1/18 H5N1 | "Bird Flu: Politics and Propaganda"

PCViking

Lutefisk Survivor
BBQ in Van to allay bird flu fears
Rough Cut
02:54​

Jan. 17 - The largest poultry producer in Turkey, where four children have died of bird flu, hold a chicken barbeque party to emphasis that cooked chicken is safe to eat.

Turkey's Prime Minister earlier told consumers it was safe to eat chicken despite an outbreak of bird flu in the country which has killed four and led to the culling of around a million birds in the region.

Resat Bayat, of Bayat Chicken and Egg Production in Van, said they held the barbecue and ate the chicken meat themselves to prove to the public that chickens and eggs produced in the industrial factory are healthy.

Poultry sales have plunged since the latest outbreak of avian flu in Turkey was reported in late December. Experts say chicken and eggs pose no health threat if properly cooked.

Slaughtering and defeathering a diseased bird pose the greatest risk of the virus passing to people. The four dead children and the 17 other people treated for the virus all had close contact with sick birds.

The financial impact of the disease has so far been mainly confined to the poultry sector. However, the Milliyet newspaper said on Tuesday it could eventually cost the country some $3 billion, or one percent of gross national product (GNP).

The government fears that failure to stamp out the disease quickly could harm the $20 billion tourism industry.

http://today.reuters.com/tv/videoSt...ryId=9e79463a96f26a09344dae969bb567a3c0d9f0e2

:vik:
 

PCViking

Lutefisk Survivor
OK, so are the Turkish officials, trying to prove that it's not the chickens that are getting people sick with H5N1?

Does that mean that it's people getting each other sick with H5N1? Hmmmm....

:vik:
 
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<center>:hmm:

PCVing, please let me know if you see something you might like as being a better title for this new H5N1 thread on any of the next news articles... Personally, that one on this first article is ...well, kind os *S*tty ifn' ya ask me..

I'lll change it out to what ever you decide (right now), unless some one is into BBQ - they might not think it interesting enough to click on LOL

Dutch
 
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<B><font size=+1 color=red><center>Suspected bird flu cases rising in West Java</font>

By Yuli Tri Suwarni
The Jakarta Post
Publication Date : 2006-01-18
<A href="http://www.asianewsnet.net/level3_template1.php?l3sec=8&news_id=51301">www.asianewsnet.net</a></center>
A three-year-old boy who died Tuesday (Jan 17) is believed to be the second fatality from avian influenza in his family after an older sibling's death last week.</b>

The boy was pronounced dead at Hasan Sadikin Hospital in Bandung after his 13-year-old sister died in their hometown of Indramayu, West Java, last weekend. A preliminary Health Ministry investigation showed the children's family allowed poultry in their home.

Initial tests by the Health Ministry showed the teenager was positive for the deadly H5N1 strain of avian influenza which has already killed at least 80 people worldwide.

The ministry's laboratory, accredited by the World Health Organisation (WHO), has confirmed 12 deaths in Indonesia and five cases where patients have survived the illness, although final confirmation is needed from the WHO laboratory in Hong Kong.

Most of the dead victims hailed from Greater Jakarta.

The H5N1 virus is not known to pass between humans at present, but experts fear it could develop that ability and set off a global pandemic that may kill millions of people.

Siti, 53, another suspected avian influenza patient, died on Sunday (Jan 15) evening after being treated for eight hours at Hasan Sadikin hospital.

Avian influenza is also suspected in the condition of three other people hospitalized at the hospital, including the Indramayu siblings' 15-year-old sister. The other patients are a West Java health service officer and a resident of Bandung.

All of the patients were admitted to the hospital with similar symptoms -- breathing problems and high fever -- but two of them also had acute pneumonia.

The death of the toddler only a few days after his sister has raised concern among medical workers. Hadi Jusuf, head of the hospital's special infections team, said the boy's condition showed improvement Monday (Jan 16), with a drop in his temperature, but he experienced breathing problems Tuesday (Jan 17).

"We tried to give him oxygen and artificial respiration, as well as antibiotics and Tamiflu, but God decided otherwise," said Hadi, who was convinced the boy died of H5N1.

Health Ministry and WHO representatives have been sent to Indramayu to investigate the suspected cases in the one family.

The head of the disease evaluation and counselling section of the Health Ministry, Tato Suharto, said an initial investigation found 14 dead chickens near the family's home.

