06/24-25 | Weekend BF: Common heart drugs might be bird flu weapon

PCViking

Lutefisk Survivor
Common heart drugs might be bird flu weapon
Statin drugs could turn deadly infection into a milder disease, says doctor

Updated: 4:04 p.m. ET June 21, 2006

WASHINGTON - The world’s top-selling drugs, cholesterol-lowering statins, might provide a way to treat feared bird flu, according to a doctor and retired drug company executive who is trying to get the researchers to study the possibility.

Antivirals that affect the influenza virus are in short supply, and it will be years before vaccine makers can ramp up capacity enough to immunize the world’s population against a pandemic flu.

But what if there was a cheap and widely available drug that helped treat the flu’s worst symptoms and possibly save lives?

Evidence suggests that statin drugs, designed to lower cholesterol, might help turn a potentially deadly infection into a milder disease, according to Dr. David Fedson, who thinks world health authorities ought to take a harder look at the possibility.

“Generic statins are available in virtually every country,” said Fedson, a retired U.S. physician living in France.

“You’ll be able to take five days of statins in India for less than a dollar,” Fedson, who was also director of medical affairs at Aventis Pasteur (now French drug company Sanofi Aventis, said in a telephone interview.

“We have something that conceivably could save tens of thousands of lives. This research is so important that we cannot afford not to take it.”

Fedson, an expert on vaccination, cites several recent studies that show that statins reduce inflammation. Designed to lower cholesterol, the drugs work on several biological processes and may reduce the risk of Alzheimer’s disease, some cancers, and multiple sclerosis.

In January, researchers in Canada reported that statins act against sepsis, a dangerous blood infection and a 2005 study published in the journal Respiratory Research found the death rate was 64 percent lower in pneumonia patients who had been taking statins.

Immune storm
Fedson cites yet other studies that suggest strongly that people who are infected with avian influenza have an immune system overreaction known as a cytokine storm.

Their immune system signals chemicals rush to fight off the alien virus, causing an inflammation of the lungs and other organs that may be what kills them.

“It’s an idea, just an idea and it needs to be substantiated with both cellular-based and animal-based studies,” Fedson said. “We need to do it and we need to do it fast.”

He is getting some attention.

Fedson presented his idea last week to the Congress of Infectious Diseases in Lisbon, Portugal, and is to speak to a bird flu conference next week at the Institut Pasteur in Paris. He also has a paper in next month’s issue of the journal Clinical Infectious Diseases.

Statins — which include Pfizer Inc.’s $10 billion-a-year Lipitor, Bristol-Myers Squibb Co.’s Pravachol and Merck and Co. Inc.’s Zocor — are the world’s best-selling drugs, taken by millions to reduce the risk of heart attack.

Poorly prepared
Experts say a pandemic of some sort of influenza is inevitable.

The H5N1 avian influenza sweeping countries in Asia and also affecting Europe and Africa is considered the most likely candidate. So far it has rarely infected people, but has killed 130 out of 228 infected and just a few mutations would turn it into a form that could be passed easily from one person to another.

If this happens in the next few years, the World Health Organization and other experts agree the world is very poorly prepared and that millions could die.

A WHO spokesman said the agency had no immediate comment on Fedson’s work, and spokespeople for companies that make statins said they had not looked into the possibility of testing the drugs in influenza patients.

http://www.msnbc.msn.com/id/13461236/

:vik:
 

PCViking

Lutefisk Survivor
Hong Kong; 102 cases under Surveillance

Hospital Authority's Enhanced Surveillance Programme
****************************************************

In view of a human case of avian influenza H5N1 in Shenzhen, the Hospital Authority (HA) started the three-week Enhanced Surveillance Programme from June 15, 2006.

Public hospitals should report to the authority's e-Flu system all patients fulfilling the case definition of having pneumonia (all types) of unidentified etiology and who had travelled in the seven days before the onset of symptoms, to affected areas/ countries with confirmed human cases of avian influenza infection in the past six months.

The authority today (June 23) received reports of 12 cases (seven male and five female, aged 6 months to 73 years). So far 102 cases (61 male, 41 female, aged 2 months to 89 years) have been received. These patients have visited Guangdong, Hunan, Hubei, Fujian and Zhejiang before the onset of symptoms. HA has reported the cases to the Centre for Health Protection. Public hospitals are providing rapid tests for these patients.


Ends/Friday, June 23, 2006
Issued at HKT 18:51

http://www.info.gov.hk/gia/general/200606/23/P200606230239.htm

:vik:
 

PCViking

Lutefisk Survivor
Time is GMT + 8 hours
Posted: 24 June 2006 0416 hrs

Virus that caused cluster of bird flu deaths was genetic "dead end": WHO

GENEVA - A viral strain that caused the first lab-confirmed cluster of human-to-human transmission of bird flu was a genetic "dead end" that could not have caused a pandemic, the World Health Organisation (WHO) said Friday.

Six members of the same family in Indonesia died after being in close proximity to a female relative who was infected with the H5N1 virus and who also died.

But officials for the UN's health organisation insisted Friday that the viral strain had not mutated into a form that could go beyond this group and become a potential global killer.

"The virus died out, it didn't go beyond the family. Like other cases of human-to-human transmission, this was a dead end," WHO influenza spokesman Dick Thompson said.

The cluster of seven deaths which occurred last month had raised a flurry of concern among scientists.

H5N1 circulates among wild birds and poultry, which can then hand it on to humans nearby. In its present form, it is hard to transmit from humans to humans. That so many people had been mortally infected by one patient triggered fears that the virus had now mutated into a contagious as well as lethal form.

Thompson said that the Indonesia cluster was the first case to be identified and confirmed by genetic tests as human-to-human transmission.

Previous instances, about half a dozen in all, have been determined indirectly, with epidemiologists trying to the trace the people with whom the patient has been in contact.

"We've never really had a fingerprint to confirm human-to-human transmission like we had here," Thompson said.

A "tiny" genetic change in the virus was found in samples from two of the victims, allowing scientists to identify the chain of transmission,
he added.

He also highlighted several other differences in the Indonesian case that are still under investigation.

Keiji Fukuda, coordinator of WHO's global influenza program, said in Jakarta earlier Friday that the sick woman had stayed in the same room as the other members of her family, passing on the virus through coughing. He said the virus had had a slight mutation that was insignificant.

Even so, scientists are curious about two key differences in the Indonesian human cluster, Thompson said.

One is its relatively large size compared with other instances found in Asia, where the virus spread directly from the initial victim to just a handful of other people.

The other is the discovery through laboratory tests that the father was not infected directly by his sister, the initial victim, but one step further along the chain through a son who had caught the virus.


"This is something we've never seen before either," Thompson said.

However all the victims were in close contact with each other and there was no sign after weeks of monitoring that more than 50 of the father's other contacts had bird flu, he added.

Nearly 130 people have died of bird flu around the world since late 2003,the vast majority of them in Asia. Vietnam accounts for 42 and Indonesia for 39.

In Paris, influenza expert Jean-Thierry Aubin of France's Pasteur Institute, said "this big cluster has been analysed top to bottom, and no sample has offered any evidence which would indicate that the virus has adapted to a human host. All its genes are purely those of avian flu."

Aubin said the cluster had occurred because the family members had been in very close contact. Such rare events could not be ruled out "in any biological event, because human-to-human transmission is not something that is yes or no," he said.

http://www.channelnewsasia.com/stories/afp_asiapacific/view/215394/1/.html

:vik:
 

PCViking

Lutefisk Survivor
Indonesia

Residents refuse bird flu testing

JAKARTA: Health Minister Siti Fadillah Supari is gravely concerned about some North Sumatra villagers' refusal to have their blood tested for the avian flu virus after a bird flu outbreak killed seven people in the Tanah Karo regency.

"Maybe, the residents there have yet to receive proper information about bird flu," she said before attending a Cabinet meeting.

Tanah Karo residents are also refusing to let officials check their chickens for the flu, insisting there is no incidence of the disease in their area.

The government plans to cull all chickens in a one-kilometer radius in all areas testing positive for the virus.
-- JP

http://www.thejakartapost.com/detailnational.asp?fileid=20060623.H04&irec=7

:vik:
 

JPD

Inactive
S227N Change in H5N1 Receptor Binding Domains in Turkey

http://www.recombinomics.com/News/06230603/H5N1_S227N_Turkey_Cases.html

Recombinomics Commentary
June 23, 2006

Recently the sequences of all 8 gene segments of four human isolates from Turkey were released by WHO Influenza Centre National Institute for Medical Research, National Institute for Medical Research, The Ridgeway Mill Hill, London. Two of the isolates, A/Turkey/12/2006(H5N1) and A/Turkey/15/2006(H5N1) were from the index case and his sister, respectively. It seems likely that the other two isolates, A/Turkey/651242/06(H5N1) and A/Turkey/65596/06(H5N1), were from the other two fatalities, a third sibling and a cousin, respectively.

