CRISIS CDC expected to release report predicting as many as 1.4 million cases of Ebola by January

Dennis Olson

Chief Curmudgeon
_______________
CDC expected to release report predicting as many as 1.4 million cases of Ebola by January
Published September 23, 2014
FoxNews.com


The U.S. Centers for Disease Control and Prevention (CDC) is expected to release a report Tuesday predicting as many as 550,000 to 1.4 million cases of the Ebola virus in Liberia and Sierra Leone alone, by the end of January.

The CDC calculations are based, in part, on assumptions that cases have been dramatically underreported. Other projections haven't made the same kind of attempt to quantify illnesses that may have been missed in official counts.

CDC scientists conclude there may be as many as 21,000 reported and unreported cases in just those two countries as soon as the end of this month, according to a draft version of the report obtained by The Associated Press.

The agency's numbers seem "somewhat pessimistic" and do not account for infection control efforts already underway, said Dr. Richard Wenzel, a Virginia Commonwealth University scientist who formerly led the International Society for Infectious Diseases.

Separately, the World Health Organization (WHO) warned in a new report that the number of people infected with the Ebola virus could reach 20,000 by the beginning of November if efforts to contain the outbreak are not accelerated.

The outbreak has killed around 2,800 people in five West African countries this year. An estimated 5,800 people have been infected with the virus, which has no known cure. The WHO has repeatedly said that the actual number of infections and deaths is almost certainly higher than the official figures.

The report, published six months after the first cases were reported, is far more pessimistic than an earlier survey published last month, in which the WHO suggested that the number of cases could reach 20,000 by the middle of next year. According to The New York Times, the report also raises the possibility that the outbreak will cause Ebola to become endemic in West Africa.

The WHO said Monday that the Ebola outbreak was "pretty much contained" in Nigeria and Senegal. However, the death rate among infected is currently at around 70 percent in the other three countries touched by the infection: Liberia, Sierra Leone, and Guinea. Of those three, Liberia has reported the most Ebola cases, at just over 3,000.

The epidemic has overwhelmed the healthcare systems of all three countries, which rank among the world's poorest. There aren't enough hospital beds, health workers or even soap and water.

Last week, the U.S. announced it would build more than a dozen medical centers in Liberia and send 3,000 troops to help. Britain and France have also pledged to build treatment centers in Sierra Leone and Guinea and the World Bank and UNICEF have sent more than $1 million worth of supplies to the region.

"We're beginning to see some signs in the response that gives us hope this increase in cases won't happen," Christopher Dye, WHO's director of strategy and study co-author, told the Associated Press. "This is a bit like weather forecasting. We can do it a few days in advance, but looking a few weeks or months ahead is very difficult."

Other outside experts questioned the WHO's projections and said Ebola's spread would ultimately be slowed not only by containment measures but by changes in people's behavior.

"It's a big assumption that nothing will change in the current outbreak response," said Dr. Armand Sprecher, an infectious diseases specialist at Doctors Without Borders.

"Ebola outbreaks usually end when people stop touching the sick," he said. "The outbreak is not going to end tomorrow but there are things we can do to reduce the case count."

Local health officials have launched campaigns to educate people about the symptoms of Ebola and not to touch the sick or the dead. Previous Ebola outbreaks have been in other areas of Africa; this is the first to hit West Africa.

The Associated Press contributed to this report.

Click for more from The New York Times.

http://www.foxnews.com/health/2014/09/23/who-forecasts-more-than-20000-ebola-cases-by-november-2/
 

Publius

TB Fanatic
Expect it to be two million by January and they are playing games with everyone and know better.
At this point our government has shown their hand and don't care if we know they want to destroy the world's population. They also have the antidote and not going to share with just anyone.
 

Millwright

Knuckle Dragger
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Somebody posted an article that said number of ebola cases were doubling every 3 weeks.

Once this goes exponential, ISIS will be the least of our concerns.
 

dstraito

TB Fanatic
Somebody posted an article that said number of ebola cases were doubling every 3 weeks.

Once this goes exponential, ISIS will be the least of our concerns.

Exactly.

Anyone remember the commercial about a person telling two friends and those two telling two friends and all of a sudden there is a screen full of images so small they make up a picture.

Another way to look at it. Would you rather have a million dollars or would you start with a penny and double the sum every day for 30 days?

Most people take a million dollars. Those people do not understand exponential.

2 to the 30th power is $10,737,418.24

so if you basically took one person and doubled it every 3 weeks and multiplied that by 30 then in 90 weeks we would have 10 million infected but the chances are the 3 week time period for doubling would be reduced greatly.
 

summerthyme

Administrator
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Well, as Kris keeps pointing out, it HAS gone exponential. That's what "exponential" means... it's following his numbers from his earliest spreadsheets so exactly it's terrifying.