"Because of the fear of theft, the family put their chickens in their kitchen at night. Besides living together with the chickens, the family also lived close to other animals, including birds and ducks," he said.

Pigeons were also kept at the home.

Hadi also said most of the suspected avian flu patients being treated at the hospital were also believed to have had close contact with poultry.
 
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<B><font size=+1 color=brown><center>Another child found with lethal H5N1 bird flu strain</font>

Agencies in Ankara and Beijing
Wednesday January 18, 2006
The Guardian
<A href="http://www.guardian.co.uk/birdflu/story/0,14207,1688793,00.html">www.guardian.co.uk</a></center>
Preliminary tests indicate that another Turkish child is infected with the deadly H5N1 strain of bird flu, health officials said yesterday, raising the number of human cases in the country to 21.</b>

The health ministry said the child was from Dogubayazit, the home of all four of the other children who have died of H5N1. Experts meeting in Beijing said the world urgently needed to amass a war chest to fight bird flu and prepare for a pandemic strain.
 
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<B><center>Wed 18 Jan 2006

<font size=+1 color=green>World unites to battle killer bird flu</font>

MARGIE MASON
IN BEIJING
<A href="http://news.scotsman.com/index.cfm?id=83982006">news.scotsman.com</a></center>
THE European Union and the drug maker Roche each sharply increased their commitment to fighting bird flu yesterday. </b>

The EU pledged 100 million (£69 million) to combat the disease and the risk of a potential pandemic, as Turkey announced a fifth child had tested positive for the H5N1 virus, which has already killed four youngsters. The latest case brings Turkey's total number of confirmed H5N1 cases among humans to 21.

Meanwhile, the World Health Organisation (WHO) revealed that the Swiss company Roche had agreed to donate a further two million courses of the anti-viral Tamiflu to help poor countries battling the disease.

According to the World Bank, up to $1.5 billion will be needed over the next three years to tackle the bird flu threat in poor countries, and as a donors' conference opened in Beijing yesterday, there were hopes of topping that figure.

Markos Kyprianou, the EU's health commissioner, said that, on top of the bloc's new cash commitment, the 25 member states were likely to pledge about £70 million in total. The United States is expected to make one of the largest pledges today.

At least 79 people in Asia and Turkey have been killed by bird flu since 2003, and the World Bank has said about 45 per cent of the funding will be spent in Vietnam, Cambodia, Indonesia, Thailand and Laos - countries where the H5N1 virus is already endemic.

Most human cases have been traced to contact with infected birds, but experts fear the virus could develop the capacity to transmit easily between people, sparking a possible pandemic that could kill millions.

Dr Shigeru Omi, the WHO's regional director for the western Pacific region, said the recent outbreaks in Turkey showed the need for heightened monitoring of poultry, to stop the disease from infecting people. "Surveillance is crucial because, in my view, the outbreaks affecting transmission among chickens were there for some time without being noticed," he said.

Last year, Roche donated three million courses of Tamiflu, believed to be most effective in treating bird flu in humans, for a global stockpile that would be distributed wherever a pandemic flu strain emerged.

Dr Margaret Chan, the assistant director-general for communicable diseases at the WHO, said the new donation would be used to help poor countries treat cases of human bird flu as they developed, to try to reduce the number of deaths and slow the spread of infection.

The Beijing conference, sponsored by the World Bank, the European Commission and the Chinese government, follows a global bird flu co-ordination meeting in Geneva two months ago that involved 100 countries.
 
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<B><center>New Zealand

<font size=+1 color=blue>Bird flu mail drop to 1.4m households</font>

18 January 2006
<A href="http://www.stuff.co.nz/stuff/0,2106,3543967a11,00.html">www.stuff.co.nz</a></center>
The Ministry of Health intends to send out brochures, a covering letter and fact sheet to about 1.4 million households to prepare for a bird flu pandemic.

The brochures, in a national letterbox drop, will contain information on setting up emergency kits, hygiene and guides for those working from home or running a business, an Auckland newspaper reported today. </b>

It is believed the campaign would begin in March.

Bird flu has killed at least 79 people since 2003, according to the latest WHO tally which does not include some of the most recent cases reported in Turkey and Indonesia. Victims contract the virus through direct contact with infected birds.

While difficult for people to catch, nearly 150 people are known to have been infected by H5N1 in six countries, killing more than half its victims, a death rate that reinforced fears about the havoc the virus could wreak if a pandemic occurs.

