation, and of course Hunter’s Laptop—and you will find absolutely hysterical narrative pushing up front followed by retractions, corrections, and outright denials as reality became undeniable.

In the meanwhile, our civilization was ripped apart, our citizens were gaslit and impoverished, and in countries across the Western world, innocent people were removed from polite society, branded as lepers, and fired from their jobs.

Why? Because there is one story that just won’t die and for which no corrections have been issued—the shibboleth that vaccination can prevent infection, transmission, and help “end” COVID.

While there is never an excuse for hateful rhetoric towards, and intervention in, the personal medical choices of law-abiding Americans, perhaps one could have, kinda sorta, understood the campaign if the new vaccines had provided long-lasting immunity and prevented community transmission. They do not.

Early on we were told: “Nine out of ten [vaccinated] people won’t get sick” (Columbia University feat. Run-DMC, February 12th, 2021, no this is not a joke); “Vaccinated people do not carry the virus, don`t get sick” (Dr. Rochelle Walensky, March 29th, 2021); “When people are vaccinated, they can feel safe that they are not going to get infected” (Dr. Anthony Fauci, May 17th, 2021).

And by mid-summer, 2021, we were still being told that unequivocally, these vaccines were a resounding success worthy of uncritical support. On July 27th in Scientific American, Dr. Eric Topol wrote, “Vaccination is the closest thing to a sure thing we have in this pandemic.” Not to be outdone, Dr. Anthony Fauci of the NIAID told CBS on August 1st, that the unvaccinated were responsible for “propagating this outbreak.”

But on July 29th, 2021, the Washington Post reported a scoop that the CDC was privately acknowledging that the vaccinated could spread COVID as easily as the unvaccinated. Occasionally, they are forced to report inconvenient facts. And August 5th, CDC Director Walensky told CNN’s Wolf Blitzer that, “They continue to work well for Delta, with regard to severe illness and death — they prevent it. But what they can’t do anymore is prevent transmission.”

While there is a mountain of medical literature available demonstrating quite clearly the failure of these vaccines to prevent infection and transmission, the August 5th declaration from the CDC Director should have made clear that being vaccinated is contributing in no way to the safety of others, nor to the eradication of this virus.

In fact, Israeli Health Minister Nitzan Horowitz was even caught on tape in September of last year explaining that the use of the Israeli Green Pass wasn’t intended to make a difference epidemiologically, but because it would help convince people to get vaccinated. And even vaccine poobah Bill Gates admitted in a late 2021 interview, that, “We got vaccines to help you with your health, but they only slightly reduce the transmissions.”

So there should be no question that continuing to suggest in any way that these shots are a panacea, and that those who refused to get them were plague spreaders, should have been thoroughly trashed by Fall 2021.

Nonetheless, on September 24th President Joe Biden coined his now famous phrase “a pandemic of the unvaccinated.” To our north, Prime Minister Trudeau called the unvaccinated science deniers, misogynists, and racists, and asked rhetorically whether Canadians should “tolerate” them.

And during the first week of January 2022, while kicking the unvaccinated out of French daily life and public spaces, French President Emmanuel Macron said he wanted the measures to “piss off” his unvaccinated citizens. With world leaders speaking this way, it’s no wonder so many Blue Check™ elites took up the banner!

Prominent media figures like Amy Siskind, Pulitzer Prize winner Gene Weingarten, and more have come out of the woodwork in recent months to share with us their enthusiasm for medical discrimination. Noted neurotic Howard Stern is all in on forced vaccination due to what must be his own debilitating fear of his mortality. Bill Kristol says the unvaccinated have “blood on their hands.”

David Frum, heir to Maimonides, writes, “Let the hospitals quietly triage emergency care to serve the unvaccinated last.” Charles M. Blow was “furious” at the unvaccinated. CNN contributor Dr. Leana Wen suggested that the unvaccinated should not be allowed to leave their homes. The Ragin’ Cajun even wants to punch the unvaccinated in the face!

All of the above links/stories were posted after Dr. Walensky’s unequivocal announcement that the vaccines do not prevent transmission.

And all of the self-satisfied segregationists are supported in their vitriol by the Blue Checks™ of the Medical Establishment, like Dr. Paul Klotman, President and Executive Dean of the Baylor School of Medicine, who said on camera back in January that he isn’t polite to friends and family who aren’t vaccinated. “Keep them away. I don’t do it respectfully, I tell them to stay away, and teach them a lesson.” Less vitriolic but equally problematic, the WHO’s COVID-19 “technical lead” Dr. Maria Van Kerkhove continued to push the lie that vaccination can prevent outbreaks as recently as January 26th, 2022. She is, as well, a Blue Check™. And yes, Dr. Anthony Fauci is still at it, even as of April 14th, 2022, telling MSNBC that harsh Chinese lockdowns could be used to get the population vaccinated so that “When you open up, you won’t have a surge of infections.”

The examples are legion. Blue Checks, Medical Blue Checks, Times Columnists, Radio Jocks, Presidents, and Prime Ministers have all espoused misinformation and/or hate speech regarding vaccination status. But they are all given intellectual cover by the official reporting of the fourth estate. Even in the face of all the evidence that there is no epidemiological basis for discrimination, our intellectual betters in the legacy media press onward the canard.

On August 26th, the Toronto Star ran an article entitled, “When it comes to empathy for the unvaccinated, many of us aren’t feeling it.” Then, on December 22nd, published an explainer which stated that two doses won’t stop you from spreading COVID-19. Comme ci, comme ca.

Back in February, MSNBC political contributor Matthew Dowd shared his insight that the unvaccinated do not believe in the United States Constitution, because if they did, they would get vaccinated for “We The People.” For the common good.

An examination of the New York Times reveals three articles written this year which overtly continue supporting the idea that the vaccines prevent transmission. First, on January 29th in a piece entitled, “As Covid Shots For Kids Stall, Appeals Are Aimed At Wary Parents,” the author cites “public health officials” who say that to aid in “containing” the pandemic, kids must also be vaccinated. (It is worth mentioning that the current vaccines and boosters being distributed were designed in February 2020 to provide an immune response to a version of the SARS-CoV-2 spike protein circulating prior to that, not entirely similar to what is circulating now.)

Then February 23rd, in a hit piece on the Surgeon General of Florida Dr. Joe Ladapo, the Times writes, “When public health officials across the country were urging vaccines as a way to end the pandemic, Dr. Ladapo was raising warning flags about possible side effects and cautioning that even vaccinated people could spread the virus.”

So, Dr. Ladapo was correct?

Finally, in a piece about Novak Djokovic published March 3rd, they write, “Djokovic was the only player ranked in the top 100 in Australia who had not received a Covid-19 vaccination, which experts have long said will not eradicate the virus unless most of the population receives one.”

They do not address the question of how a vaccine which does not prevent transmission can eradicate a virus. And they won’t. As Israeli Health Minister Horowitz candidly admitted, none of this is about epidemiology.

And even when mainstream media tacitly acknowledges the failures of the vaccines to prevent transmission, they skillfully elide the significance of this fact in order to allow them to continue to scapegoat the unvaccinated. In a dazzling display of sophistry, Time Magazine moved the Overton window in this January 12th, 2022 piece, “These Charts Show That COVID-19 Is Still A Pandemic of the Unvaccinated.”

The author states that due to the rapidly narrowing gap between cases in the vaccinated and unvaccinated, some readers might think that the phrase “pandemic of the unvaccinated” is no longer justifiable. But with the grace of a ballerina, Time goes on to tell us that because the vaccines are still showing efficacy against severe illness, the phrase is still kosher. If an unvaccinated person gets sicker than his vaccinated neighbor who contracted COVID at a fully vaccinated wedding, that unvaccinated person is still the problem!

New York Magazine isn’t lacking in similar gymnastics. On February 16th of this year, Matt Stieb published a piece entitled, “Is Kyrie Irving Going to Get Away With It?” Irving is the Brooklyn Nets player who famously chose not to be vaccinated, and has become a fetish object for the Covidian Left. Stieb acknowledges that Irving’s vaccinated teammates were getting COVID at such high rates that it forced Nets management to allow Irving back to play in away games but still calls the New York City ban on unvaccinated athletes “a rare public health mandate with real teeth.”

Just seven days later on February 23rd, Will Leitch, in the same publication, sighs, “Unfortunately, It’s Time to Let Kyrie Irving Play in New York.” He outlines all the reasons why epidemiologically it makes no sense to prevent athletes like Irving and Novak Djokovic from participating, but says, “It would feel like they got away with all their bullshit.” And also, they are “annoying.”

And this barely concealed hatred for the unvaccinated from media and government and Big Tech—even in the rare moments when writers such as Leitch acknowledge the failure of the vaccines to prevent transmission—has real consequences. People have lost their jobs. People have been arrested for trying to go to a movie theater.

Families got kicked out of restaurants, and patrons either cheered or remained indifferent, which is worse. A teenage boy at an uber-progressive and expensive Chicago prep school committed suicide after being bullied over an incorrect rumor he was unvaccinated. The stench of bad journalism rots people’s basic decency.

A January Rasmussen poll found that, “Fifty-nine percent (59%) of Democratic voters would favor a government policy requiring that citizens remain confined to their homes at all times, except for emergencies, if they refuse to get a COVID-19 vaccine…Forty-five percent (45%) of Democrats would favor governments requiring citizens to temporarily live in designated facilities or locations if they refuse to get a COVID-19 vaccine…”

As well as, “Twenty-nine percent (29%) of Democratic voters would support temporarily removing parents’ custody of their children if parents refuse to take the COVID-19 vaccine.” Unfortunately, these disturbing results are politically lopsided, but it’s no surprise when you consider who the readers of most legacy media platforms are.

The saddest thing is that these media outlets and their flag bearers really think their readers are all morons. The New York Times believes that, in the midst of the Omicron wave as boosted person after boosted person was getting COVID, they could tell you these particular vaccines are still the way to eradicate this thing, and expect you to deny reality and nod your head.

It calls to mind the quote attributed to Solzhenitsyn (or Elena Gorokhova), “The rules are simple: they lie to us, we know they’re lying, they know we know they’re lying, but they keep lying to us, and we keep pretending to believe them.”

We have ceded the better angels of our common cerebrum to people who may not have our best interests at heart, and a sycophantic laptop class who gleefully endorses their diktats and “fact-checks.” Collectively: Sophistry Inc.

Their behavior, endorsed by every single entity which holds power in our society, is destroying us, and has already poisoned us such that there may be no antidote. Yes, first they came for the unvaccinated, but that doesn’t mean they won’t come for you next.
 

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Pfizer Asks for Formal Approval of Drug Paxlovid Amid ‘COVID Rebound’ Reports
By Jack Phillips
July 1, 2022

Pharmaceutical giant Pfizer asked federal officials to formally approve its Paxlovid treatment for COVID-19 although the Centers for Disease Control and Prevention (CDC) last month issued an alert to health care providers that the drug can cause “COVID rebound” symptoms.

Pfizer confirmed on Thursday that it submitted a new drug application Paxlovid to the U.S. Food and Drug Administration (FDA) for the treatment of COVID-19 in vaccinated and unvaccinated individuals who are at a high risk of developing severe symptoms. The medication is currently being administered via an emergency use authorization across the United States.

“As the COVID-19 pandemic continues to evolve and be highly unpredictable, we must remain vigilant in protecting those who are at greatest risk of getting very sick from COVID-19, as they remain vulnerable to potential hospitalization or even death,” claimed Pfizer CEO Albert Bourla in a statement, adding that the company believes Paxlovid is an “option for mild-to-moderate COVID-19.”

Pfizer’s stock on Thursday rose about 3 percent after submitting the application to the FDA, although it dropped 1.6 percent during Friday morning’s session.

More than 1.6 million courses of Paxlovid have been administered in the United States, according to data from the Department of Health and Human Services. The medication is authorized in about 65 other countries, the company said Thursday.

