CORONA COVID vaccines do not ‘shed’ from one person to another and then cause reproductive problems

Cardinal

Chickministrator
_______________

By Reuters Fact Check
9 MIN READ

False claims that the coronavirus vaccines can be passed – or “shed” – from an immunized person to an unvaccinated woman and then somehow affect the woman’s reproductive system are whipping around social media. Top medical experts agree that it is impossible for a person to transmit the vaccines to people they happen to be near and for a woman to experience miscarriage, menstrual cycle changes, and other reproductive problems by being around a vaccinated person.

“This is a conspiracy that has been created to weaken trust in a series of vaccines that have been demonstrated in clinical trials to be safe and effective,” said Dr Christopher Zahn, Vice President for Practice Activities at the American College of Obstetricians and Gynecologists, the leading U.S. organization for medical professionals in women’s healthcare.

Calling the vaccines “our single best tool for confronting a global pandemic that has taken 600,000 lives in this country alone,” Zahn added in a statement emailed to Reuters that “such conspiracies and false narratives are dangerous and have nothing to do with science.”

Posts such as those found here, here , here , here , and here falsely claim that vaccine “shedding” may cause a variety of reproductive problems and that women should avoid associating with vaccinated people.


instagram-image-CN3hJIGhfwb

instagram-image-CNxdXkpnVaZ

Many posts also state that receiving vaccine shots can interfere with menstruation, citing anecdotes about women who have been vaccinated. Researchers are currently investigating the anecdotes, and at this time Reuters cannot assess the validity of the claims.


The term “shed” was used frequently in the early days of the pandemic to describe people transmitting or emitting coronavirus particles. Scientists measure “viral shedding” to try to pinpoint at what point sick people are the most infectious ( here ).

“There is no way for a COVID-19 vaccinated person to “shed vaccine,” the Centers for Disease Control’s COVID-19 Clinical Team said in an email responding to Reuters questions.

“COVID-19 vaccines give instructions to teach our cells how to make a protein—or even just a piece of a protein—that triggers an immune response inside our bodies. After the protein piece is made, the cell breaks down the instructions and gets rid of them. The immune response, which produces antibodies, is what protects us from getting infected if the real virus enters our bodies.”

The team also stated the vaccines cannot cause people to shed the COVID-19 virus, echoing all the other experts Reuters spoke to, saying “COVID-19 vaccines do not use the live virus that causes COVID-19 and cannot cause COVID-19. Therefore, people who receive a COVID-19 vaccine cannot shed the virus or the vaccine.”

Many of the false posts attribute the “shedding” of vaccines to a “spike protein” in an apparent misunderstanding of how the vaccines work.

The mRNA vaccines “contain only instructions for making spike protein and are incapable of generating virus particles, so nothing can be shed,” said Dr Daniel Kuritzkes, chief of the infectious diseases division at Brigham and Women’s Hospital, one of the world’s top teaching hospitals and part of Harvard Medical School, in a statement emailed to Reuters.

Likewise, the Johnson & Johnson (also referred to as Janssen) vaccine “is based on a replication-defective adenovirus, which means the adenovirus is incapable of reproducing,” he added.

As Reuters explained here the Pfizer-BioNTech and Moderna COVID-19 vaccines use a chemical messenger, or mRNA, to tell people’s cells to make “make proteins that mimic the outer surface of SARS-CoV-2 (the virus that causes COVID-19)…without replicating like the actual virus.” Meanwhile, the J&J vaccine uses a “weakened version of a harmless adenovirus to deliver instructions to cells to make coronavirus spike proteins” that also cannot replicate, as Reuters reported here .


Kuritzkes also pointed out that the mRNA vaccines are degraded within 24 to 48 hours. As explained here , that means they disappear from the shot recipients’ bodies within a day or two. Similarly, the J&J vaccine “gets taken up into cells where it is injected, makes spike protein, and is degraded. It cannot disseminate to other tissues or be shed,” Kuritzkes said.

The New York Times illustrates in detail how that vaccine works here .

The Food and Drug Administration and Centers for Disease Control and Prevention (CDC) have recommended a pause in the J&J vaccine while they investigate six cases of a rare blood clot in six women who received it ( here ).

