4/30/08-5/6/08|Weekly Bird Flu Thread:Bird flu kills Indonesian, death toll now 108

JPD

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Bird flu kills Indonesian boy, death toll now 108

http://news.monstersandcritics.com/...d_flu_kills_Indonesian_boy_death_toll_now_108

Jakarta - A 3-year-old Indonesian boy has died from bird flu, raising the country's death toll from the H5N1 deadly disease to 108 - the world's highest, the health ministry said Wednesday.

The toddler, identified only as MS, from Central Java district of Wonogiri, first showed the flu-like symptoms of high fever and breathing difficulties on April 17.

On April 23, he was brought to the Muwardi Hospital in Solo, where he died on the same day, the ministry said in a statement.

Two laboratory tests came back positive for the H5N1 virus, and health investigators found the child had a history of contact with dead poultry.

The boy's death bring Indonesia's bird-flu death toll to 108 among the 133 diagnosed human cases of H5N1, the strain of bird flu that can be deadly in people. Both figures are the highest in the world.

Before the latest death in Indonesia, the World Health Organization had confirmed at least 240 deaths in 12 countries in Asia and Africa.

The most common way to contract the H5N1 virus is through human contact with infected fowl. Bird flu remains mainly an animal disease, but experts fear that the virus could mutate into a form that could spread easily from human to human, sparking a pandemic that could kill millions of people around the world.

Experts have warned that conditions in Indonesia such as a highly decentralized administration, under-resourced national veterinary services, lack of engagement with commercial poultry producers, insufficient financial and human resources and a difficulty in informing people of the dangers of the disease were hampering efforts to eradicate it.
 

JPD

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Akita inspects chicken farms over deadly avian flu virus

http://www.japantoday.com/category/...cts-chicken-farms-over-deadly-avian-flu-virus

AKITA —

Akita Prefecture on Wednesday began two-day on-site inspections into chicken farms near Lake Towada after the deadly H5N1 strain of avian influenza was detected in dead swans found in a lakeside town.

Through the inspections, livestock hygiene service center and municipal officials instruct the farmers about thorough sterilization as well as the use of bird nets and other measures to prevent wild birds from entering their farms. The deadly virus was detected in three of the four swans found dead or dying near the lake in the town of Kosaka in the prefecture April 21, a study by the National Institute of Animal Health showed Tuesday. The inspections cover about 42,000 birds at 15 farms within a radius of 30 kilometers of the location where the swans were found.
 

JPD

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More H5N1 Vaccine Resistance in Egypt

http://www.recombinomics.com/News/04290803/H5N1_Egypt_Vaccine_More.html

Recombinomics Commentary 21:49
April 29, 2008

Two H5N1 HA sequences from NAMRU-3 are being released at Genbank, A/chicken/Egypt/9402NAMRU-3/CLEVB213/2007 and A/chicken/Egypt/9403NAMRU-3/CLEVB214/2007. Both sequences are from isolates from Sharqiya and are closely related to the vaccine resistant sequences from Egypt and Israel.

The earlier isolates were from vaccinated flocks and had a large number of non-synonymous changes, suggesting the changes were in response to selection pressure linked to the vaccine(s). The changes included M230V, which is adjacent to the receptor binding domain. In addition to the changes in HA, the PB2 from the Israeli isolate had acquired a number of human polymorphisms, raising additional concerns.

These additional sequences from NAMRU-3 provide additional evidence for the emerging dominance of this strain, which will present vaccine problems due to the increased genetic diversity in Egypt and surrounding areas. Recent isolates from Saudi Arabia and Kuwait include clade 2.2.3 introductions to the region, and many of these polymorphisms have been appended onto the clade 2.2.1 genetic background in Egypt.

Recent migration through Egypt, which is located at the intersection of two major flyways will bring added diversity which will be appended onto the 2.2.1 genetic background via recombination.
 

JPD

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City to buy $1.5M worth of Tamiflu

http://www.nationalpost.com/todays_paper/story.html?id=478212

Toronto city council signed off yesterday on the purchase of $1.5-million worth of antiviral medication to treat up to 13,000 municipal employees in the case of a possible flu pandemic, despite budgetary constraints and amid lingering questions over who will be eligible to receive it and how.

Council was told Toronto is the only major Canadian city stockpiling its own supply of influenza-fighting drugs for its employees after learning from the SARS epidemic.

The decision follows the recommendation of Toronto's medical officer of health, who said Toronto must act now given the long lag time involved in acquiring Tamiflu, which is not a vaccine but one of the key drugs expected to be crucial in the event of an outbreak.

Under questioning from councillors as to the necessity of acting so urgently, David McKeown acknowledged he can't predict if or when a flu pandemic will strike.

"I believe it is a prudent measure to take for an event that is highly likely to occur," Dr. McKeown said, citing research that shows a major -- often lethal--flu virus sweeps the globe every 30 to 40 years.

Council also decided to spend $606,000 to properly store its drug supply in a warehouse.