Media reports had indicated that the H5N1 from the index case had a change in the receptor binding domain of the HA gene. This change, S227N, had been shown to increase the affinity for alpha 2.6 receptors, which are found in the upper respiratory tract of humans. The acquisition was predicted to take place in the Middle East via recombination with H9N2, which was another bird flu virus that was endemic to the region. However, the WHO had issued an update on mutations indicating that the S227N was transient because the H5N1 from sister of the index case did not have this change, suggesting that the change arose in the index case via random mutation.

Analysis of the newly released sequences indicated that one of the later isolates, Turkey/65596, which probably came from the cousin, also had S227N. This polymorphism is rare in H5N1. It was first seen in isolates from family members from Hong Kong who had been infected in Fujian Province in 2003. These isolates, A/Hong Kong/212/2003(H5N1) and A/Hong Kong/213/2003(H5N1) were from a father and son and both had S227N. There were also reports of S227N in a Vietnam isolate in 2005.

However, there were no reports of S227N in Qinghai isolates, so the likelihood that S227N would arise independently in the two Turkish cases via random mutation is remote. Moreover, the failure to find S227N in the other two isolates may be related to isolation procedures. In Hong Kong, both isolation procedures used mammalian MDCK dog kidney cells. Isolation in chicken eggs may select against S227N. Moreover, the timing or location of the tissue or fluid used to isolate the H5N1 may dictate the level of S227N, which would be less likely to grow in lung. Lung was the source of the positive PCR data on the fatal cases.

The finding of S227N in a second isolate suggests the acquisition was via recombination, and the change may have been more stable that initially thought. The cluster in Turkey was the largest reported and it involved several related families. There were also outbreaks nearby in Iraq and Azerbaijan. The HA of the Turkey isolates is closely related to HA from bird, cat, and human isolates from Iraq. The nearby Azerbaijan outbreak was also large and extended. Thus, S227N may have contributed to the size of these clusters.

The release of the four sequences add important information on the receptor binding domain change, S227N. The WHO is monitoring adjacent positions, 226 and 228 for additional receptor binding changes. Acquisition of human polymorphism at these positions may greatly increase the affinity of H5N1 for upper respiratory receptors in humans, leading to more efficient transmission, which is the missing condition required for a catastrophic pandemic.
 

JPD

Inactive
Mystery Deepens on Possible Avian Flu Case in China in 2003

http://www.nytimes.com/2006/06/24/world/asia/24china.html?_r=1&oref=slogin

By DONALD G. McNEIL Jr.
Published: June 24, 2006

Did China have a death from avian flu two years before it admitted having any human cases?

The mystery deepened yesterday, and the possibility was raised that someone had tried to block publication of that event from a prestigious American medical journal.

The New England Journal of Medicine reversed an announcement it had made two days before, saying the eight Chinese authors of a letter describing a man's death in 2003 from avian flu had insisted that they really did want it printed.

The timing of the death is important because scientists believe that the A(H5N1) avian flu virus had percolated in China's chickens for many years, but it was not until last November that the government admitted to having a human case; it has officially reported 19 cases and 12 deaths. In 2003, China covered up dozens of SARS deaths for months after the epidemic began there.

The journal had gone to press on Wednesday when the editors received several e-mail messages asking that the letter describing the 2003 death not be printed. One appeared to come from the e-mail address of the letter's chief author, Dr. Wu-Chun Cao, of the State Key Laboratory of Pathogens and Biosecurity.

Yesterday, the journal's editors said that they had reached Dr. Cao, and that he had denied sending that e-mail message. At their request, they said, he faxed a signed statement saying he stood by what he and his co-authors had written. However, Sandra Jacobs, a journal spokeswoman, said it had no earlier examples of his signature for comparison.

The editor who spoke to Dr. Cao, she said, did not want to disclose whether he knew why or how an e-mail message had been forged. Dr. Cao did not respond to e-mail messages from The New York Times.

The letter said that doctors initially thought the 24-year-old man had SARS, but tests on his lung tissue proved negative. It did not say when the flu tests were done, and it did not note the discrepancy between the date of his death and China's tally.

It did detail the genetics of the virus found, saying different portions resembled A(H5N1) viruses found in 2004 in three regions of China and one region in Japan, and concluding that the virus that killed him was a mixed virus, and different from others found in humans. This could complicate efforts to make a vaccine, it noted. The World Health Organization's China office has asked the government to explain the discrepancy.

Liu Pengyu, a consul in the press office of the Chinese Consulate in New York, said yesterday that he knew nothing about the study, but did not believe his government would try to cover up an earlier death from avian flu. Pointing out that it had been widely criticized for concealing its SARS epidemic, he said: "Our prime minister takes a very serious stance on these issues. We don't think there is anything to hide."
 

JPD

Inactive
EXCLUSIVE: BIRD FLU?

EXCLUSIVE Fear as lab workers are isolated after being gashed by needles infected with deadly H5N1 bug

http://www.mirror.co.uk/news/tm_obj...headline=exclusive--bird-flu---name_page.html

24 June 2006

By Robert Stansfield

TWO women technicians have been quarantined and vaccinated for suspected bird flu.

One is still confined to her house - and yesterday enraged officials by briefly leaving the property and putting the public at risk.

The other is back at work but is still being regularly tested for the deadly H5N1 strain of the flu virus.

Both work in the avian biology section of the Veterinary Laboratories Agency, which analyses samples from diseased creatures. They became suspects within eight days of each other. A source said: "No one can believe that this has happened twice in just over a week.

"There've been accidents in the past, but never in this lab."

Yesterday an expert warned that even with no outward sign of the disease, the lab workers could still be lifelong carriers.

The women, aged 25 and 50, are feared to have caught H5N1 after slashing their hands with infected blood stained needles.

The 25-year-old pierced herself on Wednesday while injecting chick embryos with H5N1 during tests.

She must spend 10 days in isolation at her home in Addlestone, Surrey, while blood and saliva are analysed.

She has to take her own DNA swabs to prevent cross-contamination.

The samples are collected from her doorstep by couriers. Nurses keep in regular phone contact. Yesterday, the technician breached Department for the Environment, Food and Rural Affairs rules by leaving her house.

Our source said: "Bosses will be furious she's put people at risk. She'll be kept in isolation for 10 days. If she doesn't fall ill, she'll be allowed back."

The woman was confined as her colleague was allowed back to work after piercing her protective gloves while dissecting an infected duck 11 days ago.

An exclusion zone was placed around the woman's home in the grounds of the VLA compound in Weybridge, Surrey, while tests were carried out. The worker has shown no signs of the virus. But she will continue to be monitored as H5N1 can lie dormant in the body for months.

Our insider said: "She came back when scientists were sure she couldn't spread any infection. They're testing her regularly to check her condition doesn't change."

The technician only recently transferred to the avian biology section to help deal with the rising backlog of tests.

Bird flu expert Clifford Warwick said yesterday the virus could flare up months after infection. He said: "H5N1 can go undetected in the body for years.

"Stress such as surgery could lower a person's immune system and allow the dormant virus to take hold. The disease would then be strong enough to get into red blood cells and could be passed through the air, in the breath or sneezes."

Defra said the technicians were given Tamiflu vaccine immediately after their accidents, though it is not a certain cure for the virus.

A spokesman said: "Both were sent home as a precaution. Neither has shown any ill effects. Both incidents are very low risk."

THE Health Protection Agency yesterday played down fears of a bird flu pandemic after it was confirmed H5N1 may have mutated to kill eight members of the same family in Indonesia.

Scientists said the virus died with the last victim and the threat was no greater than before.

b.stansfield@mirror.co.uk
 

PCViking

Lutefisk Survivor
Siberia

Russia Reports H5N1 Bird Flu Strain In Siberian Tuva

MOSCOW (Dow Jones)--The Siberian office of the Russian emergencies ministry announced Friday that an outbreak of the H5N1 strain of bird flu had been registered in the constituent Tuva Republic.

The statement said 169 dead wild birds had been collected from the Ubsu-Nur Lake in the Ovyursky district of the Tuva Republic, and the presence of H5N1 in their blood samples had been confirmed by the Kemerovo veterinary laboratory.

Although the emergencies ministry said no more dead birds had been found by Thursday, it warned that further outbreaks are likely towards the end of July among young wild birds as their immunity to the disease is weak.

(END) Dow Jones Newswires

June 23, 2006 05:23 ET (09:23 GMT)

http://framehosting.dowjonesnews.com/sample/samplestory.asp?StoryID=2006062309230011&Take=1

:vik:
 

PCViking

Lutefisk Survivor
The Tamiflu 'mafia'

June 24, 2006

Afghanistan came first. Then Iraq. The next battleground will not be Iran, but Cornwall's pastoral idyll where present and constant danger lurks amidst thyme and rosemary.

No revolutionary cell was ever as lethal as the West Cornwall Small Shepherds Club; no samizdat more subversive than its newsletter. Its tentacles spread across the globe, recalling in the tranquillity of the Cornish village of Gwithiam, the bird flu that ravaged an obscure pocket of Maharashtra. Fearing that the disease might spread to humans, the Indian government reportedly bought up all the Tamiflu tablets it could lay hands on. The original being so expensive, it also sought licensed manufacture in India.