Looking at research and data on the coronavirus and vaccinations, the National Institutes of Health have not found vaccine “shedding.” The NIH, the world’s largest biomedical research agency ( www.nih.gov/about-nih ), continues to advise that people remain cautious about the coronavirus itself, even when around vaccinated people. It recommends vaccinated individuals continue to wear masks, practice physical distancing and use other measures to reduce the spread of the virus, given that there are cases of people who have been infected even after being fully vaccinated.

“There is no evidence that individuals vaccinated for COVID-19 can transmit the vaccines to others or that vaccination of one person can have negative health effects on others,” said an NIH spokesperson in a statement emailed to Reuters.

More research is needed to assess the posts claiming that receiving a vaccine shot can disrupt a woman’s period.

The clinical trials for the three vaccines approved for emergency use in the United States did not look into possible issues related to menstruation as seen here, here and here .

A January 2021 study found that COVID-19 infections affected some people’s menstrual volume and cycle length ( here ). But there aren’t any studies to illuminate recent anecdotes on social media about earlier periods, heavier flows and more painful cramps related to vaccinations ( here).


The Vaccine Adverse Event Reporting System managed by the CDC and Food and Drug Administration wonder.cdc.gov/vaers.htmlhas received reports of menstrual cycle changes.

Kathryn Clancy, a University of Illinois Urbana-Champaign associate professor in anthropology, and a fellow researcher are conducting an on-line survey here about the relationship between COVID-19 vaccines and menstruation that has received thousands of responses ( here ).

Still, Dr Miriam Laufer, Professor of Pediatrics, Medicine, Epidemiology and Public health at the University of Maryland School of Medicine, said “the vaccine does not impact the hormones that are responsible for a woman’s menstrual cycle.”

VERDICT
False. It is impossible to “shed” the coronavirus vaccine. Being around vaccinated people cannot hurt a woman’s reproductive system.

This article was produced by the Reuters Fact Check team. Read more about our work to fact-check social media posts here  .
 

Coulter

Veteran Member
“This is a conspiracy that has been created to weaken trust in a series of vaccines that have been demonstrated in clinical trials to be safe and effective,” said Dr Christopher Zahn, Vice President for Practice Activities at the American College of Obstetricians and Gynecologists, the leading U.S. organization for medical professionals in women’s healthcare.

Calling the vaccines “our single best tool for confronting a global pandemic that has taken 600,000 lives in this country alone,” Zahn added in a statement emailed to Reuters that “such conspiracies and false narratives are dangerous and have nothing to do with science.”



I have no clue what the answer is - but her credibility with me is zero.
 

summerthyme

Administrator
_______________
One cannot “catch” a vaccine. Thinking otherwise is, frankly, insane.
Not quite accurate... "modified live" vaccines *definitely* can cause mild infection. There are some vaccines for various respiratory viruses that can not be given to a pregnant cow, or one nursing a calf... she will abort, or the calf will develop the disease they were vaccinating for. They use killed virus vaccines for those animals.

But since the current shots are NOT "vaccines" by the standard legal definition, and they contain NO whole virus in any form... dead, live or weakened live... they *can't * spread COVID. Its certainly possible for the freshly vaccinated person to come down with COVID- or even died from it, because there is always a time factor for vaccines to start working effectively.

When we showed cows, we always timed their shipping fever and other required vaccinations to be *finished* by at least 2 weeks before we were planning on loading up. Since we always vaccinated the entire herd in the fall for respiratory viruses, as well as leptospirosis, it meant just giving a booster to most. But calves had to have two doses (initial vaccination almost always requires a booster or second dose to complete the immunization process). So, we made sure to time it right.

But most people don't understand the details, and its obvious most think these shots are no different than the flu vaccine or pneumonia vaccine. But they ARE different... very different. And while they have *less* risk of certain problems (such as bringing home modified live virus that then infects a family member who is immune impaired), their known risks of potentially serious health problems are significantly higher than the risk from the flu vaccine.

An example of a vaccine that uses a modified live virus and they warn you to stay away from "vulnerable " people for a period of time (a couple weeks, IIRC) after getting the shot is the "Flu-Mist nasal vaccine.

Summerthyme
 
Not quite accurate... "modified live" vaccines *definitely* can cause mild infection. There are some vaccines for various respiratory viruses that can not be given to a pregnant cow, or one nursing a calf... she will abort, or the calf will develop the disease they were vaccinating for. They use killed virus vaccines for those animals.