The NZ Herald reported the mail drop campaign was designed to complement print, radio and television advertising, which would run at the same time.

Advertising started on National Radio this week.

AdvertisementAdvertisementThe ministry announced last year its intention to put out public service messages on bird flu.

The cost of the publicity campaign has not been finalised yet according to the report.

Acting director of public health Dr Ashley Bloomfield who would not confirm a mail drop said moves to raise awareness would include more paid advertising, updates to the website and 0800 number, and "possibly" a nationwide letterbox drop.
 
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<B><center>January 18, 2006

<font size=+1 color=purple>Cyprus takes measures to prevent outbreak of bird flu </font>

<A href="http://english.people.com.cn/200601/18/eng20060118_236326.html">english.people.com.cn</a></center>
The Cypriot government said Tuesday that all necessary measures are being taken to prevent an outbreak of bird flu on the island after four people died of the disease in neighboring Turkey. </b>

Cypriot Minister of Foreign Affairs George Iacovou said he met with UN chief's special representative in Cyprus and head of mission of the UN peacekeeping force on the island (UNFICYP) Michael Moller, who reassured that there was no bird flu case in northern Cyprus.

Meanwhile, Minister of Health Andreas Gavrielides told reporters that the government has measures in place to prevent an outbreak of bird flu and authorities would discuss further measures to tackle any case that may appear on the island.

Part of the measures is to seek additional supplies of anti- viral drugs from the European Union, he said.

Commenting on negative tests on a person allegedly suffering from the disease in northern Cyprus, he said that "so far, we have not forbidden or closed the crossing points" between the two sides of the island.

Meanwhile, Minister of Agriculture, Natural Resources and the Environment Timmy Efthymiou said the government was monitoring the situation in the north and assured that the Veterinary Services, in cooperation with the EU standing veterinary committee, would be taking all necessary measures, if and when necessary.

Cyprus has been divided into Greek Cypriot south and Turkish Cypriot north since 1974 when Turkey sent troops to take control of northern third following a coup seeking union with Greece.

The breakaway northern Cyprus, which has close relations with Turkey, has also taken some measures to curb a possible bird flu outbreak, which include a ban on poultry imports from Turkey and confining reared poultry in coops.

Source: Xinhua
 

PCViking

Lutefisk Survivor
The Flying Dutchman said:
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:hmm:

PCVing, please let me know if you see something you might like as being a better title for this new H5N1 thread on any of the next news articles... Personally, that one on this first article is ...well, kind os *S*tty ifn' ya ask me..

I'lll change it out to what ever you decide (right now), unless some one is into BBQ - they might not think it interesting enough to click on LOL

Dutch

Dutch, how 'bout "Bird Flu: Politics and Propaganda"

The article really blew me away that TPTB in Turkey, would hold a chicken BBQ to illustrate that the chickens are safe, while kids are dropping like flies... It's all about tourism and the poultry industry... Follow da money

What they don't realize is that in trying to say that the chickens are safe, they are saying that H5N1 transmission is human to human?

As for an H5N1 post, this article was too ironic to pass up.

:vik:
 
PCViking said:
Dutch, how 'bout "Bird Flu: Politics and Propaganda"

The article really blew me away that TPTB in Turkey, would hold a chicken BBQ to illustrate that the chickens are safe, while kids are dropping like flies... It's all about tourism and the poultry industry... Follow da money

What they don't realize is that in trying to say that the chickens are safe, they are saying that H5N1 transmission is human to human?

As for an H5N1 post, this article was too ironic to pass up.

:vik:

There ya be PCV...

And yup! The gov.org PTB are all the same, the world over. Keep the sheep in the dark (kinda like raising Mush Rooms) - only the sheeple get more B/S)

FWIW (IMHO and such) - H5N1 is moving H2H with-in family groups; and thought to have moved H2H in a couple instances in a non-family clustering...
 

John H

Inactive
Just a quick comment.

If you're cooking H5N1 infected chickens, you're going to be handling the raw chicken, disposing of the container it came in (including some blood and fluids), possibly having a cutting board and knife to cope with deep cleaning and having it sit in the garbage for a while, to be breathed in the next time you open the garbage can or bag.

I'll pass on chicken, once it's here, thanks.

:ld:

John H
 

Nuthatch

Inactive
I missed this if it was posted before: from www.news.scotsman.com


Wild duck shot in Scotland had bird flu
LOUISE GRAY

A DUCK shot in Scotland was suffering from a strain of bird flu, it emerged yesterday, amid growing fears of human cases of the virus in Turkey.