‘COVID Rebound’

The development comes as White House medical adviser Anthony Fauci, who has received four COVID-19 vaccine doses, revealed on Tuesday that he is taking Paxlovid and dealing with a rebound of symptoms from the Pfizer drug.

“After I finished the five days of Paxlovid, I reverted to negative on an antigen test for three days in a row,” Fauci stated during a virtual meeting. “And then on the fourth day, just to be absolutely certain, I tested myself again. I reverted back to positive.”

Fauci then said that “over the next day or so, I started to feel really poorly, much worse than in the first go around,” adding, “So, I went back on Paxlovid and right now I am on my fourth day of a five-day course.”

The CDC last month issued an alert to health care providers, public health departments, and other officials about the possible recurrence of symptoms, which it described as “COVID-19 rebound.”

“Paxlovid continues to be recommended for early-stage treatment of mild to moderate COVID-19 among persons at high risk for progression to severe disease,” said the agency in the notice, but it stipulated that “COVID-19 rebound has been reported to occur between 2 and 8 days after initial recovery and is characterized by a recurrence of COVID-19 symptoms.”
 

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COVID Vaccines Increase Menstrual Irregularities Thousandfold, Fetal Abnormalities Hundredfold: Doctors’ VAERS Analysis
By Enrico Trigoso
July 1, 2022

New disturbing pharmacovigilance signals from VAERS surrounding the use of the COVID vaccines on women of reproductive age prompted a group of doctors to call for a ban on the gene therapy COVID-19 vaccines.
Over the past two weeks, Dr. James Thorp, a maternal-fetal medicine expert, painstakingly analyzed and verified the most recent Vaccine Adverse Event Reporting System (VAERS) data related to COVID-19 vaccines and compared them to the influenza vaccines.

“COVID-19 vaccines compared to the influenza vaccines are associated with increases in menstrual disorders, miscarriage, fetal chromosomal abnormalities, fetal cystic hygroma, fetal malformations, fetal cardiac arrest, fetal cardiac arrhythmias, fetal cardiac disorders, fetal vascular mal-perfusion abnormalities, abnormal fetal surveillance testing, abnormal fetal growth patterns, placental thrombosis, and fetal death,” Thorp told The Epoch Times last week.

His findings are listed below:
  • Abnormal uterine bleeding (menstrual irregularity) is 1000-fold greater
  • Miscarriages are 50-fold greater
  • Fetal chromosomal abnormalities are 100-fold greater
  • Fetal malformation is 50-fold greater
  • Fetal cystic hygroma (a major malformation) is 90-fold greater
  • Fetal cardiac disorders are 40-fold greater
  • Fetal arrhythmia is 50-fold greater
  • Fetal cardiac arrest is 200-fold greater
  • Fetal vascular mal-perfusion is a 100-fold greater
  • Fetal growth abnormalities are 40-fold greater
  • Fetal abnormal surveillance tests are 20-fold greater
  • Fetal placental thrombosis is 70-fold greater
Thorp said that he verified his analysis with a DOD (Department of Defense) statistical consultant that agreed to help him on the condition of anonymity.

Lack of Safety Testing

Regarding the VAERS data, vaccinologist Dr. Robert Malone, a key contributor of mRNA technology, told The Epoch Times on Thursday: “The risky strategy of authorizing the emergency use of mRNA ‘vaccine’ products prior to completion of rigorous non-clinical animal testing for reproductive and genotoxicity risks, followed by advocacy of widespread use in pregnancy, now appears to have resulted in substantial and avoidable reproductive toxicity.”

“Prior non-clinical (animal model) data from the Pfizer Emergency Use Authorization data package, together with the absence of adequate data and testing of safety during pregnancy have resulted in avoidable reproductive and fetal toxicities,” Malone further noted.

He stressed that expectant mothers should avoid the “experimental” COVID vaccines and that their infants should not be injected with them.

“These new VAERS data and analyses demonstrate that both reproductive-aged mothers and their infants have been damaged by accepting unlicensed, inadequately tested, emergency use authorized genetic vaccines,” Malone said.
Earlier this year Jessica Rose Ph.D. co-authored a VAERS analysis that got withdrawn by the academic journal Elsevier.
She told The Epoch Times that Thorp’s analysis aligns perfectly with hers.

“I do believe it is not only important, but necessary, to pull these products from pregnant/breastfeeding women and infants since there is no long-term safety data and the short-term data looks bad. As per both Moderna and Pfizer’s safety documents presented to VRBPAC pre-EUA granting for 0- 4-year-olds, this applies. They both showed terrible risk,” Rose said.

Christiane Northrup, MD., a fellow of the American College of Obstetrics and Gynecology, also stands by the analysis.
“Having been on the front lines of the DES disaster as a young OB/GYN, I am astounded that we are repeating the same kind of mistake but on a far more devastating level. COVID-19 shots must be stopped immediately in all pregnant women before further damage is done to the next generation,” Northrup told The Epoch Times.

Thorp continued: “All of these adverse outcomes are statistically significant (p value < 0.0001)–in other words, the probability of these adverse outcomes occurring by chance alone is less than 1 in 10,000. It was incumbent upon the COVID-19 vaccine manufacturers, FDA, CDC, American College of Obstetrics and Gynecology, Society for Maternal-Fetal Medicine, and American Board of Obstetrics and Gynecology to have demanded this safety data prior to pushing these dangerous ‘vaccines’ in pregnancy.”

“These institutions have violated the golden rule of pregnancy: new substances be it nutraceuticals, drugs, or vaccines have NEVER been allowed in pregnancy until long-term outcome data are available. Now, the COVID-19 vaccines make prior obstetrical disasters of diethyl stilbesterol (DES) and thalidomide look like prenatal vitamins. I am calling for a worldwide ban and moratorium on the use of any experimental gene therapy and/or COVID-19 ‘vaccines’ in pregnancy until long-term safety data are irrefutable,” Thorp stated.

According to medalerts.org, “The U.S. Government collects reports of adverse health events that follow the administration of a vaccine” and can be seen in the VAERS database publicly.

According to OpenVAERS, “VAERS is the Vaccine Adverse Event Reporting System put in place in 1990. It is a voluntary reporting system that has been estimated to account for only 1% of vaccine injuries.”

The VAERS official disclaimer, however, states: “While very important in monitoring vaccine safety, VAERS reports alone cannot be used to determine if a vaccine caused or contributed to an adverse event or illness.”
 

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Neurodevelopmental Changes Found in Babies Exposed to COVID in the Womb
By European Psychiatric Association
July 1, 2022

Differences in neurodevelopmental outcomes at 6 weeks are exhibited by babies born to mothers who had COVID-19 during pregnancy.

According to a preliminary analysis presented at the 30th European Congress of Psychiatry, babies delivered to moms who had COVID-19 during pregnancy appear to exhibit different neurodevelopmental outcomes at 6 weeks.

“Not all babies born to mothers infected with COVID show neurodevelopmental differences, but our data shows that their risk is increased in comparison to those not exposed to COVID in the womb. We need a bigger study to confirm the exact extent of the difference, ” said Project Leader Dr. Rosa Ayesa Arriola.

When compared to babies from non-infected mothers, researchers found that infants born to mothers who had been infected show greater difficulties in relaxing and adapting their bodies when they are being held. This is especially true when SARS-CoV-2 infection took place in late pregnancy. Moreover, infants born from mothers that had COVID-19 tend to show greater difficulty in controlling head and shoulder movement. These alterations suggest a possible COVID effect on motor function (movement control).

The study results come from an initial evaluation of the Spanish COGESTCOV-19 project, which followed the course of pregnancy and baby development in mothers infected with COVID-19. The researchers are presenting the data on pregnancy and post-natal assessment at 6 weeks after birth, but the project will continue to see if there are longer-term effects. The group will monitor infant language and motor development between 18 and 42 months old.

The initial evaluation compared babies born to 21 COVID-positive pregnant women and their babies, with 21 healthy controls attending the Marqués de Valdecilla University Hospital in Santander, Spain. The mothers underwent a series of tests during and after pregnancy. These included hormonal and other biochemical tests (measuring such things as cortisol levels, immunological response, etc.) salivary tests, movement responses, and psychological questionnaires. All analyses were adjusted for infant age, sex, and other factors.

The post-natal tests included the Neonatal Behavioral Assessment Scale (NBAS), which measures the baby’s movement and behavior.

Researcher Ms. Águeda Castro Quintas (University of Barcelona, Network Center for Biomedical Research in Mental Health), said:

“We found that certain elements of the NBAS measurement were changed in 6-week-old infants who had been exposed to the SARS-COV-2 virus. Effectively they react slightly differently to being held, or cuddled.”

We have been especially sensitive in how we have conducted these tests. Each mother and baby were closely examined by clinicians with expert training in the field and in the tests.

We need to note that these are preliminary results, but this is part of a project following a larger sample of 100 mothers and their babies. They have also been monitored during pregnancy and after birth. We also plan to compare these mothers and babies with data from another similar project (the epi-project) which looks at the effect of stress and genetics on a child’s neurodevelopment.”

Águeda Castro Quintas continued:

“This is an ongoing project, and we are at an early stage. We found that babies whose mothers had been exposed to COVID did show neurological effects at 6 weeks, but we don’t know if these effects will result in any longer-term issues, longer term observation may help us understand this.”

Co-researcher Nerea San Martín González, added:

“Of course, in babies who are so young, there are several things we just can’t measure, such as language skills or cognition. We also need to be aware that this is a comparatively small sample, so we are repeating the work, and we will follow this up over a longer period. We need a bigger sample to determine the role of infection on offspring’s neurodevelopmental alterations and the contribution of other environmental factors In the meantime, we need to stress the importance of medical monitoring to facilitate a healthy pregnancy, discussing any concerns with your doctor wherever necessary.”

Commenting, Project Leader Dr. Rosa Ayesa Arriola said:

“This is the right moment to establish international collaborations that would permit us to assess long-term neurodevelopment in children born during the COVID-19 pandemic. Research in this field is vital in understanding and preventing possible neurological problems and mental health vulnerabilities in those children in the coming years.”
In an independent comment, Dr. Livio Provenzi (University of Pavia, Italy) said:

“There is a great need to study both direct and indirect effects of the COVID-19 pandemic on the health and well-being of parents and infants. Pregnancy is a period of life which shapes much of our subsequent development, and exposure to adversity in pregnancy can leave long-lasting biological footprints. These findings from Dr. Rosa Ayesa Arriola’s group reinforce evidence of epigenetic alterations in infants born from mothers exposed to pandemic-related stress during pregnancy. It shows we need more large-scale, international research to allow us to understand the developmental effects of this health emergency, and to deliver better quality of care to parents and infants.”

Dr. Provenzi was not involved in this work.

Note: The epi-project is a multicentre project involving Hospital Clínic of Barcelona and Hospital Universitario Central de Asturias. It looks at the effects of genetics and stress on baby outcome. It is led by Prof. Dr. Lourdes Fañanás.

Funding: This research has been funded by the Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III through the University of Barcelona multicenter project – Intramural Grants (SAM15-20PI12 & SAM18PI01)-PI L. Fañanas and the Government of Cantabria (INNVAL20/02)-PI R. Ayesa. The authors do not have any conflict of interest regarding the development of this study and the publication of the results.
 

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A Better Kind of Face Mask: Researchers Develop Virus Killing Masks
By Rensselaer Polytechnic Institute
July 1, 2022

The research team utilized accessible and affordable equipment to improve N95 masks and cut waste

Researchers at Rensselaer Polytechnic Institute have created a practical method for producing N95 face masks that are both excellent germ barriers and on-contact germ killers. The antiviral and antibacterial masks may be worn for longer periods of time, which would result in less plastic waste as the masks would not need to be replaced as often.

