Cytokine storms - Why they are dangerous and can kill
Click this link to find the regimen to prevent and cure influenza diseases and cytokine storms >
http://sites.google.com/site/influe...-storms---why-they-are-dangerous-and-can-kill
You can print this page and show your doctor. Under any circumstances you should read this page carefully.
The most serious complication in relation to serious influenza illness is the virus' ability to spark a cytokine storm after the infection has subsided - especially in young, healthy individuals this is seen as the primary cause when influenza illnesses results in death or serious illness. The cytokine storm is per se an after-effect caused by the virus.
What are cytokines?
Cytokines are a group of signalling substances the body uses to communicate internally. It is essential for the cells in the immune system to communicate and coordinate immune activity in the defense and repair of damage to the body. Cytokines kan be expressed by normal tissue cells to communicate with the immune system, but primarily cytokines are used by the immune system. So far more than 25 cytokines has been mapped but the knowledge about these substances and their importance in regulating the body's various functions is steadily growing.
Cytokines is a collective term for a long serious of signalling substances - like interpherones (IFN) that play a crucial role in signalling to the body's immune system that something is wrong in relation to a detection of a viral agent, bacterial agent, fungal agent or cancer cells (which actually is produced all the time, but normally killed by a healthy immune system). In addition to interferons there is a big group of cytokins known as Interleukines (IL), for instance IL-1, IL-2, IL-3 etc. One other important cytokine is Tumor Necrosis Factor (TNF) and as the name describes it is a substances that among other things kills cancer cells (tumors). This is however just one effect of TNF. An over expression of TNF is seen in numerous auto-immune diseases hwere the body's immune system attacks the body itself. One example is rheumatic diseases.
Some of the the key cytokines can be seen represented by these beautiful macromolecular models underneath. Read more about cytokines, cytokine storms and how to treat them further down.
How do I know if I am suffering from a cytokine storm?
Some of the syptoms of a cytokine storm is clearly felt but you need a medical doctor to determin the diagnosis. A cytokine storm manifests itself as follows:
Typically after a few days of influenza (flu) like illness (depending on which strain of virus) when you should be recovering - you suddenly feel worse. The transition from a common influenza illness to a cytokine storm can be sudden or there can be a smooth transition. That is why it is important to get diagnosed by a doctor! As an example there were numerous accounts during the 1918-1919 pandemic that patients got extremely ill in the morning and passed away the same night. The illness caused an estimated nearly 50 million deaths, however the lethality was no more than 5%. Nevertheless amny of those who died, died of "the black lung" disease, caused by a cytokine storm which caused hemorrhage to the lungs - thus it became know as "the black lung" disease.
Symptoms of a cytokine storm can be:
You need a doctor to evaluate these symptoms.
How can a cytokine storm be stopped?
I the beginning of an H1N1 outbrak in the body the virus will stimulate the production of a long series of cytokines. The key cytokines expressed are IL-1, IL-6 and TNF. These cytokins are vital to the body's ability to combat the viral infection. Towards the end of the illness the normal response of the body's immune system is to give a signal by IL-10. This normally reduces the activity of the immune system and guides the body into a phase of restitution. In persons with a strong immune system there are sometimes given a too strong signal of IL-10. This leads to a misinterpretation by the immune system and it is interpreted as a signal to engage "in force". In stead of reducing the cytokine expression the immune system dramatically increases the cytokine production mores specifically IL-1, IL-6 and TNF. This causes a severe immune reaction in, for instance lung tissue, and the result is pulmonary embolism and pulmonary oedema (ARDS).
This publication may be printed and presented to your doctor.
Not all medical doctors know the method on how to stop a cytokine storm. The most common conventional treatment of a cytokine storm is to try using a cortical steroid and some may even try an antiviral medication - with no effect since this concerns the aftermath of the viral infection in the immunesystem and not the viral infection itself. The problem of a cytokine storm is a "derailing" of the immune system. When the immune system no longer has a viral agent to combat the battle is instead causing severe damage to the body.
There are three central substances in stopping a cytokine storm.
Eicosapentaenic Acid (EPA) - this superunsaturated fatty acid is present in fat fish from cold waters, seal- and whale oils. A high quality supplement of one of these oils should be taken as a supplement prior to the disease (super unsaturated fatty acids like EPA is essential to modulate the immune system, regulate auto-immune diseases, promote normal growth, development and function of the body and especially the central nervous system). See the page of how to prevent respiratory infections like the flu virus.
