03/31 | Daily Bird Flu Thread: Here's the number to report questionable dead birds

PCViking

Lutefisk Survivor
Link to yesterday's thread: http://www.timebomb2000.com/vb/showthread.php?t=191627

Since January, 2004 WHO has reported human cases of avian influenza A (H5N1) in the following countries:

* East Asia and the Pacific:
o Cambodia
o China
o Indonesia
o Thailand
o Vietnam

* Europe & Eurasia:
o Azerbaijan
(see update)
o Turkey

* Near East:
o Iraq

For additional information about these reports, visit the
World Health Organization Web Site.

Updated March 21, 2006

Since December 2003, avian influenza A (H5N1) infections in poultry or wild birds have been reported in the following countries:

* Africa:
o Cameroon
o Niger
o Nigeria

* East Asia & the Pacific:
o Cambodia
o China
o Hong Kong (SARPRC)
o Indonesia
o Japan
o Laos
o Malaysia
o Mongolia
o Myanmar (Burma)
o Thailand
o Vietnam

* South Asia:
o Afghanistan
o India
o Kazakhstan
o Pakistan (H5)

* Near East:
o Egypt
o Iraq (H5)
o Iran
o Israel
o Jordan

* Europe & Eurasia:
o Albania
o Austria
o Azerbaijan
o Bosnia & Herzegovina
o Bulgaria
o Croatia
o Denmark
o France
o Georgia
o Germany
o Greece
o Hungary
o Italy
o Poland
o Romania
o Russia
o Serbia & Montenegro
o Slovak Republic
o Slovenia
o Sweden
o Switzerland
o Turkey
o Ukraine


For additional information about these reports, visit the
World Organization for Animal Health Web Site.

Updated March 29, 2006

http://www.cdc.gov/flu/avian/outbreaks/current.htm

WHO, Avian Flu Timeline in .pdf: http://www.who.int/csr/disease/avian_influenza/timeline.pdf

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PCViking

Lutefisk Survivor
U.S. Fish and Wildlife Service hotline at 1-866-5-BRDFLU (1-866-527-3358)

State agencies detail state preparations regarding avian flu

March 29, 2006
Wednesday

The Directors of Alaska Wildlife Conservation and Alaska Public Health and the State Veterinarian today provided detailed briefings to legislators regarding the State's cooperative and coordinated efforts regarding Asian H5N1 avian influenza, and introduced the state's new interagency website that provides Alaskans with a single source for all state information related to avian and pandemic flu.

"To date, H5N1 has never been found in Alaska or anywhere in North America, and there is no evidence that anyone, anywhere has caught it from a wild bird," said Matt Robus, Fish & Game's Director of the Division of Wildlife Conservation. "At this point, there is no need to stop hunting and eating wild birds in Alaska. We are working closely with federal, state, and local officials to ensure that if the Asian H5N1 flu virus makes its way to Alaska, that it is detected early."

Robus, Department of Environmental Conservation's State Veterinarian Bob Gerlach, and Department of Health and Social Services' Public Health Director Dr. Mandsager each spoke regarding steps their departments are taking to detect and respond to any appearance of Asian H5N1 avian flu in Alaska.

With the first migratory birds expected to arrive in the state within the next two weeks, Fish & Game and federal wildlife agencies are continuing to monitor migrating birds for the virus. Fish & Game, in conjunction with its federal partners, has published informational materials and provided information on the State interagency website regarding the Asian H5N1 avian flu, how to report sick or dead birds, and steps that hunters and subsistence food gatherers can take to protect themselves while in the field or while handling wild birds and game.

Both Environmental Conservation and Fish & Game officials gave warnings regarding boiling water, or properly washing berries, bird eggs or other vegetation for human consumption that may have been contaminated by bird droppings. They also stressed the need to cook meat all the way through to 165 degrees F (or until the juices run clear) to protect against all bacteria and viruses.

Environmental Conservation is educating the public on how individuals can protect domestic birds - from backyard poultry flocks to parrots. Dr.Gerlach described symptoms to look for and what to do if Alaskans suspect they have a sick bird. "Bird owners are the first line of defense to protect their birds from avian influenza," Gerlach said. Dr. Gerlach recommends that any sick birds be isolated immediately and access to the related flock be restricted. "If you find a sick or dead bird, and no obvious cause is apparent, do not touch it." Dr. Gerlach stated. Instead, call 1-866-5brdflu (1-866-527-3358).

"The DEC Environmental Health laboratory is obtaining approval from USDA to test bird samples for Avian Influenza so that we can test samples as soon as April," said Kristin Ryan, Director of the Division of Environmental Health. "It is essential that a facility in Alaska has the capacity to test bird sample results so we can quickly identify threats and protect public health."

Departments of Fish and Game and Environmental Conservation are working with the Division of Public Health to prepare to respond to possible detection of Asian H5N1 avian flu in Alaska. Public Health has established a resource and referral phone line to have a single point of contact to respond to public health questions and concerns regarding human health concerns or planning for pandemic flu.

The Division of Public Health is planning for a potential flu pandemic if Asian H5N1 avian flu becomes transmittable between humans. "No one knows for sure when the next pandemic may strike or whether or not it will be related to the current Asian H5N1 avian flu virus," Dr. Mandsager said. "Now is the right time to plan for the complex issues and serious impacts that a new influenza pandemic could cause in Alaska. The more Alaskans who understand the issues and participate in the planning Ñü whether it is at the personal, community or state level Ñü the better off we all will be should a pandemic or another disaster strike."

More information regarding the avian flu and pandemic flu is available at a single location, provided by all three departments to ensure consistent information is available to Alaskans: www.pandemicflu.alaska.gov or www.avianflu.alaska.gov.

To report dead or sick birds, where no obvious cause is apparent, call the U.S. Fish and Wildlife Service hotline at 1-866-5-BRDFLU (1-866-527-3358). The Public Health pandemic flu phone line will be operational Thursday, March 30, and will be 1-888-9Panflu (1-888-972-6358). Anchorage residents can call the local line: (907) 334-2292.

http://www.sitnews.us/0306news/032906/032906_avian_flu.html

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PCViking

Lutefisk Survivor
1918 Spanish Flu spread directly from birds to humans

Clues from 1918 pandemic could help stop bird flu

David Batty
Wednesday March 29, 2006

The bodies of victims of the 1918 global flu pandemic should be exhumed to help prevent the spread of bird flu in humans, a virologist said today.

Tests on complete bodies of victims of the 1918 pandemic - which spread directly from birds to humans and killed up to 50 million people - would allow scientists to discover which organs the virus affected, John Oxford, the professor of virology at Queen Mary's medical school in London, said.

Prof Oxford said tests would make it possible to determine whether the flu had caused conditions such as inflammation of the brain.

He added that doctors in the UK and USA only have five tissue samples from victims of the 1918 pandemic, even though it killed more people than the first world war.

The virologist will tell a Royal Society of Medicine conference in Sheffield today that the aim should be to collect at least 100 tissues samples from across the world.

"A full body would be difficult to obtain, but it would allow us to find out why people died, for example by discovering whether the virus affected the brain and caused encephalitis," he said.

"We should get samples from 1916 and 1917 to investigate the onset of the outbreak and 1919 to investigate why it died out."

The professor said exhumations had already been carried out in the Artic and from lead-encased victims in London, while lung samples had been obtained from hospital pathology stores and museums.

This had given scientists the complete genetic sequence of the 1918 virus and shown that it spread directly from birds to humans, he added.

Prof Oxford said preparations to tackle a human outbreak of bird flu were now well advanced and there was a possibility that, for the first time in history, a global pandemic could be prevented.

"The preparations are huge now compared to a year ago," he said. "For the first time in history, we have a range of antiviral drugs and vaccines to counteract the expected first and second waves of infection. Scientists are now thinking we could stop an outbreak right at the start."

Bird flu has spread from poultry, infecting humans in seven countries. The World Health Organisation recognises 91 deaths from the 169 cases recorded globally so far.

http://www.guardian.co.uk/birdflu/story/0,,1742282,00.html?gusrc=ticker-103704

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PCViking

Lutefisk Survivor
Bird-Flu Pandemic Would Likely Start in California
And it would sweep across the U.S. in less than a month, study predicts

March 30, 2006

By Ed Edelson
HealthDay Reporter

THURSDAY, March 30 (HealthDay News) -- If a bird-flu pandemic does hit the United States, it may well start in California and spread across the country in just two to four weeks.

And the best way to slow its spread would be to have workers stay at home.

That's the scenario drawn from results of a computer model created by researchers at the U.S. National Institutes of Health's Fogarty International Center. And while the results of that computer model should be interpreted with caution, it is based on data from ordinary flu epidemics for the last three decades, said study author Dr. Mark A. Miller, associate director for research at the center.

"The unique feature of this model is that it challenges conventional wisdom, which says that flu is spread by children bringing it back to the household," Miller said. "That may be true at the household level, but regionally it is spread by adults."

That's why measures to keep people at home could slow the spread of infection, Miller said. Another finding in the study is that states with large populations, such as California, are more likely to reach epidemic levels of the flu at the same time than less-populous states, where transmission tends to be more erratic, he said.

So California, the most populous state, would be the most logical place for a pandemic to start, Miller said. Another factor pointing toward California is that bird -- also called avian -- flu is expected to arrive from Asia, he said.

As for the speed of spread, the estimate is based on ordinary epidemics. "What we see is that epidemics with more pathogenic viruses spread more quickly, two to four weeks versus five to seven weeks for less pathogenic viruses nationwide," Miller said.

The findings appear in the March 31 issue of the journal Science.

The Fogarty researchers used epidemiological data on seasonal flu epidemics that have occurred yearly in the United States since 1972. They connected that information with data from the Census Bureau and the federal Department of Transportation, looking at variations in yearly epidemics from state to state and links with local flows of people to workplaces.

Bird flu is pathogenic, but it does not yet spread easily from person to person; close exposure to an infected bird is needed to cause a human infection. The danger will come when, and if, a mutation makes human-to-human transmission easy.

Since 2003, the H5N1 bird flu virus has been detected in 45 countries in Africa, Asia, and Europe. More than 100 people have died after coming into contact with infected poultry.

The model developed by the Fogarty researchers can go just so far in predicting what might happen if such a mutation occurs, Miller said. This model notably doesn't include previous pandemics, just ordinary epidemics, and a pandemic might have different characteristics, he said.

Still, the model can help plan for ordinary, predictable epidemics by showing how they start and spread, Miller said. It's also not the first of its kind, he said: "We did a similar model to explain the spread of measles."

More information

For more on bird flu, visit the U.S. Centers for Disease Control and Prevention.

http://www.healthday.com/view.cfm?id=531827

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New Freedom

Veteran Member
http://www.wxyz.com/wxyz/health/article/0,2132,WXYZ_15919_4583244,00.html

Bird Flu Stockpile

By Carolyn Clifford
Web produced by Sarah Morgan
March 30, 2006

Bird flu isn’t expected to hit Michigan any time soon, but when— or if—it does, you’ll want to be prepared.

Some experts say if there is a pandemic we may need to stay in our homes for anywhere from a couple of weeks to three months. That means you may want to begin stockpiling food now.