Sheila Sexton of Tregarne, stalwart of the West Cornwall Small Shepherds Club, and Tess Nash who edits its monthly newsletter, knew then they would have to fight to save Animal Farm going the way of Iraq. It was in the rambling farmhouse of Charles and Joyce Sanderson's Reskajeage Farm, cunningly designed to withstand siege and fox the invader with its unsuspected corridors, tucked away rooms and innocent clusters of medieval outhouses that I chanced upon the clarion call against Bush's neo-conservatives.

Until then I had missed the telltale resistance preparations. Screeching seagulls drown the manufacture of a new generation of weapons of mass destruction -- murderous spades and pitchforks and man-traps like Elizabethan stocks cunningly disguised as instruments for treating sheep with rotten feet. Rabbits dart out of hawthorn hedges to lay red herrings across the trail. Silent as the foreign hand, lamas scan the horizon for the enemy. Miniature ouessant are ready to savage them on arrival.

Sexton's message, published as a question-and-answer article in the newsletter's June edition and punctuated with the editor's pungent comments, deserves reproduction in full. So here goes, with apologies to Nash.

"Bird Flu"
"Do you know that 'bird flu' was discovered in Vietnam nine years ago?

Do you know that barely 100 people have died in the whole world in all that time?

Do you know that it was the Americans who alerted us to the efficacy of the human antiviral drug, TAMIFLU, as a preventative?

Do you know that TAMIFLU barely alleviates some symptoms of the common flu?

Do you know that its efficacy against the common flu is questioned by a great part of the scientific community?

Do you know that to date, Avian Flu affects birds only?

Do you know that against a SUPPOSED mutant virus such as H5N1, TAMIFLU barely alleviates the illness?"

The coup de grace follows.

"Do you know who markets TAMIFLU?

Answer: Roche Laboratories.

Do you know who bought the patent for TAMIFLU from Roche Laboratories in 1996?

Answer: Gilead Sciences Inc

Do you know who was the then president of Gilead Sciences Inc and remains a major shareholder?

Answer: Donald Rumsfeld, the present Secretary of Defence of the USA.

Do you know that the base of TAMIFLU is crushed aniseed?

Do you know who controls 90 per cent of the world's production of this tree?

Answer: Roche Laboratories.


Do you know that sales of TAMIFLU were over $254 million in 2004 and more than $1,000 million in 2005?

Do you know how many more millions Roche can earn in the coming months, if the business of fear continues?"

Nash intervenes, "Neither do we, but it's an awful lot!"

The article continues:

"So the summary of the story is as follows:

Bush's friends decide that the medicine TAMIFLU is the solution for a pandemic that has not yet occurred, and that has caused only a hundred deaths worldwide in nine years.

This medicine doesn't so much cure the common flu, let alone anything as reportedly virulent and lethal to humans as the H5N1 virus.

In normal conditions, the H5N1 virus does not affect humans."

Another Nash intervention, "And as yet, is showing no signs of mutating to infect human to human, either".

Sexton continues:

"Rumsfeld sells the patent for TAMIFLU to Roche for which they pay him a fortune.

Roche acquires 90 per cent of the global production of crushed aniseed, the base for the antivirus.

The governments of the entire world threaten a pandemic, and then buy industrial quantities of the product from Roche.

So we, the taxpayers, end up paying huge sums for an ineffective medicine, while Rumsfeld, Cheney and Bush do 'The Business'."

Nash has the last word. "Shades of Mafia, perhaps?"


No, that's not Calcutta's Coffee House speaking. It's the whisper that can be heard among Stone Age barrows in Cornwall's placid fields and the ruins of Victorian tin mines where Bush's mission to bring freedom and democracy to the world faces severe resistance. Small shepherds are obviously in cahoots with Al Qaeda, the Taliban and even Saddam Hussein since they object to his neocon cronies making money.

Sound the trumpets. Muster the next coalition of the willing. It matters not whether Nash or Sexton is Osama bin Laden in drag. Cornwall must be liberated. America will not be savaged by sheep or shepherds.

http://ia.rediff.com/money/2006/jun/24guest1.htm

:vik:
 
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<B><font size=+1 color=red><center>Human-to-Human Infection by Bird Flu Virus Is Confirmed</font>

June 24, 2006
By ELISABETH ROSENTHAL
Boston.com
<A href="http://www.boston.com/yourlife/health/other/articles/2006/06/24/human_to_human_infection_by_bird_flu_virus_is_confirmed/">LINK</a></center>
Sign up for: Globe Headlines e-mail | Breaking News Alerts ROME, June 23 — An Indonesian who died after catching the A(H5N1) bird flu virus from his 10-year-old son represents the first confirmed case of human-to-human transmission of the disease, a World Health Organization investigation of an unusual family cluster has concluded, the agency said Friday.</b>

The W.H.O. investigators also discovered that the virus had mutated slightly when the son had the disease, although not in any way that would allow the virus to pass more readily among people.

"Yes, it is slightly altered, but in a way that viruses commonly mutate," said Dick Thompson, a spokesman for the agency in Geneva. "But that didn't make it more transmissible or cause more severe disease."

The greater importance of the slightly modified virus is that it allowed researchers from the W.H.O. and the Centers for Disease Control and Prevention in the United States to document that the virus almost certainly was passed from person to person.

In previous cases where human-to-human transmission was suspected, researchers could not test samples from the patients, or the virus in the patients was the same as that in poultry in the area.

The genetics work vindicates some Internet flu watchers who had disputed statements by a W.H.O. official and the Indonesian Health Ministry soon after the cluster was reported, saying it was possible the whole family had been infected by a barbecued pig, poultry or chicken manure.

The independent flu watchers, relying on local Indonesian news media, had argued that the pattern of dates on which different family members fell ill suggested that the virus had jumped from human to human to human.

Scientists have long said the A(H5N1) virus, which has killed or led to the culling of hundreds of millions of birds worldwide, does not spread easily to humans or among them. But they have worried that it might mutate to acquire that ability, setting off a devastating pandemic.

More than 200 people have contracted bird flu worldwide, almost all of them after very close contact with infected birds.

International health officials have been in Indonesia for much of the past month, investigating a family outbreak that affected seven relatives in Kubu Sembilang, a remote village in the mountainous Karo district of Sumatra. Six of the seven died, and one is still hospitalized.

Although Indonesia has been struggling all year to control bird flu outbreaks among poultry, the family on Sumatra had no known direct contact with sick birds, although the first to die was a woman who sold vegetables in a market that also sold birds.

But scientists have long suspected that A(H5N1), though an avian virus, could also spread between people in rare cases, if there was prolonged close contact.

The family members in the cluster had a banquet in late April when the vegetable merchant was already ill and coughing heavily. Some spent the night in the same room with her, and some nursed sick relatives.

The first five family members to fall ill had identical strains of A(H5N1), one found in animals in Indonesia. But that virus had mutated slightly in the sixth victim, a child, and he apparently passed the mutated virus to his father, who cared for him in a hospital without proper protection, said Dr. Tim Uyeki, an American epidemiologist on the W.H.O. team.

Still, Mr. Thompson said there was no evidence that the mutated virus was better adapted to human infection. To the contrary, the agency has been following 54 relatives and neighbors for a month and none have caught it.

"So we know it is not more easily transmitted," he said.
 
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<B><center>June 24. 2006 6:59AM

<font size=+1 color=brown>Bird flu mutation found
Experts don't see an increase in risk of pandemic.</font>

NATION/WORLD
MARGIE MASON
Associated Press Writer
<A href="http://www.southbendtribune.com/apps/pbcs.dll/article?AID=/20060624/News03/606240375/-1/NEWS03/CAT=News03">LINK</a></center>
JAKARTA, Indonesia -- The World Health Organization has detailed the first evidence that a person likely caught the bird flu virus from a human, then passed a slightly mutated version to another person. But experts said Friday the genetic change does not increase the threat of a pandemic.</b>

The investigation said the mutation of the H5N1 strain of the virus occurred in a 10-year-old Indonesian boy who was part of the largest cluster ever reported. The index case is believed to have been infected by poultry. She then likely passed it to the boy and five other blood relatives. The boy is then thought to have infected his father, whose samples showed the same mutation, according to the report obtained by The Associated Press.

Only one infected family member survived.


"It stopped. It was dead end at that point," said Tim Uyeki, an epidemiologist from the U.S. Centers for Disease Control and Prevention.

Uyeki, who was part of the investigating team, stressed that viruses are always slightly changing, and there was no reason for this mutation to raise alarm because the virus has not developed the ability to spread easily among people.

U.N. bird flu chief David Nabarro said the findings nevertheless emphasized the importance of continuous monitoring of the H5N1 virus in both humans and poultry.

"We were fortunate in that the change that took place did not result in sustained human-to-human transmission," he said by telephone Friday. "This is a vivid reminder of the need to keep a very close watch on what the virus is doing."