Curcumin - is a substance found in large quantaties in the spice Turmeric. This substance should NOT be taken before or during influenza illnesses as it possibly in some cases can contribute to developing a cytokine storm!
NSAID - more specifically acetylic salicylic acid NSAID - Non-Steroidal Anti-Inflammatory Drug - This is an huge group of medicines. One of the best known brands is Aspirin. WARNING! This substance should NOT be taken before or during influenza illnesses as it most likely in some cases can contribute to developing a cytokine storm!
Curcumin should not be taken before or during an influenza illness. These substances should only be used if your doctor has diagnosed a cytokine storm!
These three substances have a very complex action in the body. The main action is blocking NF-kB - NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells - This important fast transcription factor was discovered by the Nobel Laureate in Medicine David L. Baltimore.
These substances work by partly blocking this rapid transcription factor in the genetic material in a type of white blood cells known as B-lymphocytes and partly by stimulating the production of anti-inflammatory prostaglandins - which is a tissue hormone that reduces inflammation.
<table style="border-color:rgb(136,136,136);border-width:1px;border-collapse:collapse" border="1" cellspacing="0"> <tbody> <tr> <td style="width:60px">
</td> <td style="width:60px">
</td> </tr> <tr> <td style="width:60px">NF-kB - seen from above curled around a strain of DNA (seen in the middle as a "wheel hub")</td> <td style="width:60px"> NF-kB - seen from the side with the well know double helix structure of DNA in the center. </td> </tr> </tbody> </table>
You will find the explanation to each substance and dose below. These substances can block a cytokine storm. It is extremely important that you take the vitamins, minerals and superunsaturated fatty acids found here to avoid developing the cytokine storm in the first place. You can find the nutritional supplements guide by clicking here.
Substances described and dose to treat a cytokin storm
<table style="border-color:rgb(136,136,136);border-width:1px;margin:0px;border-collapse:collapse" border="1" cellspacing="0"> <tbody> <tr> <td style="padding:1px 4px;vertical-align:top;width:24px;height:19px"> </td> <td style="padding:1px 4px;vertical-align:top;width:186px;height:19px"> Substance</td> <td style="padding:1px 4px;vertical-align:top;width:122px;height:19px">Dose</td> <td style="padding:1px 4px;vertical-align:top;width:867px;height:19px">Comments
</td> </tr> <tr> <td style="padding:1px 4px;vertical-align:top;width:24px;height:518px"> 3</td> <td style="padding:1px 4px;vertical-align:top;width:186px;height:518px">"E M E R G E N C Y BREAK"
These substances is used to stop a cytokine storm. These substances should NOT be used prior to or during influenza illness since they seriously can affect the immun system and may even trigger a cytokine storm (except the omega-3 fatty acid EPA). You need a medical doctor to diagnose a cytokine stom before taking curcumin and NSAIDs like acetylic salicylic acid!
</td> <td style="padding:1px 4px;vertical-align:top;width:122px;height:518px">To the doctor >>>>
</td> <td style="padding:1px 4px;vertical-align:top;width:867px;height:518px">IMPORTANT! Always consult your doctor before taking Curcumin and NSAID (i.e. acetylic salicylic acid - Aspirin). If these substances are taken prior to or during influenza illness they may make the infection more severe by weakening the immun system and even trigger a cytokine storm!
Turmeric/Curcumin and NSAID (like i.e. Aspirin) should never be taken before or during an influenza illness. These substances constitues an emergency break that you can pull when your doctor has diagnosed a cytokine storm. When such a diagnosis is made, it is absolutely crucial that you take these medicines as soon as possible. This is an "emergency break" to be used in patients with a strong and otherwise healthy immune system.
Typically a cytokine storm manifests itself at the end or immediately after an influenza illness. Curcumin and Acetylic Salicylic Acid or other NSAID should not be used by persons with a weakened immune system or with an ongoing infection, unless this is deem absolutely necessary by a physician. Children should never use NSAID because of the risk of developing Reye's Syndrome.
Print this page and show your doctor. You should always discuss tratment with Turmeric or NSAIDs with your physician and explain the following principles:
In the beginning of an Influenza Virus attack, the virus will stimulate the body to express numerous cytokines. Key cytokines are IL-1, IL-6 and TNF. These cytokines are vital in the defense against the infection. Towards the end of the illness the body will under normal circumstances give a moderate signal of IL-10 that normally reduces the high state of alert in the immune system and guides the body into a phase of restitution. In persons (typically adolesent and young adults) there is sometimes given a too strong signal of IL-10. This leads the immune system to go into overdrive and instead of a reduction in proinflammatory cytokine expression there is a storm of cytokin expression by especially IL-1, IL-6 and TNF. This cytokine storm could lead to complications like pulmonary embolism and pulmonary oedema (ARDS).