The mallard, shot in West Lothian in October, was tested in a UK-wide survey of hundreds of birds to check for the virus.

Out of 280 birds shot and tested, it was one of two to be infected with a strain of avian flu. However, the low-risk strain, known as H6N2, cannot spread to humans. A sheldrake was also found to be infected with a low-pathogen strain in England last year.

Scientists are on the alert for the virulent H5N1 strain spreading from Asia, where it has killed more than 70 people.

That strain has already come as far as Turkey, where it has infected 19 people and killed three children in confirmed cases.

Yesterday, there were fears a young girl had become Turkey's fourth victim, although initial tests had proved negative. In Germany, a man who had visited Turkey was admitted to a hospital in Cologne with symptoms similar to those associated with bird flu. However, he was later reported to be clear of the virus.

The Department for Environment, Food and Rural Affairs (DEFRA) stated it was highly unlikely the duck found in Scotland would have come from areas where H5N1 has been found.

A spokeswoman said: "It is extremely unlikely this duck would have come from anywhere other than Europe. This finding is not of particular concern." It is thought the bird would have come to Scotland via western or eastern Europe.

But the discovery underlines the difficulty of ensuring that the UK remains free of bird flu, despite the extensive movement and mixture of birds.

Governments across Europe are keeping an eye on the wild bird population in order to ensure bird flu does not spread to domestic fowl. Once in poultry farms, the virus tends to become more dangerous.

DEFRA's first study of wild British birds last year tested almost 1,500 carcases caught live and shot.

Ornithologists have warned that wild birds could bring the virulent H5N1 virus to Britain by migratory routes. But even if this is to happen, it is not likely to be until autumn this year, when birds begin returning from migratory grounds in the east. The coming spring migration from Africa is considered low-risk.

However, the Conservatives criticised the government yesterday for being "complacent" in not reviewing contingency plans for bird flu until after the spring migration had taken place.

James Paice, the shadow environment minister, said the review should be carried out immediately, considering the seriousness of the threat.

He said: "Any simulation exercise to test the UK's preparedness for an outbreak of bird flu must take place immediately - not after the spring migration when many experts believe we are most likely to be exposed to the disease. Given the implications of a national outbreak, it is imperative that the government's contingency plans are reviewed now, so that the current state of readiness can be assessed and improved before the threat increases.

"It seems complacent in the extreme to delay this exercise until April, by which time it might be too late."
 

Nuthatch

Inactive
from the BBC: 2 hours ago:

Iraq tests dead girl for bird flu

Iraq has ordered tests to confirm what may be the country's first case of bird flu, following the death of a girl in the northern city of Sulaymaniyah.
The teenage girl from a town near the border with Turkey and Iran died at a hospital in the city, 15 days after falling ill, officials said.

Tests are being carried out in Jordan to see whether the girl died from the lethal H5N1 strain of the virus.

An outbreak of bird flu has killed four people in Turkey, which borders Iraq.

Since 2003, the virus has killed around 80 people and thousands of poultry in south-east Asia and China.

All human deaths so far are believed to have been caused by contact with infected animals.

While experts warn that a mutant form of the virus that transmits between humans could lead to a pandemic, so far there is no evidence of this taking place.

Family 'well'

The girl suspected of having the disease was from the town of Raniya, in a border region of Kurdish northern Iraq, Kurdish regional health minister Mohammed Khashnow told Reuters news agency.

She died shortly after arriving at a hospital in the main city of Suleymaniyah.

Mr Khasnow told the agency the rest of the girl's family are in good health and do not work in the poulty business.

It is not yet clear when the results of the tests for bird flu will be known.
 

PCViking

Lutefisk Survivor
Bird Flu, an excuse for human chipping

STMicro to market chip to detect bird flu in humans
Wed Jan 18, 2006 4:38 PM GMT

By Caroline Jacobs and Astrid Wendlandt​

PARIS (Reuters) - STMicroelectronics is planning to market a disposable laboratory microchip that can confirm within about an hour a human case of bird flu at a limited cost, the European chip maker said on Wednesday.

The Franco-Italian group is developing a test that could be available to healthcare providers this autumn with Singapore-based medical diagnostics company Veredus Laboratories Pte Ltd.

