CORONA Main Coronavirus thread

bev

Has No Life - Lives on TB
I just watched a truly terrifying video. It’s called “A Waking Nightmare for Covid19 Patients” and interviews patients who were sedated and on ventilators with Covid19. They describe what they saw and felt during that time, and doctors explain that they’re seeing it - actually hearing about it - after the patients go home. Some develop PTSD. There will be a big need for mental health support after these patients go home.

Just under 10 minutes

View: https://www.youtube.com/watch?v=8_AKe07J7tE
 

Heliobas Disciple

TB Fanatic
(fair use applies)

'Reopening' won't fix the economy. Beating the virus will.
David Plotz and Henry Blodget
12 hours ago

'Reopening' won't fix our economy. What will fix it are declining cases and deaths.
As the political fight about "health versus the economy" continues, it's worth repeating: It's not one or the other. It's both.
Reopening is an important and meaningful step. But even when everything is open, our economy won't recover until people feel safe resuming their normal lives.

"Most of the slowdown occurred due to voluntary social distancing rather than lockdowns," Bank of America Merrill Lynch economists concluded this week.

Charts from the excellent economics site Calculated Risk confirm this.

Take the number of TSA airport safety checks this year (red) versus last year (blue). There have never been formal restrictions on air travel in the US. But flying is perceived as risky. And even now air travel is only about 10% of normal levels.

Screen Shot 2020 05 21 at 9.11.30 AM

Calculated Risk

Similarly, restaurants in many states are now open again. Some diners are returning, especially in states that began opening a few weeks ago. But we're still only a tiny fraction of normal.


Screen Shot 2020 05 21 at 9.09.49 AM

Calculated Risk

Other charts at Calculated Risk show the same trends. Hotel occupancy is still way below normal, for example. Movie-theater attendance is flatlined at zero.

If reopening won't fix our economy, what will? People seeing that the risk to themselves and their families and friends is low.

As we relax restrictions, we must continue to do everything we reasonably can to reduce the spread of the virus — namely, distancing, mask wearing, handwashing, and increasing our testing, tracing, and isolation capabilities. —HB

Sweden's looser restrictions have not saved its economy

Those who blame lockdowns for the state of the economy often point to Sweden as a country that has taken a smarter and more balanced approach.

Sweden does have restrictions — large gatherings are banned and distancing is encouraged — but schools and businesses are open.

The price Sweden has paid for this looser approach is well known: a lot more death.

Economists at Morgan Stanley charted the death rate per million in Sweden (yellow) as compared to Denmark (black), a country that took a more restrictive approach:

Screen Shot 2020 05 21 at 9.42.40 AM

Morgan Stanley

Sweden's sacrifice is sometimes framed as a more reasonable balance between health and the economy. After all, life is risky, Sweden's boosters say, and most of the people who've died were older people who would have died soon.
But here's the part that Sweden advocates often miss.

Sweden's economy has still been demolished.

A new paper concludes that, despite the looser restrictions, consumer spending in Sweden has dropped 25% from normal levels. Spending in Denmark has dropped just 4 points more — 29%. The looser restrictions haven't made much difference.

As Sweden's death rate continues to climb — and as the country remains miles from the nirvana of "herd immunity" — experts in Sweden are increasingly speaking out about their frustration with the country's approach. One of these experts told Insider's Sinead Baker that Sweden's approach is "not something anyone should copy."

Morgan Stanley draws the same conclusion from the Sweden and Denmark data that we and others have been articulating for weeks:

"The economic downturn has been primarily because of the virus. Ending lockdowns is not a panacea." —HB

Meanwhile in Japan

Those advocating for looser restrictions should focus instead on Japan. Despite looser lockdowns than elsewhere — and despite having large numbers of older people — Japan's death and infection rates are low.

Why? Perhaps because of the country's commitment to hygiene and mask wearing.

In Japan, and elsewhere, people are increasingly resuming their normal lives. They're just doing it in masks. —HB
 

Heliobas Disciple

TB Fanatic
More on this new study:

(fair use applies)

How coronavirus hijacks human cells and takes over our genes then turns our immune system against us: 'It's like nothing I've seen in 20 years' says virologist
By Mary Kekatos
Published: 15:34 EDT, 21 May 2020 | Updated: 22:26 EDT, 21 May 2020

  • Typically, the body's cells have two groups of virus-fighting genes: interferons and chemokines
  • Interferons are 'call-to-arms' genes that interfere with the virus's ability to multiply itself
  • Chemokines are 'call-for-reinforcements' genes that call for immune cells to go the site of an infection so they can target and destroy the virus
  • Coronavirus blocks interferons, allowing the virus to replicate, but chemokines still get the call to go to the site of infection
  • This overproduction of immune cells leads to over-inflammation and causes dangerous cytokine storms, in which the body attacks its own tissues
  • Researchers say this could lead to treatment that focuses on restoring the pathway being blocked by coronavirus
The novel coronavirus 'hijacks' our body's cells by blocking certain genes that fight against infections, a new study suggests.

Viruses, such as the flu, usually interfere with two sets of genes: one that prevents viruses from replicating and the other that sends immune cells to the infection site to kill viruses.

But researchers found SARS-CoV-2 behaves differently, inhibiting the genes that stop the virus from copying itself but allowing the genes that call for immune cells to behave normally.

This causes the virus to multiply and an overproduction of immune cells to flood the lungs and other organs, which leads to unmitigated inflammation.

The team, from the Icahn School of Medicine at Mount Sinai in New York City, says treatment for patients in the early throes of the disease should be focused on restoring the pathway being blocked by coronavirus rather than focusing on inflammation.

Dr Benjamin tenOever, a virologist and professor of microbiology at the Icahn School of Medicine, told DailyMail.com that an infected cell has 'two jobs to do'.

'One job is to tell all the cells around you to fortify...and the second job is to recruit the more professional immune cells to that site of infection,' he said.

Typically, our body's cells have two groups of virus-fighting genes: interferons and chemokines.

Interferons are signaling proteins released by infected cells and are named for their prowess to 'interfere' with the virus's ability to multiply itself.

Chemokines are small molecules that call for immune cells to go the site of an infection so they can target and destroy the virus.

According to tenOever, the first set of genes control virus replication for about seven to 10 days so the second set has enough time to get immune cells to attack.

He refers to interferons as the 'call-to-arms' genes and to chemokines as the 'call-for-reinforcement' genes.

'The vast majority of viruses that you encounter in nature are readily neutralized and destroyed by these systems,' tenOever said.

'Even the very first defense, the "call-to-arms," is often enough to completely stop replication and neutralize the infection without even generating the second response.'

But, unlike the flu or Severe Acute Respiratory Syndrome (SARS), the coronavirus blocks one set of genes and activates the other.

For the study, published in the journal Cell, the team looked at healthy human lung cells and an animal model in ferrets.

They found a very mild response from the 'call-to-arms' genes - which block the virus's replication - and a large introduction of the 'call-for-reinforcement' genes.

'A combination of these two is a bad combination,' said tenOever.

When they looked at lung cells from two COVID-19 patients that died, they found the exact same response.

'Basically people are contracting the disease, SARS-CoV-2 enters the lungs and it begins to replicate and, at that site of replication, those cells that are infected, they don't do a good job of spreading the word about their infection which allows it to essentially fester in the lungs,' tenOever said.

This means the virus is replicating because there are not a lot of interferons, but those cells still call in for reinforcements.

So different types of immune system cells - neutrophils, macrophages and lymphocytes - arrive to fix the job, but, by the time they arrive, there has been nothing to control that virus.