Curcumin (diferuloylmethane) is a substance found in large quantities in the spice Turmeric (Curcuma longa). Curcumin is a strong inhibitor of NF-kB<sup>1, 2, 3, 4, 5,6</sup> and will efficiently block a cytokine storm. You can find a meta-article (draft) explaining the various biological effects of curcumin by clicking this link <sup>6</sup>.
Acetylic Salicylic Acid (and other NSAIDs) can contribute to blocking a cytokin storm by inhibiting the enzyme Cyclooxygenase-2 from producing inflammatory prostaglandins (eicosanoids and lipoxins). Acetylic Salicylic Acid also blocks NF-kB. Children should not take NSAIDs because of the risk of developing Reye's Syndrome. Pregnant women should not be taking NSAIDs.
A lot of people have raised concern about taking NSAIDs at all. One alternative is taking a high quality wild fatty fish oil from polar regions, seal or whale oil in large quantaties (approximately 2 tablespoons a day). This has the same effect as taking NSAIDs but with far less both short and long term side-effects. NSAIDs causes cardiovascular diseases when used over a prolonged series of time (blocking COX-1 and COX-2 in the endothelial cells of coronary arteries induces a more rapid formation of plaque in these arteries), while large doses of superunsaturated fatty acids prevents cardiovascular disease and modulates auto-immune diseases like i.e. psoriasis and rheumatic diseases. It is however necessary that these oils are cold pressed and purified (from fat-soluble environmental toxins). One supplier of such high quality oils is Urtekompaniet AS in Narvik, Norway.
The Omega-3 superunsaturated fatty acid EPA<sup>7</sup> is converted through the COX-2 enzyme system to antiinflammatory prostaglandins. Contrary to some claims during the media frenzy of the so-called 2009-pandemic where marine Omega-3 Fatty Acids was said to be dangerous in relation to the Influenza A H1N1 2009-pandemic. There is no danger whatsoever in taking these fatty acids. In fact taking these fatty acids prior to the influenza along with the right vitamin and mineral supplements in the correct dose will block Influenza Illnesses in the first place, and in the unlikely event that you should fall ill, being well supplemented by these fatty acids will prevent a development of a cytokin storm. We have had NO reports of anyone getting ill by Influenza while on this regimen!
Marine Omega-3 Fatty Acids are extremely important regulators of the immune system. They are necessary to prevent cardiovascular diseases (as long as they are cold pressed high quality with a low fraction of trans-fatty acids). There are hypothesis on these fatty acids contributing to preventing cancer. They have shown to be important to regulate blood sugar and regulate the metabolism. They are necessary for the proper regulation in growth and development and recent studies have shown that they are absolutely necessary for cells in the Nervous System to function properly and cope with stress. In fact patients with psychiatric disorders has shown to have extremely low levels of these important fatty acids.
Between 2% and 10% of the worlds population carries a mutation that makes it necessary for them to get these fatty acids from marine animals as they can not convert vegetable oils.
The three substances mentioned above are quite simple but the synergistic effect in the correct dose will effectively block cytokine storms in a patient. An ounce of prevention is worth a ton of cure! Preventing the illness in the first place is the gold standard strategy. This can easily with very few side-effects be achieved by the orthomolecular regimen, and some of the "side-effects" by this regimen is a reduction in cancer incidence, a reduction in cardiovascular incidence and improved performance by neurons in the CNS.
In the case where no such profylactic regimen has been followed - and a patient is presented with a cytokine storm - the three substances mentioned above is key to reducing the current H1N1-pandemic - and other influenza illnesses - to diseases with no deaths.
Links - please look at the end of this document
</td> </tr> <tr> <td style="padding:1px 4px;vertical-align:top;width:24px;height:95px"> 3.1</td> <td style="padding:1px 4px;vertical-align:top;width:186px;height:95px">Only to be used in the case of a properly diagnosed cytokine storm:
Turmeric Curcuma longa
;)
</td> <td style="padding:1px 4px;vertical-align:top;width:122px;height:95px">Approx. 1 capsule Solaray Curcumin (285 milligram curcumin) 3 times a day. The dose may be double for one day under the supervision of a medical doctor.
</td> <td style="padding:1px 4px;vertical-align:top;width:867px;height:95px">Approximately 10 gram of Turmeric rhizoma (root-stalk) 3 times a day for 3 days in relation to a properly diagnosed cytokine storm. This may sound strange but approximately 3% of Turmeric consists of the polyphenol curcumin, and thus this simple spice has a potent effect.