Summerthyme
 

jaw1969

Senior Member
Exactly.

Anyone remember the commercial about a person telling two friends and those two telling two friends and all of a sudden there is a screen full of images so small they make up a picture.

Another way to look at it. Would you rather have a million dollars or would you start with a penny and double the sum every day for 30 days?

Most people take a million dollars. Those people do not understand exponential.

2 to the 30th power is $10,737,418.24

so if you basically took one person and doubled it every 3 weeks and multiplied that by 30 then in 90 weeks we would have 10 million infected but the chances are the 3 week time period for doubling would be reduced greatly.

IN 93 week it will have infected everyone on the plant
 

Hfcomms

EN66iq
Well, as Kris keeps pointing out, it HAS gone exponential. That's what "exponential" means... it's following his numbers from his earliest spreadsheets so exactly it's terrifying.

Summerthyme


An ebola 'panic' will hit the U.S. at some point late fall to winter. Some of it will be of legitimate threat and other parts will be hype but for now most people think of it as something 'over there' if they think of it at all. People need to be prepared to shelter in place for an extended period of time with no outside support at all. Hopefully it won't get that bad here....but it might. Hopefully most of us are indeed preppers and walk the walk and not just talk the talk. The window to get supplies ahead of time will rapidly close. Things such as gloves, masks, Tyvek suiting and basic medical gear will disappear in a matter of hours or be priced beyond what most can afford. Right now they are cheap. When people panic they will buy all that they can even though they have no idea what they are buying the stuff for. Get it when you can and while you can.
 

Kris Gandillon

The Other Curmudgeon
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The simple math, which has been correct for 7 months now, (since March when official counts started coming out), says we have 14 months to go (November 2015) before all 7.2 Billion of us would have at least had the chance to be exposed to Ebola if not infected with Ebola.

Of course, that is simply extending the formula for the last 7 months into the future for the next 14 months until we reach the number 7.2 Billion which is the approximate population of the Earth.

Some other numbers that could easily occur is that this outbreak remains 99.9% confined to the African continent until all 1.1 Billion of the African population are exposed or infected which at current rates would take us through September of 2015.

99.9% confined to Africa sounds like a great number until you realize that .1 percent (yes 1/10th of a percent) represents over 1 million exposed/infected people outside of Africa that would serve as new vectors for this thing to escape Africa in a big way.

This 2014 Ebola Outbreak is over 3 times as large as all previous Ebola outbreaks over the last 38 years added together, and has lasted over twice as long as the average previous Ebola outbreak.

It shows no signs of slowing down or stopping yet.

The ONLY WAY previous outbreaks were stopped is because they were in small remote villages (a few hundred people at most) where the outbreak could be contained and controlled as it burned through most of the entire village. This one is taking hold in highly populated cities like Monrovia, Liberia, home to 1 million people.

We are in totally uncharted waters regarding this disease which is a Level 4 Pathogen that kills between 2 and 3 out of every 4 people that get infected and get treatment and it typically kills 9 out of 10 if they are untreated.
 

Meadowlark

Has No Life - Lives on TB
Did anyone see the ebola special last night. A lot of the problem is behavioral. People competely ignorant of proper hygene during an outbreak, breaking quarrentine, refusing to report illness hoping it will go away, refusal to report the dead and clandestine burial. All the stuff of nightmares, not to mention a virtual lack of law and order.
 

Adino

paradigm shaper
could we be getting to these numbers if there was only infection via contact w/ fluid or do we pretty much have to be looking at airborne transmission for the rate of infection to have gone parabolic the way they have?
 

Dennis Olson

Chief Curmudgeon
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The MSM will be given orders not to report Ebola AS Ebola. It will be reported as a massive "flu" outbreak.
 

Dennis Olson

Chief Curmudgeon
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US, Canada allow emergency use of Tekmira's Ebola treatment

RELATED:


US, Canada allow emergency use of Tekmira's Ebola treatment
Published September 23, 2014
Reuters


Canadian drugmaker Tekmira Pharmaceuticals Corp said on Monday that U.S. and Canadian regulators have authorized the use of its Ebola treatment in patients who have confirmed or suspected infections from the deadly virus.

The Vancouver-based company said its treatment, TKM-Ebola, has been administered to patients on an emergency basis and the repeat infusions have been well-tolerated.

The drug was administered to Rick Sacra, a doctor who contracted the virus in West Africa, and who has shown promising signs, the Nebraska Medical Center said in a statement.