Experts fear the H5N1 virus could eventually mutate into a highly contagious form that spreads easily among people, potentially sparking a global pandemic. The current virus remains hard for people to catch, and most human cases have been traced to contact with sick birds.

The WHO report was distributed during a three-day meeting in Jakarta attended by some of the world's top bird flu experts. Indonesian officials called the closed-door session to ask for help in coping with the virus, which has infected more people in Indonesia this year than anywhere else -- killing an average of one person every 2 1/2 days last month.
 
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<B><center>Sat, Jun. 24, 2006
<font size=+1 color=green>It's time to prepare your bird-flu plan</font>

Jerry Osteryoung
Small Business
<A href="http://www.bradenton.com/mld/bradenton/business/14890781.htm">LINK</a></center>
As business owners and managers, our responsibilities include preparing for the uncertain future. While no one knows for sure the extent of the threat posed by a pandemic bird flu, we still need to confront the potential risk.</b>

During the 20th Century there were three major pandemics. The first was the Spanish flu of 1918-1919 during which, according to the Centers for Disease Control and Prevention, 500,000 people died in the United States. Then, in 1957-58 the Asian flu caused the deaths of 70,000 people throughout the nation. Finally, the 1968-1969 Hong Kong flu resulted in 34,000 American deaths. Bottom line is that these pandemic flu outbreaks are fairly common and very costly.

The CDC estimates that a medium-level pandemic could easily cause at least 89,000 deaths, over 700,000 hospitalizations and somewhere between 20 to 40 million outpatient visits. About 25 percent of the population could be affected.

According to the World Health Organization, there have been 191 diagnoses of bird flu resulting in 108 deaths since 2003. As of now the virus is not easily spread from human to human but that could change.

Obviously, you should have a plan in place before a pandemic reaches your community. Clearly, you do not want to scare people but on the other hand you need to make adequate preparation and have all staff involved in this planning process.

The plan should measure the impact the flu will have on your business in every area of operations. What will happen if you cannot get your supply of raw materials? What will happen if 50 percent of your labor force is ill for a month? How will you adjust to reduced cash-flow in these scenarios?

Think through the options for maintaining clear lines of communication very carefully. Who will be in charge of this and who will be the back-up? How will you maintain contact with your staff, customers and vendors to let them know how you are faring?

Try running an exercise to test how well your planning can be implemented and where it needs improvement. A practice run is invaluable for revealing any flaws in your preparations.

Think about any adjustments to your sick-leave policy if this flu hits. What will you do if an employee has to go home and care for a sick spouse or family member?

The government has a great web site at jostery@comcast.netwww.pandemicflu.gov provides information that will help you plan for this potential crisis.

One additional thing I would strongly recommend is to encourage your staff to get their flu shots. According to the CDC, a flu shot won't inoculate you against a pandemic flu virus but it will help keep you healthy, thereby minimizing your chance of getting sick.

Planning for a potential pandemic, like any other catastrophe, is just good business. Now go out and make sure you have a great plan.

Jerry Osteryoung is an FSU finance professor and executive director of the Jim Moran Institute for Global Entrepreneurship at Florida State University's College of Business. He writes a weekly column dispensing small business advice and has authored eight books, including "So You Need to Write a Business Plan!" He can be reached by email at jostery@comcast.net or by phone at (850) 644-3372.
 
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<B><font size=+1 color=blue><center>Six Respirator Manufacturers Warn President Bush Of Imminent Shortage Of Masks Necessary For Avian Flu Pandemic Response</font>

Main Category: Bird Flu / Avian Flu News
Article Date: 24 Jun 2006 - 0:00am (PDT)
Public HealthMedical Devices
<A href="http://www.medicalnewstoday.com/medicalnews.php?newsid=45879">LINK</a></center>
The leaders of six respirator manufacturers representing approximately half the respirator production capacity of the United States urged President Bush in a letter delivered today to the White House to back federal legislation ensuring the supply and availability of disposable respirator masks (N-95 respirators) for healthcare workers and other first responders. The letter from the industry echoes a letter sent to the Administration in May by a bipartisan group of 86 Members of Congress calling for the National Strategy for Pandemic Flu Influenza to stockpile N-95 respirator masks instead of surgical masks. </b>

"Unfettered liability costs will dramatically affect our nation's ability to respond to an avian flu pandemic," wrote the respirator company executives. "Costs of defending litigation, aside from settlements or verdicts, amount to hundreds of millions of dollars. In fact, currently, 90 to 94 percent of profits are being consumed to maintain litigation efforts.

"Disposable respirators are inexpensive, so there is no practical way to add unfair liability costs to the price of our products," the letter continues. "Thus, we are compelled to withhold further investment in production capacity, exit the marketplace or manufacture abroad for foreign buyers where no litigation crisis exists. This is not in the public interest. Respirator manufacturers are not, and have never been, part of the problem underlying end-user illnesses, but we can be part of the solution to minimize the spread of avian flu in the U.S. if a pandemic occurs."

The National Institute for Occupational Safety and Health (NIOSH) tightly regulates the respirator industry by setting strict design standards, conducting tests to ensure they are met, and approving each and every respirator model as well as the warning labels that accompany the product. However, relying on asbestos-style litigation tactics, trial lawyers have deluged the industry with lawsuits claiming defective design or failure to warn users -- despite the fact that manufacturers cannot affect how or when the respirators are used.

"Without legislation, the ability for American manufacturers to address emergency preparedness or have surge production capacity is and will be severely constrained," wrote the company heads. "Already, one major manufacturer has announced that it will no longer produce N-95 respirators for the industrial market. Another is seriously considering withdrawing from the market, and it has become difficult to convince shareholders to invest in new capacity in the United States."

France has begun stockpiling 685 million N-95 respirator masks just for first responders, while the U.S. Government to date has had one request for proposals for 50 million masks. The recent experience with SARS showed that countries will embargo exports of respirator masks in the case of a global pandemic and the US will need its domestic sources for these masks.

The Coalition urged President Bush to support bi-partisan legislation introduced by Senators John Cornyn (R-TX) and Ben Nelson (D-NE) in the Senate (S. 1406) and Representatives Bud Shuster (R-PA) and Tim Holden (D-PA) in the House (H.R. 2357) that would preempt lawsuits claiming defective design or insufficient warning if a respirator is NIOSH-approved.

The six manufacturers who sent the letter include members of the Coalition for Breathing Safety: Aearo, Bacou-Dalloz, Inovel, Moldex, MSA and North Safety. The Coalition for Breathing Safety was formed in 2004 to ensure that millions of emergency responders, workers and citizens across the globe continue to have access to respiratory safety products. For additional information, please visit http://www.breathingsafety.org

Coalition for Breathing Safety
http://www.breathingsafety.org
 
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<B><center>06/24/2006 12:00:00 AM PDT

<font size=+1 color=purple>Officials fear state unprepared for bird flu virus
Widespread infection would strain health care</font>

BY TROY ANDERSON, Staff Writer
<A href="http://www.dailynews.com/news/ci_3974373">LINK</a></center>
As health officials announced Friday the first evidence of Avian influenza spreading from person to person, Southland experts said they are growing increasingly alarmed that cities and hospitals are drastically unprepared for a possible pandemic.

Hospital officials, in particular, are concerned that federal preparation is not adequate as birds carrying the virus come closer to the United States, said James Lott, executive vice president of the Hospital Association of Southern California.</b>

"We have an opportunity here in California to have hundreds of thousands of people infected by the bird flu when it does arrive and insufficient funding and planning has been done to prepare California to deal with this level of a catastrophe," Lott said.

"The fact the governor is stepping up to the plate with a proposal to add $400 million to the budget to prepare California is testament to the fact that the federal government's response has been inadequate."

Gov. Arnold Schwarzenegger unveiled the plan Friday, proposing the extra funds to help the state's health system prepare for disasters by purchasing mobile field hospitals, antiviral drugs, ventilators, protective equipment and other supplies.

Lott said the funds will help, but the federal government needs to provide far more.

In January, U.S. Health and Human Services Secretary Mike Leavitt came to Los Angeles and said the federal government would provide $100 million for pandemic flu preparations, including $6.7 million for California and an additional $2.9 million for the county.

But Lott said Friday, "We've seen very little of that funding. We've seen very little come to the front lines."

Carol Meyer, director of the county's Emergency Medical Services Agency, said none of that money is going to private hospitals, which make up the vast majority of area facilities.

Adm. John Agwunobi, assistant secretary of health for HHS, said an additional $250 million will be provided to the states in the next few months.

Earlier this week, Leavitt announced that Congress had approved the president's 2006-07 emergency funding request of $2.3 billion to prepare for a pandemic. An undetermined amount of those funds will go to states and counties.

Agwunobi said that's on top of more than $6 billion in bioterrorism funds the federal government

has provided to states and counties since 2001 to increase hospital surge capacity and enhance public health.

