12/30/06-1/5/07 | Weekly Bird Flu Thread: China Health alert pig farmers die

JPD

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China:Health alert after pig farmers die

http://www.thestandard.com.hk/news_...=35016&sid=11527970&con_type=1&d_str=20061229

Caroline Kim

Friday, December 29, 2006

Health officials are probing the deaths of two local pig farmers who suffered from pneumonic symptoms over the past six months.

As of Thursday evening, the viruses or bacteria that triggered the symptoms had still not been identified despite laboratory tests on the two men.

"Further investigations are needed to ascertain the nature of a possible infectious illness and whether these were in anyway connected to the pigs," Centre for Health Protection consultant Thomas Tsang Ho-fai said Thursday.

"The CHP attaches great importance to the cases and is liaising closely with relevant parties, including the Hospital Authority, the Agriculture, Fisheries and Conservation Department and mainland health authorities."

The two men, a 44-year-old from Sheung Shui and a 62-year-old in Tsuen Wan, had suffered from pneumonic symptoms prior to their deaths on December 13 and June 4, respectively.

The more recent of the two cases was first detected on December 11 when the man was admitted to North District Hospital, only to die two days later.

Health officials were notified of the man's travel history. He went to Dongguan city in Guangdong province about 20 days prior to the onset of the symptoms.

"The CHP has been liaising with the mainland health authorities for exchange of information," Tsang said.

In the earlier case, Tsang said, the Tsuen Wan man suffered from an influenza-like illness before being admitted to Yan Chai Hospital in Tsuen Wan toward the end of May.

Investigations have shown so far that no family members of the Sheung Shui man had suffered from similar symptoms. Officials are still examining the family of the Tsuen Wan patient.

Authorities are also investigating friends, including a pig farmer, who had been visited by the Sheung Shui man early December. The friend has been in hospital with a lung disease and kidney problems.

"We have telephoned local pig farmers and issued them letters reminding them to report any disease outbreaks among the livestock to the AFCD for investigation," a spokesman for the Agriculture, Fisheries and Conservation Department said.

The AFCD also called on farmers to be more sensitive to bio-security measures, including observation of farm hygiene and inoculation of pigs.

The two deaths have sparked concern over a lack of reporting of animal- related diseases in Hong Kong.

"There are loopholes in the communication between the Hospital Authority and the Department of Health that need to be plugged," said Lo Wing-lok, a specialist in infectious diseases.

Lo, who insists any infection related to animals should be reported immediately, drew on previous cases involving diseases transmitted from animals to humans such as AIDS, avian flu and the Ebola and Nipah viruses.

"Most of these animal-related cases are highly infectious and highly fatal," Lo said, adding that close investigation of swine influenza and other possible infections among pigs is necessary to prevent outbreaks.

The time gap between the two cases does not make the risk any less significant, Lo said.

"The world witnessed the first case of avian influenza in April 1997, which then reappeared seven months later in November," he said.

Tsang of the CHP urged pig farmers suffering from pneumonia-like illnesses since June 1 to call a special hotline at 2125 1133 for health-care services.

A meeting between the Health, Welfare and Food Bureau, the Food and Environmental Hygiene Department and the Hospital Authority will be held today to review the cases and to determine what interdepartmental measures may be necessary.
 

JPD

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Vietnamese Family Hospitalized With Possible Bird Flu

http://www.playfuls.com/news_10_6835-Vietnamese-Family-Hospitalized-With-Possible-Bird-Flu.html

Four members of a family in Vietnam's Mekong Delta are being tested for possible avian influenza after being hospitalized with symptoms similar to the disease, a health official said Saturday

Test results would not be available for a week, but if positive for the H5N1 virus, the family would be the first human cases of bird flu in Vietnam for more than a year following a resurgence of the disease in domestic poultry.

The 37-year-old mother and her three sons are in stable condition, according to Dr. To Van Man, director of emergency department of a medical centre in southern Ca Mau province.

"They have been treated in isolation since admission," Man said. "We have treated them with Tamiflu although we are not sure if they have bird flu."

The mother told doctors that her family had eaten a chicken that had died of an unknown disease four days before her oldest son, age 13, fell ill with high fever and trouble breathing. She and her younger sons, ages 7 and 3, became sick soon after.

Vietnam has seen 42 people die of bird flu * which is caught from close contact with sick poultry * since 2003.

The country had driven the disease into remission through an aggressive poultry vaccination programme, but last week officials confirmed it had returned in three provinces including Ca Mau, 250 kilometres south of Ho Chi Minh City

At least 160 people worldwide have died of the H5N1 virus, which has sparked concern for its potential to become into a widespread human disease.

At this moment, the H5N1 virus is not easily contagious among people, but scientists are watching it closely and say that if the virus is left unchecked, it could mutate to allow human-to-human transmission.

If that happened, the new human virus could quickly spread around the world among people who would have no natural immunity. Previous such influenza pandemics have killed up to 40 million people.

There is no human vaccine for H5N1, but poultry can be inoculated and international health experts have recommended trying to contain the virus in poultry so it does not have a chance to adapt to infect humans more easily.
 

JPD

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Central Vietnam facing imminent bird flu threat

http://www.thanhniennews.com/healthy/?catid=8&newsid=23762

About 73 percent of poultry samples came back positive for H5N1 virus in the central province of Quang Nam, reported an official from the Ministry of Agriculture and Rural Development on Friday.

Hoang Van Nam, deputy head of the ministry’s Animal Health Department said the result had put the central region on red alert for bird flu outbreaks.

The seasonal migration of birds and cool weather create a ripe environment for the virus to spread, especially as H5N1 has already been found in poultry, Nam warned.

To date the disease has spread to 10 communes in six districts in three Mekong Delta provinces namely Bac Lieu, Ca Mau and Hau Giang.

Hau Giang’s animal health department said they had quarantined and sterilized infected sites to isolate the outbreak.

Within the last several days in Bac Lieu, relevant agencies had slaughtered thousands of poultry and inoculated another 170,000 fowl.

In Ca Mau and Soc Trang, six people were isolated with bird flu symptoms after eating chicken, and local health centers had taken their samples for tests.

China crisis

Ho Chi Minh City’s market control bureau said illegal poultry trade and transport had increased considerably with 106 cases, more than three-fold those from last week.

In the northern province of Lang Son, poultry trafficking from China was exploding with hundreds of tons of fowl illegally transported into Vietnam daily, which local authorities could not fully control.