In order to combat infectious respiratory diseases and environmental pollution, Helen Zha, assistant professor of chemical and biological engineering and a member of the Center for Biotechnology and Interdisciplinary Studies at Rensselaer (CBIS), worked with Edmund Palermo, associate professor of materials science and engineering and a member of the Center for Materials, Devices, and Integrated Systems (cMDIS) at Rensselaer.

“This was a multifaceted materials engineering challenge with a great, diverse team of collaborators,” Palermo said. “We think the work is the first step toward longer-lasting, self-sterilizing personal protective equipment, such as the N95 respirator. It may help reduce transmission of airborne pathogens in general.”

The researchers successfully grafted broad-spectrum antimicrobial polymers onto the polypropylene filters used in N95 face masks, according to the study that was recently published in Applied ACS Materials and Interfaces.

“The active filtration layers in N95 masks are very sensitive to chemical modification,” said Zha. “It can make them perform worse in terms of filtration, so they essentially no longer perform like N95s. They’re made out of polypropylene, which is difficult to chemically modify. Another challenge is that you don’t want to disrupt the very fine network of fibers in these masks, which might make them more difficult to breathe through.”

Zha and Palermo, along with other researchers from Rensselaer, Michigan Technological Institute, and Massachusetts Institute of Technology, covalently attached antimicrobial quaternary ammonium polymers to the fiber surfaces of nonwoven polypropylene fabrics using ultraviolet (UV)-initiated grafting. The fabrics were donated by Hills Inc. courtesy of Rensselaer alumnus Tim Robson.

“The process that we developed uses a really simple chemistry to create this non-leaching polymer coating that can kill viruses and bacteria by essentially breaking open their outer layer,” said Zha. “It’s very straightforward and a potentially scalable method.”

The team used only UV light and acetone in their process, which are widely available, to make it easy to implement. On top of that, the process can be applied to already manufactured polypropylene filters, rather than necessitating the development of new ones.

The team did see a decrease in filtration efficiency when the process was applied directly to the filtration layer of N95 masks, but the solution is straightforward. The user could wear an unaltered N95 mask along with another polypropylene layer with the antimicrobial polymer on top. In the future, manufacturers could make a mask with the antimicrobial polymer incorporated into the top layer.

Thanks to a National Science Foundation Rapid Response Research (RAPID) grant, Zha and Palermo started their research in 2020 when N95 face masks were in short supply.
Healthcare workers were even reusing masks that were
intended to be single-use. Fast forward to 2022 and face masks of all types are now widely available. However, COVID rates are still high, the threat of another pandemic in the future is a distinct possibility, and single-use, disposable masks are piling up in landfills.

“Hopefully, we are on the other side of the COVID pandemic,” said Zha. “But this kind of technology will be increasingly important. The threat of diseases caused by airborne microbes is not going away. It’s about time that we improved the performance and sustainability of the materials that we use to protect ourselves.”

“Attaching chemical groups that kill viruses or bacteria on contact with polypropylene is a smart strategy,” said Shekhar Garde, Dean of the School of Engineering at Rensselaer. “Given the abundance of polypropylene in daily life, perhaps this strategy is useful in many other contexts, as well.”

The study was funded by the NIH/National Institutes of Health.

Reference: “Virucidal N95 Respirator Face Masks via Ultrathin Surface-Grafted Quaternary Ammonium Polymer Coatings” by Mirco Sorci, Tanner D. Fink, Vaishali Sharma, Sneha Singh, Ruiwen Chen, Brigitte L. Arduini, Katharine Dovidenko, Caryn L. Heldt, Edmund F. Palermo and R. Helen Zha, 25 May 2022, ACS Applied Materials and Interfaces.

DOI: 10.1021/acsami.2c04165
 

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New COVID Antibody Detection Method Does Not Require a Blood Sample
By Institute of Industrial Science, The University of Tokyo
July 1, 2022

The global COVID-19 pandemic is not over, despite significant and stunning advances in vaccine technology. A key challenge in limiting the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been quickly and accurately identifying infected individuals. Now, investigators from Japan have developed a new antibody-based technique for the rapid and reliable detection of SARS-CoV-2 that does not require a blood sample.

The global response to the COVID-19 pandemic has been severely limited by the ineffective identification of SARS-CoV-2-infected individuals, and the high rate of asymptomatic infections (16%–38%) has exacerbated this situation. Thus far, the predominant detection method collects samples by swabbing the nose and throat. However, the application of this method has been limited by its long detection time (4–6 hours), high cost, and requirement for specialized equipment and medical personnel, particularly in resource-limited countries.

An alternative and complementary method for confirming COVID-19 infection involves the detection of SARS-CoV-2-specific antibodies. Testing strips based on gold nanoparticles are currently in widespread use for point-of-care testing in many countries. They produce sensitive and reliable results within just 10–20 minutes, but they require blood samples collected via a finger prick using a lancing device. This can be painful and increases the risk of infection or cross-contamination. Plus, the used kit components present a potential biohazard risk.

Lead author Leilei Bao from the Institute of Industrial Science, The University of Tokyo, explains: “To develop a minimally invasive detection assay that would avoid these drawbacks, we explored the idea of sampling and testing the interstitial fluid (ISF), which is located in the epidermis and dermis layers of human skin. Although the antibody levels in the ISF are approximately15%–25% of those in blood, it was still feasible that anti-SARS-CoV-2 IgM/IgG antibodies could be detected and that ISF could act as a direct substitute for blood sampling.”

After demonstrating that ISF could be suitable for antibody detection, the researchers developed an innovative approach to both sample and test the ISF. “First, we developed biodegradable porous microneedles made of polylactic acid that draws up the ISF from human skin,” explains Beomjoon Kim, senior author. “Then, we constructed a paper-based immunoassay biosensor for the detection of SARS-CoV-2-specific antibodies.” By integrating these two elements, the researchers created a compact patch capable of on-site detection of the antibodies within 3 minutes (result from in vitro tests).

This novel detection device has great potential for the rapid screening of COVID-19 and many other infectious diseases that is safe and acceptable to patients. It holds promise for use in many countries regardless of their wealth, which is a key aim for the global management of infectious diseases.

Reference: “Anti SARS CoV 2 IgM/IgG antibodies detection using a patch sensor containing porous microneedles and a paper based immunoassay” 1 July 2022, Scientific Reports.

DOI: 10.1038/s41598-022-14725-6
 

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NYC first to offer Paxlovid at COVID testing sites
July 1, 2022

New York City's Mayor Eric Adams announced Thursday that the city has launched the first-of-their-kind mobile COVID-19 testing units that will also dispense the antiviral drug Paxlovid to those who test positive for the virus.

The "Test-to-Treat" program is part of federal and city efforts to catch and treat infections early and be ready for new waves of the pandemic. Health officials also want to expand access to Paxlovid, especially for people who don't have a regular doctor or insurance, the New York Times reported.

"New York City may have been at the epicenter of the pandemic at the start, but now we are leading the way in prevention and mitigation," Adams said in his announcement. "By getting lifesaving medications into the hands of New Yorkers minutes after they test positive, we are once again leading the nation to quickly deliver accessible care to those who need it."

Adams, who took office in January, tested positive for the virus in April and has said that his infection was mild in part because he took Paxlovid.

White House COVID-19 Response Coordinator Dr. Ashish Jha told the Times there had been a major increase in the use of Paxlovid across the country over the last three months, and that 240,000 new prescriptions were reported last week, the highest weekly total so far. But he noted that those who test positive in poor communities had not gotten antiviral treatments as often as people in wealthy communities had.

"I love this idea," Jha said of the New York City program. "You can go to people where they are. I expect this to go very well, and it will be a great model for the rest of the country to follow."

Paxlovid, made by Pfizer Inc., can significantly reduce the severity of COVID-19 infection when taken early in the infection. The drug was approved for emergency use late last year by the U.S. Food and Drug Administration.

The "Test-to-Treat" program was first announced by President Joe Biden in March.

On Thursday, three mobile units were outside local drug stores in working-class neighborhoods, the Times reported. The number of sites will grow to more than 30 by the end of July.

Dr. Ted Long, executive director of the city's Test & Trace Corps, noted the first patient at a new mobile testing site outside a drug store in the Inwood section of Manhattan. The woman, who didn't have a cellphone, tested positive and left the pharmacy with Paxlovid.

"This effort is focused on equity," Long told the Times.

Dr. Ashwin Vasan, New York City's health commissioner, told the Times that plenty of Paxlovid is available for New Yorkers who need it.

"Now we're kind of awash in Paxlovid," Vasan said.
 

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Simulation technologies for optimizing COVID-19 drug therapies
by National University of Singapore
July 1, 2022

1656751313260.jpeg
Visual giving an impression of how the modeling and simulation strategy could help optimize drug therapies and protect vulnerable patients from COVID-19. Credit: National University of Singapore

NUS pharmaceutical scientists have developed a modeling and simulation strategy to evaluate the pharmacotherapy of COVID-19 related drugs and help guide dose adjustments for those in the vulnerable population.

There is great public interest regarding the drugs that were granted Emergency Use Authorizations (EUAs) by the United States Food and Drug Administration (FDA) for the treatment of COVID-19. These drugs include both Paxlovid and baricitinib. Paxlovid received its EUA in December 2021 for the treatment of non-hospitalized patients with mild to moderate COVID-19 at risk of progression to severe infection. Baricitinib, a medication typically used for the treatment of rheumatoid arthritis, was also issued with an EUA in November 2020 for the treatment of COVID-19 in hospitalized patients requiring supplemental oxygen. Both drugs are also prescribed for COVID-19 patients in Singapore.

The lack of full FDA approval during the public health emergency would mean that dosing information for these two drugs may be lacking for the adults in older age groups. Also, clinical trials could not be performed in a timely manner for this vulnerable cohort during this period. Multiple chronic health conditions and polypharmacy often accompany older adults and it is expected to take many years to complete the complex risk evaluation involved. This sets barriers for clinicians to make suitable decisions on an optimal COVID-19 drug therapy for their older patients.

To address this clinical conundrum, Professor Eric Chan from the Department of Pharmacy, National University of Singapore, developed a modeling and simulation strategy to evaluate the pharmacotherapy of two COVID-19 drugs, Paxlovid and baricitinib, under various virtual clinical scenarios. The research team utilized an approach termed as physiologically-based pharmacokinetic (PBPK) modeling to simulate the pharmacokinetics of their target drugs among virtual populations. This methodology has been accepted by FDA in several drug labels for dose recommendations in recent years as an alternative to real-world studies.

For Paxlovid therapy, the research team identified potential risks of drug-drug interactions for a specific group of patients through the PBPK-based simulation. These are COVID-19 patients with cardiovascular diseases and already undergoing treatment using anticoagulants, either rivaroxaban or warfarin. From their simulation outcomes, the team found a significant increase in bleeding tendency when the older patients are on rivaroxaban. Those receiving warfarin treatment are found to suffer from an increased risk of potential thrombotic events.

Dr. Ziteng Wang, one of the team members said, "We suggest dose adjustment of rivaroxaban to mitigate the risk of internal bleeding and up to two-weeks surveillance for warfarin treatment after Paxlovid discontinuation to avoid warfarin-related thrombosis."

In a separate study, the team analyzed the current dosage strategies of baricitinib, which was evaluated to be broadly adequate for older adults, except for those with mild renal dysfunction, who might benefit from a dose reduction by half.

Prof Chan said: "Our results provide scientific evidence for the rational dose adjustments of COVID-19 drugs and co-medications in a vulnerable cohort, who are underrepresented in current clinical guidelines. These novel findings are pertinent in supporting further clinical studies and systematic analyses of real-world data to ensure efficacious and safe COVID-19 drug therapies."

Dr. Tat Ming Ng, principal pharmacist (specialist) at the Tan Tock Seng Hospital, Singapore, commented, "PBPK modeling is a mechanistic and quantitative approach in understanding how the human body absorbs, distributes, metabolizes and excretes drugs under different scenarios that are influenced by intrinsic (age, disease, ethnicity, gender, genetic, pregnancy) and extrinsic (drug, food, smoking) factors. In terms of the treatment for COVID-19, the findings will be useful to help guide clinical scenarios where these drug interactions cannot be avoided."