Solaray Curcumin contains 285 mg curcumin per capsule which means you would only need to take 1 capsule 3 times a day for 3 days.
For further information on the effect of curcumin read the entire article!
Should not be taken by people with weakened immune system or ongoing infection.
This substance should not be taken unless your doctor has made the diagnose cytokine storm.
</td> </tr> <tr> <td style="padding:1px 4px;vertical-align:top;width:24px;height:127px"> 3.2</td> <td style="padding:1px 4px;vertical-align:top;width:186px;height:127px">Only to be used in the case of a properly diagnosed cytokine stormAspirin (other NSAIDs)
</td> <td style="padding:1px 4px;vertical-align:top;width:122px;height:127px">Dose must be determined by your doctor after he has made the diagnosis cytokin storm!</td> <td style="padding:1px 4px;vertical-align:top;width:867px;height:127px">Aspirin or similar NSAIDs inhibits the action of COX-2 to produce proinflammatory prostaglandins. Thus there are more antiinflammatory prostaglandins produced.
This along with turmeric/curcumin and the EPA and DHA superunsaturated omega-3 fatty acids blocks a cytokine storm that in healthy young individuals with a strong immune system could prove to be deadly.
NSAIDs should not be used by children because of the risk of developing Reye's Syndrome. NSAIDs should not be taken by pregnant women. Talk to your doctor og pharmacist and/or read the leaflet and/or warnings on the package. Should not be used by persons with a weak immune system. Should not be used on the onset of Influenza Like Illness but only when properly diagnosed with an actual cytokin storm. If taken to early these substances may promote the spreading of the virus in your body.
You should always have a Medical Doctor diagnose a cytokine storm properly prior to taking NSAIDs.
</td> </tr> <tr> <td> 3.3</td> <td>Should be taken prior to the infection
Eicosapentaoenic Acid (EPA)
Should be taken prior to the infection
Docosahexaenoic Acid (DHA)
</td> <td>Approximately 2 tablespoons of pure high quality marine oils (not cod-liver oil!)
</td> <td>Both EPA and DHA has shown the ability to block NF-kB, and thus - in addition to the two substances described above - these fatty acids will help block a cytokin storm. EPA and DHA modulates the immunactivity prior to an infection and is as such a vital part in the orthomolecular regimen.
One supplier of such high quality oils is Urtekompaniet AS in Narvik, Norway.
</td> </tr> </tbody> </table>
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References (being updated)
1. http://www.jbc.org/content/270/42/24995.abstract
2. http://www.liebertonline.com/doi/abs/10.1089/10762800360520776
3. http://www.sciencedirect.com/scienc...serid=10&md5=3784f3635bc5d380fdb3ec9f4b787dda
4. http://www.sciencedirect.com/scienc...serid=10&md5=7603a6c283e57de30b8f96b54c83e603
5. http://www.ncbi.nlm.nih.gov/pubmed/16715036
6. http://www.indsaff.com/10 Curcumin biological.pdf
7. http://www.ncbi.nlm.nih.gov/pubmed/19202383
Illustrations in this article is curtesy of Wikimedia Commons.
<hr size="2" width="100%"> DISCLAIMER
No information on this website may exclude consulting your doctor. In case of illness including one or more of these symptoms high fever, swelling and redness, extreme fatigue and/or nausea, do not hesitate in contacting your doctor or the nearest hospital! Medical doctors trained in orthomolecular medicine have very good skills in treating infectious diseases.
Several doctors have orthomolecular training. I highly recommend:
Claus Hancke - Klinikksjef ved Institut for Orthomolekylær medicin, Kgs. Lyngby, Danmark - En av Nordens ledende på området ortomolekylær medisin.
Bruce Kyle - Lege og leder av Århus Privatklinikk, Århus Danmark
Use of information given on this website is at your own responsibility. Author(s) of this site can not be held responsible for the use or misuse of the information given here or injury caused by such use or misuse of this information. All advices are given based on the principals of orthomolecular treatment.
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Dedicated to Amy H. for the inspiration to bringing out this knowledge to the world in an easy to understand fashion in English.
Click this link to find the regimen to prevent and cure influenza diseases and cytokine storms >
http://sites.google.com/site/influe...-storms---why-they-are-dangerous-and-can-kill
You can print this page and show your doctor. Under any circumstances you should read this page carefully.