In total, Toronto could spend up to $5-million stocking drugs to keep the city running in the event of a devastating flu virus.

Although a majority of council voted in favour of procuring the pharmaceuticals, questions swirled yesterday over who among Toronto's 24,000 municipal employees, plus thousands more police, firefighters and transit drivers, would receive the medication and how it would be dispensed.

Brian Ashton, the councillor for Scarborough Southwest, wondered how the city could spend so much on stockpiling a flu medication without knowing the strain that could eventually result in a pandemic or whether the antiviral will even be an effective treatment.

In the absence of a federal protocol on reacting to a flu outbreak and shifting opinions on how much of what particular drugs should be set aside, Denzil Minnan-Wong, the councillor for Don Valley East, questioned whether the city rushed into the decision.

Councillor Mike Del Grande, who represent Toronto Agincourt, said while it is good Toronto is taking a leadership role, he wondered if in its eagerness to act, the city was allowing the province and Ottawa to "off-load" an expensive responsibility on to local taxpayers.

But John Filion, the councillor for Willowdale, said after the experience of SARS, Toronto can't afford to bury its head in the sand. He presented two motions urging council to go even further by studying ways to afford the cost of developing a full stockpile for the city and hold discussions with the federal government.

"You have to plan for the worst and hope for the best," he said. "If we don't we are playing Russian roulette with the safety and security of the public. The gun is loaded."
 

JPD

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Bird flu knocking at Norway's door

http://www.aftenposten.no/english/article2397576.ece

Some 2,000 chickens and ducks had to be slaughtered in Fyn in Denmark on Tuesday after a routine test uncovered a strain of bird influenza – putting Norwegians on high alert.

Norway is keeping close contact with the Danish animal health authorities and continues to have a ban on fowl being allowed freedom to go outdoors (except under a roof and surrounded by netting), writes newspaper Aftenposten.

This is the first time in two years that the bird flu has been found in Denmark and the agricultural authorities have put an export ban in place for the time being.

Although it was dramatic for the farmers affected, the Danish veterinary authorities tried to keep things calm, pointing out that the bird flu strain found is not the most dangerous one -- the so-called H5N1-influensa, writes Aftenposten.

In fact, the farmers were allowed to stay on their farms, although the animals had to be killed.

In the end of December, there was an outbreak of the dangerous strain of bird flu in both Poland and Germany.

Meanwhile, anybody who finds a dead bird in Norway is encouraged to report it to the state food inspectorate Mattilsynet, at tel. 06040.
 

JPD

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Suspected Bird Flu Case Reported in Gyeongsang Region

http://english.chosun.com/w21data/html/news/200804/200804300011.html

Authorities have mounted an intensive examination for bird flu after about 100 chickens died from a new suspected outbreak of the disease at a farm in Ulsan in Gyeongsang region.

The disease is believed to have swept into the Gyeongsang provincial area after it hit North and South Jeolla provinces and South Chungcheong Province earlier this month, sparking concerns among quarantine authorities and poultry farmers over the nationwide spread of the disease.

According to the National Veterinary Research & Quarantine Service and the Ulsan city government on Tuesday, 104 chickens died at a poultry farm in Ulju County, Ulsan between April 22 to 28. Samples taken from the farm tested positive for avian influenza.

More examinations are underway to determine whether the disease is of a highly pathogenic virus. The quarantine agency plans to release the results of its examinations on Wednesday.

Ulju County banned the transport of poultry from farms within a 3 km radius of the suspected outbreak, quarantined the area immediately, and culled all chickens at the farm.

The Ministry of Food, Agriculture, Forestry and Fisheries said the latest outbreak brings the total number of reported bird flu cases to 54, of which 29 have tested positive for the disease. Five cases, including the latest suspected outbreak in Ulsan, are currently undergoing detailed testing.
 

JPD

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Bird flu spreads in S. Korea: ministry

http://www.straitstimes.com/Latest+News/Asia/STIStory_232991.html

SEOUL - SOUTH Korea on Thursday reported a new suspected bird flu outbreak, as officials confirmed two more cases of the disease despite a massive poultry cull.

Experts have travelled to the southern port city of Busan following a report of chickens dying suddenly, the agriculture ministry said.

It said two outbreaks reported earlier in North Kyeongsang province had been confirmed as the virulent H5N1 strain of the disease.

More than five million chickens and ducks have been slaughtered since the latest outbreak was reported on April 1, the ministry said.

South Korea reported seven cases of H5N1 infection between November 2006 and March last year, resulting in the temporary suspension of poultry exports to Japan, Hong Kong, Taiwan and elsewhere.

But last June, the World Organisation for Animal Health classified the country as free from the disease.

The H5N1 strain has killed more than 240 people worldwide since late 2003.

