10/6/07-10/12/07|Weekly Bird Flu Thread:H5N1 mutates, more infectious to humans

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HEALTH - 10/6/07-10/12/07|Weekly Bird Flu Thread:Bird flu virus mutates into a strain more infectious to humans

Link to Last Weeks Thread:

HEALTH - 9/29/07-10/5/07|Weekly Bird Flu Thread:Bird flu virus can pass from mother to fetus

http://www.timebomb2000.com/vb/showthread.php?t=259144

Johns Hopkins on influenza:

http://www.iom.edu/Object.File/Master/33/450/Rashid Chotani.pdf

National Avian Influenza Surveillance Information:

http://wildlifedisease.nbii.gov/ai/

CDC

http://www.cdc.gov/flu/avian/index.htm

WHO

http://www.who.int/csr/disease/avian_influenza/en/index.html

CIDRAP

http://www.cidrap.umn.edu/

Official U.S. Government Web site

http://www.pandemicflu.gov/

FAO

http://www.fao.org/ag/againfo/subjects/en/health/diseases-cards/special_avian.html

Public Health Agency of Canada

http://www.phac-aspc.gc.ca/influenza/avian_qa_e.html

European Union

http://ec.europa.eu/dgs/health_consumer/dyna/influenza/country_en.htm

The World Bank

http://web.worldbank.org/WBSITE/EXT...68427~piPK:64168435~theSitePK:1793593,00.html
 

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Bird flu virus mutates into a strain more infectious to humans

http://news.independent.co.uk/health/article3033350.ece

By Jeremy Laurance, Health Editor
Published: 06 October 2007

The bird flu virus H5N1 has mutated into a form that makes it more infectious to humans, increasing the risk of a human pandemic, researchers have found.

The changes, which only affect the virus circulating in Europe and Africa, are worrying although they have not yet transformed it into a pandemic strain, Yoshihiro Kawaoka, of the University of Wisconsin-Madison, who led the research, said.

The outbreak of avian influenza caused by the lethal virus H5N1 began in Asia in 2003 and spread around the world, leading to the slaughter of hundreds of millions of birds.

More than 30 countries have reported outbreaks in the last year, mostly in wild birds such as swans. The virus has infected 329 people since 2003, of whom 201 have died, according to the World Health Organisation.

Governments have responded to the threat by stockpiling millions of doses of the anti-flu drug, Tamiflu, and preparing emergency plans for dealing with a pandemic.

In the UK, the disease broke out on a Bernard Matthews turkey farm in Suffolk and more than 100,000 poultry were culled after the virus was apparently imported from Hungary. But there have been no human cases in the UK or Europe.

Writing in the Public Library of Science journal, PLoS Pathogens, Dr Kawaoka and colleagues say recent samples of virus taken from birds in Europe and Africa all carry the mutation, which makes the virus more likely to grow in the nose and throat of humans.

"I don't like to scare the public, because they cannot do very much," Dr Kawaoka tolds the Reuters news agency. "But at the same time it is important to the scientific community to understand what is happening."

Humans have a lower body temperature than birds and the avian virus finds it difficult to grow in the cooler conditions of the human throat. The mutated virus is better adapted to these cooler conditions, making transmission more likely.

"The viruses circulating in Europe and Africa all have this mutation," Dr Kawaoka said. "So they are the ones that are closer to human-like flu."

All flu viruses are evolving constantly and other mutations were necessary to convert H5N1 avian flu into a human pandemic strain, he said.

European specialists are divided about the likelihood of a human pandemic caused by the H5N1 virus. Sceptics say that as the virus has been circulating for four years, and if it were going to mutate into a pandemic strain it would have done so by now.

Those of a gloomier cast of mind say the risk is still high that it could evolve into a lethal strain that would kill on the scale of the 1914 pandemic when an estimated 40 million people died.

Professor Angus Nicoll, the flu co-ordinator at the European Centre for Disease Prevention and Control in Stockholm, said: "Agnostics like me are in the middle. My view is that we have to prepare for a pandemic even though we haven't seen any changes in the behaviour of the virus in the field."

Scientists are agreed that, even if the H5N1 strain does not cause a human pandemic, it is likely that a future strain will do so. There were three pandemics in the last century – in 1918, 1957 and 1968 – and more are expected.

Professor Nicoll said countries were having to decide whether to buy newly developed vaccines against H5N1. Some such as Finland and Switzerland, had placed large orders, but that involved gambling on a human pandemic caused by the H5N1 strain happening in the next few years. Other countries, including the UK, had ordered smaller amounts for certain groups in the population. "It is a difficult choice," Professor Nicoll said.
 

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E627K Increases H5N1 Replication at Lower Temperatures

http://www.recombinomics.com/News/10050702/H5N1_E627K_Temp.html

Recombinomics Commentary
October 5, 2007

Birds usually have a body temperature of 106 degrees F, and humans are 98.6 degrees F usually. The human nose and throat, where flu viruses usually enter, is usually around 91.4 degrees F.

"So usually the bird flu doesn't grow well in the nose or throat of humans," Kawaoka said. This particular mutation allows H5N1 to live well in the cooler temperatures of the human upper respiratory tract.

H5N1 caused its first mass die-off among wild waterfowl in 2005 at Qinghai Lake in central China, where hundreds of thousands of migratory birds congregate.

That strain of the virus was carried across Asia to Africa and Europe by migrating birds. Its descendants carry the mutation, Kawaoka said.

"So the viruses circulating in Europe and Africa, they all have this mutation. So they are the ones that are closer to human-like flu," Kawaoka said.

Luckily, they do not carry other mutations, he said.

The above comments on the paper describing PB2 E627K replication in experimental mice and cells highlight the effect of the change on the ability of the Qinghai strain to replicate at lower temperatures.