But since the current shots are NOT "vaccines" by the standard legal definition, and they contain NO whole virus in any form... dead, live or weakened live... they *can't * spread COVID. Its certainly possible for the freshly vaccinated person to come down with COVID- or even died from it, because there is always a time factor for vaccines to start working effectively.

When we showed cows, we always timed their shipping fever and other required vaccinations to be *finished* by at least 2 weeks before we were planning on loading up. Since we always vaccinated the entire herd in the fall for respiratory viruses, as well as leptospirosis, it meant just giving a booster to most. But calves had to have two doses (initial vaccination almost always requires a booster or second dose to complete the immunization process). So, we made sure to time it right.

But most people don't understand the details, and its obvious most think these shots are no different than the flu vaccine or pneumonia vaccine. But they ARE different... very different. And while they have *less* risk of certain problems (such as bringing home modified live virus that then infects a family member who is immune impaired), their known risks of potentially serious health problems are significantly higher than the risk from the flu vaccine.

An example of a vaccine that uses a modified live virus and they warn you to stay away from "vulnerable " people for a period of time (a couple weeks, IIRC) after getting the shot is the "Flu-Mist nasal vaccine.

Summerthyme
But I read that the mRNA can be spread thru kissing or sex. I read a post not here that a guy said his girlfriend got the vaccine and he didn't , but 2 weeks after having sex with her he got a full body rash. So maybe one cant get it from being near someone. But I still wonder about sex and kissing and especially blood transfusions....
 

Dennis Olson

Chief Curmudgeon
_______________
Not quite accurate... "modified live" vaccines *definitely* can cause mild infection. There are some vaccines for various respiratory viruses that can not be given to a pregnant cow, or one nursing a calf... she will abort, or the calf will develop the disease they were vaccinating for. They use killed virus vaccines for those animals.

But since the current shots are NOT "vaccines" by the standard legal definition, and they contain NO whole virus in any form... dead, live or weakened live... they *can't * spread COVID.
You’ve misunderstood. The hysteria is about passing the mRNA VACCINE ITSELF to others. Not Covid.
 

Dennis Olson

Chief Curmudgeon
_______________
But I read that the mRNA can be spread thru kissing or sex. I read a post not here that a guy said his girlfriend got the vaccine and he didn't , but 2 weeks after having sex with her he got a full body rash. So maybe one cant get it from being near someone. But I still wonder about sex and kissing and especially blood transfusions....
You need to stay off GLP.
 
I just saw a video on Bitchute: "Warning!! The Vaccinated Are Shedding Spike Proteins That Attack Reproductive Organs".
I disagree with those who say there is no shedding! Watch the video. Seee: Bitchute.com/videoRWbykjjHaVf/
 

Dennis Olson

Chief Curmudgeon
_______________
I just saw a video on Bitchute: "Warning!! The Vaccinated Are Shedding Spike Proteins That Attack Reproductive Organs".
I disagree with those who say there is no shedding! Watch the video. Seee: Bitchute.com/videoRWbykjjHaVf/
Disagree all you want. The entire premise is insane.
 

inskanoot

Veteran Member
Clif High has offered some opinions on this subject, and has offered some conflicting comments in recent bitchutes. Last I looked, he didn‘t provide links for science-y cites. These vids are on two other threads.

He mentioned that non-vaccinated women experienced alarming menses after reacting to pheromones from vaccinated women.

He also mentioned men having rashes in their privates. At least one of these men developed the rash after sex with a vaccinated woman.

He said that the spike protein separates from and outlives other portions of the vaccine, and that the spike protein is more dangerous when this happens. He also said that the human body routinely sheds proteins. The good and the bad of the spike protein shedding is that the body does everything it can to get rid of the suckers, ASAP.

I am offering this as food for thought, only. I don’t find it necessary to believe everything that I read and think about.
 

inskanoot

Veteran Member
But I read that the mRNA can be spread thru kissing or sex. I read a post not here that a guy said his girlfriend got the vaccine and he didn't , but 2 weeks after having sex with her he got a full body rash. So maybe one cant get it from being near someone. But I still wonder about sex and kissing and especially blood transfusions....

