7/14/07-7/20/07|Weekly Bird Flu Thread: Where in the world is the H5N1 virus?

JPD

Inactive
Where in the world is the H5N1 virus?

http://scienceblogs.com/effectmeasure/2007/07/where_in_the_world_is_the_h5n1.php

Posted on: July 13, 2007 7:34 AM, by revere

The bird flu stories from Indonesia have a sameness to them so it is sometimes hard to remember these are real people. Someone's little girl or boy, sister, brother, father, cousin, best friend. They are just another "6-year-old boy died of bird flu at the weekend, a health official said on Thursday." I'm not blaming anyone of heartlessness. This is a normal way to react. It is also normal to think you know how the disease is transmitted and if you see a circumstance remotely like your pre-conceived notion, you stop searching for other causes. But in the case of the 6 year old just mentioned, the "usual cause," contact with sick poultry isn't in evidence.

The boy, from the city of Cilegon in Banten province, suffered from high fever and breathing difficulties before he died of multi-organ failure on Sunday.

Contact with infected fowl is the most common way for humans to contract the H5N1 virus, but so far no clear link in this case has been established, officials said.

It is always a concern when the cause of a human infection cannot be traced as it makes infection control more difficult.

Runizar Ruesin, the head of the health ministry's bird flu centre, said that at least 20 of chickens near the boy's school had died suddenly.

"But we are still investigating whether he had a contact with sick or dead chickens in the neighbourhood," the official said.

A spokeswoman at the Jakarta hospital where the boy was treated said that along with some chickens dying near the boy's school there were also water fowl in the school area.

"There are a lot of water fowl roaming near the boy's school although they probably didn't get into the school," said Tuty Hendrarwardati, a spokeswoman for the Sulianti Saroso hospital. (Reuters)

Maybe they'll find a connection. Then they'll be satisfied. But it is true that a fairly large proportion of cases in southeast Asia and in Indonesia do not give good histories of contact with sick birds, although often there is mention of birds or sick poultry somewhere in the area. That seems to be good enough to assign birds as the source. In this case those birds seem to be hard to find. There are none within 300 meters of the boy's house. So the next stop is the zoo:

Sardikin Giriputro, deputy director of Jakarta's Sulianti Saroso hospital, where the boy died, said Tuesday that the boy had visited relatives who lived near a zoo elsewhere in Banten province four days before he fell sick. (The Standard)

Since zoo animals have become infected in Thailand, it's a thought. But there is also a mention the boy had a fever before going to visit his relatives. So the zoo remains just a thought.

Here's another one. Maybe it's not true that almost all cases are from infected birds. Maybe there are other reservoirs in the environment, animate or inanimate. There is some equivocal data from feral cats. What else? There has been very little systematic surveillance of wildlife other than birds for infection with this virus.

Maybe it's time to do it. Just a thought.
 

JPD

Inactive
70,000 birds killed at Czech H5N1 farms

http://www.bruneitimes.com.bn/details.php?shape_ID=36598

14-Jul-07

AROUND 70,000 birds have been killed at two Czech poultry farms where the H5N1 strain of bird flu, which is potentially fatal to humans, was confirmed this week, veterinary authorities said yesterday.

Czech authorities have also decided to kill a further 70,000 birds, mostly chickens and turkeys, on three nearby farms even though bird flu has not been detected there, veterinary service spokesman Josef Duben.

"Around 70,000 have been killed," at two farms near the village of Norin in the centre of the country where the virus was confirmed on Wednesday, he told AFP.

The two farms are within an exclusion zone thrown up after the first cases of H5N1 were detected in domestic Czech poultry last month.

"We are doing this preventively. It is a decision we have taken ourselves in discussion with European authorities," Duben said.

He added that the compensation for the latest cull is likely to be around 30 million koruna ($2.2 million).

He said decontamination of the poultry farms will continue over the weekend.

Since the initial Czech outbreak in June, other cases of the H5N1 strain of bird flu have been declared in France and Germany.

AFP
 

JPD

Inactive
Indonesia links human H5N1 death to sick chickens

http://today.reuters.co.uk/news/CrisesArticle.aspx?rpc=401&storyId=JAK60730

Sat 14 Jul 2007 7:04:52 BST

JAKARTA, July 14 (Reuters) - An Indonesian child who died of bird flu last weekend appears to have caught the virus from dead or sick chickens in the area carrying the disease, a health ministry official said on Saturday.

Contact with infected fowl is the most common way for humans to contract the H5N1 virus, but medical experts had initially struggled to pinpoint the source of the infection in this case.

It is always a concern when the cause of a human infection cannot be traced as it makes infection control more difficult.

"She had indirect contact with dead chickens near her school," Joko Suyono, an official at the ministry's bird flu centre, said by telephone.

The victim, from the city of Cilegon in Banten province, had initially been identified as a six-year-old boy, but Suyono said this was due to a mix up between the hospital where she was treated and a laboratory.

The official said that tests on dead chickens found near the girl's school showed they were infected with bird flu.

"We cannot know whether she touched sick chickens or not because she died. But we know surrounding her school the virus is endemic (in fowl)," he added.

Suyono said tests for the virus on people who may have had contact with the girl had proved negative and also said the findings in this case ruled out the possibility of the virus being transmitted between humans.

"So far, there have been no human-to-human cases in Indonesia," he said.

Bird flu is endemic in bird populations in most parts of Indonesia, where millions of backyard chickens live in close proximity with humans.

Indonesia has had 81 confirmed human deaths from bird flu, the most of any country in the world.

According to World Health Organisation data, globally there have been 192 human deaths out of 318 cases of the disease.
 

JPD

Inactive
Lapses in preparations for killer bird flu noted

http://www.gmanews.tv/story/51060/Lapses-in-preparations-for-avian-flu-noted

07/14/2007 | 04:56 PM

Despite the Philippines’ reputation of being free from avian influenza (bird flu), some lapses abound in procedures to prevent its spread, at least in Mindanao.

Online news site MindaNews (www.mindanews.com) reported Saturday that the admission came from Dr. Rafael Mercado, Mindanao coordinator of the Avian Influenza Task Force.

Mercado, who is also chief of the Department of Agriculture’s livestock division in Southeastern Mindanao, said last week’s confiscation of nearly 300 exotic birds smuggled from Indonesia should be a wake-up call to strengthen preparedness against the Highly Pathogenic Avian Influenza (HPAI) that has plagued Asian countries except Hong Kong, Singapore and the Philippines.

“It seems there are shortcomings," he said, adding the task force will conduct an immediate assessment of their preparedness in the aftermath of the confiscation.

Mercado said Mindanao’s proximity to Indonesia, where the fatality rate, 81 out of 101 people dead, from bird flu infection is high, is a serious matter.

He added Mindanao is under threat because the World Health Organization said there might be a possible avian flu pandemic in Indonesia, based on the deaths.

Also, Mercado said that in the disposal of the smuggled stock, lapses were evident because there was no appropriate gas chamber that can be used to kill the animals with carbon dioxide before incineration.

Mercado said another problem is the entry via the southern backdoor, of Indonesian nationals who might have been exposed to the virus in their home country.

While he said he does not want to appear alarmist, he stressed the need for preparations to keep the country on track against the “constant threat" of the flu.

“What if an infected stock slipped through our protection layers?" he asked.

He also denied allegations of confusing protocol on how to handle livestock, wildlife and other related stocks entering the country, especially from AI-infected countries.

“The protocol is simple. If there are no papers, it should be disposed of immediately," he said.

Mercado said the international protocol only calls that decimation should be done humanely and peacefully and that’s what they did, he said.

Mercado said they will campaign heavily especially in communities along coastal towns around Mindanao to improve information, education, and communication on the disease.

He said the task force will also continue tracking the stock brought in from Indonesia recently in reaction to reports that a number of birds, especially the more expensive ones, were kept by some personalities. - GMANews.TV
 

JPD

Inactive
Bird flu spreads to northwest Bangladesh

http://in.today.reuters.com/news/ne...R_RTRMDNC_0_India-284830-1.xml&archived=False

Sun Jul 15, 2007 4:57 PM IST147

DHAKA (Reuters) - Bird flu has spread to another district in Bangladesh forcing health and veterinary workers to cull 2,000 chickens, officials said on Sunday.

The latest case was reported from a village in Naogaon district, 250 km northwest of the capital, Dhaka, said a senior officer of the fisheries and livestock ministry.

Bird flu was first detected near the capital in March and has since spread mostly to northern districts.

Seventeen out of Bangladesh's 64 districts have been affected by the virus, but there have been no reported cases of human infection.

The virus has forced authorities to cull 257,000 chickens and destroy more than 2.2 million eggs since its outbreak.

About four million Bangladeshis are directly or indirectly associated with poultry farming.
 

JPD

Inactive
U.S. Not Ready for Outbreak, Say Americans

http://www.angus-reid.com/polls/index.cfm/fuseaction/viewItem/itemID/16496

(Angus Reid Global Monitor) - Most people in the United States believe their government would not respond properly to a national emergency, according to a poll by Ipsos-Public Affairs released by Associated Press. 59 per cent of respondents express little confidence in the administration’s preparedness to handle a major outbreak of an infectious disease.

Laboratory tests have confirmed the presence of the H5N1 strain of avian influenza in several countries around the world. The World Health Organization (WHO) has warned that the virus could mutate into a form that can be transmitted among people.

