Bird flu could migrate to U.S.
http://www.baltimoresun.com/news/health/bal-te.avian05mar05,0,98899.story?coll=bal-health-headlines
Scientists identify Alaska as possible gateway for virus to enter Americas; focus put on wildfowl
By Frank D. Roylance
Sun reporter
Originally published March 5, 2006
As spring approaches in the Northern Hemisphere and millions of birds begin their ancient long-distance migrations, scientific evidence is mounting that the deadly Asian strain of H5N1 "bird flu" virus is flying with them.
If so, the virus may soon wing its way into Alaska - where biologists are establishing an unprecedented surveillance network as part of an aggressive, $29 million early warning campaign with a new focus on birds in the wild. Until now, scientists' greatest focus has been on domestic flocks.
From Alaska, scientists fear, the virus will spread into all the Americas and ultimately become a global presence - raising the odds it will mutate and touch off a new human flu pandemic.
"I think it is more likely than not that we are going to see [H5N1] bird flu in the Western Hemisphere," said Dr. William Schaffner, chairman of the department of preventative medicine at Vanderbilt University in Nashville, Tenn.
"Whether it takes place during this migratory season or the next is uncertain," he said. But "I wouldn't be at all surprised if we get some introduction of the virus during this ... season."
Scientists already suspect wild swans of carrying the H5N1 virus last month onto an island in northern Germany, where more than 100 of the graceful birds were found dead.
The virus later killed a house cat on the same island, and Dutch scientists have evidence that cats can spread the virus to one another in the laboratory. Meanwhile, Thai scientists have found that dogs and cats there could also be carrying the bug.
All of these findings raise new questions about whether a virus hitherto spread by wild birds can now infect and spread among the mammals people live with.
"Probably not," said Vanderbilt's Schaffner. "In the real world, unlike the research lab, we see no mammalian die-offs, and believe me, they would have been noticed.
"But this is something we have to keep watching, both in animal populations and in people," he said.
Confined for years to poultry flocks in Southeast Asia, the highly pathogenic strain of the H5N1 avian flu virus has been moving west since May.
Just since Feb. 1, according to the World Health Organization, it has turned up for the first time in wild birds and poultry in India, Iran, Egypt, Niger, Nigeria, Azerbaijan, Bulgaria, Slovakia, Hungary, Greece, Slovenia, Bosnia and Herzegovina, Serbia and Montenegro, Italy, Austria, Germany, France and Switzerland.
It's now present in at least 35 countries, and exports of birds or poultry products from those nations have been banned.
Although human commerce and travel can explain some of the spread of the virus, its velocity in recent months has scientists increasingly convinced that wild birds, and perhaps bird migration, are also playing a significant role.
"I think the evidence is now quite strong indicating that migratory birds are involved in serving as at least one carrier of the H5N1 subtype," said Dirk V. Derksen, supervisory wildlife biologist at the U.S. Geological Survey's Alaska Science Center, in Anchorage.
Avian influenza is not uncommon in waterfowl. There are many strains, and they are commonly passed around by the birds through their respiratory secretions and feces.
"What is uncommon is for migratory birds, particularly waterfowl, to be affected by it," said Paul G. Slota of the National Wildlife Health Center, in Madison, Wis. "In this case, there are instances where wild birds are dying from the H5N1 Asian strain."
It's a strain that veterinary health officials call highly pathogenic to poultry, or "high-path." More common "low-path" strains produce little or no illness in poultry flocks, and low mortality rates.
The big worry among global health authorities is that this "high-path" strain of H5N1 will infect so many poultry farms that it will eventually mutate into a form that can pass from person to person.
Humans generally have had no previous exposure to this bird virus, and health officials fear that its spread would trigger a global pandemic, potentially killing tens of millions of people.
So far, the virus doesn't have that capacity, and its human toll remains low.
Since 2003, at least 174 people - in Southeast Asia, Turkey and Iraq - have been reported with H5N1 infections. Nearly all were ascribed to direct contact with infected poultry or contaminated surfaces, according to the WHO. Ninety-four of those have died - a fatality rate of 54 percent.
No one has reported a human H5N1 infection from contact with wild or migratory birds. But wild birds do appear to be spreading it, and scientists think the most likely route to the Americas will be through Alaska.
The 49th state is an avian mixing bowl. Migrants winging along flyways from Asia, the central Pacific and western North America converge there to forage and breed in the northern summers.
And that's where the federal government is focusing its new $29 million Interagency Strategic Plan for early detection of high-path Asian H5N1.
From now through the fall, biologists and field specialists from the U.S. Departments of Agriculture and the Interior, as well as state agencies, will fan out across Alaska and U.S. possessions in the Pacific.
They will trap and draw viral samples from more than 75,000 live birds and collect 50,000 samples of water and bird feces.
Their goal is to learn more about which avian pathogens are being passed around by which migrating birds - and to sound the alarm when the high-path H5N1 virus arrives in the Western Hemisphere.