'That virus has continued to replicate and continue to spread, getting to higher and higher numbers in the lungs, but they're calling for reinforcements,' tenOever said.

Now, the lungs have immune cells such as macrophages and neutrophils, which leads to inflammation that induces more inflammation. Essentially the immune system is turning against itself.

This is likely what leads to cytokine storms, which occur when the body attacks its own cells and tissues instead of just fighting off the virus.

TenOever says the way this virus behaves is 'nothing like I've seen in 20 years' of studying how cells respond to viral infections.

TenOever says there are two ways to treat patients.

The first group is made up of people who are just developing symptoms and have tested positive.

They can get drugs that induce the missing 'call-to-arms' genes so the virus can behave more like a flu.

'They can try treatments that restore the pathway that is being blocked by the virus, he said.

For those that are hospitalized and intubated it's already too late for this treatment so they would be more benefited by classes of drugs called interleukin-6 and interleukin-1 inhibitors.

These could help mitigate cytokine storms and reduce inflammation throughout the body.
 

Heliobas Disciple

TB Fanatic
(fair use applies)

'Am I going to have it forever?': Cambridge, Ont. woman tests positive for COVID-19 eight times in 50 days
Stephanie Villella, Jennifer K. Baker
Published Tuesday, May 19, 2020 5:33PM EDT Last Updated Tuesday, May 19, 2020 9:20PM EDT

KITCHENER -- After testing positive for COVID-19 seven times, a Cambridge, Ont., woman was relieved to hear that her eighth test came back negative.

“I cried because I was so happy,” says Tracy Schofield.

But that feeling didn’t last long.

In order to be considered recovered from the virus, patients must receive two negative results within a 24-hour period.

Schofield was swabbed for a ninth time, and once again she tested positive for COVID-19.

She started experiencing symptoms back on March 30, with a fever, chills, a headache and difficulty breathing. The next day she got her first COVID-19 tests, which eventually came back positive.

Schofield spent two weeks self-isolating at home, with only her 17-year-old son there to help. She says her temperature rose to 40.1 C, she could barely get out of bed and she even lost her sense of smell and taste.

While most of her symptoms have improved, some are still an issue.

“I still to this day have shortness of breath,” she says. “COVID-19 has taken a lot out of me, and it continues every day.”

It’s now been 50 days since Schofield first tested positive for the virus.

Eight of those tests have been positive, and only one negative.

Schofield says she has no underlying health concerns and worries that COVID-19 could cause long-term problems.

“I just want someone to be able to tell me something,” she says. “Give me an answer. Am I going to have it forever?”

Brian Dixon, an immunology professor at the University of Waterloo, says it’s not unusual to get a false negative on tests.

“You’re only giving a small sample from your body,” he explains. “So it may have been that they just missed it on that case. That’s why they do it twice. They want to be sure that they caught the right sample and you are negative.”

Dixon says everyone reacts differently to the virus, adding that some may be infected longer than others.

“It’s hard to say what’s normal,” he says. “We all have a particular immune system that’s individual.”

Since Schofield first shared her story with CTV News last week, she’s been contacted by others who are in the same situation.

“It’s comforting to know that they’re out there and they’ve contacted me,” she says. “I’m hoping just telling my story is helping them too, because they know they’re not alone either.”

Schofield now has to wait five more days until she can get tested again, for the 10th time.
 

Heliobas Disciple

TB Fanatic
This looks really promising. I hope it's true, it will change how things go forward if it is. But if it's a premature conclusion, it can make matters worse. I don't understand the rush to draw conclusions, it seems like every month the 'definitive' study from the month before is overturned. Now they dire ones are being replaced with the promising ones. I like the promising ones - but worry what next month's studies will conclude.



(fair use applies)

COVID patients testing positive after recovery aren’t infectious, South Korean study shows
By HEESU LEE AND JASON GALE | Bloomberg | Published: May 19, 2020

Researchers are finding evidence that patients who test positive for the coronavirus after recovering aren’t capable of transmitting the infection and could have the antibodies that prevent them from falling sick again.

Scientists from the Korean Centers for Disease Control and Prevention studied 285 COVID-19 survivors who had tested positive for the coronavirus after their illness apparently had resolved, as indicated by a previous negative test result. The so-called re-positive patients weren’t found to have spread any lingering infection, and virus samples collected from them couldn’t be grown in culture, indicating the patients were shedding noninfectious or inactive virus particles.

The findings, reported late Monday, are a positive sign for regions looking to open up as more patients recover from the pandemic that has sickened at least 4.8 million people. The emerging evidence from South Korea suggests those who have recovered from COVID-19 present no risk of spreading the coronavirus when physical-distancing measures are relaxed.

The results mean health authorities in South Korea no longer will consider people infectious after recovering from the illness. Research last month showed that so-called PCR tests for the coronavirus’s nucleic acid can’t distinguish between inactive and viable virus particles, potentially giving the wrong impression that someone who tests positive for the virus remains infectious.

The research also might aid in the debate over antibody tests, which look for markers in the blood that indicate exposure to the novel coronavirus. Experts believe antibodies probably convey some level of protection against the virus, but they don’t have any solid proof yet. Nor do they know how long any immunity might last.

A recent study in Singapore showed that patients who have recovered from severe acute respiratory syndrome, or SARS, are found to have “significant levels of neutralizing antibodies” nine to 17 years after initial infection, according to researchers including Danielle Anderson of Duke-NUS Medical School.

Other scientists have found higher levels of IgM, an antibody that appears in response to exposure to an antigen, in children, according to an article published on medRxiv. That suggests younger populations have the potential to produce a more potent defense against COVID-19. The study has not been certified by peer review.

As a result of the findings in the South Korea study, authorities said that under revised protocols, people no longer should be required to test negative for the virus before returning to work or school after they have recovered from their illness and have completed their period of isolation.

“Under the new protocols, no additional tests are required for cases that have been discharged from isolation,” the Korean CDC said in a report. The agency said it will now refer to “re-positive” cases as “PCR re-detected after discharge from isolation.”

Some coronavirus patients have tested positive again for the virus up to 82 days after becoming infected. Almost all of the cases for which blood tests were taken had antibodies against the virus.
 

Heliobas Disciple

TB Fanatic
(fair use applies)

More evidence emerges on why covid-19 is so much worse than the flu
By Lenny Bernstein
May 21 at 8:05 PM

Researchers who examined the lungs of patients killed by covid-19 found evidence that it attacks the lining of blood vessels there, a critical difference from the lungs of people who died of the flu, according to a report published Thursday in the New England Journal of Medicine.

Critical parts of the lungs of patients infected by the novel coronavirus also suffered many microscopic blood clots and appeared to respond to the attack by growing tiny new blood vessels, the researchers reported.

The observations in a small number of autopsied lungs buttress reports from physicians treating covid-19 patients. Doctors have described widespread damage to blood vessels and the presence of blood clots that would not be expected in a respiratory disease.

“What’s different about covid-19 is the lungs don’t get stiff or injured or destroyed before there’s hypoxia,” the medical term for oxygen deprivation, said Steven J. Mentzer, a professor of surgery at Harvard Medical School and part of the team that wrote the report. “For whatever reason, there is a vascular phase” in addition to damage more commonly associated with viral diseases such as the flu, he said.

The research team compared seven lungs of patients who died of covid-19, the disease caused by the coronavirus, with lung tissue from seven patients who died of pneumonia caused by the flu. They also examined 10 lungs donated for transplant but not used. The lungs, acquired in Europe, were matched by age and gender.