The detection of E627K in dead wild birds at Qinghai Lake in May, 2005 signaled a major change in the global spread of H5N1. At the time “Asian” H5N1 had not been reported in any country west of China. The massive die-off at Qinghai Lake signaled the movement of H5N1 in long range migratory birds and the strain of a major geographical expansion.

The data on the temperature dependence of E627K also explains why many surveillance programs fail to detect Qinghai H5N1 in live wild birds, including locations where H5N1 is readily detected in dead or dying wild birds. The body temperature of live wild birds keeps the levels of the virus low, below the detection levels of these assays. Dead and dying birds have a lower body temperature, allowing levels of the virus to rise.

Although the effect of E627K on viral replication has been know since 2001, this fact has been ignored in the surveillance programs that focus on live birds. Instead of measuring H5N1 antibody levels, which are more stable and reliable, these groups test thousands of birds and then use the false negatives to issue assurances and denials of the transport and transmission of H5N1 by wild birds.

Consequently, the alarming expansion of Qinghai H5N1 has largely happened below the radar of these surveillance, which remains a cause for concern, as have changes in the receptor binding domain in Qinghai isolates from fatal human cases, including V223I, S227N, and M230I.
 

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Risk of a bird flu outbreak remains on high alert

http://english.vietnamnet.vn/social/2007/10/748067/

VietNamNet Bridge - Highly pathogenic avian influenza (HPAI) is temporarily under control in Viet Nam, however the risk of a bird flu outbreak is still on high alert.

This was announced by the Director of the Preventive Health Department, Nguyen Huy Nga at a conference yesterday in Hanoi.

The focus of this conference was the modification and supplementation of plans made to protect humans from avian influenza. Those in attendance included the Ministry of Health and the US Centers for Disease Control and Prevention (CDC).

The development of avian flu in humans is occuring in a complex manner. Transmitted from infected poultry to humans, the disease, known as the H5N1 virus, is able to mutate or change. These mutations may affect its ability to spread by human-to-human transmission, Director Nga added.

The World Health Organization (WHO) also warned that a great influenza pandemic of type A H5N1 could kill from one to more than 40 million people worldwide.

According to the Ministry of Health, relevant departments, organizations and individuals have to join nation-wide campaigns to curb the spread of bird flu. To halt the spread of bird flu to humans, the Government needs to put in place the structural framework and provide education about bird flu transmission and prevention to all farms and households.

The ministry will also establish 15 influenza management offices in the North and South. These offices will collect and study samples for monitoring purposes, as well as provide guidance and quarantine control to bird flu affected areas.

The country has controlled the type A H5N1 influenza pandemic in humans for 17 months. Since May 10th 2007, there have been 7 reported cases of Type A H5N1 in five northern provinces, among them 4 have been fatal.
 

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'Bouncy castle mortuaries' planned for bird flu dead

http://news.scotsman.com/scotland.cfm?id=1601372007

KATE FOSTER

SCOTTISH Government officials are preparing to buy hundreds of inflatable body storage tents in preparation for mass deaths in a flu pandemic.

Documents obtained under Freedom of Information laws reveal officials and police have been in talks with a major manufacturer of the tents, known as "bouncy castle mortuaries", in an attempt to cope with the death of 64,000 Scots from the virus.

The documents also reveal funeral services would have to be cut short because of sheer demand. An investigation of mortuaries across the country has revealed a shortage of body storage space if a pandemic should occur, with a maximum of 2,513 spaces.

Experts say Scotland's crematoriums could not cope with the demand of disposing of thousands of dead and temporary body storage would be essential.

Health experts predict a global epidemic of a deadly new strain of bird flu in humans will strike at some point in the future.

The current strain of H5N1 avian influenza has killed more than 200 people. So far it is limited to a handful of countries including Indonesia and Vietnam but there are fears it could spread quickly across the globe if it is not contained.

In June Scottish Government officials met representatives from a firm which manufactures inflatable tents for body storage.

E-mail exchanges and letters reveal officials and police are impressed with a mobile "body storage system" made by Airegroup, for use in disasters. It has been used by the US military and uses a generator to keep bodies at a cool temperature so that they do not decompose.

Police and local authorities across Scotland have now been told to consider purchasing the equipment or consider taking part in trials of new prototypes so that they could purchase the equipment at a cheaper rate. The units cost around £10,000 and can store up to 50 bodies.

Trials could involve storing dead animals from veterinary hospitals.

One e-mail, from Alastair MacDonald, policy analyst at the Scottish Government's Civil Contingencies Unit, to Derek Robertson at the Scottish Police Services Authority in June, discusses the tent. It states: "The product is very much a concept just now. We will be asked to assist in testing the prototypes then will be offered a discount on sales when in production."

Officials are anxious to avoid burying Scots in mass burial sites because of "severe distress" it would cause.

Another Scottish Government document states that relatives may have to hold shorter funerals because of the "rapid disposal of the dead".

A Scottish Government spokeswoman said the work had been prepared so that local Strategic Coordinating Groups could decide how to plan for a pandemic.
 

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How do you plan for a nightmare?

http://www.buffalonews.com/145/story/178966.html

Businesses ponder how to operate in case of bird flu pandemic
By Jonathan Epstein NEWS BUSINESS REPORTER
Updated: 10/07/07 7:37 AM

When Patricia Buckley came to work on Monday, her company was in crisis mode. About 90 people were out sick or caring for family members — nearly half of the work force — so she and her team mobilized fast.

Just two weeks earlier, a global bird flu pandemic had struck several U.S. cities and swept quickly across the country, overwhelming emergency rooms.

Nationwide, half of U.S. workers were ill or otherwise not at work. Full distribution of a vaccine was three months away.

Mail delivery was down to once a week. Two-hour rolling blackouts and brownouts were common as demand surged and repairs could not be made.

The supply of goods was falling, and some businesses had either closed or were being run from homes. And the crisis was hammering Buckley’s company, Merchants Mutual Insurance Co., along with its customers and independent agents.

