The Flying Dutchman
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<B><center>Professors sound-off on bird flu
<font size=+1 color=red>Possible pandemic has scientists, health officials, politicians scrambling for a plan</font>
By: Melissa Patterson
Issue date: 11/28/05 Section: News
<A href="http://media.www.ucfnews.com/media/paper174/news/2005/11/28/News/Professors.SoundOff.On.Bird.Flu-1113965.shtml?sourcedomain=www.ucfnews.com&MIIHost=media.collegepublisher.com">Central Florida Future</A></center>
Though it has recently received more attention, the bird flu isn't new. There are more than a dozen strains of avian influenza that frequently sicken birds around the globe. They do not, however, frequently spread to humans and kill them within days.</b>
The current threat is known as H5N1, a highly contagious and rapidly fatal strain of the bird flu. Once contracted, rapid deterioration of the lungs is common, with pneumonia and multi-organ failure usually following. The World Health Organization attributes nearly 70 deaths to H5N1, and, based on the current mortality rate, almost half of everyone infected will die.
In the case of a pandemic, WHO gives a conservative estimate of 7.4 million deaths, but it warns the toll could be much higher. Many wonder: if the avian flu has always been such a common bird illness, why are people suddenly becoming infected?
The avian flu is an RNA virus, much like AIDS, which means it is prone to frequent and rapid mutations, according to Debopam Chakrabarti, assistant professor of molecular and microbiology at UCF. After innumerable useless copies, the virus randomly replicated itself into a version humans are susceptible to.
This is the version that has infected about 130 people, according to WHO - but it's not the one scientists are dreading.
Now that H5N1 has mutated into a form humans are susceptible to, the next step toward a pandemic would be the last step: to have a person already infected with the human flu also contract the bird flu. In a process known as "reassortment," the two viruses would recombine inside the victim's body, producing a deadly hybrid.
This highly fatal hybrid virus, easily passed between humans, would be the harbinger of chaos so many fear. Governments around the globe, including the U.S., have already begun manufacturing vaccines against the current bird flu strain, but some say it's too little, too late.
"I don't think world leaders are doing enough," Annette Khaled, assistant professor of the Biomolecular Science Center at UCF, said. "It takes time for these things to develop, and you have to invest in research. You can't just do things quickly."
President George W. Bush outlined a $7.1 billion strategy Nov. 1 to prepare for the danger of a pandemic, hoping to stockpile enough vaccine to protect 20 million Americans against the current strain of bird flu. But because of the high frequency of mutation, many scientists call this a futile venture and a waste of money.
"Viral vaccinations generally work well as long as the parent virus strain has not mutated," Alexander Cole, assistant professor of molecular and microbiology at UCF, said. However, "Once the virus mutates to the point that the protective antibodies can no longer recognize the virus, the vaccine is no longer effective."
But it's not all bad news. Antiviral drugs like Tamiflu and Relenza are being used as damage control in humans infected with the virus, and in many cases have proved effective. They wouldn't treat the pandemic form of the virus, scientists warn, but they could prove useful in preventing the "reassortment" process that would lead to the pandemic.
Nations and private buyers are rushing to stockpile Tamiflu, seen as the superior antiviral by many, but there is simply not enough to go around. Tamiflu's exclusive manufacturer is already battling a backlog of orders due to the drug's lengthy manufacturing process. At present capacity, it would take 10 years to produce enough for 20 percent of the world's population. Also, is should be emphasized that there is currently no form of the avian flu that is easily transmissible from human to human.
Meanwhile, two of the countries hardest hit by the bird flu, China and Vietnam, took extreme measures to fight the disease on Nov. 15. China promised to vaccinate its entire poultry stock of 14 billion birds, paying all fees involved. Vietnamese officials ordered farmers in its two largest cities to kill or sell all poultry by today.
That may take care of poultry's threat, but it doesn't protect against wild waterfowl, where H5N1 is thought to have originated. WHO believes the spring 2005 die-off of 6,000 migratory birds in Central China may be a signal that the virus is becoming more deadly.
Chakrabarti fears that birds may not be the only threat. There is a possibility that other animals, not just birds, are already silent carriers of the avian influenza, he said.