No South Koreans are known to have contracted the disease. -- AFP
 

JPD

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Swans, geese, ducks tested for bird flu virus in Akita, Aomori, Hokkaido

http://www.japantoday.com/category/...d-for-bird-flu-virus-in-akita-aomori-hokkaido

AOMORI —

The Environment Ministry began testing wild swans, geese and ducks against bird flu virus Thursday in Akita, Aomori and Hokkaido prefectures on the heels of the recent finding of the deadly H5N1 strain of virus in swans in Akita, ministry officials said.

Jointly with the governments of the three prefectures, the ministry will collect the feces of 20 to 100 sets of birds at inspection spots around lakes and rivers over the next several days and check if they are contaminated with any avian influenza, the officials said. Meanwhile, Akita and Aomori prefectures continued their own inspections on local chicken farms to see if they have taken necessary measures to prevent wild birds from entering their poultry houses and instructed the farmers about thorough sterilization methods as well as the use of bird nets and other measures against wild birds.
 

JPD

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H7N1 in Asymptomatic Domestic and Wild Waterfowl in Denmark

http://www.recombinomics.com/News/04300801/H7N1_Denmark.html

Recombinomics Commentary 21:49
April 29, 2008

The disease was detected a routine, annual check carried out by Danish veterinary authorities. The infected birds showed no outward clinical symptoms of the H7N1 flu virus, but laboratory tests revealed the birds had the disease, the spokesperson said. In all, 300 geese and 250 ducks at the farm will be killed, as well as around 1500 wild mallard.

The above comments describe the detection of H7N1 in asymptomatic waterfowl in Denmark (see satellite map) as described in the OIE report. This outbreak increases the number of recent H7 infections in the region. Last year England reported an H7N2 outbreak, which followed an H7N3 outbreak a year earlier. The largest outbreak was H7N7 in the Netherlands in 2003. All of these earlier outbreaks were associated with human infections. In 2003 there was one fatality and approximately 80 cullers were positive and had symptoms, which were primarily ocular. However, H7 antibody tests indicated the number of infected contacts was greater than 1000.

This high frequency of human infections has raised concerns that the number of undetected humans infected with H7 may be high. H7N2 patients were identified in the eastern United States, and H7N3 positive workers were identified during the 2004 H7N3 outbreak in British Columbia.

The current H7N1 outbreak in Denmark raises concerns of asymptomatic human infections in contact with the infected birds.

The release of sequence data from a New York resident infected with H7N2 in 2003 has raised additional concerns. The isolate had 3 avian genes (H7, N2, and NP), but it also had at least 4 human flu genes (PB1, PA, MP, NS – the PB2 sequence wasn’t released). The presence of the human genes in the avian H7N2 isolate supports a co-infection involving an avian H7N2 and a human H3N2 in 2003, based on the relatedness of the human genes to other human isolates. However, since the patient had no history of contact with birds, he may have been infected by another human infected with the H7N2 reassortant.

Mouse and ferret studies of the isolate created respiratory disease and the H7N2 levels in the nasal passages were higher than animals infected with human H3N2 raising additional concerns of efficient human to human transmission.

Since the patient recovered, the presence of an H7N2 recombinant raises concerns of additional undetected human cases. Similarly, the presents of an avian H and N raises concerns of additional human gene flu genes in birds which could then reassort or recombine with avian genes, including H5N1. H7 has been reported in other mammals, including seals and horses, raising concerns of additional genetic exchanges between avian and mammalian flu genes.
 

JPD

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H5N1 Migration From Japan Toward Alaska

http://www.recombinomics.com/News/05020801/H5N1_Japan_Alaska.html

Recombinomics Commentary 03:17
May 2, 2008

The recent confirmation of H5N1 in South Korea, Primorie, and Japan suggests H5N1 may be migrating toward the North American Aleutian Islands (see satellite map). At the beginning of April, South Korea reported H5N1 outbreaks at record levels. Although H5N1 has been confirmed in South Korea in three of the last five seasons, this season’s confirmations were the first in late spring, when birds were migrating to the north.

The northern migration of H5N1 was supported by they confirmation of H5N1 in Primorie, which was the first time Russian had reported H5N1 in the southeast region. The record outbreak in southwestern Korea subsequently spread to southeastern Korea, and North Korea went on bird flu alert.

Most recently, Japan reported dead swans in Akita on April 21. Three of the dead swans were H5N1 confirmed. Those deaths were followed by additional deaths on April 23 and 26 at the lake in Akita. This was followed by the detection of a dead swan on April 25 in Hokkaido, which has now been confirmed as bird flu positive, which will likely be confirmed as H5N1 positives.

Thus, the above series define a number of sites with H5N1 infected birds, including wild birds in Russia and Japan. These areas have not previously reported H5N1 in the late spring. These confirmations raise concerns that H5N1 is migrating north within the East-Asian / Australia flyway, which connects Japan and Russia to North America via the Aleutian Islands.

The latest confirmed case in Hokkaido is approximately 800 miles northeast of the outbreaks in Korea, and 800 miles from the western-most Aleutian Islands.

Japan has increased surveillance and has announced the activation of a pre-pandemic vaccine plan. Similarly, the United States has announced the purchase of vaccine directed against clade 2.2 H5N1 isolated from a bar headed goose.