TKM-Ebola, an RNAi therapeutic, works by preventing the virus from replicating.

Expanded access protocols, authorized by the U.S. Food and Drug Administration and Health Canada, allow drug developers to offer experimental therapies to patients with serious diseases who cannot participate in controlled clinical trials.

Tekmira Chief Executive Officer Mark Murray said the company's supplies of the treatment are limited.

The company is developing TKM-Ebola under a contract with the U.S. Department of Defense.

Tekmira's shares closed 15 percent up at C$26.01 in Toronto and up 17 percent at $23.61 on the Nasdaq.

http://www.foxnews.com/health/2014/09/23/us-canada-allow-emergency-use-tekmira-ebola-treatment/
 

Dennis Olson

Chief Curmudgeon
_______________
Ebola drug trials to be fast-tracked in West Africa

RELATED:


Ebola drug trials to be fast-tracked in West Africa
Published September 23, 2014
Reuters


Several experimental Ebola drugs, including compounds from Mapp Biopharmaceutical, Sarepta and Tekmira, will be tested in West Africa for the first time in a bid to fast-track trials, the Wellcome Trust charity said on Tuesday.

Announcing a 3.2 million pounds ($5.25 million) grant for the work, the global health charity said the money would "enable multiple partners around the world to quickly establish clinical trials at existing Ebola treatment centers".

An Ebola epidemic in West Africa has killed more than 2,800 people since it began in Guinea earlier this year, and the World Health Organization (WHO) has said it fears up to 20,000 people could be affected before it is brought under control.

The unprecedented outbreak of the virus, one of the most virulent infectious diseases known in humans, has been declared a threat to international peace and security by the UN Security Council and prompted demands for an urgent response.

In August a WHO expert panel unanimously concluded that in such exceptional circumstances it would be ethical to deploy and test unregistered experimental treatments on people with Ebola.

"It is a huge challenge to carry out clinical trials under such difficult conditions, but ultimately this is the only way we will ever find out whether any new Ebola treatments actually work," said Jeremy Farrar, the Wellcome Trust's director.

"What's more, rapid trials, followed by large-scale manufacturing and distribution of any effective treatments, might produce medicines that could be used in this epidemic."

The Wellcome Trust said several potential drugs are under consideration and a group of independent experts appointed by WHO is working to recommend which to prioritize based on factors such as which is likely to work best, their availability, the ability to give them safely, and whether they can be manufactured to a useful scale.

It said various pharma companies including Mapp, Sarepta, and Tekmira were working with the initiative and providing data on efficacy, safety, and production abilities for a number of the experimental treatments.


http://www.foxnews.com/health/2014/09/23/ebola-drug-trials-to-be-fast-tracked-in-west-africa/
 

Kris Gandillon

The Other Curmudgeon
_______________
RELATED:


Ebola drug trials to be fast-tracked in West Africa
Published September 23, 2014
Reuters


Several experimental Ebola drugs, including compounds from Mapp Biopharmaceutical, Sarepta and Tekmira, will be tested in West Africa for the first time in a bid to fast-track trials, the Wellcome Trust charity said on Tuesday.

Announcing a 3.2 million pounds ($5.25 million) grant for the work, the global health charity said the money would "enable multiple partners around the world to quickly establish clinical trials at existing Ebola treatment centers".

An Ebola epidemic in West Africa has killed more than 2,800 people since it began in Guinea earlier this year, and the World Health Organization (WHO) has said it fears up to 20,000 people could be affected before it is brought under control.

The unprecedented outbreak of the virus, one of the most virulent infectious diseases known in humans, has been declared a threat to international peace and security by the UN Security Council and prompted demands for an urgent response.

In August a WHO expert panel unanimously concluded that in such exceptional circumstances it would be ethical to deploy and test unregistered experimental treatments on people with Ebola.

"It is a huge challenge to carry out clinical trials under such difficult conditions, but ultimately this is the only way we will ever find out whether any new Ebola treatments actually work," said Jeremy Farrar, the Wellcome Trust's director.

"What's more, rapid trials, followed by large-scale manufacturing and distribution of any effective treatments, might produce medicines that could be used in this epidemic."

The Wellcome Trust said several potential drugs are under consideration and a group of independent experts appointed by WHO is working to recommend which to prioritize based on factors such as which is likely to work best, their availability, the ability to give them safely, and whether they can be manufactured to a useful scale.