"I think this virus is showing a little broader host range than the earlier forms," Chakrabarti said. "Some of the disease could be asymptomatic; maybe other animals are getting it [and not showing symptoms]. Then they could pass it through their fecal matter and spread it all over."
There have been several publicized cases of avian flu-related death that could support Chakrabarti's theory. The most recent one involved two Indonesian women this month who died after having no known contact with flu-infected birds, according to a doctor who treated one of the patients.
WHO still maintains that, "though rare, instances of limited human-to-human transmission of H5N1 … have occurred in association with outbreaks in poultry and should not be a cause for alarm. In no instance has the virus spread beyond a first generation of close contacts or caused illness in the general community."
At a Nov. 7-9 meeting in Geneva at WHO headquarters, more than 600 delegates from over 100 countries laid the foundation for worldwide cooperation against the virus. In his conclusion, WHO director-general Lee Jong-wook said, "We have plans on paper, but we must now test them. Once a pandemic virus appears, it will be too late."
Many of those plans include faster and less-expensive vaccine methods. Bush's administration plan, for example, stresses the cell culture method: growing the virus in easy-to-handle cell cultures instead of the current, cumbersome process requiring millions of chicken eggs.
Cell culture vaccines aren't the only contender, as scientists from around the world announce new methods each week. Russia announced Nov. 15, in collaboration with Vietnam, that it could release a new vaccine involving mutations of the virus's cloned DNA by February.
Whatever the method, many scientists agree that it's important to keep researching new possibilities, since chicken eggs might become scarce if many countries are forced to slaughter their poultry populations.
"As the current methods of generating vaccines are laborious, and output is not sufficient for global immunization, it would be prudent to continue our search for alternative vaccine sources and methodologies," Cole said.
Other scientists, including Khaled, are stressing funding for a broader range of research.
"We need to invest a lot more in basic science research," Khaled said. "A lot of research dollars are going into specific diseases … and not enough money is being spent on the basic workings of the human body." She added that this won't immediately yield a cure, "but it will give us more information about how our immune system works."
<B><center>Professors sound-off on bird flu
<font size=+1 color=red>Possible pandemic has scientists, health officials, politicians scrambling for a plan</font>
By: Melissa Patterson
Issue date: 11/28/05 Section: News
<A href="http://media.www.ucfnews.com/media/paper174/news/2005/11/28/News/Professors.SoundOff.On.Bird.Flu-1113965.shtml?sourcedomain=www.ucfnews.com&MIIHost=media.collegepublisher.com">Central Florida Future</A></center>
Though it has recently received more attention, the bird flu isn't new. There are more than a dozen strains of avian influenza that frequently sicken birds around the globe. They do not, however, frequently spread to humans and kill them within days.</b>
The current threat is known as H5N1, a highly contagious and rapidly fatal strain of the bird flu. Once contracted, rapid deterioration of the lungs is common, with pneumonia and multi-organ failure usually following. The World Health Organization attributes nearly 70 deaths to H5N1, and, based on the current mortality rate, almost half of everyone infected will die.
In the case of a pandemic, WHO gives a conservative estimate of 7.4 million deaths, but it warns the toll could be much higher. Many wonder: if the avian flu has always been such a common bird illness, why are people suddenly becoming infected?
The avian flu is an RNA virus, much like AIDS, which means it is prone to frequent and rapid mutations, according to Debopam Chakrabarti, assistant professor of molecular and microbiology at UCF. After innumerable useless copies, the virus randomly replicated itself into a version humans are susceptible to.
This is the version that has infected about 130 people, according to WHO - but it's not the one scientists are dreading.
Now that H5N1 has mutated into a form humans are susceptible to, the next step toward a pandemic would be the last step: to have a person already infected with the human flu also contract the bird flu. In a process known as "reassortment," the two viruses would recombine inside the victim's body, producing a deadly hybrid.
This highly fatal hybrid virus, easily passed between humans, would be the harbinger of chaos so many fear. Governments around the globe, including the U.S., have already begun manufacturing vaccines against the current bird flu strain, but some say it's too little, too late.