The associated studies were published in Clinical Pharmacology & Therapeutics. The team plans to extend their virtual simulation strategy in the evaluation of other COVID-19 drugs to clinically relevant yet untested clinical scenarios.
 

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Researchers create 'COVID computer' to speed up diagnosis
by University of Leicester
July 1, 2022

Researchers at the University of Leicester have created a new AI tool that can detect COVID-19.

The software analyzes chest CT scans and uses deep learning algorithms to accurately diagnose the disease. With an accuracy rate of 97.86%, it's currently the most successful COVID-19 diagnostic tool in the world.

Currently, the diagnosis of COVID-19 is based on nucleic acid testing, or PCR tests as they are commonly known. These tests can produce false negatives and results can also be affected by hysteresis—when the physical effects of an illness lag behind their cause. AI, therefore, offers an opportunity to rapidly screen and effectively monitor COVID-19 cases on a large scale, reducing the burden on doctors.

Professor Yudong Zhang, Professor of Knowledge Discovery and Machine Learning at the University of Leicester says that their "research focuses on the automatic diagnosis of COVID-19 based on random graph neural network. The results showed that our method can find the suspicious regions in the chest images automatically and make accurate predictions based on the representations. The accuracy of the system means that it can be used in the clinical diagnosis of COVID-19, which may help to control the spread of the virus. We hope that, in the future, this type of technology will allow for automated computer diagnosis without the need for manual intervention, in order to create a smarter, efficient healthcare service."

Researchers will now further develop this technology in the hope that the COVID computer may eventually replace the need for radiologists to diagnose COVID-19 in clinics. The software, which can even be deployed in portable devices such as smart phones, will also be adapted and expanded to detect and diagnose other diseases (such as breast cancer, Alzheimer's Disease, and cardiovascular diseases).

The research is published in the International Journal of Intelligent Systems.
 

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Researchers develop rapid COVID-19 test to identify variants in hours
by UT Southwestern Medical Center
July 2, 2022

Last year, pathologist Jeffrey SoRelle, M.D., and colleagues developed CoVarScan, a rapid COVID-19 test that detects the signatures of eight hotspots on the SARS-CoV-2 virus. Now, after testing CoVarScan on more than 4,000 patient samples collected at UT Southwestern, the team reports in Clinical Chemistry that their test is as accurate as other methods used to diagnose COVID-19 and can successfully differentiate between all current variants of SARS-CoV-2.

"Using this test, we can determine very quickly what variants are in the community and if a new variant is emerging," said Dr. SoRelle, Assistant Professor of Pathology and senior author of the study. "It also has implications for individual patients when we're dealing with variants that respond differently to treatments."

The testing results at UT Southwestern's Once Upon a Time Human Genomics Center have helped public health leaders track the spread of COVID-19 in North Texas and make policy decisions based on the prevalence of variants. Doctors have also used the results to choose monoclonal antibodies that are more effective against certain strains infecting critically ill COVID-19 patients.

While a number of other tests for COVID-19 exist, they generally detect either a fragment of SARS-CoV-2 genetic material or small molecules found on the surface of the virus, and don't provide information to identify the variant. In addition, many researchers worry that these tests aren't accurate in detecting some variants—or may miss future strains. To determine which variant of COVID-19 a patient has, scientists typically must use whole genome sequencing, which is time-consuming and expensive, relying on sophisticated equipment and analysis to spell out the entire RNA sequence contained in the viruses.

In early 2021, Dr. SoRelle and his colleagues at UT Southwestern wanted to track how well current tests were detecting emerging variants of SARS-CoV-2. But they realized that sequencing a lot of specimens would not be timely or cost-effective, so they designed their own test, working in the McDermott Center Next Generation Sequencing Core, part of the Eugene McDermott Center for Human Growth and Development directed by Helen Hobbs, M.D., Professor of Internal Medicine and Molecular Genetics.

CoVarScan hones in on eight regions of SARS-CoV-2 that commonly differ between viral variants. It detects small mutations—where the sequence of RNA building blocks varies—and measures the length of repetitive genetic regions that tend to grow and shrink as the virus evolves. The method relies on polymerase chain reaction (PCR)—a technique common in most pathology labs—to copy and measure the RNA at these eight sites of interest.

To test how well CoVarScan works, Dr. SoRelle's team ran the test on more than 4,000 COVID-19-positive nasal swab samples collected at UT Southwestern from April 2021 to February 2022—from patients both with and without symptoms. The tests were validated with the gold-standard whole genome sequencing, and the results were used by doctors to choose treatments in some critically ill COVID-19 patients.

Compared to whole genome sequencing, CoVarScan had 96% sensitivity and 99% specificity. It identified and differentiated Delta, Mu, Lambda, and Omicron variants of COVID-19, including the BA.2 version of Omicron, once known as "stealth Omicron" because it did not show up on some tests designed to detect only the Omicron strain.

"A common critique of this kind of test is that it requires constant adjustment for new variants, but CoVarScan has not needed any adjustment in more than a year; it is still performing very well," said Dr. SoRelle. "In the future, if we did need to adjust it, we could easily add as many as 20 or 30 additional hotspots to the test."

Dr. SoRelle plans to continue developing CoVarScan as a commercial test and has a pending patent application based on this work. As the inventor of the genotyping PCR test for variants, Dr. SoRelle is entitled to income from its use.
 

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Emerging omicron subvariants BA.2.12.1, BA.4 and BA.5 are inhibited less efficiently by antibodies
by Susanne Diederich, The German Primate Center
July 1, 2022

The omicron subvariants BA.1 and BA.2 of SARS-CoV-2 have dominated the COVID-19 pandemic in early 2022. In many countries, these viruses are now outcompeted by emerging subvariants, with BA.5 being responsible for the current uptick of cases in Germany. However, it is at present largely unclear whether the "new" omicron subvariants BA.2.12.1, BA.4, and BA.5 acquired biological traits that allow for more efficient transmission or whether they are less efficiently blocked by antibodies compared to the "old" omicron subvariants BA.1 and BA.2.

A study by researchers at the German Primate Center (DPZ)—Leibniz Institute for Primate Research together with colleagues from Hannover Medical School and Friedrich-Alexander-University Erlangen-Nürnberg shows that most of the therapeutic antibodies available for treatment of COVID-19 patients do not inhibit BA.2.12.1, BA.4, and BA.5 at all or only inhibit with reduced potency.

The antibody Bebtelovimab constitutes the only exception, since this antibody blocked all tested variants with high efficiency. Furthermore, the study shows that the omicron subvariants BA.2.12.1 and especially BA.4 and BA.5 are inhibited worse than their predecessors BA.1 and BA.2 by antibodies generated after vaccination or inoculation followed by infection. Thus, BA.2.12.1, BA.4, and BA.5 are immune escape variants. A pass-through infection with "old" omicron subvariants confers only limited protection against infection with "new" subvariants. The research was published in The Lancet Infectious Diseases.

New SARS-CoV-2 variants emerge because of errors during viral genome replication. Thus, the virus acquires mutations that change the viral proteins, including the surface protein, spike, the central target of the antibody response. In case the mutations reduce recognition of the spike protein by antibodies, such variants become more adept at spreading among people with preexisting immunity due to vaccination or past infection.

Infection researchers at the German Primate Center specialize in the analyses of SARS-CoV-2 inhibition by antibodies. With colleagues at Hannover Medical School and Friedrich-Alexander-University Erlangen-Nürnberg, they have investigated inhibition of the SARS-CoV-2 omicron subvariants BA.2.12.1, BA.4, and BA.5 by antibodies. BA.2.12.1, BA.4, and BA.5 (the spike protein of the latter two subvariants is identical) are becoming dominant in several countries and BA.5 is largely responsible for the recent uptick of cases in Germany.

The team, including Prerna Arora, Markus Hoffmann and Stefan Pöhlmann at the German Primate Center, found that out of ten therapeutic antibodies studied only two were able to at least partially inhibit BA.2.12.1, BA.4, and BA.5 and that only one antibody, Bebtelovimab (LY-CoV1404), efficiently blocked infection by all omicron subvariants.

"These results confirm a trend that we have already seen in previous studies: omicron subvariants are not appreciably inhibited by most therapeutic antibodies and the few antibodies that inhibit frequently do so in a subvariant-specific fashion. Therefore, it is important to develop new antibodies in order be prepared for future subvariants," says Prerna Arora, first author of the study.

Antibodies from unvaccinated individuals that were infected with omicron subvariants BA.1 or BA.2 in spring 2022 neutralized BA.2.12.1 with similar efficiency but were much less potent against BA.4 and BA.5. Therefore, it is likely that a previous BA.1 or BA.2 infection provides little protection against a subsequent infection with BA.4 or BA.5.

Antibodies induced by three immunizations with the mRNA vaccine of BioNTech/Pfizer blocked all omicron subvariants. However, inhibition was less efficient as compared to that measured for a virus that circulated early during the pandemic, and inhibition of BA.2.12.1, BA.4, and BA.5 was less efficient as compared to BA.1 and BA.2. Similar results were obtained for antibodies induced upon vaccination plus breakthrough infection. Although this so-called hybrid immunity conferred overall higher neutralizing activity against all variants tested, inhibition of BA.2.12.1, BA.4 and BA.5 was significantly reduced.

"BA.2.12.1 and particularly BA.4 and BA.5 are antibody evasion variants. Vaccination will still protect against severe disease induced by these variants but protection might be somewhat less efficient as that measured for previously circulating variants," says Markus Hoffmann, senior author of the study.

"Our future studies must show whether BA.2.12.1, BA.4 and BA.5 are not only less efficiently inhibited by antibodies but are also better at infecting lung cells. If this is the case, then an uptick in hospitalizations might be the consequence, although it should be stated that this has so far not been observed in South Africa, where BA.4 and BA.5 were first detected," comments Stefan Pöhlmann, who headed the study jointly with Markus Hoffmann.
 

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Researchers develop antibody test to keep track of immunity to SARS-CoV-2 variants
by University of Toronto
July 1, 2022

The experts agree—the pandemic is not over. Infections are ticking up again, fueled by the new variants our immune systems are ill prepared for.

That's according to a study by Canadian and US researchers who found that the antibodies generated in people who were vaccinated and/or recovered from COVID-19 prior to 2022 failed to neutralize the variants circulating today.

The study was led by Igor Stagljar, a professor of biochemistry and molecular genetics, at the Donnelly Centre for Cellular and Biomolecular Research, at Temerty Faculty of Medicine, and Shawn Owen, an associate professor of pharmaceutics and pharmaceutical chemistry, at the University of Utah.

The journal Nature Communications published their findings.

The researchers expect that the antibody test they developed to measure immunity in the study's participants will become a valuable tool for deciding who needs a booster and when, which will help save lives and avoid future lockdowns.

"The truth is we don't yet know how frequent our shots should be to prevent infection," said Stagljar. "To answer these questions, we need rapid, inexpensive and quantitative tests that specifically measure SARS-CoV-2 neutralizing antibodies, which are the ones that prevent infection."

Many antibody tests have been developed over the past two years. But only a few of the authorized ones are designed to monitor neutralizing antibodies, which coat the viral spike protein so that it can no longer bind its receptor and enter cells.

It's an important distinction, as only a fraction of all SARS-CoV-2 antibodies generated during infection are neutralizing. And while most vaccines were specifically designed to produce neutralizing antibodies, it's not clear how much protection they give against variants.

"Our method, which we named Neu-SATiN, is as accurate as, but faster and cheaper than, the gold standard, and it can be quickly adapted for new variants as they emerge," he said.