They did not look at blood vessels in organs such as the kidneys and heart, where other researchers have described finding attacks from the virus and unexpected blood clots.

In larger blood vessels of the lungs, the number of blood clots was similar among covid-19 and flu patients, the researchers wrote. But in covid-19 patients, they found nine times as many micro-clots in the tiny capillaries of the small air sacs that allow oxygen to pass into the blood stream and carbon dioxide to move out. The virus may have damaged the walls of those capillaries and blocked the movement of those gases, the researchers wrote.

They also found inflamed and damaged cells in the lining of blood vessels in the covid-19 patients.

Most surprising was evidence that the lungs of people attacked by the SARS-CoV-2 virus grew new blood vessels.

“The lungs from patients with covid-19 had significant new vessel growth,” a discovery the researchers described as “unexpected.” In an interview, Mentzer speculated that may have been an attempt by the lungs to pass more oxygen to hypoxic tissue.

“That may be one of the things that gets people better,” he said.

The researchers looked for genetic and other differences that might help predict who is most susceptible to severe illness from the virus but did not find any in their tiny sample. So far in the pandemic, covid-19 has hit certain groups, including older people, African Americans and people with underlying diseases such as diabetes, the hardest.

“Patients who do fairly well have a purely respiratory disease, and the patients who have trouble have a vascular component as well,” Mentzer said. But efforts to determine or explain who will fall into each group have not panned out, he said.
 

Heliobas Disciple

TB Fanatic

Why a New Virus Cluster in China Is Triggering Alarms
Bloomberg News
May 21, 2020 4:43 AM

A cluster of Covid-19 cases in China’s Rust Belt region has intensified worry over a second wave of coronavirus infections. The central and local leadership have instituted strict measures, including halting public transport services for more than 100 million people and sealing off residential compounds in some cities, as Chinese President Xi Jinping called for strengthened controls. While many other countries are still grappling with the first wave of outbreak, this re-emergence in China, while still small, is putting the world on alert.

1. How did the new cluster erupt?

The first case was reported May 7 in the northeastern province of Jilin, on the border with Russia and North Korea, and as of May 21 had spread to at least 46 people, all linked with each other. Officials have yet to identify “patient zero,” but suspects include a woman who works in the laundry at a police station in the city of Shulan, and may have been in contact with one or more people from Russia, which is behind only the U.S. in number of confirmed cases. One of China’s top doctors said patients in Jilin appeared to be asymptomatic for a longer period than was usual in Wuhan, where the coronavirus emerged last year, but didn’t elaborate on what those findings were based on. He told state television the cases in the first two weeks seem to show damage mostly in the lungs, with only 10% developing into critical cases.

2. What’s the response been?


The northeast cluster is tiny compared to the earlier outbreak in central Hubei province, where Wuhan is located. (More than 68,000 people were infected there; its 11-week lockdown ended April 8.) Yet Beijing is taking the outbreak just as seriously. Jilin city is already setting up an emergency response that could turn two stadiums into hospitals in 24 hours. The Chinese government is eager to show stability as its annual political meeting is set to convene this week, with top leaders gathering to assess economic growth in the wake of the pandemic.

3. Why is this outbreak such a worry?

The pathogen’s makeup. These coronavirus cases are showing a different gene sequence from the outbreak in Hubei, while identical with imported cases from Russia. Changes in the virus’s genetic sequence could make it harder for officials to detect. It also would create hurdles for vaccine research and development for pharmaceutical companies that are racing to stop the spread of Covid-19. Researchers worldwide are studying whether the virus is mutating in a significant way to become more contagious, but the likelihood of that has been called overstated in some early research.

4. What’s the economic impact?

The relatively poor region is often viewed as China’s Rust Belt due to the decline of heavy industry there such as automobiles. In 2019, total gross domestic product of the three provinces in the region -- Jilin, Liaoning and Heilongjiang -- stood at less than half of prosperous Guangdong province to the south, home to many giant tech companies and factories. The virus outbreak could add further pressure to the economic redevelopment campaign for the area that central government has been focusing on for years.

5. What does this show about China’s approach?

Since the Wuhan lockdown, China has been aggressive in virus testing, and is signaling that it will react with a hammer to every cluster, implementing stricter measures as needed to contain spread. That is a different approach from other economies such as South Korea and Hong Kong, which have refrained from any lockdown despite new clusters found in clubs and medical centers. Such harsh methods would be more complicated, however, if infections appear in more economically important provinces or the top cities.
 

Melodi

Disaster Cat
Doing nothing: I think we have several examples now of what happens when absolutely nothing (or very little) is or can be done - that Brazil, South Africa, Ecuador, and now parts of India (India tried but their population is too poor and too vast).

Even Sweden's government is admitting they fell down on the job when it came to the elderly and disabled - lesson there, at the very least countries newly facing this disease or a second wave, should go out of their way to protect the elderly, disabled and those with serious underlying health issues.

That not only protects those who are most at risk, but it also helps protect everyone else while at the same time opening the possibility to keep the economy going.

As often happens, common sense is what is being lost here when a disease becomes a world-wide political football.

And as someone who hasn't been out of the house (except our own on six acres) since about the middle of February, I understand it isn't fun to be one of those who needs "protecting" but I am also glad our housemate takes precautions when doing the weekly shopping (as she is doing today) wearing a mask, covering her hair and taking a shower when she gets back home.

Again, that helps protect me, her and the shop workers she interacts with - no politics involved, just common sense.

Trump can say all he likes about "we will not shut the country down a second time" and I suspect with good planning and a common-sense approach that is likely UNLESS a new version of the virus (like the one in North-Eastern China) proves to be much more dangerous to a larger group (working-age folks or kids) of people.

Then, well as I've mentioned before, things may shut down with or without "permission" or anything "official" happening, because one thing 1918 and the 6th, 14th, 16th-century outbreaks of disease have taught the world is that if people become sick enough to frighten everyone else sufficiently people do just drop tools and either run to the countryside or lock themselves in their houses.

I hope that does not happen, but I also don't think we should take the good luck and thankfully low infections rates in parts of the US (and parts of Europe) as a definitive that a second wave (or future disease) may not turn places like Kansas City or Holly Springs Mississippi into Ecuador or Italy.
 

Troke

On TB every waking moment
(fair use applies)

'Reopening' won't fix the economy. Beating the virus will.
David Plotz and Henry Blodget
12 hours ago

'Reopening' won't fix our economy. What will fix it are declining cases and deaths.
As the political fight about "health versus the economy" continues, it's worth repeating: It's not one or the other. It's both.
Reopening is an important and meaningful step. But even when everything is open, our economy won't recover until people feel safe resuming their normal lives.

"Most of the slowdown occurred due to voluntary social distancing rather than lockdowns," Bank of America Merrill Lynch economists concluded this week.

Charts from the excellent economics site Calculated Risk confirm this.

Take the number of TSA airport safety checks this year (red) versus last year (blue). There have never been formal restrictions on air travel in the US. But flying is perceived as risky. And even now air travel is only about 10% of normal levels.

Screen Shot 2020 05 21 at 9.11.30 AM

Calculated Risk

Similarly, restaurants in many states are now open again. Some diners are returning, especially in states that began opening a few weeks ago. But we're still only a tiny fraction of normal.


Screen Shot 2020 05 21 at 9.09.49 AM

Calculated Risk

Other charts at Calculated Risk show the same trends. Hotel occupancy is still way below normal, for example. Movie-theater attendance is flatlined at zero.