Since 2003, 317 cases of bird flu in humans have been confirmed, and 191 fatalities have been reported in 12 Asian and African countries.

In November 2005, U.S. president George W. Bush outlined the federal government’s plan to deal with a possible outbreak of pandemic influenza, saying, "Our strategy is designed to meet three critical goals: First, we must detect outbreaks that occur anywhere in the world; second, we must protect the American people by stockpiling vaccines and antiviral drugs, and improve our ability to rapidly produce new vaccines against a pandemic strain; and, third, we must be ready to respond at the federal, state and local levels in the event that a pandemic reaches our shores."

On Jul. 2, John Lange, the U.S. State Department’s special representative on avian and pandemic influenza, declared: "The H5N1 virus is highly persistent; it is spreading in poultry populations, and the threat that it will mutate to become a human pandemic continues. (...) At least 178 countries have drafted or finalized their national pandemic preparedness plans. (...) One element of such preparedness is the Community Mitigation Guidance prepared by the U.S. Centers for Disease Control and Prevention."

Polling Data

How confident are you that the U.S. government is prepared to handle a major outbreak of an infectious disease?

Very confident


9%

Somewhat confident


32%

Not too confident


33%

Not at all confident


26%
 

JPD

Inactive
Turkey Loss From Bird Flu Could Be Up to $600,000

http://www.wjla.com/news/stories/0707/439307.html

HARRISONBURG, Va. - Saturday July 14, 2007 3:14 pm

The loss from the discovery of avian influenza antibodies in turkeys at a Shenandoah County farm could be up to $600,000, according to the U.S. Department of Agriculture.

The USDA will reimburse the farmer the fair market value of the 54,000 turkeys in which the antibodies were discovered during routine pre-slaughter testing on July 6. The cost of destroying and disposing of the birds also will be paid, said Karen Eggert of the USDA'S Animal Health Inspection Service.

No new cases of avian flu antibodies have been detected in ongoing testing near the farm, Virginia Poultry Federation President Hobey Bauhan said.

The antibodies were most consistent with the low-pathogenic H5N1 strain of the avian influenza A, which poses no threat to humans, a Department of Agriculture statement said.

The discovery of the antibodies has led to increased precautions, including additional testing of flocks, especially within 6 miles of the farm that had the turkeys.

The additional testing caused slight delays for some farmers.

Charles Halterman, who owns a chicken farm west of Broadway in Rockingham County, said he sweated out a two-day delay in Pilgrim's Pride picking up his chickens for slaughter because he wasn't sure what would happen to the birds.

"You are just sort of hanging out there in limbo," he told The Daily News-Record of Harrisonburg.

The discovery of the flock with avian flu antibodies prompted Virginia's state veterinarian to ban all live poultry sales and shows until July 30, as well as the application of poultry litter on fields in 17 counties in and near the Shenandoah Valley.

Farmer Charles Garber said the litter ban was not a great hardship.

"This time of year, no one is putting down litter anyway," he said, adding it is typically spread as fertilizer in the spring and fall.

The poultry industry is a major economic contributor in the Shenandoah Valley, where about 900 of the state's 1,200 commercial poultry farms are located.
 

JPD

Inactive
Thailand

A man died of bird-flu-like symptoms

http://nationmultimedia.com/breakingnews/read.php?newsid=30040929

A man Sunday succumbed to bird-flu-like symptoms, the provincial public-health chief Dr Prajak Wattanakul said.

Prajak said the patient had high fever, cough, exhaust, and pneumonia.

"Test results will come out in one or two days. By then, we will be able to say whether he died of bird flu," Prajak added.

According to the doctor, the patient lived next door to his elder brother's cockfighting yard. Recently, some of the fowls died without clear reasons.

The Nation
 

JPD

Inactive
Control Of Bird Flu: The public must do its part

http://www.nst.com.my/Current_News/NST/Monday/Letters/20070716083822/Article/index_html

HEALTH Minister Datuk Dr Chua Soi Lek has just announced that Malaysia is free of bird flu in humans.
Soon, the Ministry of Agriculture and Agro-Based Industry will make a similar announcement for animals, for the third time.

Currently, all funds and activities are channelled towards declaring Malaysia a bird flu-free country. Everybody in the animal industry is not only hoping Malaysia will eventually be free but is confident this will eventually happen.

The question is, what should we do next to ensure that the disease does not return for the fourth time? The answer lies in the seriousness of our disease prevention and how far we’re prepared to go in preventing the virus from returning to Malaysia.

The only way the virus can return is if someone or something, intentionally or unintentionally, imports the virus into Malaysia. Therefore, steps must be taken to prevent such a re-entry.
The first step is to prevent the entrance of contaminated materials from infected countries, including chicken products and by-products. The import and, more importantly, illegal entry of chicken products and by-products from infected countries must be stopped immediately. This was efficiently done at the initial stage of the last outbreak.

However, enforcement at entry points alone is not good enough. The general public, particularly those involved in the chicken industry, must understand the danger of bringing contaminated materials into Malaysia and its adverse effects once bird flu is present in Malaysia. Bird flu not only destroys the poultry industry but also endangers human life and has significant knock-on effects on the economy.

One consistent factor in the last three bird flu outbreaks in Malaysia was free-range chickens reared in villages. The source of infection was narrowed down to fighting cocks brought into Malaysia from infected countries.

So far, no properly kept commercial chicken farms have been infected. It is clear that the main source of the bird flu virus in Malaysia — fighting cocks — must be controlled, and their entry completely stopped. At the same time, small-scale chicken rearing in villages incubates the bird flu virus and must be discouraged.

The suggestion of the Department of Veterinary Services Malaysia for the eradication of unsystematic chicken rearing in villages, and the proposed ban on the importation and keeping of fighting cocks should be implemented.

The government should impose strict controls on chicken-rearing and the importation of chicken products, by-products and live birds.

One major concern is the role played by wild waterfowl. It has been suggested that waterfowl carry the virus without showing signs of the disease, but are able to transmit the virus to domestic chickens. There must, therefore, be regular surveillance of wild birds to ensure they are not carrying bird flu virus, while good laboratory facilities for quick diagnosis must be established.

Rapid action teams have been formed in all states and are on permanent standby for quick action should suspected cases of bird flu be reported.

To ensure that the virus is not introduced to commercial chicken farms, many have installed improved bio-security. These include preventing water and wild fowl, people and vehicles entering farms.

The government and private commercial poultry farms in Malaysia are serious in trying to prevent the re-entry of the bird flu virus into Malaysia. Is the public equally determined to stop the virus?
 

JPD

Inactive
Official: no new case of bird flu in northern Thailand

http://news.xinhuanet.com/english/2007-07/16/content_6383777.htm

BANGKOK, July 16 (Xinhua) -- Thailand's northern Phichit Provincial Hospital announced on Monday that a man who had bird-flu-like symptom died of liver virus disease, not bird flu.

Doctor Suchart Theparak, deputy director of the hospital, said Wichian Boonraksa, 42, had not been in touch with any chicken.

He said Wichian had chronic liver disease and the condition was complicated with lung infections.

Wichian, who died on Sunday, highly arose worry about the deadly disease since he had fever, cough, exhaustion and pneumonia,which are all the symptoms of bird flu.

Thailand is among the countries hardest hit by the deadly H5N1 virus, having recorded 24 human cases (including 16 fatalities) since the outbreak in 2004.
 

JPD

Inactive
DelSite Biotech Prepares To Test Powder Bird Flu Vaccine

http://www.vaccinerx.com/news/bird-...-powder-bird-flu-vaccine-20070716-410-26.html

Monday, 16 July 2007

DelSite Biotechnologies Inc, a subsidiary of Carrington Labs, has recently received a large delivery of the H5N1 strain antigen. The H5N1 is more commonly known the most common strain of the avian flu.

DelSite intends to unite the antigen with the dry powder system that the company has developed, and already successfully tested.

If the bird flu vaccine can be given in a dry powder form, it could solve a couple of the challenges facing organizations trying to provide the vaccine widespread across the world, in preparation for a pandemic.

One problem that would be reduced would be the potential for storing the vaccine in countries without decent refrigeration practices, since a powder vaccine wouldn't need to be kept cold.

Also a powder vaccine administered through the nose would cut down on costs of medical personnel, since people could self-administer the vaccine nasally.

More information is available at www.carringtonlabs.com
 

JPD

Inactive
Chief vet warns farmers of new bird flu threat

http://www.timesonline.co.uk/tol/life_and_style/health/article2080596.ece

The Government has given warning that wild birds migrating to Britain over the next few weeks may be carrying the H5N1 strain of avian flu.

Debby Reynolds, the Chief Veterinary Officer, is ready to order birds to be kept indoors if farms are deemed to be at risk.

A risk assessment published by the Department for Environment, Food and Rural Affairs states that the highest risk is from birds that have passed through the Czech Republic, Germany and France. Last month there were three outbreaks of the flu strain in the Czech Republic, and three cases in southern Germany. There was also an outbreak in France this month and experts expect more cases.

The greatest threat is believed to be from the blackheaded gull, which returns to Britain from the area around the Baltic Sea. About 50,000 to 100,000 pairs of these gulls breed in the Czech Republic before leaving for other parts of Western Europe, including Britain. These birds could appear this month.

The other imminent threat is from the mallard, which will start returning to Britain next month. Mallards breed in large numbers throughout Europe, with 25,000 to 45,000 pairs in the Czech Republic and 200,000 to 400,000 pairs in Germany.

