etdeb... st johnswort does work for mild to moderate depression for many people. However, DO NOT start taking it until you are off other anti-depressants. While I don't think Wellbutrin is a MAO inhibitor (St Johnswort reacts badly with that class of drug), it's a powerful brain chemistry altering med (as all the SSRI and other anti-depressants are) and the potential for interaction and problems is high.
You may want to look into a couple other options. First, vitamin D... it's becoming obvious that our obesssion with "preventing skin cancer" in this country has contributed to a massive low-grade Vitamin D deficiency. Unless you spend an hour or so outdoors, *without sunscreen* at least 3-4 days a week, or take a good Vitamin D supplement, you are probably deficient. Depending on your insurance, you may want to get tested for your blood levels of D (PM Tweakette- IIRC, she has looked into a lot of this, and gotten good results for herself). Taking 2000 mg of D a day isn't as excessive as used to be thought. (don't do anything I say here without researching it yourself, please!!)
Also, remember that "depression" is basically a symptom. Yes, you can have "primary clinical depression", but I wonder how common that truly is. It can be secondary to many things- including external stress (which is what docs usually blame, but I suspect is actually a "cause" in a tiny percentage of cases), hormones (MUCH more common than you'd think!) and thyroid issues. Again, we've badly underestimated what is "normal" for thyroid numbers, from what I'm reading. I do wonder what is causing so many people to have thyroid problems these days!
If everything checks out otherwise, SAM-e may be a help.
One thing- not wanting to scare you, but- you need to be prepared for possible problems coming off the Wellbutrin. I haven't read much about that specific drug, but MANY of the newer anti-depressants are a LOT more physically "addictive" than most docs want to admit. That's not meant to be discouraging, but forwarned is forearmed- a lot of folks don't realize why they feel horrible as they start dropping the dose of these drugs, and the docs aren't a lot of help. They seem to think "well, if you don't feel good when you don't take it, obviously you need to keep taking it"... like that's a solution!
I had an idiot doc put me on Paxil once, and I swear, I had worse withdrawal symptoms from that than I did from a month on demerol in the hospital! You couldn't pay me enough to take that particular med, ever again.
Sorry it took me so long to reply to this- I was on my laptop computer for a few days until I could get a part for my main machine, and it's difficult to write long posts on that machine.
Summerthyme