But not everyone is ready to lay blame for the spread of the virus solely on migrating birds.
One of them is Hon Ip, director of the Diagnostic Virology Lab at the National Wildlife Health Center, one of several federal labs that will test the samples from Alaska and the Pacific.
Wild birds may be a factor in the spread of the virus across Europe this winter, he said, but maybe not by migrations. Instead, he suggests that severe cold may simply have moved nonmigratory species to new locations. Will their presence now ignite new outbreaks among local birds and poultry flocks? Or have they just flown a short distance and died, with no further consequences?
"It could go either way," Ip said. "All Europe is playing in this giant experiment."
Ip also questions whether an Asian strain of bird flu is capable of becoming a long-term problem in the Americas. "Historically there's been a clear [genetic] separation between North American avian influenza viruses and those in Europe and Asia," he said. To a geneticist, "it's almost like a fingerprint. You can tell them apart."
If they mixed regularly, they would be indistinguishable, Ip argues.
The government's surveillance work in Alaska may resolve the issue. Nearly 30 species have been targeted - mostly waterfowl and shore birds, from the Aleutian cackling goose to Steller's eider and the sharp-tailed sandpiper.
"It's clearly the largest effort to capture and sample migratory birds I'm familiar with," Derksen said.
State and federal officials will also sample birds killed by indigenous hunters and sportsmen. Ip's lab will watch for the virus among the thousands of wild birds and other animals whose carcasses are sent there routinely for testing each year.
But the Alaska Science Center teams will focus on live, wild migratory birds, Derksen said.
Waterfowl such as emperor geese and Pacific black brant ducks will be herded into "drive nets" erected in estuaries and on lake shores where the birds molt. The molting renders the birds flightless for a time, and sampling teams, in boats or on foot, will simply herd them into the nets.
After they measure and band each bird, team members will pass a swab into its cloaca - the single opening through which a bird's urinary and intestinal tracts empty. Then they'll release each bird, pack the swabs in ice and send them to Ip's lab.
For perching birds, the teams will use barely visible "mist nets," designed to snare them as they fly through woods or across open tundra. Scientists say they aren't injured and fly off as soon as they're released.
For marine waterfowl, mist nets will go up in the open ocean, strung between anchored buoys and surrounded by decoys. On land, spring-loaded "bow traps" will capture birds where they're nesting. "The birds released typically return right to the nest," Derksen said.
Of particular interest is the Steller's eider. Listed as threatened in Alaska, it breeds in Alaska's Yukon Delta, near Barrow on the northern coast of Alaska, and in northeastern Russia. All the populations migrate south across the Chukchi Sea and the Bering Sea to winter on the Alaskan Peninsula.
"So the opportunities for mixing of birds from Russia, where the H5N1 virus has been isolated, and birds from Alaska are considerable," Derksen said. "Other birds use these same habitats in this estuary at the same time."
What public health officials fear most is that wild birds will eventually spread the virus to huge poultry flocks and rural backyard coops. If that happens, poultry deaths from infection, or from culling to stop the spread of the disease, will exact a heavy toll on the food industry.
A spreading H5N1 epidemic among poultry would also bring the virus into contact with more people, increasing the risk that it would swap genes with an ordinary human flu virus and launch a deadly pandemic.
The discovery that a domestic cat in Germany was killed by the H5N1 virus has renewed worry that the avian virus may already be acquiring the ability to infect and spread among the mammals people live with.
Tigers and leopards at the Bangkok Zoo died after they were fed infected chickens during a 2003-2004 bird flu outbreak.
A recent study by Dutch scientists Thijs Kuiken and Albert Osterhaus, of Erasmus University in Rotterdam, found that lab cats infected with the H5N1 virus excreted the virus in their urine, feces and saliva before they died.
That led to fatal infections among the healthy cats they lived with - proof that the virus can cause cat-to-cat transmission, according to a paper published in January's American Journal of Pathology.
More recently, a news story in the journal Nature reported that Thai scientists tested 740 village dogs and cats and found that 25 percent of the dogs and 7 percent of the cats had antibodies to the H5N1 virus - evidence they had at least been exposed.
But Schaffner isn't worried about a threat to humans from their pets. "We can take it as a general theme that ... this bird flu virus can get into mammals. But it isn't really transmitted," he said.
The cat-to-cat transmission in the Dutch experiments is "instructive," he said. But virologists know that lab findings don't always translate to the real world.
"There is one sort of animal we ought to keep our eye on," he said. It's pigs, whose cells can harbor both avian and human flu viruses, and where the feared viral recombination might well occur.
Even with all the H5N1 outbreaks in Asia, where poultry and pigs frequently live in proximity, Schaffner said, "we have seen no pig die-off."
But "many of us are walking around with fingers crossed that these recombinant events have not taken place already."
' written all over 'em! Great catch NF
Um like there are tens, if not hundreds of thousands of dead Chinese already in my personal opinion. And yes, TPTB have been lying for months about it. 