The latest developments point toward an H5N1 migration into North America in the upcoming weeks.

Sequence data on the isolates from South Korea, Japan, and Russia would be useful.
 

JPD

Inactive
Dead swan in Hokkaido tests positive for bird flu

http://search.japantimes.co.jp/cgi-bin/nn20080502b1.html

A dead swan found in the Notsuke Peninsula in eastern Hokkaido has tested positive for bird flu virus, the Environment Ministry said Thursday.

Hokkaido University will test it further to determine if the virus is highly pathogenic. The swan was found April 24.

Earlier Thursday, the ministry began testing wild swans, geese and ducks for bird flu in Hokkaido, Akita and Aomori prefectures. The action follows the discovery of the deadly H5N1 strain of avian influenza in three of four swans found dead or dying near Lake Towada in Akita Prefecture on April 21.

The ministry plans to collect droppings from 20 to 100 birds at test spots around lakes and rivers for several days to see if they contain avian influenza.
 

JPD

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WHO denies avian flu warning for Beijing Olympics

http://www.ctv.ca/servlet/ArticleNews/story/CTVNews/20080501/who_china_080501/20080501?hub=Health

GENEVA -- The World Health Organization denies it is recommending that visitors to China for this summer's Olympic Games should pack an antiviral drug to protect themselves against avian flu.

The denial comes in the wake of a report Monday by the Italian news agency Ansa, which said WHO is warning tourists going to Beijing for the August sports event to arm themselves with the drug Tamiflu "in case of exposure to the disease virus.''

The Ansa story quotes Walter Pasini, director of the WHO Collaborative Centre of Medicine for Tourism in Rimini, Italy.

But WHO spokesman Gregory Hartl said Wednesday that Pasini does not work for the international agency itself and the report quoting him has "set off alarm bells'' because it is erroneous.

"We would categorically deny that WHO's ever made any kind of recommendation to this effect or that there would be any need or justification ... in any context, including going to the Olympics in Beijing,'' Hartl said.

Pasini could not be reached for comment late Wednesday.

The WHO's website shows there have been 30 cases of avian flu, also known as H5N1, reported in all of China since 2003 -- three of them so far this year -- and 20 of them ended in death.

The hardest-hit country has been Indonesia, with 133 cases, including 108 deaths. Worldwide, there have been 382 cases, with 241 deaths since 2003, the website said.
 

JPD

Inactive
H5N1 Spread in Eastern South Korea

http://www.recombinomics.com/News/05010801/H5N1_Korea_East.html

Recombinomics Commentary 13:30
May 1, 2008

The government said Wednesday that it will temporarily halt the sale of ducks and chickens in traditional open markets to prevent the further spread of bird flu in the country.

A suspected bird flu case has been reported in Busan while two more outbreaks in the southeastern region of South Korea have been confirmed as virulent strains of the avian influenza, the government said Thursday.

The above comments describe the record spread of H5N1 in South Korea, including new outbreaks in the southeast (see satellite map). Over 6 million birds have been culled and the sale of birds at open markets has been suspended.

The outbreaks are likely linked to wild bird migration. Whooper swans have tested positive in Japan this week The affected regions in southern Korea are under a whooper swan flyway from Mongolia. Last season, the H5N1 in South Korea and presumably Japan, were closely related to clade 2.2 H5N1 from a summer of 2006 outbreak at the largest lake in Mongolia, Uvs Lake. The clade 2.2.3 strain linked to Uvs Lake has also spread throughout Europe and the Middle East.

Japan has recently announced the activation of a pre-pandemic vaccine plan that begins with first responders and may include 10-20 million citizens. Similarly, the United States has ordered up to 38.5 million doses of a vaccine targeting clade 2.2 isolate from a bar-headed goose. Clade 2.2 is linked to migratory birds and reported in over 50 countries west of China, including those in Europe, the Middle East, and Africa.
 

JPD

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Bird flu breaks out in one more southern province

http://english.vietnamnet.vn/social/2008/05/781086/

VietNamNet Bridge – Bird flu has been discovered in the southern province of Vinh Long, killing nearly 400 chickens of a farmer family in Xuan Hiep commune, Tra On district, reported the local veterinary agency.

According to Labourer Newspaper, chickens died on a massive scale on April 26. On April 28, the veterinary agency announced its test results, which showed that the chickens had died of bird flu. None of the chickens were vaccinated.

Vietnam currently has three provinces with this disease, Can Tho and Vinh Long in the south and Son La in the north.

Meanwhile, Youth Newspaper reported that foot-and-mouth disease in cattle is now in the two central provinces of Nghe An and Ha Tinh.

Blue ear disease in pigs continues to develop and it currently exists in ten provinces, including Ha Tinh, Quang Nam, Thanh Hoa, Nghe An, Thua Thien-Hue in the central region, Thai Binh, Thai Nguyen, Nam Dinh and Ninh Binh in the north.
 