Officials said poultry smuggling flared up because domestic fowl prices were rising while smuggled fowl from China was much cheaper.

They added smugglers could benefit substantially from their business, especially in months ahead of the Lunar New Year holiday when fowl demand peaks.

Prime Minister Nguyen Tan Dung assigned 11 relevant ministers to be heads of bird flu control task forces in regions nationwide.

Tran Thi Trung Chien, Health Minister launched Friday a nationwide campaign for January, urging people to sanitize the environment, especially in poultry breeding farms to control the outbreak.

Under the campaign, localities were guided to keep surveillance on poultry trade and transport, especially at border check points.

Local health centers were ordered to prepare medicines for the fight against avian influenza in humans in the event of an outbreak and increase food hygiene inspections.

Since the virus first arrived in Vietnam in late 2003, it has killed 42 of the 93 people infected, second only to Indonesia's 57, according to the World Health Organization (WHO).

WHO said the influenza had killed more than 150 people worldwide since late 2003, and prompted the slaughter of tens of millions of poultry.
 

JPD

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Six suspected bird flu cases in Mekong Delta

http://www.thanhniennews.com/healthy/?catid=8&newsid=23759

Six people were isolated under suspicion of bird flu infection in the Mekong Delta’s Ca Mau and Soc Trang provinces, all of them reportedly had eaten chickens, said local health officials Friday.

Huynh Trung Kien, acting manager of Ca Mau’s health department said the four cases, all in a family in Nam Can district, were hospitalized with symptoms like coughs and high fever after they consumed chickens last week.

The victims were immediately quarantined with their samples submitted to laboratory for testing, Kien said.

Nguyen Huu Minh, deputy head of the animal health department of Soc Trang reported two people in My Tu district had difficulty breathing after eating chicken.

He added bird flu had yet to spread to Soc Trang and the patients had reportedly eaten healthy poultry.

Minh said the results from tests run on the two had not yet been received.

To date, bird flu has resurfaced in 10 Vietnamese communes in six districts in Ca Mau, Bac Lieu and Hau Giang provinces.
 

JPD

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Third case probed after pig farmer deaths

http://www.thestandard.com.hk/news_detail.asp?pp_cat=11&art_id=35088&sid=11541267&con_type=1

Donald Asprey

Saturday, December 30, 2006

Health officials are investigating a third case of pneumonia after the deaths of two local pig farmers.

A 61-year-old male worker at Sheung Shui slaughterhouse has contracted pneumonia but is in stable condition, North District Hospital said.

The latest case comes after the death of two pig farmers, a 44-year-old from Sheung Shui and a 62-year-old from Tsuen Wan, who suffered pneumonic symptoms before they died December 13 and June 4, respectively.

In addition, mainland officials confirmed Thursday the case of a Foshan farmer, 44, who died this month.

A government hotline, meanwhile, has received a call from a 42-year-old male safety supervisor at Sheung Shui slaughterhouse, who said he was hospitalized in North District Hospital for pneumonia in mid-September.

He responded to antibiotics and was discharged from hospital in early November. He apparently had no direct contact with pigs during his work.

Earlier, officials sought to allay the public's fears, stating the unknown illness was neither as contagious as SARS nor as lethal to animals as bird flu.

Centre for Health Prevention consultant Thomas Tsang Ho-fai said the Agriculture, Fisheries and Conservation Department is conducting tests on local pigs, the Hospital Authority enhancing surveillance on local cases of pneumonia and the center manning the hotline for farmers to report any cases of hospitalization.

However, Tsang said identifying the virus or bacteria that triggered the pneumonic symptoms would take at least a month or more, or not at all, adding the cause of 60 percent of pneumonia cases go undiagnosed.

"There is a difference from SARS. The families of the victims were not found to be infected, which suggests the infectious agent is not as contagious as SARS. Also, there have been no reports of pig deaths and in this respect it is unlike avian flu, which kills a large number of chickens," he said.

No connection between any of the farmers, other than they kept pigs, has been found.

"We will have to focus on pig farmers and conduct more investigations as that is the most striking similarity between the cases and the effect on them will be greatest," Tsang said.
 

JPD

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Vietnamese family tests negative for bird flu

http://www.channelnewsasia.com/stories/afp_asiapacific/view/250001/1/.html

Posted: 31 December 2006 1426 hrs

HANOI : A Vietnamese family has tested negative for bird flu, a health official said Sunday, after their hospital admission with respiratory ailments had sparked fears of a resurgence in human infections.

The mother and her three children fell ill a week earlier after eating a chicken that had died on their farm in Ca Mau, one of three southern provinces where the H5N1 strain of the virus has killed poultry this month.

But tests at Ho Chi Minh City's Pasteur Institut found that the family was not infected with the avian influenza virus, which between 2003 and 2005 killed 42 people in Vietnam, said the institute's Dr Phan Van Tu.

"All four people, the mother and her three children from Ca Mau province, on Saturday tested negative for the H5N1 virus," Tu told AFP. "They were suffering normal pneumonia." - AFP/ch
 

JPD

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Jordan on alert for bird flu

http://www.ameinfo.com/106771.html

The Jordanian government is on alert following the latest outbreak of bird flu in Egypt which has claimed three lives over the past week, reported the Jordan Times. Assistant Secretary General of the Ministry of Health Adel Belbeisi said all necessary precautions were being taken and $5.7m worth of tamiflu had been acquired.
 

JPD

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Nigeria

The chicken you must not eat – Expert

http://www.thetidenews.com/article.... you must not eat – Expert&qrColumn=INTERVIEW

Sunday, Dec 31, 2006

More than any other time in the year, the yuletide season is the period when chicken are killed and eaten in very large quantity. And in the face of the ravaging Avian Influenza (Bid Flu) scare still reported around the world, Staff Writer Opaka Dokubo met with Dr. Allwell Emejuru, Secretary, Inter-Ministerial Committee on Bird Flu in Rives State and the Desk Officer (Anima Health) in charge of Rivers State, under the World Bank sponsored Avian Influenza Control Project in Nigeria, in his office in Port Harcourt.

Among others, Dr. Emejuru spoke on cautions to be taken while handling birds generally, the state of affairs in Rivers State concerning the disease and the long awaited compensation to farmers whose birds were culled in the state. Excerpts.