Technically, sexual activity is an immunological event.
 

Breeta

Veteran Member
it’s not shedding virus. It’s shedding radioactivity which works in tandem with 5G. / sorry, been digging deep in the woo hole lately. lol. That’s what “shedding” is about though...
 

TammyinWI

Talk is cheap

TammyinWI

Talk is cheap

I almost posted a nice summary and a video about this report from infowars, but TB2K still censors that website, right?
Johns Hopkins report about the desirability of a self-spreading vaccine. Insanity? Or evil?

Yeah, I am confounded right now, and followed your link. I do wish that a summary was available, as I am not in the mood to sift through all of it...maybe later. Did someone else write a synopsis? TIA.

Part of the reason I am so blah is that one of my relatives that said they would not get "the vax" showed up with a funny slight yellowish complexion, and I knew, before even asking that they had got the shot. I had the thought come to me before meeting them that they did, for some odd reason, like a premonition.

They had gotten the first one, after being adamant for all this time to NOT take one.

Now I have to avoid this person, as i do not want to be around someone who took even one.
 

inskanoot

Veteran Member
Yeah, I am confounded right now, and followed your link. I do wish that a summary was available, as I am not in the mood to sift through all of it...maybe later. Did someone else write a synopsis? TIA.

Part of the reason I am so blah is that one of my relatives that said they would not get "the vax" showed up with a funny slight yellowish complexion, and I knew, before even asking that they had got the shot. I had the thought come to me before meeting them that they did, for some odd reason, like a premonition.

They had gotten the first one, after being adamant for all this time to NOT take one.

Now I have to avoid this person, as i do not want to be around someone who took even one.

Page 8 of Exec Summary: Self-Spreading Vaccines: Self-spreading vaccines are genetically engineered to move through populations like communicable diseases, but rather than causing disease, they confer protection. The vision is that a small number of individuals in a target population could be vaccinated, and the vaccine strain would then circulate in the population much like a pathogenic virus, resulting in rapid, widespread immunity.

Pages 45 - 47:

What is the technology?

Self-spreading vaccines—also known as transmissible or self-propagatingvaccines—are genetically engineered to move through populations in the same way as communicable diseases, but rather than causing disease, they confer
protection. The vision is that a small number of individuals in the target population could be vaccinated, and the
vaccine strain would then circulate in the population much like a pathogenic virus. These vaccines could dramatically increase vaccine coverage in human or animal populations without requiring each individual to be inoculated. This technology is currently aimed primarily at animal populations. Because most infectious diseases are zoonotic,40 controlling disease in animal populations would also reduce the risk to humans.

There are 2 main types of self-spreading vaccines: recombinant vector vaccines and live viral vaccines. Recombinant vector vaccines combine the elements of a pathogenic virus that induce immunity (removing the portion that causes disease) with a transmissible viral vector. Cyto- megalovirus is one candidate vector for recombinant vaccines, because
it is highly species-specific and moderately transmissible. Live viral vaccines are attenuated, meaning that the vaccine viruses are much less pathogenic than wild-type and would be similar to the oral polio vaccine or the live attenuated influenza vaccine (LAIV) in that those vaccines can sometimes transmit from person to person.

Although there are substantial technical challenges in genetically engineering viruses, synthetic biology tools such as CRISPR/Cas9 are likely to aid researchers in overcoming these hurdles in the coming years. Self-spreading vaccines have already been used to protect wild rabbits from myxomatosis and to control
Sin Nombre virus in rodent populations. Additional work is targeting Ebola virus in apes and bats, Lassa virus in rats, and bovine tuberculosis in badgers

What problem does this solve?


The most practical and useful application of self-spreading vaccines would be to control disease spread in wild animal populations (also known as sylvatic spread). A vaccine would be administered to a few selected animals in hotspots among target populations including nonhuman primates, bats, or rodents. The vaccine would then spread within the target
population, eliminating the need to vaccinate each animal. Successful disease control in animal populations could limit the number of infected animals and thereby reduce the opportunity for the disease to spill over into humans, thus stopping outbreaks in humans before they ever emerge. Such a sylvatic strategy would reduce the overall number of outbreak opportunities in humans, but it could not interrupt an outbreak once it becomes established in humans.