If reopening won't fix our economy, what will? People seeing that the risk to themselves and their families and friends is low.

As we relax restrictions, we must continue to do everything we reasonably can to reduce the spread of the virus — namely, distancing, mask wearing, handwashing, and increasing our testing, tracing, and isolation capabilities. —HB

Sweden's looser restrictions have not saved its economy

Those who blame lockdowns for the state of the economy often point to Sweden as a country that has taken a smarter and more balanced approach.

Sweden does have restrictions — large gatherings are banned and distancing is encouraged — but schools and businesses are open.

The price Sweden has paid for this looser approach is well known: a lot more death.

Economists at Morgan Stanley charted the death rate per million in Sweden (yellow) as compared to Denmark (black), a country that took a more restrictive approach:

Screen Shot 2020 05 21 at 9.42.40 AM

Morgan Stanley

Sweden's sacrifice is sometimes framed as a more reasonable balance between health and the economy. After all, life is risky, Sweden's boosters say, and most of the people who've died were older people who would have died soon.
But here's the part that Sweden advocates often miss.

Sweden's economy has still been demolished.

A new paper concludes that, despite the looser restrictions, consumer spending in Sweden has dropped 25% from normal levels. Spending in Denmark has dropped just 4 points more — 29%. The looser restrictions haven't made much difference.

As Sweden's death rate continues to climb — and as the country remains miles from the nirvana of "herd immunity" — experts in Sweden are increasingly speaking out about their frustration with the country's approach. One of these experts told Insider's Sinead Baker that Sweden's approach is "not something anyone should copy."

Morgan Stanley draws the same conclusion from the Sweden and Denmark data that we and others have been articulating for weeks:

"The economic downturn has been primarily because of the virus. Ending lockdowns is not a panacea." —HB

Meanwhile in Japan

Those advocating for looser restrictions should focus instead on Japan. Despite looser lockdowns than elsewhere — and despite having large numbers of older people — Japan's death and infection rates are low.

Why? Perhaps because of the country's commitment to hygiene and mask wearing.

In Japan, and elsewhere, people are increasingly resuming their normal lives. They're just doing it in masks. —HB
I been ranting since the beginning that until people feel safe in their work, they won't come back and neither will the customers. And if we have to wait for a vaccine, we are going to wait a long time. Medication is the way to go but there seems to be little effort along that line compared to the zillions spent on vaccines.
 

Mixin

Veteran Member
Cases of child inflammatory syndrome possibly linked to coronavirus grow in Indiana, IU Health says
by: FOX59 Web, CNN Wire
Posted: May 22, 2020 / 06:05 AM EDT / Updated: May 22, 2020 / 07:59 AM EDT

INDIANAPOLIS — We now know the number of children with multisystem inflammatory syndrome is growing in Indiana. That illness may be linked to COVID-19.

The state health department confirmed one case earlier this week, but IU Health now confirms there are multiple cases.

Symptoms do not look like the classic symptoms of coronavirus and may mostly include stomach pain and vomiting, along with fever and perhaps a rash, the experts told other doctors during a meeting Tuesday organized by the US Centers for Disease Control and Prevention.

It’s becoming clear that many of the children with the new syndrome have damage to their hearts and need immediate treatment, they said at the Clinician Outreach and Communication Activity (COCA) briefing. They believe it’s increasingly clear COVID-19 is involved, even though many of the children test negative for the virus at first and never seemed to have had symptoms of infection.

The syndrome appears to develop two to six weeks after infection with Covid-19 and affects mostly children who were perfectly healthy beforehand. The CDC issued a health alert last week warning pediatricians to be on the lookout, and at least 20 states plus Washington, DC have reported they are investigating possible cases.

If your child shows more serious symptoms—like trouble breathing or chest pain—take them to the emergency room right away.

 

inskanoot

Veteran Member
FWIW —


ThinQing Anon
@ThinQingAnon

1. HOME RECIPE FOR HYDROXYCHLOROQUINE (HCQ):

THE DRUG THAT IS CURRENTLY TREATING THIS VIRUS…..WATCH BELOW AS I SHOW YOU THE RECIPE AND HOW TO MAKE THIS SOLUTION AT HOME, MINUS BIG PHARMAS FILLERS AND PRESERVATIVES.

2. THAT’S RIGHT……..THIS IS THE REAL REASON THAT THE DRUG COMPANIES WERE FURIOUS ABOUT THIS CURE. NOT ONLY HAS IT PROVEN TO ELIMINATE THIS VIRUS….BUT OTHERS AS WELL. IT WAS SUPPOSED TO BE A BIG KEPT SECRET…BUT TRUMP BLEW THAT FOR THEM RIGHT AWAY.

3. WHAT IS HYDROXYCHLOROQUINE EXACTLY? IT IS NOTHING BUT QUININE. SOMETHING THAT ANYONE CAN MAKE AT HOME….AND SOMETHING THAT IS BEING MANUFACTURED EACH AND EVERY DAY IN THE FORM OF SOMETHING WE HAVE ALL SEEN AT THE GROCERY AND LIQUOR STORES………NONE OTHER THAN TONIC WATER.

4. THIS DRUG BEING USED TO TREAT THE COVID VIRUS HAS. THIS WAS NEVER SUPPOSED TO BE LEAKED OUT…BECAUSE EVEN A FULL TREATMENT REGIME OF PILLS FROM THE DOCTOR IS LESS THAN A 100.00 FOR SOMEONE THAT DOES NOT HAVE INSURANCE.

5. SOMETHING ELSE YOU MAY FIND INTERESTING IS THAT WHEN THEY CREATED THIS VIRUS, THEY ALSO PUT A STRAIN OF HIV IN IT. THIS WAS TO MAKE IT EVEN MORE FATAL. BUT... GUESS WHAT?

6. THE QUININE KILLED THAT PART OF THE AIDS VIRUS AS WELL. CAN YOU SEE NOW WHY THEY WERE SCREAMING THAT THIS WAS A DANGEROUS DRUG AND NOT TO DARE USE IT. BEHIND THE SCENE STUDIES ARE NOW COMING FORTH THAT SHOW IT BEING EFFECTIVE OTHER DISEASES AS WELL AND EVEN ON CANCERS.

7. I THINK IN THE DAYS TO COME, WE ARE GOING TO FIND OUT A WHOLE LOT MORE THAN WE EVER THOUGHT WE KNEW. IF YOU LISTENED TO OUR PRESIDENT THIS WEEK, HE SAID THAT “IN ONE YEAR, EVERY TREATMENT THAT WE ARE NOW USING IN THE HOSPITALS WILL BE OBSOLETE”. WHAT DOES HE KNOW?

8. HE KNOWS THAT THEY HAVE WITHHELD THESE CURES TO KEEP PEOPLE SICK AND TO MAKE MILLIONS OFF OF INSURANCE COMPANIES.

9. QUININE HAS MANY USES AND APPLICATIONS. IT IS ANALGESIC, ANESTHETIC, ANTIARRHYTHMIC, ANTIBACTERIAL, ANTIMALARIAL, ANTIMICROBIAL, ANTIPARASITIC, ANTIPYRETIC, ANTISEPTIC, ANTISPASMODIC, ANTIVIRAL, ASTRINGENT, BACTERICIDE, CYTOTOXIC, FEBRIFUGE, FUNGICIDE, INSECTICIDE, NERVINE,

10. STOMACHIC, TONIC…….SO YOU CAN BE SURE THAT BIG PHARMA IS SCARED TO DEATH AT THIS POINT AND SCREAMING THAT THIS DRUG DOES NOT WORK…WHEN THE ENTIRE WORLD SEES THAT IT IS WORKING.