JPD

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Swine, Avian Flu Genes in Same Virus

http://www.thepigsite.com/swinenews/17809/swine-avian-flu-genes-in-same-virus

US - An unknown pathogen isolated from infected pigs at two midwestern swine production facilities in 2006 has proved to be a new strain of H2 influenza virus.

USDA ARS
USDA

The pathogen is similar to the one that caused the 1957 flu pandemic, says the USDA Agricutural Research Service.

Reporting the findings in the May June issue of Agricultural Research magazine, it says the virus was first identified by a University of Minnesota veterinary diagnostician - and it proved to have a startling new twist because it contained genes of both swine and avian influenza viruses.

Molecular studies indicate that the mystery pig pathogen is actually an H2N3 influenza virus closely related to an H2N3 strain found in mallard ducks—being seen for the first time in mammals.

Both swine facilities used pond water frequented by migrating waterfowl.

In the newly isolated swine H2N3, the avian H2 and N3 gene segments mixed with gene segments from common swine influenza viruses, giving it the ability to infect swine—as well as mice and ferrets

. This suggests the need for continued monitoring of both swine and livestock workers for H2-subtype viruses and other influenza strains.
 

JPD

Inactive
H5N1 Spread in Korea Linked to Northeastern Migration?

http://www.recombinomics.com/News/05030801/H5N1_Korea_Migration_NE.html

Recombinomics Commentary 10:54
May 3, 2008

Bird flu outbreaks have spread to six of South Korea's nine provinces despite a massive cull which saw the slaughter of more than five million chickens and ducks last month, officials said Saturday.

An outbreak reported Wednesday at a farm around 300 kilometers (187 miles) southeast of Seoul was confirmed after blood tests as the virulent H5N1 strain of the disease, the agriculture ministry said.

It raised to 23 the total number of outbreaks reported across six provinces of South Korea.

Meanwhile quarantine authorities denied allegations they had covered up an outbreak of avian influenza in the province of North Gyeongsang last month.

Responding to a television report, they said they had been cautious of the results of preliminary tests on poultry at Yeongcheon City, but final results confirmed the outbreak.

The above comments confirm that H5N1 has spread throughout South Korea (see satellite map) and the disclosure of the spread has been delayed by the withholding of test results. This approach is similar to the control efforts by India.

South Korea has defined 11 outbreaks in OIE reports, which have not been filed since the middle of last month. The most recent report, and associated press releases, were careful to draw distinctions between highly pathogenic H5 and highly pathogenic H5N1, when in fact the only difference is the number of confirmatory tests that have been announced. Last season the H5N1 in south Korea was the Uvs Lake strain of H5N1, which is within a sub-clade (2.2.3) of clade 2.2. It is likely that this seasons outbreaks will be related, so the H5N1 will have the HA cleavage site GERRRKKR. Sequencing of the cleavage site is one of the first tests on influenza A positive samples. The series of test are confirmatory in nature. Samples with GERRRKKR will be H5 which will be highly pathogenic H5, which will be highly pathogenic H5N1, which will be clade 2.2 H5N1, which will be clade 2.2.3, which will be the Uvs Lake strain of clade 2.2.3. Thus, the distinction between highly pathogenic H5 and highly pathogenic H5N1 is only administrative, and dependent on the extent of completing a series of confirmatory tests.

These distinctions have been used to delay confirmation that the soldier infected with highly pathogenic H5 is infected with highly pathogenic H5N1.

However, these delays in testing can lead to delays in actions, which leads to an increase in spread. More than 6 million birds have been culled and live market trading has been suspended, but new outbreaks are confirmed as test results are announced.

This record break outbreak in South Korea has been followed by detection of H5N1 in northeastern Japan and southeastern Russia, which may be signaling migration of H5N1 to Alaska, which is likely seeded by the massive outbreaks in South Korea.

Release of H5N1 sequences from Korea, Japan, and Russia would be useful.
 

JPD

Inactive
Bird flu spreading in S. Korea : officials

http://www.straitstimes.com/Latest+News/Asia/STIStory_233612.html

SEOUL - BIRD flu outbreaks have spread to six of South Korea's nine provinces despite a massive cull which saw the slaughter of more than five million chickens and ducks last month, officials said on Saturday.

An outbreak reported Wednesday at a farm around 300 kilometres southeast of Seoul was confirmed after blood tests as the virulent H5N1 strain of the disease, the agriculture ministry said.

It raised to 23 the total number of outbreaks reported across six provinces of South Korea.

Only the northeastern province of Gangweon, North Chungcheong in the centre and the southern island of Jeju have been unaffected so far, according to the ministry.

Meanwhile, quarantine authorities denied allegations they had covered up an outbreak of avian influenza in the province of North Gyeongsang last month.

Responding to a television report, they said they had been cautious of the results of preliminary tests on poultry at Yeongcheon City, but final results confirmed the outbreak.