Dietian Gail Posner came up with a list of items we should have in our homes.

Powdered Milk
Dried Fruit
Canned Vegetables
Dry Crackers
Dried Potatoes
Tuna, Salmon & Chicken in pouches
Vegetable Soup
Canned Fruit
Fruit Juice
Cereal
Peanut Butter
Jelly
Nuts
Chocolate Bars
Vegetable Oil
Pasta
Multivitamin
Pet Food
Soap
Prescription medications

Even if the bird flu never comes, it’s good to have a lot of these items on hand in case of any type of emergency. Just buy things your family likes and rotate your stock on a regular basis.
 

New Freedom

Veteran Member
http://www.un.org/apps/news/story.asp?NewsID=18004&Cr=bird&Cr1=flu


Bird flu: countries must share information despite fears of short-term losses – UN

30 March 2006 – Some countries worry that sharing information about bird flu will affect their economies, poultry industry and tourism business, but transparency is still the long-term solution for those concerns, a senior United Nations point man in the fight against the disease said today.

“It’s a very tricky issue,” the UN System’s Coordinator for Avian and Human Influenza David Nabarro, told UN television in an interview when asked how such fears could be eased. He cited Viet Nam as a good example of the policy that speedy transparency benefits the long-term economic interest.

Timely information-sharing is vital in mobilizing resources to contain the H5N1 bird flu virus which has so far spread out of Asia into Europe, the Middle East and Africa, leading to the deaths or culling of more than 150 million birds. Experts fear that in a worst case scenario it could mutate into a deadly human pandemic.

“You can’t reassure a country, a government that if they share information, that it won’t necessarily mean that in the short term at least they will feel some pain, they may have a reduction in tourism, they may have a reduction in the willingness of other countries to buy their poultry,” Mr. Nabarro said.

“But, I’ve talked to the Deputy Prime Minister of Viet Nam, for example, and he said to me: ‘We know in Viet Nam we have to be open because we want our tourism industry so stay strong in the long term. Tourists will come to our country if they trust us to be honest.

“‘If they find out that we’ve hidden something then the long-term damage to our tourist industry will be substantial, therefore we’re going to be open [with] everything we know,’” he quoted the minister as saying.

Secretary-General Kofi Annan yesterday made an impassioned plea for greater funding beyond the $1.9 billion already pledged to help poor countries, above all in Africa, to fight bird flu. “We know that H5N1 avian influenza can be controlled if outbreaks are identified quickly, infected animals are culled, and movement and marketing of poultry are stopped in outbreak areas,” he said.

“But such measures can succeed only if communities and animal health authorities work together, if we keep the public informed about risks and the means to reduce them, if we monitor progress carefully, and if we provide swift and adequate financial compensation for culled birds,” he added of the need to prevent fear of lost livelihood from impeding speedy reporting of the disease.
 

New Freedom

Veteran Member
http://www.recombinomics.com/News/03300601/H5N1_Azerbaijan_Cluster_Grows.html


H5N1 Bird Flu Familial Cluster in Azerbaijan Grows

Recombinomics Commentary
March 30, 2006

Five young people, three of them from the Askerov family, have died from bird flu in Azerbaijan. But the girl, who is now in hospital, is the first new case of suspected infection since the first week of this month.

Velibeyov said the girl had probably caught the virus via the same route as her other family members, who are thought to have been infected while plucking feathers from dead swans.

The above comments on another H5N1 bird flu case in the Askerov family raise additional concerns about WHO assurances and analysis. In addition to three family members who have died, a close friend was also fatality infected with H5N1. Comments on the origin of the infections fail to account for infections over an extended time frame.

The index case in the cluster died on Feb 23. Her cousins and friend died between March 3 and March 10. Now a fifth person has been hospitalized and is still alive on March 30. The extended time frame of this cluster is more consistent with human-to-human transmission than a common source that produces disease over such a long time frame.

Human-to-human transmission of H5N1 among family members is quite common and is linked to the majority of reported cases. The size of these clusters increased dramatically in Turkey. S227N was isolated from the index case in that cluster, raising the possibility of genetic changes that increase the efficiency of human-to-human transmission.

That cluster was geographically close to the current cluster in Azerbaijan and raises the possibility that this change or a similar change has increased the efficiency of H5N1 to humans. The transmission of H5N1 to a human cluster over an extended time frame is cause for concern.
 

New Freedom

Veteran Member
http://english.pravda.ru/news/world/31-03-2006/78127-birdflu-0

Two more people hospitalized with bird flu in Azerbaijan


Azerbaijan's health officials said Thursday that two more people had been hospitalized with bird flu in the ex-Soviet Caspian Sea nation, where the disease has claimed five lives so far.

Health Minister Oqtay Shiraliyev said that four of the five victims, who died earlier this month, were residents of one village, and three were members of one family. He said at a news conference that the victims apparently had contracted the deadly H5N1 strain of bird flu when they were plucking feathers from dead swans.

Shiraliyev's deputy, Abbas Velibekov, said two sisters from the same family, a 15-year-old and a 16-year-old, were hospitalized with bird flu symptoms. Their blood samples were sent to a London laboratory for a confirmation of the diagnosis, he said.

The outbreak in Azerbaijan was first detected last month in wild birds along the Caspian Sea coast. It has spread to the northeast and the southwest, near the border with Iran.

Azerbaijan shares a short border with Turkey, where four children died recently of the disease.

The World Health Organization said at least 105 people died from H5N1 since 2003. Almost all of the human deaths have been linked to contact with infected poultry, but experts fear H5N1 could mutate into a form that spreads easily among people, sparking a human flu pandemic, reports AP.

According CBS News, an experimental bird flu vaccine seems to work. But it's nowhere near ready for prime time.

That's the word from U.S.-sponsored clinical trials of an H5N1 bird flu vaccine made by Sanofi Pasteur. The study shows that two shots of the vaccine given four weeks apart -- at the highest dose tested -- give what should be protective immunity to 50% of healthy adults.

High doses. Limited effectiveness. This means the current vaccine isn't likely to stem a deadly pandemic if the bird flu starts spreading among people.
 

New Freedom

Veteran Member
http://www.local10.com/news/8367133/detail.html

MIA Has Plan To Deal With Bird Flu Infected Passengers
Airport Has Procedure In Place In Case Of Outbreak


POSTED: 4:55 pm EST March 30, 2006
UPDATED: 5:13 pm EST March 30, 2006

Miami International Airport plays a role in the county health department's plan to prevent a bird flu outbreak in South Florida.

Part of that policy: airport officials can keep a plane from taxiing to a terminal if they think an affected passenger is aboard.


Lauren Stover, assistant MIA director, said, "We are aggressively working with our federal partners here at MIA to identify certain areas and put processes in place to address this concern."

Stover said, "We have identified an area on the airfield where we can block an aircraft and then work with the authorities to transfer the passengers to an area where they can be quarantined for whatever period of time we need to keep them."

MIA has already set aside a room that would be used as a sort of containment area for a passenger suspected of being infected. The room is in a restricted area of the airport so the passenger would never make it into the main terminal.

Some humans have been infected, but almost all after contact with birds.

The virus has shown-up in Asia, Europe and Africa but has not reached the United States.

Some international passengers say it is something they worry about, while others don't give it much thought.

Passenger Beatriz Beraud said, "Well yes, of course, mostly with children I worry. But we have to travel, so we keep on doing it... but it would be good if there was more safety."

Passenger Ken Jackson said, "It's just... I don't know. It seems too far away."

Jackson said the threat just doesn't seem real yet.
 

New Freedom

Veteran Member
Seems to be a lot more prep articles the last few days....


http://www.publicbroadcasting.net/opb/news.newsmain?action=article&ARTICLE_ID=896043


Building Your Bird Flu Preparedness Kit

By Tom Banse

OLYMPIA, WA 2006-03-30
Dick and Sarah Bullard of Olympia have stockpiled ample food stores Photo By Tom Banse

The looming threat of bird flu is causing emergency planners to rethink some of their advice.

You've no doubt heard for years now that you need to be prepared to survive on your own for three days after a natural disaster. In a flu pandemic, you could well have to hold out longer. Correspondent Tom Banse has the updated thinking.

-------------

John Wiesman: "'Social distancing' is a very simple concept. Basically, it's about how do you limit the amount of face-to-face contact with other people. How do you avoid being in crowds."

Officials like Clark County Health Department Director John Wiesman agree: Good hygiene and keeping several arms-lengths away from other people will be primary flu control strategies.

John Wiesman: "You might close down school or ask movie theaters or places where there would be large crowds to not open...cancel sporting events."

Wiesman says a good analogy would be an extended "snow day." You'll want to build up your emergency stash accordingly.

John Wiesman: "If you're one of the those who already had three days of supply, start working towards something longer, maybe as much as two weeks."

With officials like Wiesman saying the disease could well disrupt commerce and services in your town for six to eight, or even twelve, weeks, how do you prepare? We asked one group that knows -- the Mormons.

(Sound of a crowd in a church hall.)

Members of the Church of Jesus Christ of Latter-day Saints in Olympia annually hold a preparedness fair.

Congregation leader John Anderson says readiness and self-reliance have long been tenets of the Mormon faith.

John Anderson: "We talk about home storage and family preparedness that goes up to a year. Depending upon what the circumstance might be, your family may be in need of basic food supplies and water for a longer period of time. Whether that be a job situation or a disaster or whether it be a pandemic or an epidemic."

There's no mention of bird flu at any of the displays that line the church hall. But there doesn't need to be, because the same advice applies for all kinds of disasters.

A married couple, Dick and Sarah Bullard, have barrels and plastic buckets of dry goods stacked five high against one wall of their garage.

Dick Bullard: "The church says hey, for a person to live he needs so much wheat, and so much honey, salt, and so much water for a period time. We tried to match with that."

(Sound of a thump on a barrel.)

Dick Bullard: "There's a big barrel with 350 pounds of wheat in it. So there's probably four, five hundred pounds right there. These have dried corn in them that we could grind and make corn meal if we wanted to. And some water there (taps on barrel). Then some pinto beans and there's some Great Northern Beans here someplace."

Sarah Bullard: "Yeah, it'll be a hardship. We'll all miss our Twinkies and Ho-Hos and Oreos. But we're living you know, and that's the basic point."

The Bullards' six kids are all grown up, so they'll be spared the challenge of keeping a cooped-up household peaceable. Other congregation members have stashed toys, games, and homework.

Of course, entrepreneurs are swooping in to help the less prepared, even though bird flu has not appeared in this country and the virus is presently incapable of rapid human-to-human transmission.

In Oregon City, website operator John Hart says he's doing a brisk business selling facemasks coated with a "viruscide." They start at three for 89 bucks.

John Hart: "You don't need to wear a mask in the house, but if you go outside you surely better be wearing something, because we will not know who is sick and who isn't."

John Hart: "So I think it's a valuable investment. It's a piece of insurance. Look at it that way. You gotta have something. What if it comes, and you're caught with nothing? Do you really think all the masks that are out there will still be there? I doubt it."

Public health experts are quite dubious about bird flu survival kits sold on the internet. But a surgical mask could be an item to add to your emergency kit anyway. That's because if you start hacking and coughing, it can prevent your germs from landing on someone else.
 