Neu-SATiN stands for Neutralization Serological Assay based on split Tri-part Nanoluciferase, and it is a newer version of SATiN, which monitors the complete IgG pool, which they developed last year.

The development of Neu-SATiN was spearheaded by Zhong Yao, a senior research associate in Stagljar's lab, and Sun Jin Kim, a postdoctoral fellow in Owen's lab, who are the co-first authors on the paper.

The first of its kind, the pin prick test is powered by a protein-complementation strategy using the fluorescent luciferase protein from a deep-water shrimp. It measures the ability of the viral spike protein to bind the human ACE2 receptor, each of which is attached to a luciferase fragment. The binding brings the luciferase pieces into proximity so that they reconstitute a full-length protein, which gives off a glow of light that is captured by the luminometer instrument. When patient blood sample is added into the mixture, the neutralizing antibodies will bind the spike protein, preventing it from contacting ACE2. Consequently, luciferase remains in pieces, with an accompanying drop in light signal. The plug and play method can be adapted to different variants within a couple of weeks by engineering variant mutations into the spike protein.

The researchers applied Neu-SATiN to blood samples collected from 63 patients with different histories of COVID-19 infection and vaccination up to November 2021. Patient neutralizing capacity was assessed against the original Wuhan strain and the variants, Alpha, Beta, Gamma, Delta and Omicron.

"We thought it would be important to monitor people that have been vaccinated to see if they still have protection and how long it lasts," said Owen, who did his postdoctoral training in the Donnelly Centre with distinguished bioengineer and University Professor Molly Shoichet. "But we also wanted to see if you were vaccinated against one variant, does it protect you against another variant?"

The neutralizing antibodies were found to last about three to four months when their levels would drop by about 70 percent irrespective of infection or vaccination status. Hybrid immunity, acquired through both infection and vaccination, produced higher antibody levels at first, but these too dropped significantly four months later.

Most worryingly, infection and/or vaccination provided good protection against the previous variants, but not Omicron, or its sub-variants, BA.4 and BA.5.

The data match those from a recent UK study, which showed that both neutralizing antibodies and cellular immunity, a type of immunity provided by memory T cells, from either infection, vaccination, or both, offered no protection from catching Omicron. In a surprising twist, the UK group also found that infections with Omicron boosted immunity against earlier strains, but not against Omicron itself, for reasons that remain unclear.

It's important to stress that vaccines still confer significant protection from severe disease and death, said Stagljar. Still, he added that the findings from his team and others call for vigilance in the coming period given that the more transmissible BA4 and BA5 sub-variants can escape immunity acquired from earlier infections with Omicron, as attested by rising reinfections.

"There will be new variants in the near future for sure," Stagljar said. "Monitoring and boosting immunity with respect to circulating variants will become increasingly important and our method could play a key role in this since it is fast, accurate, quantitative and cheap."

His lab is already collaborating with the Canadian vaccine maker Medicago to help determine the efficacy of their vaccine candidates against Omicron and its subvariants. Meanwhile, U of T is negotiating to license Neu-SATiN to a company which will scale it up so that it can be used for population immunosurveillance and in the pharmaceutical industry for vaccine development.
 

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Since the COVID Vaccine roll-out, all sorts of diseases have started to reappear. Why? Because the COVID Vaccines cause AIDS
By The Exposé on July 1, 2022

It feels like we can’t go a single week without hearing about the re-emergence, or emergence of a disease or ailment at the moment.

We’ve had a mysterious outbreak of hepatitis among children, an alleged monkeypox outbreak across every continent, a rise in “Sudden Adult Death Syndrome”, and now the UK Government has declared a ‘national incident’ after allegedly discovering the polio virus in England.

All of these discoveries follow an alleged Covid-19 pandemic, and all of them are “coincidentally” being found after millions of people around the world have been injected with an experimental mRNA Covid-19 vaccine.

This is precisely why we shouldn’t really be that surprised. Because all we’re witnessing is the consequences of the damage done to millions of immune systems around the world by these experimental vaccines, with official Government data suggesting that damage is so severe that the Covid-19 vaccinated are slowly developing Acquired Immune Deficiency Syndrome.

Let’s take a look at just a few of the recent diseases and viruses being publicised in the mainstream media.

On the 22nd June, the UK Heath Security Agency (UKHSA), working with the Medicines and Healthcare products Regulatory Agency (MHRA), announced it had found poliovirus in sewage samples collected from the London Beckton Sewage Treatment Works.

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Source

The last case of wild polio contracted in the UK was confirmed in 1984. The UK was declared polio-free in 2003. Wastewater surveillance is being expanded to assess the extent of transmission and identify local areas for targeted action.

Since around the middle of May 2022, you will have most likely heard or seen the word Monkeypox mentioned numerous times in the mainstream media.

Allegedly, for the first time since its discovery among humans in Africa over 50 years ago, the monkeypox virus is circulating throughout several countries including the USA, UK, Canada, Brazil, Australia and most of Europe all at the same time.

But it just so happens that every single country where monkeypox is allegedly circulating is also a country that has distributed the Pfizer Covid-19 injection to its population; excluding some countries in Africa where the disease has been endemic for the past 50 or so years.

Click on the below image and take a good long look to compare which countries have reported cases of monkeypox to the W.H.O. since May 2022, and which countries have distributed the Pfizer Covid-19 injection.



Every single country that has reported cases of monkeypox has also distributed the Pfizer jab. And there are only a handful of countries where the Pfizer jab has been administered that haven’t reported a case of monkeypox to the W.H.O.

Next up we have hepatitis.

On April 15 2022, the World Health Organization issued a global alert about a new form of severe acute Hepatitis with an unknown aetiology (cause) affecting previously healthy children. Tests have excluded all previously known Hepatitis viruses.

The announcement came after the UK Health Security Agency (UKHSA) recently detected higher than usual rates of liver inflammation (hepatitis) in children.

The hepatitis infections had been confirmed to have hit children in at least twelve different countries, with the majority of those cases spiking in the UK.

Do you remember that old saying?

‘You wait one hundred years for a pandemic and then three to four come along at once.’

Of course you don’t. And these health emergencies aren’t all occurring due to some unfortunate coincidence. They’re occurring because the Covid-19 injections cause recipients to develop Acquired Immune Deficiency Syndrome, and we can prove it.

For months on end, Governments have been publishing data that strongly suggest the Covid-19 injections damage the immune system so much that recipients are developing some new form of Acquired Immune Deficiency Syndrome (AIDS). The most reliable example of this has come from the UK Health Security Agency (UKHSA).

The following chart shows the Covid-19 vaccine effectiveness among the triple vaccinated population in England in the Week 3, Week 7 and Week 13 UKHSA Vaccine Surveillance reports of 2022 –

image-357.png


This is certainly nowhere near the claimed 95% effectiveness by Pfizer, is it?

The following chart shows the Covid-19 death rate per 100,000 individuals by vaccination status between 28th Feb and 27th March 22. The unvaccinated case rate has been taken from page 45 of the UKHSA Vaccine Surveillance Report – Week 13 – 2022, and the double vaccinated case rate has been calculated with the number of deaths provided on page 44 of the same report –

image-358.png


The above figures prove the Covid-19 injections are damaging the immune system because vaccine effectiveness isn’t actually a measure of a vaccine, it’s a measure of the immune system.

The Covid-19 vaccines instruct the body to produce the spike (S) protein of the original Covid-19 virus. The immune system is then supposed to rid the body of these manufactured spike proteins and remember to do so if it ever encounters the “real” virus in the future.

image-359.png


Therefore, the UKHSA figures prove the immune systems of the vaccinated are performing far worse than the immune systems of the unvaccinated.

A scientific study also found Covid-19 Vaccines suppress the Innate Immune System.

The study titled ‘Innate Immune Suppression by SARS-CoV-2 mRNA Vaccinations: The role of G-quadruplexes, exosomes and microRNAs‘ was published on the 21st Jan 22, and presents a raft of evidence that the genetic modifications introduced by the mRNA Covid-19 vaccines have diverse consequences to human health.

image-360.png

Source

These include –
  • a potentially direct causal link to neurodegenerative disease;
  • myocarditis;
  • immune thrombocytopenia;
  • Bell’s palsy;
  • liver disease;
  • impaired adaptive immunity;
  • increased production or formation of a tumour or tumours;
  • and DNA damage
A full breakdown of the study can be read here.

It’s a common misconception that Acquired Immunodeficiency Syndrome (AIDS) is only caused by the HIV virus. This simply isn’t true.

Acquired (or secondary) immunodeficiency is one of the major causes of infections in adults. These immunodeficiency disorders affect your immune system partially or as a whole, making your body an easy target for several diseases and infections. (Source)

When immunodeficiency disorders affect your immune system, your body can no longer fight bacteria and diseases. (Source)

Several factors in the environment can cause secondary immunodeficiency disorders. (Source)

Some common ones are:
  • Radiation or chemotherapy, which can lead to a secondary immunodeficiency disorder known as neutropenia
  • Infections due to human immunodeficiency virus (HIV) can result in acquired immune deficiency syndrome (AIDS)
  • Leukaemia, a cancer that begins in the cells of the bone marrow that can lead to hypogammaglobulinemia—a type of secondary immunodeficiency
  • Malnutrition, which affects up to 50% of populations in underdeveloped countries and leaves people vulnerable to respiratory infections and diarrhoea
But some of the less common causes include Drugs or medications. (Source)

So it’s perfectly possible for a medication or drug to cause acquired immunodeficiency syndrome. And the above evidence suggests the Covid-19 injection should be added to the list.

How else do you explain data from the USA showing fifty-one per cent of all adverse reactions associated with AIDS reported since the year 2000 being reported in 2021, and a further 16% being reported in 2022 so far?

image-361.png
Source Data

How else do you explain a 1,919% increase in common cancer associated with AIDS being reported to the U.S. Centers for Disease Control’s Vaccine Adverse Event Reporting System in 2021 compared to the 2000 to 2020 average?

image-362.png
Source Data

Are we really to believe that this is just an unfortunate coincidence? Or are we witnessing the American public report to the Centers for Disease Control that the Covid-19 injections are causing them to develop acquired immunodeficiency syndrome?

Judging by the fact we can’t go a single week without hearing about the re-emergence, or emergence of a disease or ailment, we’re going to go with the latter.

The real-world data does not lie. Something is very wrong, and it is because of the Covid-19 Injections.
 

Heliobas Disciple

TB Fanatic
(fair use applies)

LONG COVID IS A PHENOTYPE OF THE OLDEST OLD INDUCED BY THE SPIKE PROTEIN: AT THE NEXUS OF CACHEXIA AND AMYLOIDOSIS
The Persistence of Spike Protein May NOT be Due to Viral Reservoir: The Spike as Self-Propagating Amyloidogenic Protein
Walter M Chesnut
7 hr ago



THESE ARE THE MOST IMPORTANT WORDS I HAVE YET WRITTEN.

A paper was published on June 14 proving what I have long hypothesized – that the Spike Protein is persistent and circulating in Long COVID. The paper states:
Strikingly, we detect SARS-CoV-2 spike antigen in a majority of PASC patients up to 12 months post-diagnosis, suggesting the presence of an active persistent SARS-CoV-2 viral reservoir.

Persistent circulating SARS-CoV-2 spike is associated with post-acute COVID-19 sequelae

Persistent circulating SARS-CoV-2 spike is associated with post-acute COVID-19 sequelae

What I believe we must consider here is that there MAY BE NO VIRAL RESERVOIR! If the Spike Protein is not cleared (and is it ever actually completely cleared? Is it propagating, prion-like, traveling via extracellular vesicles?) it may be self-propagating, providing its own eternal and ever-expanding “reservoir” within the body.

This may answer the long-standing question as to why people are exhibiting symptoms long after the virus itself has been cleared. We know for a fact that the Spike Protein has amyloidogenic properties, as the now famous paper from Sweden proved.

