Medical **** Flu Season *** Aleve to the Rescue - ????

[Illini Warrior]

x
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https://prepschooldaily.blogspot.com...u-already.html

"A few years back as I was eating lunch, I came across an article suggesting that naproxen sodium (Aleve) could be a valuable OTC pharmaceutical in treating influenza. It's cool an intriguing idea, even if it hasn't undergone clinical trials yet. It's really worth knowing and won't cost you any extra money. And because it's so potentially valuable, being as it's the beginning of flu season and all that, it's worth mentioning again.

Not only that, the researchers also found that naproxen was more effective than oseltamivir (Tamiflu) in mice. And naproxen is more effective against influenza B than influenza A. (If the flu viruses would now just identify themselves when they infect, that would be super helpful.)

The authors conclude, "If naproxen is an effective anti-influenza drug for humans, it could be implemented into influenza treatment protocols more quickly than other antivirals in development."

In a nutshell, their preliminary research shows that Aleve is more effective than Tamiflu. In mice. Like the disclaimer above says, I'm not a doctor and this isn't medical advice. You need to talk to your doctor before using any medication."



For further reading:
https://www.sciencedirect.com/scienc...261?via%3Dihub
Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection: An Open-label Randomized, Controlled, Phase IIb/III Trial - PubMed

 

[psychgirl]

Thank you for finding and posting this information!
If true, wow!

 

[patriotgal]

NSAIDS like Naprosyn can give you bleeding stomach ulcers. Was on rx strength once for something. Cured the something but then had to cure the ulcer.

 

[nomifyle]

I am hesitant to take Naprosyn, it was prescribed to me by an ortho several years ago for a shoulder injury and I took it like it was prescribed. It gave me serious mouth ulcers. I asked the nurse in Ortho about it and she said she'd never heard of it but to keep taking it. I went to a bookstore on Canal street and saw a Peoples Pharmacology book and looked it up and one of the first side effects was mouth ulcers. I quit taking it.

If I got really sick with the flu I'd take it for a very limited amount of time. I've been taking Diclofanac (NSAID) for my knee recently but I've stopped. No stomach issues, thank God.

 

[inskanoot]

There’s melatonin.

3. CONCLUSIONS​

Overall, commonly affected processes in viral infections would suggest that the lack of an available vaccine and antiviral, and their impotence in the face of new viral mutations, should not necessarily lead to a management response that is solely dependent upon social isolation in order to decrease human mortality.

A number of factors can act to inhibit the key cellular changes upon which viruses act, with melatonin being one such factor. The utility of melatonin is paradoxically under‐appreciated, if not suppressed, by its ready availability, low cost, and very high safety profile.

At the time of writing, there has been a significant impact of covid‐19 on global economies. It would seem inappropriate to wait for the pharmaceutical companies to provide a targeted antiviral and vaccine in over a year's time, at which point covid‐19 may well have mutated.

As highlighted throughout, viral impacts on human physiology allows for the use of nutriceuticals and pharmaceuticals that may lower infection severity by targeting physiological processes. Melatonin is one such substance. Melatonin is actively inhibited by most viruses, indicating its importance in the regulation of viral infections.

A further benefit of melatonin in the management of influenza and covid‐19 arises from its utility in management of the array of preexisting medical conditions associated with viral‐linked fatality. The potential benefits of sodium butyrate in the management of influenza and covid‐19 infections include its immune suppressive and mitochondrial optimization effects as well as its induction of the melatonergic pathway and ability to decrease the gut permeability that is associated with high risk preexisting medical conditions.

Overall, there are biomedical, financial, and moral reasons for developing and testing interventions that may immediately limit the impact of viral infections.

Melatonin: Roles in influenza, Covid‐19, and other viral infections

There is a growing appreciation that the regulation of the melatonergic pathways, both pineal and systemic, may be an important aspect in how viruses drive the cellular changes that underpin their control of cellular function. We review the melatonergic ...

www.ncbi.nlm.nih.gov

 

[Illini Warrior]

There’s melatonin.

3. CONCLUSIONS​

Overall, commonly affected processes in viral infections would suggest that the lack of an available vaccine and antiviral, and their impotence in the face of new viral mutations, should not necessarily lead to a management response that is solely dependent upon social isolation in order to decrease human mortality.

A number of factors can act to inhibit the key cellular changes upon which viruses act, with melatonin being one such factor. The utility of melatonin is paradoxically under‐appreciated, if not suppressed, by its ready availability, low cost, and very high safety profile.

At the time of writing, there has been a significant impact of covid‐19 on global economies. It would seem inappropriate to wait for the pharmaceutical companies to provide a targeted antiviral and vaccine in over a year's time, at which point covid‐19 may well have mutated.

As highlighted throughout, viral impacts on human physiology allows for the use of nutriceuticals and pharmaceuticals that may lower infection severity by targeting physiological processes. Melatonin is one such substance. Melatonin is actively inhibited by most viruses, indicating its importance in the regulation of viral infections.

A further benefit of melatonin in the management of influenza and covid‐19 arises from its utility in management of the array of preexisting medical conditions associated with viral‐linked fatality. The potential benefits of sodium butyrate in the management of influenza and covid‐19 infections include its immune suppressive and mitochondrial optimization effects as well as its induction of the melatonergic pathway and ability to decrease the gut permeability that is associated with high risk preexisting medical conditions.