South Korea reported seven cases of H5N1 infection cases between November 2006 and March last year, resulting in temporary suspension of poultry exports to Japan, Hong Kong, Taiwan and elsewhere.

Last June, however, the World Organisation for Animal Health classified the country as free from the disease.

The H5N1 strain has killed more than 240 people worldwide since late 2003.

No South Koreans are known to have contracted the disease. -- AFP
 

JPD

Inactive
H5N1 Surveillance Concerns in Japan and Alaska

http://www.recombinomics.com/News/05020803/H5N1_Alaska_Japan.html

Recombinomics Commentary 22:24
May 2, 2008

The detection of H5N1 in southeastern Russia and northeastern Japan has raised concerns of H5N1 migration into new regions. In the past H5N1 in central or eastern Russia was limited to southern Siberia near Chany Lake in Novosibirsk, or Uvs Lake in Mongolia. Although low path H5 has been detected in southeastern Russia near Lake Khanka in Russia or Xingkai in China, the first confirmed case of H5N1 was reported last month. Similarly, H5N1 in Japan was limited to central and southern regions. The confirmed H5N1 in Akita and suspected H5N1 in Hokkaido represent new areas and raise concerns that H5N1 is expanding its geographical reach into North America via the Aleutian Island (see satellite map).

There have not been any confirmed H5N1 outbreaks in North America, although the circumstances surrounding the H5 PCR positive dead gosling on Prince Edward Island suggest H5N1 may already be circulating in North America, but hasn’t been confirmed. The testing protocols in North American surveillance continue to raise concerns because testing of fecal samples or cloacal swabs is not sensitive, especially for clade 2.2, which is the H5N1 circulating in migratory birds.

The outbreaks in southeastern Russia and northwestern Japan are the closest confirmed H5N1 cases to North America. The case in Hokkaido is approximately 800 miles from the Aleutian Islands, which has focused attention of surveillance in Alaska. The public protocols indicate that testing will involve fecal samples and cloacal swabs, even though these approaches are likely to generate false negatives. Similarly, Japan plans to increase testing of fecal samples to 20-100 per site, which is also unlikely to detect H5N1.

The approaches are curious because the lack of sensitivity is well known. The failure of these approaches to detect H5N1 in live birds near dead and dying H5N1 positive waterfowl raised serious concerns over these approaches, and multiple studies have demonstrated that pharyngeal and throat swabs are more sensitive than cloacal swabs. Since the studies in Alaska include collection of cloacal swabs, the rationale behind not also taking pharyngeal or tracheal swabs is unclear.

Collection of more pharyngeal or tracheal swabs would be useful.
 

JPD

Inactive
More bird flu cases reported in RoK

http://www.vnanet.vn/Home/EN/tabid/119/itemid/247641/Default.aspx

Hanoi (VNA) – The H5N1 strain of bird flu have killed five birds at a private home in Daegu, the Republic of Korea (RoK).

The five chickens were purchased at an open-air market in the industrial city which is 302 kilometres southeast of Seoul , the RoK’s Yonhap news agency quoted officials from the National Veterinary Research and Quarantine Service (NVRQS) as saying on May 3.

The officials are tracking where the birds came from, Yonhap said.

In order to prevent further spreading of the avian influenza, 260 chickens raised in three small-scale farms within a three kilometre radius of the home have been culled and buried.

Earlier in the week, the RoK government said it would ban the sale of all poultry sold at traditional markets that are open at regular intervals. The measures were taken after experts said the recent outbreaks in the southeastern Gyeongsang region were caused by people buying birds from such markets, according to Yonhap. –Enditem
 

JPD

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Thailand extends bird flu monitoring for two months

http://www.vnanet.vn/Home/EN/tabid/119/itemid/247642/Default.aspx

Bangkok (VNA) – Thailand has decided to extend the bird-flu monitoring period for another two months, retroactive to May 1, local media reported.

The Livestock Development Department has asked provinces, which are believed to be risk-prone to the bird flu virus, to organise a week-long campaign on monitoring and destroying avian influenza and other varieties of influenza between May 1 and June 30, the Thai news agency (TNA) cited Sakchai Sriboonsue, Director General of the department as saying on May 3.

The decision was made despite an absence of any new bird flu cases during a 90-day observation, which ended April 25, the official said, adding that the extension of the monitoring period was made due to changes in weather in a number of provinces, which may yet lead to further outbreaks.

Earlier on May 2, Thailand declared itself free of bird flu after no outbreaks of the deadly virus were reported over the past 90 days. –Enditem
 

JPD

Inactive
Triage plan details whom to let die during a pandemic
Treatment blueprint gives severely hurt, elderly lower priority

http://www.sfgate.com/cgi-bin/article.cgi?file=/c/a/2008/05/05/MNM210GNVM.DTL

Doctors know some patients needing lifesaving care won't get it in a flu pandemic or other disaster. The gut-wrenching dilemma will be deciding whom to let die.

Now, an influential group of physicians has drafted a grimly specific list of recommendations for which patients wouldn't be treated. They include the very elderly, seriously hurt trauma victims, severely burned patients and those with severe dementia.