"The funding is ongoing for health infrastructure and hospital surge capacity," Agwunobi said. "I want to stress, however, that pandemic influenza preparedness is not only the responsibility of the federal government."

Currently, Lott said, hospitals in the state have 35,000 ventilators but estimate they would need 350,000 to effectively deal with a pandemic.

"We could have more people hospitalized than we've ever had before," Lott said. "Each of the mobile hospitals have 400 beds apiece, so we'll have surge capacity.

"But we've got hundreds of thousands of people in nursing homes who are going to be highly at risk, children and other people with compromised immune systems."

County Public Health Officer Dr. Jonathan E. Fielding said that, in the event of a pandemic, staffing would be the biggest challenge.

"We already have a nursing shortage," Fielding said. "So if a substantial portion of the work force was ill or had to take care of loved ones who were ill, I think we're going to have significant stress in terms of being able to staff the existing hospitals, let alone surge capacity."

So far the virus has killed tens of thousands of birds and 130 people in Asia, Eastern Europe and Africa. But experts are concerned that it could mutate into a form easily transmissible among people.

On Friday, World Health Organization officials said they had the first evidence that the bird flu virus had mutated and spread from person to person within a family in Indonesia.

Health experts said the spread was limited to the family and that the genetic change does not increase the threat of a worldwide pandemic.
 
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<B><center>06/24/2006 12:00:00 AM PDT

<font size=+1 color=red>Hospitals may not be ready for bird flu
Federal funding must be upped, officials say</font>

By Troy Anderson Staff Writer
<A href="http://www.pasadenastarnews.com/news/ci_3974385">LINK</a></center>
As health officials announced Friday the first evidence of Avian influenza spreading person to person, Southland experts said they are growing increasingly alarmed that cities and hospitals are drastically unprepared for a possible pandemic.

Hospital officials, in particular, are concerned that federal preparation is not adequate as birds carrying the virus come closer to the United States, said James Lott, executive vice-president of the Hospital Association of Southern California.</b>

"We have an opportunity here in California to have hundreds of thousands of people infected by the bird flu when it does arrive and insufficient funding and planning has been done to prepare California to deal with this level of a catastrophe," Lott said.

"The fact the governor is stepping up to the plate with a proposal to add $400 million to the budget to prepare California is testament to the fact that the federal government's response has been inadequate."

Gov. Arnold Schwarzenegger unveiled the plan Friday, proposing the extra funds to help the state's health system prepare for disasters by purchasing mobile field hospitals, antiviral drugs, ventilators, protective equipment and other supplies.

Lott said the funds will help, but the federal government needs to provide far more.

In January, U.S. Health and Human Services Secretary Mike Leavitt came to Los Angeles and said the federal government would provide $100 million for pandemic flu preparations, including $6.7 million for California and an additional $2.9 million for the county.

But Lott said Friday, "We've seen very little of that funding. We've seen very little come to the front lines."

Carol Meyer, director of the county's Emergency Medical Services Agency, said none of that money is going to private hospitals.

"Where do think the patients are going to go?" Meyer asked. "There was also nothing for emergency medical services. Who do think is going to be responding?

"We think there needs to be some emphasis on hospitals because they are going to be overwhelmed."

Adm. John Agwunobi, assistant secretary of health for HHS, said another $250 million will be provided to the states in the next few months.

Earlier this week, Leavitt announced Congress had approved the president's 2006-07 emergency funding request of $2.3 billion to prepare for a pandemic. An undetermined amount of those funds will go to states and counties.

Agwunobi said that's on top of more than $6 billion in bioterrorism funds the federal government has provided to states and counties since 2001 to increase hospital surge capacity and enhance public health.

"The funding is ongoing for health infrastructure and hospital surge capacity," Agwunobi said. "I want to stress, however, that pandemic influenza preparedness is not only the responsibility of the federal government.

"As we travel the nation, we're urging local and state governments and the federal government to come together in partnership in investing,

planning and preparing for a pandemic."

Currently, Lott said hospitals in the state have 35,000 ventilators, but estimate they would need 350,000 to effectively deal with a pandemic.

"We could have more people hospitalized than we've ever had before," Lott said. "Each of the mobile hospitals have 400 beds apiece. So we'll have surge capacity.

"But we've got hundreds of thousands of people in nursing homes who are going to be highly at risk, children and other people with compromised immune systems. So we're looking at huge numbers of patients we'll have to have ventilators for."

County Public Health Officer Dr. Jonathan E. Fielding said that in the event of a pandemic, staffing would be the biggest challenge.

"We already have a nursing shortage," Fielding said. "So if a substantial portion of the workforce was ill or had to take care of loved ones who were ill, I think we're going to have significant stress in terms of being able to staff the existing hospitals, let along surge capacity. It's not like we'll be able to draw substantial numbers of people from outside the area.

So far the virus has killed tens of thousands of birds and 130 people in Asia, Eastern Europe and Africa. But experts are concerned that it could mutate into a form easily transmissible among people.

On Friday, World Health Organization officials said they had the first evidence that the bird flu virus had mutated and spread from person to person within a family in Indonesia.

Health experts said the spread was limited to the family and the genetic change does not increase the threat of a worldwide pandemic.

"There has been no evidence of significant person to person spread, but the more this spreads around the world it makes us incredibly concerned about the possibility of a mutation," Fielding said.

Meanwhile, although Canadian officials reported last week that a goshing had tested positive for the H5N1 virus, officials said Tuesday the bird did not die of the highly pathogenic strain of bird flu found throughout Asia, Europe and Africa.

In Alaska, U.S. Fish and Wildlife spokesman Bruce Woods said officials are continuing to test birds for the virus coming over the Asian-Australian flyway.

"I think that probably the closest it is now is in Russia, Vietnam or Cambodia," Woods said.
 
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<B><center>June 22, 2006 01:13 pm

<font size=+0 color=brown>Flu pandemic stats hint at stark reality</font>

<font size=+1 color=purple>Local health expert says pandemic is near</font>

BRIAN L. HUCHEL
<A href="http://www.commercial-news.com/local/local_story_173131309.html">LINK</a></center>
DANVILLE — No influenza pandemic exists. But the potential for as many as 29,000 cases and 600 deaths in Vermilion County makes current preparation necessary for future survival.

“We’re damned if we do and damned if we don’t,” local health department community relations coordinator Linda Bolton told about 30 people Wednesday. “So we darn well better start planning.”
</b>
County health officials gathered local representatives from a variety of areas to look for ideas and to discuss a preliminary draft of a pandemic flu plan for Vermilion County.

Representatives from CRIS Senior Services, Provena United Samaritans Medical Center and the Department of Veterans Affairs Illiana Health Care System joined the afternoon meeting.

County officials, including Sheriff Pat Hartshorn and Emergency Management Director Bob Huff, also attended.

Health Department Administrator Steve Laker said the draft is just the first phase of the process and preparations are “behind the curve.”

“This is going to have to be an organic process, a dynamic process that will last for some time,” he said.

Meeting attendees took away preliminary drafts of the pandemic plan with the request that they return comments and opinions to the health department by June 30. Another meeting will take place in mid- or late July to go over a revised version of the plan.

The county health department must send its plan to the state by Aug. 1.

According to the plan’s current draft, Vermilion County could see 12,600 to 29,400 cases of influenza during a pandemic. Hospitalizations could reach 2,500, and people who die as a result of the pandemic could range between 200 and 600.

Danville Mayor Scott Eisenhauer, who attended the meeting, questioned the planning, noting the state and cities like Danville have spent time preparing for other problems, such as the West Nile virus.

“And none of that has really come to a conclusion,” he said. “So, I’m concerned we’re going to start working on a pandemic before it’s decided there’s no money and there’s not time because we’ve got something new.”

Laker said this situation isn’t going away.

“I’m not trying to make this doom and gloom, people,” he said. “I’m trying to make this as real as possible.

“This is impending.”

Laker said the country has been at what is considered the third phase of a pandemic for two years. A pandemic is split into six phases, the final being sustained transmission among the general public.
 

PCViking

Lutefisk Survivor
UK Lab technicians infected with H5N1

Saturday, June 24, 2006

2 spiked by bird flu bug

By EMMA MORTON

TWO workers at Britain’s bird flu testing centre needed emergency treatment after being jabbed accidentally by needles infected with the deadly virus.

The women worked in labs at the Veterinary Laboratories Agency in Weybridge, Surrey, analysing birds contaminated by the H5N1 virus.


The first technician was working with dead duck samples on June 14 when a needle pierced her protective clothing.

She was placed in quarantine after being given a dose of the anti-viral drug Tamiflu.

In the second blunder on June 20, a worker was handling samples of the virus and accidentally jabbed herself. She was rushed into an isolation unit and given emergency drugs.

Meanwhile, the virus spread between seven members of a family in Sumatra, Indonesia, after appearing to MUTATE, experts revealed yesterday.