The experts do not yet know which bird species is spreading the virus but they believe that several species will move to Britain from infected areas.

Customs officers are making secret checks on flights from affected areas. Sniffer dogs are being used at Heathrow and Gatwick to identify illegal imports of poultry meat, cooked and raw, and eggs that may carry the H5N1 virus. Among the flights, passengers and baggage being screened for possible smuggled food are those from China, Russia, Egypt, Thailand and Vietnam.
 

JPD

Inactive
Pathogens on a plane

http://www.thebulletin.org/columns/laura-kahn/20070614.html

By Laura H. Kahn | 14 June 2007

In the movie Snakes on a Plane, crates full of venomous snakes escape from the cargo hold of a 747 as it flies from Honolulu to Los Angeles. The snakes terrorize and kill a large number of passengers. While many snakes are deadly, invisible "pathogens on a plane" is a far scarier scenario. And worse yet, pathogens such as viruses and bacteria really are on planes. Commercial aircraft could be considered the twenty-first century equivalents of plague ships.

The recent scare involving the Atlanta-based lawyer with extremely drug-resistant tuberculosis who flew in multiple aircraft from the United States to Europe is just one example of the role air travel now plays in the potential transmission of deadly diseases. The conditions in commercial aircraft for the spread of respiratory ailments such as influenza, severe acute respiratory syndrome (SARS), and tuberculosis are perfect. Flying at 30,000 feet in a narrow hollow tube for hours with people sneezing, coughing, and talking (and sometimes vomiting) while breathing dry, recirculated air is a perfect set up for disease transmission.

Given these conditions, it shouldn't come as a surprise that influenza, SARS, and tuberculosis have been transmitted on commercial aircraft. John Brownstein, Cecily Wolfe, and Kenneth Mandl found evidence for the spread of influenza by air travel ("Empirical Evidence for the Effect of Airline Travel on Inter-Regional Influenza Spread in the United States"), and curtailing air travel has been proposed as one strategy to control a flu pandemic ("Controlling Pandemic Flu: The Value of International Air Travel Restrictions"). Proximity to a person symptomatic with SARS appeared to be the greatest risk factor for acquiring that disease on a plane ("Transmission of the Severe Acute Respiratory Syndrome on Aircraft").

Fortunately, the risk of acquiring tuberculosis on a plane appears to be low. However, during one long flight, a highly infectious individual with multidrug-resistant tuberculosis transmitted the disease to four individuals seated within two rows of him and to two other persons seated further away ("Transmission of Multidrug-Resistant Mycobacterium Tuberculosis During a Long Airplane Flight").

In other words, no one wants to sit for hours on a plane near a sick individual.

Respiratory illnesses typically spread via airborne and droplet routes. Airborne transmission involves tiny particles containing pathogens that can remain suspended in the air for prolonged periods of time. Tuberculosis typically spreads by this method. Droplet spread involves larger particles that quickly settle out of the air. Some diseases (SARS and influenza among them) can spread by both routes.

Some pathogens (the influenza virus, for example) can also exist on nonporous surfaces for hours. Theoretically, people don't even need to sit near an infected individual to be exposed. Touching contaminated surfaces such as door handles, window covers, and faucets and then later touching a mucous membrane (eyes, etc.), can lead to inadvertent exposure. This is why quarantine during an influenza pandemic won't work. Quarantine involves separating out healthy people who have been potentially exposed to the illness. For influenza, people can be exposed and not know it.

So what should be done?

At the individual level, people who are sick with contagious respiratory illnesses shouldn't fly. That, of course, is easier said than done--as evidenced by the recent tuberculosis crisis, which illustrates why we are so dependent on a strong public health system, universal access to primary care, and people's consciences--their sense of responsibility to themselves and others.

The Atlanta lawyer was diagnosed with tuberculosis only after receiving a chest X-ray for an unrelated reason. What if he never had the chest X-ray? How many people might he have infected if he hadn't been diagnosed until the disease was much more advanced? Tuberculosis can be transmitted by talking and sneezing. There is considerable debate as to who was responsible in overseeing his case, but clearly public health dropped the ball. (It worked, just not well.)

People flying with upper respiratory tract infections who cough and sneeze could be offered face masks out of courtesy to fellow passengers. Aircraft could keep a supply of them on board for this purpose. I used to keep a little bottle of 60 percent alcohol-based hand gel in my purse for flights until a crack down on security prohibited carrying bottles of liquids and gels on board. I would squirt a glob into my hand and rub my hands together vigorously after touching bathroom door handles or window shades. Airlines could offer such gels to passengers--especially since not everyone washes their hands regularly.

At a national level, nations have an obligation to make sure that their citizens don't spread disease. International travelers should be required to show proof of vaccination against diseases such as measles, mumps, rubella, diphtheria, and pertussis, and proof of a negative tuberculosis skin test (or documentation of noninfectiousness in the event of a positive skin test) when applying for passports. People who travel frequently to high-risk areas should be required to document yearly tuberculosis skin tests before flying.

Millions of people fly annually. Unfortunately, air travel provides a vehicle for pathogens to travel as well. We will assume that most people inadvertently spread their germs, although deliberate spread is always a distinct possibility nowadays. With a global economy, we need to ensure that air travel is safe; to do that, individuals, airlines, and nations must work together to make sure that pathogens do not terrorize airline passengers.
 

JPD

Inactive
DHS Plagued By Turnover In Top Positions

http://www.washingtonpost.com/wp-dyn/content/article/2007/07/15/AR2007071500501.html

The leadership losses reflect "enormous challenges" facing the department four years after its March 2003 merger of 22 agencies, with "serious consequences for the security of our country," according to congressional auditors.

A copy of the study, to be published as early as today, was released by the House Homeland Security Committee.

"It is no wonder that this department is struggling with its integration when its own headquarters has lost half of its senior staff to turnover," committee Chairman Bennie Thompson (D-Miss.) said. "When senior leadership doesn't stick around long enough for their coffee to get cold, the nation's security suffers."

Speaking last Tuesday to a group of lobbyists and business leaders hosted by the Cohen Group, Deputy Secretary Michael P. Jackson said the department is building an effective leadership team. It is understandable that most of 26 senior appointees would change when Michael Chertoff took over from Tom Ridge in early 2005, Jackson noted.

"We're two years into a turnover of that magnitude," Jackson said. "What you're seeing is you have a challenge. At the political level the team is there and working. At the career level, we're working on a succession plan" that will have top staffers cross-trained and able to take over top roles across agencies by January 2009, when a new president takes charge.

The draft GAO report noted that personnel at most Homeland Security components said that filling top positions was either not a problem or only a slight to moderate problem.

Overall, the department reported a leadership attrition rate of 15 percent in 2005 and 13 percent in 2006. Among all workers, the Transportation Security Administration lost 18 percent of airport screeners in 2005 and 15 percent in 2006. Not counting screeners, the DHS lost 3 percent of workers -- less than the federal average of 4 percent.
 

JPD

Inactive
WHO advances plans for bird flu vaccine stockpile

http://www.pharmatimes.com/WorldNews/ViewArticle.aspx?id=11292

16/07/2007

The World Health Organisation has moved ahead with its plans to create a global stockpile of vaccine for the H5N1 avian influenza virus, following agreement by GlaxoSmithKline, Omnivest of Hungary, Baxter and sanofi pasteur to make some of their H5N1 vaccine available.

“This is anther significant step towards creating a global resource to help the world and especially to help developing countries in case of a major outbreak of H5N1 avian influenza,” said WHO Director-General, Dr Margaret Chan.

Operational planning for the stockpile, including how and under which conditions it will be deployed, as well as regulatory aspects of the vaccine, is still to be finalised.

The WHO is also taking other precautionary measures to prepare for a potential influenza pandemic including: rapid containment plans to stop a pandemic using public health measures – such as isolation, quarantine of contacts, personal hygiene and social distancing – and antivirals; and assistance to countries to increase vaccine production capacity, in particular in the areas of research and promoting technology transfer to developing countries.
 

JPD

Inactive
Dialling down immune response to bird flu won't protect against death: study

http://www.mytelus.com/ncp_news/article.en.do?pn=canada&articleID=2722724

TORONTO (CP) - New research suggests successful treatment of the H5N1 avian flu virus requires targeting the virus, not the overwhelming immune response it triggers.

The study, done in mice genetically engineered to lack critical immune system chemicals called cytokines, found these mice were as likely to die from H5N1 infection as mice armed with an intact immune system.

That suggests the activity of the virus, not the immune response it induces, is the main driver of the disease process, said the authors, from St. Jude Children's Research Hospital in Memphis, Tenn.

As such, it is evidence that a phenomenon known as a "cytokine storm" - a massive and cascading production of immune system chemicals that actually damages the host it is meant to protect - is not responsible for the astonishing death rates seen in H5N1 infections.

"These results refute the popular paradigm that the cytokine storm is the cause of death during H5N1 infection," said the researchers, led by influenza guru Dr. Robert Webster.

Dr. Menno de Jong, who has treated H5N1 patients in Vietnam, concurred with the findings, which were published Monday in the journal Proceedings of the National Academy of Sciences.

"This is a viral disease and you should treat with antivirals," de Jong, who is based at Oxford University's Hospital for Tropical Diseases in Ho Chi Minh City, said in an interview from Amsterdam.

"That's the cause of the disease."