Current situation about bird flu in Rivers

By February this year, we had the incidence of bird flu at Bori Camp Army Barracks. We went to control the situation and exterminated the diseased birds. And you can see that Rivers State is free of Bird flu. So, in this period of Christmas, people can eat their chickens but only watch out for unusual signs like death of a large number of birds (and) call on us and we will respond and to confirm if it is bird flu or not so that we can take appropriate action.

Signs to look out for

The first sign is high mortality in a poultry house. Say some one has about 500 to 1000 birds and about half of them dieing within two days. Of course when that happens, you may be afraid yourself and so you should expose yourself further. You may not know at first but signs should call for caution. The other signs include rending of parts of the body, cough and sudden death. You may even be there watching the birds die in your presence.

The reason we want it to be controlled at the animal level is because if the virus is transferred to human beings, (they) are also likely to die in such large numbers. And that’s why efforts are made to control the disease at the animal level and that also explains why all animals within the infected area are killed or culled to prevent the spread of the virus.

Situation around the world

We’ve heard unconfirmed reports of a case in France and also of somebody dieing of Bird flu in Egypt. However, there has not been any case of human death in Nigeria. It (bird flu) is there and the effort all over the world is to make sure that this disease is controlled. The virus has been with the birds and is jumping to humans. The effort is to make sure that it is restricted to the animal level. But the virus is fighting back and we are trying to suppress it. In Nigeria, there was a report of its resurgence in Lagos State last month but it was controlled as well. We are at alert. The caution we have now is that, this is Winter in Europe and during this period some birds migrate from there to Africa that is warm. That is why we are very alert and also advise that people should watch out for signs, such as sudden death of large number of birds, those that have swollen heads, cough and painted parts of the body.

The problem of bird flu is not in the death of birds. We have several diseases that cause the death of large number of Birds but because this one affects man and has the potential of killing man in large number also, that’s why there’s this global concern for it. It indeed carries the danger of going into a pandemic where a large number of people can die within a very short period of time, so everybody has to be cautious about it.

In this regard, we advise that people should stop sleeping with chickens in the same room. In some villages, women still have some corners where their chickens sleep, while they sleep on the other end. They should stop that. Another thing is that whenever somebody touches chicken, he should wash his hands properly – live chicken particularly. People should not eat any sick chicken at all. People should not take that risk. Previously people quickly slaughtered any chicken they observed to be sick. However, now we advise, since they cannot tell the nature of the sickness, that people should completely stay away from sick or dead chicken.

This virus (avian influenza virus) is still trying to be accustomed to the human body and once that happens, the transferability from man to man becomes easier. So, the more we keep it away from human body, the better for us.

Cooking kills the virus

Cooking kills the virus. In fact the cooked chicken has no problem. Heat destroys the virus. It is in the process of preparation the problem lies. It is the person doing the touching and preparing while it is yet uncooked that runs the danger of breathing in the virus and be infected.

Children also run the risk. They may see a wild bird in their surrounding or where they have them as pets. If the pet is carrying the virus, they can be infected.

Virus infects birds generally

Birds like the water duck is a very good reservoir for this virus but they don’t show the signs. So, while they are roaming about with the virus, they can transfer it to our domestic chickens – which we feel free to touch. That is where the danger lies and that is why you need to watch your hands very well each time you touch any bird. Again even pigs carry the virus without showing any signs and they will not die.

Human vulnerability

This may be in the human constitution. Even up till now, the avian influenza virus is still trying to be fully accustomed to surviving in the human body and the moment it finds it very easy to do this, a pandemic will occur. And that is what we are trying to prevent. At the moment if a human is infected and is not treated within 48 hours, the person stands a very slim chance of survival. That is why when a chicken is infected, we don’t talk only about the diseased chickens, but all chickens, within that area are exterminated. We don’t want to give the virus any chance of getting to humans regularly and then posing such a great danger and that is the concern of the whole world.

Compensation to farmers

Actually it is the programme of the federal government to cull all the infected birds and pay compensation, and actually payment has been made in some sates of the federation. However, the scheme has been taken over by the Avian Influenza Control Project – it is a national project. They have taken over the payment of compensation. The situation is that before January (2007) runs out, affected farmers in Rivers State will be paid.

Under the new programme, however, within three days of the culling of birds, affected farmers will be paid. The delay had been due to the attempt at fashioning out a way of hastening the process of payment and surely after this one, there will be no more delays. Before now, it was done under an ad hoc arrangement but now a proper structure has been put in place and so within three days of the culling of birds, the person will be paid from next year.

We actually appreciate the patience of those whose birds were culled. They should please bear with us. Arrangements are made to make sue that they are paid in January 2007.

Message to public

We don’t have any fear about bird flu in Rivers State, however, if you observe any signs, just call on us and we will take care of it. They should also avoid eating sick or dead chicken. For now, Rivers State is free of bird flu.
 

JPD

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Kenya

Containers sent back over bird flu fears

http://www.eastandard.net/hm_news/news.php?articleid=1143963186

By Mathias Ringa

The Government has ordered importers of four containers loaded with chicken products to re-ship them to their point of origin in an effort to prevent the dreaded bird flu from spreading into the country.

The Coast Provincial Veterinary officials impounded the four containers at the port of Mombasa.

Coast Provincial Veterinary Services director, Mr George Makalo, said the Government would prevail upon the importers of the chicken products to re-ship them back to their point of origin.

Speaking to The Standard on Sunday, Makalo said two of the containers imported from Egypt were impounded by the Veterinary Department and port police in November last year.

Police impounded the remaining two containers imported from Malaysia and Thailand last month.

The veterinary official said the containers should be reshipped to Egypt, Malaysia and Thailand, as they might expose Kenya to the risk of the contagious flu. Police guarded the containers round the clock, he said.

Stringent measures had been put in place to ensure that chicken products imported from countries affected by bird flu were not released to the local market.

Makalo warned local importers against violating a 1999 Government ban on importation of chicken products from affected by the bird flu.
 

JPD

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Vietnam

PM orders resolute bird flu prevention measures

http://www.nhandan.com.vn/english/news/010107/domestic_pm.htm

Prime Minister Nguyen Tan Dung, on December 31, told southern localities to take strong measures to prevent a recurrence of bird flu, especially the vaccination of newly-hatched poultry.

The PM made the request during his meeting with authorities of seven localities in the southern part of the Hau River, including Can Tho city and the provinces of Ca Mau, Bac Lieu, Soc Trang, Hau Giang, Kien Giang and An Giang.