The World Health Organisation think one family member caught it and passed it on in what was probably the first time the virus passed along a chain.

http://www.thesun.co.uk/article/0,,2-2006290206,00.html

:vik:
 

PCViking

Lutefisk Survivor
24 June 2006
EXCLUSIVE: BIRD FLU?
EXCLUSIVE Fear as lab workers are isolated after being gashed by needles infected with deadly H5N1 bug
By Robert Stansfield

TWO women technicians have been quarantined and vaccinated for suspected bird flu.

One is still confined to her house - and yesterday enraged officials by briefly leaving the property and putting the public at risk.

The other is back at work but is still being regularly tested for the deadly H5N1 strain of the flu virus.


Both work in the avian biology section of the Veterinary Laboratories Agency, which analyses samples from diseased creatures. They became suspects within eight days of each other. A source said: "No one can believe that this has happened twice in just over a week.

"There've been accidents in the past, but never in this lab."

Yesterday an expert warned that even with no outward sign of the disease, the lab workers could still be lifelong carriers.

The women, aged 25 and 50, are feared to have caught H5N1 after slashing their hands with infected blood stained needles.

The 25-year-old pierced herself on Wednesday while injecting chick embryos with H5N1 during tests.

She must spend 10 days in isolation at her home in Addlestone, Surrey, while blood and saliva are analysed.

She has to take her own DNA swabs to prevent cross-contamination.

The samples are collected from her doorstep by couriers. Nurses keep in regular phone contact. Yesterday, the technician breached Department for the Environment, Food and Rural Affairs rules by leaving her house.

Our source said: "Bosses will be furious she's put people at risk. She'll be kept in isolation for 10 days. If she doesn't fall ill, she'll be allowed back."

The woman was confined as her colleague was allowed back to work after piercing her protective gloves while dissecting an infected duck 11 days ago.

An exclusion zone was placed around the woman's home in the grounds of the VLA compound in Weybridge, Surrey, while tests were carried out. The worker has shown no signs of the virus. But she will continue to be monitored as H5N1 can lie dormant in the body for months.

Our insider said: "She came back when scientists were sure she couldn't spread any infection. They're testing her regularly to check her condition doesn't change."

The technician only recently transferred to the avian biology section to help deal with the rising backlog of tests.

Bird flu expert Clifford Warwick said yesterday the virus could flare up months after infection. He said: "H5N1 can go undetected in the body for years.

"Stress such as surgery could lower a person's immune system and allow the dormant virus to take hold. The disease would then be strong enough to get into red blood cells and could be passed through the air, in the breath or sneezes."

Defra said the technicians were given Tamiflu vaccine immediately after their accidents, though it is not a certain cure for the virus.

A spokesman said: "Both were sent home as a precaution. Neither has shown any ill effects. Both incidents are very low risk."

THE Health Protection Agency yesterday played down fears of a bird flu pandemic after it was confirmed H5N1 may have mutated to kill eight members of the same family in Indonesia.

Scientists said the virus died with the last victim and the threat was no greater than before.

http://www.mirror.co.uk/news/tm_obj...teid=94762&headline=bird-flu---name_page.html

:vik:
 

PCViking

Lutefisk Survivor
Mystery thickens around report of early Chinese bird flu case
16:14:27 EDT Jun 23, 2006
HELEN BRANSWELL

(CP) - The mystery surrounding a report by Chinese researchers that contradicts Beijing's official line on how long China has been having human cases of H5N1 avian flu took a twist Friday that suggests someone may have tried to block the report's publication in a prestigious medical journal.

Hours before the official release of this week's issue of New England Journal of Medicine, editors at the journal received a series of e-mails from someone purporting to be Dr. Wu-Chun Cao, one of the authors of the report which had been submitted by eight Chinese scientists.

But on Friday, editors at the journal spoke by phone with someone they believe to be Cao. He categorically denied having sent the e-mails and told the journal he and his co-authors stand behind their report.


Cao, of the State Key Laboratory of Pathogens and Biosecurity, later faxed the journal a letter reaffirming those claims.

"He has not requested withdrawal of the report, and so it stands as published in the issue of June 22," Dr. Jeffrey Drazen, editor-in-chief, said in a statement.

"We are continuing to investigate."

The eight researchers reported on the molecular characteristics of an H5N1 virus isolated from a Chinese man who died in November 2003.

The report has stirred up intense interest in the scientific world because that was two full years before Beijing first reported a human H5N1 case to the World Health Organization, in November 2005.

The authors made no reference to the discrepancy between their report and China's official H5N1 timeline. Nor did they indicate whether the testing that discovered H5N1 virus in the dead man's lung was actually done around the time of death or more recently.

When the report was published the WHO's China office formally requested that the Chinese Ministry of Health explain the discrepancy and provide information about the case.

On Friday, a WHO spokesperson in Geneva declined to comment on the latest development.

Influenza experts outside China have long believed the country has hidden or missed human cases of H5N1, but they hadn't anticipated seeing proof in the pages of one of the world's most prestigious medical journals. China has officially reported 19 cases and 12 deaths.

A spokesperson for the New England Journal of Medicine said the journal had received "multiple" e-mails asking to withdraw the report. From the e-mail addresses, some seemed to be from Cao; others claimed to be from all eight authors.

"It seemed very clear that they were coming from Dr. Cao and/or that institution," Karen Pedersen said from Boston. Copies of the e-mails were also faxed to the journal.

But editors could not immediately reach Cao to explore why he wanted the report pulled and to explain it was too late - the journal had been printed and mailed to subscribers days earlier.

On Friday someone identifying himself as Cao called the journal and said he hadn't made the request and didn't want to withdraw the report. Pedersen said the journal editors believe that call was legitimate.

The editors asked Cao to submit a letter reaffirming that the report should stand, and they received that letter. Pedersen said the journal was in the process Friday of getting the remaining seven researchers to sign similar letters.

http://www.cbc.ca/cp/health/060623/x062320.html

:vik:
 

PCViking

Lutefisk Survivor
Iowa

Counties reviewing quarantine rules in case of avian flu outbreak

Sunday, June 25, 2006 6:12 AM CDT

By TOM BARTON
Courier Staff Writer
INDEPENDENCE --- Public health officials will likely take a harder stance than your mother.

No chicken soup or spoonful of medicine. Instead, try a written quarantine or isolation order and the threat of simple misdemeanor charges.


As the recent mumps epidemic is contained, state and county officials are focusing more attention on another potential problem, an outbreak of avian influenza. And in an effort to assesses state preparedness, the Iowa Department of Public Health's Center for Disease Operation and Response is working with county and local governments to develop and review emergency response plans.

Part of the process is encouraging many entities to update quarantine and isolation ordinances.

Buchanan County supervisors are scheduled to vote on a third and final reading of a new ordinance Monday. The policy would give the board authority to segregate individuals with communicable diseases, such as avian flu, measles or smallpox.

Amy Marlow, community care manager at the Buchanan County Health Center, said generally most people cooperate voluntarily.

" ... But sometimes individuals do not comply, and in that situation, the county and local law enforcement need to be able to have the authority to step in and intervene," Marlow said.

If approved, county officials could file simple misdemeanor charges against those who refuse to play nice.

Marlow said as it stands, supervisors and the Buchanan County Board of Health would have to wait for an order from the Iowa Department of Public Health before isolating or quarantining residents. That, she said, presents problems in the county's ability to stop the spread of disease.

"The bottom line is to stop the spread of disease. This gives the county the authority to act immediately in its best interest to stop a pandemic from escalating," Marlow said.

She cautioned the ordinance is not meant to be confrontational.

"It's not to be a threatening situation, but a cooperative situation."

The county supervisors, along with the board of health, hospitals and law enforcement, would still coordinate efforts with the state and would follow similar procedures used by the Iowa Department of Public Health.

"Under Iowa law there's dual jurisdiction. Either the state or the local government can issue a quarantine. County governments have the authority to quarantine a person, but we need to make sure those ordinances are established and have enforcement provisions," said Heather Adams of the Iowa Attorney General's Office.

She represents the Iowa Department of Public Health.

"It's putting meat on the bones," Adams said.

Fayette and Black Hawk counties, along with 39 others, also are in the process of adopting similar ordinances. Forty-eight counties in Iowa have policies in place, including Butler, Bremer, Grundy and Benton.

The most recent example of using such an ordinance was in 2004. Johnson County quarantined eight individuals who contracted measles.

After Sept. 11, 2001, the Iowa Department of Public Health ordered a comprehensive review of its disaster preparedness, including quarantine policies, which Marlow maintains is a good idea.

"We feel we could handle what comes our way, should something happen, but the key is to have ongoing planning -- that these rules, ordinances and guidelines don't sit on the shelf and become outdated," she said.

The Buchanan County Health Department is revising its existing emergency response plan to include pandemic flu. Officials declined to release the plan's provisions, citing sensitive information they said is protected from disclosure under Iowa law.

In general terms, Marlow said the department is looking at policies and procedures for shutting down operations in the county in the event of a problem.

"That trucker bringing in supplies who isn't affected but maybe coming into an area that is affected -- do we let him in? How do we control movement in and out of the county?" she said.