In the event of a grave public health threat, self-spreading vaccines could potentially be used to broadly inoculate human populations. Like the approach in animals, only a small number of vaccinated individuals would be required in order to confer protection to a larger susceptible population, thus eliminating the need for mass vaccination operations, including PODs.

self-spreading vaccines
45

medical
Countermeasure
distribution, dispensing,
and administration


46


How do we do it now?


Current mass vaccination strategies require each individual to be inoculated with 1 or more doses of vaccine. For humans, this can be accomplished at PODs or doctors’ offices, by healthcare providers, but for wild animal populations there is the added challenge of animals being difficult to track and catch.

One relatively successful approach to vaccinating wild animal populations is through use of oral baits. For example, oral rabies vaccine baits have been dropped aerially into animal habitats to reach vulnerable species like foxes and bats. This approach relies on development of a suitable and stable vaccine and timely bait uptake, and it may not reach all vulnerable animals. Nevertheless, it has contributed significantly to rabies elimination in a number of geographic areas,41 and it is also being used for other diseases like Lyme disease.42

In human pandemics, each element in the pipeline of vaccine production, distribution, and administration would have significant difficulties in scaling effectively to address the crisis. For example, if vaccine cannot be produced at scale, or if the healthcare system cannot flex to accommodate the administration of millions of doses of vaccine, the effectiveness of the response will be diminished.

What does success look like?

If used in animals, successful implementation of self-spreading vaccines would prevent spillover of pathogens with pandemic potential into human populations without the need for difficult and costly mass vaccination operations in animal populations. For example, inoculation of relatively few bats and nonhuman primates against Ebola could potentially limit or eliminate human outbreaks. Sufficient coverage could even eradicate animal diseases, permanently eliminating these risks to both animals and humans.

For human use, targeted release of weakly transmissible self-spreading vaccine early in an outbreak could create herd immunity in communities and prevent an outbreak from becoming a pandemic. If introduced later, after an outbreak has become widespread, self-spreading vaccines could still help to protect suscep- tible individuals and limit the number of new cases and prevent catastrophic outcomes.

While self-spreading vaccines could help reduce illness and death in a severe pandemic, this approach comes with several big challenges. One important component of the current vaccination approach for humans is the informed consent process. In order to receive a vaccine, individuals (or their legal guardians) must be informed about the risks of vaccination by a healthcare provider and provide their consent before being vaccinated. Those who decline are not forced to receive a vaccine. In the case of self-spreading vaccines, the individuals directly vaccinated would have this option, but those

to whom the vaccine subsequently spreads would not. Additionally, self-spreading vaccines would potentially infect individuals with contraindications, such as allergies, that could be life-threatening. The ethical and regulatory challenges surrounding informed consent and prevention and monitoring of adverse events would be critical challenges to implementing this approach even in an extreme event.

Finally, there is a not insignificant risk of the vaccine virus reverting to wild-type virulence, as has sometimes occurred with the oral polio vaccine—which is not intended to be fully virulent or transmissible, but which has reverted to become both neurovirulent and transmissible in rare instances. This is both a medical risk and a public perception risk; the possibility of vaccine-induced

disease would be a major concern to the public. Modeling efforts suggest that making self-spreading vaccines weakly transmissible might reduce the risk of reversion to wild-type virulence by limiting the number of opportunities for the virus to evolve. However, weakly transmissible vaccines would have to be introduced to more people to obtain sufficient immunity in the target population.

high impact
In Humans
In Animals
loW impact


Key Readings:


Bull JJ, Smithson MW, Nuismer SL. Transmissible viral vaccines. Trends Microbiol 2018;26(1):6-15. https://doi.org/10.1016/j.tim.2017. 09.007. Accessed June 25, 2018.

Murphy AA, Redwood AJ, Jarvis MA. Self-disseminating vaccines for emerging infectious diseases. Expert Rev Vaccines 2016;15(1):31-39. https://doi.org/10.158 6/14760584.2016.1106942. Accessed June 25, 2018.

Nuismer SL, Althouse BM, May R, Bull JJ, Stromberg SP, Antia R. Eradicating infectious disease using weakly transmissible vaccines. Proc Biol Sci 2016;283(1841). https://doi.org/10.1098/rspb.2016.1903. Accessed June 25, 2018.