11. IF YOU EVER FEEL A CHEST COLD COMING ON OR JUST FEEL LIKE CRAP…. MAKE YOUR OWN QUININE. IT IS MADE OUT OF THE PEELINGS OF GRAPEFRUITS AND LEMONS, …BUT ESPECIALLY GRAPEFRUITS. I WILL GIVE YOU THE RECIPE HERE AND YOU TAKE THIS CONCOCTION THROUGHOUT THE DAY…

12. OR YOU CAN MAKE A TEA OUT OF IT AND DRINK IT ALL DAY. THIS SHOULD TAKE AWAY ALL YOUR FEARS ABOUT THIS VIRUS, BECAUSE YOU NOW HAVE THE DEFENSE AGAINST IT AND MANY OTHER THINGS.

13. IF YOU TAKE ZINC WITH THIS RECIPE, THE ZINC PROPELS THE QUININE INTO YOUR CELLS FOR A MUCH FASTER HEALING.

14. HERE IS ALL YOU NEED TO DO TO MAKE YOUR VERY OWN QUININE……………………………TAKE THE RIND OF 2-3 GRAPEFRUITS. TAKE THE PEEL ONLY AND COVER IT WITH WATER ABOUT 3 INCHES ABOVE THE PEELS.PUT A GLASS LID ON YOUR POT IF YOU HAVE ONE….A METAL ONE IS FINE IF YOU DON’T.

15. LET IT SIMMER FOR ABOUT 2 HOURS. DO NOT TAKE THE LID OFF OF THE POT TILL IT COOLS COMPLETELY AS THIS WILL ALLOW THE QUININE TO ESCAPE IN THE STEAM.

16. SWEETEN THE TEA WITH HONEY OR SUGAR SINCE IT WILL BE BITTER. TAKE 1 TABLESPOON EVERY COUPLE OF HOURS TO BRING UP THE PHLEGM FROM YOUR LUNGS. DISCONTINUE AS SOON AS YOU GET BETTER.

17. PLEASE SHARE THIS WITH THOSE THAT NEED TO REDUCE FEAR AND ALLOW THEM TO SEE THAT GOD IN ALL OF HIS GLORY, PROVIDES US WITH ALL THAT WE NEED

18. JUST FOR TRUTHS SAKE, LET IT BE KNOWN THAT IN ADDITION TO THIS, DOCTORS ARE ALSO PRESCRIBING THE ANTIBIOTIC AZYTHROMICIN (ZPACK). FOR THE RECORD, I AM NOT A DOCTOR OF ANY SORTS AND ONLY OFFER THIS FROM MY OWN DATA RESEARCH.

19. I AM NOT PRESCRIBING THIS IN ANY WAY, AND IT IS UP TO THE INDIVIDUAL READING THIS TO DO WITH THIS INFORMATION WHAT THEY WANT, IN ACCORDANCE WITH OUR FREEDOM FROM THE UNITED STATES CONSTITUTION.

Thread by @ThinQingAnon: 1. HOME RECIPE FOR HYDROXYCHLOROQUINE (HCQ): THE DRUG THAT IS CURRENTLY TREATING THIS VIRUS…..WATCH BELOW AS I SHOW YOU THE RECIPE AND HOW T…
 
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20Gauge

TB Fanatic
Doing nothing: I think we have several examples now of what happens when absolutely nothing (or very little) is or can be done - that Brazil, South Africa, Ecuador, and now parts of India (India tried but their population is too poor and too vast).

Even Sweden's government is admitting they fell down on the job when it came to the elderly and disabled - lesson there, at the very least countries newly facing this disease or a second wave, should go out of their way to protect the elderly, disabled and those with serious underlying health issues.

That not only protects those who are most at risk, but it also helps protect everyone else while at the same time opening the possibility to keep the economy going.

As often happens, common sense is what is being lost here when a disease becomes a world-wide political football.

And as someone who hasn't been out of the house (except our own on six acres) since about the middle of February, I understand it isn't fun to be one of those who needs "protecting" but I am also glad our housemate takes precautions when doing the weekly shopping (as she is doing today) wearing a mask, covering her hair and taking a shower when she gets back home.

Again, that helps protect me, her and the shop workers she interacts with - no politics involved, just common sense.

Trump can say all he likes about "we will not shut the country down a second time" and I suspect with good planning and a common-sense approach that is likely UNLESS a new version of the virus (like the one in North-Eastern China) proves to be much more dangerous to a larger group (working-age folks or kids) of people.

Then, well as I've mentioned before, things may shut down with or without "permission" or anything "official" happening, because one thing 1918 and the 6th, 14th, 16th-century outbreaks of disease have taught the world is that if people become sick enough to frighten everyone else sufficiently people do just drop tools and either run to the countryside or lock themselves in their houses.

I hope that does not happen, but I also don't think we should take the good luck and thankfully low infections rates in parts of the US (and parts of Europe) as a definitive that a second wave (or future disease) may not turn places like Kansas City or Holly Springs Mississippi into Ecuador or Italy.
We are planning as if this will happen. All the while hoping to no end that it doesn't
 

Mixin

Veteran Member
They need to find some way to stop them at the door. Ford is having a similar problem.

Nearly 600 workers from North Carolina Tyson chicken processing plant test positive for COVID-19
by: Brya Berry
Posted: May 22, 2020 / 12:36 AM EDT / Updated: May 22, 2020 / 12:36 AM EDT

Wilkes County, North Carolina — Almost 600 workers at a Tyson chicken plant that reopened after being closed for deep cleaning have tested positive for COVID-19, reports CBS Charlotte affiliate WBTV.

Tyson said 570 employees and contractors out of 2,244 from the Wilkesboro plant who were tested came up positive.

A majority didn’t have symptoms and wouldn’t have known they were infected if they hadn’t been tested, the company added.

The plant had shut down for five days as a result of a COVID-19 outbreak.

Of the 570, 237 were tested by the Department of Health or their own health care providers. Another 2,007 were tested onsite from May 6 to May 9.

Two of the three plants at the Tyson complex were shut down for cleaning. The Fresh Plant One facility was closed earlier this month.

Outbreaks at chicken and meat processing plants are among the main virus clusters around the country.

Tyson said workers who test positive receive paid leave and only return to work after they meet CDC and Tyson criteria. Company policy requires that all those testing positive or feeling sick be isolated at home.

“We are working closely with local health departments to protect our team members and their families, and to help manage the spread of the virus in our communities,” said Tom Brower, Senior Vice President of Health and Safety for Tyson Foods. “We are using the most up-to-date data and resources to support our team members, and we are committed to ensuring they feel safe and secure when they come to work.”

***************************
Ford temporarily closes two plants after three workers test positive for coronavirus
PUBLISHED WED, MAY 20 202012:18 PM EDTUPDATED WED, MAY 20 202011:14 PM EDT
Michael Wayland@MIKEWAYLAND

KEY POINTS:
Ford closed and then reopened its Chicago Assembly plant twice in less than 24 hours after two workers tested positive for Covid-19.
The company said the employees did not contract the disease while at work, citing the incubation time of the disease.
The infected workers are being asked to self-quarantine for 14 days.