PCViking

Lutefisk Survivor
Hunters told to take precautions against bird flu transmission
3/31/2006, 12:15 a.m. PT
The Associated Press

MEDFORD, Ore. (AP) — Oregon waterfowl hunters might find themselves on the frontlines of the fight against an avian flu outbreak in North America.

Birds founds in this region are known to mix in Alaska with birds from Asia, where the virus is most prevalent, leaving birds migrating through the western U.S. to be considered one of the virus' possible routes to America.

Waterfowl experts are warning hunters to take due precautions as a result, from wearing gloves when field-dressing waterfowl to dousing knives with a bleach solution when done. They are also advising hunters to clean and disinfect decoys and waders if hunting in waters where the virus is found.

Hunters are also being told to provide samples waterfowl they've killed for testing, and to ensure that all waterfowl are fully cooked before eaten.

"It's like (hurricanes) Katrina and Rita," spokesman Gregg Patterson of the Tennessee-based Ducks Unlimited told The Medford Mail-Tribune. "You realize we're not insulated against this kind of stuff. What everybody needs to do is prepare for it."

Avian Influenza, or AI, is a set of viruses that are naturally found in wild birds, particularly waterfowl and shorebirds that normally suffer no ill effects from them. However, domestic birds like chickens are generally more susceptible.

But the H5N1 strain now found in 41 countries in Asia, Africa and parts of Europe is frequently fatal to birds and easily transmissible between species. To date, scientists' ultimate fear is that the virus will mutate into one that directly affects people as well as be passed among humans.

The National Wildlife Health Center in Wisconsin says as of mid-March, the H5N1 virus has sickened 177 people and killed 98, mostly in Cambodia, China, Indonesia, Thailand and Turkey. Most of those were infected from eating or handling infected chickens.

Just the mention of avian flu has scared some Oregonians out of waterfowl hunting, said Brad Bales, waterfowl biologist for the Oregon Department of Fish and Wildlife.

"I got, maybe, a dozen calls (last season) from hunters who said their families won't let them hunt anymore because of avian influenza," Bales said.

Oregon expects to receive about $400,000 in federal funds for various sampling efforts beginning in the fall, Bales said.

Cackling Canada geese, a priority species, will be tested by sampling birds at hunter check-in stations in Northwest Oregon, where they concentrate, Bales said. Other species, such as shovelers, pintails and green-winged teals, could be tested elsewhere in the state, he said.

http://www.oregonlive.com/newsflash...news-14/114379381963200.xml&storylist=orlocal

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JPD

Inactive
Israel...

Bird flu identified in Kerem Shalom

http://www.jpost.com/servlet/Satellite?cid=1143498774623&pagename=JPost/JPArticle/ShowFull

By JPOST.COM STAFF

Mar. 31, 2006 12:42 | Updated Mar. 31, 2006 11:44

Kibbutz Kerem Shalom began culling its 20,000 turkeys on Friday after the deadly bird flu virus was positively identified there earlier in the day.

The kibbutz is located near Kibbutz Holit, one of the first kibbutzim in which the lethal strain was positively identified two weeks ago.

Just on Wednesday the lethal strain was discovered in the Jerusalem-area kibbutz of Ma'aleh Hahamisha, and their poultry were culled as well.

Earlier in the week, sources in the Ministry of Agriculture asserted that the virus had been eradicated from Israel, Army Radio reported.

On Sunday, Agriculture Minister Ze'ev Boim noted that Israel took action more quickly than other countries in the world faced with a flu outbreak.

Briefing the cabinet on how Israel combated the flu, he said that in nine days some 1.2 million poultry from 53 chicken farms in 14 different communities were destroyed and buried.
 

JPD

Inactive
Bird-Flu Pandemic, Even Mild One, Will Overwhelm U.S. Hospitals

http://www.bloomberg.com/apps/news?pid=10000103&sid=a4LQlizkeMqo&refer=us

March 31 (Bloomberg) -- In 1957, the University of North Carolina turned a dormitory into a hospital for dozens of students stricken by an Asian flu circling the globe. Eleven years later, Nashville medical centers filled beyond capacity when another worldwide epidemic hit.

The famous 1918 Spanish flu that killed 50 million people isn't the only pandemic that caused a global health crisis during the past century. Two other pandemics, though much milder than the more well-known one, also strained nations' health-care systems, researchers say. The Asian flu killed at least 2 million in 1957, and about 700,000 died during the Hong Kong flu in 1968.

If the current wave of bird flu turns into a human infection that is only as widespread and deadly as the one in 1968, the American health-care system will be severely tested, said Nancy Cox, head of the Centers for Disease Control and Prevention's influenza branch in Atlanta. ``Emergency rooms would be overflowing, doctors offices would be overflowing and hospital beds would be overflowing,'' she said March 20.

An outbreak roughly equivalent to the Hong Kong flu might kill only about 209,000 worldwide as a result of new medicines and improved care, U.S. health officials estimate. Yet, a bird- flu pandemic similar to the one that hit almost 40 years ago is almost certain to be catastrophic, perhaps sickening one in three Americans and over-burdening the nation's 4,000 hospitals, 20 percent fewer than in 1968, health officials predict.

U.S. hospitals are ``simply not set up to accommodate'' illness rates of up to 35 percent, levels seen in past pandemics, CDC's Cox said. Even in the most-severe seasonal flu outbreaks, illness rates top out at 15 percent of the population, said William Schaffner, an infectious-disease specialist at Vanderbilt University School of Medicine in Nashville.

Spreading Among Birds

The H5N1 avian influenza has spread among birds throughout most of the Eastern Hemisphere since late 2003 and threatens to reach North America this year, health officials say. The disease has already infected 186 people, almost all through direct contact with birds, killing 105 of them, according to the World Health Organization.

Scientists worry the virus may mutate into a form transmissible from human-to-human that could travel around the world in days to weeks. A lethal virus spreading this way might kill millions of people worldwide, while halting shipping, transportation, trade, agriculture and other important activities, researchers have forecast.

Even if the flu comes in a relatively mild form, emergency rooms would be first to be flooded with pandemic flu cases, said Andrew Bern, a physician at Delray Medical Center in Delray Beach, Florida.

`Close Off Access'

Health authorities will have to ``close off access to care'' for patients who use emergency rooms for colds, children's ear infections, cuts and broken bones, said Bern, who founded the American College of Emergency Physicians' disaster medicine section.

Emergency care in the U.S. is ``like a house of cards,'' he said, ``waiting for a big wind to collapse it.''

Visits to U.S. hospital emergency rooms rose 26 percent to 114 million in the 10 years ending in 2003 as the population increased, Bern said. During the same period the number of emergency rooms fell 14 percent due to cost-cutting by medical centers, said David Seaberg, a director with the Physicians' College, in Feb. 8 testimony before the House Committee on Homeland Security.

Limits on Life-Saving Technology

The demands of a pandemic may limit the availability of life-saving technology for such things as lung diseases, Minnesota scientists said in a Jan. 6 study in Academic Emergency Medicine. If only 10 percent of the 2.6 million people around Minneapolis were infected, the city would quickly run out of ventilators that help patients breathe, said John Hick of Hennepin County Medical Center and Daniel O'Laughlin of Abbott Northwestern Hospital.

David Costello and Paul Glezen have vivid memories of the Asian flu pandemic in 1957, and Vanderbilt's Schaffner easily recalls the 1968 Hong King outbreak.

A fever of 101 wasn't high enough to rate entry into the University of Notre Dame infirmary in 1957, when Costello, then a 19-year-old sophomore, got hit with the Asian flu pandemic.

Sick students lay on hallway cots at the South Bend, Indiana, college as they did in clinics and hospitals throughout that region, said the 69-year-old Costello, now a retired history teacher in Buffalo, New York.

During that same outbreak, the University of North Carolina in Chapel Hill converted a dormitory into a hospital for Asian flu-stricken students, said Paul Glezen, 75, a Baylor University epidemiologist and a public health worker in 1957.

Makeshift Hospital

The makeshift Chapel Hill hospital ``was just for the students who lived too far away to go home,'' Glezen recalled. ``It was only a fraction of the kids who were really ill.''

In 1968, Nashville hospitals that normally had beds to spare were filled to capacity, said Schaffner, who now consults to the U.S. government on flu issues. Schaffner said he caught the flu caring for patients a day after running a dangerous 103-degree fever.

``There was concern that people being admitted were acquiring flu in the hospital,'' he said in a March 10 telephone interview. ``Every hospital was full and there were patients waiting in the emergency rooms.''

Today, U.S. hospital officials say reductions in capacity mean even small increases in patient volume can stress a community's health services. Regular seasonal flu outbreaks force most New York City area hospitals to divert or limit emergency room admissions for part of the year, said Nathaniel Hupert, assistant profess of public health and medicine at Weill Cornell Medical College in New York.

Mutation Unclear

``Our U.S. hospital system gets crushed in a normal flu year,'' he said in a March 16 interview.

It remains unclear, though, whether H5N1 will change into a form that transmits among humans easily enough to cause a pandemic, said Cox, the CDC flu branch head. Even if bird flu become contagious to people, it may do so by exchanging genes with seasonal influenza virus the human immune system is already familiar with, making a mild pandemic more likely, she said. The Spanish flu was so deadly because it was a virus the immune system hadn't encountered before.

``You have to prepare for the worst, but it's entirely conceivable that we could have a moderate one,'' Anthony S. Fauci, 65, head of the Bethesda, Maryland-based National Institute of Allergy and Infectious Diseases, said in a March 10 telephone interview. ``You have to prepare for a horrendous problem, but the general public shouldn't assume that we're going to see the worst case.''
 

JPD

Inactive
Get ready for flu pandemic, U.S. health chief warns

Posted on Fri, Mar. 31, 2006

http://www.contracostatimes.com/mld/cctimes/news/local/states/california/14230291.htm

Leavitt says communities should not depend on federal or state governments if there is an outbreak of avian flu

By Alicia Chang
ASSOCIATED PRESS

LOS ANGELES - The nation's health chief said Thursday that communities need to brace for a possible flu pandemic and not solely depend on the state and federal government to bail them out if an outbreak occurs.

Health and Human Services Secretary Mike Leavitt said that while a pandemic was not imminent, local governments and businesses still need to prepare for the possibility. Leavitt stopped in Los Angeles on nationwide tour to step up preparation plans.

"When it comes to pandemics, we are overdue and underprepared," he told a gathering of public health officials and emergency first-responders at a downtown hotel.

The government has earmarked $6.7 million to California to strengthen disease surveillance, buy protective gear and conduct training exercises. Los Angeles County will receive nearly $3 million of the federal money.

Gov. Arnold Schwarzenegger has proposed $27 million in state funding for flu pandemic planning, including the purchase of more than 270,000 doses of the antiviral Tamiflu.

Fear of a pandemic has increased as the bird flu virus has rapidly spread in poultry from Asia to Europe, Africa and the Middle East.

While bird flu has not yet appeared in the United States, the government last week warned that the virus could arrive this year and boosted its effort to look for the virus in migratory birds.

Even if bird flu started killing poultry stocks in the U.S., experts say it won't be a crisis until the virus mutates into a more lethal form. So far there's no evidence of the virus changing into a dangerous type.