He said the localities have not done well in vaccinating their poultry against bird flu, as outbreaks were discovered among unvaccinated poultry.

The PM criticised the authorities of Ca Mau, Bac Lieu and Hau Giang provinces, where bird flu broke out recently, for lacking vigilance and being late in discovering the epidemic. He insisted that these localities should quickly isolate affected farms and destroy infected poultry to prevent the disease from spreading to humans; strengthen surveillance of poultry farms to detect outbreaks early and intensify disinfections and detoxification of farms.

PM Dung also required the provinces to promote the dissemination of information about bird flu to raise public awareness of the disease.

According to the PM, the Government would provide funds for the seven localities to help them in the fight against bird flu and ask relevant agencies to supply sufficient vaccines for these localities to conduct inoculation for all of their poultry. (VNA)
 

JPD

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Bird flu raging in Vietnam’s Mekong delta

http://www.thanhniennews.com/healthy/?catid=8&newsid=23810

More poultry deaths and infected sites have been reported in Vietnam’s Hau Giang, Ca Mau and Bac Lieu provinces in the last two days.

Nguyen Hien Trung, head of Hau Giang’s animal health department, said a new site had been identified in Vi Thuy district yesterday after a dead bird had tested positive for the deadly H5N1 virus strain.

A total of three communes in two districts had bird flu, he said.

Luong Ngoc Lan, head of Bac Lieu’s department of agriculture and rural development, said more poultry deaths had been reported in Hong Dan, Hoa Binh, Vinh Loi, and Gia Rai districts on Sunday.

The dead birds had tested H5N1 positive in Hong Dan and Hoa Binh while results were awaited from the other two districts, Lan said.

In Ca Mau many poultry reportedly died Monday.

The peidemic has hit at least 13 districts in the three provinces, prompting the slaughter of tens of thousands of fowl. Four people in Bac Lieu and two in Soc Trang provinces have been hospitalized with bird flu symptoms.

Last week Vietnam launched a national anti-bird flu campaign to stamp out the epidemic.

The World Bank has approved a US$10 million grant for a program to combat bird flu.

At least 42 people have died of the H5N1 virus in Vietnam since 2003 with the latest case reported in November 2005.

The disease has killed 157 of the 261 people infected globally since 2003.
 

JPD

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For Travelers: A Review Of The Avian Flu

http://www.medicalnewstoday.com/medicalnews.php?newsid=59893

Though the transmission of the avian bird flu to humans is still considered rare, the threat of a global pandemic is enough for travelers to stay abreast of the latest news. Helping to provide this information is a new article that reviews the avian flu as well as the recommendations for travelers. The article is published in the latest issue of Wilderness and Environmental Medicine.

Avian influenza A (H5N1) is a common organism found in the digestive tracts of mainly aquatic birds worldwide. It typically causes few, if any, problems in wild birds but can cause severe disease and death in domesticated fowl. At least 17 major outbreaks of avian flu strains have resulted in the deaths of millions of birds. The 1997 outbreak in Hong Kong also led to transmission to humans. Since 1997, the World Health Organization sites a reported 218 human cases of avian flu, resulting in 124 deaths.

Human-to-human transmission has not been documented. The mutation of the virus that would make that possible could be devastating on a world scale. At this time, however, the risk factors for contracting the virus are limited to contact with infected birds. Those factors include contact from slaughtering, defeathering, and butchering fowl; close contact with wild birds or caged poultry; ingestion of undercooked poultry products; direct contact with surfaces contaminated with poultry feces; and close contact with infected humans.

Once contracted, the human version of the avian flu resembles typical flu illnesses, with fever and lower respiratory tract symptoms. Often, patients develop rapidly progressive respiratory failure and require a ventilator. Treatment is mostly supportive care with the addition of antiviral medications.

For travelers in countries with both human and avian flu, the risk of developing the disease is low. In fact, there are currently no recommended travel restrictions. If anything, common sense would tell travelers to avoid contact with all birds, especially poultry; avoid surfaces contaminated with poultry feces; and avoid undercooked poultry products. The use of prophylactic antiviral medications is not recommended.
 

JPD

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New AI guidelines issued

http://www.meatnews.com/index.cfm?fuseaction=Article&artNum=13478

ITALY: The World Health Organization (WHO) has developed advice for the use of antiviral treatments for avian influenza.

The World Health Organization (WHO) has developed pharmacological advice for the use of antiviral treatments for highly pathogenic avian influenza in response to a report in the January 2007 issue of The Lancet Infectious Diseases.

Holger J. Schünemann, MD, and colleagues from the WHO Rapid Advice Guideline Panel on Avian Influenza said in the report that, "Despite international agreement to stockpile antivirals, evidence-based guidelines for their use do not exist."

The WHO convened an international panel to develop guidelines for pharmacological treatment of H5N1 patients. The group agreed on a number of strong recommendations relating to treatment of H5N1 patients in a non-pandemic situation.

They say:

• Patients should receive oseltamivir treatment as soon as possible.

• If neuraminidase inhibitors are available, clinicians should not administer amantadine alone as a first-line treatment.

• If neuraminidase inhibitors are available, clinicians should not administer rimantadine alone as a first-line treatment.

• High-risk exposure groups should receive oseltamivir as chemoprophylaxis continuing for 7 to 10 days after the last known exposure.

Web posted: January 2, 2007
 

JPD

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Bird flu hits 25 communes in Mekong Delta provinces

http://english.vietnamnet.vn/social/2007/01/649883/

08:05' 03/01/2007 (GMT+7)

Bird flu has to date stricken 25 communes in 11 districts in the southern provinces of Ca Mau, Bac Lieu and Hau Giang, resulting in the bury of nearly 24,000 poultry.
Soạn: HA 999621 gửi đến 996 để nhận ảnh này

The figures were released by the Veterinary Department under the Ministry of Agriculture and Rural Development at a meeting of the National Steering Committee for Bird Flu Control in Ha Noi on Jan. 2.

The department warned that the disease is likely to reoccur in other areas across the country, particularly northern provinces where the transport and trading of poultry and poultry products of unclear origin have yet to show signs of decrease.

To prevent avian influenza from spreading in the Mekong Delta region, the Ministry of Agriculture and Rural Development has allocated more bird flu vaccines, disinfectant, sprayers and protective equipment to the three affected provinces and high-risk localities.