Amyloidogenesis of SARS-CoV-2 Spike Protein

https://pubs.acs.org/doi/10.1021/jacs.2c03925

Therefore, I believe it is highly likely that the Spike Protein is itself behaving as an amyloid. If so, then there would not need to be any “viral reservoir” as it would be performing as follows:

In a remarkable variety of diseases, specific proteins have been found to misfold and aggregate into seeds that structurally corrupt like proteins, causing them to aggregate and form pathogenic assemblies ranging from small oligomers to large masses of amyloid. Proteinaceous seeds can therefore serve as self-propagating agents for the instigation and progression of disease.

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

So, what is the result of this ever-present invasive protein? CACHEXIA AND AMYLOIDOSIS

CACHEXIA

The paper published June 14 shows that not only was the Spike Protein abundantly present in those with Long COVID, but cytokine levels were also staggeringly high. Extreme elevation of IL-6, TNF-a (among others) was observed.



The presence of the Spike Protein has been proven to induce potent inflammatory cytokines:

We observed that spike (S) protein potently induced inflammatory cytokines and chemokines, including IL-6, IL-1β, TNFα, CXCL1, CXCL2, and CCL2, but not IFNs in human and mouse macrophages.

SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway

SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway

What MUST BE UNDERSTOOD is that it is PRECISELY these cytokines, that when persistently elevated, induce Cachexia. This was proven by a group of researchers at Zhongshan Hospital of Fudan University.

Chronic inflammation, mediated by cytokines such as tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6), has been reported to promote cancer cachexia. we conclude that chronic inflammation (especially that mediated by IL-6) might promote cancer cachexia by regulating WAT lipolysis in early-stage cachexia and browning in late-stage cachexia.

Interleukin-6 induces fat loss in cancer cachexia by promoting white adipose tissue lipolysis and browning

Interleukin-6 induces fat loss in cancer cachexia by promoting white adipose tissue lipolysis and browning - Lipids in Health and Disease

Biomarkers of cancer cachexia

https://www.sciencedirect.com/science/article/abs/pii/S0009912017304277



AMYLOIDOSIS

The second process induced by the Spike Protein present in the oldest old is Amyloidosis.

The Spike Protein has been proven to have VERY STRONG binding affinity to ALL human Amyloid proteins.



It is therefore concluded that:

Stable binding of the S1 protein to these aggregation-prone proteins which might initiates aggregation of brain protein and accelerate neurodegeneration.

SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration

SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration

I reference again the Swedish paper above, to illustrate that not only is this mechanism how the Spike Protein induces
Amyloidosis, but also how it PROPAGATES ITSELF WITHOUT THE PRESENCE OF THE VIRUS.

I wrote posts last year pointing towards this effect. Specifically, ones describing Long COVID as Cancer Metabolism Syndrome, Cancer Without Tumors and Lethal Cancer Phenotype without Primary Tumor.

UNDERSTANDING LONG COVID AS CANCER METABOLISM SYNDROME

UNDERSTANDING LONG COVID AS CANCER METABOLISM SYNDROME – WMC Research

CANCER WITHOUT TUMORS

Cancer Without Tumors – WMC Research

LETHAL CANCER PHENOTYPE WITHOUT PRIMARY TUMOR

THE SPIKE PROTEIN AND THE CANCER SWAMP – WMC Research

There are several questions:

How do we mitigate the presence and potential self-propagating abilities of the Spike Protein?

Does repeated exposure to the Spike Protein, either via infection or vaccination induce and/or accelerate these processes?

How to ensure the world medical and research communities address and investigate these conclusions?

.
 
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Heliobas Disciple

TB Fanatic
(fair use applies)

Pfizer Study Subject C4591001 1162 11621327 ...
Died 2 days After First Dose; Ignored Like Thousands of Other Vaccine Victims

Igor Chudov
6 hr ago

New Pfizer clinical trial documents came out. Here’s just one case: Subject C4591001 1162 11621327.



Subject C4591001 1162 11621327, a 60-year-old white male with a pertinent medical history of obesity (since 2010), traumatic brain injury (in 2011, recovered), depression (since 2011), and hip replacement (in 2015), received Dose 1 or mRNA vaccine on 10 Sep 2020. The subject died of arteriosclerosis on 13 Sep 2020, 3 days after receiving Dose 1. Concomitant medications reported within 2 weeks prior to the onset of arteriosclerosis included venlafaxine hydrochloride (from 2015) and aripiprazole (from 2011), both for depression.

The study site received a police report indicating that the police visited the subject’s home to perform a welfare check on 13 Sep 2020 (Day 4) and found him dead. It was reported that the subject’s body was cold and had visible lividity.
According to the medical examiner, the probable cause of death was progression of atherosclerotic disease. Relevant tests were unknown. Autopsy results were not available at the time of this report. In the opinion of the investigator, there was no reasonable possibility that the arteriosclerosis was related to the study intervention, concomitant medications, or clinical trial procedures, but rather it was related to suspected underlying disease. Pfizer concurred with the investigator’s causality assessment.


Dear Reader: Try to follow this like a Crime TV series. Turn on all your crime scene thinking.

Read this closely: this man lived alone. He was found dead BY POLICE, because of a welfare check request requested by someone. He was found on Day 4 after the shot. He was cold and his skin had lividity. So, a good amount of time passed after his death. Police sent his body to a local medical examiner, who ruled this "to be “arteriosclerosis”.

Did the examiner, who received a routine dead body to examine, have any idea that the dead subject had a Pfizer shot? Obviously, not. So he ruled the death to be due to “arteriosclerosis”, not thinking that this is any type of a special case deserving a closer look.

Did anybody even try to figure out the time of death? Subject C4591001 1162 11621327 was found because of a request for a WELFARE CHECK. So one of his relatives could not get a hold of him for a long time, became worried, possibly consulted other relatives, and eventually contacted the police. Then it took some time for the police to get approval and visit his residence, where he was found dead and cold.

Without knowing much, the deceased possibly was already dead for a couple of days due to the welfare check involved, so he died NOT on Day 4, but perhaps on Day 1 or 2. The report is silent on that obvious point.

What did Pfizer do? Did they request a closer look? Did they ask another examiner for a second opinion? Did they re-examine the deceased? Wouldn’t they want to look closely, if they wanted future recipients of Covid vaccines to be safe?

They did not look closely. The patient died on Sep 13, 2020. The Pfizer report about him was released on Nov 22, 2020. They had plenty of time to at least ask for an examiner’s report. They did not bother to get the report.

They just took the police report’s word that he died of “arteriosclerosis”, stated that Covid Vax cannot cause “arteriosclerosis”, and ruled it “unrelated”. The patient was buried and forgotten.

If I may guess, the examiner’s diagnosis was not even accurate. The medications that the deceased took, indicate no ongoing, severe sclerotic disease. The only medications this patient was taking were depression medications.
Any doctors here wanting to comment?

Who was Subject C4591001 1162 11621327?

He was a lonely overweight 60-year-old white male. He was depressed and probably looked for something to make his life meaningful. When announcements came out for Pfizer's mRNA vaccine study, he possibly signed up because he wanted to contribute to the future of humanity, save us from the terrible virus, and advance science. He had someone, likely a relative, living far away, who cared about him — and that relative actually noticed his silence quickly and called the police for a welfare check. So he probably was an overall good person.

Nobody Died from Covid Vaccine, We Were Told

We were told that nobody died of the vaccine. Subject 4591001 1162 11621327’s death had to be covered up to ensure vaccine uptake and to silence “conspiracy theorists” insisting that the vaccines are deadly.



Subject C4591001 1162 11621327 was like thousands of others, who died from Covid vaccines later. Their deaths had to be covered up, presumably to combat “vaccine hesitancy” and not to give ammunition to those skeptics, like Steve Kirsch and Jessica Rose, who insisted that deaths were covered up. Science demanded silence!

So, they covered Subject C4591001 1162 11621327’s death up. Conspiracy theorists were successfully sidelined. Vaccine uptake was not interrupted, thanks to ignoring the vaccine-caused death of Subject C4591001 1162 11621327. Millions of people received Pfizer’s vaccine believing it was safe and effective and nobody dies from it — and many thousands went on to die. We do not know how many died, because those deaths were also covered up, not reported, or VAERS reports deleted.

Let’s Dream a Little

If Subject C4591001 1162 11621327 did not die, he would probably have his first Covid in 2021. That first Covid would probably be “mild” and he would be thankful for safe and effective vaccines. He’d get a booster afterwards. His second Covid, probably in January of 2022, would be mild also. This man would probably think that with his three shots and two covids, he had pretty good “multilayered immunity”.

The third Covid in June 2022 that Subject C4591001 1162 11621327 could have, if he did not die on Sep 13, 2020, would probably be much worse for him, as it is for a Twitter user Cameron:



Still, his Covids aside, Subject C4591001 1162 11621327 would still be alive, overweight, often chatting on the phone with whoever asked for his welfare check, etc. He was a good person. He wanted to help us. Please give Subject C4591001 1162 11621327 a minute of silence.

Not everything is terrible. There is good news too. Albert Bourla, the CEO of Pfizer, did pretty well for himself.

 

Heliobas Disciple

TB Fanatic
(fair use applies)

'Pandemic babies' with no immunity due to DEATHVAX™ are ending up in intensive care across Australia with respiratory illnesses

2nd Smartest Guy in the World
14 hr ago

The below is just another BigPharma MSM coverup story.

The cause of every single one of these Australian child “RSV infections” which are nothing more than infant VAIDS or iVAIDS is the DEATHVAX™.

2nd Smartest Guy in the World is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

iVAIDS is transferred from bioweapon injected parents to their offspring.

iVAIDS blows out the immune systems of children a la SIDS and VAIDS blows out the immune systems of adults a la SADS.

Over time, as more DEATHVAX™ doses are administered to children from 6 months and older expect parabolic mortality and adverse events.

-----------------------------------------------------------------------------------------------------------
  • Rising number of 'pandemic babies' with no immunity admitted to intensive care
  • Children presenting with 'co-infections' with Covid and other respiratory illness
  • RSV - respiratory syncytial virus - kills 120,000 young children each year globally
  • NSW cases have exploded from 355 a week just three weeks ago to 3775 a week
  • There is no vaccine for RSV but it has almost identical symptoms to flu and Covid
by OLIVIA DAY and KEVIN AIRS FOR DAILY MAIL AUSTRALIA

A concerning number of 'pandemic babies' with no immunity to respiratory viruses are ending up seriously ill in ICU.

Doctors have revealed children born during the Covid-19 pandemic are requiring intensive care 'from encountering viruses they haven't come across before', such as influenza, RSV and Covid.

The children had been born and raised when there were virtually no other viruses circulating in Australia, other than Covid-19.

The Children's Hospital at Westmead infectious diseases paediatrician Dr Philip Britton said an analysis of ICU admissions across shows babies are testing positive for influenza and Covid at the same time.

'Over the last month or so, we have seen four times the admissions to hospital for flu in children as for Covid,' Dr Britton told The Daily Telegraph.

Infectious diseases paediatrician Dr Philip Britton said an analysis of ICU admissions across shows babies are testing positive for influenza and Covid at the same time

Dr Britton said five per cent of the children presenting with co-infections were being admitted to ICU, a statistic he described as 'very concerning'.

About half of the children had no pre-existing health conditions, with the elevated number of admissions putting pressure on the hospital system.

Some of the 'pandemic babies' are presenting with inflammation of the chest, brain and heart caused by influenza, Covid, and RSV.

RSV - respiratory syncytial virus - is a major cause of lung infections in children and can lead to pneumonia or bronchiolitis, which is particularly dangerous in young infants.

Severe cases can kill babies and toddlers, whose tiny airways have not yet fully formed and who struggle to cope with the infection.

'Among that group who are previously well … It's not just a chest infection, some of these children can be impacted with the flu affecting the heart and the brain,' Dr Britton told The Daily Telegraph.