"I don't think world leaders are doing enough," Annette Khaled, assistant professor of the Biomolecular Science Center at UCF, said. "It takes time for these things to develop, and you have to invest in research. You can't just do things quickly."
President George W. Bush outlined a $7.1 billion strategy Nov. 1 to prepare for the danger of a pandemic, hoping to stockpile enough vaccine to protect 20 million Americans against the current strain of bird flu. But because of the high frequency of mutation, many scientists call this a futile venture and a waste of money.
"Viral vaccinations generally work well as long as the parent virus strain has not mutated," Alexander Cole, assistant professor of molecular and microbiology at UCF, said. However, "Once the virus mutates to the point that the protective antibodies can no longer recognize the virus, the vaccine is no longer effective."
But it's not all bad news. Antiviral drugs like Tamiflu and Relenza are being used as damage control in humans infected with the virus, and in many cases have proved effective. They wouldn't treat the pandemic form of the virus, scientists warn, but they could prove useful in preventing the "reassortment" process that would lead to the pandemic.
Nations and private buyers are rushing to stockpile Tamiflu, seen as the superior antiviral by many, but there is simply not enough to go around. Tamiflu's exclusive manufacturer is already battling a backlog of orders due to the drug's lengthy manufacturing process. At present capacity, it would take 10 years to produce enough for 20 percent of the world's population. Also, is should be emphasized that there is currently no form of the avian flu that is easily transmissible from human to human.
Meanwhile, two of the countries hardest hit by the bird flu, China and Vietnam, took extreme measures to fight the disease on Nov. 15. China promised to vaccinate its entire poultry stock of 14 billion birds, paying all fees involved. Vietnamese officials ordered farmers in its two largest cities to kill or sell all poultry by today.
That may take care of poultry's threat, but it doesn't protect against wild waterfowl, where H5N1 is thought to have originated. WHO believes the spring 2005 die-off of 6,000 migratory birds in Central China may be a signal that the virus is becoming more deadly.
Chakrabarti fears that birds may not be the only threat. There is a possibility that other animals, not just birds, are already silent carriers of the avian influenza, he said.
"I think this virus is showing a little broader host range than the earlier forms," Chakrabarti said. "Some of the disease could be asymptomatic; maybe other animals are getting it [and not showing symptoms]. Then they could pass it through their fecal matter and spread it all over."
There have been several publicized cases of avian flu-related death that could support Chakrabarti's theory. The most recent one involved two Indonesian women this month who died after having no known contact with flu-infected birds, according to a doctor who treated one of the patients.
WHO still maintains that, "though rare, instances of limited human-to-human transmission of H5N1 … have occurred in association with outbreaks in poultry and should not be a cause for alarm. In no instance has the virus spread beyond a first generation of close contacts or caused illness in the general community."
At a Nov. 7-9 meeting in Geneva at WHO headquarters, more than 600 delegates from over 100 countries laid the foundation for worldwide cooperation against the virus. In his conclusion, WHO director-general Lee Jong-wook said, "We have plans on paper, but we must now test them. Once a pandemic virus appears, it will be too late."
Many of those plans include faster and less-expensive vaccine methods. Bush's administration plan, for example, stresses the cell culture method: growing the virus in easy-to-handle cell cultures instead of the current, cumbersome process requiring millions of chicken eggs.
Cell culture vaccines aren't the only contender, as scientists from around the world announce new methods each week. Russia announced Nov. 15, in collaboration with Vietnam, that it could release a new vaccine involving mutations of the virus's cloned DNA by February.
Whatever the method, many scientists agree that it's important to keep researching new possibilities, since chicken eggs might become scarce if many countries are forced to slaughter their poultry populations.
"As the current methods of generating vaccines are laborious, and output is not sufficient for global immunization, it would be prudent to continue our search for alternative vaccine sources and methodologies," Cole said.
Other scientists, including Khaled, are stressing funding for a broader range of research.
"We need to invest a lot more in basic science research," Khaled said. "A lot of research dollars are going into specific diseases … and not enough money is being spent on the basic workings of the human body." She added that this won't immediately yield a cure, "but it will give us more information about how our immune system works."