Meanwhile, the National Steering Committee for Bird Flu Control has asked relevant ministries and agencies to step up efforts to instruct and supervise the implementation of measures to curb avian influenza and flu type H5N1 in humans.
 

JPD

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Bird flu likely to spread to central, northern Vietnam

http://english.people.com.cn/200701/03/eng20070103_337897.html

Bird flu, which has hit Vietnam's three southern provinces since early last month, is likely to strike the central and northern regions, local media reported Wednesday.

The risk of bird flu appearing in the two central provinces of Quang Nam and Quang Ngai, and the three northern localities of Bac Giang, Hai Phong and Thai Binh is apparent, Saigon Liberation newspaper quoted Vietnamese Deputy Minister of Agriculture and Rural Development Bui Ba Bong as saying.

The risk is more obvious in the two central provinces since most of samples from healthy fowls there have been tested positive to bird flu virus strain H5N1, he said at the meeting of the Central Steering Committee for Bird Flu Prevention and Fight on Tuesday, noting that bird flu surveillance systems in some localities are weak, fowl vaccination in a few central provinces is not complete, and illegal poultry trade and smuggling in some localities is rampant.

According to the committee, bird flu has, since December 2005, hit 26 communes in 12 districts in the three provinces of Ca Mau, Bac Lieu and Hau Giang. It has killed some 6,000 poultry, and led to the forced culling of nearly 23,000 others, mainly ducks and chickens.

Amid recent outbreaks, the agriculture ministry is considering the possibility of extending the existing national ban on hatching waterfowls which is to expire on Feb. 28, the newspaper said.

Eleven Vietnamese ministers have been assigned to go to 35 cities and provinces nationwide to offer anti-bird flu directions and inspect relevant activities there. Their trips will last till the end of March.

Bird flu outbreaks, starting in Vietnam in December 2003, have killed and led to the forced culling of dozens of millions of fowls in the country.
 

JPD

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Bird Flu Viruses Unlikely to Endure Water Treatment, Study Says

http://www.bloomberg.com/apps/news?pid=20601103&sid=awkOSNqiviT8&refer=us

By Jason Gale

Jan. 3 (Bloomberg) -- Bird flu viruses are unlikely to survive sewerage and drinking water treatment systems, making it doubtful contaminated feces could infect plant workers and spread through tap water, scientists at Cornell University said.

The researchers studied a low-pathogenic H5N2 avian influenza virus, which they said resembles the lethal H5N1 strain circulating in Asia and Africa. Water treatments, including chlorination, ultraviolet radiation and bacterial digesters killed the microbes, said Araceli Lucio-Forster, a microbiologist at Ithaca, New York-based Cornell.

The finding may reduce concerns about drinking water as a mode of infection during a pandemic. World health officials say the H5N1 flu virus, which has killed 157 people since 2003, may spark a global outbreak if it mutates to become as infectious to humans as seasonal flu.

``You have some 50,000 treatment plants in the U.S., and all these operators that run the plants were concerned that if there were an influenza outbreak and everyone were sick, is it going to come into the plant and infect them and others?'' Dwight Bowman, a professor of parasitology at Cornell and co- author of the study, said yesterday in a prepared statement.

It is unknown if H5N1 is more resistant than H5N2 to procedures used by the water management industry, Lucio-Forster said. H5N2 was used as a surrogate virus because it can be studied in lower-level biosafety facilities, she said.

Given the similarities between the two viruses, if H5N1 entered the water treatment system, ``the virus should be inactivated, which means treated water may not be a likely source of transmission,'' Lucio-Forster said.

Scientists are tracing the pathways by which a pandemic influenza virus could spread to identify potential risks.

SARS Spread

In March 2003, more than 300 people living in Hong Kong's Amoy Gardens housing complex contracted Severe Acute Respiratory Syndrome, or SARS. An investigation showed that the SARS virus could live in diarrhea for as long as six hours and was capable of being spread through a contaminated sewage system and shared communal facilities.

Avian flu viruses don't survive well outside of a host, the Cornell researchers said.

To test the effectiveness of UV radiation for killing the H5N2 virus, they exposed the virus in drinking water as well as in wastewater effluents to UV light at varying levels. The treatment was effective in killing H5N2 at levels well within industry standards and at lower levels than are used for killing Cryptosporidium and Giardia in water, they said.

For chlorine, which is mostly ubiquitous in U.S. drinking water, the results were less definitive from tests undertaken at the U.S. Military Academy at West Point, New York.

On average, U.S. plants treat drinking water with chlorine concentrations of 1 milligram per liter for 237 minutes. Under these conditions, the researchers found that H5N2, and probably H5N1, would be mostly inactivated. Further studies are needed to see if the viruses stay active when they come out of feces or are at different acid and salinity levels, they said.
 

JPD

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New Details On How The Immune System Recognizes Influenza

http://www.medicalnewstoday.com/medicalnews.php?newsid=59936

Drawing upon a massive database established with funds from the National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health (NIH), scientists have completed the most comprehensive analysis to date of published influenza A virus epitopes--the critical sites on the virus that are recognized by the immune system. The findings, reported by researchers at the La Jolla Institute for Allergy and Immunology (LIAI), are being published online this week by the journal Proceedings of the National Academy of Sciences.

The study should help scientists who are designing new vaccines, diagnostics and immune-based therapies against seasonal and pandemic influenza because it reveals in molecular detail exactly where the immune system focuses on the viruses. Although the complete molecular structures of essentially all major strains of influenza viruses are known, immune responses concentrate on limited regions of certain parts of the virus, and these regions must be identified as immune epitopes by research studies. The LIAI team found that while there were hundreds of shared epitopes among different virus strains, including the avian H5N1 virus, only one has been published that appears ideal for multi-strain vaccines. Information on shared protective epitopes is important for developing influenza vaccines that can provide broad protection against multiple strains of the virus.

"This study is interesting for what it shows we know and do not know," says NIAID Director Anthony S. Fauci, M.D. "It reveals many gaps in our knowledge of influenza viruses and indicates where we need to focus our attention."

The analysis drew upon a much larger effort called the Immune Epitope Database and Analysis Resources Program, which began in 2004 after NIAID awarded LIAI a $25 million contract to create a single repository of immune epitopes from critical disease-causing microbes, including agents that might be used in a bioterrorist attack. Influenza epitopes comprise only a portion of the extensive database, which has become the largest single collection of such information anywhere in the world. It includes data from thousands of separate articles published over several decades, providing extensive dossiers on dozens of pathogens.