More:
 

Plain Jane

Just Plain Jane

COVID-19 Data for Pennsylvania*
* Map, tables, case counts and deaths last updated at 12:00 p.m. on 5/22/2020
Source: Pennsylvania National Electronic Disease Surveillance System (PA-NEDSS) as of 12:00 a.m. on 5/22/2020
Page last updated: 12:00 p.m. on 5/22/2020


Case Counts, Deaths, and Negatives
Total Cases*DeathsNegative**
66,2584,984312,743


* Total case counts include confirmed and probable cases.
** Negative case data only includes negative PCR tests. Negative case data does not include negative antibody tests.




Hospital Data
Trajectory Animations


Positive Cases by Age Range to Date
Age RangePercent of Cases*
0-4< 1%
5-12< 1%
13-182%
19-246%
25-4937%
50-6426%
65+29%
* Percentages may not total 100% due to rounding


Hospitalization Rates by Age Range to Date


Age RangePercent of Cases*
0-4< 1%
5-12< 1%
13-18< 1%
19-241%
25-4916%
50-6426%
65+57%


* Percentages may not total 100% due to rounding


Death Data



County Case Counts to Date
CountyTotal CasesNegatives
Adams2142418
Allegheny173925517
Armstrong581099
Beaver5503122
Bedford 36601
Berks38389867
Blair462292
Bradford431272
Bucks476416192
Butler2093325
Cambria553042
Cameron2116
Carbon2241948
Centre1381763
Chester23209921
Clarion25628
Clearfield33918
Clinton48474
Columbia3421139
Crawford21964
Cumberland5723674
Dauphin10498426
Delaware606017041
Elk6280
Erie1903658
Fayette932797
Forest763
Franklin6974463
Fulton14186
Greene27688
Huntingdon223719
Indiana891103
Jefferson7453
Juniata94293
Lackawanna14515040
Lancaster273613286
Lawrence731115
Lebanon8923926
Lehigh361312182
Luzerne26209271
Lycoming1551915
McKean11474
Mercer1021303
Mifflin571076
Monroe12954885
Montgomery636628819
Montour503105
Northampton284211306
Northumberland1551205
Perry43579
Philadelphia1705748077
Pike4751807
Potter4126
Schuylkill5603881
Snyder35341
Somerset371431
Sullivan280
Susquehanna93600
Tioga16474
Union61909
Venango8448
Warren3313
Washington1343713
Wayne115833
Westmoreland4368001
Wyoming33387
York89511373



Incidence by County


Incidence%20by%20County.png

Incidence is calculated by dividing the current number of confirmed and probable COVID-19 cases reported to the Department by the 2018 county population data available from the Bureau of Health Statistics. The counties are divided into 6 relatively equally-sized groups based on their incidence rate (i.e. sestiles). Cases are determined using a national COVID-19 case definition. There currently is no way to estimate the true number of infected persons. Incidence rates are based on the number of known cases, not the number of true infected persons.


Case Counts by Sex to Date











SexPositive Cases Percent of Cases*
Female36,42055%
Male29,15344%
Neither30%
Not reported6821%
* Percentages may not total 100% due to rounding

Case Counts by Race to Date*







RacePositive CasesPercent of Cases
African American/Black793012%
Asian8851%
White17,51826%
Other3661%
Not reported39,55960%
* 60% of race is not reported. Little data is available on ethnicity.
** Percentages may not total 100% due to rounding



Case Counts by Region to Date








RegionPositiveNegativeInconclusive
Northcentral 9881280317
Northeast1248748259140
Northwest4131073318
Southcentral46634002675
Southeast42772147084887
Southwest32285383844

EpiCurve by Region


EpiCurve%20by%20Region.png

Case counts are displayed by the date that the cases were first reported to the PA-NEDSS surveillance system. Case counts by date of report can vary significantly from day to day for a variety of reasons. In addition to changes due to actual changes in disease incidence, trends are strongly influenced by testing patterns (who gets tested and why), testing availability, lab analysis backlogs, lab reporting delays, new labs joining our electronic laboratory reporting system, mass screenings, etc. Trends need to be sustained for at least 2-3 weeks before any conclusions can be made regarding the progress of the pandemic.

COVID-19 Cases Associated with Nursing Homes and Personal Care Homes to Date
This data represents long-term care facilities in Pennsylvania, including Department of Health and Department of Human Services regulated facilities.
 

Trivium Pursuit

Has No Life - Lives on TB
(fair use applies)

More evidence emerges on why covid-19 is so much worse than the flu
By Lenny Bernstein
May 21 at 8:05 PM

Researchers who examined the lungs of patients killed by covid-19 found evidence that it attacks the lining of blood vessels there, a critical difference from the lungs of people who died of the flu, according to a report published Thursday in the New England Journal of Medicine.

Critical parts of the lungs of patients infected by the novel coronavirus also suffered many microscopic blood clots and appeared to respond to the attack by growing tiny new blood vessels, the researchers reported.

The observations in a small number of autopsied lungs buttress reports from physicians treating covid-19 patients. Doctors have described widespread damage to blood vessels and the presence of blood clots that would not be expected in a respiratory disease.

“What’s different about covid-19 is the lungs don’t get stiff or injured or destroyed before there’s hypoxia,” the medical term for oxygen deprivation, said Steven J. Mentzer, a professor of surgery at Harvard Medical School and part of the team that wrote the report. “For whatever reason, there is a vascular phase” in addition to damage more commonly associated with viral diseases such as the flu, he said.

The research team compared seven lungs of patients who died of covid-19, the disease caused by the coronavirus, with lung tissue from seven patients who died of pneumonia caused by the flu. They also examined 10 lungs donated for transplant but not used. The lungs, acquired in Europe, were matched by age and gender.

They did not look at blood vessels in organs such as the kidneys and heart, where other researchers have described finding attacks from the virus and unexpected blood clots.

In larger blood vessels of the lungs, the number of blood clots was similar among covid-19 and flu patients, the researchers wrote. But in covid-19 patients, they found nine times as many micro-clots in the tiny capillaries of the small air sacs that allow oxygen to pass into the blood stream and carbon dioxide to move out. The virus may have damaged the walls of those capillaries and blocked the movement of those gases, the researchers wrote.

They also found inflamed and damaged cells in the lining of blood vessels in the covid-19 patients.

Most surprising was evidence that the lungs of people attacked by the SARS-CoV-2 virus grew new blood vessels.

“The lungs from patients with covid-19 had significant new vessel growth,” a discovery the researchers described as “unexpected.” In an interview, Mentzer speculated that may have been an attempt by the lungs to pass more oxygen to hypoxic tissue.

“That may be one of the things that gets people better,” he said.

The researchers looked for genetic and other differences that might help predict who is most susceptible to severe illness from the virus but did not find any in their tiny sample. So far in the pandemic, covid-19 has hit certain groups, including older people, African Americans and people with underlying diseases such as diabetes, the hardest.

“Patients who do fairly well have a purely respiratory disease, and the patients who have trouble have a vascular component as well,” Mentzer said. But efforts to determine or explain who will fall into each group have not panned out, he said.
This is the kind of in depth research and analysis's that's going to lead to better treatments. This is the important stuff not screwing around trying to find a vaccine.,
 

raven

TB Fanatic
I been ranting since the beginning that until people feel safe in their work, they won't come back and neither will the customers.

And if we have to wait for a vaccine, we are going to wait a long time. Medication is the way to go but there seems to be little effort along that line compared to the zillions spent on vaccines.
That sounds reasonable and logical except people defy the premise at both work and play.
I don't think people actually consider their safety at work
. . . unless they have one of those near death experiences
and most times, if they don't die
. . . they just keep doing it.

they jump out of perfectly good airplanes . . . on purpose. They dive off cliffs with reckless abandon. They crash an airplane and then go out an fly another one. You look out the window 12 miles out over the Barents Sea and there is a Soviet SU-27 15ft off the wing . . . and everyone is taking pics because you got a first time intercept - and two days later, you do it again. They race cars.