The most serious complication in relation to serious influenza illness is the virus' ability to spark a cytokine storm after the infection has subsided - especially in young, healthy individuals this is seen as the primary cause when influenza illnesses results in death or serious illness. The cytokine storm is per se an after-effect caused by the virus.
What are cytokines?
Cytokines are a group of signalling substances the body uses to communicate internally. It is essential for the cells in the immune system to communicate and coordinate immune activity in the defense and repair of damage to the body. Cytokines kan be expressed by normal tissue cells to communicate with the immune system, but primarily cytokines are used by the immune system. So far more than 25 cytokines has been mapped but the knowledge about these substances and their importance in regulating the body's various functions is steadily growing.
Cytokines is a collective term for a long serious of signalling substances - like interpherones (IFN) that play a crucial role in signalling to the body's immune system that something is wrong in relation to a detection of a viral agent, bacterial agent, fungal agent or cancer cells (which actually is produced all the time, but normally killed by a healthy immune system). In addition to interferons there is a big group of cytokins known as Interleukines (IL), for instance IL-1, IL-2, IL-3 etc. One other important cytokine is Tumor Necrosis Factor (TNF) and as the name describes it is a substances that among other things kills cancer cells (tumors). This is however just one effect of TNF. An over expression of TNF is seen in numerous auto-immune diseases hwere the body's immune system attacks the body itself. One example is rheumatic diseases.
Some of the the key cytokines can be seen represented by these beautiful macromolecular models underneath. Read more about cytokines, cytokine storms and how to treat them further down.
<table style="border-color:rgb(136,136,136);border-width:1px;border-collapse:collapse" border="1" cellspacing="0"> <tbody> <tr> <td style="width:60px">
</td> <td style="width:60px">
</td> <td style="width:60px">
</td> <td style="width:60px">
</td> <td style="width:60px">
</td> </tr> <tr> <td style="text-align:center;width:60px">Recombinant Human Interferon </td> <td style="text-align:center;width:60px"> Interleukin 1
IL-1</td> <td style="text-align:center;width:60px"> Interleukin 6
IL-6</td> <td style="text-align:center;width:60px"> Interleukin 10
IL-10</td> <td style="text-align:center;width:60px"> TNF-alfa</td> </tr> </tbody> </table>
IL-1</td> <td style="text-align:center;width:60px"> Interleukin 6
IL-6</td> <td style="text-align:center;width:60px"> Interleukin 10
IL-10</td> <td style="text-align:center;width:60px"> TNF-alfa</td> </tr> </tbody> </table>
How do I know if I am suffering from a cytokine storm?
Some of the syptoms of a cytokine storm is clearly felt but you need a medical doctor to determin the diagnosis. A cytokine storm manifests itself as follows:
Typically after a few days of influenza (flu) like illness (depending on which strain of virus) when you should be recovering - you suddenly feel worse. The transition from a common influenza illness to a cytokine storm can be sudden or there can be a smooth transition. That is why it is important to get diagnosed by a doctor! As an example there were numerous accounts during the 1918-1919 pandemic that patients got extremely ill in the morning and passed away the same night. The illness caused an estimated nearly 50 million deaths, however the lethality was no more than 5%. Nevertheless amny of those who died, died of "the black lung" disease, caused by a cytokine storm which caused hemorrhage to the lungs - thus it became know as "the black lung" disease.
Symptoms of a cytokine storm can be:
- Hypotension (rapidly falling/low blood pressure)
- Tachycardia (rapid pulse, more than 100 beats per minute)
- Dyspnea (difficulty breathing)
- Fever (temperature higher than 38°C/100°F)
- Ischemia (restriction of bloodflow, especially to the internal organs)
- Organ failure (as a result of the lack of oxygen, acidosis and severe failure of the metabolism)
- Uncontrollable hemorrhage - in relation to influenza, thypically of lung and airway tissue
You need a doctor to evaluate these symptoms.
How can a cytokine storm be stopped?
I the beginning of an H1N1 outbrak in the body the virus will stimulate the production of a long series of cytokines. The key cytokines expressed are IL-1, IL-6 and TNF. These cytokins are vital to the body's ability to combat the viral infection. Towards the end of the illness the normal response of the body's immune system is to give a signal by IL-10. This normally reduces the activity of the immune system and guides the body into a phase of restitution. In persons with a strong immune system there are sometimes given a too strong signal of IL-10. This leads to a misinterpretation by the immune system and it is interpreted as a signal to engage "in force". In stead of reducing the cytokine expression the immune system dramatically increases the cytokine production mores specifically IL-1, IL-6 and TNF. This causes a severe immune reaction in, for instance lung tissue, and the result is pulmonary embolism and pulmonary oedema (ARDS).