Some of the 'pandemic babies' are presenting with inflammation of the chest, brain and heart caused by influenza, Covid, and RSV.

A warning was sounded about RSV three weeks ago when there were just 355 cases a week in NSW, but three weeks later that has rocketed up to 3,775 in a week.

Around a fifth of those developed the potentially lethal bronchiolitis, with 40 per cent of them ending up in hospital.

Infectious disease researcher Dr John-Sebastian Eden said the triple whammy of RSV, flu and Covid was packing out the emergency department of Sydney's Westmead Children's Hospital.

'There is a widespread three-way outbreak occurring,' he told Daily Mail Australia.

International borders opening up has seen flu come back and new strains of RSV.

'With Covid layered up on top, these are three main viruses which will lead to hospitalisation.'

During Covid, RSV continued to spread and split into two separate strains in the east and west of the country in the wake of Western Australia's prolonged isolation.

Researchers were shocked by the sudden rise of the disease in the first year of lockdowns, fuelled by keeping childcare centres open despite Covid restrictions.

'It was something we had never seen before,' said Dr Eden. 'Even in lockdown there was a lot of effort to keep childcare open.

'You only need a small amount of virus to build up a chain of transmission.'

The disease subsided in 2021, but has now bounced back with the current outbreak.

Dr Eden believes cases in NSW have yet to reach their peak, but is now braced for the outbreak to spread nationwide.

He expects the disease to spread across the southern half of the country at similar levels in the coming weeks.

'What happens is where you have an outbreak in NSW and we've got all those people travelling to other states from there, it then feeds outbreaks in other parts,' he said.

The disease subsided in 2021, but has now bounced back with the current outbreak.

Like Covid, it can be transferred by sneezing and coughing, but unlike Covid, young children are particularly affected by it.

'Most children will recover without needing specialist care in hospital, and children with mild infection can be treated with rest at home,' paediatrician Daniel Yeoh wrote in The Conversation.

'It’s the major cause of lung infections in children, commonly causing bronchiolitis.

'Severe cases occasionally lead to death, predominantly in very young infants.

Almost all children have had an RSV infection by the age of two, but infants in their first year of life are more likely to experience severe infections requiring hospitalisation, because their airways are smaller. Babies have also not built up immunity to RSV from previous years.

Dr Yeoh added: 'Treatment for RSV is focused on helping children with their breathing (for example, giving them oxygen) and feeding (for example, administering fluids through a drip).'

There is no vaccine for RSV but several are under development.
 

Heliobas Disciple

TB Fanatic
(fair use applies)

Australia, oh Australia, what is happening there July 1st 2022? Escalating infections, escalating deaths, 85-90% vaccinated!!! We told you idiots, stop the COVID injection, it is driving infection!
Australia is talking masks again...they will not listen to Geert, or Yeadon, or Bridle, or I, yet they do not yet understand it is the virus-host ecosystem that is driving this; China, et tu? Et tu?
Dr. Paul Alexander
9 hr ago

As you see, infection is not getting back to baseline so will not get to herd immunity. To baseline means we cut the chain of transmission.

It is very simple, with elevated infectious pressure (circulating virus and vaccinating into a pandemic), high vaccine rate (90%), a sub-optimal injection that is non-neutralizing and pressuring the infectiousness of the virus, the spike, then more infectious variants will emerge and as Yahi et al. and other groups have shown (Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination?), the non-neutralizing antibodies bind to the spike but do not eliminate or neutralize the virus and actually enhances/facilitates infection in the vaccinated.

So Australia, tell us again why you think this is happening? And we told you to open up and stop the COVID ZERO lockdowns and school closures, but you laughed at us, called us insane, but you are trapped now. Your nation has little background natural immunity to cope with any new clades and even if the new ones completely bypass natural which it does not, but let us game that out, you are going to cause huge problems for by continuous vaccinating and boosting, you are causing the vaccinated to get infected and some will die. Even if clade BA.5 is more serious, you simply stop the vaccination and you start urgently anti-viral chemoprophylaxis to tame the infectious pressure.

You strongly protect the elderly and vulnerable and go on with life. Do not damage the potent innate immune system of children, it is the key immunological tool to get to herd immunity. Use vit D3 lavishly in your population. If you continue to damage the innate immunity in your population, they will be vulnerable to monkeypox, hepatitis, HIV, EBV, CMV, common colds, COVID, fungal and bacterial infection etc.







Wuhan Sees Virus Return Days After Xi Reinforces Covid Zero

As long as you keep the society in the ZERO COVID lockdown, you will never ever, ever get out of lockdowns China! no background immunity in population. Mark this day I write this. We have told you over and over, use a focused protection, protect the vulnerable, use early treatment, use vitamin D3. The more pressure you place on a highly mutable respiratory virus, the more it will mutate and elude you. You can never get ahead of it. There is also animal reservoir (s) that enable COVID to remain in the environment.

China is in trouble, it does not know what to do, after we showed them for 2.5 years. And has been part of this vaccine fraud so now has played a role in driving the BA.5 variant. Be careful China!
.
 

Heliobas Disciple

TB Fanatic
(fair use applies)

This is what I mean, & Geert means by 'not getting back to baseline' & thus you will never get to herd immunity as you are not cutting the chain of transmission; you see here a curve/wave on left...
gets down to baseline from prior baseline, then you see subsequent curves that on the down side, the slope does not get to baseline, stays up and starts a new wave, that get higher too, no baseline
Dr. Paul Alexander
9 hr ago

Not getting to baseline is critical for it means you are not getting to herd immunity….not cutting the chain of transmission…normally with an outbreak, epidemic etc. you have the rise, peak, then decline back to baseline and you are at herd immunity, it is over; if you do not get to baseline as COVID is behaving especially in omicron, you have massive virus staying in the environment and this is what we mean by heavy infectious pressure…the virus is not going away per wave and the waves just keep getting higher…we are seeing each subsequent peak higher than the prior peak, the curves coming faster (shorter distance between waves), and not getting to baseline. This is a huge problem. This is a new phenomenon in COVID and we are not accustomed to seeing this. Something is not right here and it has to do with the ineffective injection being non-neutralizing and thus not eliminating the virus. Because of this, we cannot get to herd immunity and cannot control this virus if we do not stop the vaccine. Either the vaccine must be stopped or the infectious pressure must be massively reduced. We need less virus around (spike) for the antibodies to place under pressure. It is a simplistic way of stating this but in a nutshell, this is the issue.

The non-neutralizing vaccinal antibodies are causing this. The virus became resistant to the neutralizing antibodies and to the non-neutralizing antibodies. The current omicron virus spike is confronted by the Wuhan spike antibodies (that is gone one year now). How will that work? It cannot. We told these idiots this at PHAC, Health Canada, CDC, NIH, FDA etc. Their response, we vaccinate more. We go after the kids.

They seem incapable of reading the data, do not seem to understand it, do not ‘get’ it, and are cognitively dissonanced as well as academically sloppy. Their polices on COVID have been illogical, irrational, absurd, specious, non-sensical, and purely flat wrong! All! All have failed!

 

Heliobas Disciple

TB Fanatic
(fair use applies)

"US FDA wants COVID boosters targeting Omicron BA.4, BA.5 subvariants"; these technocrat idiots, this morons have leant nothing from all the wrongs they have done & have no idea of viral-host dynamics
FDA, CDC, NIH, HHS, NIAID should all be stripped to the studs, fire top 50 in each agency, investigate all their decisions, including FDA, NIH, CDC, NIAID directors (Francis Collins)
Dr. Paul Alexander
15 hr ago


“The U.S. Food and Drug Administration on Thursday recommended COVID-19 vaccine manufacturers change the design of their booster shots beginning this fall to include components tailored to combat the currently dominant Omicron BA.4 and BA.5 subvariants of the coronavirus.”

SOURCE:

US FDA wants COVID boosters targeting Omicron BA.4, BA.5 subvariants

These idiots are coming with this new plan after we have shown them that key is:

1) you must reduce the infectious pressure; there is too much virus remaining in the environment after each wave and it is not coming down to baseline, thus we are not cutting the chain of transmission so will never get to herd immunity; we need antiviral chemoprophylaxis for the society, antivirals we always had and were urging

2) are these idiots at FDA etc. not grasping that by the time this retooled vaccine is rolled out, that there will be new dominant variants/clades and the vaccine will be akin to how it is now, ‘worthless’? Presently we are using vaccines based on the legacy Wuhan strain when we had Delta and Omicron circulating and Wuhan was long gone.

These bitches at NIH like Collins and Fauci at NIAID et al. had you vaccinating with a vaccine that could have never ever worked and they knew it. The vaccinal antibodies could not hit the omicron variants and they knew. This is why there was immune escape and vaccinated were getting infected. Moreover Yahi et al. has shown us the vaccinal antibodies are so worthless, they are dangerous, for they bind to the target spike antigen (receptor binding domain epitopes on the spike or N terminal domain epitopes) yet do not sterilize (neutralize) the virus and prevent infection. In fact, the binding of non-neutralizing vaccinal antibodies enhances and facilitates infection in the vaccinee, called antibody dependent enhancement of infection (ADEI). There is also pressing original antigenic sin (OAS) where initial exposure imprinting, priming prejudices the subsequent exposure to the initial exposure antibody response, and thus Wuhan antibodies are recalled.

They have greatly disregarded and underestimated the evolutionary capacity of the virus to evolve and adapt to the pressure around it. They deal with this as if based only on the virus’s intrinsic properties and not the environmental pressure and the virus-host immune system interactions. A complex interplay. It is the non-neutralizing antibodies that is the key in this insanity, causing the damage.

3) And now FDA is moving forward on it’s ‘Future Framework’ bullshit garbage corrupted regulatory approach whereby it will use a bi-valent vaccine in the future (omicron spike and Wuhan spike). Once the future COVID vaccines are biologically similar etc., then there is automatic approval, no trials. Now tell me, they are going to approve a vaccine with the Wuhan spike that one year is gone now, worthless, and an Omicron spike that will in time also be displaced. How stupid are they?

4) Do they not get it that in changing the spike antigen target in the vaccine, to make antibodies to that retooled spike, that we will once again be vaccinating into a pandemic, in the midst of high infectious pressure, and with the omicron likely displaced or new clades on tap, then there will be sub-optimal immune pressure again on the spike that will continue to drive infectious variants? How stupid are they. This is what is happening now!

5) Why can’t they, with the vaccine failures now, use an age-risk stratified approach and only target high-risk persons? I say none of these vaccines, but why can’t they? Have they leant nothing?

We know even if this was of utility, they had hundreds of millions of doses of worthless vaccine so kept using it knowing it fails. Now talking ‘retool’. Fire them all!

They do not get it! Will fail again and actually drive humanity altering variants. Likely one that is infectious and lethal at the same time. These bitches know what they are doing. Something dark and malfeasant is at play here. I warn again, I warn again. Not your healthy children.
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Heliobas Disciple

TB Fanatic
(fair use applies)

A Perpetual Pandemic is On the Way Thanks to Planned New COVID-19 Vaccines and FDA's Insanity
FDA will allow Moderna & Pfizer to update the variants targeted by their mRNA injections and require no new studies. What's even more insane? Their "updates" will ensure a Perpetual Pandemic.
James Lyons-Weiler
18 hr ago

Did you know that in their insane new framework, US FDA will allow them to change variants w/no new science?

Also - the new vaccines will include mRNA encoding the original, extinct Wuhan-1 spike protein - ensuring a forever pandemic.

I interviewed Toby Rogers this week for “America Out Loud Pulse” to help him share information on the FDA’s new framework for SARS-CoV-2 strain composition of COVID-19 vaccines. Of all of the outcomes of that meeting, Moderna and Pfizer are being told by our idiotic FDA they update the strain composition to include Omicron, but also that the FDA will

“Recommend that all vaccines used for both primary series and booster doses retain current composition (i.e., Wuhan Spike based)”. (FDA Briefing Document, link below).​

Due to antibody-dependent enhancement (ADE), this will guarantee the continued spread of COVID-19 by the vaccinated.