"The purpose of the database is to provide a catalog of molecules and structures that scientists around the world can quickly access and use to understand the immune response to a variety of epitopes, or methodically predict responses to as-yet untested targets," says Alessandro Sette, Ph.D., who heads the Vaccine Discovery division at LIAI and is the lead investigator on the project.

For the current study, Dr. Sette and his colleagues examined 600 different epitopes from 58 different strains of influenza A virus. One of their main goals was to determine how conserved, or similar, epitopes are between different strains of bird and human influenza viruses. Knowing this is important because the virus rapidly mutates and can swap gene segments between strains, which could increase the ability of an avian virus to be transmissible to humans.

In addition, only a handful of the epitopes are known to be associated with protective immunity. Most of the influenza virus epitopes in the database are those recognized by a type of immune cell known as a T cell; far fewer are recognized by B cells, a type of white blood cell that produces infection-fighting antibodies. Antibodies induced by seasonal and pandemic flu viruses or vaccines are a major component of immunity that protects against these viruses.

Strains of influenza virus can vary enough in their neutralizing B cell epitopes that a vaccine against one strain may not protect against another strain. But if epitopes are conserved between virus strains, the immunity a person has developed towards one strain might provide at least some protection against the other strain.

Using a software tool they developed, the LIAI team found hundreds of conserved influenza virus epitopes in the database, including those between avian H5N1 and strains of human influenza viruses. But what is less clear from the analysis is how cross-reactive an immune response would be to most of these conserved epitopes. Further analyses may assist scientists in identifying vaccine targets that might offer broader protection and in predicting how effective a new vaccine will be.

Other analyses revealed major gaps in scientists' knowledge about influenza viruses. Of the 600 epitopes in the database, for instance, very few were from strains of H5N1 avian influenza. And even though the database contains epitopes from all the influenza virus' proteins, the vast majority of the data relates to just two influenza proteins, the hemagglutinin (HA) and nucleoprotein (NP).

Most of the influenza virus data comes from analyses of immune responses obtained with mice; some comes from rabbits, ferrets and monkeys, and very little comes from humans or birds. In fact, only one antibody epitope came from a human. The LIAI researchers say more studies should be focused on identifying human T and B cell epitopes from human and avian strains of influenza virus--especially those associated with protective immunity.

"The bottom line is that this study shows us where we need to go," says project director Stephen Wilson, Ph.D., chief technology officer at LIAI. "Hundreds of flu epitopes have already been published and are now in the database, but critical gaps become apparent when one looks for human antibody targets."

Plans for the future include adding data on epitopes that are involved in autoimmune diseases and epitopes that trigger allergic and asthmatic reactions. Dr. Sette and his colleagues have also built numerous tools for analyzing and visualizing the data and for predicting immunity against different pathogens--all of which is publicly accessible on their Web site (see http://immuneepitope.org/).

###

NIAID is a component of the National Institutes of Health. NIAID supports basic and applied research to prevent, diagnose and treat infectious diseases such as HIV/AIDS and other sexually transmitted infections, influenza, tuberculosis, malaria and illness from potential agents of bioterrorism. NIAID also supports research on basic immunology, transplantation and immune-related disorders, including autoimmune diseases, asthma and allergies.

The National Institutes of Health (NIH)--The Nation's Medical Research Agency--includes 27 Institutes and Centers and is a component of the U. S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov/.

Reference: H Bui et al. Antibody and T cell epitopes of influenza A virus--knowledge and opportunities. Proceedings of the National Academy of Sciences DOI: 10.1073/pnas.0609330104 (2007).
 

JPD

Inactive
Wild bird tests positive for bird flu in Hong Kong

http://news.monstersandcritics.com/...bird_tests_positive_for_bird_flu_in_Hong_Kong

Jan 4, 2007, 12:40 GMT

Hong Kong - A wild bird found dead in urban Hong Kong has tested positive for the avian flu virus, government officials confirmed Thursday.

The bird, discovered in Causeway Bay on Hong Kong island, is the first this winter to be discovered in Hong Kong with the virus which has killed 157 people mainly in Asia since 2003.

Dr Thomas Sit of the Agriculture, Fisheries and Conservation Department, said tests on the bird revealed it had died of the H5N1 virus and that it could signal the start of the bird flu season in Hong Kong.

'I would suspect, as would many animal health authorities in the world, that migratory birds may be the first to carry the virus and then infect wild birds,' he said.

He said doctors had been asked to watch for possible human cases while his staff would step up monitoring of the wild bird population.
 

JPD

Inactive
China's Chan takes over as WHO chief

http://www.swissinfo.org/eng/intern...Sect=143&sid=7400617&cKey=1167913355000GENEVA

(Reuters) - Chinese bird flu expert Margaret Chan took over as head of the World Health Organisation (WHO) on Thursday and promised to put Africa and women at the top of her agenda.

Chan, the first Chinese to head a United Nations' agency, was chosen as director-general of the 192-state world health body last November in an election prompted by the death in office of her predecessor, Lee Jong-wook of South Korea.

"I want my leadership to be judged by the impact of our work on the health of two populations: women and the people of Africa," Chan said in a statement.

Women were particularly vulnerable to health problems because of the risks they face during pregnancy and childbirth and their low status in some countries, Chan said in a speech to WHO staff.

Africa was not only being ravaged by three big killers -- AIDS, malaria and tuberculosis -- but chronic diseases such as diabetes and heart disease were taking a rising toll.

Chan, 59, most recently the WHO's assistant director-general for communicable diseases, has said that the world needs to reinforce surveillance to ensure that new killer diseases, which she said would continue to emerge, were quickly detected.

The profile of the WHO, which has a two-year budget of $3.3 billion (1.7 billion pounds), has risen with the spread of AIDS and other diseases, and the emergence of new threats such as the respiratory illness SARS and bird flu.

Bird flu, which has ravaged poultry populations in southeast Asia, remains mostly an animal disease.

It has killed more than 150 people since late 2003 and experts fear that if it becomes more easily passed between humans it could trigger a pandemic in which millions of people could die.
 