The suggested list was compiled by a task force whose members come from prestigious universities, medical groups, the military and government agencies. They include the Department of Homeland Security, the Centers for Disease Control and Prevention, and the Department of Health and Human Services.

The proposed guidelines are designed to be a blueprint for hospitals "so that everybody will be thinking in the same way" when pandemic flu or another widespread health care disaster hits, said Dr. Asha Devereaux, a critical care specialist in San Diego and lead writer of the task force report.

The idea is to try to make sure that scarce resources - including ventilators, medicine and doctors and nurses - are used in a uniform, objective way, task force members said.

Their recommendations appear in a report published today in the May edition of Chest, the medical journal of the American College of Chest Physicians.

"If a mass casualty critical care event were to occur tomorrow, many people with clinical conditions that are survivable under usual health care system conditions may have to forgo life-sustaining interventions owing to deficiencies in supply or staffing," the report states.

To prepare, hospitals should designate a triage team with the Godlike duty of deciding who will and who won't get lifesaving care, the task force wrote. Those out of luck are the people at high risk of death and a slim chance of long-term survival. But the recommendations get much more specific and include:

-- People older than 85.

-- Those with severe trauma, which could include critical injuries from car crashes and shootings.

-- Severely burned patients older than 60.

-- Those with severe mental impairment, which could include advanced Alzheimer's disease.

-- Those with a severe chronic disease, such as advanced heart failure, lung disease or poorly controlled diabetes.

Dr. Kevin Yeskey, director of the preparedness and emergency operations office at the Department of Health and Human Services, was on the task force. He said the report will be among many the agency reviews as part of preparedness efforts.

Public health law expert Lawrence Gostin of Georgetown University called the report an important initiative but also "a political minefield and a legal minefield." The recommendations would probably violate federal laws against age discrimination and disability discrimination, said Gostin, who was not on the task force.

If followed, such rules could exclude care for the poorest, most disadvantaged citizens who suffer disproportionately from chronic disease and disability, he said. While health care rationing will be necessary in a mass disaster, "there are some real ethical concerns here."

James Bentley, a senior vice president at American Hospital Association, said the report will give guidance to hospitals in shaping their own preparedness plans, even if they don't follow all the suggestions. He said the proposals resemble a battlefield approach in which limited health care resources are reserved for those most likely to survive.

While the notion of rationing health care is unpleasant, the report could help the public understand that it will be necessary, Bentley said.

Devereaux said compiling the list "was emotionally difficult for everyone." That's partly because members believe it's just a matter of time before such a health care disaster hits, she said.

"You never know," Devereaux said. "SARS took a lot of folks by surprise. We didn't even know it existed."
 

JPD

Inactive
N.Korea inoculates poultry against bird flu
following outbreak in S.Korea

http://www.straitstimes.com/Latest+News/Asia/STIStory_234198.html

SEOUL (South Korea) - NORTH Korea said on Monday it has inoculated poultry against bird flu to prevent the spread of the virus from neighboring South Korea.

The North's Korean Central News Agency quoted quarantine official Ri Kyong Gun as saying all poultry in provinces near the border with the South have received emergency vaccinations, citing a bird flu outbreak in southern South Korea.

South Korea has slaughtered about 6.5 million chickens, ducks and other poultry since early last month when bird flu broke out there for the first time in more than a year.

Mr Ri was quoted as saying the North has also set up 1,600 observation posts along the east and west coasts to monitor the movement of migratory birds - which he said are a key way the virus spreads.

The North has intensified its quarantine efforts on poultry farms and ordered farmers to keep their poultry in pens to stop them from coming into contact with migratory birds, it said.

The North banned South Korean poultry and eggs from a joint South-North industrial zone late last month, according to the Kaesong Industrial District Management Committee.

South Korea had been sending 85,000 tonnes of chicken and 127,000 eggs to the complex in the North Korean border city of Kaesong every month for food for workers there, according to the South Korean Unification Ministry.

Bird flu hit North Korea in 2005, leading to the killing of about 210,000 birds, but no new cases have been reported since then. -- AP
 

JPD

Inactive
H5N1 bird flu found in swan in Japan

http://www.straitstimes.com/Latest+News/Asia/STIStory_234186.html

TOKYO - THE deadly H5N1 bird flu virus was found in a wild swan in northern Japan, but no poultry in the area have been found to be sickened with the disease, a health official said on Monday.

The dead swan was found on April 24 on the northern island of Hokkaido, said a local official who spoke on condition of anonymity because he was not authorised to speak to the press.

Following the discovery, health authorities began inspecting five chicken farms within a 30-kilometre radius of where the infected swan was found.

No reports of sick poultry have been discovered so far on the five farms, which raise about 9,500 chickens in total, the official said.

H5N1 was also confirmed in dead swans in northeastern Akita prefecture (state) on April 29.