It said various pharma companies including Mapp, Sarepta, and Tekmira were working with the initiative and providing data on efficacy, safety, and production abilities for a number of the experimental treatments.


http://www.foxnews.com/health/2014/09/23/ebola-drug-trials-to-be-fast-tracked-in-west-africa/

Here is one of the challenges, at least for QUICK mass production of ZMAPP:

ZMapp is manufactured in the tobacco plant Nicotiana benthamiana in the bioproduction process known as "pharming" by Kentucky BioProcessing, a subsidiary of Reynolds American.

Monoclonal antibodies (mAbs) were first created in mice by injecting them with antigens from Ebola, harvesting their spleens, and fusing mature B-cells producing monoclonal antibodies (mAbs) with cancer cell lines to create hybridomas.

After the best antibody was selected, the gene encoding the antibody was extracted, and certain portions were replaced with portions encoding human proteins, in the process called humanization.

To create a system to produce the humanized mAbs at commercial scale, Mapp used a process called "Rapid Antibody Manufacturing Platform" (RAMP), using magnICON (ICON Genetics) viral vectors.

In a process called "magnifection, "tobacco plants are infected with the viruses, using Agrobacterium cultures. Subsequently, antibodies are extracted and purified from the plants.

Once the genes encoding the humanized mAbs are in hand, the entire tobacco production cycle is believed to take a few months.

And here is a link to an article that discusses this in a bit more detail: http://www.journalnow.com/news/loca...cle_144fb3ce-1cb3-11e4-9f1b-0017a43b2370.html
 

Adino

paradigm shaper
The MSM will be given orders not to report Ebola AS Ebola. It will be reported as a massive "flu" outbreak.

i was going to say, and should've, i thought i read it was airborne but i also keep hearing just fluid contact

not like talking out of both sides of the mouth isn't the norm, but, ya know

i think 6 months from now the world will regret not shutting down non essential intercontinental travel
 

summerthyme

Administrator
_______________
Did anyone see the ebola special last night. A lot of the problem is behavioral. People competely ignorant of proper hygene during an outbreak, breaking quarrentine, refusing to report illness hoping it will go away, refusal to report the dead and clandestine burial. All the stuff of nightmares, not to mention a virtual lack of law and order.

And does anyone REALLY believe it will be any different if it gets to America? If so, you're dreaming. I've seen middle aged wealthy women beating the hell out of each other for "deals" at Filene's basement sales... think about what it will be like when the food shortages start! And given the current distrust of all levels of government (with a lot of justification, I admit) if the CDC told everyone to shelter in place, a significant number would do the opposite... "just because". Not to mention the group the riots at the drop of a hat, and who would take the "opportunity" of empty streets to get their new Nikes and big screen Teevees, with a side of Ebola.

Talk about a nightmare!

Summerthyme
 

Kris Gandillon

The Other Curmudgeon
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I posted a few weeks back that the CDC was admitting airborne transmission.

I have only seen mentioned the "aerosol" version of "airborne" which is still droplet oriented.

TRUE "airborne" is "virus-only" floating along on the breezes great distances like chickenpox, measles and TB can do. I have NOT personally seen that mentioned in regards to Ebola...YET.
 

Dennis Olson

Chief Curmudgeon
_______________
I didn't know there was a difference. If something is an aerosol, it's floating in the air. But I guess I see the diffence.


It depends on what the definition of "is" is... ;)
 

TheSearcher

Are you sure about that?
I didn't know there was a difference. If something is an aerosol, it's floating in the air. But I guess I see the diffence.


It depends on what the definition of "is" is... ;)

Here's an analog to think about:

To survive space travel, you have to be surrounded by an atmosphere sufficiently rich in oxygen and moderate enough in temperature and pressure to breathe and not bleed away our bodily fluids into space. Usually, that requires a spacecraft or a space station. We at least need a spacesuit, and it only protects you for a relatively short time. Superman can fly about in the void indefinitely without a space suit and still do whatever it is that superpeople need to do.

Truly airborne Ebola is Superman Ebola, and we apparently have yet to find kryptonite...
 

Dex

Constitutional Patriot
The numbers seems to be a little bit on the conservative. The exponential qualities of the data and the potential for its spread into Europe and the west will raise the stakes possibly in a matter of days rather than weeks. All it will take is a few of the infected to make it out of quarantine and shed enough of the virus through the mass transportation systems to turn this into a global pandemic in a matter of few days rather than weeks.

I'm not sure we've ever seen the world in more danger than what we are seeing now wit this West African outbreak that is quite obviously out of control and almost guaranteed to break out into western continents in the very near future. You can't control people who are too ignorant and stubborn to understand the ramifications of non-compliance of quarantine.
 

Frugal Bob

Veteran Member
No I think it can and will kill 70 to 90% of the world population before December 2015 if we as a world don't make some very difficult decision in the next week or two...