The government is working under the worst-case scenario that up to 90 million Americans would become sick with the virus and 2 million would die during a worldwide flu pandemic.

Leavitt said it would be impossible for states and the federal government to rush to the rescue of thousands of communities at the same time in the event of a crisis.

More than 180 people worldwide, mostly in Asia, are known to have been infected with the H5N1 bird flu virus since 2003. More than 100 have died.

Virtually all the victims who have contracted bird flu have had close contact with infected birds and there's no evidence the virus is easily transmitted from person to person.

Anticipating the arrival of bird flu, the U.S. plans to test 75,000 to 100,000 wild birds for the virus and quarantine and destroy any infected poultry flocks.

Scientists have long warned that the virus could mutate into a version that spreads easily.

Governments around the world are stockpiling antiviral drugs to lessen the severity of bird flu. The U.S. goal is to stockpile enough medication to treat a quarter of the population.

ON THE WEB:

Bird flu page: http://www.pandemicflu.gov
 

JPD

Inactive
H5N1 Pandemic Vaccine Progress Well Shy of Half Empty

http://www.recombinomics.com/News/03310601/H5N1_Vaccine_Half_Empty.html

Recombinomics Commentary
March 31, 2006

The recent New England Journal of Medicine article on results of the US pandemic vaccine trial has been described in some media accounts as half full (half of the subjects responded) or half empty (half of the subjects failed to respond). However, the data are well shy of the half empty description.

The results were really telegraphed in August 2005 when initial results were announced. Although the “we have a pandemic vaccine” was technically correct, the description of the initial results made it clear that the responses were far from ideal. The best responses were in subjects receiving the highest dose and two shots were required. Thus, the amount of antigen was 12X the level used for a single target in the seasonal vaccine. This alone would produce a serious production problem, because there were anticipated problems using just 1/12 of the amount. The problem was also worse than simply the dosage requirement for two injections, because a third injection was mentioned. This indicated that many failed to adequately respond to two injections. Three injections using 18X the expected amount was projected to be VERY unworkable. In addition to taking 2 months to complete a vaccination course, the amount of antigen required would severely limit the number of subjects that could be immunized.

Moreover, the end point was a titer of 40, which was no guarantee that patients would not get infected. There was no “challenge” top shop that a titer of 40 was sufficient to prevent infection of death. The minimal immunity might allow the patient to live for two weeks instead of one, but the outcome would still be the same. Alternatively, the patient might recover, built with permanent neurological damage. A titer of 40 is a borderline response. As shown in the NEJM data, a background titer of 10 is present in the placebo controls and even a titer of 20 can be due to nonspecific factors.

Data from the 1918 pandemic indicates that those who survived had titers above 1000, and these titers were present in 2005, over 85 years after the pandemic. Thus, titers of 40 may simple delay the inevitable and produce additional strain on medical facilities. Therefore, titers of 40 or more in half of the young healthy adults were well shy of a half empty description.

In addition to the low titer and production issues, the changing specificity was yet another issue. When the trial began, only Vietnam and Thailand were reporting human H5N1 cases.. The sequences from these isolates were similar, so one vaccine could protect against both H5N1 versions. However, last summer it was clear that H5N1 was evolving away from the 2004 H5N1 target sequence from Vietnam. H5N1 was being transmitted and transported by wild birds and it was just a matter of time before these sequences also caused human cases. In 2005 human cases in Indonesia and China were reported, and sequences from these areas suggested that the cross reactivity between H5N1 from Vietnam/Thailand and Indonesia/China would be poor and the Qinghai sequences were distinct from all of the above. Now the Qinghai strain has cause human fatalities in Turkey, Iraq, Egypt, and Azerbaijan highlighting the need for multiple vaccines.

Sequence analysis indicates these H5N1’s are evolving via recombination and therefore new versions of H5N1 can be predicted. However, these predictions are dependent on the sequences of the circulating strains of H5N1 and much of the most recent data is sequestered in a private WHO database. WHO announcements that H5N1 is evolving via “random mutations” indicates their advice is fatally flawed and the sequestered sequences are not being properly analyzed.

Release of the sequences are a review of WHO’s actions are long overdue.
 

JPD

Inactive
FT. DODGE ANIMAL HEALTH ANNOUNCES LICENSURE OF A REVERSE GENETICS AVIAN FLU VACCINE

http://www.agrimarketing.com/show_story.php?id=39366

Mar. 31, 2006

Fort Dodge Animal Health, a division of Wyeth, today announced the National Agency of Veterinary Medicine (France) has given temporary approval for Poulvac(R) FluFendTM i H5N3 RG, an inactivated virus reverse genetics avian vaccine to aid in the prevention of avian influenza (AI) caused by the H5N1 virus.

In collaboration with St. Jude Children's Research Hospital and the University of Wisconsin, Fort Dodge developed the vaccine as part of a control and eradication program in response to the growing concern about global avian influenza and the need to protect poultry from the disease.

Reverse genetics, a cutting-edge technology being utilized in the development of human vaccines, has enabled Fort Dodge to take components from three different influenza viruses and bring them together in a single product. This technology, licensed from the Wisconsin Alumni Research Foundation, not only results in a product that offers safe and effective protection against the most prevalent strain of AI currently threatening France, but also allows for differentiation between a field strain and the vaccine, using diagnostic tests that Differentiate Infected from Vaccinated Animals-the so-called DIVA system. DIVA is often used as part of a monitoring program to demonstrate the flock is not infected with the field virus.

The reverse genetics technology used for the preparation of the Fort Dodge H5 influenza vaccine was developed by Erich Hoffmann, Ph.D., Division of Virology, St. Jude Children's Research Hospital. This process, known as the eight plasmid reverse genetics system, is a significant advantage for future poultry vaccines because it allows the antigen content to be standardized, according to Robert Webster, Ph.D., holder of the Rose Marie Thomas Chair, Department of Infectious Diseases, at St. Jude. "The standardization of antigen content is similar to human influenza vaccines, and more recently for equine influenza vaccines," Webster said. "Thus, this new vaccine is a major advance for preventing infection of poultry with H5N1."

The French Ministry of Agriculture and Fisheries has requested an initial supply of 7 million doses of this vaccine for use in ducks as part of an avian influenza control program. Approval was based on the efficacy of the vaccine, which demonstrated the ability to reduce mortality, virus re-isolation and shedding after challenge with highly pathogenic AI viruses. The French Ministry recently started vaccinating outdoor ducks in parts of France, as authorities consider these areas at high risk for the transmission of AI virus by migrating birds.

As part of AI control programs, various Fort Dodge conventional vaccines have been registered or used in other parts of the world to provide safe and efficacious protection against Avian Influenza. In several different countries, Fort Dodge's products have been supplied as vaccine banks for use in the event of an outbreak. In addition to H5N3 RG, Fort Dodge has approvals for vaccines including H5N9, H5N2, H7N1, H7N2 and H7N3 strains.

Source: PRNewswire
 

JPD

Inactive
AFRICA: GLOBAL: Interview with David Nabarro, UN coordinator for avian flu

http://www.irinnews.org/report.asp?ReportID=52531&SelectRegion=Africa&SelectCountry=AFRICA

[ This report does not necessarily reflect the views of the United Nations]

© IRIN

Dr David Nabarro of WHO

NAIROBI, 31 Mar 2006 (IRIN) - David Nabarro, the United Nations coordinator for avian and human influenza, attended a conference in Libreville, Gabon, on 20-21 March, where representatives from 46 African countries, the UN and the donor community discussed a response to avian influenza. With the highly pathogenic H5N1 avian flu detected in Niger, Nigeria, Cameroon and Egypt, Nabarro told IRIN that African nations were taking the challenge very seriously.

QUESTION: You’ve just returned from Gabon. Are you optimistic or concerned about the state of local capacity, available funding and the ability of local actors to contain avian influenza in the region?

ANSWER: The meeting in Gabon was extraordinary, because of the degree to which officials - and there were very senior officials and ministers from African nations - have come together to focus on the nature of the challenges they face. Despite the fact that they are dealing with many other development crises at the moment, despite the fact that many of them are in countries affected by instability, they didn’t come saying, “We can’t yet have another difficulty to deal with.”

They came saying, “We know we have potential problems ahead; we know we are dealing with real problems now, and we need to focus on how best to deal with these.” I think they recognised that there is not a big bucket of money somewhere that it is going to be accessible to quickly implement these new activities. Instead, they are recognising that they need to prioritise; they need to use existing resources to deal with the avian infection and to prepare for a potential pandemic.

The potential humanitarian consequences of both the avian infection and the pandemic are clearly understood by the governments concerned. For example, we’ve seen the Nigerian government addressing the issue by looking for vulnerabilities and trying to provide relief to communities that are affected.

And it was good to have OCHA [UN Office for the Coordination of Humanitarian Affairs] engaged in the Gabon meeting, communicating - both in the main plenary and in private discussions with representatives - that humanitarian experience was on offer to help deal with some of these potential and major problems associated with the avian disease and the potential pandemic.

Q: Are you suggesting that a lot can be done with minimal resources and through prioritisation? Are there low-cost solutions for addressing avian influenza?

A: In real life in a developing country, the majority of actions that are taken to deal with a new problem are not primarily funded through external assistance. It’s always a team of national officials, of community leaders and the resources that are available to them, that are the primary fuel for their activities. The external assistance comes in and helps out, but I have to keep reminding people that the majority of the resources come from the people and the communities of that country.

There are measures going on already in African nations. They are going to be using preparedness of the kind we have seen for other crisis situations. Part of the discussion was on what are the triggers; what are the priorities; how to work with communities, so they can be at the centre of the response; and how to draw on standard disaster preparedness, based on prior action with the UN. I think that’s the right way to go.

Q: Is avian influenza going to have the greatest impact in countries that are already affected by drought, crisis and HIV/AIDS? Or, do you expect that a broad humanitarian presence, in places such as the Democratic Republic of Congo, will be able to effectively counter the disease and pandemic?

A: I think that the ease with which any country is able to deal with a stress like avian influenza is entirely dependant on the capacity of the authorities in that country to carry through and ensure the implementation of quite complex programme activities. That applies whether it’s a national government or whether it is a government structure that is strongly reinforced through international assistance. Where capacity to implement is strong, then the results will be good. Where capacity to implement is not so strong, then it is going to be much more difficult.

Q: Are you satisfied with the US $1.9 billion that was pledged [at the International Pledging Conference on Avian and Human Influenza in Beijing in January] to tackle avian influenza?

A: A lot of colleagues have said to me, “Surely $1.9 billion is such a lot of money that there will be plenty to go around for all the countries concerned.” My response is, let’s look at that $1.9 billion. It’s a pledge. It’s not an actual set of grants. It’s a pledge of loan money that can be obtained through the procedures by which governments obtain loans. These are not actually straightforward, and they have to go through an appraisal. Twenty-two countries are having their plans appraised before they can get hold of the loan.

The other billion or so is grant money, and a lot of that is linked to particular programmes or agencies that are high priority. Some of it is also linked to regions of the world that are known to be in need, particularly Asia.

So accessing these resources is possible, but it’s not a simple process of a government [requesting] $100 million and the money being available the next day. There is a process of dialogue, negotiation and investigation that has to take place because these are complicated activities being implemented.