The virus remains hard for people to catch, but scientists worry it could mutate into a form that spreads more easily between humans, with the potential to kill millions worldwide.

At least 240 people have died from bird flu since 2003, according to the World Health Organisation.

Most human cases so far have been linked to contact with infected poultry.

No human cases of the bird flu virus have been reported in Japan. -- AP
 

JPD

Inactive
Bird flu outbreak reaches RoK's capital

http://www.vnanet.vn/Home/EN/tabid/119/itemid/247946/Default.aspx

Hanoi (VNA) - The bird flu outbreak that has swept the Republic of Korea (RoK) reached the capital Seoul on May 6, prompting quarantine officials to decontaminate and limit access to a nearby children's park and open air market.

Yonhap news agency quoted RoK’s Ministry for Food, Agriculture, Forestry and Fisheries as saying that tests conducted on four birds that began dying off in late April at a bird vivarium in eastern Seoul showed they were contaminated with the H5 avian influenza virus.

The ministry said all birds in the vivarium have been culled and buried as a precautionary measure, while detailed tests to determine if the deaths were caused by a virulent strain of the bird flu will be made known later.

Most of the initial bird flu cases reported this year were centered in the Jeolla region, according to Yonhap news agency.-Enditem
 

JPD

Inactive
Another Hokkaido H5N1 Confimation Raises Migration Concerns

http://www.recombinomics.com/News/05050802/H5N1_Hokkaido_2.html

Recombinomics Commentary 17:48
May 5, 2008

The deadly H5N1 strain of avian influenza has been detected in a dead swan found April 24 on the Notsuke Peninsula in eastern Hokkaido, the Environment Ministry said Monday.

Another dead swan found Monday beside Lake Saroma in eastern Hokkaido was also found to be infected with bird flu virus through a preliminary examination, the Hokkaido prefectural government said.

The above comments describe a second H5N1 positive swan in Hokkaido (see satellite map). The latest outbreaks in Hokkaido and Akita are markedly north of prior outbreaks. A detailed report on the earlier outbreaks includes phylogenetic trees that include last years isolates (listed below), and includes migratory routes between Japan and Asia based on satellite tracking. These data confirm that the H5N1 in Japan in early 2007 was closely related to the H5N1 in South Korea in late 2006, which was the Uvs Lake strain of clade 2.2. The migration data link swans in northern Japan to areas due north in northeastern Siberia. Movement of H5N1 to northeastern Siberia would set the stage for transfer to species in Alaska, followed by the migration of H5N1 south into Canada and the United States.

The confirmation of H5N1 in northern Japan as well as southeastern Russia suggest that H5N1 is expanding into new areas to set the stage for a migration into North America. However, the current surveillance approaches, which are largely directed toward cloacal swabs and fecal collections which are not likely to detect the H5N1, which is highest in tracheal swabs or organs from hunter killed birds.

A/Ck/Miyazaki/S749/07
A/Ck/Miyazaki/H358/07
A/Ck/Miyazaki/K11/07
A/Mountain hawk-eagle/Kumamito/1/07
A/Ck/Okatama/T6/07
 

JPD

Inactive
H5N1 Spread to Children's Zoos in Seoul Korea

http://www.recombinomics.com/News/05060801/H5N1_Seoul.html

Recombinomics Commentary 08:29
May 6, 2008

The Ministry for Food, Agriculture, Forestry and Fisheries said tests conducted on four birds that started dying off from late April showed they were contaminated with the H5 avian influenza virus.

The bird vivarium located at the Gwangjin ward office in eastern Seoul raised 57 chickens, ducks, pheasants and turkeys. The outbreak marks the first time that the avian influenza has hit Seoul since quarantine officials received reports of wholescale bird deaths on April 1.

As a precaution, officials also slaughtered 63 birds at Children's Grand Park, a major amusement park about 1.2 kilometers (less than a mile) from the outbreak site, and 191 birds at Seoul Grand Park, another theme park south of the capital.

The above comments describe the spread of H5 to Seoul (see satellite map). The death of the birds indicates the H5 will be confirmed as H5N1. Thus far all H5 infections in Korea this year have been H5N1. There have been no reports of low path H5. Similarly the H5 detected in northern Japan have also been H5N1, further supporting the likelihood that H5N1 has reached the South Korean capital.

A recent report on the 2007 outbreaks in Japan demonstrates that the H5N1 in Japan in early 2007 is closely related to the H5N1 in South Korea in late 2006, which was the Uvs Lake strain.

Therefore, it is likely that the H5N1 in South Korea and Japan this season is also closely related. The record outbreaks in South Korea likely played a role in Japan's decision to implement a pre-pandemic vaccination plan.

This decision was further support by reports of H5 in a soldier in Korea. Although South Korea has still not official confirmed that the H5 in the soldiers was H5N1, the lack of any reports of low path H5 in South Korea or Japan, coupled with the linkage of the soldier to culling operations on H5N1 leaves little doubt that the H5 infection in South Korea represents the first confirmed human case in South Korea or Japan.
 
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