"To be available in time for the next flu season, the single-test application will be a substantial breakthrough in enabling rapid identification of the infectious agent to limit the spread of the disease and speed patients' treatment," STMicro said in a statement.

The H5N1 avian flu virus has killed at least 79 people since 2003, according to the latest WHO tally which does not include some of the most recent cases reported in Turkey and Indonesia.

Victims contract the virus through direct contact with infected birds.

Veredus is developing an application, based on STMicro's technology, to identify if a patient is infected with the H5N1 strain or a subtype of influenza in a single test that could replace the several tests currently used to detect the illness.

The diagnostic is built on STMicroelectronics' "In-Check" platform, which is described as a complete laboratory on a chip.

The lab-on-chip uses a sample of blood or a swab from the throat or nose to detect the virus, which is read by a machine.

The companies, which declined to reveal price details, said they planned to target high-return niche areas such as airports and immigration points before moving into more mainstream markets, such as hospitals.

Veredus' Managing Director Chua Chee Min said most "dip-stick" tests were only 80 to 90 percent accurate while their latest product was 99 percent accurate.

"The ultimate goal is to make this available in clinics," Chua said.

Veredus launched last year a polymerase chain reaction (PCR) test kit which detects the H5N1 strain in both humans and poultry within about four hours. The product is already on the market, mainly in Europe, Asia and the Middle East.

The companies added that their new chip would be cost competitive so long as they can secure large orders.

The semiconductor group, which is battling fierce price competition in several of its markets, said this new product allowed it to further diversify its source of earnings.

Anton Hofmeister, group vice president and general manager of STMicro's Microfluidic division, said the group was looking to apply its chip technology to other illnesses and hoped to announce similar partnerships soon.

"We are looking at several other diseases such as malaria, pneumonia and meningitis," Hofmeister said.

STMicro shares were down 1.65 percent at 15.45 euros by 1627 GMT.

http://today.reuters.co.uk/news/new...416139_RTRIDST_0_OUKIN-UK-STMICRO-BIRDFLU.XML

:vik:
 
PCViking said:
STMicro to market chip to detect bird flu in humans
Wed Jan 18, 2006 4:38 PM GMT

By Caroline Jacobs and Astrid Wendlandt​

PARIS (Reuters) - STMicroelectronics is planning to market a disposable laboratory microchip that can confirm within about an hour a human case of bird flu at a limited cost, the European chip maker said on Wednesday.

PCVing;

On this one I fully agree with you. Chips can have more than one function.

Personally as I type this; I am thinking it'll be a cold day in *H*! Before they can sucker me with needing a chip - just so's they can tell if I have H5N1 (with out them being able to use GPS to come help me no matter where I may have gotten off to, when I contracted the bug.)

Noppers! Don't like the sound of this one at all.......
 

Fuzzychick

Membership Revoked
The Flying Dutchman said:
PCVing;

On this one I fully agree with you. Chips can have more than one function.

Personally as I type this; I am thinking it'll be a cold day in *H*! Before they can sucker me with needing a chip - just so's they can tell if I have H5N1 (with out them being able to use GPS to come help me no matter where I may have gotten off to, when I contracted the bug.)

Noppers! Don't like the sound of this one at all.......


I agree with ya! Sounds rather convienent don't ya think?:dvl1:
 

RAT

Inactive
Extended Transmission Chains of H5N1 in Mus Turkey

Recombinomics Commentary
January 18, 2006

A family in Mus sick after eating a sick rooster. One dead, two at the hospital

After the father Abdullah Alkan (40) cut the animal 17 days ago, mother and the daughter have plucked and cooked the chicken

2 year old Berfin Alkan got sick afterwards

Berfin Alkan (2) passed away 15 days ago (2 days after eating the chicken), the eldest daughter Nese Alkin got sick a week later and she was taken to Mus State Hospital

She has been sent to Diyarbakir Hospital 2 days ago with BF suspicion. Her swabs are sent to Ankara. She is in Diyarbakir Hospital for 5 days now

Following all those incidents the 4 year old Huseyin Alkan developed high fever last night and the family is taken by ambulance to Mus State Hospital

The above translation of a suspected familial cluster in Mus, suggests two chains of human-to-human transmission within the Alkan family.

The time gap between disease onset dates strongly suggests that the 2 year-old infected the oldest sister, who the infected the 4 year-old.

The size of other clusters is also consistent with human-to-human transmission within families, but onset dates have been absent from WHO updates, as has relationships of confirmed cases with other confirmed or suspect cases.