The severity of illness caused by the H5N1 virus - which has killed 60 per cent of the people known to have been infected with it - has led some in the scientific community to hypothesize that infection actually triggers a cytokine storm in these patients.

That in turn has prompted scientists to explore the possibility of treating H5N1 infections with drugs meant to tamp down the immune response - things like cholesterol-lowering statin drugs and even some immune suppressing chemotherapy drugs.

But others, like de Jong, have argued that the high cytokine production seen in H5N1 disease may instead be a reflection of the fact that the virus replicates to higher levels and for longer periods than is seen with regular flu strains. If that's the case, they say, tinkering with the immune response could actually allow the virus to do worse damage.

"If you would have a patient with H5N1 infection and the virus damages the lungs by itself, and you would give them an immuno-suppressant treatment, that would give the virus the liberty to just go ahead and replicate," de Jong said.

"Somewhere in the course of disease the immune response certainly can give some additional damage. And maybe cytokines are important for that.... But this is a very virulent virus by itself."

The St. Jude scientists tested the cytokine storm theory in mice bred to be lacking the ability to produce one of three cytokines thought to be critical to the cytokine storm response.

The three groups of genetically engineered mice were then exposed to H5N1 virus. Unmodified mice were also exposed so the response could be compared. In each case the death rates of the modified mice and the regular mice were similar.

"These results demonstrate that inhibition of the cytokine response to infection with highly pathogenic H5N1 influenza virus is not sufficient to protect mammalian hosts from death," the authors said.
 

JPD

Inactive
Togo receives 1 million doses of bird flu vaccine

http://www.afriquenligne.fr/news/da...llion_doses_of_bird_flu_vaccine_200707162875/

The International Office of Epizooties (IOE) has offered Togo one million doses of avian influenza vaccine following the confirmation of an outbreak of the disease in southern Togo, APA learnt on Monday.

Last June, 2, 505 birds allegedly died of the disease in a farm in Sigbehoue, 40 km east of Lome, the capital of Togo.

As a safety measure, a technical team of the ministry for Agriculture, Breeding and Fishing killed the remaining 3,069 birds.

The Mali-based IOE regional office has since May 2006 offered 14 million doses to Egypt, 1 million to Mali, 2 million to Mauritania and Ghana, 1 million to Senegal
 

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Inactive
Bird flu antibodies found in migrant birds in Siberia

http://en.rian.ru/russia/20070717/69083326.html

17/ 07/ 2007

NOVOSIBIRSK, July 17 (RIA Novosti) - Experts have discovered bird flu antibodies in migrant birds in five Siberian regions, a spokesman for the local veterinary regulator said Tuesday.

"Out of over 4,000 samples taken in the area this year, samples from 50 wild birds were found to contain genetic material of the A-H5 virus and antibodies in their blood serum," the spokesman said.

The spokesman said the presence of antibodies meant that either the birds had survived avian influenza, or remained infected but it had not spread in an open form, and could be transmitted to other birds.

He said no local bird flu cases had been registered this year. "About 6 million poultry are currently in high risk areas. Nearly 4.6 million of them have been vaccinated and over 2.3 million revaccinated," he said.
 

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Inactive
Precautions Taken in Virginia to Guard Against Potential Avian Influenza

http://carolina-virginiafarmer.com/index.aspx?ascxid=fpStory&fpsid=29174&fpstid=2

Richard Davis rdavis@farmprogress.com
July 17, 2007

Routine testing of turkeys prior to slaughter has turned up antibodies for avian influenza in Virginia. As a result, state veterinarian Richard Wilkes has canceled public sales, shows and exhibitions of poultry in the Commonwealth.

Wilkes has also temporarily banned the land application of poultry litter, manure or bedding that has been removed from poultry houses in any of 17 Virginia counties.

The test results leading to the actions were found in a flock of turkeys in Shenandoah County. The statewide cancellation of the shows and sales will remain in effect until July 30, 2007, unless Wilkes extends it.

The actions will give the Virginia Department of Agriculture and Consumer Services the opportunity to determine if AI is a threat to flocks on Virginia farms. Avian influenza is not harmful to humans but people can spread the poultry disease. It can be spread by any number of bird species, including domestic poultry, game fowl and others.

"The turkeys did not show any signs of illness prior to testing and the presence of A.I. antibodies does not pose a health risk to humans or other birds," Wilkes said in a formal statement. "The state, along with the poultry industry, is closely monitoring all poultry operations within a six-mile radius of the affected farm.

Learn more at www.vdacs.virginia.gov/animals/avian.shtml.
 

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Inactive
JPD......did you ever read what kind of LP bird flu the turkeys had in Virginia? Was it LP H5N1 ?

U.S. confirms low-risk bird flu in Virginia turkeys

http://www.reuters.com/article/domesticNews/idUSN1128361120070712

Wed Jul 11, 2007 10:22PM EDT

WASHINGTON (Reuters) - Turkeys at a farm in Virginia had antibodies to a low-risk strain of bird flu but direct evidence of infection has not been found, the U.S. Department of Agriculture said on Wednesday.

None of the birds became ill but 54,000 were being slaughtered as a precaution, said Dr. John Clifford of USDA's National Veterinary Services Laboratories.

The turkeys had antibodies to a low pathogenic form of the H5N1 avian influenza virus, Clifford said. This strain of H5N1 does not usually make birds ill, although it could potentially change into a more dangerous form if allowed to spread.

"Every indication is that the virus detected is consistent with the North American strain of low pathogenic H5N1, which is not a human health concern," Clifford said in a statement.

"The turkeys showed no signs of illness, and there was no mortality. Thus far, there is no evidence the virus is actually present in the samples collected. The testing detected only antibodies, which indicate possible past exposure to the virus."

Officials around the world are monitoring birds for all forms of avian influenza. The highly pathogenic H5N1 strain is the cause of greatest worry because of its occasional deadly spread to people.

It has been found in 59 countries in Asia, Europe and Africa but has yet to be detected in the Americas. It is deadly to chickens and sometimes infects people.

H5N1 has killed 192 of the 318 people known to have been infected, according to the World Health Organization.

According to the world animal health organization OIE, outbreaks of highly pathogenic avian influenza have been reported in birds in France, Germany, Bangladesh, and Vietnam this month. Malaysia, the Czech Republic and Togo have also been fighting outbreaks.
 

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Liquidation of hotbed of bird flu in east Bohemia to take longer

http://www.ceskenoviny.cz/news/index_view.php?id=262482

Chocen- The liquidation of the hotbed of bird flu outbreaks in east Bohemia will take longer than expected, deputy head of the Pardubice Regional Firefighter and Rescue corps Ales Cernohorsky said.

The works will probably last till the end of July although previously the culling and the liquidation of birds in the afflicted areas was expected to be completed on Wednesday or Thursday.

"The works have got stuck in Kosorin as it is a large poultry farm of nine units occupying the area of 900 square metres. I have information from the spot that the works will take another 15 days to complete," Cernohorsky said.

The works in Kosorin have been complicated, apart from the large area, also by a great amount of technology," he said.

The works at the farm in Netreby will be completed on Friday.

In all, 199,334 birds have been culled at the poultry farms in Tisova, Norin, Chocen, Netreby, Zarecka Lhota and Loucky that were hit by the H5N1 bird flu virus strain.

Among the poultry liquidated there were ill and healthy turkeys, broilers and laying hens. In addition, 1868 birds from small private flocks have been culled on the orders by vets, State Veterinary Administration spokesman Josef Duben told CTK today.

The first outbreak of bird flu was registered by vets at a farm of 6,000 turkeys at Tisova on June 20. One week later, the virus was discovered at a broiler farm in Norin, four kilometres from Tisova. Other cases of the emergence of H5N1 strain were confirmed at the poultry farms in Netreby and near Kosorin on July 11.
 

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National Strategy for Pandemic Influenza Implementation Plan One Year Summary

http://www.whitehouse.gov/homeland/pandemic-influenza-oneyear.html

Table of Contents

* Executive Summary
* Introduction
* Limiting the International Spread of a Pandemic
* Limiting the Domestic Spread of a Pandemic and Mitigating Disease, Suffering, and Death
* Sustaining Infrastructure and Mitigating Impact to the Economy and the Functioning of Society During a Pandemic
* Looking Ahead: What Have We Learned Through These Efforts and What Gaps Still Need to Be Addressed?
* Acknowledgements

Read at site or download:

PDF: http://www.whitehouse.gov/homeland/nspi_oneyear.pdf
 

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Inactive
One-fifth of country populations could catch pandemic flu: WHO

http://www.physorg.com/news103875344.html

About 20 percent of the population in some countries could be affected in the event of a global flu pandemic, World Health Organisation chief Margaret Chan said Tuesday.

"From experience we do know that what we call the attack rate of a new pandemic would range -- based on past experience it does not necessarily apply for the next pandemic -- (to) roughly 20 percent or thereabout," Chan told journalists.

"If there's a ten million population, with 20 percent, two million would be affected at different stages. And then the severity of the disease would range from mild to severe," she added.

Scientists fear that the H5N1 bird flu virus currently affecting parts of Asia and the Middle East could mutate into a more virulent form that spreads easily among humans, leading to a global pandemic with the potential to kill millions.

The WHO's Director General warned that all people were susceptible and that no country was going to be fully prepared.

However, nearly all the 193 member nations of the WHO now benefit from some degree of preparation to tackle a pandemic, compared to about 50 two years ago, she added.