But Buckley couldn’t just hide from the illness at home. As part of Merchants’ disaster response team, the director of information technology operations had to make sure the company still had enough staff to function, run its operations and meet its customers’ needs — including handling telephone calls and insurance claims.

“If it gets a lot worse, it’s going to get a lot worse throughout the entire United States,” she said. “A disaster that affects only our company, we’re very confident in our ability to recover. This is far-reaching. It’s making us think.” Wait. Stop. Relax.

This scenario is just an emergency planning exercise. There’s no pandemic and the avian flu hasn’t spread in large numbers to humans.

But public health officials around the world aren’t waiting for that to happen. And at their prodding, neither is corporate America. They’re preparing now, just in case their worst nightmare comes true.

“My hope is that these businesses don’t ignore this and then it becomes a problem of government to try to fix their problem in retrospect,” said Dr. Anthony J. Billittier IV, Erie County health commissioner. “Government won’t be able to do it. Look at Katrina.”

From insurers and banks to grocery store chains like Wegmans, companies large and small nationwide are developing “contingency” plans to deal with a range of possible effects of a widespread flu pandemic.

The H5N1 virus has already spread rapidly among bird populations in Asia, Europe and Africa, and infected more than 329 people in 12 countries, killing 201, according to the World Health Organization. The virus has not yet shown the ability to jump from person to person, but experts who have been monitoring it for eight years say that’s just a matter of time.

It wouldn’t be the first. In 1918, the “Spanish flu” pandemic killed an estimated 40 million people worldwide. Two other pandemics in 1957 and 1968 also caused significant deaths but not to the same degree.

The impact of a new pandemic on society and the economy could be severe. A report this year by Trust for America’s Health said a severe pandemic could lead to the second-worst U.S. recession since World War II. New York state’s economy alone could lose $50 billion.

So businesses are taking precautions, especially if they operate globally. They’re looking at how to cope with the loss of a major portion of staff, how to contain the disease, how to keep operations running, and how to serve customers.

“A bank of the size and complexity of HSBC has to have in place detailed plans to deal with any possible threat to its business,” said Francine Minadeo, spokeswoman for HSBC Bank USA, whose London-based parent is stockpiling drugs.

They’re also exploring every possible secondary disaster scenario, from fixing computer problems when the tech guy is sick to maintaining food deliveries into a building.

“M&T, like any organization, is aware of the fact that the possibility of a pandemic exists. So we prepare for it just like any other event that could happen,” said Jeff Shaw, information security compliance administrator, who manages M&T Bank Corp.’s business continuity effort. “It’s just being prudent.”

The financial services industry is among the most advanced in planning, because it’s highly regulated and those regulators want to ensure the nation’s financial system remains intact. Banks and insurers must have “business continuity” plans in place for a wide range of emergencies, and must test them and update them to ensure they would work. The flu efforts have been under way for two years, since November 2005.

“Bank of America actively tests business preparedness plans, processes and back up operations,” spokeswoman Kelly Sapp said by e-mail. “We continue to use simulations and other measures . . . to prepare for all types of scenarios.”

“We have a responsibility to our customers and our franchise and our employees to make sure that we have a healthy work environment and can meet our customers’ needs,” said Greg Gist, senior vice president in Citigroup’s Corporate Office of Business Continuity. “The risk of not being prepared, to me, carries 10 times more the consequences than the risk of being [overly] prepared.”

That’s why more than 2,725 banks, insurers and brokerage firms around the country — including Merchants, M&T, Bank of America and Citi — are currently participating in a threeweek exercise aimed at testing disaster plans in the event of a pandemic. The test began Sept. 24, and ends Thursday.

The exercise — the largest ever of this type in the United States — is designed to simulate as best as possible the conditions that companies would face when the virus hits America. That’s based on the estimates and predictions of scientists and medical researchers at Centers for Disease Control and the World Health Organization.

It’s sponsored by the U.S. Department of the Treasury and the Securities Industry and Financial Markets Association.

At its core, the test expects about 25 percent of a company’s staff to be absent the first week, and almost half the second.

It then presents a series of changing conditions affecting travel, the stock market, and other factors, and poses an array of specific worst-case scenarios to see whether the companies have a plan, and how they would respond.

“What we’re trying to do is recreate as much as we can what would happen should a pandemic eventually reach America,” said Louis W. Pietroluongo, deputy New York state In two incidents last month of avian influenza infecting chickens: at left, a worker disinfects a poultry truck near Nuremberg, Germany; at right, a health official throws an infected bird into a fire pit in Surabaya, Indonesia.

superintendent of insurance for disaster preparedness and business continuity planning. “We can’t explore all of these things, but what we’re trying to do is come down the middle of the road.”

Merchants even added its own twist, creating an additional problem involving its own personnel or equipment each day for team members to solve.

“We thought it might be interesting to put the immediate spin on it,” Merchants spokeswoman Lisa Wishman said. “It’s an eye-opening exercise.”

Many businesses have long had contingency plans and emergency response teams in place should a particular bank branch, office building, store, operations facility, city or entire region be affected by a disaster.

The goal is to make sure the business can operate through the event, without impeding customers and without losing any records or information.

In the past, companies prepared for hurricanes, tornados, floods, earthquakes, blizzards, fires or other natural disasters, as well as for events such as blackouts that could be unrelated to weather. More recently, they’ve added terrorism events like “dirty bombs” to the list, especially in high-profile areas.

But preparing for a worldwide flu pandemic is much different. Rather than affecting just a limited geographic area or even a single building, a pandemic would hit the entire country. And it would last for 12 to 18 months, in multiple waves, instead of a few minutes or hours.

“Very few companies if any have ever planned for something like this,” Gist said. “Most companies are using this as an opportunity to take their planning to a new level of maturity. There is no one silver bullet.”