Overall, there are biomedical, financial, and moral reasons for developing and testing interventions that may immediately limit the impact of viral infections.

Melatonin: Roles in influenza, Covid‐19, and other viral infections

There is a growing appreciation that the regulation of the melatonergic pathways, both pineal and systemic, may be an important aspect in how viruses drive the cellular changes that underpin their control of cellular function. We review the melatonergic ...

www.ncbi.nlm.nih.gov

I think we covered COVID and melatonin already >>>> Prep School Daily

 

[Kathy in FL]

Naproxen is about the only thing I can take OTC to help with my arthritic feet (part hereditary and part my own fault). I take one in the morning and that's it. I could take another twelve hours later but I generally don't unless there is a weather change or something else going on.

I also found that if I have a fever that Tylenol is faster to relieve the fever but naproxen keeps it gone longer. Both require a constant consumption of fluids and you need to have something on your stomach, even if it is just broth.

However, everyone is different. What I have found that works for me may not work for others. My parents cannot take naproxen according to their docs due to other medications they take. Find that kind of stuff out now. Contraindications between medications are nothing to fool with.

 

[inskanoot]

I think we covered COVID and melatonin already >>>> Prep School Daily

It’s your thread.

I thought that the reference to a study about the safety and effectiveness of melatonin for influenza might be helpful, especially for people who won’t or can’t take products like Aleve and are frantically dealing with the “flu season”.

 

[SouthernBreeze]

IIRC, if a person has any liver or kidney issues, Aleve isn't for them. My dad developed chronic kidney disease from taking prescription Naproxen for several years for his arthritis. Mom can't take Naproxen, because she has an autoimmune liver disease.

 

[Wildwood]

It’s your thread.

I thought that the reference to a study about the safety and effectiveness of melatonin for influenza might be helpful, especially for people who won’t or can’t take products like Alleve and are frantically dealing with the “flu season”.

I'm glad you brought it up. I'm allergic to Aleve and while melatonin has been discussed extensively for covid, it still bears repeating. However, if it's been discussed for influenza, I missed it.

Even though I can't take it, I keep Aleve on hand all the time for my big dogs and for the rest of my family who can take it. They rarely reach for it though.

 

[FireDance]

You really MUST eat something when you take a NSAID of any type. Otherwise, it WILL tear up your gut.

I occasionally take one without eating, but occasional is the operative word. Usually I have at least a snack of some type.

If I am taking it daily for some reason I try to take them around mealtime for real protection.

I had a C-section and was surprised that the naproxen worked a heck of a lot better than the morphine I had in hospital.

I consider it a “good drug” but you have to really take care of your gut. And I would only take it daily if I had to and probably not more than a week. Again, everyone is different, so you have to watch it and make sure you can tolerate it.

Thank you for the info on all this. Quite interesting!!

 

[kyrsyan]

My dislike for naproxen is that it is a 12 hour dose. If it doesn't work, you aren't supposed to take other NSAIDS for 12 hours. So while it's in my medicine cabinet, I don't use it frequently.

 

[Snettrecker]

naproxen is more effective against influenza B than influenza A.

All we're seeing in western NC is flu A, so if you're in that region, just a heads up.

 

[Cag3db1rd]

I think we covered COVID and melatonin already >>>> Prep School Daily

I'm glad it was mentioned here as I missed out on a lot of covid discussions.

They rarely reach for it though.

They don't have opposable thumbs. They're dogs.

 

[Wildwood]

I'm glad it was mentioned here as I missed out on a lot of covid discussions.

They don't have opposable thumbs. They're dogs.

LOL, I see what you did there.

 

[Babs]

I am hesitant to take Naprosyn, it was prescribed to me by an ortho several years ago for a shoulder injury and I took it like it was prescribed. It gave me serious mouth ulcers. I asked the nurse in Ortho about it and she said she'd never heard of it but to keep taking it. I went to a bookstore on Canal street and saw a Peoples Pharmacology book and looked it up and one of the first side effects was mouth ulcers. I quit taking it.

If I got really sick with the flu I'd take it for a very limited amount of time. I've been taking Diclofanac (NSAID) for my knee recently but I've stopped. No stomach issues, thank God.

That happened to me, but Nexium was the culprit.

 

[etdeb]

Naproxen is about the only thing I can take OTC to help with my arthritic feet (part hereditary and part my own fault). I take one in the morning and that's it. I could take another twelve hours later but I generally don't unless there is a weather change or something else going on.

I also found that if I have a fever that Tylenol is faster to relieve the fever but naproxen keeps it gone longer. Both require a constant consumption of fluids and you need to have something on your stomach, even if it is just broth.

However, everyone is different. What I have found that works for me may not work for others. My parents cannot take naproxen according to their docs due to other medications they take. Find that kind of stuff out now. Contraindications between medications are nothing to fool with.

I have found almonds are the best thing i can keep handy to make sure to have something on my stomach
I am not a breakfast person but meds and supplements make me nauseous so 3 or 4 almonds just before taking stops that.

 

[ReneeT]

Thanks for the info, Illini Warrior