Chan also underlined the importance of exchanging information on influenza, saying it might offer an opportunity to stifle an emerging pandemic.

"We've never tried that in history. We may be seeing a pandemic unfolding in front of our eyes. So it is incumbent on all of us to try our very best to catch it as early as possible and to nip it in the bud."

The WHO has recorded 318 cases of bird flu in humans, of which 192 resulted in deaths, according to last tally on July 11.

Indonesia tops that list of affected countries this year with 27 cases and 23 deaths, followed by Egypt with 19 cases and five deaths.
 

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Vietnam curbing bird flu

http://english.vietnamnet.vn/social/2007/07/719829/

16:34' 18/07/2007 (GMT+7)

VietNamNet Bridge – The bird flu epidemic in northern Vietnam has been controlled, said Hoang Van Nam, Vice Head of the Veterinary Agency under the Ministry of Agriculture and Rural Development.

Last week, no new site with the disease was detected in bird-flu hit provinces. Only in Dien Bien province were new places with the disease reported on July 16. Around 6,200 fowls have been culled in five communes of Dien Bien district so far.

At present, Vietnam has five provinces with bird flu: Bac Giang, Thai Binh, Ninh Binh and Dien Bien in the north and Ca Mau in the south.

According to Mr. Nam, the bird-flu virus has widely spread in the environment and the disease can break out again any time in any province if local agencies neglect prevention measures.

Tony Forman, an expert of the United Nations Food and Agriculture Organisation (FAO), said that to effectively prevent the epidemic, Vietnam needed to do the following tasks: All ducks must be vaccinated; poultry breeders must strictly obey rules on vaccination; water birds must be monitored from hatching to transport and sale.

FAO also supports recent tough measures of the Vietnamese government to combat the disease, for example closing down water bird hatching farms that don’t meet standards and culling unvaccinated poultry.
 

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Inactive
U.K. Can Control Bird Flu Outbreaks, Scientist Panel Says

http://www.bloomberg.com/apps/news?pid=20601102&sid=a3IFBkAaRcqQ&refer=uk

By Nicholas Comfort and Angela Cullen

July 18 (Bloomberg) -- The U.K.'s current plans to protect against avian influenza are sufficient to control a possible spread of the disease amongst the country's poultry, a panel of scientists from Imperial College London said.

Measures in place to restrict the movement of poultry in the event of an outbreak at as many as 20 farms would contain the spread, the panel said in a summary of the report, which was published today. Disease at a higher number of sites would require more intense control measures, such as culling, the scientists said.

The U.K. successfully controlled an outbreak of bird flu earlier this year by slaughtering about 150,000 birds at a Bernard Matthews Holdings Ltd. poultry plant. The U.K. authorities still could learn from countries such as Germany, where 250 birds have died of the lethal H5N1 strain of avian flu this year, or the Netherlands, which hasn't reported any H5N1 infections, said John Oxford, a professor of virology at St. Bartholomew's hospital in London.

``We're sitting around with our thumbs crossed, hoping that nothing's going to happen,'' Oxford said in a telephone interview. ``There's a lot of planning at the top end, but there is weakness encroaching in the public; people are wondering `Where is this virus then?'''

Abattoirs where poultry stocks are killed before the meat is prepared for human consumption are lightning rods for a spread of the disease, according to the panel.

Industrial Network

``We didn't know how strong the connections in the industrial network would be,'' said James Truscott, the corresponding author of the paper and a research associate at Imperial College's Division of Epidemiology, Public Health and Primary Care, in a telephone interview. ``The 10 to 15 largest poultry companies are most strongly linked through their abattoirs.''

Thousands of birds mingle in the slaughterhouses, and one infected animal can carry millions of H5N1 viruses, Oxford said.

``The virus can stay in a facility for up to a week and be carried as easily as a scent,'' he said.

In the case of infection, both the U.K. Department for Environment, Food and Regional Affairs and the European Commission require an immediate quarantine radius of 3 kilometers (2 miles) and a further observation radius of 10 kilometers.

Methods for containing the spread of the virus to domestic and poultry stocks in Germany depend on keeping birds in their pens in any areas deemed to be exposed to danger factors, such as lakes or clearings where wild fowl carrying the disease flock, said Elke Rheinking, a spokeswoman for the Friedrich Loeffler Institute, an animal health center.

Wild Birds

This year, the German state of Saxony declared an epidemic among black crested grebes, a species of wild bird. The only case of a domestic or poultry infection was a single goose in the neighboring state of Thuringia.

The most important aspect of containment is the work done in the 10-kilometer observation radius around an infected location, Rheinking said.

``If we observe carefully we can call for confinement as soon as the first signs of risk are manifested,'' she said.

Last year, a larger number of infections were found across Germany. Their number decreased throughout summer, and no infections were found by the end of the season.

``We hope the same will be true for this year, but we just don't know,'' Rheinking said.
 

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WHO chief urges governments to improve preparedness for pandemic influenza

http://english.people.com.cn/90001/90782/6217880.html

7:23, July 18, 2007

The threat of a pandemic influenza has not diminished and the world must keep improving their preparedness for any possible outbreak, chief of the World Health Organization (WHO) Dr Margaret Chan said on Tuesday.

"No country is fully prepared for a pandemic. I'm saying this because I'm just being realistic," Chan told reporters at a news briefing in Geneva.

Chan said almost all member states of the WHO now have some sort of pandemic preparedness plan, but some of those plans are not robust and detailed enough.

She said a preparedness plan should not be just a health sector plan and it needs to involve other sectors such as transportation, communication, education, etc..

According to the world health chief, the H5N1 avian influenza is still very much an animal disease and it has been confined to the animal sector.

But there is still of risk of human health and the WHO still receives from time to time reports of human cases from different countries, she said.

Since 2003, the WHO has confirmed a total of 318 human cases of H5N1 influenza, with 192 deaths.

Chan also urged countries to continue sharing avian flu virus with the WHO so that any initial evolution of the virus could be detected.

"The sharing of virus will enable us to characterize the virus - - whether it has acquired changes that would give the virus the potential to cause human transmission in an efficient manner," Chan said.
 

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U.S. making slow progress preparing for flu outbreak

http://www.mercurynews.com/lifestyle/ci_6401697

New York Times
Article Launched: 07/18/2007 01:32:05 AM PDT

WASHINGTON - More than a year after President Bush unveiled a plan for coping with a pandemic flu outbreak, the federal government still has limited capacity to detect a disease outbreak and track its progress across the country.

The government has also decided that it will not close the borders if a pandemic flu outbreak occurs somewhere in the world.

Sealing the border is impractical, said Dr. Rajeev Venkayya, special assistant to the president for biodefense. He said a pandemic virus would eventually make its way to the United States, anyway.

The government will try to limit the number of arriving people who might be infected, Venkayya said. But it will also try to allow the flow of goods and people across the border to continue, he said.

In the coming weeks, officials will release the government's priority list detailing who will get the first lots of flu vaccines in the event of an outbreak. Plans to coordinate with state and local governments about when to close schools are also still in the works.

These updates were delivered Tuesday in a White House briefing on the government's progress in planning for a pandemic flu outbreak.
 

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Inactive
Non-pathogenic strain of bird flu virus found, could turn pathogenic

http://www.kanglaonline.com/index.php?template=headline&newsid=38633&typeid=1

The Imphal Free Press

IMPHAL, Jul 17: The existence of a non-pathogenic strain of the virus causing bird flu has been confirmed in the state according to knowledgeable sources, although state officials are tightlipped about the whole affair, obviously fearing unnecessary public panic.

The officials only said that no pathogenic strain of the virus has detected yet, but were mum about the presence of a non-pathogenic strain.

However the arrival of officials of the Union ministry of veterinary and animal husbandry following the testing of some samples of blood of chickens which died in an unknown epidemic recently in and around Imphal at the High Security Animal Disease Laboratory, Bhopal, raised suspicion of something serious.

Surveillance of more blood samples of chickens have also intensified ever since and continued throughout the day today.

Although the strain found in dead chickens in Imphal recently is not the pathogenic variety, knowledgeable sources said it only takes for the virus to mutate to become pathogenic, hence the need for extreme precautions.

Moreover, they also said the gestation period for the virus to become malignant can be as long as four to five months, hence if full blown bird flu epidemic breaks out five months later, it may be difficult to make the connection with its actual source that existed five months earlier.

Perhaps fearing causing unnecessary alarm, even the state medical department has not been confided with the development.

Surveillance and sera sample collection to test and confirm the geographical spread of the bird flu virus in the state has been intensified in Manipur even as authorities here said "there is no confirm report of outbreak of Pathogenic Avian Influenza (bird flu) in the state."

They however were guarded about the detection of the non-pathogenic strain of the virus.

The surveillance acquired urgency following reports of death of chickens and other animals in various farms in the state.

In the previous week itself, sera sample collected from various places were sent to the High Security Animal Disease Laboratory, Bhopal for detection of avian influenza. The samples were collected from places of the state where there were reports of death of chicken and other farm animals which could have been caused by avian virus, the source said.

The first sample was sent on July 11 last while the second sample was sent Monday (July 16) and the results of both are yet to be received by the state authorities.

Director, Dr Th Dorendra Singh of the state veterinary department, in a brief talked with IFP, said the surveillance and sample collection which has been concentrated in 5km radius around Imphal in the last few days will expanded to 15 km and beyond.