First, companies are prioritizing their work and learning what resources are available to them. Many would transfer work from one operations center to another that wasn’t hit as hard, or even to another department within the same facility.

“The projected waves of a pandemic may be regional in nature or affect only a limited area,” Karen Merkel-Liberatore, spokesman for Buffalo-based HealthNow New York.

Employees also are being actively cross-trained in multiple functions, and companies are identifying key people to fill critical roles. And significant work is already automated.

Many companies like M&T, Citi and KeyBank are considering whether employees can do work from home to avoid exposure, and are assessing whether they have enough Internet “bandwidth” to handle such an increase in Web traffic. Indeed, that’s become a major question.

“It’s such a great unknown,” said M&T’s Shaw. “We’ve never pushed the limit of the Internet to this point where we know what this would do to us.”

KeyBank officials are looking at whether they could handle more activity through call centers, online banking, and ATMs, since many routine activities can be done remotely, said spokesman William Murschel.

Billittier said some banks have talked of closing branch lobbies to minimize physical contact.

And Citi is making sure its human resources policies consider “situations that we haven’t thought of before,” Gist said, such as the need for a single parent to stay home with children if schools are closed.

Pietrolongo said companies also need to maintain building security to keep sick people from coming to work, and might need to provide cafeteria service around the clock. And they have to consider the psychological impact on workers.

“You’re going to have a lot of people dying. It’s a human scenario,” he said.

HSBC, with its global reach in 83 countries and territories, has gone a step further. After seeking advice from leading experts on avian flu, the company is purchasing and stockpiling the anti-viral drug Tamiflu that has been recommended by the World Health Organization. The drug would be available to all employees and, where possible, could be purchased for their family members.

“This risk is very much a people issue and therefore we have planned with the protection of our employees and their families, and our customers, in mind,” Minadeo said by e-mail.

Still, many nonfinancial businesses are betting against an outbreak. And that concerns experts like Billittier.

“It’s important that they have some sort of planning. There’s so many things that we’re vulnerable to,” he said. “It’s not just about pandemic flu.”
 

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Indonesian woman dies from bird flu after buying chickens at local market

http://english.pravda.ru/news/world/08-10-2007/98334-bird_flu-0

According to Indonesian Health Ministry official, woman has died from bird flu after buying chickens at a local market, lifting the national death toll from the disease to 87.

Blood tests confirmed the woman, 44, had the deadly H5N1 strain of the disease, said Joko Suyono.

Indonesia has been hardest hit by the virus since it began ravaging poultry stocks across Asia in 2003. Its human death toll now accounts for almost half of the recorded 200 fatalities worldwide, according to the World Health Organization.

Investigators were still trying to verify how the woman was exposed to the virus, usually fatal for poultry but hard for humans to contract, Suyono said.

Most human cases so far have been traced to contact with infected birds, but experts fear the virus could mutate into a form that spreads easily between humans, potentially sparking a global pandemic.

Indonesia, the world's fourth most populous country and home to millions of backyard chickens, is considered a possible hot spot for that to happen. So far, there have been 108 confirmed cases of H5N1 in humans.
 

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Indonesia announces 8 suspected bird flu patients

http://www.kuna.net.kw/NewsAgenciesPublicSite/ArticleDetails.aspx?id=1846719&Language=en

Health 10/8/2007 6:28:00 PM

KUALA LUMPUR, Oct 8 (KUNA) -- Eight suspected bird flu patients were admitted to Adam Malik Hospital in Indonesia's North Sumatran city of Medan Sunday night, a hospital spokesman said on Monday.

The condition of six of the patients has begun to improve while that of the two others, a pregnant women and a three-year old toddler, remained serious, the Antara news agency quoted the spokesman The spokesman, M Nur Rasyid Lubis as saying.

"The condition of the two other patients is still worrisome," he said said.
However, he added there were no indications that the eight patients had bird flu because their condition was improving.

"We are still waiting for laboratory test results to determine whether they are bird flu positive or not," Nur Rasyid said, adding that the patients had had direct contact with dead poultry.

Meanwhile, the Health Ministry said early this month that a male resident of Rawa Buaya in Cengkareng, West Jakarta, who died of bird flu on September 28, had brought the total number of people so far affected by the virus in Indonesia to 107 and the number of deaths by the disease to 86, Antara said.

The ministry said tests carried out on the blood samples of the man, identified only by his initial as AR, by its Research and Development Laboratory had shown that he was infected with the bird flu virus.

In Jakarta alone, the number of bird flu cases has been recorded at 26 of which 23 have ended in the death. (end) asf.msa KUNA 081828 Oct 07NNNN
 

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Bird flu strikes as fears grow

http://news.independent.co.uk/world/asia/article3041072.ece

AP
Published: 09 October 2007

An Indonesian woman has died from bird flu after buying chickens at a local market, lifting the national death toll from the disease to 87, a Health Ministry official said.

Blood tests confirmed the woman, 44, had the deadly H5N1 strain of the disease, said Joko Suyono.

Indonesia has been hardest hit by the virus since it began ravaging poultry stocks across Asia in 2003. Its human death toll now accounts for almost half of the recorded 200 fatalities worldwide, according to the World Health Organization.

Investigators were still trying to verify how the woman was exposed to the virus, usually fatal for poultry but hard for humans to contract, Suyono said.

Most human cases so far have been traced to contact with infected birds, but experts fear the virus could mutate into a form that spreads easily between humans, potentially sparking a global pandemic.

Indonesia, the world's fourth most populous country and home to millions of backyard chickens, is considered a possible hot spot for that to happen. So far, there have been 108 confirmed cases of H5N1 in humans.
 

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Quarantine lifted in bird flu-hit village

http://www.chinadaily.com.cn/china/2007-10/09/content_6161211.htm

Updated: 2007-10-09 19:55

GUANGZHOU -- South China's Guangzhou City on Tuesday removed the quarantine order on a village where an outbreak of a bird flu killed 9,830 ducks in early September.