I do think that we would need in due course a special window through which African nations can access resources -with technical assistance, with operational support - to help them to deal with some of these issues. That was discussed in Gabon, and it’s going to be discussed again over time. Either that will come out of the existing $1.9 billion, or it may be necessary to supplement a bit. All this is still in the midst of discussion. I’m pleased to report to all potential donors that I did see signs that African nations were taking their challenges seriously and in a timely manner.

[ENDS]
 

JPD

Inactive
UK...

'Mass grave' a possibility for victims if flu strikes'

http://iccroydon.icnetwork.co.uk/ne...ty-for-victims-if-flu-strikes--name_page.html

Mar 31 2006

VICTIMS of a flu pandemic in Croydon could be buried in a mass grave if the illness hits council workers.

A report into how the town would deal with a flu pandemic on the scale of the one that struck after the First World War has put the number of potential fatalities at 8,000 - with a quarter of the town's 330,000 population becoming infected.

A report drawn up by the council says the number of people dying would increase from 45 to more than 400 a week. At peaks this would mean the crematorium running 24 hours a day to cope and the council employing eight teams of gravediggers.

If the contingency fails, either through excessive staff sickness or through the failure of power supplies, "then the plan falls back on the use of a mass grave," the report says.

It adds: "This will only be used as a last resort as it poses many moral and psychological challenges."

Cllr Paul Smith, cabinet member for public protection and crime reduction, said: "This plan is not intended to scare anyone, quite the reverse. It is about saying we recognise the risk that exists and we are working with other London boroughs to make sure that whatever happens we are there to meet it."

The plan looks at a general flu pandemic but it leaves the council prepared to deal with an out-break if bird flu hit humans.
 

moocollins

Rider of the storm!
THE REAL BIRD FLU DANGER

THE REAL BIRD FLU DANGER
by Mark Tier

http://www.dailyreckoning.com

The Spanish flu pandemic of 1918 killed 25 to 50 million people - 2.5%
and
5% of the world's population. If you believe fear-mongers writing for
the
world's media, the supposedly virulent H5N1 bird flu virus will cause
another pandemic any day now. If it's as bad as 1918, 125 to 300
million
will die. With 747s, instead of the more leisurely steamships of 1918,
any
pandemic will spread a lot faster today so the death toll could
possibly
reach a billion people.

A terrifying prospect, isn't it?

But major differences - aside from 747s - between 1918 and now mean
that
the real chance of another 1918-style bird flu pandemic, while not
zero,
is pretty close. To start with, in 1918 scientists didn't even know
what a
virus was. They knew that the Spanish flu was caused by something
smaller
than bacteria - but until the 1940s no one could see or isolate a
virus,
let alone analyze one.

Today not only do we know what viruses are, we have developed some
protection against them; and scientists can decode their genetic
sequence.
Secondly, the Spanish flu came out of the blue, so to speak. There was
no
warning - nor did anybody expect it. By the time people realized it was
a
pandemic, it had already spread worldwide.

Today, in contrast, everybody expects a pandemic to begin any day, and
health authorities everywhere are already planning what to do. (Let's
just
hope their preparations will be more effective that their planning for
catastrophes like hurricane Katrina!)

But remember SARS? It appeared from nowhere in 2002. And who expected
something like it? Not a soul. Yet, just days after it was first
identified as a new and unknown disease, sufferers and their contacts
were
quarantined; travelers were screened - and so many people decided to
stay
at home that airlines like Hong Kong's Cathay Pacific suffered dramatic
declines in passengers - and profits.

Within just a few weeks, SARS had been identified as a corona-virus,
and
soon thereafter its source was traced to civet cats in China's
Guangdong
province. SARS, while not as contagious as influenza, was pretty nasty
just the same. Almost 10% of the people who caught it died. Ironically,
though, so effective were the measures taken to isolate sufferers that
over 20% of the people infected were doctors, nurses and other hospital
staff - who caught it from patients!

This totally new, virulent but unknown and unexpected disease - spread
around the world almost instantly by 747s - killed a total of 774
people.
Thousands more people die from diseases like malaria and dengue fever
every year.

Unlike SARS and the Spanish flu, the world now expects a disastrous,
world-wide influenza pandemic to happen any day. So everybody's
watching
for it. The moment someone catches the H5N1 virus from a bird, they're
isolated. Birds carrying the virus are being culled in the millions -
further reducing the chances of it mutating into something that can
jump
from human to human.

However, as the British Medical Journal put it in its October 29 issue:

"The lack of sustained human-to-human transmission suggested that this
H5N1 virus does not currently have the capacity to cause a human
pandemic," adding that the warnings are entirely a theoretical
speculation.

Is there any evidence for this conclusion? To judge from the press,
this
H5N1 avian flu virus is something new. Maybe it isn't. What is
certainly
new is that every time someone catches it, it's on the front pages of
the
newspapers.

Dr. Jeffery Taubenberger - a molecular pathologist with the Armed
Forces
Institute of Technology in Washington, D.C. - led the research team
that
recently decoded the 1918 Spanish flu virus.

What they discovered: it was not H5N1 - or any other known avian flu
virus. What's more, though definitely bird flu, it didn't originate in
chickens, ducks or geese. In fact, nobody knows at the moment what bird
it
came from. As part of their research, Taubenberger and his team
analyzed
tissue samples from 25 preserved waterfowl, vintage around 1918, stored
at
the National Museum of Natural History in Washington.

They discovered that avian flu viruses those birds carried were
identical
to same variants found in birds today. In nearly a century, these
viruses
have hardly changed or evolved at all.

To people used to taking a flu shot every year - because last year's
flu
shot won't protect you against this year's flu - this may seem a
surprising discovery. But human influenzas are continually evolving -
as
the virus gains resistance to each new medication. As birds don't take
antibiotics, get flu shots or other medical cocktails, the viruses they
carry don't need to change.

The H5N1 avian flu virus is known to have been around since the late
1950's. For all we know, it's been infecting people for hundreds - if
not
thousands - of years. And in all that time, it has not caused a human
pandemic. But only in 1997 did scientists actually discover it had
infected humans. As a result, today every person this virus infects is
religiously reported instead of being ignored - which turns it into a
scare, but not a pandemic.

Not everyone agrees, as we'll see in a moment. But here's something
else
that's suggestive: until very recently, only severe cases of H5N1
infection have been studied by doctors and scientists: the people who
end
up in hospital at death's door, where nearly half of them die.

So we're given the impression - fostered by the scare-mongering media
and
scientists desperate for bigger government grants - that this is an
incredibly deadly virus; one far worse than the Spanish flu.

A study published on January 9th in the Archives of Internal Medicine
casts serious doubt on this conclusion. In a province near Hanoi,
Vietnam,
where 80% of residents keep chickens and H5N1 is rampant, 45,476 were
randomly selected for a survey - 8,149 of them, or 17.9% - reported
having
had flu-like symptoms with a fever and a cough. And nearly two-thirds
of
them had direct contact with sick or dying birds.

While blood-testing needs to be done to confirm the hypothesis, it
seems
highly probable that the H5N1 strain of avian flu is very similar to
the
other viruses birds carry: capable of infecting humans but with very
mild
effects - indistinguishable from the common cold - when it does. Only a
tiny percent of people infected react so badly they have to go to
hospital. Until now, they were the only cases ever reported, so
creating
the unwarranted fear that H5N1 was exceptionally virulent.

Unfortunately, there is a very different bird flu danger. The H5 strain
of
viruses is just one of sixteen different virus groups birds carry
around -
rather like a flying "virus soup." As birds' immune systems are adapted
to
these viruses, they rarely get sick.

This is about to change.

Countries like China and Vietnam, which are among those killing
millions
of birds carrying this virus, are inoculating them as well. So the H5N1
virus - not to mention all the other viruses birds carry around with
them
- will soon gain resistance to current treatments (like Tamiflu).

Indeed, the New Scientist recently postulated that the H5N1virus could
well be the result of past inoculations of domestic fowl. While the
latest
evidence suggests they were wrong, there is no doubt that thanks to
these
inoculations H5N1 could easily evolve into an entirely new strain,
already
resistant to all known treatments.

If that happens, even if it doesn't jump to humans it could easily
decimate the world's bird population. That said, it is possible that
the
H5N1 virus - or one of the other many such viruses birds carry with
them -
could jump to humans. After all, that's how both the "Asian flu"
(1957-58)
and "Hong Kong flu" (1968-69) got started. If that happens, what's the
best protection?

The Spanish flu pandemic gives us the answer (and it's not Tamiflu).

One of the countries least affected by the Spanish flu was a country
that
has long had exceptionally strict quarantine laws: Australia, but not
as
strict as American Samoa. As telegrams carried the news faster than
steamships, American Samoa knew about the Spanish flu long before it
arrived there. They simply closed their doors, and did not let any
ships
dock except under strict quarantine conditions. The number of deaths
from
Spanish flu in American Samoa: zero.

But the Spanish flu did hit Western Samoa, just a few miles away, where
there was no quarantine: some 20% of the population died.

That SARS didn't turn into a pandemic is further proof of the
effectiveness of quarantine in stopping a highly contagious disease in
its
tracks. So, provided any new strain of bird flu is spotted early -
virtually certain given the current vigilance of the world's health
authorities - it will be contained long before it can turn into a
pandemic. Chances are, that's never going to happen. But even so, you
can
be sure that bird flu scares will be a staple of the world's press for
many years to come.

Why? It's simple. Last year, the George W. Bush announced an
"emergency"
$7.1 billion program to combat the bird flu scare. Other governments
around the world are setting up similar programs, though on a smaller
scale. This means we have an entirely new scientific establishment
funded
by inexhaustible government money whose sole reason for existence is to
find something that hasn't happened yet - and may never happen.

To justify their existence and to get more of that lovely government
green
stuff, you can be sure that this new "government program" will do
everything in its power to keep the bird flu scare alive. One way, is
adopting the political techniques of "spin." For example, in an article
published in Thursday's (23 March 2006) issue of Nature, Yoshihiro
Kawaoka, a researcher at the Universities of Tokyo and Wisconsin, wrote
that one reason why the H5N1 virus hasn't spread from human to human is
that it infects the bottom area of the lungs.

Other flu viruses prosper in the top of the lungs, so they're easily
spread when people cough, and even breathe out. H5N1 doesn't have that
"advantage." Nevertheless, he concludes that his findings suggest that
we
"may have more time to prepare for an eventual pandemic."

The three flu epidemics of the 20th century were caused by the H1, H2
and
H3 series of bird flu viruses. All scientists agree that the H5N1 virus
must go through many mutations before it can be spread by
human-to-human
contact. Not only does it infect the lowest part of the lungs, but it
appears that the only way a human can get it from chickens is by close
contact with lots of infected birds; the kind of thing that can happen
when you sleep with them.

So here we have a virus, which: has never, as far as we know, spread
from
one human to another; is hard to get in the first place; if someone
does
have it, is not released easily by the lungs and to the extent it is,
in
tiny quantities compared with sleeping in a chicken coop; and has to go
through a large number of unlikely mutations first in order to become a
pandemic in humans. One of those mutations, presumably, will be to
transfer its preference to the top of the lungs from the bottom,
probably
the least likely of all.