Taking advantage of the interaction, he appealed the people to report of any unusual death of the chicken, birds and other domestic animals. He said it will not only help the officials of his department to collect sera samples for test and to free the doubts in the minds of the people.

He also observed that the masses need to refrain from spreading rumours of the prevalence of the diseases, and at the same time, to prevent the spreading of the disease if it does exist in the state as the virus is risky to human being too.

The current cause of death of chickens could have been of any bird disease as there are so many other diseases with similar symptoms as bird flu.

So one must not hesitate to consult with the experts for confirming the cause of death of birds and animal, he added.

"If there is confirm report of outbreak of Pathogenic Avian Influenza (bird flu) in the state, the state government as well as the Central government will do everything necessary without a moment`s delay to have the epidemic declared by the Union government, the director said.

The prevalence of such an epidemic can be done only by the Union government, he said.

Concerned union ministry following the finding of the sera sample sent to the laboratory will declare the spreading of disease in the state through the state chief secretary along with the immediate steps to be taken up to check its spread, he observed.

The Centre will not delay declaring this if avian virus is indeed detected, he added.

Since, reports of outbreak of bird flu cases in neighbouring Myanmar in March this year, the state veterinary and forestry departments had taken up special precautionary measures to prevent any possibility of the disease spreading into Manipur.

State level as well as district level monitoring cells were opened throughout the state jointly by the state veterinary and animal husbandry, forest and health departments.

The monitoring cells were opened as the Manipur government received direction from the Centre to speed up monitoring the spread of the dreaded disease in the state.

The funds to be incurred in the surveillance and sera sample collection were also to be borne by the Central authority.

Manipur government has already received a fund amounting to Rs. 96.54 lakhs as `Assistance to the states for Control of Animal diseases (Animal Disease Control)` as first installment.

The concerned state authority is also estimated Rs. 30 lakhs as the require amount for expenditure on routine collection of sera for surveillance works against Avian influenza, purchase of works against Avian influenza, purchase of PPE and disinfectants, training of officers and RRTs, awareness camps on avian influenza, publication of leaflet, pamphlet, posters, etc.

Mention may be made that outbreak of Pathogenic Avian Influenza (bird flu) at a farm located in Mayangone sub-district, of Yangon (West) district in Rangoon province on February 28 this year.

In the wake of the report and following instruction from B Bandhopadya, commissioner in the Union ministry of agriculture and cooperation, the state chief secretary to initiated immediate precautionary measures by restricting transport of poultry into Moreh town from Myanmar side.

Apart from this, the Army, BSF and other paramilitary forces, and police and administrators of different districts have been maintaining an alert in their respective areas of jurisdiction.

The state authorities were also sending sera sample regularly to various related laboratories outside the state for testing.
 

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Bangladesh: World Bank Supports Efforts to Combat Avian Flu

http://web.worldbank.org/WBSITE/EXT...agePK:34370~piPK:34424~theSitePK:4607,00.html

WASHINGTON, 18 July, 2007 — The World Bank has approved a US$16 million credit for Bangladesh from the International Development Association (IDA), the Bank’s concessionary arm, to support the Government’s efforts to minimize the hreat and risk of Highly Pathogenic Avian Influenza (HPAI).

This Avian Influenza Preparedness and Response Project is designed to control such infections in domestic poultry, and prepare for, controlling, and responding to possible human infections, especially an influenza epidemic and related emergencies. This will be achieved through three types of interventions: prevention, preparedness and planning, and response and containment.

Bangladesh is a high-risk country for HPAI. Some 50 percent of the national poultry flock of 185 million is backyard poultry, with minimal bio-security. It also has a large duck population of 37 million. In addition, the country is visited annually in the winter months by 21 species of migratory birds that can carry the virus. In fact, Bangladesh has continued to experience outbreaks of the H5N1 virus since February 2007.

“Now that outbreaks have taken place, steps need to be taken urgently to prepare for more such outbreaks in the future,” said Mohamed Toure, World Bank Acting Country Director for Bangladesh. “This project will not only help curb the threat of avian flu but also contribute to the control of other types of infectious diseases, in terms of building overall response capacity in the country.”

The project focuses on three broad areas: animal health, public awareness and information, and implementation support and monitoring and evaluation. “Communication is extremely important to minimize negative consequences of HPAI on poultry production, consumption, and human health and has to be well adapted to the Bangladeshi conditions,” said Mohinder Mudahar, Consultant to the World Bank and co-project team leader.

The project supports the Government’s National Avian Influenza and Pandemic Influenza Preparedness and Response Plan, which provides a strategic national framework to control and contain any HPAI outbreak.

“Immediate action in areas such as improved national surveillance and diagnosis and stock piling of emergency supplies is needed, but there is also a long-term agenda,” said Mr. Mudahar. “Given systemic shortcomings in veterinary services, we need to focus on staff training and improvements in surveillance, diagnostic and curative facilities.”

The project will also be co-financed initially by a US$2 million grant from the Avian and Human Influenza (AHI) Facility, which is administered by the World Bank and supported by nine donors, including the European Commission.
 

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Inactive
India

Manipur alert after 132 fowl deaths

http://www.thestatesman.net/page.news.php?clid=2&theme=&usrsess=1&id=163125

Statesman News Service

IMPHAL, July 18: The unusual death of 132 fowls recently in a private poultry farm here has alarmed Manipur’s veterinary department. It is on alert following reports of the deadly avian flu virus in neighbouring Myanmar and Bangladesh. The department has swung into action, taking precautionary measures. The farm owner and his family members have been administered Tamiflu vaccine. The department has, however, said there is no need to be alarmed.

The department today contacted a veterinary doctor in Pune with samples of anal and nasal swabs taken from the infected fowls for laboratory testing. Two doctors are in New Delhi en route to a high security animal disease laboratory in Bhopal.

The joint commissioner of the Union agriculture ministry in charge of livestock health, Mr AB Negi, said here that an additional 1,000 pieces of N 95 personal protection equipment kit are arriving today.

Mr Negi said until the report arrives from Bhopal, nothing can be concluded. All precautionary measures are being taken to prevent an avian flu outbreak, even if the report turns out to be positive, he said. The flu has hit more than 16 districts in Bangladesh. The porous border is worrying Manipur’s officials. Mr Negi expressed satisfaction with the measures being taken up by the state veterinary and animal husbandry department.

Dr Th Dorendro, director, veterinary department, said 12 fowls that survived the flu have been culled and their blood samples taken for testing. He said field staff are monitoring the area for unusual death of fowls within the 15-km radius of the affected farm. So far, the incident seems to be isolated case. After the outbreak of avian influenza in Bangladesh earlier this year, the Manipur chief secretary on 12 April alerted six departments, including home and health. State, district and sub-divisional level monitoring cells were proposed to be set up.
 

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Pandemic Preparation Boosts Readiness for Other Disasters

http://usinfo.state.gov/xarchives/d...07&m=July&x=20070718125554lcnirellep0.3902094

Annual report of U.S. flu plan identifies preparedness progress, gaps

By Cheryl Pellerin
USINFO Staff Writer

Washington – The United States is better prepared to detect a pandemic flu outbreak, support international work to contain a pandemic in its early stages, limit a pandemic’s spread and save lives after a year of coordinated effort across federal agencies, according to a White House report.

Efforts to strengthen disease surveillance, expand hospital capacity and help the World Health Organization (WHO) improve global access to vaccines remain to be accomplished, the Homeland Security Council found in its one-year review of the National Strategy for Pandemic Influenza implementation plan. (See related article.)

The review, released July 17, comes as WHO reports that the latest human toll from the highly pathogenic strain of avian influenza, H5N1, has reached 318 cases, with 192 deaths. In birds, the outbreak around the world shows no signs of abating. (See related article.)

“Infectious diseases know no borders,” said John Lange, the State Department’s special representative on avian and pandemic influenza, at a July 17 briefing, “and a key aspect of our campaign to contain the spread of highly pathogenic avian influenza and to prepare for the possibility of a human pandemic is large-scale global engagement, specifically ongoing efforts by governments, international organizations and the private sector.”

Lange joined colleagues from the Homeland Security Council, the Department of Health and Human Services, the U.S. Department of Agriculture (USDA) and the Department of Homeland Security to discuss the report.

President Bush announced the U.S. National Strategy in 2005. The implementation plan, released in May 2006, listed more than 300 actions for federal departments and agencies to complete over 12 months. To date, 86 percent is complete and 14 percent is expected to be completed within six months. The actions include domestic and international efforts.

INTERNATIONAL PARTNERSHIP

To confront the threat of a flu pandemic at its source, the United States has made critical contributions to controlling the international spread of H5N1, working with WHO, the U.N. Food and Agriculture Organization, the World Organization for Animal Health and many other international agencies.

Through the International Partnership on Avian and Pandemic Influenza, U.S. experts work with affected countries and international partners to detect, contain and prevent animal outbreaks; reduce human exposure; and enhance planning and preparedness for future outbreaks.

In more than 100 countries, the United States is working on avian flu issues. Over the past year, for example, the U.S. government supported training for more than 129,000 animal health workers and 17,000 human health workers in H5N1 surveillance and outbreak response, and sent 300,000 personal protective equipment kits to 70 countries for surveillance workers and outbreak-response teams.

U.S. experts provided vital technical expertise to national investigations of H5N1 outbreaks in countries on three continents and provided technical assistance, commodities and logistic or financial support to 39 of 60 H5N1-affected countries.