The increased efficiency of transmission of H5N1 to humans in Turkey has been marked by the large number of cases, clusters, and size of clusters.

The above cluster, with disease onset dates, provides a clear example of human-to-human-to-human transmission of H5N1 in Turkey.
 

RAT

Inactive
Supected H5N1 Fatality in Iraq

Recombinomics Commentary
January 18, 2006

Health officials in northern Iraq have sent samples to Jordan for testing for the bird flu virus H5N1 after a 14-year-old girl died in the Kurdish city of Sulaimaniya, officials said on Wednesday.

Tijan Abdel-Qader died on arrival at the main hospital on Tuesday after falling ill 15 days earlier in her home town of Raniya, in Kurdistan close to the Turkish and Iranian borders, Kurdish regional health minister Mohammed Khashnow said.

"The doctors in Sulaimaniya suspected this might be a case (of bird flu)," he told Reuters. "They have sent samples to Amman and we will know the results next week."

Raniya is close to Lake Dukan, which draws many migratory birds to the region and where Iraqi officials had been taking measures to try to prevent domestic fowl from being infected.

"The rest of the family is in good health," Khashnow added, saying the family was not in the poultry business.

The above comments suggest H5N1 has migrated across Turkey’s southern border and has cause a human fatality in Iraq. The lack of contact with poultry and the proximity to migratory birds signals a movement of H5N1 throughout the Middle East. The recent OIE report on H5N1 in Turkey identified H5 in wild birds and the confirmed or suspected wild bird and domestic poultry outbreaks blanketed Turkey. These data left little doubt that H5N1 had spread into neighboring countries.

However, none of the countries in the Middle East have filed OIE reports for H5N1 and if this case is positive, it would be the first reported human case outside of Turkey.

These data are of concern because they suggest that polymorphisms such as HA S227N and PB2 E627K have increased the transmission of H5N1 to humans. In Turkey there are many large clusters, demonstrating extensive human-to-human transmission and this case in Iraq suggests similar transmissions will soon be reported throught the Middle East.

More information on testing of this suspect case would be of use. Since symptoms began 15 days earlier, it is probably too early for antibody tests and too late from nose or throat swabs. However testing on lung samples would more likely identify an H5N1 infection.

In Turkey, all four fatal cases initially tested negative for H5N1, but were subsequently positive, especially when lung material was tested. Similar testing in Iraq would be useful.
 

JPD

Inactive
Alarms ring over bird flu mutations

http://www.nature.com/nature/journal/v439/n7074/full/439248a.html

Declan Butler

Turkish virus shows increased affinity for humans.

Scientists studying virus samples from the human outbreak of avian flu in Turkey have identified three mutations in the virus's sequence. They say that at least two of these look likely to make the virus better adapted to humans.

The Turkey outbreak is unusual, because of the large family clusters of cases; the fact that many of those infected have only mild symptoms; and the speed with which infections have arisen — twenty cases, including four deaths, in less than two weeks. So scientists are urgently trying to establish whether the virus is behaving differently in this outbreak from previous ones in Asia. In particular, international teams are investigating the possibility that the virus is moving between people.

"With such a large number of cases within such a short period of time, human-to-human transmission is something that we've had to consider," says Maria Cheng, a spokeswoman at World Health Organization (WHO) headquarters in Geneva.

As Nature went to press, samples from the first two teenagers in the country to die had been sequenced by a WHO collaborating centre at the National Institute of Medical Research (NIMR) in London.

The results so far are not comforting. The first mutation found, announced last week, involves a substitution in one sample of an amino acid at position 223 of the haemoagglutinin receptor protein. This protein allows the flu virus to bind to the receptors on the surface of its host's cells.

This mutation has been observed twice before — in a father and son in Hong Kong in 2003, and in one fatal case in Vietnam last year. It increases the virus's ability to bind to human receptors, and decreases its affinity for poultry receptors, making strains with this mutation better adapted to infecting humans.

The same sample also contained a mutation at position 153 of the haemoagglutinin protein, Nature has learned. Cheng says this information was not included in WHO statements, because "it is not clear what role this particular change plays".

Finally, both samples from the Turkish teenagers show a substitution of glutamic acid with lycine, at position 627 of the polymerase protein, which the virus uses to replicate its genetic material. This mutation has been seen in other flu sequences from Eurasian poultry over the past year. It was also present in the one person who died during an outbreak of H7N7 in the Netherlands in 2003, and in a few people in Vietnam and Thailand.