They left the comforts of civilization and moved west where there was nothing and built new lives.

Humans not only defy death they have a penchant for seeking out new ways to do so. So I do not think "being safe at work" will be as big a factor as assumed.

People will go to work when their desire for money is greater than their desire for security.
 

marsh

On TB every waking moment
View: https://www.youtube.com/watch?v=XXLL7kh-Un8
17:20 min
The Use of Investigational Drugs in an Outbreak: Separating Science and Politics With...
•May 22, 2020

Johns Hopkins Bloomberg School of Public Health
The use of investigational drugs during a public health crisis is not new. In 2014, Dr. Linda Mobula had experience administering an untested drug during the Ebola response in West Africa. Mobula talks to Dr. Josh Sharfstein about how the technical framework that came out of that process could have been used to provide guidance for investigational drugs in COVID-19, and how political figures created a global push for hydroxychloroquine.

__________________-

View: https://www.youtube.com/watch?v=a4Po0YSea5M
6:58 min
Dr. Caitlin Rivers from the Center for Health Security Answers More COVID-19 Questions
•May 22, 2020


Johns Hopkins Bloomberg School of Public Health
Is Vitamin D deficiency correlated with severe outcomes? Is it safe to use dry bat guano fertilizer? People in my area seem to be social distancing, so why are there still so many cases? If I received a flu shot, will it help protect me from severe illness with coronavirus? Dr. Caitlin Rivers of the Johns Hopkins Center for Health Security addresses your questions submitted to publichealthquestion@jhu.edu
 

marsh

On TB every waking moment
View: https://www.youtube.com/watch?v=91tZOcvvpBo
58:30 min
Ep 189- Pandemic: You Ain't Black (w/ Christopher Iacovella)
•Streamed live 5 hours ago


Bannon WarRoom - Citizens of the American Republic

Steve Bannon, Jack Maxey, Jason Miller, and Raheem Kassam discuss the latest on the coronavirus pandemic as Joe Biden does a host of interviews in the morning a provides a number of suspect responses. Calling in is Christopher Iacovella to discuss the Senate passing legislation to de-list CCP backed companies from the US exchanges 100-0.

_____________________

View: https://www.youtube.com/watch?v=rDEtBnngzh0
58:00 min
Ep 190- Pandemic: Private Dinners with Xi (w/ Frank Gaffney)
•Streamed live 4 hours ago



Bannon WarRoom - Citizens of the American Republic

Steve Bannon, Jack Maxey, Jason Miller, and Raheem Kassam discuss the latest on the coronavirus pandemic as the team continues to deconstruct Joe Biden's relationship with the Chinese Communist Party. Calling in is Frank Gaffney to discuss how the CCP needs to be rooted out of American capital markets.
 

marsh

On TB every waking moment
View: https://www.youtube.com/watch?v=-zK8LgVx2G8
8:53 min
Coronavirus Pandemic Update 74: Vitamin D & COVID 19; Academic Censorship
•May 22, 2020

MedCram - Medical Lectures Explained CLEARLY
COVID-19 Update 74 with Roger Seheult, MD. All coronavirus updates available free at our website https://www.medcram.com/courses/coron... In this video, Dr. Seheult reviews a new article from the Lancet discusses the potential benefit and role of Vitamin D in preventing and reducing the severity of COVID-19. The censorship of academic discussion about studies and peer-reviewed journal articles has become an area of significant concern for medical professionals and those seeking evidence-based information during a pandemic. Dr. Seheult shares his opinion on this type of censorship, and also shares resources for dental professionals preparing to open their practices. (This video was recorded on May 22, 2020) -

------------ Links referenced in this video: Johns Hopkins Tracker - https://coronavirus.jhu.edu/map.html Worldometer https://www.worldometers.info/coronav... Lancet Article on Vitamin D - https://www.thelancet.com/journals/la... TILDA Study - https://tilda.tcd.ie/ Australian Dental Association - https://www.ada.org.au/Covid-19-Porta... ADA Center for Professional Success - https://success.ada.org/en/practice-m... CNN - https://www.cnn.com/videos/business/2... 60 Minutes - https://www.youtube.com/watch?v=rxdln...
 

marsh

On TB every waking moment
View: https://www.youtube.com/watch?v=RgH2jtlvyDE
3:11 min
CORONAVIRUS VACCINE: WHY does it take so long to develop a cure?
•May 22, 2020

Glenn Beck
Matt Ridley, author of "How Innovation Works," tells Glenn and Stu he was surprised when scientists and doctors said it would take 12-18 months at BEST to develop a COVID-19 vaccine. Usually developing vaccines takes even longer: it was 4 YEARS total for the whooping cough cure. And the reason for such a slow process isn't just because of government oversight. Ridley says there's another reason why we'll be waiting a long time for that coronavirus cure that'll hopefully bring our daily lives a little bit closer to normal.
 

Zagdid

Veteran Member

Placentas from COVID-19-positive pregnant women show injury
Date: May 22, 2020
Source: Northwestern University
Summary: In the largest study to examine health of placentas in women who tested positive for COVID-19, findings show placentas from 16 women who tested positive for COVID-19 while pregnant showed evidence of injury, according to pathological exams completed directly following birth.

The placentas from 16 women who tested positive for COVID-19 while pregnant showed evidence of injury, according to pathological exams completed directly following birth, reports a new Northwestern Medicine study.

The type of injury seen in the placentas shows abnormal blood flow between the mothers and their babies in utero, pointing to a new complication of COVID-19. The findings, though early, could help inform how pregnant women should be clinically monitored during the pandemic.
The study was published today (May 22) in the journal American Journal of Clinical Pathology. It is the largest study to examine the health of placentas in women who tested positive for COVID-19.
"Most of these babies were delivered full-term after otherwise normal pregnancies, so you wouldn't expect to find anything wrong with the placentas, but this virus appears to be inducing some injury in the placenta," said senior author Dr. Jeffrey Goldstein, assistant professor of pathology at Northwestern University Feinberg School of Medicine and a Northwestern Medicine pathologist. "It doesn't appear to be inducing negative outcomes in live-born infants, based on our limited data, but it does validate the idea that women with COVID should be monitored more closely."

This increased monitoring might come in the form of non-stress tests, which examine how well the placenta is delivering oxygen, or growth ultrasounds, which measure if the baby is growing at a healthy rate, said co-author Dr. Emily Miller, assistant professor of obstetrics and gynecology at Feinberg and a Northwestern Medicine obstetrician.

"Not to paint a scary picture, but these findings worry me," Miller said. "I don't want to draw sweeping conclusions from a small study, but this preliminary glimpse into how COVID-19 might cause changes in the placenta carries some pretty significant implications for the health of a pregnancy. We must discuss whether we should change how we monitor pregnant women right now."

Previous research has found that children who were in utero during the 1918-19 flu pandemic, which is often compared to the current COVID-19 pandemic, have lifelong lower incomes and higher rates of cardiovascular disease. Flu doesn't cross the placenta, Goldstein said, so whatever is causing life-long problems in those people is most likely due to immune activity and injury to the placenta.

"Our study, and other studies like it, are trying to get on the ground floor for this exposure so we can think about what research questions we should be asking in these kids and what can or should we do now to mitigate these same types of outcomes," Goldstein said.