Georgia guide stones 2014 the beginning of the grate culling maintain humanity under 500,000,000 in perpetual balance with nature.
 

Coulter

Veteran Member
No I think it can and will kill 70 to 90% of the world population before December 2015 if we as a world don't make some very difficult decision in the next week or two...

I thought I read somewhere that the survival rate was 55%.

But in hindsight I wonder if that is a rate for - all - or say a population under 35.



I remember Savage saying that semen is contagious for up to 13 weeks AFTER the infected has recovered.
 

HangingDog

Veteran Member
No I think it can and will kill 70 to 90% of the world population before December 2015 if we as a world don't make some very difficult decision in the next week or two...

I find it naïve to think that ebola will travel as fast through low density populations as it travels through high density populations. At some point the rate of infection will slow then flatten then fall.
The 1918 Swine flu had a very high ROI and ultimately infected 1/3 of the population. Doctors/scholars say that the 1918 flu killed up to 5% of the people that it infected. Granted a far cry from ebola numbers. I wonder which disease is more infectious. Wife's grandmother lived in philly during the period. She said at the worst of it you were to put dead bodies out at the street and a wagon would come by twice a day.
 

jaw1969

Senior Member
They (WHO) has revised the mortality rate up to 70% or so with care without care it is higher historically up to 90%
I thought I read somewhere that the survival rate was 55%.

But in hindsight I wonder if that is a rate for - all - or say a population under 35.



I remember Savage saying that semen is contagious for up to 13 weeks AFTER the infected has recovered.
 

jaw1969

Senior Member
I find it naïve to think that ebola will travel as fast through low density populations as it travels through high density populations. At some point the rate of infection will slow then flatten then fall.
The 1918 Swine flu had a very high ROI and ultimately infected 1/3 of the population. Doctors/scholars say that the 1918 flu killed up to 5% of the people that it infected. Granted a far cry from ebola numbers. I wonder which disease is more infectious. Wife's grandmother lived in philly during the period. She said at the worst of it you were to put dead bodies out at the street and a wagon would come by twice a day.

Different opinions are what makes the world go around
With a 70% Mortality rate Me and mine are making preparations for a extended stay at home . With the statements from the CDC of 1.4 million infected possible by January It is only prudent to. Ebola is a whole different monster than the Flu pandemic with a paltry 5% mortality rate and they where taking the dead out twice a day Just think what 70 % DEAD will do to our modern way of life .. I also find it personally insulting to call my position naïve .
 

Kris Gandillon

The Other Curmudgeon
_______________
I thought I read somewhere that the survival rate was 55%.

But in hindsight I wonder if that is a rate for - all - or say a population under 35.



I remember Savage saying that semen is contagious for up to 13 weeks AFTER the infected has recovered.

About a week ago, we all discovered that we (including the WHO) were calculating the PFC and not the CFR though WHO was calling it the CFR in their reports.

In reality, the true CFR cannot be accurately calculated until the end of the outbreak, once no one else is getting infected and no one else is dying of the disease.

In this outbreak it seems that the "mean" date of death is 16 days after infection/symptoms appear. Therefore, as large as this outbreak has become there are literally hundreds of deaths that will occur during the 2-3 weeks after the last person is infected. THAT modification to the calculation adds about 15-20% to the final CFR as it stands today.

So our PFC is what is in the 53-57% range currently but the 16 day lagged CFR is around 70-71% currently. And that is TRACKED counts only. It is likely in the 85-90% range if all infected and dead could be counted accurately instead of based on anecdotal reports from the affected areas.
 

Dennis Olson

Chief Curmudgeon
_______________
Kris, you gotta stop fat-fingering the CLOSE THREAD checkbox when you post. I can tell you caught RB's "little problem"...

:p
 

Dennis Olson

Chief Curmudgeon
_______________
Georgia guide stones 2014 the beginning of the grate culling maintain humanity under 500,000,000 in perpetual balance with nature.


Translation:

The elites keep their McMansions and Escalades, and the rest of the survivors live caves and eat dirt.



But those elites had better hope that nothing breaks down, because no one will be left to fix anything or build new stuff.


Eloi...
 
Translation:

The elites keep their McMansions and Escalades, and the rest of the survivors live caves and eat dirt.



But those elites had better hope that nothing breaks down, because no one will be left to fix anything or build new stuff.


Eloi...

Yeah, they just want enough us around for servitude, exploitation, cosmopolitan entertainment, and for feeling superior. It's lonely at the top, especially if you are a bottom feeder, as most of them are these days around the world.
 
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