Given all these obstacles, is it science to conclude that it is only "a
matter of time" before this virus causes a human pandemic? Or is this
the
sort of "prediction" you'd expect from government-funded politicized
science where the prime imperative is not Truth but staying plugged-in
to
the government-drip machine?

And to stay plugged-in, to get the next government grant, you've got to
follow the party line, which is: a bird flu pandemic is inevitable. As
entrenched government programs are almost never axed, I expect to go on
reading that "prediction" until the day I die...of natural causes.

Regards,

Mark Tier
for The Daily Reckoning
 

Brooks

Membership Revoked
moocollins said:
until very recently, only severe cases of H5N1 infection have been studied by doctors and scientists: the people who end up in hospital at death's door, where nearly half of them die. So we're given the impression - fostered by the scare-mongering media and scientists desperate for bigger government grants - that this is an incredibly deadly virus; one far worse than the Spanish flu.

A study published on January 9th in the Archives of Internal Medicine casts serious doubt on this conclusion. In a province near Hanoi, Vietnam, where 80% of residents keep chickens and H5N1 is rampant, 45,476 were randomly selected for a survey - 8,149 of them, or 17.9% - reported having had flu-like symptoms with a fever and a cough. And nearly two-thirds of them had direct contact with sick or dying birds. While blood-testing needs to be done to confirm the hypothesis, it seems highly probable that the H5N1 strain of avian flu is very similar to the other viruses birds carry: capable of infecting humans but with very mild effects - indistinguishable from the common cold - when it does. Only a tiny percent of people infected react so badly they have to go to hospital. Until now, they were the only cases ever reported, so
creating the unwarranted fear that H5N1 was exceptionally virulent.
You're damn right it requires blood-testing (or almost any other means) to confirm this crap. This "survey" has been soundly trashed and anyone who continues to rely on it is utterly clueless. It was based on folks' recollections of whether they coughed a bit more during a certain period and focused on those folks who won't want their flocks touched because someone thinks they maybe had bird flu. More recent, and far more valid, research has shown that h5n1 is a lower respiratory disease, and very lethal.

Folks, there is no large group of mild or asymptomatic cases. Further, in a pandemic context, the current h5n1 mortality wouldn't be 50%, it would be much closer to 100%. The patients that survived on the whole required very intensive and specialized care, the type of care and equipment that will quickly be overwhelmed if a large outbreak occurs.

The only good news so far is that, for the time being, h5n1 (being lower resipratory) is not very contagious. If it makes that transition and retains any lower respiratory component, we have a LONG ways to get from 50-100% to the mere 2.5% mortality of 1918, and then a long ways to the level of season flu.
 

New Freedom

Veteran Member
http://www.mg.co.za/articlepage.asp...ing_news__international_news&articleid=268248

Israel suspects journalists of spreading bird flu
Jerusalem, Israel
31 March 2006 01:30
Israel suspects journalists, particularly press photographers, of being behind the spread of deadly bird flu in the Jewish state, an agriculture ministry official told
"It's one of our working hypotheses," the official said, asking not be identified.

"Bird flu can be transmitted on clothing, footwear, the wheels of cars and even on cameras," the official added.

"The journalists who came to cover the outbreak then went back to homes and offices across the country.

"Even if the required protective measures were taken, it is impossible to disinfect photographic equipment without damaging it."

The appearance of bird flu on a string of farms across Israel during March forced the culling of 1,2-million poultry, at a total cost, including compensation, of some $5-million.

The agriculture ministry had declared the all-clear last Sunday after that initial flurry of attacks.

But two more cases of the deadly H5N1 strain of bird flu have been confirmed in the past three days -- one at Maale Hamsha near Jerusalem and one at Kerem Shalom near the Gaza Strip.

The Palestinians have confirmed the deadly strain in poultry in the territory too.

The World Health Organization issued an urgent appeal earlier this month for Israel and the international community to provide the Palestinians with assistance in fighting it, but the issue has been complicated by the swearing-in on Wednesday of a first-ever government led by Islamic militants.

Israel has halted all exports of poultry in the face of the bird-flu outbreak. The European Union has placed a ban on imports from Israel. -- AFP
 

New Freedom

Veteran Member
http://news.moneycentral.msn.com/provider/providerarticle.asp?Feed=BW&Date=20060329&ID=5606645

Mercer Global Avian Flu Survey: Striking Gap between Employer Concern and Current Pandemic Preparedness

Mercer Human Resource Consulting:

-- Some 70% of businesses surveyed believe a pandemic would damage profitability, but only 47% have a business continuity plan in place and just 17% have budgeted for pandemic preparedness.

-- Companies in Asia are the best prepared -- 25% have established a pandemic preparedness budget compared to 12% in Europe and 7% in the US.

-- Telecommunications and pharmaceuticals companies are the most likely to have developed a pandemic preparedness budget while few retail companies have done so.

While evidence of the global spread of avian flu increases, there is a striking gap between companies' concern about the impact of a human pandemic and actual pandemic planning, according to a global survey by Mercer Human Resource Consulting.

The survey, covering 450 companies in 38 countries and 26 industries, was completed in the first two weeks of March and is believed to be one of the most comprehensive and global surveys conducted on the subject to date.

"Despite the rapid spread of avian flu worldwide and critical concerns that a pandemic would significantly affect companies' profits and productivity, Mercer's survey established that only 47% of firms have started a business continuity plan and just 17% of organizations have a pandemic preparedness budget," said Rosaline Chow Koo, head of Mercer's Health & Benefits business for Asia Pacific. "Yet some 90% of the survey participants expect a moderate to high impact to their organization from high rates of absenteeism and nearly 70% expect profitability to be adversely affected if a pandemic occurs."

Asian companies participating in the survey, particularly in Singapore, are furthest advanced in pandemic preparedness plans. "About one in four Asian survey respondents have budgeted for preparedness, compared to 12% of the respondents in Europe and 7% in the US," said Ms. Koo. "This may be because Asia is at the epicenter of the avian flu outbreak and Asian companies were directly affected by the 2003 SARS crisis."

Preparedness by industry

"A pandemic will severely impact consumer confidence, and industries that depend upon heavy foot traffic or people congregating in enclosed spaces could take a hit in a pandemic. Nevertheless, there is a gap between concern and specific planning actions to date," Ms. Koo observed.

Thus 80% of survey respondents in the hospitality and recreation sectors believe a pandemic would have a negative effect upon consumer demand and on revenue, but only 20% have established a budget for pandemic preparedness. Similarly 86% of survey participants in the transportation sector are concerned about how their revenues would be affected, but only 18% have established a preparedness budget. For the retail sector, 65% believe a pandemic would have a negative effect upon consumer demand, but only 6% of the survey respondents said their company has established a pandemic preparedness budget.

A substantial minority of respondents in four industries expect that a pandemic would increase customer demand for their businesses. In insurance, 39% of the respondents said customer demand would increase, while 36% said their company would experience a decrease in demand. In pharmaceuticals, 38% of those surveyed saw a pandemic leading to increased customer demand vs. 50% who forecast a decrease. Some 24% of respondents in telecommunications predicted increased customer demand in a pandemic, while 38% forecast a decrease. Similarly, 24% of those in health care forecast positive customer demand while 47% predicted a decrease. The balance of respondents felt a pandemic would have no effect on demand.

Hong Kong and Singapore -- equal preparation efforts, divergent forecast of impact

Mercer's survey indicates that Hong Kong and Singapore, both affected by the 2003 SARS crisis, score among the best prepared geographies for a potential pandemic. Factors taken into account include establishing a budget for preparedness, forming a crisis management team, developing a communications strategy, and undertaking a skills inventory. There is a significant divergence, however, in the expectations of respondents from these two locations of the impact on profits. Only 9% of respondents in Hong Kong expect that a pandemic would have a positive effect on their company's profitability and 80% expect a negative impact. By contrast, 22% of the Singapore respondents project a positive impact on profitability should a pandemic occur, with 56% expecting a negative effect. "This discrepancy may be due to the positive manner in which the Singapore government managed the SARS crisis." said Ms. Koo.

Europe and US preparedness

Preparedness for an avian flu pandemic in Europe and the US lacks the urgency of participants in Asia, according to the Mercer survey. "There are two key reasons for this divergence," said Ms. Koo. "First, both the US and Europe were largely spared the scourge of SARS. Second, Western Europe has experienced no human fatalities while the US bird and human populations have, so far, escaped avian flu unscathed."

"In the event of an avian flu pandemic, 80% of the US respondents expect a negative impact on their company's profits, but only 7% of these respondents said that their organizations had as yet established a budget for pandemic preparedness," said Jim Reynolds, MD, a principal in Mercer's office in Denver.

"Should a pandemic develop, however, US companies are prepared to throw money at the problem," said Dr. Reynolds. "Some 39% of US companies surveyed said they would increase pay to employees who are required to take on additional responsibility, compared to a global average of 26%. About 11% of US companies said they would increase pay for employees working from home, compared to 7% of the global respondents. We believe that, to be effective, investments are better made at the planning stage. Once a pandemic occurs, such expenditure may be seen by some employees as a bribe to risk contracting life-threatening illness. Therefore this approach is unlikely to be the most effective way to address a crisis."

"The data from Europe is less conclusive overall, but of those that replied only 12% have budgeted for pandemic preparation measures," said Charles Nelson, worldwide partner at Mercer in London. "This is probably reflective of a 'wait and see' view from European leaders. It remains important, however, that a systematic approach is taken to business continuity and planning a response to this potential pandemic."

About the Mercer Avian Flu Pandemic Preparedness Survey

The executive summary on the results of Mercer's avian flu survey can be found at www.mercerhr.com/avianflu. The web site also contains valuable resources to help employers plan for a pandemic in order to protect their employees and to ensure ongoing operations of critical business functions.

The survey was completed in the first two weeks of March 2006 by 450 companies, spanning 38 countries and 26 industries. Respondents from Australia, Canada, People's Republic of China, Hong Kong, Singapore, United Kingdom, and the US make up 75% of total survey respondents. The top six industries, comprising 60% of participants, were manufacturing, finance, professional services, computer services, insurance, and education.

Survey participants

More than half of the 450 companies that responded to the survey were willing to be named in the survey report. These respondents included AIG, American Express, AT&T, Aviva, BHP, Daimler Chrysler, Dow Chemical, Dupont, Fujitsu, Intel, Kraft Foods, Kimberly Clark, Merck, Molex, Motorola, Nike, Novartis, Levis Strauss, L'Oreal, Minter Ellison, Owens Corning, PepsiCo, Schering-Plough, Siemens, Tyco, and Zuellig.

In advising employers about preparedness for a potential pandemic, Mercer and its MMC affiliates, Marsh and Kroll, are able to offer their combined experience on business continuity planning forged through lessons learned from global crises over recent years.
 

PCViking

Lutefisk Survivor
Indonesia

23rd bird flu death in Indonesia

Friday March 31, 2006 14:30 - (SA)

JAKARTA - Indonesia's 23rd bird flu fatality has been confirmed by tests carried out by the World Health Organisation (WHO), while local tests showed another patient is infected, a health official said.