Torres JM, Sánchez C, Ramírez MA, et al. First field trial of a transmissible recombinant vaccine against myxomatosis and rabbit hemorrhagic disease. Vaccine 2001;19(31):4536-4543. Redirecting. Accessed June 25, 2018.

Tsuda Y, Caposio P, Parkins CJ, et al. A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus. PLoS Negl Trop Dis 2011;5(8):e1275.

A Replicating Cytomegalovirus-Based Vaccine Encoding a Single Ebola Virus Nucleoprotein CTL Epitope Confers Protection against Ebola Virus. Accessed June 25, 2018.
 
Last edited:

Faroe

Un-spun
There is also the nano lipids that carry these questionable compounds. Acc. to the doctor in the ten min video (Robert David Steele website), these lipids can get into the organs, inc. past the blood-brain barrier.

He did not address pheromones of menses, but basically validated everything else CH has recently said.
 

TammyinWI

Talk is cheap
Page 8 of Exec Summary: Self-Spreading Vaccines: Self-spreading vaccines are genetically engineered to move through populations like communicable diseases, but rather than causing disease, they confer protection. The vision is that a small number of individuals in a target population could be vaccinated, and the vaccine strain would then circulate in the population much like a pathogenic virus, resulting in rapid, widespread immunity.

Pages 45 - 47:

whAT is The TeChnoloGy?

Self-spreading vaccines—also known as transmissible or self-propagatingvaccines—are genetically engineered to move through populations in the same way as communicable diseases, but rather than causing disease, they confer
protection. The vision is that a small number of individuals in the target population could be vaccinated, and the
vaccine strain would then circulate in the population much like a pathogenic virus. These vaccines could dramatically increase vaccine coverage in human or animal populations without requiring each individual to be inoculated. This technology is currently aimed primarily at animal populations. Because most infectious diseases are zoonotic,40 controlling disease in animal populations would also reduce the risk to humans.

There are 2 main types of self-spreading vaccines: recombinant vector vaccines and live viral vaccines. Recombinant vector vaccines combine the elements of a pathogenic virus that induce immunity (removing the portion that causes disease) with a transmissible viral vector. Cyto- megalovirus is one candidate vector for recombinant vaccines, because
it is highly species-specific and moderately transmissible. Live viral vaccines are attenuated, meaning that the vaccine viruses are much less pathogenic than wild-type and would be similar to the oral polio vaccine or the live attenuated influenza vaccine (LAIV) in that those vaccines can sometimes transmit from person to person.

Although there are substantial technical challenges in genetically engineering viruses, synthetic biology tools such as CRISPR/Cas9 are likely to aid researchers in overcoming these hurdles in the coming years. Self-spreading vaccines have already been used to protect wild rabbits from myxomatosis and to control
Sin Nombre virus in rodent populations. Additional work is targeting Ebola virus in apes and bats, Lassa virus in rats, and bovine tuberculosis in badgers

whAT pRoBleM
Does This solve?


The most practical and useful application of self-spreading vaccines would be to control disease spread in wild animal populations (also known as sylvatic spread). A vaccine would be administered to a few selected animals in hotspots among target populations including nonhuman primates, bats, or rodents. The vaccine would then spread within the target
population, eliminating the need to vaccinate each animal. Successful disease control in animal populations could limit the number of infected animals and thereby reduce the opportunity for the disease to spill over into humans, thus stopping outbreaks in humans before they ever emerge. Such a sylvatic strategy would reduce the overall number of outbreak opportunities in humans, but it could not interrupt an outbreak once it becomes established in humans.

In the event of a grave public health threat, self-spreading vaccines could potentially be used to broadly inoculate human populations. Like the approach in animals, only a small number of vaccinated individuals would be required in order to confer protection to a larger susceptible population, thus eliminating the need for mass vaccination operations, including PODs.

self-spreading vaccines
45

medical
Countermeasure
distribution, dispensing,
and administration


46


how Do we Do iT now?


Current mass vaccination strategies require each individual to be inoculated with 1 or more doses of vaccine. For humans, this can be accomplished at PODs or doctors’ offices, by healthcare providers, but for wild animal populations there is the added challenge of animals being difficult to track and catch.