The city authorities announced, after a final check on Monday, that no more poultry cases had been reported since a cull of poultry 21 days ago in Sixian Village, Xinzao Township of Panyu district, and no human cases of bird flu found.

The Ministry of Agriculture confirmed the outbreak as a sub-type of the H5N1 bird flu strain on September 17. It started with the mass deaths of ducks in the village on September 5.

Local authorities ordered the village to be quarantined, culling an additional 153,320 domestic fowl to prevent the spread of the disease, disinfecting all contaminated areas and closing 68 poultry and related products markets within a radius of 13 kilometers.

The district government reopened the markets on Tuesday.

Animal-related diseases, such as bird flu, were frequently reported during autumn and winter, increasing the need for controls, said Zhou Caixin, vice head of Guangzhou Agriculture Bureau.

The last previous reported case of H5N1 bird flu in China occurred in May in Central China's Hunan Province, where more than 11,000 birds died of the disease and 52,800 were culled.

As the world's largest producer of poultry, livestock and aquatic products, China has suffered huge economic losses from outbreaks of animal diseases. It is estimated that animal diseases cost China 40 billion yuan (US$5.3 billion) annually.
 

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Gaps in European flu pandemic plans could produce chaos: study

http://afp.google.com/article/ALeqM5jmG33koxHqHrgA5QN6ROVU4RlJAw

3 hours ago

GENEVA (AFP) — European plans to cope with a possible flu pandemic have major weaknesses which might lead to chaos, a study published by the World Health Organisation said Tuesday.

The study of 29 European countries by scientists at the London School of Hygiene and Tropical Medicine said authorities must urgently tackle shortcomings in preparation for vaccine and antiviral drug distribution, insufficient stockpiles, and incoherent plans for border controls.

It warned that many European governments risked "chaotic service responses and public anxiety" by leaving it up to regional or local authorities to organise drug delivery during a pandemic and giving them little guidance.

"Our findings show that even in Europe, which may be better prepared than some regions, considerable gaps and inconsistencies persist and several areas of operational planning have not been addressed," the study published in the October issue of the WHO Bulletin said.

The authors concluded that "the remaining gaps and inconsistencies need urgent attention" despite outwardly strong government commitment in Europe and strengthened planning since their last evaluation in 2005.

Scientists fear that the H5N1 strain of bird flu, which emerged in humans in Asia in the 1990s, could mutate into a more virulent form that could easily be passed between humans, triggering a global flu pandemic with the potential to kill millions.

Some 329 people have contracted H5N1 bird flu since 2003, of whom 201 have died, according to the WHO. Most of the human cases have been in Asia but it has also spread to the Middle East and Nigeria.

The outbreaks triggered a WHO-led drive in recent years to bolster preparedness for a pandemic, including stockpiling of antiviral drug treatments, greater vaccine research and advance emergency planning.

The study said only half the countries had developed full storage and delivery strategies for antiviral drugs, particularly as a preventive treatment to slow the spread of pandemic flu.

"The issue of how to deliver antivirals within 48 hours to individual patients remains largely unresolved," it added.

Vaccine strategies had "important gaps" and only a minority of the countries surveyed had guidelines on vaccine storage, distribution and administration during an emergency.

One country did not have plans for pandemic vaccination at all.

There is currently no known vaccine against pandemic flu as one would have to be developed and produced rapidly to match the emerging strain at the time.

The authors also said that shortcomings in planned checks on travellers were likely to be "politically volatile during a pandemic."

Planning for border controls, quarantines or travel restrictions varied widely, and many countries ignored WHO recommendations favouring exit-screening for travellers to stop the spread of pandemic flu, the study found.

Only half of the countries explictly planned to coordinate their border controls with neighbours, 19 favoured screening travellers on entry, while 10 did not plan to screen travellers at all, it added.

The study was meant to cover the 27 European Union member states, Norway, Switzerland and Turkey, but one unidentified nation was not included in the final analysis.
 

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Bird flu virus strain in Vietnam mutates

http://news.xinhuanet.com/english/2007-10/10/content_6857409.htm

HANOI, Oct. 10 (Xinhua) -- Bird flu virus strain in Vietnam has mutated, becoming more dangerous, local newspaper Pioneer reported Wednesday.

However, the mutation is not big enough for the virus to transmit among humans, the paper quoted Vietnamese Minister of Agriculture and Rural Development Cao Duc Phat as saying at a meeting of the country's Anti-bird flu Central Steering Committee on Tuesday.

The vaccination among poultry is still effective in preventing the disease due to the high compatibly between the vaccine and the virus, he said.

Vietnam is encountering high risk of bird flu reoccurrence late this year, when cold weather condition is more favorable for the development of viruses, he said.

The minister has asked local relevant agencies to focus on intensifying disease surveillance, monitoring of poultry raising, transporting and trading, and vaccination among fowls nationwide.

Vietnam has detected seven bird flu patients from the five northern provinces of Vinh Phuc, Thai Nguyen, Thanh Hoa, Ha Nam and Ha Tay since May 10, of whom four died, according to the Preventive Medicine Department under the Vietnamese Health Ministry.

Bird flu outbreaks in Vietnam, starting in December 2003, have killed and led to the forced culling of dozens of millions of fowls in the country, according to the Department of Animal Health under the Ministry of Agriculture and Rural Development.
 

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Avian, human flu virus cell types are ID'd

http://www.earthtimes.org/articles/show/122050.html

Dutch scientists have identified the respiratory tract sites and cell types targeted by human versus avian influenza viruses.

Professor Thijs Kuiken and colleagues at the Erasmus Medical Center in Rotterdam said their findings provide valuable insights into the pathogenesis of the divergent diseases.