This publication may be printed and presented to your doctor.
Not all medical doctors know the method on how to stop a cytokine storm. The most common conventional treatment of a cytokine storm is to try using a cortical steroid and some may even try an antiviral medication - with no effect since this concerns the aftermath of the viral infection in the immunesystem and not the viral infection itself. The problem of a cytokine storm is a "derailing" of the immune system. When the immune system no longer has a viral agent to combat the battle is instead causing severe damage to the body.
There are three central substances in stopping a cytokine storm.
Eicosapentaenic Acid (EPA) - this superunsaturated fatty acid is present in fat fish from cold waters, seal- and whale oils. A high quality supplement of one of these oils should be taken as a supplement prior to the disease (super unsaturated fatty acids like EPA is essential to modulate the immune system, regulate auto-immune diseases, promote normal growth, development and function of the body and especially the central nervous system). See the page of how to prevent respiratory infections like the flu virus.
Curcumin - is a substance found in large quantaties in the spice Turmeric. This substance should NOT be taken before or during influenza illnesses as it possibly in some cases can contribute to developing a cytokine storm!
NSAID - more specifically acetylic salicylic acid NSAID - Non-Steroidal Anti-Inflammatory Drug - This is an huge group of medicines. One of the best known brands is Aspirin. WARNING! This substance should NOT be taken before or during influenza illnesses as it most likely in some cases can contribute to developing a cytokine storm!
Curcumin should not be taken before or during an influenza illness. These substances should only be used if your doctor has diagnosed a cytokine storm!
These three substances have a very complex action in the body. The main action is blocking NF-kB - NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells - This important fast transcription factor was discovered by the Nobel Laureate in Medicine David L. Baltimore.
These substances work by partly blocking this rapid transcription factor in the genetic material in a type of white blood cells known as B-lymphocytes and partly by stimulating the production of anti-inflammatory prostaglandins - which is a tissue hormone that reduces inflammation.
<table style="border-color:rgb(136,136,136);border-width:1px;border-collapse:collapse" border="1" cellspacing="0"> <tbody> <tr> <td style="width:60px">
You will find the explanation to each substance and dose below. These substances can block a cytokine storm. It is extremely important that you take the vitamins, minerals and superunsaturated fatty acids found here to avoid developing the cytokine storm in the first place. You can find the nutritional supplements guide by clicking here.
Substances described and dose to treat a cytokin storm
<table style="border-color:rgb(136,136,136);border-width:1px;margin:0px;border-collapse:collapse" border="1" cellspacing="0"> <tbody> <tr> <td style="padding:1px 4px;vertical-align:top;width:24px;height:19px"> </td> <td style="padding:1px 4px;vertical-align:top;width:186px;height:19px"> Substance</td> <td style="padding:1px 4px;vertical-align:top;width:122px;height:19px">Dose</td> <td style="padding:1px 4px;vertical-align:top;width:867px;height:19px">Comments
</td> </tr> <tr> <td style="padding:1px 4px;vertical-align:top;width:24px;height:518px"> 3</td> <td style="padding:1px 4px;vertical-align:top;width:186px;height:518px">"E M E R G E N C Y BREAK"
These substances is used to stop a cytokine storm. These substances should NOT be used prior to or during influenza illness since they seriously can affect the immun system and may even trigger a cytokine storm (except the omega-3 fatty acid EPA). You need a medical doctor to diagnose a cytokine stom before taking curcumin and NSAIDs like acetylic salicylic acid!
</td> <td style="padding:1px 4px;vertical-align:top;width:122px;height:518px">To the doctor >>>>
</td> <td style="padding:1px 4px;vertical-align:top;width:867px;height:518px">IMPORTANT! Always consult your doctor before taking Curcumin and NSAID (i.e. acetylic salicylic acid - Aspirin). If these substances are taken prior to or during influenza illness they may make the infection more severe by weakening the immun system and even trigger a cytokine storm!
Turmeric/Curcumin and NSAID (like i.e. Aspirin) should never be taken before or during an influenza illness. These substances constitues an emergency break that you can pull when your doctor has diagnosed a cytokine storm. When such a diagnosis is made, it is absolutely crucial that you take these medicines as soon as possible. This is an "emergency break" to be used in patients with a strong and otherwise healthy immune system.