The United States also is working to improve laboratory diagnosis and early-warning networks in 75 countries.

“On the human health front,” said Dr. Rajeev Venkayya, special assistant to the president for biodefense, “we've embarked on a moon-shot approach to re-establishing vaccine production capacity and new technologies such as adjuvants [substances added to drugs to increase their effects], to stretch the effectiveness or the number of individuals we could vaccinate with a single dose of vaccine.” (See related article.)

BIRDS AND BORDERS

Along with partners in other U.S. agencies, USDA scientists are continuing a comprehensive surveillance of wild birds in every North America fly zone and monitoring wild birds in Russia, Greenland and Mexico as an early-warning strategy.

USDA staff members are assigned to rapid assessment and response teams that work in 30 countries, and 130 volunteers are available for international deployments through the FAO or bilaterally between an affected country and the United States.

“We've worked in more than 50 countries to help deliver and disseminate educational materials to prevent the spread of high-path H5N1,” said USDA Chief Veterinary Officer John Clifford. “We have helped train more than 100,000 people in other countries, ranging from animal health workers and wildlife biologists to government policymakers.”

At Homeland Security, Customs Border Protection (CBP) is coordinating with Canada and Mexico to develop, through a series of conferences, guidelines and best practices for law enforcement, emergency medical services, public works and emergency management.

The Transportation Security Administration is leading officials from the CBP, the Centers for Disease Control and Prevention, the State Department, the Defense Department and the Federal Aviation Administration to develop a plan for managing the U.S. commercial aviation system in the event of a pandemic.

Although these steps are designed to address a human flu pandemic, said Dr. Jeff Runge, Department of Homeland Security chief medical officer on pandemic preparedness, “these activities will provide the structure to deal with any other biological threat, whether natural or an instrument of terrorism.”

“If H5N1 were to disappear tomorrow,” said Dr. John Agwunobi, Health and Human Services assistant secretary for health, “the need to be prepared for a pandemic will still exist, and this need to be prepared is something we own as a community, as a society, for the long run.”

The full text of the National Strategy for Pandemic Influenza Implementation Plan one-year summary is available on the White House Web site.

For additional information, see Bird Flu (Avian Influenza).

(USINFO is produced by the Bureau of International Information Programs, U.S. Department of State. Web site: http://usinfo.state.gov)
 

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Avian flu concerns bar live poultry from W.Va. State Fair

http://www.wchstv.com/newsroom/wv/news1.shtml

July 19, 2007 6:10 AM

FAIRLEA, W.Va.
Fairgoers won't see live poultry at this year's State Fair of West Virginia because of concerns about the discovery of avian influenza on a turkey farm in neighboring Virginia.

Department of Agriculture spokesman Buddy Davidson says Agriculture Commissioner Gus Douglass decided to ban live poultry because of the Fairlea event's proximity to Shenandoah County, Virginia, ten miles from the West Virginia border.

On July Ninth, Douglass suspended all poultry shows and sales in West Virginia for 30 days. Davidson says the decision to ban live poultry from the fair, set for August Tenth through August 18th was a precautionary measure.

Douglass has said the low pathogenicity avian influenza found in the turkey flock in Virginia isn't the same as the bird flu found in Southeast Asia, Europe and other countries.
 

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Inactive
Bird flu batters the south; pig disease continues to spread

http://vietnamnews.vnagency.com.vn/showarticle.php?num=01AGR190707

(19-07-2007)

DONG THAP — Bird flu has hit the southern province of Dong Thap for the second time this year, according to Viet Nam’s Animal Health Department.

The province, which was declared free of the virus several weeks ago, reported fresh outbreaks in Tan Hoi Trung Commune in Cao Lanh District, said department officials yesterday.

Tests confirmed the deadly H5N1 strain was responsible for killing 120 chickens on four farms. Local veterinarians have slaughtered the remaining 280 birds and disinfected the sites.

Officials were worried because these chickens were already vaccinated against the virus, said provincial authorities. They are currently conducting an investigation to find out whether the birds were given a faulty vaccine or were perhaps missed.

Another commune in the northern province of Dien Bien also reported a new outbreak of bird flu on Monday, despite the fact the area was not considered a high-risk region, said Hoang Van Nam, deputy head of the department.

Bird flu was responsible for the deaths of 120 ducks in Noong Het Commune, located in Dien Bien District. The remaining ducks were slaughtered and the farm was sprayed to prevent the virus’ return, said department officials.

With fresh outbreaks in Dong Thap, the number of bird flu-infected provinces remains at six, with Nghe An Province the latest removed from the list.

In addition, Bac Giang, Thai Binh and Ca Mau Provinces are also well on their way to clearing their names as they approach the 21-day period without a fresh occurrence of the virus. At a meeting with the National Steering Committee for Avian Flu Control and Prevention on Tuesday in Ha Noi, delegates discussed the importance of vaccinating all poultry.

Tony Forman, the Food and Agriculture Organisation (FAO) representative in the country, said it was an important way to fight bird flu in Viet Nam.

The FAO recommended that poultry farmers comply with department regulations on vaccinating their flocks and closely monitor the illegal trafficking of waterfowl.

The organisation commended the Government for its recent orders to close egg hatcheries and slaughterhouses that fail to meet food safety and sanitation standards.

Pig disease

Almost 100 more pigs died in the central province of Quang Nam from an outbreak of Porcine Reproductive and Respiratory Syndrome (PRRS) on Tuesday. The death toll is now 900 since late June, according to department heads.

The disease, which causes high fevers, respiratory problems as well as constipation and diarrhoea in pigs, has spread to 47 communes. Nearly 18,000 pigs have been infected.

They blame the outbreak on the slow reaction of provincial authorities who reported the problem weeks after it appeared.

"The late notification of the disease and slow reactions by the provincial authorities has caused the outbreak to spread quickly and made the disease difficult to control now," said Bui Quang Anh, the department’s director.

Anh said the Ministry of Agriculture and Rural Development (MARD) had supported the province in the fight against the disease by providing medicines, vaccines and human resources.

To fight the PRRS, the department have asked the province to take urgent measures, including slaughtering critically sick pigs, establishing local quarantine stations, vaccinating healthy pigs, sanitising farms and raising public awareness on the disease to prevent farmers from transporting or selling infected pigs at lower prices.

MARD Minister Cao Duc Phat also sent an official message to cities and provinces nationwide urging communities to make fighting the disease’s spread a priority last Sunday.
 

JPD

Inactive
Avian Flu Ruffling Feathers at 4-H Clubs

http://www.washingtonpost.com/wp-dyn/content/article/2007/07/18/AR2007071802659.html

By Delphine Schrank
Washington Post Staff Writer
Thursday, July 19, 2007; Page B01

The chickens will not be strutting their stuff in Virginia pageants starting today.

Seven hens and roosters gathered for a communal dust bath one recent morning in a Purcellville back yard, shaking and shimmying their feathers into a mound of dry mud, as six members of the Loudoun County 4-H poultry club, ages 4 to 19, sat slumped nearby. With the county fair opening Sunday, the birds should have been in their coops, bracing to have foot feathers fluffed with hair dryers, combs greased with baby oil, and beaks and unruly toenails snipped for inspection at the upcoming show.

A state ban on live poultry sales will prevent Caleb and Gabriella Tilton from taking their prize chickens to the Loudoun County Fair. (By Tracy A. Woodward -- The

But like their brethren that are absent from the Fauquier County Fair that opens today, the Loudoun fowl have been relegated to their back yards by state fiat after an avian influenza scare. The state's action has deflated piles of children in 4-H programs who had spent months of labor and much hard-earned pocket money to turn their charges from scrawny chicks into proud models of purebred excellence. Exhibits and auctions at the fairs were to be the culmination of all that effort.

On July 9, however, the state veterinarian canceled all poultry shows and public sales through July 31 after turkeys at a Shenandoah County commercial farm tested positive for antibodies of a low pathogenic strain of avian flu. Maryland has taken no similar measures.

"This is not a human health concern or a threat to human health at all," said Karen Eggert, a U.S. Department of Agriculture spokeswoman. The department confirmed that the turkeys had been exposed to a North American strain of H5N1 virus, a less-deadly strain than the one that since 2003 has caused the death worldwide of many millions of birds through culling or disease and has killed at least 191 people in Africa and Asia.

None of the turkeys died of the disease or showed any symptoms of illness. The antibodies, a natural resistance, indicate that the birds might have been exposed to the nonlethal North American strain in the past, said Elaine Lidholm of the Virginia Department of Agriculture and Consumer Services. The Shenandoah farm is under quarantine, and 54,000 of its turkeys have been slaughtered. Tests on commercial and backyard flocks in a surrounding 6.2-mile radius have returned negative results, according to agriculture officials.

Japan, Russia, Cuba, Taiwan and Hong Kong have banned Virginia poultry imports, however. And until the state gives the all clear, 4-H members and younger Cloverbuds in Fauquier and Loudoun have opted to replace bird shows and live auctions at their fairs with, respectively, a showmanship contest featuring stuffed chickens and a rubber duck regatta.

"It pretty much stinks," said Caleb Tilton, 10, a new 4-H member who spent the year priming 10 birds for the Loudoun fair. "This was my first year, and now my hopes and dreams are shattered."