Buchanan County received $8,000 from the Iowa Department of Public Health to develop an emergency response plan. Black Hawk County received $25,000 in federal funds to plan for pandemic flu and is in the initial stages of assembling its plan. Next year, Iowa will receive $1.2 million in federal funding for pandemic planning and operations, according to the governor's office.

Last Monday, two dozen scientists from around the world gathered in Ames to learn how to diagnose avian flu and control its spread. Ames is home to the National Veterinary Services Lab, which will determine whether H5N1, a highly pathogenic bird flu virus, has arrived in the United States.

The virus spread from Asia, where officials slaughtered 200 million birds, and moved on to Africa and Europe. The virus has killed at least 124 people. Scientists are concerned H5N1 could mutate into a form that can travel from human to human.

http://www.wcfcourier.com/articles/2006/06/25/news/regional/021e4bea54740fc886257197007f5f91.txt

:vik:
 
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<B><font size=+1 color=red><center>Bird flu pandemic could result in one thousand 9/11s - doctor</font>

14:12pm 25th June 2006
<A href="http://www.dailymail.co.uk/pages/live/articles/news/news.html?in_article_id=392396&in_page_id=1770">LINK</a></center>
A flu pandemic across the UK could result in "1,000 September 11ths" and preparations are "woefully inadequate", a doctor warned today.

Dr Steve Hajioff will tell doctors at the British Medical Association's annual conference on Tuesday that a flu pandemic would have "enormous" implications. He believes stockpiling anti-virals is less important than getting transport, fuel and water companies to make adequate plans. </b>

He said: "We are expecting a real flu pandemic of the kind we have not seen for years and this is one of the biggest catastrophes. What's more, it's a totally predictable one but if we act now we can mitigate its effects."

Dr Hajioff, a GP from central London, said the 1918 pandemic saw 40% of the population taken ill and 2.5% of the population die.

"In the present day, you are talking about five million people across Europe and hundreds of thousands in the UK," he said. "It's like 1,000 September the 11ths all at once. That's if it's as bad as 1918, but we hope and pray that it won't be.

"Still, there's enormous potential for damage and we need to prepare now."

Dr Hajioff said the Government had taken action but stocking anti-viral drugs was the "icing not the cake".

He added: "It's not anti-virals that are important, it's how we keep going, keep functioning as a country and keep the flu from spreading. I'm a GP and I can prepare my surgery, but if the electricity company that supplies my power has not prepared, then I am not going to be able to treat patients.

"If the telephone company has not done its work then my patients cannot phone in. Things like this are even more important in a hospital setting. If the emergency fuel for the generators doesn't arrive or people can't get to work, the implications are enormous.

"It's the power, the transport, the water companies who need to prepare, but there needs to be contingency plans in every organisation."

On Friday, the World Health Organisation released a report confirming evidence of human-to-human H5N1 bird flu virus transmission in Indonesia. There are fears that H5N1 will spark a worldwide flu pandemic if it mutates to a level where it passes easily between humans.

Dr Hajioff said current predictions for the UK were that 25% of the population would be affected by a flu pandemic and be off work. But, he added, carers would stay at home, people with colds would stay off and then there were many more who might "take sickies".

"This means that 40% could be away from work at any one time," he said.

Dr Hajioff will debate the issue in a motion at the BMA conference saying preparations are "woefully inadequate".
 
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<B><font size=+1 color=brown><center>UK 'Not Ready' For Flu</font>

Updated: 07:27, Sunday June 25, 2006
<A href="http://www.sky.com/skynews/article/0,,30100-13529749,00.html">LINK</a></center>
Preparations for a flu pandemic across the UK are "woefully inadequate", a doctor is warning.

British Medical Association's annual conference is to be told that a flu pandemic would have enormous implications in Britain.

Dr Steve Hajioff, a GP from central London, claims the number of deaths could be equivalent to "1,000 September 11ths". </b>

He believes stockpiling anti-virals is less important than getting transport, fuel and water companies to make adequate plans.

"We are expecting a real flu pandemic of the kind we have not seen for years and this is one of the biggest catastrophes," he said.

"What's more, it's a totally predictable one but if we act now we can mitigate its effects."

Dr Hajioff said 40% of the population was taken ill 2.5% died in the 1918 pandemic.

"In the present day, you are talking about five million people across Europe and hundreds of thousands in the UK," he said.

Dr Hajioff said the Government had taken action but stocking anti-viral drugs was the "icing not the cake".

He added: "It's not anti-virals that are important, it's how we keep going, keep functioning as a country and keep the flu from spreading."
 
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<B><center>HLT-UK-BIRD FLU
<font size=+1 color=green>Bird flu pandemic "potentially disastrous'</font>

<A href="http://www.kuna.net.kw/Home/Story.aspx?Language=en&DSNO=880169">LINK</a></center>
LONDON, June 25 (KUNA) -- A bird flu pandemic across the UK could result in "1,000 September 11s" and preparations are "woefully inadequate,", a leading British doctor warned Sunday.

Dr. Steve Hajioff was telling doctors at the British Medical Association's annual conference this Tuesday that a flu pandemic would have "enormous" implications, the British media reported.</b>

He believes stockpiling anti-virals is less important than getting transport, fuel, and water companies to make adequate plans. He said "We are expecting a real flu pandemic of the kind we have not seen for years and this is one of the biggest catastrophes.

"What's more, it's a totally predictable one but if we act now we can mitigate its effects." Dr. Hajioff, a GP from central London, said the 1918 pandemic saw 40 percent of the population taken ill and 2.5 percent of the population die.

"In the present day, you are talking about five million people across Europe and hundreds of thousands in the UK ... It's like 1,000 September the 11ths all at once ... That's if it's as bad as 1918, but we hope and pray that it won't be. Still, there's enormous potential for damage and we need to prepare now." Dr. Hajioff said the Government had taken action but stocking anti-viral drugs was the "icing, not the cake." He added "It's not anti-virals that are important, it's how we keep going, keep functioning as a country and keep the flu from spreading.

"I'm a GP and I can prepare my surgery, but if the electricity company that supplies my power has not prepared, then I am not going to be able to treat patients. If the telephone company has not done its work then my patients cannot phone in.

"Things like this are even more important in a hospital setting. If the emergency fuel for the generators doesn't arrive or people can't get to work, the implications are enormous.

"It's the power, the transport, the water companies who need to prepare, but there needs to be contingency plans in every organisation." Last Friday, the World Health Organisation released a report confirming evidence of human-to-human H5N1 bird flu virus transmission in Indonesia.

There are fears that H5N1 will spark a worldwide flu pandemic if it mutates to a level where it passes easily between humans.

Dr. Hajioff said current predictions for the UK were that 25 percent of the population would be affected by a flu pandemic and be off work.(end) he.

wsa
 
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<B><font size=+1 color=blue><center>Scientists Aim To Thwart Use Of Flu As Bioweapon</font>

Main Category: Bio-terrorism / Terrorism News
Article Date: 25 Jun 2006 - 2:00am (PDT)
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Flu is already a big killer, responsible for more than 35,000 deaths in the United States alone each year. And wild birds infected with the deadly H5N1 strain of bird flu are gradually broadening the scope of that disease. Last week in Rochester, scientists were discussing ways to better understand the flu and also how to prevent the possibility that terrorists could somehow modify flu as a bioweapon to make it even more lethal than it is already. </b>

Among the highlights of last week's two-day symposium, hosted by the University of Rochester Center for Biodefense Immune Modeling, was a lecture by Nobel Prize winner Peter Doherty, Ph.D., an expert on how flu spurs the immune system to defend itself against the infection. Doherty's technical talk on the roles of specific types of T-cells in influenza were on June 23, at the Rochester Marriott Airport Hotel on West Ridge Road.

During the symposium Thursday and Friday, University of Rochester experts in mathematics, statistics, immunology, and infectious diseases joined with colleagues from around the nation to discuss exactly how flu invades the body, how the body responds, and how mathematicians, statisticians, and computer scientists are working to help understand the pathogenesis of flu infection. The group talked about the potential of flu to be intentionally modified for use as a lethal weapon more deadly than bird flu, and ways to prevent that from happening.

"Flu viruses are deadly - witness the 1918 Spanish flu which killed millions of people - and with modification, they can be made even more deadly," said Hulin Wu, Ph.D., professor in the Department of Biostatistics and Computational Biology and director of the modeling center. Wu's colleague, Martin Zand, M.D., Ph.D., co-director of the center, added that "We don't know whether flu will be weaponized; it's crucial to ask the question and to be prepared."

The focus of Wu's center, funded by the National Institutes of Health, is the mathematical modeling of infectious diseases. When the flu virus infects the body, for instance, a cascade of complex events occur to fight the virus as it commandeers cells and begins churning out viral particles that attack the body. The immune system falls back on an array of cells, especially antibody-producing B-cells and flu-killing T cells, to fight back. Understanding just how that occurs, and simulating that with computers, is the goal of the center.