Typically a cytokine storm manifests itself at the end or immediately after an influenza illness. Curcumin and Acetylic Salicylic Acid or other NSAID should not be used by persons with a weakened immune system or with an ongoing infection, unless this is deem absolutely necessary by a physician. Children should never use NSAID because of the risk of developing Reye's Syndrome.
Print this page and show your doctor. You should always discuss tratment with Turmeric or NSAIDs with your physician and explain the following principles:
In the beginning of an Influenza Virus attack, the virus will stimulate the body to express numerous cytokines. Key cytokines are IL-1, IL-6 and TNF. These cytokines are vital in the defense against the infection. Towards the end of the illness the body will under normal circumstances give a moderate signal of IL-10 that normally reduces the high state of alert in the immune system and guides the body into a phase of restitution. In persons (typically adolesent and young adults) there is sometimes given a too strong signal of IL-10. This leads the immune system to go into overdrive and instead of a reduction in proinflammatory cytokine expression there is a storm of cytokin expression by especially IL-1, IL-6 and TNF. This cytokine storm could lead to complications like pulmonary embolism and pulmonary oedema (ARDS).
Curcumin (diferuloylmethane) is a substance found in large quantities in the spice Turmeric (Curcuma longa). Curcumin is a strong inhibitor of NF-kB<sup>1, 2, 3, 4, 5,6</sup> and will efficiently block a cytokine storm. You can find a meta-article (draft) explaining the various biological effects of curcumin by clicking this link <sup>6</sup>.
Acetylic Salicylic Acid (and other NSAIDs) can contribute to blocking a cytokin storm by inhibiting the enzyme Cyclooxygenase-2 from producing inflammatory prostaglandins (eicosanoids and lipoxins). Acetylic Salicylic Acid also blocks NF-kB. Children should not take NSAIDs because of the risk of developing Reye's Syndrome. Pregnant women should not be taking NSAIDs.
A lot of people have raised concern about taking NSAIDs at all. One alternative is taking a high quality wild fatty fish oil from polar regions, seal or whale oil in large quantaties (approximately 2 tablespoons a day). This has the same effect as taking NSAIDs but with far less both short and long term side-effects. NSAIDs causes cardiovascular diseases when used over a prolonged series of time (blocking COX-1 and COX-2 in the endothelial cells of coronary arteries induces a more rapid formation of plaque in these arteries), while large doses of superunsaturated fatty acids prevents cardiovascular disease and modulates auto-immune diseases like i.e. psoriasis and rheumatic diseases. It is however necessary that these oils are cold pressed and purified (from fat-soluble environmental toxins). One supplier of such high quality oils is Urtekompaniet AS in Narvik, Norway.
The Omega-3 superunsaturated fatty acid EPA<sup>7</sup> is converted through the COX-2 enzyme system to antiinflammatory prostaglandins. Contrary to some claims during the media frenzy of the so-called 2009-pandemic where marine Omega-3 Fatty Acids was said to be dangerous in relation to the Influenza A H1N1 2009-pandemic. There is no danger whatsoever in taking these fatty acids. In fact taking these fatty acids prior to the influenza along with the right vitamin and mineral supplements in the correct dose will block Influenza Illnesses in the first place, and in the unlikely event that you should fall ill, being well supplemented by these fatty acids will prevent a development of a cytokin storm. We have had NO reports of anyone getting ill by Influenza while on this regimen!
Marine Omega-3 Fatty Acids are extremely important regulators of the immune system. They are necessary to prevent cardiovascular diseases (as long as they are cold pressed high quality with a low fraction of trans-fatty acids). There are hypothesis on these fatty acids contributing to preventing cancer. They have shown to be important to regulate blood sugar and regulate the metabolism. They are necessary for the proper regulation in growth and development and recent studies have shown that they are absolutely necessary for cells in the Nervous System to function properly and cope with stress. In fact patients with psychiatric disorders has shown to have extremely low levels of these important fatty acids.
Between 2% and 10% of the worlds population carries a mutation that makes it necessary for them to get these fatty acids from marine animals as they can not convert vegetable oils.
The three substances mentioned above are quite simple but the synergistic effect in the correct dose will effectively block cytokine storms in a patient. An ounce of prevention is worth a ton of cure! Preventing the illness in the first place is the gold standard strategy. This can easily with very few side-effects be achieved by the orthomolecular regimen, and some of the "side-effects" by this regimen is a reduction in cancer incidence, a reduction in cardiovascular incidence and improved performance by neurons in the CNS.
In the case where no such profylactic regimen has been followed - and a patient is presented with a cytokine storm - the three substances mentioned above is key to reducing the current H1N1-pandemic - and other influenza illnesses - to diseases with no deaths.