But Caleb, who had gathered with club mates at the Purcellville home of club president Carolyn Trent, 15, said he respected the intention behind the ban: to protect his chickens, including Monster Chicken, his beloved black-and-green rooster.

Added vice president Nathan Cironi, 14: "We respect the decision of our health officials; they are looking at what is best for the public. It is hard to understand. . . . But our club teaches us to act unselfishly and do what is best for all."

On a scale of low to high, the disappointment among club members registered as a unanimous "extreme."

It's not just about pageantry, they said. Carolyn said she just broke even last year after recouping $300 in the fair's live auction. Whatever earnings she would have made this year would have gone toward her college savings.

Corn feed prices have skyrocketed, chimed in Laura Gaylord, 17. To cover costs, they'll have to find individual buyers who pay a lot less per head than do participants at the live auction.

"We really do need to sell them. We spent a lot," said Allison Hinke, 16, who, together with her siblings Brandon and Carol, both 14, built summer and winter huts in their home near Leesburg for their first poultry club batch of eight chickens. A goat that Allison was planning to show at the fair died July 5, so the chickens were her last hope.

Meanwhile, at the Fauquier fair, the 450 birds due for exhibition will be featured instead in posters stuck on their original cages, said club leader Briget Kane. Camille Lewandowski, 13, of Warrenton would have brought along 15 birds, including pheasants and ducks.

The seven-year 4-H veteran has a room crammed with East Coast poultry show trophies and ribbons so numerous that they overflow from the walls into two baskets. But, Camille said, even placing second for showmanship in the 2006 poultry show nationals was nothing next to missing the fair, where her friends and fellow 4-H members normally would get to see her prize specimens, including a Japanese Phoenix chicken and its two-foot-long iridescent green plumes.

Camille said she lost count of the dozens of chicks that she had hatched specially for the fair, and she expressed concern about what to do with them. There's barely enough room in her back yard for the 20-odd coops housing all her other feathered critters.

At both fairs, hatching displays that feature incubated eggs, an audience favorite, have also been prohibited. But discussions are underway between club leaders and state officials to secure the right to show eggs, in all their green-and-blue, speckled and chocolate brown varieties.

On another farm near Purcellville, Gabriella Tilton, 8, chased a flock around an open pen, seized her favorite bird, Puff, a baby snow-white Leghorn hybrid, and looked up at her mother.

"Can I show her next year, Mama?" she asked.
 

JPD

Inactive
Ghana: Bird Flu in Ghana

http://allafrica.com/stories/200707190305.html

18 July 2007
Posted to the web 19 July 2007

Cephas Larbi and Lois Beckett
Accra

The Acting Administrator of the United State Agency for International Development (USAID), Henrietta Holsman Fore, and Ghana's Deputy Minister of Food and Agricultural, Anna Nyamekye have visited two Usaid-supported project sites in Accra.

The visit took them to the Veterinary Services Department and the Labadi General Hospital.

The purpose of the visit was to highlight Usaid's contribution to avian influenza (AI) preparedness and outbreak response plan in the country. It was also to reaffirm Usaid's commitment to AI control efforts in the country and showcase Usaid's support for maternal and child health, family planning and malaria prevention.

The Deputy Minister of Food and Agricultural, Anna Nyamekye said the prevention of avian influenza has been very high on the governments' agenda since 2005.

The disease when introduced into any country, especially like Ghana, can have serious socio-economic effects where over 80% of the country's poultry populations of approximately 24million are in the rural areas where they are not kept intensively but scavenge around for their survival.

Farmers need to make sure that they do not accidentally bring the disease from one farm to another by sharing infected equipment-or even by carrying the disease on their feet when they visit another farm.

Ms. Anna Nyamekye said the government is cracking down on the illegal import of chicken and chicken products from other countries. "We arrest and destroy any birds and their products being illegally imported," She said. "Sometimes they enter from the North and come as far as to Accra".

Anna Nyamekye said the Government's attention is now focused on bio-security on poultry farms to prevent the spread of the disease and other poultry diseases from farm to farm.

She commended Usaid and other development partners for their assistance and called on them to continue supporting the country in fighting the disease.

The Acting Usaid Administrator Henrietta Fore with Ghanaian and American health officials at the Veterinary Hospital celebrated the success of workers in containing the spread of the desease in the country.

"Stamping out the disease in the country helps not only Ghanaians but West Africa and the world," said Fore, who is also the U.S. Undersecretary of State and is in the country to participate in the ongoing AGOA Forum.

Since 2005, Usaid has donated nearly U.S.$1 million to Ghana to prevent and combat bird flu, and they a further $300,000 in funding for emergency response will be released this week.

Usaid Ghana, Infection Disease Advisor, Paul Psychas said Bird flu has a devastating effect on poultry and can swiftly wipe out an entire farm. In some countries the virus has also spread to humans, sparking fears that avian influenza might cause a global health crisis.

There have been three bird flu outbreaks reported in Ghana this year, but so far, no humans have contracted the disease.
"Right now it's only a poultry problem, but we want to keep it that way," Paul Psychas said.

American officials have lauded the Ghana's effectiveness in collaborating with international organizations in dealing with the threat. Ghana's government has spent $2.5 million of its own money to deal with the disease and to educate farmers and the public.

"Ghana has been a model in the region," Psychas said.
 

JPD

Inactive
Sanofi flu vaccine plant to triple US production

http://www.reuters.com/article/governmentFilingsNews/idUSN1927223720070719?rpc=401&

By Jon Hurdle

SWIFTWATER, Pa., July 19 (Reuters) - Influenza vaccine maker Sanofi Pasteur (SASY.PA: Quote, Profile, Research) unveiled a factory on Wednesday that will eventually triple its production of the vaccine as U.S. officials seek to boost output amid fears of a pandemic.

The vaccine arm of Sanofi-Aventis is the only U.S.-based producer of injectable flu vaccine. The plant will produce 150 million doses a year after the new 140,000-square-foot (13,000- square-metre) facility comes on line by 2010.

The $150 million facility will also be capable of producing vaccine against pandemic strains of flu. Experts expect a pandemic of influenza of some sort and the No. 1 suspect is the H5N1 avian flu virus, which has so far infected 318 people and killed 192 of them.

In the event of a pandemic, the plant will switch its entire production to that strain, officials told reporters.

"A pandemic would pose a unique challenge," Health and Human Services Secretary Mike Leavitt said. "You can't start planning vaccines (after) a virus appears."

About 70 million of the 120 million flu vaccine doses available on the U.S. market last year were made overseas. U.S. officials fear that in the event of a pandemic, plants might be nationalized by governments eager to protect their own populations.

In 2004, British officials unexpectedly closed a flu vaccine plant because of contamination, cutting in half that season's supply of vaccines for the U.S. market.

Sanofi's increased production is being aided by a $77 million grant for the retooled facility from the federal government. The federal government is spending $1 billion to expand vaccine production over the next five years.

Sanofi produced 50 million doses last year. The rest were made by Novartis (NOVN.VX: Quote, Profile, Research) in Britain and GlaxoSmithKline (GSK.L: Quote, Profile, Research) (GSK.N: Quote, Profile, Research) in Canada. Maryland-based MedImmune, a unit of AstraZeneca (AZN.L: Quote, Profile, Research), makes an inhaled flu vaccine as well.

INCREASING DEMAND

Sanofi anticipates increased demand for seasonal flu vaccine as a result of a stepped-up campaign by federal health authorities to encourage people to get vaccinated. Seasonal flu kills 36,000 people in an average year in the United States.

While the Centers for Disease Control and Prevention said 218 million Americans should get seasonal flu shots, only about 90 million got one last year.

At the new facility in northeast Pennsylvania, vaccine is generated from millions of chicken eggs. In super-clean, climate-controlled rooms, the eggs are inoculated with the virus strain that is identified by international health authorities in February each year.

The virus is then incubated for two to three days, and the eggs then go through a process called candling in which each one is inspected to check that is intact, fertile, and contains clear fluids.

Technicians wearing gowns, masks, gloves and goggles harvest the virus by using machines to decap the eggs and emptying their contents. The resulting fluids are separated and concentrated to produce a clear liquid that is finally made into the vaccine.
 

JPD

Inactive
Bird flu fear in Curonian spit

http://www.baltictimes.com/news/articles/18329/

Jul 20, 2007
From wire reports
KLAIPEDA - Cormorants have started dying on a large scale along the Kaliningrad section of the Curonian spit, it has been reported, sparking fears of an avian influenza outbreak.

According to the Vakaru Eskpresas newspaper in Klaipeda locals fear that if ‘bird flu’ is confirmed as the cause, it could quickly spread into Lithuania.

Russian authorities in Kaliningrad stated this week that the sudden bird deaths will be investigated and that samples will be taken for analysis.

Ornithologist at the Curonian Spit National Park, Gediminas Grazulevicius, said that as yet there are no signs of an outbreak on the Lithuanian side of the border.

“This is the first I have heard of it,” he said, “Maybe these were young birds that just started dying from hunger. Everything is normal on our side. If they did die from bird flu then it is very bad because sick birds could reach Lithuania as well. Our birds also fly to Russia.”

Specialist of the State Public Health Service, Bronius Morkunas, was doubtful about the claims that bird flu was the cause of the deaths. "Usually swans, ducks, and chickens catch bird flu, but not cormorants,” he said.

Even though no cases of bird flu have been registered in Lithuania, veterinarians warn that the threat is real because of the numerous migration paths across the country.
 
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