To elucidate the differences between low and highly pathogenic avian influenza virus versus human influenza virus, the researchers said they used a technique called virus histochemistry that examines the attachment pattern of an influenza virus to isolated respiratory tissues, thus identifying the cells targeted by the virus.

When human viruses were tested, both attached strongly to the trachea and bronchi but virus binding to the bronchioles and alveoli was less abundant in comparison. In contrast, viral attachment of avian viruses was rare in the trachea, but more abundant in the bronchioles and alveoli.

The detailed study is featured in The American Journal of Pathology.
 

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Bird flu returns to Vietnam

http://rawstory.com/news/dpa/Bird_flu_returns_to_Vietnam_10112007.html

dpa German Press Agency
Published: Thursday October 11, 2007

Hanoi- After months of no reported cases of avian
influenza, ducks in Vietnam's Mekong Delta have tested positive for
the virus, a local official said Thursday.

Samples taken from ducks at a farm in southern Vietnam's Tra
Vinh province have confirmed the presence of the H5N1 virus, said Le
Tuyet Hong, head of the animal health department of Tra Vinh
province.

"We have culled all the ducks in the farm and put a ban on
transporting poultry out of the village," said Hong. "We have also
disinfected the area and other farms in the entire village. We are
trying to keep the outbreak from expanding to other villages as it is
very easy for the virus to spread in cool weather."

The last reported outbreak of the bird flu in Vietnam was in
August. The country was declared bird flu-free in September but
veterinarians warned that the virus could reappear.

Animal health authorities have been told by the government to
vaccinate poultry flocks before any more cases appear. Each year,
Vietnam immunizes hundreds of millions of chicken and ducks.

But the shots do not guarantee immunity. Ducks, which often roam
free, have to be immunized several times.

Earlier this week the Health Ministry said that bird flu
checkpoints would be established across the country to prevent the
spread of the virus if another outbreak occurred.

Vietnam has been one of the country's hardest hit by the avian
influenza. At least 46 people have died from the virus, which can be
passed to humans who come in contact with uncooked poultry or the
poultry's faeces.
 

JPD

Inactive
Avian Flu -- 1918 and Today -- Protein Enhances Lethality Of Virus

http://www.sciencedaily.com/releases/2007/10/071010120543.htm

Science Daily — Often called the most devastating epidemic in the recorded history of the world, the 1918 influenza virus pandemic was responsible for more than 40 million deaths across the globe. The incredible lethality of the 1918 flu strain is not well understood, despite having been under intense scrutiny for many years. Now, a new study published by Cell Press in the October issue of the journal Cell Host & Microbe unravels some of the mystery surrounding the devastating 1918 pandemic and provides key information that will help prepare for future pandemics.

It is relatively rare for an influenza virus to be virulent enough to cause death in healthy humans. Many deaths associated with influenza are caused by the combined influence of viral disease and the following secondary bacterial infection. Although the 1918 pandemic strain was one of the few influenza viruses capable of killing healthy victims on its own, the majority of fatal cases from the "Spanish Flu" can be attributed to secondary bacterial pathogens rather than primary viral disease. This important interaction between influenza viruses and bacteria is not well understood.

Dr. Jonathan A. McCullers from the Department of Infectious Diseases at St. Jude Children's Research Hospital in Memphis, Tennessee and colleagues examined this interaction by studying a newly discovered influenza A virus (IAV) protein, called PB1-F2. The gene encoding PB1-F2 is present in nearly all IAVs, including highly pathogenic avian IAVs that have infected humans and the IAV associated with the 1918 pandemic. "PB1-F2 was recently shown to enhance viral pathogenicity in a mouse infection model, raising questions about its effects on the secondary bacterial infections associated with high levels of influenza morbidity and mortality," explains Dr. McCullers.

The researchers found that expression of PB1-F2 increased the incidence of and exacerbated secondary bacterial pneumonia in a mouse model. Intranasal delivery of a synthetic peptide derived from a portion of PB1-F2 had the same effects. Further, an influenza virus engineered to express a version of PB1-F2 identical to that in the 1918 pandemic strain was more virulent in mice and led to more severe bacterial pneumonia, explaining in part both the unparalleled virulence of the 1918 strain and the high incidence of fatal pneumonia during the pandemic.

The finding that PB1-F2 promotes lung pathology in primary viral infection and secondary bacterial infection also provides critical information for the future. "Given the importance of IAV as a leading cause of virus-induced morbidity and mortality year in and year out, and its potential to kill tens of millions in the inevitable pandemic that may have its genesis in the viruses currently circulating in southeast Asia, it is imperative to understand the role of PB1-F2 in IAV pathogenicity in humans and animals," says Dr. McCullers. "These findings also reinforce the recent suggestion of the American Society for Microbiology that nations should stockpile antibiotics for the next pandemic, since many of the deaths during this event are likely to be caused by bacterial super-infections."

Reference: McAuley et al.: "Expression of the 1918 Influenza A Virus PB1-F2 Enhances the Pathogenesis of Viral and Secondary Bacterial Pneumonia." Publishing in Cell Host & Microbe 2, 240--249, October 2007. DOI 10.1016/j.chom.2007.09.001

The researchers include Julie L. McAuley of Department of Infectious Diseases, St. Jude Children's Research Hospital in Memphis; Felicita Hornung of Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases in Bethesda; Kelli L. Boyd of Animal Resources Center, St. Jude Children's Research Hospital in Memphis; Amber M. Smith of Department of Mathematics, University of Utah in Salt Lake City; Raelene McKeon of Department of Infectious Diseases, St. Jude Children's Research Hospital in Memphis; Jack Bennink and Jonathan W. Yewdell of Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases in Bethesda; and Jonathan A. McCullers of Department of Infectious Diseases, St. Jude Children's Research Hospital in Memphis.

This work was supported by the NIH the NIAID intramural research program, and the American Lebanese Syrian Associated Charities (ALSAC).
 