"We have just received the results and they are positive," the health ministry's I Nyoman Kandun said, referring to tests of samples from the 23rd victim, a one-year-girl from the capital Jakarta.

The girl died just over a week ago at Indonesia's main hospital for bird flu patients, Sulianti Saroso, after coming into contact with sick chickens near her house.

"We also received information today that an adult patient in West Sumatra has tested positive," Kandun said, adding that the patient was a 23-year-old man.

"He's still alive and being treated in Padang," the capital of West Sumatra province, he added. The official did not know his condition.

Local tests for the deadly H5N1 virus, which are usually accurate, are routinely sent to a WHO-affiliated laboratory in Hong Kong for confirmation.

Most cases in Indonesia have been in the capital and its surroundings, where many people live in close proximity to poultry despite the urban environment, but infected birds have been found in 26 of Indonesia's 33 provinces.

Experts fear that bird flu, which has killed more than 100 people since 2003, mostly in Asia, may mutate into a form that can pass easily between humans, sparking a deadly pandemic.

http://www.sundaytimes.co.za/PrintM...aytimesNEW/basket7st/basket7st1143808229.aspx

:vik:
 

PCViking

Lutefisk Survivor
Jordan

Friday 31 March 2006

First human case of H5N1 bird flu in Jordan

AMMAN (AFX) - An Egyptian worker has been detected in Jordan as suffering
from the deadly H5N1 strain of bird flu,
the first reported human case of the
virus in the country, a health ministry source said Friday.

"The first human case of bird flu has been detected in an Egyptian worker
who arrived in Jordan on the 27th (of March).
He is hospitalised and more than
likely caught the virus in Egypt," the source said.

The report came a week after Jordan announced it found its first case of
H5N1 in three dead turkeys on a farm in the north of the country.


http://freeserve.advfn.com/news_First-human-case-of-H5N1-bird-flu-in-Jordan_14852735.html

:vik:
 

JPD

Inactive
‘Every man for himself’ in Europe’s bird flu simulation​

http://news.ft.com/cms/s/62e60ba6-c0e0-11da-9419-0000779e2340.html

By Andrew Jack in London
Published: March 31 2006 19:22 | Last updated: March 31 2006 19:22


Plans by Switzerland to seal itself off in the event of a flu pandemic triggered “serious concern” by other countries during Common Ground, a recent simulation exercise, because of its strategic location as home to many drug and vaccine manufacturers.

This was just one of the many differences to emerge between European nations over border closures and emergency health measures in a training exercise whose results were published on Friday.

Similar concerns were raised about France, another important drug production centre, which also said it was considering border closures. However, French officials stressed they would exempt pharmaceutical workers and materials from travel bans.

Although judged “fit for purpose”, national plans paid less attention to international co-operation, incl-uding how to care for expatriates, restrict emigration and curb travel.

Several countries had not considered the possibility of school closures, or disruptions to public order, electricity supply and businesses.

The evaluation of the exercise, commissioned by the European Commission from the UK’s Health Protection Agency, called for greater understanding by member states of the laws governing travel restrictions across Europe.

Participants, who came from all EU member countries and neighbouring states, showed reluctance to share antiviral drug stocks with other countries.

The report said there was a need for greater transparency on the location of antiviral stockpiles, and more clarity for manufacturers on how the stocks they hold should be distributed.

The drug companies for their part called for greater guidance on legal liability, and an indication of which authority would decide when they should switch from the production of seasonal flu vaccines to those that would protect people from a pandemic strain. This was most likely to take place if bird flu were to mutate into a form transmissible between humans, which has yet to happen.

In the exercise, the European Commission’s Early Warning and Response System, designed to notify officials of human infections, became overloaded. The report called for back-up communications facilities and greater co-ordination between officials and the media.
 

JPD

Inactive
Governor Kulongoski's Plan Tells Oregonians How To Prepare For Outbreaks Of Pandemic Flu​

http://www.roguerivernews.com/articles/index.cfm?artOID=329527&cp=11031

By office of Governor Kulongoski

Portland, Oregon - Governor Ted Kulongoski recently released an updated Pandemic Influenza Plan for Oregon, including an educational website about the pandemic flu and preparation guidance for Oregonians and their families, and urged all Oregonians to take steps to soften the impact of a flu pandemic on themselves and their families.

At the first-ever Pandemic Influenza Summit, the Governor also called for clear outlines of the roles that federal, state and local public health agencies must play if an outbreak occurs.

"My goal is to ensure that every Oregon citizen, every business, every non-profit organization and every school is ready for a pandemic outbreak," the Governor said. "It is not enough to have good plans in place, because plans do not respond¿people respond."

Oregon's Plan covers scenarios that would likely surround the outbreak of a pandemic, and clearly explains the state's role in communication, surveillance, laboratory testing, vaccine and antivirals, travel advisories, community control measures and workforce support. As part of the Plan, the state provides technical support to local public health officials as they create their own disease-preparedness plans, which ultimately will be integrated into the state plan.

Joined by US Health and Human Services Secretary Michael Leavitt, Governor Kulongoski outlined the steps that Oregon is taking to prepare for the outbreak of an influenza pandemic. In addition to the newly updated Pandemic Influenza Plan, the state regularly conducts field tests to prepare for a disaster.

Last November, Oregon participated in a Strategic National Stockpile exercise to test the ability of state and local officials to work together to move vaccines and medications quickly to communities. Oregon has also developed a Secure Health Alert Network website to expedite communications between hospitals and public health entities in emergency situations.

The state has developed a "Hospital Capacity Website" to track the availability of emergency room beds in 60 hospitals throughout Oregon, together with medical supply capacities. The state is also developing a Volunteer Healthcare Registry to allow licensed healthcare workers to register in advance to help provide medical care during a public health emergency.

The Governor stressed that everyone has a role to play in protecting the health and safety of our families, employees and coworkers.

"Today's preparations can and will determine tomorrow's outcomes," the Governor said. "It is not in our interest to alarm anyone, but we do want people to know what to do in case there is an outbreak of the flu. This summit is an opportunity for us to exchange information, update plans and make the public aware of the threats."

Information on how to prepare for an influenza outbreak can be found on the Governor's website at http://governor.oregon.gov

Oregon News Online offers individual news websites for 350 cities and towns throughout Oregon.
Do you have a story you'd like to publish about your community? You can publish it using our Citizen Journalism feature.
There is no cost for using our news sites. Registering as a citizen journalist is free. It's easy to publish your stories on our news-sites.
Classified ads are free and are simultaneously published in all 350 news websites when you place an ad in any one of our sites.

The following link provides a list of all 350 news websites, including forums, event listings and Citizen Journalism sections:

http://www.medfordnews.com/articles/index.cfm?artOID=300803&cp=10995
 

JPD

Inactive
H5N1 Avian Flu Virus Vaccine Induces Immune Responses
In Healthy Adults

http://www.medicalnewstoday.com/medicalnews.php?newsid=40665

Main Category: Bird Flu/Avian Flu News
Article Date: 31 Mar 2006 - 22:00pm (UK)

Results from a clinical trial demonstrate that high doses of an experimental H5N1 avian influenza vaccine can induce immune responses in healthy adults. Approximately half of those volunteers who received an initial and a booster dose of the highest dosage of the vaccine tested in the trial developed levels of infection-fighting antibodies that current tests predict would neutralize the virus. The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, funded the study, published in the current issue of The New England Journal of Medicine. Preliminary results from this trial were first disclosed late last summer.

"These findings represent an important step forward in the nation's efforts to prepare for the possible emergence of a human pandemic of H5N1 avian influenza," notes NIH Director Elias A. Zerhouni, M.D.

"We are working hard to address the many challenges that remain with regard to the development of an H5N1 vaccine," adds NIAID Director Anthony S. Fauci, M.D. "For example, potentially protective immune responses were seen most frequently at the highest dose of this vaccine. We are investigating other options that may allow us to reduce the dosage--for example, adding an immune booster, or adjuvant, to the vaccine--so we can achieve a more practical immunization strategy." In addition, the U.S. Department of Health and Human Services is pursuing other approaches to an H5N1 vaccine, including vaccines made in cell cultures rather than grown in eggs.

H5N1 avian influenza viruses are of enormous concern to public health officials worldwide. The potential for a human avian flu pandemic looms large, say experts, as daily reports indicate an increasing spread of infection in bird populations in Southeast Asia, Europe, the Middle East and Africa. According to the World Health Organization, as of March 24, 2006, 186 people had been infected with avian flu viruses, and more than half of them had died.

Generally, flu viruses are easily transmitted from person to person, but so far, the H5N1 avian influenza viruses have not demonstrated this characteristic. In the worst-case scenario, if an avian flu virus became easily transmissible from person to person, it could trigger an influenza pandemic because humans have no pre-existing immunity to these viruses.

The trial, conducted between March and July 2005, was carried out at three NIAID-supported Vaccine and Treatment Evaluation Units located at the University of Rochester Medical Center in Rochester, NY; the University of Maryland School of Medicine Center for Vaccine Development in Baltimore; and the Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Medical Center. John Treanor, M.D., of the University of Rochester, led the group.

The study was conducted in two stages. In the first stage, the research team enrolled 118 healthy adults ages 18 to 64 years old. Each participant was assigned at random to one of five groups. Volunteers in each group received an initial dose of vaccine (7.5 micrograms [mcg], 15 mcg, 45 mcg or 90 mcg) or saline placebo into the upper arm muscle; about one month later, they received a booster shot of the same vaccine dosage or the placebo. The research team collected blood samples before each vaccination and one month after the second vaccination.

Before the study could be expanded, an independent Data and Safety Monitoring Board assessed the vaccine's safety by reviewing data collected through day 7 after the second vaccination; no safety concerns were found. The investigators then began stage two of the study, eventually enrolling an additional 333 healthy adult volunteers into the trial according to the same protocol design as in stage one.

The NEJM article describes an analysis of data on the safety and immune responses to the vaccine. In general, the higher the dosage of vaccine, the greater the antibody response produced. Of the 99 people evaluated in the 90-mcg, high-dose group, 54 percent achieved a neutralizing antibody response to the vaccine at serum dilutions of 1:40 or greater, whereas only 22 percent of the 100 people evaluated who received the 15-mcg dose developed a similar response to the vaccine.

Generally, all dosages of the vaccine appeared to be well tolerated:

* Almost all reported side effects were mild
* The second dose of vaccine did not cause more local or systemic symptoms than the first
* Systemic complaints of fever, malaise, muscle aches, headaches and nausea occurred with the same frequency in all dosage groups as in the placebo group
* Lab tests did not reveal any clinically significant abnormalities

The vaccine, made from an inactivated H5N1 virus isolated in Southeast Asia in 2004, was manufactured by sanofi pasteur, Swiftwater, PA, under contract to NIAID. Because there are no manufacturers licensed in the United States to use adjuvants in inactivated influenza vaccines, NIAID's first step was to test an H5N1 influenza vaccine made in a way that mimics the process used to make conventional flu vaccines. The clinical data collected in this study are now available to support the potential use of this vaccine should it be needed for an emerging pandemic.