JPD

Inactive
New Details on How the Immune System Recognizes Influenza

http://www3.niaid.nih.gov/news/newsreleases/2007/NewDetailsImmuneSysFlu.htm

Drawing upon a massive database established with funds from the National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health (NIH), scientists have completed the most comprehensive analysis to date of published influenza A virus epitopes--the critical sites on the virus that are recognized by the immune system. The findings, reported by researchers at the La Jolla Institute for Allergy and Immunology (LIAI), are being published online this week by the journal Proceedings of the National Academy of Sciences.

The study should help scientists who are designing new vaccines, diagnostics and immune-based therapies against seasonal and pandemic influenza because it reveals in molecular detail exactly where the immune system focuses on the viruses. Although the complete molecular structures of essentially all major strains of influenza viruses are known, immune responses concentrate on limited regions of certain parts of the virus, and these regions must be identified as immune epitopes by research studies. The LIAI team found that while there were hundreds of shared epitopes among different virus strains, including the avian H5N1 virus, only one has been published that appears ideal for multi-strain vaccines. Information on shared protective epitopes is important for developing influenza vaccines that can provide broad protection against multiple strains of the virus.

“This study is interesting for what it shows we know and do not know,” says NIAID Director Anthony S. Fauci, M.D. “It reveals many gaps in our knowledge of influenza viruses and indicates where we need to focus our attention.”

The analysis drew upon a much larger effort called the Immune Epitope Database and Analysis Resources Program, which began in 2004 after NIAID awarded LIAI a $25 million contract to create a single repository of immune epitopes from critical disease-causing microbes, including agents that might be used in a bioterrorist attack. Influenza epitopes comprise only a portion of the extensive database, which has become the largest single collection of such information anywhere in the world. It includes data from thousands of separate articles published over several decades, providing extensive dossiers on dozens of pathogens.

“The purpose of the database is to provide a catalog of molecules and structures that scientists around the world can quickly access and use to understand the immune response to a variety of epitopes, or methodically predict responses to as-yet untested targets,” says Alessandro Sette, Ph.D., who heads the Vaccine Discovery division at LIAI and is the lead investigator on the project.

For the current study, Dr. Sette and his colleagues examined 600 different epitopes from 58 different strains of influenza A virus. One of their main goals was to determine how conserved, or similar, epitopes are between different strains of bird and human influenza viruses. Knowing this is important because the virus rapidly mutates and can swap gene segments between strains, which could increase the ability of an avian virus to be transmissible to humans.

In addition, only a handful of the epitopes are known to be associated with protective immunity. Most of the influenza virus epitopes in the database are those recognized by a type of immune cell known as a T cell; far fewer are recognized by B cells, a type of white blood cell that produces infection-fighting antibodies. Antibodies induced by seasonal and pandemic flu viruses or vaccines are a major component of immunity that protects against these viruses.

Strains of influenza virus can vary enough in their neutralizing B cell epitopes that a vaccine against one strain may not protect against another strain. But if epitopes are conserved between virus strains, the immunity a person has developed towards one strain might provide at least some protection against the other strain.

Using a software tool they developed, the LIAI team found hundreds of conserved influenza virus epitopes in the database, including those between avian H5N1 and strains of human influenza viruses. But what is less clear from the analysis is how cross-reactive an immune response would be to most of these conserved epitopes. Further analyses may assist scientists in identifying vaccine targets that might offer broader protection and in predicting how effective a new vaccine will be.

Other analyses revealed major gaps in scientists’ knowledge about influenza viruses. Of the 600 epitopes in the database, for instance, very few were from strains of H5N1 avian influenza. And even though the database contains epitopes from all the influenza virus’ proteins, the vast majority of the data relates to just two influenza proteins, the hemagglutinin (HA) and nucleoprotein (NP).

Most of the influenza virus data comes from analyses of immune responses obtained with mice; some comes from rabbits, ferrets and monkeys, and very little comes from humans or birds. In fact, only one antibody epitope came from a human. The LIAI researchers say more studies should be focused on identifying human T and B cell epitopes from human and avian strains of influenza virus--especially those associated with protective immunity.

“The bottom line is that this study shows us where we need to go,” says project director Stephen Wilson, Ph.D., chief technology officer at LIAI. “Hundreds of flu epitopes have already been published and are now in the database, but critical gaps become apparent when one looks for human antibody targets.”

Plans for the future include adding data on epitopes that are involved in autoimmune diseases and epitopes that trigger allergic and asthmatic reactions. Dr. Sette and his colleagues have also built numerous tools for analyzing and visualizing the data and for predicting immunity against different pathogens--all of which is publicly accessible on their Web site (see http://immuneepitope.org/home.do).

NIAID is a component of the National Institutes of Health. NIAID supports basic and applied research to prevent, diagnose and treat infectious diseases such as HIV/AIDS and other sexually transmitted infections, influenza, tuberculosis, malaria and illness from potential agents of bioterrorism. NIAID also supports research on basic immunology, transplantation and immune-related disorders, including autoimmune diseases, asthma and allergies.

The National Institutes of Health (NIH)—The Nation's Medical Research Agency—includes 27 Institutes and Centers and is a component of the U. S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov
 

JPD

Inactive
WHO Chief Warns Bird Flu Threat Has Not Gone Away

http://voanews.com/english/2007-01-04-voa15.cfm

By Lisa Schlein
Geneva
04 January 2007

Schlein report - Download 349k audio clip
Listen to Schlein report audio clip

The new director-general of the World Health Organization, Margaret Chan, warns the threat of an influenza pandemic has not receded. She urges countries around the world to prepare for a pandemic that has the potential to kill millions. From WHO headquarters in Geneva, Lisa Schlein reports on Dr. Chan's first news conference.

Margaret Chan, new director-general of the World Health Organization, 4 Jan 2007
Margaret Chan, 4 Jan 2007

Prior to her appointment as WHO director-general, Margaret Chan headed the organization's avian-flu pandemic program. She has been involved with efforts to combat the disease since 1997, when she headed Hong Kong's public health program.

Chan says the H5-N1 bird flu virus has caused unprecedented damage to the poultry sector since its appearance a few years ago and it has killed more than half of the people that have become infected.

She believes the available evidence indicates the world is due for another pandemic soon.

"We owe it to the community we are serving to keep our watch, to be vigilant, on the watch out for early signs of a pandemic. The risk is there," she said. "We should not let our guard down. We are very concerned of the likelihood of a pandemic and particularly its impact in weak, in countries with weak, health systems and in countries in Africa where they have many people already affected by HIV/AIDS and other diseases."