The recent outbreak of bird flu in Turkey has thrown up viruses with mutations that threaten humans.

The polymerase mutation is one of the ten genetic changes that gave rise to the 1918 pandemic flu virus. Like the 223-haemoagglutinin mutation, it signals adaptation to humans, says Alan Hay, director of a WHO influenza laboratory at the NIMR. "There is this glutamic acid–lysine flip," he explains. "Glutamic acid is associated with flu-virus replication in birds, and lycine is in primates."

The Turkey strains are the first in which the polymerase and receptor-binding mutations have been found together. They could make it easier for humans to catch the virus from poultry. But they might also favour human-to-human transmission. This is because the polymerase change helps the virus to survive in the cooler nasal regions of the respiratory tract, and the haemoagglutinin mutation encourages the virus to target receptors in the nose and throat, rather than lower down in the lungs. The virus is thought to be more likely to spread through droplets coughed from the nose and throat than from infections lower down.

Hay points out, however, that it is difficult to predict how the mutations will actually influence the virus's behaviour. He adds that just two changes are unlikely to create efficient human-to-human transmission on their own.

Establishing what effects these changes are having on the epidemiology of the current outbreak is a top priority for research teams working in Turkey. "We must learn more about the mild cases and be absolutely sure of whether these viruses are behaving differently from those we have seen elsewhere," says Hay. "It is early days in terms of what we know about the viruses causing these infections."

Researchers are sequencing more strains from the Turkey cases, to see whether they share the mutations and to check for further changes. Samples were expected to arrive in London on 18 January, after being held up for more than a week in Turkey because of the Eid ul-Adha holiday period.
 

pixmo

Bucktoothed feline member
<table width="100%" border="1" cellspacing="0" cellpadding="3" bordercolor="#000000" height="43"><tr><td bgcolor="D08153"><font face="Verdana, Arial, Helvetica, sans-serif" size="4"><b><font size="4" color="#FFFFFF">World Powers Offer $1.9B to Fight Bird Flu </font></b></font></td></tr><tr><td bgcolor="#f5f5dc" height="2"><div align="left"><font face="Verdana, Arial, Helvetica, sans-serif" size="4"><b><font size="2">
http://www.forbes.com/technology/feeds/ap/2006/01/18/ap2459259.html</B>

After a year of unprecedented appeals for money to cope with the Asian tsunami and the South Asia earthquake, the world dug deeper Wednesday, pledging $1.9 billion to fight bird flu and prepare for a potential pandemic.

The United States alone came up with $334 million that will largely be used to help poor countries in Southeast Asia, such as Vietnam and Indonesia, where the H5N1 bird flu virus is endemic. The European Union pledged another $261 million, responding with a renewed sense of urgency after the disease killed four children in Turkey.

As the two-day donors conference wrapped up in Beijing, participants were again reminded of the risk as China reported its sixth human death.

"Nobody's wishing for more tragedies or more crises, but if the world has a better ability to respond to those, I think that's a good thing," said Jim Adams, head of the World Bank's bird flu task force, who said the $1.9 billion in pledges over three years was a proactive step for the international aid community, which often responds to major disasters after they happen.

The World Bank had estimated $1.2 billion to $1.5 billion would be needed to prepare for a potential global pandemic and to fight bird flu, which has killed or forced the slaughter of an estimated 140 million domestic birds since it began ravaging poultry stocks across Asia in late 2003. The virus has also jumped from poultry to people, killing at least 79 people in east Asia and Turkey.

Experts worry the virus could mutate into a form easily spread from person to person, possibly sparking a global pandemic that kills millions. So far, human cases have been traced to contact with sick birds.

David Nabarro, the U.N. coordinator on avian and human influenza, said the international outpouring of support at the conference attended by more than 100 countries showed a determination to try to avert disaster.

"What we've seen today is that the world really does care and wants to respond effectively to the threat of avian influenza and a possible human pandemic," he said, describing the response as "quite extraordinary."

About $1 billion of the money came in the form of grants, while the other $900 million will be distributed as loans - including $500 million from the World Bank.

The U.S. pledge, the most of any single country, was mostly in the form of grants and technical assistance. Billions more will be spent over the next three years to develop vaccines and additional funding will come later for the regional stockpiling of antiviral drugs, said Nancy Powell, U.S. senior coordinator for avian influenza and infectious diseases.