JPD

Inactive
Tests clear 5 bird flu suspects in Indonesia

http://www.brunei-online.com/bb/thu/oct11w9.htm

JAKARTA (AFP) - Two tests on five people from Indonesia's North Sumatra, feared to be a new cluster of human bird flu, have cleared them of carrying the virus, a health ministry official said Wednesday.

"Their test results were all negative," said an official on duty at the health ministry's Bird Flu Information Center, who only identified himself as Momo.

Two tests, usually of samples of blood and tissue, must come back positive for the virus before a victim is confirmed as infected in Indonesia, where the death toll of 87 from avian influenza is the highest in the world.

However, the official could not say why the results of two other suspects were unavailable or when they would be available.

The seven people, including a pregnant woman and a three-year-old child, came from the same village of Telaga Tujuh, in North Sumatra.

They were admitted to a referral hospital in the provincial capital Medan on Saturday, with symptoms similar to those caused by the deadly H5N1 virus strain of the avian flu.

Sinar Ginting, the hospital spokesman, said information from the local animal husbandry office said many chickens had recently died in their neighbourhood and that some had tested positive for bird flu.
 

JPD

Inactive
Indonesian teenager hospitalised for bird flu

http://www.vnanet.vn/Home/EN/tabid/119/itemid/217722/Default.aspx

11/10/2007 -- 9:44 PM
Ha Noi (VNA) – An Indonesian boy has tested positive for bird flu and is being treated in a Jakarta hospital, the Health Ministry said.

The 12-year-old boy from the Jakarta suburb of Tangerang started to develop bird flu symptoms last week, and reportedly had contacts with infected chickens, the ministry said in a statement.

The latest case brings total bird flu cases in human in Indonesia to 109, with 87 deaths or the highest among other affected countries.-Enditem
 

JPD

Inactive
Banks Preparing for Bird Flu, and So Should You

http://www.thestreet.com/s/banks-pr...funds/saving-money/10383866.html?puc=_tsclsii

By Jeffrey Strain
Special to TheStreet.com
10/11/2007 10:55 AM EDT

Scientists believe that the H5N1 bird flu virus, or some other form of flu, will eventually mutate so that it can easily be passed from human to human and become a pandemic. Researchers announced last week that the H5N1 flu virus has mutated in a way to make it possible to infect people more easily by allowing it to grow in the upper respiratory tract of humans.

Realizing the threat, President Bush directed various government agencies to upgrade their planning for pandemic outbreaks in May of last year. In response, 2,700 financial institutions are taking part in a three-week long simulation that began Sept. 24 to test their response to a potential pandemic.

The financial institutions are running this scenario to be better prepared to deal with the situation if it actually happens and to think through steps they should implement to keep their business running. You should be making the same preparations on a personal finance level.

Here are a number of questions that you should be asking yourself and steps you should be taking:

Have you taken care of the basics? If you don't already have a financial emergency kit in place, preparing one is the first step you should take. While a pandemic is different from a natural disaster, both have areas of financial preparation which overlap and you might as well be prepared for all emergencies.

What do you need to be prepared? You should spend some time considering all the things that you're going to need if a pandemic breaks out. You should stock up on things that you can buy now that will likely become more scarce if a pandemic begins -- such as surgical masks to help keep you from breathing in germs -- while there is a large supply.

You'll also want to make a list of things that you will want to stock up on right away when it appears an outbreak is taking place. For example, ATMs may quickly run out of cash and with many workers calling in sick, may not be replenished.

Gas will also likely be hard to come by, as the people needed to refine and transport it to gas stations won't be available.

Also consider that you will need to change your habits during this time. You will not want to be in crowded places, meaning that you will want to keep shopping to a minimum.

You will need to make sure to thoroughly wash your hands several times a day -- which is a good habit to get into anyway. By preparing what you can well ahead of time and having a list of exactly what you will need, you will be in a much better position than most if a pandemic does occur.

What will you do with your children? If you have children, you need to come up with a plan on what to do with them. In the event of a pandemic, schools and day care centers are likely to shut down. Alternative day care will likely be difficult to find, meaning that unless you have created alternative plans ahead of time, you will likely find yourself staying home with them.

You may want to set up a plan with a couple of friends, where you take turns taking care of the kids. By thinking through and creating a plan ahead of time, you will have a solution to this issue while others are scrambling.

What will happen if you're out of work several weeks? If you have kids that get sick or you get sick yourself, it is likely that you will not be able to go into work for several weeks. You need to make sure that you have enough in your emergency fund if you are forced to stay home during this time. You may also want to talk to your boss to see if you will be able to telecommute during this time or make other arrangements if you can't come into work.

Are you prepared in case of death? While death isn't fun to think about, it's something for which you need to prepare. If the next pandemic is anything like the 1918-1919 influenza outbreak that killed tens of millions of people, many of them in the prime of their lives, you will be glad that you put your estate in order.

Many young families fail to prepare for death because they don't feel they need to. If you have been putting off this part of your financial plan, this is a good reason to tackle it right away. You should review your life insurance to make sure you have adequate coverage. In addition, you should make sure that your will, medical power-of-attorney documents and other estate documents are all up to date.

While you hopefully will never need to use any of these preparations, having gone through the process will make your finances stronger. And if the planning is needed in the future, you'll be patting yourself on the back for taking the initiative to prepare ahead of time.
 

JPD

Inactive
From Flu to Superflu

http://sciencenow.sciencemag.org/cgi/content/full/2007/1011/2

By Steve Mitchell
ScienceNOW Daily News
11 October 2007

Just in time for flu season comes the discovery that a single protein may largely explain the unprecedented deadliness of the 1918 influenza epidemic. The finding should help infectious disease experts spot future flu viruses that pose the most risk of causing another global pandemic.