###

NIAID is a component of the National Institutes of Health. NIAID supports basic and applied research to prevent, diagnose and treat infectious diseases such as HIV/AIDS and other sexually transmitted infections, influenza, tuberculosis, malaria and illness from potential agents of bioterrorism. NIAID also supports research on transplantation and immune-related illnesses, including autoimmune disorders, asthma and allergies.

The National Institutes of Health (NIH)--The Nation's Medical Research Agency--includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

Reference: J Treanor et al. Evaluation of an inactivated subunit H5N1 influenza virus vaccine in humans. The New England Journal of Medicine 354 (13):1343-51 (2006).

News releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov/

Contact: NIAID News Office
niaidnews@niaid.nih.gov
NIH/National Institute of Allergy and Infectious Diseases
 

JPD

Inactive
Expecting enough bird flu vaccine for everyone is a big ask

http://www.news-medical.net/?id=16983

Published: Friday, 31-Mar-2006


According to researchers an experimental vaccine produced to offer protection against the H5N1 strain of bird flu presently causing havoc across the world, only appears to work at the very highest doses.

The researchers say this means it will be much harder than first thought to protect the population against a pandemic.

The vaccine which was produced by Sanofi-Aventis is based on an H5N1 virus that killed a Vietnamese man in 2004 and it appears only a satisfactory immune response was seen in volunteers at two doses of 90 micrograms each, 12 times more than is needed for the annual seasonal flu shot.

The H5N1 flu virus has the capacity to cause a severe worldwide epidemic, with high attack rates, large numbers of deaths and hospitalizations, and wide disruption; effective vaccines against such viruses in humans are in urgent need.

Dr. John Treanor of the University of Rochester in New York and his team of colleagues, tested Sanofi-Pasteur's experimental H5N1 vaccine and found that the 90-microgram dose was the only one which produced antibody responses.

The study involved 451 healthy adults 18 to 64 years of age who were randomly assigned to receive two intramuscular doses of an influenza A (H5N1) vaccine of 90, 45, 15, or 7.5 µg of hemagglutinin antigen or placebo.

The subjects groups were then monitored for 56 days; serum samples taken before each vaccination and again 28 days after the second vaccination and were tested for H5 antibody.

The most common side-effect for all doses of vaccine was some slight pain at the injection site.

These results however indicate that there is in fact only enough H5N1 vaccine available in the U.S. to protect about 4 million Americans in a pandemic.

This would probably be used for key health-care workers and people working to make the vaccine.

The rest of the population would be relying on public-health measures such as closing businesses, schools and using protective equipment such as masks and gloves until an effective and sufficient amount of vaccine was produced.

The researchers say trials are now underway in elderly persons, persons with impaired immunity, or children, who may have a different response.

The H5N1 avian influenza virus has swept out of east Asia across to Europe and down into Africa, with frightening speed in recent months, spread in the main by wild birds.

Experts believe within a year or two it will become entrenched in wild birds across the globe.

It remains a predominantly bird disease and is difficult for humans to catch, but has nonetheless infected 186 people in eight countries and killed 105, according to the World Health Organisation.

Experts fear the virus could evolve into a form passed easily from human to human, causing a pandemic that could kill tens of millions.

Influenza viruses mutate quickly and it is nigh impossible to prepare a vaccine in advance that would precisely match a pandemic strain.

Supplies of flu vaccines are limited because of low demand, despite the fact that seasonal influenza kills more than 250,000 people every year globally.

Various organisations and drug companies are currently working on developing H5N1 vaccines, and across the globe 900 million doses could be produced at a push.

The United States alone would need vaccine to protect 300 million people, and to date 83 million doses is the most companies have ever made for the U.S. market.

More than 30 trials are underway, many of which look at ways to extend the vaccine by lowering the dose and adding other drugs to boost the immune response and lower the actual vaccine dose needed.

Some are also looking at faster and more modern production methods.

Treanor believes with two 90-microgram doses needed to produce a satisfying immune response, current manufacturing capacity falls far short.

The common annual flu vaccine mixes the three most common circulating strains of flu at 15 micrograms each while a pandemic vaccine would probably only use one strain. As a rule people only need a single dose of seasonal flu vaccine.

The report is published in the New England journal of Medicine.
 

Fuzzychick

Membership Revoked
JPD said:
UK...

'Mass grave' a possibility for victims if flu strikes'

http://iccroydon.icnetwork.co.uk/ne...ty-for-victims-if-flu-strikes--name_page.html

Mar 31 2006

VICTIMS of a flu pandemic in Croydon could be buried in a mass grave if the illness hits council workers.

A report into how the town would deal with a flu pandemic on the scale of the one that struck after the First World War has put the number of potential fatalities at 8,000 - with a quarter of the town's 330,000 population becoming infected.

A report drawn up by the council says the number of people dying would increase from 45 to more than 400 a week. At peaks this would mean the crematorium running 24 hours a day to cope and the council employing eight teams of gravediggers.

If the contingency fails, either through excessive staff sickness or through the failure of power supplies, "then the plan falls back on the use of a mass grave," the report says.

It adds: "This will only be used as a last resort as it poses many moral and psychological challenges."

Cllr Paul Smith, cabinet member for public protection and crime reduction, said: "This plan is not intended to scare anyone, quite the reverse. It is about saying we recognise the risk that exists and we are working with other London boroughs to make sure that whatever happens we are there to meet it."

The plan looks at a general flu pandemic but it leaves the council prepared to deal with an out-break if bird flu hit humans.


Go figure.:rolleyes:
 

Fuzzychick

Membership Revoked
"This would probably be used for key health-care workers and people working to make the vaccine.

The rest of the population would be relying on public-health measures such as closing businesses, schools and using protective equipment such as masks and gloves until an effective and sufficient amount of vaccine was produced"

Have to say I won't be standing in that line, neither will a number of individuals I know in the healthcare profession, I'm talking even docs, sorry, it hits the chips will fall where they're supposed to, I'm as ready as I'm gonna be with preventive measures, I'm not relying on the medical community, just myself.
 

pixmo

Bucktoothed feline member
<table width="100%" border="1" cellspacing="0" cellpadding="3" bordercolor="#000000" height="43"><tr><td bgcolor="D08153"><font face="Verdana, Arial, Helvetica, sans-serif" size="4"><b><font size="4" color="#FFFFFF">Clean the Blood, Cure Bird Flu?
</font></b></font></td></tr><tr><td bgcolor="#f5f5dc" height="2"><div align="left"><font face="Verdana, Arial, Helvetica, sans-serif" size="4"><b><font size="2">Fair use policy applies
http://www.wired.com/news/technology/medtech/0,70545-0.html?tw=wn_index_1</B>

California researchers say a blood-cleaning machine could save lives if bird flu becomes a pandemic. Fighting viruses by cleansing the blood might sound too good to be true, and many infectious disease experts say it is.

The device, called the Hemopurifier, performs a type of dialysis. According to James Joyce, founder and CEO of Aethlon Medical in San Diego, it can also remove smallpox and the Ebola and Marburg viruses.

The Hemopurifier works against so many different viruses, according to Joyce, that the device could one day serve as a "portable immune system."

Joyce's lofty claims make some infectious-disease specialists bristle. For one thing, dialysis carries a serious risk of infection, something Joyce himself admits.

"But if there is no alternative but death," said Joyce, "I'm betting that patients and their doctors will want this as an option."

Altheon scientists are seeking grants from the federal government's BioShield program to fund studies to prove their technology works. They're hoping for promising results from animal studies and a small trial on five human volunteers in India. So far, they have seen promising results only in studies performed with cells in a dish.

Even if it does work, applying the dialysis to millions of patients is logistically impractical, said Dr. Annie De Groot, director of the TB/HIV Research Laboratory at Brown University.

It is "easier to mass-produce vaccines than mass-dialyze people," De Groot said. "I wouldn't spend a lot of time on this approach."

But Joyce believes the Hemopurifier could be a better approach than vaccines, which can take months to develop because the virus continues to mutate. Plus, vaccines will only help those who have not yet contracted the disease.

Antiviral drugs such as Tamiflu are expected to be in high demand in a pandemic. Meanwhile, Tamiflu-resistant strains of avian influenza A (H5N1) are already emerging.

The Hemopurifier could reduce the amount of medication a flu patient needs, which would make the United States' antiviral drug stockpile last longer, Joyce said.

The technology consists of a traditional dialysis machine rigged with a cartridge invented by Aethlon scientists. As blood flows through the device, Joyce said, the Hemopurifier filters out viruses, allowing the patient's embattled immune system to become strong enough to fight off the disease.

The cartridge contains fibers with pores large enough for viruses and toxins to pass through. The viruses bind to proteins arranged outside the fibers. The cleansed blood then returns to the bloodstream.

Traditionally, cleansing the bloodstream of toxins is a process known as hemofiltration. The process has been used to treat sepsis, and even Anthrax and Marburg infections, which is why Joyce believes the Hemopurifier will work.

There is evidence to suggest that H5N1 is more invasive than other flu strains, and that it spends more time in the blood, a stage of infection called viremia, said Dr. Walter A. Orenstein, former director of the National Immunization Program at the Centers for Disease Control and Prevention and now a professor at Emory University.

In that viremic stage, something like the Hemopurifier could help reduce the patient's viral load, Orenstein said. But the treatment still may not save the patient, he said, because "the importance (of viremia in H5N1 infections) is unclear."

Indeed, Orenstein has serious doubts about a device that targets the flu in the bloodstream.

"You get the flu by inhaling it into your lungs," said Orenstein. "And most of the human deaths from H5N1 have been from pneumonia."

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Fuzzychick

Membership Revoked
Good post Pixmo, but you've gotta look at exposure time and when it becomes apparent. The problem that arises is when the person has already become symptomatic, by then there is massive organ involvement, the cytokine storms have already emerged. The other problem is that these machines probably will be in high demand, the unfortunate thing is that the vast majority will have already become emergent.
 

BREWER

Veteran Member
BREWER

Excellent posts. Lots of good articles and Great commentary. A bump for the evening shift. Thanks one and all.:chg:
 

feckful

Inactive
Brooks said:
You're damn right it requires blood-testing (or almost any other means) to confirm this crap. This "survey" has been soundly trashed and anyone who continues to rely on it is utterly clueless. It was based on folks' recollections of whether they coughed a bit more during a certain period and focused on those folks who won't want their flocks touched because someone thinks they maybe had bird flu. More recent, and far more valid, research has shown that h5n1 is a lower respiratory disease, and very lethal.

Folks, there is no large group of mild or asymptomatic cases. Further, in a pandemic context, the current h5n1 mortality wouldn't be 50%, it would be much closer to 100%. The patients that survived on the whole required very intensive and specialized care, the type of care and equipment that will quickly be overwhelmed if a large outbreak occurs.

The only good news so far is that, for the time being, h5n1 (being lower resipratory) is not very contagious. If it makes that transition and retains any lower respiratory component, we have a LONG ways to get from 50-100% to the mere 2.5% mortality of 1918, and then a long ways to the level of season flu.

Brooks, your comments are informed and accurate. The potential from bird flu H2H is so horrifying it's initially overwhelming to most people. moocollins' Mark Tier article URL leads to an Agora Financial page. They make their living selling investment advice. The conservative business-as-usual paradigm they live in does not allow for neutral consideration of anything that might disrupt normal market functions.
 
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