Links - please look at the end of this document
</td> </tr> <tr> <td style="padding:1px 4px;vertical-align:top;width:24px;height:95px"> 3.1</td> <td style="padding:1px 4px;vertical-align:top;width:186px;height:95px">Only to be used in the case of a properly diagnosed cytokine storm:
Turmeric Curcuma longa
</td> <td style="padding:1px 4px;vertical-align:top;width:867px;height:95px">Approximately 10 gram of Turmeric rhizoma (root-stalk) 3 times a day for 3 days in relation to a properly diagnosed cytokine storm. This may sound strange but approximately 3% of Turmeric consists of the polyphenol curcumin, and thus this simple spice has a potent effect.
Solaray Curcumin contains 285 mg curcumin per capsule which means you would only need to take 1 capsule 3 times a day for 3 days.
For further information on the effect of curcumin read the entire article!
Should not be taken by people with weakened immune system or ongoing infection.
This substance should not be taken unless your doctor has made the diagnose cytokine storm.
</td> </tr> <tr> <td style="padding:1px 4px;vertical-align:top;width:24px;height:127px"> 3.2</td> <td style="padding:1px 4px;vertical-align:top;width:186px;height:127px">Only to be used in the case of a properly diagnosed cytokine stormAspirin (other NSAIDs)
</td> <td style="padding:1px 4px;vertical-align:top;width:122px;height:127px">Dose must be determined by your doctor after he has made the diagnosis cytokin storm!</td> <td style="padding:1px 4px;vertical-align:top;width:867px;height:127px">Aspirin or similar NSAIDs inhibits the action of COX-2 to produce proinflammatory prostaglandins. Thus there are more antiinflammatory prostaglandins produced.
This along with turmeric/curcumin and the EPA and DHA superunsaturated omega-3 fatty acids blocks a cytokine storm that in healthy young individuals with a strong immune system could prove to be deadly.
NSAIDs should not be used by children because of the risk of developing Reye's Syndrome. NSAIDs should not be taken by pregnant women. Talk to your doctor og pharmacist and/or read the leaflet and/or warnings on the package. Should not be used by persons with a weak immune system. Should not be used on the onset of Influenza Like Illness but only when properly diagnosed with an actual cytokin storm. If taken to early these substances may promote the spreading of the virus in your body.
You should always have a Medical Doctor diagnose a cytokine storm properly prior to taking NSAIDs.
</td> </tr> <tr> <td> 3.3</td> <td>Should be taken prior to the infection
Eicosapentaoenic Acid (EPA)
Should be taken prior to the infection
Docosahexaenoic Acid (DHA)
</td> <td>Approximately 2 tablespoons of pure high quality marine oils (not cod-liver oil!)
</td> <td>Both EPA and DHA has shown the ability to block NF-kB, and thus - in addition to the two substances described above - these fatty acids will help block a cytokin storm. EPA and DHA modulates the immunactivity prior to an infection and is as such a vital part in the orthomolecular regimen.
One supplier of such high quality oils is Urtekompaniet AS in Narvik, Norway.
</td> </tr> </tbody> </table>
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References (being updated)
1. http://www.jbc.org/content/270/42/24995.abstract
2. http://www.liebertonline.com/doi/abs/10.1089/10762800360520776
3. http://www.sciencedirect.com/scienc...serid=10&md5=3784f3635bc5d380fdb3ec9f4b787dda
4. http://www.sciencedirect.com/scienc...serid=10&md5=7603a6c283e57de30b8f96b54c83e603
5. http://www.ncbi.nlm.nih.gov/pubmed/16715036
6. http://www.indsaff.com/10 Curcumin biological.pdf
7. http://www.ncbi.nlm.nih.gov/pubmed/19202383
Illustrations in this article is curtesy of Wikimedia Commons.
<hr size="2" width="100%"> DISCLAIMER
No information on this website may exclude consulting your doctor. In case of illness including one or more of these symptoms high fever, swelling and redness, extreme fatigue and/or nausea, do not hesitate in contacting your doctor or the nearest hospital! Medical doctors trained in orthomolecular medicine have very good skills in treating infectious diseases.
Several doctors have orthomolecular training. I highly recommend:
Claus Hancke - Klinikksjef ved Institut for Orthomolekylær medicin, Kgs. Lyngby, Danmark - En av Nordens ledende på området ortomolekylær medisin.
Bruce Kyle - Lege og leder av Århus Privatklinikk, Århus Danmark
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