Chan says 170 countries have pandemic preparedness plans, an increase from 50 in 1997.

She says implementation of revised international health regulations in June will help countries respond more effectively to bird flu outbreaks.

Director-General Chan cites the improvement of the health of women and the people of Africa as one of her main priorities. She says the World Health Organization has numerous programs dealing with these issues and she intends to make them better.

"We have a cluster called FCH-Family and Child Health - dealing with maternal health issues, child health issues and women's issues," noted Chan. "So, if that cluster as a group performed better and got synergy from the various programs, we are making improvements in the health of women and also in the health of Africa."

If a program is not working, Chan says something new must be tried. For example, she says her predecessor, Jong-wook Lee, realized that the "Roll Back Malaria" program was not winning the battle against malaria. So he introduced a new global malaria program, which, she says, she intends to follow.

"Three-thousand children die on a daily basis because of malaria," said Chan. "This is not acceptable. So, that is why we have a program which is very aggressive and very tough."

Chan says WHO must be prepared to change course when programs are not working. Otherwise, it will not remain relevant and will be left behind.
 

JPD

Inactive
Maine

Sagadahoc prescribes door-to-door pandemic primer

http://www.timesrecord.com/website/main.nsf/news.nsf/0/AB2FE6967C560B5105257259005844A8?Opendocument

01/04/2007

BATH — If an unfamiliar person comes knocking on your door on Jan. 20 to deliver a message about the spread of a pandemic flu, don't be alarmed.

The Sagadahoc County Emergency Management Agency has coordinated an effort to go door-to-door throughout the county that day to provide residents with pocket guides about preparing for a pandemic flu that some scientists consider to be not a matter of "if," but "when."

The individual preparedness detailed in the agency's guide ranges from everyday measures such as washing hands frequently with soap and water to more long-term plans, like compiling an emergency kit with 30 days' worth of food, water, medicines and disinfectants.

n The guide also gives contact information for local, state and regional organizations trained to handle health scares.

According to Emergency Management Agency Director Misty Green, the canvass will be done in all the towns of Sagadahoc County by town officials and volunteers. It will focus on what individuals could do in a time of sweeping medical crisis. West Bath and Phippsburg, she said, are the only towns mailing the pocket guides instead of hand-delivering them.

"The key part to all of this is individual preparedness," said Green. "The towns can be ready and the county can be ready, but to stop the spread, the key is individual preparedness."

The individual preparedness detailed in the agency's guide ranges from everyday measures such as washing hands frequently with soap and water to more long-term plans, like compiling an emergency kit with 30 days' worth of food, water, medicines and disinfectants.

The guide also gives contact information for local, state and regional organizations trained to handle health scares.

The practical day-to-day tips and contact numbers might also be useful in the shadow of the standard influenza season — though not a pandemic — which was declared under way Tuesday by the Maine Center for Disease Control and Prevention.

"We have had laboratory-confirmed cases of both Influenza A and B the past few days, including one influenza-related death," announced Dr. Dora Anne Mills, director of the center. "With the reopening of schools and many returning to work this week, it is especially important that we all heed the three basic guidelines of covering coughs and sneezes; washing hands frequently; and staying home if we're ill, particularly with a fever."

Unlike the annual flu season, pandemics have occurred three times in the last century, and a Dec. 12 proclamation by the Sagadahoc County commissioners warned that "history and science suggest that the country and the world could face one or more pandemics in this century."

One particularly publicized candidate to become the next pandemic — defined as "a worldwide outbreak of a new virus for which there is little or no immunity in the human population" — is the avian influenza, or "bird flu."

The agency's guide notes that "bird flu viruses do not usually infect humans, but (the most recent) outbreak of bird flu has infected people, mainly in Southeast Asian countries."

However, the avian influenza has opened eyes regarding the possibility of a pandemic outbreak, because "scientists and health professionals are concerned about bird flu because the current virus in birds may change and develop into a virus that will spread easily from one person to another."

The commissioners thus proclaimed January to be Pandemic Influenza Awareness Month, which will be marked by several events, including the distribution of the guides.

The county's board of health will kick off Pandemic Influenza Awareness Month during its meeting at 8 a.m. Friday. On Jan. 15 and Jan. 25, individual preparedness workshops will be held at 6 p.m. at the Topsham Public Library and the Woolwich Fire Department, respectively.
 

JPD

Inactive
Vietnam warned on bird flu threat

http://news.bbc.co.uk/1/hi/world/asia-pacific/6233283.stm

Vietnam's latest outbreak of bird flu poses a huge threat to public health, the head of the World Health Organization (WHO) in the country says.

Dr Hans Troedsson said the cooler weather and forthcoming Tet festival heightened the risk of the disease spreading to the human population.

An outbreak of the lethal H5N1 strain was found on a poultry farm in December, the first in almost a year.

New WHO chief Margaret Chan has warned that bird flu remains a global threat.

Dr Chan, a bird flu expert from Hong Kong, said reports of bird flu had started to surface in recent weeks after a lull and that the danger was particularly severe in poor countries.

"We must not let our guard down. We must maintain our vigilance," she said, after becoming the first Chinese citizen to head the UN agency.

'Negative impact'

Vietnam has been widely praised by international health experts for its success in tackling the highly pathogenic avian influenza.

The country had been free of human cases of bird flu for a year - thanks to a mass culling and vaccination drive.

Dr Troedsson, the WHO's Vietnam Country Director, said last month's confirmed outbreak did not mean Vietnam's current policies had failed.

But he warned that the onset of the colder winter months - when the virus survives for longer - and February's lunar new year festivities "could have a negative impact".

"Not only the movement of people will increase but the consumption of poultry, so there will be more transport and handling and slaughtering of poultry," he told the BBC's Bill Hayton in Hanoi.

Dr Troedsson said Vietnam's government should maintain its strategy of openness, good surveillance and the vaccination of hundreds of millions of birds.

But he warned that it could take several years for the bird flu virus to be completely eradicated from the country.

Margaret Chan has pledged to take a hard line on countries that do not comply with requirements to carry out checks against bird flu or hinder global efforts to develop vaccines.

Her Chinese origin, she said, would help her in any dealing with the authorities in China, the country where the lethal H5N1 strain of bird flu first emerged.

"I think of all people I would be in a better position to work with the Chinese government," she told the BBC.
 
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