Fifteen patients delivered live infants in the third trimester, however one patient had a miscarriage in the second trimester. "That patient was asymptomatic, so we don't know whether the virus caused the miscarriage or it was unrelated," Goldstein said, "We are aware of four other cases of miscarriage with COVID. The other reported patients had symptoms and three of four had severe inflammation in the placenta. I'd like to see more before drawing any conclusions."

The placenta is the first organ to form in fetal development. It acts as the fetus' lungs, gut, kidneys and liver, taking oxygen and nutrients from the mother's blood stream and exchanging waste. The placenta also is responsible for many of the hormonal changes within the mother's body. Examining a woman's placenta allows a pathologist to follow a retroactive roadmap of a woman's pregnancy to learn what happened to the baby in utero or what could happen to both the mother and the infant after birth.

"The placenta acts like a ventilator for the fetus, and if it gets damaged, there can be dire outcomes," Miller said. "In this very limited study, these findings provide some signs that the ventilator might not work as well for as long as we'd like it to if the mother tests positive for SARS-CoV2."

The placentas in these patients had two common abnormalities: insufficient blood flow from the mother to the fetus with abnormal blood vessels called maternal vascular malperfusion (MVM) and blood clots in the placenta, called intervillous thrombi.

In normal cases of MVM, the mother's blood pressure is higher than normal. This condition is typically seen in women with preeclampsia or hypertension. Interestingly, only one of the 15 patients in this study had preeclampsia or hypertension.

"There is an emerging consensus that there are problems with coagulation and blood vessel injury in COVID-19 patients," Goldstein said. "Our finding support that there might be something clot-forming about coronavirus, and it's happening in the placenta."

The 16 women in the study delivered their babies at Northwestern Medicine Prentice Women's Hospital. All tested positive for COVID-19. Four patients came in with flu-like symptoms three to five weeks before delivery and tested positive for the virus. The remaining patients all tested positive when they came in to deliver. Five patients never developed symptoms, others were symptomatic at delivery.

Between 30 and 40 patients deliver at Prentice daily. The team began testing placentas of COVID-19-positive mothers in early April. Fourteen of the live-born infants in the study were born full term and with normal weights and Apgar scores. One live-born infant was premature.

"They were healthy, full-term, beautifully normal babies, but our findings indicate a lot of the blood flow was blocked off and many of the placentas were smaller than they should have been," Miller said. "Placentas get built with an enormous amount of redundancy. Even with only half of it working, babies are often completely fine. Still, while most babies will be fine, there's a risk that some pregnancies could be compromised."

In February, before the pandemic was known to have reached Chicago, Goldstein assembled his research team.

"If you get the flu and you're pregnant, we know nothing about what that looks like in your placenta, so I began thinking how we'd study this flu-like epidemic if it came through Chicago," Goldstein said. "We started setting things up and then lo and behold, the epidemic came here, so we were ready."

Other Northwestern co-authors include Elisheva D. Shanes, Leena B. Mithal and Hooman A. Azad.
 

marsh

On TB every waking moment
View: https://www.youtube.com/watch?v=hXNhhmKzucI
4:17 min
Moderna shares rise following Dr. Fauci's comments on Covid-19 vaccine data
•May 22, 2020


CNBC Television

Dr. Anthony Fauci, the White House’s top U.S. infectious disease expert, said Friday he is cautiously optimistic about Moderna's early-stage vaccine trial results. CNBC's Meg Tirrell reports.

______________________

View: https://www.youtube.com/watch?v=VExJSP5C24A
8:08 min
Dr. Fauci: Many Covid-19 vaccine candidates in the works
•May 22, 2020


CNBC Television


CNBC's Meg Tirrell talks with White House advisor Dr. Anthony Fauci about the coronavirus vaccine trials, reopening the economy and more.

_____________________________
View: https://www.youtube.com/watch?v=DU9ULW8o8Nk
7:21 min
Producing vaccine a year after virus identified 'mind boggling': Emory professor
•May 22, 2020



CNBC Television


Dr. Carlos del Rio, Emory University’s School of Medicine professor and executive associate dean, joins 'Power Lunch' to discuss how likely it is a vaccine for the novel coronavirus will be developed.
 
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marsh

On TB every waking moment
View: https://www.youtube.com/watch?v=D9vT0oFcFig
LIVE
New York Gov. Andrew Cuomo holds a briefing on the coronavirus outbreak — 5/22/2020
•Streamed live 5 hours ago



CNBC Television

New York Gov. Andrew Cuomo is holding his daily press conference on the Covid-19 outbreak, which has infected more than 356,458 people across the state, according to data compiled by Johns Hopkins University. Cuomo said Thursday that New York public schools should start preparing plans to reopen this fall, but it’s too early to know for sure whether that will happen. »
 

marsh

On TB every waking moment

marsh

On TB every waking moment
View: https://www.youtube.com/watch?v=WoalOxsNexc
4:14 min
Why has Brazil been so badly hit by coronavirus?
•May 22, 2020


Guardian News
The spread of coronavirus has been catastrophic in Brazil, with the country now ranking third for infections behind only the US and Russia. The infection rate has been growing rapidly in Latin America, and as global infections passed 5 million, Brazil reported a record 19,951 cases on 20 May, according to the ministry of health, taking total infections to 291,579. From a sceptical president to a healthcare system on the verge of collapse, the Guardian's Tom Phillips explains the factors that have put Brazil at risk of becoming the next epicentre of the virus

__________________--

View: https://www.youtube.com/watch?v=WMh8wdpAhNg
2:18 min
Brazil buckles under coronavirus crisis, Mexico reels from potentially higher death toll l ABC News
•May 20, 2020


ABC News

Officials reported just over 1,300 deaths in Mexico City, but an anti-corruption group examined death certificates and said the numbers could be three times higher.
 
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marsh

On TB every waking moment
View: https://www.youtube.com/watch?v=tMLK-kBjJwM
15:59 min
Nearly 39 Million Americans File For Unemployment During Pandemic | NBC News NOW
•May 21, 2020


NBC News
NBC News’ Stephanie Ruhle beaks down the new unemployment numbers after an additional 2.4 million Americans file for unemployment as census bureau data shows 47.5 percent of all adults live in a household that has lost income during the pandemic.
 

marsh

On TB every waking moment
View: https://www.youtube.com/watch?v=SrtZKnQysyY
5:18 min
The coronavirus is mutating. But don’t freak out yet.
•May 20, 2020



Verge Science

The coronavirus, SARS-CoV-2, is mutating. It’s true, but that’s not necessarily a bad thing. It sounds concerning — if the virus is changing, that could imply that it’s getting worse. That’s not the case. Although it’s true that the coronavirus is mutating, that doesn’t mean it’s getting more dangerous. In fact, it can help us in our battle against the COVID-19 pandemic. Here’s how. Read more: https://bit.ly/2LPCfZH Further reading: https://nextstrain.org/ https://www.theatlantic.com/health/ar... https://www.nytimes.com/interactive/2...
 

marsh

On TB every waking moment
View: https://www.youtube.com/watch?v=iQ9j6jgO5tw
3:04 min
Coronavirus: South Africa's alcohol and cigarette lockdown - BBC News
•May 22, 2020

BBC News

Since the start of the coronavirus pandemic, the world has seen lockdowns in many countries. In South Africa, not only have people been told to stay at home, but exercise outside was banned for some time - and cigarettes and alcohol still can't be purchased. What is the impact of such a ban and how do people feel about it? The BBC's Andrew Harding reports.
 
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