One relatively successful approach to vaccinating wild animal populations is through use of oral baits. For example, oral rabies vaccine baits have been dropped aerially into animal habitats to reach vulnerable species like foxes and bats. This approach relies on development of a suitable and stable vaccine and timely bait uptake, and it may not reach all vulnerable animals. Nevertheless, it has contributed significantly to rabies elimination in a number of geographic areas,41 and it is also being used for other diseases like Lyme disease.42

In human pandemics, each element in the pipeline of vaccine production, distribution, and administration would have significant difficulties in scaling effectively to address the crisis. For example, if vaccine cannot be produced at scale, or if the healthcare system cannot flex to accommodate the administration of millions of doses of vaccine, the effectiveness of the response will be diminished.

whAT Does suCCess
looK liKe?

If used in animals, successful implementation of self-spreading vaccines would prevent spillover of pathogens with pandemic potential into human populations without the need for difficult and costly mass vaccination operations in animal populations. For example, inoculation of relatively few bats and nonhuman primates against Ebola could potentially limit or eliminate human outbreaks. Sufficient coverage could even eradicate animal diseases, permanently eliminating these risks to both animals and humans.

For human use, targeted release of weakly transmissible self-spreading vaccine early in an outbreak could create herd immunity in communities and prevent an outbreak from becoming a pandemic. If introduced later, after an outbreak has become widespread, self-spreading vaccines could still help to protect suscep- tible individuals and limit the number of new cases and prevent catastrophic outcomes.

While self-spreading vaccines could help reduce illness and death in a severe pandemic, this approach comes with several big challenges. One important component of the current vaccination approach for humans is the informed consent process. In order to receive a vaccine, individuals (or their legal guardians) must be informed about the risks of vaccination by a healthcare provider and provide their consent before being vaccinated. Those who decline are not forced to receive a vaccine. In the case of self-spreading vaccines, the individuals directly vaccinated would have this option, but those

to whom the vaccine subsequently spreads would not. Additionally, self-spreading vaccines would potentially infect individuals with contraindications, such as allergies, that could be life-threatening. The ethical and regulatory challenges surrounding informed consent and prevention and monitoring of adverse events would be critical challenges to implementing this approach even in an extreme event.

Finally, there is a not insignificant risk of the vaccine virus reverting to wild-type virulence, as has sometimes occurred with the oral polio vaccine—which is not intended to be fully virulent or transmissible, but which has reverted to become both neurovirulent and transmissible in rare instances. This is both a medical risk and a public perception risk; the possibility of vaccine-induced

disease would be a major concern to the public. Modeling efforts suggest that making self-spreading vaccines weakly transmissible might reduce the risk of reversion to wild-type virulence by limiting the number of opportunities for the virus to evolve. However, weakly transmissible vaccines would have to be introduced to more people to obtain sufficient immunity in the target population.

high impact
In Humans
In Animals
loW impact


Key ReADinGs


Bull JJ, Smithson MW, Nuismer SL. Transmissible viral vaccines. Trends Microbiol 2018;26(1):6-15. https://doi.org/10.1016/j.tim.2017. 09.007. Accessed June 25, 2018.

Murphy AA, Redwood AJ, Jarvis MA. Self-disseminating vaccines for emerging infectious diseases. Expert Rev Vaccines 2016;15(1):31-39. https://doi.org/10.158 6/14760584.2016.1106942. Accessed June 25, 2018.

Nuismer SL, Althouse BM, May R, Bull JJ, Stromberg SP, Antia R. Eradicating infectious disease using weakly transmissible vaccines. Proc Biol Sci 2016;283(1841). https://doi.org/10.1098/rspb.2016.1903. Accessed June 25, 2018.

Torres JM, Sánchez C, Ramírez MA, et al. First field trial of a transmissible recombinant vaccine against myxomatosis and rabbit hemorrhagic disease. Vaccine 2001;19(31):4536-4543. Redirecting. Accessed June 25, 2018.

Tsuda Y, Caposio P, Parkins CJ, et al. A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus. PLoS Negl Trop Dis 2011;5(8):e1275.

A Replicating Cytomegalovirus-Based Vaccine Encoding a Single Ebola Virus Nucleoprotein CTL Epitope Confers Protection against Ebola Virus. Accessed June 25, 2018.

Thank you very much!
 
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