Wu points to the improved treatment of HIV as an area where such an approach has already yielded enormous benefit to patients. Once considered a death sentence, HIV infection is now more commonly viewed as a chronic infection thanks largely to improved treatment. Much of the improvement is due to early mathematical models that helped scientists and physicians understand and target the disease more effectively.

"How flu infects the body and how the body responds to a flu infection is not understood completely," said Wu. "Mathematical models will help guide flu experts to ask the right questions, so that we understand it more thoroughly than we do today. Understanding exactly what is happening should help scientists evaluate how the virus will respond to drugs designed to treat an infection."

Since flu is already a killer, the discussions will have an immediate application among scientists looking for ways to stop or better treat "natural" flu. The work also helps scientists like John Treanor, M.D., and David Topham, Ph.D., who are designing and testing new vaccines designed to prevent all types of flu, including bird flu. The University is recognized internationally as a leader in the testing of bird-flu vaccines.

"For many years people did not recognize the importance of flu research," said Topham, associate professor of Microbiology and Immunology and a scientist in the David H. Smith Center for Vaccine Biology and Immunology. "Flu research was seen as humdrum and routine, and there was no driving force to do that research. It just sort of blended into the background. People assumed that since there is a vaccine, it wasn't a disease of interest any more.

"But with bird flu on the horizon and the vaccine shortages that have occurred in recent years, it's become a hotbed of research interest. Besides, flu is responsible for 35,000 deaths and 200,000 hospitalizations in the United States alone. It's a serious health problem," Topham added.
 

JPD

Inactive
Amantadine Resistance in Karo Cluster in Sumatra Indonesia

http://www.recombinomics.com/News/06250601/H5N1_Karo_Amantadine.html

Recombinomics Commentary
June 25, 2006

The recent meeting on human H5N1 in Indonesia revealed additional detail on the sequences from the Karo cluster and presented several phylogenetic trees representing various genes of the humans isolates.

The H5N1 isolates from the Karo cluster had been described in a prior WHO update. The update had some information on the bird flu sequences of the H5N1 genes from the family members. In the WHO update, the Tamiflu sensitivity of the isolates was noted.

Full genetic sequencing of two viruses isolated from cases in this cluster has been completed by WHO H5 reference laboratories in Hong Kong and the USA. Sequencing of all eight gene segments found no evidence of genetic reassortment with human or pig influenza viruses and no evidence of significant mutations. The viruses showed no mutations associated with resistance to the neuraminidase inhibitors, including oseltamivir (Tamiflu).

The human viruses from this cluster are genetically similar to viruses isolated from poultry in North Sumatra during a previous outbreak.


However, the report failed to mention that all isolates were amantadine resistant. Data at the conference indicated that most of the human isolates in Indonesia were resistant. Prior media reports had indicated that human isolates were sensitive.

In addition, information was presented on the father of the 10 year old nephew of the index case. Media reports had indicated a minor mutation had linked the isolates from the father and son. However, in addition to the minor mutation shared by father and son, the father had 8 additional changes in HA, 3 in NA and 2 in M. These changes suggest that the father had been infected with another flu virus, leading to acquisition of a number of polymorphisms by recombination.

The rapid accumulation of polymorphisms, coupled with amantadine resistance, is cause for concern.

Amantadine resistant isolates:

S31N

A/Indonesia/160H/2005 16F East Jakarta
A/Indonesia/534H/06 18M Karo-North Sumatra
A/Indonesia/535H/06 1.5F Karo-North Sumatra
A/Indonesia/536H/06 29M Karo-North Sumatra
A/Indonesia/538H/06 19M Karo-North Sumatra
A/Indonesia/546H/06 10M Karo-North Sumatra
A/Indonesia/560H/06 35M Karo-North Sumatra

V27A

A/Indonesia/245H/2005 7M East Jakarta
A/Indonesia/286H/2006 4M Indramayu
A/Indonesia/283H/2006 13F Indramayu
A/Indonesia/304H/2006 15M Indramayu
A/Indonesia/292H/06 9F Indramayu
A/Indonesia/239H/2005 39M South Jakarta
A/Indonesia/6H/2005 37F West Jakarta

Amantadine sensitive

A/Indonesia/542H/2005 12M Bekasi-West Java
A/Indonesia/7H/2005 23M Bogor-West Java
A/Indonesia/341H/06 27F Cibinong_West Java
A/Indonesia/321H/06 23M East Jakarta
A/Indonesia/554H/06 18M Kediri-East Jakarta
A/Indonesia/175H/2005 20F North Jakarta
A/Indonesia/298H/2006 22M South Jakarta
A/Indonesia/5/2005 38M Tangerang-Bantan
A/Indonesia/195H/2005 20F Tangerang-Bantan
A/Indonesia/557H/06 39M West Jakarta
 

JPD

Inactive
H5N1 Genetic Instability in Karo Cluster in Sumatra Indonesia

http://www.recombinomics.com/News/06250602/H5N1_Instability_Karo.html

Recombinomics Commentary
June 25, 2006

The recent workshop in Jakarta on human H5N1 in Indonesia provide additional detail on genetic changes associated with the Karo cluster. The cluster involved 8 members of the same family, the index case, her two sons, here three siblings, and two children of the siblings. Seven of the eight family members died, including the index case. A seven relatives of the index cases were H5N1 positive and the workshop presented sequence information on the six family members who died.

Five of the six developed symptoms are the time of death of the index case. The H5N1 from these five family members were remarkable similar. The H5N1 from the two son, IDN/534H/06 and IDN538H06 had one difference from the consensus sequence for all eight gene segments, NP G555A. the H5N1 from the daughter of the sister of the index case, IDN/535H/06 had one other change, M G953A. All other positions were identical in all five family members. A later isolate from the 10 year old nephew of the index case, IDN/546bH/06 had one additional change HA C29T. The father of the nephew, developed symptoms when his son died.

Analysis of the H5N1 from the nephew's father, IDB/560H/06 had the same change in HA, C29T. This sharing of the HA polymorphism suggested that the nephew infected his father, which was not unexpected because of the disease onset date for the father, as well as the close contact between father and son before the son died.

However, the H5N1 from the father had eight additional polymorphism in HA (C105A, T120C, C396A, G512A, A579G, G729A, C819A, C1276T). In addition, there were three polymorphisms in NA (T608C, T651C, T657T) as well as two polymorphisms in M (A651G and A918G). Thus, the other family member had zero or one difference with consensus H5N1 sequence of the cluster, while the H5N1 from the nephew's father had 14. The high number of changes suggest the involvement of a second virus resulting in a recombinant with the 14 differences.

This explosion in genetic changes over a short time period is cause for concern. The sharing of HA T29C between father and son suggests the isolate from the father was a recombinant, rather than an independent isolate. However, both alternatives require a second infection in a family member within a couple of weeks of the infection of the other family members, who were almost certainly infected by the index case.

The concentration of fatal H5N1 in this family is cause for concern. It was the largest and most deadly cluster in Indonesia to date and involved two distinct H5N1 sequences. Symptoms in the infected father were noted by a reporter, raising additional concern over the effectiveness of contact tracing.

Although there spread of these two viruses appears to be contained, the increased efficiency of H5N1 infections in Indonesia raises more red flags. The HA of human H5N1 isolates in Indonesia are represented in a phylogenetic tree. The Karo cluster (shadowed in pink) is distinct with the larger cluster of human cases, primarily in western Java (green isolates on bottom branch of the tree). The vast majority of these isolates have a novel cleavage site, RESRRRKKR, which is not present in the bird isolates from Indonesia. Moreover, the human and cat isolates are readily distinguished from the avian isolates raising serious question about the origin of the human bird flu infection.

Immunological cross-reactivity between the isolates in western Java and Sumatra are limited, suggesting two vaccines just for the human isolates from Indonesia may be required.

H5N1 in humans in Indonesia is clearly not under control. The sequences from the human isolates remain sequestered, and the number of animal isolates remains low. Moreover the bird isolates have not matched the human isolates in western Java.

An increased effort and additional transparency in Indonesia is long overdue.
 

Y2kO

Inactive
Statin drugs are not heart drugs. And there is no established relationship between cholesterol and heart attacks. However, there is a strong established relationship between statin drugs and the break-down of muscle tissue, which then overloads the liver (blood filtration) with muscle tissue. A significant percentage of the population are harmed by statin drugs.
 

PCViking

Lutefisk Survivor
Y2kO said:
Statin drugs are not heart drugs. And there is no established relationship between cholesterol and heart attacks. However, there is a strong established relationship between statin drugs and the break-down of muscle tissue, which then overloads the liver (blood filtration) with muscle tissue. A significant percentage of the population are harmed by statin drugs.

:sht: Personally pharmaceuticals scare the crap out of me... they're un-natural and mess with your body chemistry... too often one requires another, and before you know it there is a smorgasbord of pills for what originally was one.
_________________

Y2K0, I'm interested in learning more about this Statin Drug - Muscle Tissue Breakdown... Could you post or PM me some links so I can get smarter on it?

-thanx -pcv
 
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