About $280 million was newly approved by Congress, while the remainder was moved from existing programs, including $31.3 million originally set aside for the tsunami. Powell said most of the U.S. funding would be focused on the hardest-hit countries in Southeast Asia.

"It certainly puts a responsibly, that we've taken very seriously, to be among the leaders in the effort," she said. "It will be used in coordination with the other donors and with the technical agencies."

Large chunks of the total $1.9 billion will go to poor countries where the H5N1 virus poses the greatest threat, including improving surveillance, rapid response and containment mechanisms should a pandemic flu strain emerge within their borders.

Other money will be used for strengthening laboratories and poultry vaccination programs. The World Health Organization, U.N. Food and Agriculture Organization and the World Organization for Animal Health will also receive funding.

EU Health Commissioner Markos Kyprianou said the EU increased its commitment to $121 million, about $20 million more than it announced last week. In addition, he said the 25 member states pledged a combined $140 million.

"Never before has humankind had a window of opportunity to prepare for the event of a pandemic before it actually happens," he said.

Meanwhile, Japan pledged $159 million and host China pitched in $10 million as Premier Wen Jiabao promised the communist government would be forthcoming with information about outbreaks.

"China is ready to fully use the existing cooperation mechanisms to give countries and international organizations concerned, timely and accurate updates on the latest developments of the avian influenza epidemics," he told donors.

China was criticized for its sluggish response to severe acute respiratory syndrome, or SARS, in 2003.

The conference drew more than 700 delegates and was hosted by China, the World Bank and the European Commission.
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JPD

Inactive
California unveils flu plan

http://www.dailynews.com/ci_3414545

By Harrison Sheppard, Sacramento Bureau

SACRAMENTO -- California would take steps as drastic as shutting schools, limiting public events and asking people to wear masks in public in order to cope with a possible bird flu pandemic, under a draft plan released today by state health officials.

The avian influenza has yet to reach California and is not easily spread among humans, but health officials are worried the virus could mutate, launching a worldwide pandemic on a scale not seen since Spanish flu killed 20 million people in 1918.

"Depending on its severity, an influenza pandemic could cause widespread economic and societal disruption and severely strain our health-care system," said California Department of Health Services director Sandra Shewry.

"In California alone, scientists estimate a pandemic could cause approximately 35 percent of the population to become ill. An influenza pandemic could be the greatest public-health challenge of our times, disrupting all aspects of society and our health-care system."

A normal flu season might result in 35,000 to 40,000 deaths nationwide, while a pandemic could kill that many people in California alone, health officials said.

To prepare for the possibility, California health officials have drafted a plan that spells out strategies designed to contain the virus, distribute treatments and vaccines, and teach people to prepare their own homes and daily activities.

They have also requested additional funds this year and next to implement those strategies and stockpile up to 270,000 doses of antiviral medications.

There is no vaccine yet available to prevent infection of this particular strain of avian flu, health officials said. Pharmaceutical companies are studying the issue, but it is difficult to create a vaccine in anticipation of a mutated strain that does not yet exist.

The federal government has recently announced a plan to prepare to distribute up to 300 million units of vaccine, when created, within four to six months

of an outbreak, and the new state plan outlines strategies to distribute the vaccine to Californians.

In the event of a possible pandemic, state officials will activate a series of emergency procedures, including working with local health officials to increase capacity and staffing at healthcare facilities; quickly identifying and quarantining potential cases; and communicating with the public.

They may also invoke certain "social-distancing" measures that involve limiting mass gatherings where the virus could spread quickly including schools, concerts and sporting events.

State officials would also establish a Disaster Policy Council with top emergency and health officials to make high-level policy decisions.

Some elements of the plan will be implemented prior to a pandemic, such as reinforcing to the public messages about good health practices, like covering one's mouth when sneezing, washing hands, and stockpiling supplies such as bottled water, canned food, batteries and flashlights for an extended emergency.

The California Department of Health Services draft "Pandemic Influenza Preparedness and Response Plan" can be found at www.dhs.ca.gov.

Comments can be submitted by e-mail to panflu@dhs.ca.gov or through the "Making Comments" link on the site through Feb. 15.

A final version of the plan is expected to be ready by this spring.
 

New Freedom

Veteran Member
World Powers Offer $1.9B to Fight Bird Flu

Sheesh......TPTB think money will solve everything!!!! They just might be wrong this time.......!!!
 
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