The 1918 outbreak--also known as the Spanish flu--was the deadliest strain of flu virus the world has ever seen (ScienceNOW, 17 January). Estimates of fatalities range from 40 million to 100 million. Some people fell victim to the flu virus itself, but many of the deaths were due to the pneumonia that people developed as a result of damage to their lungs. Why was the virus so deadly? Scientists suspect that a recently discovered protein called PB1-F2, which is found in many flu viruses, including the H5N1 bird flu strain that has killed 202 people, may hold some answers.

To get a better handle on the role of PB1-F2 in the 1918 epidemic, a team led by Jonathan McCullers, a virologist at St. Jude Children's Research Hospital in Memphis, Tennessee, genetically modified a mouse strain of flu virus to produce a PB1-F2 protein identical to that in the 1918 strain. When the researchers dripped high doses of the modified virus into the noses of mice, all of the animals died within 8 days and had more lung inflammation than animals receiving similar doses of the same flu virus with unaltered PB1-F2.

In a separate experiment, the researchers gave mice nonlethal doses of the modified flu virus and then infected them with the pneumonia-causing bacterium, Streptococcus pneumoniae. All of the animals died within 4 days and showed evidence of severe pneumonia, the team reports in the October issue of Cell Host & Microbe. In contrast, 80% of the mice that received the unmodified virus were alive 4 days after exposure to the pneumonia bacterium and 20% were still alive when the study ended at 14 days.

"This is one of the big reasons 1918 was so bad, because PB1-F2 allowed bacteria to cause more problems due to lung inflammation and damage," McCullers says. How PB1-F2 amplifies flu virulence remains uncertain, but he says the protein could be a potential target for flu drugs, with the goal being to suppress it to help reduce lung damage and subsequent pneumonia.

Terrence Tumpey, a microbiologist with the Centers for Disease Control and Prevention in Atlanta, Georgia, says monitoring the PB1-F2 protein in flu viruses could help determine which ones pose the most threat to public health. "It could help us recognize if a particular virus is something we have to watch out for," Tumpey says.
 

JPD

Inactive
All poultry culled at S. Russian farm after bird flu outbreak

http://en.rian.ru/russia/20071012/83650000.html

KRASNODAR, October 12 (RIA Novosti) - About 250,000 birds have been culled at a poultry farm that was the site of an outbreak of bird flu in early September in the Krasnodar Territory, south Russia, local officials said on Friday.

"All poultry on the farm have been slaughtered. The state of emergency in the region following the outbreak of bird flu has been lifted," the spokesman said.

No other bird flu cases have been registered in the region, he added.

The lethal H5N1 virus was identified at the farm after some 500 chickens died on September 4. About 22,000 birds were slaughtered the day after the infection was confirmed.

In 2005, 1.3 million birds were culled in Russia, and in 2006 the figure stood at 1 million. This year, however, the figure has dropped to around 260,000.

Since late 2003, when the virus first hit Asia, the deadly H5N1 strain of bird flu has killed at least 191 people, according to World Health Organization statistics.

No human deaths from bird flu have been recorded in Russia.
 

Tink

Veteran Member
I wonder why migratory birds with H5N1 haven't shown up in the U.S. yet? Weren't they expecting them a year or so ago?
 

kelee877

Veteran Member
from what I have come to understand is at first migratory birds where not carrying Bird FLU, but now they are..it was just showing up in chickens and ducks..now it has spread to migratory birds..chickens and ducks that where getting Bird flu, where picking it up when being transported to live markets...or being brought into farms by vehicles..even the bird poop is highly contagious and when it dries it is in powered form

also there are 3 main migratory bird pathways...and it is when they all meet that the spread can happen...Sping when the birds return here will be the test if migratory birds are spreading...


also it has now been proven that even thou these countries that have Bird Flu are giving their birds a vaccine the vaccine is masking the flu and it can still be passed on to humans...

lots to watch and learn..
 

JPD

Inactive
Bird flu, pig disease return to Mekong Delta as weather cools

http://vietnamnews.vnagency.com.vn/showarticle.php?num=02HEA131007

(13-10-2007)

HCM CITY — Bird flu is recurring in the Mekong River Delta as the weather turns from hot to cold in the last months of the year, according to the region’s animal health officials.

The Animal Health Department on Thursday said of the 300 ducks on a farm in Tra Cu District, Tra Vinh Province, five dead ducks had been tested positive for the deadly H5N1 virus.

The flock had come from different places, and had not yet been vaccinated.

Local veterinary workers culled infected water fowl immediately after the blood test results, and quarantined the affected area to prevent the spread of the virus.

The National Steering Committee for Avian Flu Control and Prevention is urging provinces and cities nationwide to promote vaccinations for poultry to stem the spread of the virus.

Bird flu broke out in Viet Nam in May, ravaging provinces across the country. In September, Tra Vinh Province was the last locality in the Mekong region to be declared free of the virus.

Pig disease

Local animal health workers in Ca Mau City in the Mekong Delta Province of Ca Mau on Thursday destroyed nine pigs infected by pig disease to prevent its outbreak in the city and surrounding areas.

Over the last three weeks, local animal health workers in Ca Mau City culled 56 sick animals and collected blood samples for testing.

Medically called Porcine Reproductive and Respiratory Syndrome (PRRS), this blue ear disease first struck the central provinces of Quang Nam, Quang Ngai and Da Nang City in late June.

The disease then broke out in the Mekong Delta Province of Long An in late July. Local veterinarians have destroyed 32 out of 40 infected pigs on a farm in Can Giuoc District.

In the last two days, local veterinarians in Khanh Hoa Province’s districts of Dien Khanh, Cam Lam, and Ninh Hoa and Nha Trang City culled 270 pigs infected by the disease.

As of October 11, Khanh Hoa, Ca Mau and Lang Son Provinces were reportedly still trying to control the disease—VNS
 
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