Importantly, ADE was only studied in animals using vaccine-induced Wuhan-1 spike antibodies and Wuhan-1 viral challenge. Those studies used the wrong animals (Rhesus macaques instead of ferrets), were very small, and Pfizer removed one animal as an “outlier”.

There has not been - because FDA failed to require - any study of ADE caused by Wuhan-1 antibodies from vaccines and challenged by any of the new variants.

And there will not be - because FDA will not NOW require, given their newly adopted “Framework” - which dramatically lowers the regulator bar to “No Science Necessary” - any study of ADE caused by Wuhan-1 antibodies from these new vaccines.

This will ensure the perpetual spread of SARS-CoV-2. All we have to do to understand what Dr. Fantini and his team found to see this is necessarily so:

Fantini made specific claims on a timeline of ADE based on highly accurate molecular modeling that I find most impressive and that I think adds immensely to how solid the knowledge base on ADE. He and his teams’ findings were:
  1. Wuhan-1 Ab vs. Wuhan-1 : No ADE
  2. Wuhan-1 Ab vs. Alpha : No ADE
  3. Wuhan-1 Ab vs. Beta : ADE, but no vaccine at the time
  4. Wuhan-1 Ab vs. Gamma : ADE, but no vaccine at the time
  5. Wuhan-1 Ab vs. Delta + all the rest : ADE and Vaccine-induced ADE
The unavoidable conclusion is that vaccines have driven the pandemic since December, 2020, and now that updated mRNA vaccines will also generate ADE antibodies against Wuhan-1, an extinct variant:

Welcome to Perpetual Pandemic.

My interview with Toby will appear next week on America Out Loud Pulse.



FDA’s Briefing Document​

SARS-CoV-2 strain composition of COVID-19 vaccines

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Heliobas Disciple

TB Fanatic
THERE IS A NEW SUBVARIANT circulating in India right now. They're calling it BA.2.75. It has over 900 percent growth advantage over BA5. It has 16 unique mutations with 8 in the spike protein, 4 in the N Terminal domain, and 4 in the receptor binding domain. I am getting this info from a page that won't let me cut and paste so I can only direct you with a footnote link on that data: BREAKING! India That Spawned The Deadly SARS-CoV-2 Delta Variant Does It Again With A New More Transmissible And Lethal Variant- BA.2.75! - Thailand Medical News

That page did direct me to the following info:

(fair use applies)

BA.2 sublineage with S:K147E, W152R, F157L, I210V, G257S, D339H, G446S, N460K, R493Q (73 seq as of 2022-06-29, mainly India) #773
silcn opened this issue Jun 21, 2022

Proposal for a sublineage of BA.2
Earliest sequence: 2022-06-02 (India)
Countries detected: India (5 seq, from 3 states)

Defining mutations:
S:K147E, W152R, F157L, I210V, G257S, D339H (mutated from G339D), G446S, N460K, R493Q (reversion)
ORF1a:S1221L, P1640S, N4060S
ORF1b:G662S
E:T11A

Don't think much needs to be said to explain why I'm proposing this. Very recent, long branch with 9 new spike mutations, detection in multiple states that aren't all close together (Maharashtra, Karnataka, Jammu and Kashmir). I expect quite a few people have been monitoring it.

Usher tree is a bit messy because of some poor quality sequences, particularly the one from Jammu and Kashmir which has multiple artefactual reversions. As a result this lineage is placed on a branch with a couple of Indian sequences with reversions at S:954 (also probably erroneous - apparent reversions at this site seem to crop up a lot in Indian sequences). Despite what the tree shows, the evidence is currently consistent with all 9 S mutations having appeared on the same long branch. As usual, the 2nt mutation at S:339 is mislabelled.

India_G339H

https://nextstrain.org/fetch/github.com/silcn/subtreeAuspice1/raw/main/auspice/subtreeAuspice1_genome_42b02_161030.json?branchLabel=Spike mutations&c=gt-S_446&label=nuc mutations:C3796T,C3927T,C4586T,C5183T,A12444G,G22577C,G22898A,T22942G,G23040A,A26275G

Genomes:
EPI_ISL_13302209
EPI_ISL_13302252
EPI_ISL_13373059
EPI_ISL_13373170
EPI_ISL_13375776

Edit: cov-spectrum query https://cov-spectrum.org/explore/World/AllSamples/Past6M/variants?variantQuery=[6-of:+S:147E,+S:152R,+S:157L,+S:210V,+S:257S,+S:339H,+S:446S,+S:460K,+ORF1a:1221L,+ORF1a:1640S,+ORF1a:4060S]&
Missing some sequences that only have a month of collection


FROM THE COMMENTS:

silcn commented Jun 21, 2022
Now found in Germany: EPI_ISL_13378378, EPI_ISL_13378924
And also in Canada: EPI_ISL_13392500
EPI_ISL_13389935 is another Indian sequence, with NNNs covering the locations of all the S mutations but it shares all the non-S mutations.

silcn commented Jun 22, 2022

More Indian sequences: EPI_ISL_13409385, EPI_ISL_13409444, EPI_ISL_13409465

FedeGueli mentioned this issue Jun 27, 2022
BA.2 sublineage with S:69/70del, S:E340K, S:K356T, S:L452R, S:R493Q, S:D936H (26 seq as of 2022-07-01, Ireland/various European countries/US) #732
[my comment - I can't change that :D because it's a hotlink, it still works, it automatically does that when it see : and D in order]


silcn commented Jun 28, 2022
Among the 20 new BA.2.75 uploads from Maharashtra today is an apparent outlier sequence, EPI_ISL_13502528, which has S:147E, 210V, 257S, 339H, 493Q and ORF1a:1221L but is missing the other defining mutations and instead has some more of its own (none in Spike though). It is classified as BA.2 rather than BA.2.75 by Usher. If this spreads then it could potentially deserve a separate designation; I'll keep looking out for more.
Another of the new Maharashtra sequences (EPI_ISL_13502546) has S:681R and ORF8:27* - something else to keep an eye on...

silcn commented Jun 28, 2022
Among the 20 new BA.2.75 uploads from Maharashtra today is an apparent outlier sequence, EPI_ISL_13502528, which has S:147E, 210V, 257S, 339H, 493Q and ORF1a:1221L but is missing the other defining mutations and instead has some more of its own (none in Spike though). It is classified as BA.2 rather than BA.2.75 by Usher. If this spreads then it could potentially deserve a separate designation; I'll keep looking out for more.
Another of the new Maharashtra sequences (EPI_ISL_13502546) has S:681R and ORF8:27* - something else to keep an eye on...


shay671 commented Jun 30, 2022
Here is the case count by country/region for the 53 cases i found yesterday.
IndiaHaryana3
Himachal Pradesh3
Jammu and Kashmir1
Karnataka10
Maharashtra23
GermanyBaden-Wurttemberg1
Rhineland-Palatinate1
UKEngland5
CanadaAlberta1
Ontario1
AustraliaVictoria2
New Zeland2

FedeGueli commented Jun 30, 2022

@karyakarte consider that there are multiple sub lineages of potential nterest, designated, proposed or unproposed, emerged first and now circulating in India. I cannot weigh how much of the apparent growth advantage is due to these sublineages keeping BA.5 to lower levels than outside of India or due to intrinsic BA.2.75 advantage that cant be ruled out or affirmed with certainty yet.

karyakarte commented Jul 1, 2022
@FedeGueli I totally agree. Sequencing coordinated by our center of 1698 isolates of May and June 2022 show BA.2 (48.62%), BA.2.12.1 (2.41%), BA.2.38 (39.33%), BA.4 (1.20%), BA.5 (3.11%) (with negligible numbers of other BA.2 sub-lineages making a total of 100%). This shows the reason for my earlier comment 10 hours back. that maybe some other lineage currently classified as BA. sub-lineage is growing. In our last run at BJGMC, Pune we found BA.2.74 and BA.2.75 that was red-flagged. Hence, we re-run Fasta available with us, with adequate coverage, at UShER. The results showed that a number of BA.2 turning out to be BA.2.74/BA.2.75. Hence, this issue is highlighted at appropriate fora with following comments, "Request to urgently re-run fasta on UShER again particularly samples from end of May and entire June.

The predominance of BA.2 on a waning wave was unexplainable. May be it is BA.2.74/BA.2.75 - with more than 80 mutations. A new designation for these variants seems essential, otherwise epidemiological response is blunted." We need to look into the matter @silcn @corneliusroemer @thomasppeacock @chrisruis @AngieHinrichs.

silcn commented Jul 1, 2022
Regarding BA.2 lineages in India: Japan just uploaded 42 sequences from travellers from India, sampled from 27 May to 16 June, which might give a more representative sample given the differences in sequencing quantity across India. Here is the lineage breakdown according to Usher:
17 BA.2.38 (of which 1 is #809)
15 BA.2 (of which 8 are #787, 2 have S:L452M but are not BA.2.56, and 1 has S:R346T+S:L452M but is not BA.2.74)
4 BA.2.56
2 BA.2.74
1 BA.2.75
1 miscellaneous BA.1/BA.2 recombinant
1 BA.4
1 BA.5.2
I agree with the comments in that thread that there is a very strong case for designating #787.
 
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psychgirl

Has No Life - Lives on TB
I don’t understand a word of their conversation in that virology forum lol ….but I’m assuming its not good.
 

Heliobas Disciple

TB Fanatic
There are 3 twitter threads about this but they have images that won't copy over so I'll only post the first post from the twitter thread, please go over to each thread to read more. There are multiple posts with images.

View: https://twitter.com/RajlabN/status/1542866412904976384
Raj Rajnarayanan @RajlabN

Greater than Titan! Seems like BA.2.75 has the potential to outcompete BA.5*/BA.4* and other circulating BA.2 lineages Early days but growth advantage will be clear in a couple of weeks.


View: https://twitter.com/PeacockFlu/status/1542501382678147072
Tom Peacock @PeacockFlu

Surveillence minded folks - worth keeping a close eye on BA.2.75 - lots of spike mutations, probable second generation variant, apparent rapid growth and wide geographical spread...


View: https://twitter.com/jbloom_lab/status/1542526099287969792
Bloom Lab@jbloom_lab
Jun 30

This new #SARSCoV2 Omicron subvariant (BA.2.75) flagged here by @PeacockFlu is worth tracking, as it has appreciable antigenic change relative to its parent BA.2. Key mutations: G446S & R493Q Here is summary of what those mutations imply for antibody escape & ACE2 affinity (1/n)
 
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Heliobas Disciple

TB Fanatic
I don’t understand a word of their conversation in that virology forum lol ….but I’m assuming its not good.

I don't understand most of it either, but it has a lot of mutations and is up and coming. So it might be a candidate for what Geert said to watch out for and worth paying attention to if more info comes out about it. Ahead of the curve, that's what we are on this thread ;)

HD
 

psychgirl

Has No Life - Lives on TB
That one guy above, his name is Raj…on his Twitter link he shows a graph of the United States listing hot spots, y state, for new infections…it goes right along with what a friend of mine in Texas is saying!
She lives there in the San Antonio area and is currently really sick.
Her first time with Covid.
She said they have 900 new cases in Texasit’s all over the place.
 

Zoner

Veteran Member
Thanks HD for the postings. They are trying to come up with a booster for BA5 available in September and new variants are breaking out NOW so what good will those booster shots be? They will actually hurt people instead of helping them.

I don't know the science they are talking about on your post on the variant spawning from India. India is also where Delta spawned from. Makes me wonder if it's natural or planted in India because of the huge population and wide global travel of Indians. But this variant is no doubt in the U.S. already and like Psychgirl said, this could be the strain in Texas. Only antivirals can help us now...so stock up.
 
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